Bossard, M.J. et al., 1996, "Proteolytic Activity of Human Osteoclast Cathepsin K", J of Biol Chemistry 271:12517-12524. |
Bromme, D. et al., 1996, "Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts", J of Biol Chemistry 271:2126-2132. |
Drake, F. et al., 1996, "Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts", J of Biol Chemistry 271:12511-12516. |
Gelb, B. et al., 1996, "Pycnodysostosis: Refined Linkage and Radiation Hybrid Analyses Reduce the Critical Region to 2 cM at 1q21 and Map Two Candidate Genes", Human Genet. 98:141-144. |
Riese, R. et al., 1996, "Essential Role for Cathepsin S in MHC Class II-Associated Invariant Chain Processing and Peptide Loading", Immunity 4:357-366. |
Bromme, and Okamoto, 1995, "Human Cathepsin O2, a Novel Cysteine Protease Highly Expressed in Osteoclastomas and Ovary Molecular Cloning, Sequencing and Tissue Distribution", Biol Chem Hoppe-Seyler 376:379-386. |
Debari, K. et al., 1995, "An Ultrastructural Evaluation of the Effects of Cysteine-Proteinase Inhibitors on Osteoclastic Resorptive Funtions", Calcif. Tissue Int. 56:566-570. |
Gelb, B.D. et al., 1995, "Linkage of Pycnodysostosis to Chromosome 1q21 by Homozygosity Mapping", Nature Genet. 10:235-237. |
Horinouchi, K. et al., 1995, "Acid Sphingomyelinase Deficient Mice: A Model of Types A and B Niemann-Pick Disease", Nature Genetics 10:288-293. |
Inaoka, T. et al., 1995, "Molecular Cloning of Human cDNA for Cathepsin K: Novel Cysteine Proteinase Predominantly Expressed in Bone", Biochem. Biophys. Res. Commun. 206:89-96. |
Li, Y. et al., 1995, "Cloning and Complete Coding Sequence of a Novel Human Cathepsin Expressed in Giant Cells of Osteoclastomas", J. Bone Miner. Res. 10:1197-1202. |
Munger, J. et al., 1985, "Lysosomal Processing of Amyloid Precursor Protein to A.beta. Peptides: A Distinct Role for Cathepsin S", Biochem. J. 311:299-305. |
Otterbach, and Stoffel, 1995, "Acid Sphingomyelinase-Deficient Mice Mimic the Neurovisceral Form of Human Lysosomal Storage Disease (Niemann-Pick Disease)", Cell 81:1053-1061. |
Palmer, J. et al., 1995, "Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors", J. Med. Chem. 38:3193-3196. |
Polymeropoulos, M. et al., 1995, "The Gene for Pycnodysostosis Maps to Human Chromosome 1 cen-q21", Nature Genet. 10:238-239. |
Richard, I. et al., 1995, "Mutations in the Proteolytic Enzyme Calpain 3 Cause Limb-Girdle Muscular Dystrophy Type 2A", Cell 81:27-40. |
Rousseau, F., 1995, "Stop Codon FGFR3 Mutations in Thanatophoric Dwarfism Type 1", Nature Genetics 10:11-12. |
Shi, G. et al., 1995, "Molecular Cloning of Human Cathepsin O, a Novel Endoproteinase and Homologue of Rabbit OC2", FEBS Letters 357:129-134. |
Sim, and Doorn, 1995, "Radiographic Measurement of Bone Mineral: Reviewing Dual Energy X-Ray Absorptiometry", Austral. Phys. Eng. Sci. Med. 18:65-80. |
Sohrabji, F. et al., 1995, "Identification of a Putative Estrogen Response Element in the Gene Encoding Brain-Derived Neurotrophic Factor", PNAS U.S.A. 92:11110-11114. |
Goto, T., 1994, "Localization of Cathepsins B, D, and L in the Rat Osteoclast by Immuno-Light and -Electron Microscopy", Histochemistry 101:33-40. |
Kirschke, H. and Wiederanders, B., 1994, "Cathepsin S and Related Lysosomal Endopeptidases", Methods in Enzymology: 244:500, Academic Press, NY. |
Krane and Simon, 1994, in Scientific American Medicine, Rubenstein, E. & Felderman, D.D., ed., Scientific American, Inc., New York, pp. 1-26. |
Li, Y.P. et al., 1994, "Cloning and Characterization of a Novel Cathepsin from Human Osteoclasts" (Abstract), Mol. Biol. Cell 5:335a. |
Shi, G. et al., 1994, "Human Cathepsin S: Chromosomal Localization, Gene Structure, and Tissue Distribution", J. Biol. Chem. 269:11530-11536. |
Tezuka, K. et al., 1994, "Molecular Cloning of a Possible Cysteine Proteinase Predominantly Expressed in Osteoclasts", J. Biol. Chem. 269:1106-1109. |
Velasco, G. et al., 1994, "Human Cathepsin O", J. Biol. Chem. 269:27136-27142. |
Wagner, R., 1994, "Gene Inhibition Using Antisense Oligonucleotides", Nature 372:333-335. |
Blair, H. et al., 1993, "Recent Advances Toward Understanding Osteoclast Physiology", Clin. Orthop. 294:7-22. |
Cauley, J. et al., 1993, "Effects of Thiazide Diuretic Therapy on Bone Mass, Fractures, and Falls", Ann. Intern. Med. 118:666-673. |
Chauhan, S. et al., 1993, "Cloning, Genomic Organization, and Chromosomal Localization of Human Cathepsin L", J. Biol. Chem. 268:1039-1045. |
Dietz, H. et al., 1993, "The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations", Science 259:680-682. |
Gong, Q. et al., 1993, "Characterization of the Cathepsin B Gene and Multiple mRNAs in Human Tissues: Evidence for Alternative Splicing of Cathepsin B Pre-mRNA", DNA and Cell Biol. 12:299-309. |
Horowitz, M., 1993, "Cytokines and Estrogen in Bone: Anti-Osteoporotic Effects", Science 260:626-627. |
Kakegawa, H. et al., 1993, "Participation of Cathepsin L on Bone Resorption", FEBS 321:247-250. |
Wood, S. et al., 1993, "Simple and Efficient Production of Embryonic Stem Cell-Embryo Chimeras by Coculture", PNAS USA 90:4582-4584. |
Bradley, A. et al., 1992, "Modifying the Mouse: Design and Desire", Bio/Technology 10:534-539. |
Chapuy, M. et al., 1992, "Vitamin D.sub.3 and Calcium to Prevent Hip Fractures in Elderly Women", N. Engl. J. Med. 327:1637-1642. |
Christiansen, C., 1992, "Prevention and Treatment of Osteoporosis: A Review of Current Modalities" Bone 13 (Supp.1):S35-S39. |
Everts, V. et al., 1992, "Degradation of Collagen in the Bone-Resorbing Compartment Underlying the Osteoclast Involves Both Cysteine-Proteinases and Matrix Metalloproteinasses", J. Cell. Physiol. 150:221-231. |
Helene, C. et al., 1992, "Control of Gene Expression by Triple Helix-Forming Oligonucleotides", Ann. NY Acad. Sci. 660:27-36. |
Maher, L.J., 1992, "DNA Triple-Helix Formation: An Approach to Artificial Gene Repressors?", Bioassays 14:807-815. |
Page A. et al., 1992, "Human Osteoclastomas Contain Multiple Forms of Cathepsin B", Biochem Biophys. Acta 1116:57-66. |
Riggs, B. et al., 1992, "The Prevention and Treatment of Osteoporosis", N. Engl. J. Med. 327:620-627. |
Rodan, G., 1992, "Introduction to Bone Biology", Bone 13:S3-S6. |
Shi, G. et al., 1992, "Molecular Cloning and Expression of Human Alveolar Macrophage Cathepsin S, an Elastinolytic Cysteine Protease", J. Biol. Chem. 267:7258-7262. |
Greenspan, A., 1991, "Sclerosing Bone Dysplasias--a Target-Site Approach", Skeletal Radiol. 20:561-583. |
Helene, C., 1991, "The Anti-Gene Strategy: Control of Gene Expression by Triplex-Forming-Oligonucleotides", Anti-Cancer Drug Design 6:569-584. |
Kim, H. et al., 1991, "Problems Encountered in Detecting a Targeted Gene by the Polymerase Chain Reaction", Gene 103:227-233. |
Prince, R. et al., 1991, "Prevention of Postmenopausal Osteoporosis", N. Engl. J. Med. 325:1189-1195. |
Avioli, L. et al., 1990, in Metabolic Bone Disease and Clinical Related Disorders, Avioli, L.V. and Crane eds., Saunders Co. Philadelphia, p. 397. |
Ferrara et al., 1990, "Gene Structure of Mouse Cathepsin B", FEBS Letters 273:195-199. |
Hock, J.M. et al., 1990, "Anabolic Effect of Human Synthetic Parathyroid Hormone-(1-34) Depends on Growth Hormone", Endocrinology 127:1804-1810. |
Sarver, N. et al., 1990, "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents", Science 247:1222-1225. |
Storm, T. et al., 1990, "Effect of Intermittent Cyclical Etidronate Therapy on Bone Mass and Fracture Rate in Women with Postmenopausal Osteoporosis", N. Engl. J. Med. 322:1265-1271. |
Wagner, E., 1990, "On Transferring Genes into Stem Cells and Mice", EMBO J. 9:3025-3032. |
Watts, N. et al., 1990, "Intermittent Cyclical Etidronate Teatment of Postmenopausal Osteoporosis", N. Engl. J. Med. 323:73-79. |
Barribault, H. et al., 1989, "Embryonic Stem Cell Culture and Gene Targeting in Transgenic Mice", Mol. Biol. Med. 6:481-492. |
Capecchi, M., 1989, "Altering the Genome by Homologous Recombination", Science 244:1288-1292. |
Cappecchi, M., 1989, "The New Mouse Genetics: Altering the Genome by Gene Targeting", Trends in Genet. 5:70-76. |
Frohman, M. et al., 1989, "Cut, Paste, and Save: New Approaches to Altering Specific Genes in Mice", Cell 56:145-147. |
Gordon, J., 1989, "Transgenic Animals", Int'l Rev. Cytol. 115:171-229. |
Kirshke, H. et al., 1989, "Cathepsin S from Bovine Spleen", Biochem. J. 264:467-473. |
Lavitrano, M. et al., 1989, "Sperm Cells as Vectors for Introducing Foreign DNA into Eggs: Genetic Transformation of Mice", Cell 57:717-723. |
Letsinger, R. et al., 1989, "Cholesterol-Conjugated Oligonecleotides: Synthesis, Properties and Activity as Inhibitors of Replication of Human Immunodeficiency Virus in Cell Culture", PNAS USA 86:6553-6556. |
Melton, L.J. and Riggs, B.L., 1989, in Clinical Disorders of Bone and Mineral Metabolism, Kleerekoper, M. and Krane, S.M. eds., Mary Ann Liebert, NY, p. 145. |
Sedivy, J. et al., 1989, "Positive Genetic Selection for Gene Disruption in Mammalian Cells by Homologous Recombination", PNAS USA 86:227-231. |
Thompson, S. et al., 1989, "Germ Line Transmission and Expression of a Corrected HPRT Gene Produced by Gene Targeting in Embryonic Stem Cells", Cell 56:313-321. |
Everts, V et al., 1988, "Effects of the Proteinase Inhibitors Leupeptin and E-64 on Osteoclastic Bone Resorption", Calcif. Tissue Int. 43:172-178. |
Haseloff and Gerlach, 1988, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities", Nature 334:585-591. |
Jaenisch, R., 1988, "Transgenic Animals", Science 240:1468-1474. |
Kim, H. et al., 1988, "Recombinant Fragment Assay for Gene Targeting Based on the Polymerase Chain Reaction", Nucl. Acids Res. 16:8887-8903. |
Krol, A. et al., 1988, "Modulation of Eukaryotic Gene Expression by Complementary RNA or DNA Sequences", Biotechniques 6:958-976. |
Mansour, S. et al., 1988, "Disruption of the Proto-Oncogene int-2 in Mouse Embryo-Derived Stem Cells: A General Strategy for Targeting Mutations to Non-Selectable Genes", Nature 336:348-352. |
Sarin, P. et al., 1988, "Inhibition of Acquired Immunodeficiency Syndrome Virus by Oligodeoxynucleoside Methylphosphonates", PNAS USA 85:7448-7451. |
Stein, C.A. et al., 1988, "Physiochemical Properties of Phosphorothioate Oligodeoxynucleotides", Nucl. Acids Res. 16:3209-3221. |
Zon, G., 1988, "Oligonucleotide Analogues as Potential Chemotherapeutic Agents", Pharm. Res. 5:539-549. |
Gautier, G. et al., 1987, ".alpha.-DNA IV: .alpha.-anomeric and .beta.-anomeric Tetrathymidylates Covalently Linked to Intercalating Oxazolopyridocarbazole. Synthesis, Physicochemical Properties and Poly (rA) Binding", Nucl. Acids Res. 15:6625-6641. |
Inoue, H. et al., 1987, "Syntheis and Hybridization Studies on Two Complementary Nona(2'-O-methyl)ribonucleotides", Nucl. Acids Res. 15:6131-6148. |
Inoue, H. et al., 1987, "Sequence-dependent Hydrolysis of RNA Using Modified Oligonucleotide Splints and RNase H", FEBS Letters 215:327-330. |
Kaufman and Murtha, 1987, "Translational Control Mediated by Eucaryotic Initiation Factor-2 Is Restricted to Specific mRNAs in Transfected Cells". Mol. Cell. Biol. 7:1568. |
Kirshke and Barrett, 1987, in Lysozomes: Their Role in Protein Breakdown, Glaumann, H. & Ballard, F.J. eds., Academic Press, London, pp. 193-238. |
Lemaitre, M. et al., 1987, "Specific Antirviral Activity of a Poly (L-lysine)-Conjugated Oligodeoxyribonucleotide Sequence Complementary to Vesicular Stomatitis Virus N Protein mRNA Initiation Site", PNAS 84:648-652. |
Thomas and Capecchi, 1987, "Site-Directed Mutagenesis by Gene Targeting in Mouse Embryo-Derived Stem Cells", Cell 51:503-512. |
Been and Cech, 1986, "One Binding Site Determines Sequence Specificity of Tetrahymena Pre-rRNA Self-Splicing, Trans-Splicing, and RNA Enzyme Activity", Cell 47:207-216. |
Chan, S. et al., 1986, "Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs", PNAS USA 83:7721-7725. |
Gossier A. et al., 1986, "Transgenesis by Means of Blastocyst-Derived Embryonic Stem Cell Lines", PNAS USA 83:9065-9069. |
Riggs and Melton, 1986, "Medical Progess--Involutional Osteoporosis", N. Engl. J. Med. 314:1676. |
Robertson, H.D. et al., 1986, "Clues about RNA Enzymes", Nature 322:445-448. |
Zaug, A. et al., 1986, "The Tetrahymena Ribozyme Acts like and RNA Restriction Endonuclease", Nature 324:429-433. |
Zaug and Cech, 1986, "The Intervening Sequence RNA of Tetrahymena is an Enzyme", Science 231:470-475. |
Everts, V. et al., 1985, "Phagocytosis of Bone Collagen by Osteoclasts in Two Cases of Pycnodysostosis", Calcif. Tissue Int. 37:25-31. |
Small, J. et al., 1985, "Analysis of a Transgenic Mouse Containing Simian Virus 40 and v-myc Sequences", Moll. Cell Biol. 5:642-648. |
Van der Putten, H. et al., 1985, "Efficient Insertion of Genes into the Mouse Germ Line via Retroviral Vectors", PNAS U.S.A. 82:6148-6152. |
Bradley, A. et al., 1984, "Formation of Germ-Line Chimaeras from Embryo-Derived Teratocarcinoma Cell Lines", Nature 309:255-256. |
Delaisse, J. et al., 1984, "In Vivo and In Vitro Evidence for the Involvment of Cysteine Proteinasses in Bone Resorption", Biochem. and Biophys. Res. Commun. 125:441-447. |
Zaug, A. et al., 1984, "A Labile Phosphodiester Bond at the Ligation Jucntion in a Circular Intervening Sequence RNA", Science 224:574-578. |
Lo, C., 1983,"Transformation by Iontophoretic Microinjection of DNA: Multiple Integrations without Tandem Insertions", Mol. and Cell. Biol. 3:1803-1814. |
Nagent de Deuxchaisnes, C., 1983, in Osteoporosis, a Multi-Disciplinary Problem, Royal Society of Medicine Int'l Congress and Symposium Series No.55, Academic Press, London, p. 291. |
Bishop and Desnick, 1981, "Affinity Purification of .alpha.-Galactosidase A from Human Spleen, Placenta, and Plasma with Elimination of Pyrogen Contamination", J. of Biol. Chem. 256:1307-1316. |
Brinster, R. et al., 1982, "Regulation of Metallothionein-Thymidine Kinase Fusion Plasmids Injected into Mouse Eggs", Nature 296:39-42. |
Hunt, D.M. et al., 1982, "Haemoglobin Constant Spring has an Unstable .alpha. Messenger RNA", Brit J. of haematology 51:405-413. |
Benoist and Chambron, 1981, "In Vivo Sequence Requirements of the SV40 Early Promoter Region", Nature 290:304-310. |
Evans, M.J. et al., 1981, "Establishment in Culture of Pluripotential Cells from Mouse Embryos", Nature 292:154-156. |
Liebhaber, S. et al., 1981, "Differentiation of the mRNA Transcripts Originating from the .alpha.1-and .alpha.2-Globin Loci in Normals and .alpha.-Thalassemics", J. Clin Invest 68:439-446. |
Wager, M. et al., 1981, "Nucleotide Sequence of the Thymidine Kinase Gene of Herpes Simplex Virus Type 1", PNAS USA 78:1441-1445. |
Delaisse, J. et al., 1980, "Inhibition of Bone Resorption in Culture by Inhibitors of Thiol Proteinases", Biochem. J. 192:365-368. |
Yamamoto, T. et al., 1980, "Identification of a Functional Promoter in the Long Terminal Repeat of Rous Sarcoma Virus", Cell 22:787-797. |
Clegg, B. et al., 1971, "Haemoglobin Constant Spring-A Chain Termination Mutant?", Nature 234:337-340. |
Andren, L. et al., 1962, "Osteopetrosis Acro-Osteolytica", Acta Chir. Scand.124:496-507. |
Albright, F. et al., 1941, "Postmenopausal Osteoporosis", JAMA 116:2465-2474. |
Chen, C.G. et al., 1996, "Reduction in Gal-.alpha.1,3-Gal Epitope Expression in Transgenic Mice Expressing Human H-Transferase", Xenotransplantation 3:69-75. |
Koike, C. et al., 1996, "Introduction of .alpha.(1,2)-fucosyltransferase and its Effect on .alpha.-Gal Epitopes in Transgenic Pig", Xenotransplantation 3:81-86. |
Koike, c. et al., 1996, "Converting .alpha.-Gal Epitope of Pig into H Antigen", Transplantation Proceedings 28:553. |
Sandrin MS et al., 1996 "Reduction of the Major Porcine Xenoantigen Gal.alpha.(1,3)Gal by Expression of .alpha.(1,2)fucosyltransferase", Xenotransplantation 3:134-140. |
Sharma, A. et al., 1996, "Reduction in the Level of Gal(.alpha.1,3)Gal in Transgenic Mice and Pigs by the Expression of an .alpha.(1,2)fucosyltransferase", PNAS 93:7190-7195. |
Saneshige et al., 1995, "Retinoic Acid Directly Stimulates Osteoclastic Bone Resorption and Gene Expression of Cathepsin K/OC-2", Biochem. J. 309:721-724. |