Claims
- 1. A method for reducing chronic stress in a mammal by downregulating the activity of the HPA axis by administering to said mammal an effective amount of a sensory regimen.
- 2. A method according to claim 1, wherein the sensory regimen includes the administration of a CRH antagonist or an antidepressant.
- 3. A method according to claim 1, wherein the activity of the HPA axis is downregulated by reducing the amount of total daily adrenocortical hormone in said mammal.
- 4. The method of claim 3, wherein the total daily adrenocortical hormone is cortisol.
- 5. The method of claim 4, wherein cortisol is reduced by at least about 5 to about 50%, based on the total daily cortisol present, in said mammal at the start of said regimen.
- 6. The method of claim 4, wherein cortisol is reduced by at least about 10 to about 40%, based on the total daily cortisol present in said mammal at the start of said regimen.
- 7. The method of claim 4, wherein cortisol is reduced by at least about 15 to about 30%, based on the total daily cortisol present in said mammal at the start of said regimen.
- 8. The method of claim 3, wherein the reduction occurs within a period of about 1 to about 14 days from the start of the regimen.
- 9. The method of claim 8, wherein the reduction is maintained for a period of 1 day to 2 years.
- 10. A method of improving the quality of life of an individual comprising reducing chronic stress according to the method of claim 1.
- 11. A method according to claim 1, wherein the activity of the HPA axis is downregulated by reducing adrenocortical hormone in said mammal at any time point in the period from about 4 to about 8 hours following morning waking.
- 12. A method according to claim 11, wherein the adrenocortical hormone is cortisol.
- 13. The method of claim 12, wherein cortisol is reduced by about, 5 to about 60%, based on the amount of cortisol present in said mammal at the start of said regimen.
- 14. The method of claim 12. wherein cortisol is reduced by about 10 to about 60%, based on the amount of cortisol present in said mammal at the start of said regimen.
- 15. The method of claim 12, wherein cortisol is reduced by about 20 to about 50%, based on the amount of cortisol present in said mammal at the start of said regimen.
- 16. The method of claim 11, wherein the reduction occurs within a period of 1 to 14 days from the start of the regimen
- 17. The method of claim 16, wherein the reduction is maintained for a period of 1 day to 2 years.
- 18. A method according to claim 1, wherein the activity of the HPA axis is downregulated by reducing the total daily adrenocortical hormone minus the integrative measure of morning peak adrenocortical hormone in said mammal.
- 19. The method of claim 18, wherein the adrenocortical hormone is cortisol.
- 20. The method of claim 19, wherein cortisol is reduced by about 5 to about 70%, based on the amount of cortisol present in said mammal at the start of said regimen.
- 21. The method of claim 19, wherein cortisol is reduced by about 10 to about 60%, eased on the amount of cortisol present in said mammal at the start of said regimen.
- 22. She method of claim 19, wherein cortisol is reduced by about 20 to about 50%, based on the amount of cortisol present in said mammal at the start of said regimen.
- 23. The method of claim 18, wherein the reduction occurs within a period of 1 to 14days from the start of the regimen.
- 24. The method of claim 23, wherein the reduction is maintained for a period of f day to 2 years.
CLAIM OF PRIORITY
[0001] This application claims priority to U.S. patent application Ser. No. 60/256,813, filed Dec. 20, 2000, the disclosure of which is hereby incorporated by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60256813 |
Dec 2000 |
US |