Claims
- 1. An array of clones, comprising multiple groups of vessels, of which at least two of said vessels each contain a clone, wherein each clone (i) contains an exogenous segment within a gene of its genome, such that said gene is disrupted, and (ii) is arranged in said array in predetermined fashion.
FIELD OF THE INVENTION
[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 10/097,431 filed Mar. 15, 2002, which is a continuation-in-part of U.S. patent application Ser. No. 10/028,970, filed Dec. 28, 2001, which claims the benefit of U.S. provisional patent application Serial No. 60/258,388, filed Dec. 28, 2000. This patent application also claims the benefit of U.S. provisional patent application 60/383,782 filed May 30, 2002. All of these priority applications are herein incorporated by reference. The present invention relates to novel cellular arrays, nucleotide trapping constructs and homologous recombination vectors that may be used to generate polynucleotide libraries, polynucleotide arrays and cell libraries, all of which can be useful in the context of high-throughput, functional-genomics analysis to decipher gene functions and to identify targets with therapeutic and/or diagnostic potential. The present invention relates to novel cellular arrays, nucleotide trapping constructs and homologous recombination vectors that may be used to generate polynucleotide libraries, polynucleotide arrays and cell libraries, all of which can be useful in the context of high-throughput, functional-genomics analysis to decipher gene functions and to identify targets with therapeutic and/or diagnostic potential.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60258388 |
Dec 2000 |
US |
|
60383782 |
May 2002 |
US |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
10097431 |
Mar 2002 |
US |
Child |
10172715 |
Jun 2002 |
US |
Parent |
10028970 |
Dec 2001 |
US |
Child |
10097431 |
Mar 2002 |
US |