Claims
- 1. A process for preparing a compound of formula IV: comprising:(1) acylating a compound of formula I wherein R1 and R2 are each independently any suitable organic group; to provide a corresponding compound of formula II (2) alcoholyzing the compound of formula II to provide a corresponding compound of formula III.; and (3) oxidizing the compound of formula III to provide the compound of formula IV.
- 2. The process of claim 1 wherein the oxidizing comprises a transition metal oxidant, oxygen, ozone, a peroxide, or a combination thereof.
- 3. The process of claim 2 wherein the transition metal oxidant is a chromium (IV) oxidant, potassium permanganate, sodium manganate, manganese (IV) dioxide, ruthenium tetroxide, or a combination thereof.
- 4. The process of claim 3 wherein the chromium (IV) oxidant is dipyridine Cr(IV) oxide, pyridinium chlorochromate, pyridinium dichromate, or a combination thereof.
- 5. The process of claim 1 wherein the oxidizing comprises palladium chloride or potassium carbonate.
- 6. The process of claim 1 wherein the oxidizing comprises dimethyl sulfoxide and an electrophilic molecule.
- 7. The process of claim 6 wherein the electrophilic molecule is diclohexylcarbodiimide, acetic anhydride, trifluoroacetic anhydride, oxalyl chloride, sulfur trioxide, or a combination thereof.
- 8. The process of claim 6 wherein the electrophilic molecule is an acid anhydride, an acid chloride, or a combination thereof.
- 9. The process of claim 1 wherein the oxidizing comprises dimethyl sulfoxide and N-chlorosuccinimide; or dimethyl sulfoxide and chlorine.
- 10. The process of claim 1 wherein the oxidizing comprises aluminum alkoxide and a compound having a carbonyl group.
- 11. The process of claim 8 wherein the compound having the carbonyl group is quinone or fluorenone.
- 12. The process of claim 1 wherein R1 and R2 are each independently (C1-C10)alkyl, (C2-C10)alkenyl, (C2-C10)alkynyl, (C6-C10)aryl, (C1-C10)alkoxy or (C6-C10)aryl(C1-C10)alkyl, wherein any alkyl, alkoxy, alkenyl, alkynyl, aryl or arylalkyl of R1 and R2 can be optionally substituted with one or more halo, nitro, cyano, trifluoromethyl, hydroxy, SR or NRR, wherein each R is independently H or (C1-C10)alkyl.
- 13. The process of claim 1 wherein R1 and R2 can each independently (C1-C10)alkyl, (C2-C10)alkenyl, (C2-C10)alkynyl, or (C6-C10)aryl.
- 14. The process of claim 1 wherein R1 and R2 are each independently (C1-C10)alkyl.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a divisional of application Ser. No. 09/840,627 Apr. 23, 2001. This application is a continuation-in-part application of U.S. application Ser. No. 09/480,406 now U.S. Pat. No. 6,232,481; filed on Jan. 11, 2000.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5804575 |
Pezzuto et al. |
Sep 1998 |
A |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/480406 |
Jan 2000 |
US |
Child |
09/840627 |
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US |