Claims
- 1. A method of initiating formation of a hydrogel in situ comprising the steps:
delivering a solid article comprising an initiator to the intended site of formation of the hydrogel; and delivering a gellable composition that will form a hydrogel in response to the initiator to the intended site of formation of the hydrogel; whereby the gellable composition forms the hydrogel.
- 2. The method of claim 1, wherein the solid article comprises microspheres.
- 3. The method of claim 1, wherein the solid article comprises a solid embolic device.
- 4. The method of claim 1, wherein the solid article is delivered to the site of intended formation of the hydrogel before the gellable composition is delivered to the site.
- 5. The method of claim 1, wherein the solid article is the tip of a catheter.
- 6. A method of initiating formation of a hydrogel comprising the steps:
delivering a gellable composition that can form a hydrogel in response to an initiator to the intended site of formation of the hydrogel; and infusing a solution of the initiator to the intended site of formation of the hydrogel.
- 7. The method of claim 6, wherein the initiator solution is infused via a separate access point from the gellable composition.
- 8. The method of claim 6, wherein the initiator solution is infused via a coaxial or side by side multi-lumen catheter, wherein the lumen infusing the initiator solution is shorter than the lumen delivering the gellable composition.
- 9. A method of initiating formation of a hydrogel comprising the steps:
delivering a gellable composition that can form a hydrogel in response to an initiator to the intended site of formation of the hydrogel via a catheter; and providing an initiator within the catheter so that when the gellable composition passes by the initiator, formation of the hydrogel is initiated.
- 10. The method of claim 1, wherein the gellable composition comprises macromers having crosslinkable groups that are crosslinkable via free radical polymerization.
- 11. The method of claim 10, wherein the crosslinkable groups are olefinically unsaturated groups.
- 12. The method of claim 10, wherein the free radical polymerization is redox initiated.
- 13. The method of claim 12, wherein the redox initiation is performed via an oxidant and a reductant and one of the oxidant or reductant is the initiator.
- 14. The method of claim 6, wherein the gellable composition comprises macromers having crosslinkable groups that are crosslinkable via free radical polymerization.
- 15. The method of claim 14, wherein the crosslinkable groups are olefinically unsaturated groups.
- 16. The method of claim 14, wherein the free radical polymerization is redox initiated.
- 17. The method of claim 16, wherein the redox initiation is performed via an oxidant and a reductant and one of the oxidant or reductant is the initiator.
PRIORITY CLAIM
[0001] This application claims priority to U.S. provisional application Serial No. 60/332,448 filed on Nov. 16, 2001.
Provisional Applications (1)
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Number |
Date |
Country |
|
60332448 |
Nov 2001 |
US |