Claims
- 1. A method of preventing the occurrence, or limiting the size, of a region of substantially complete cell death in the brain due to focal ischemic injury, comprising: selecting a mammal that has suffered, or who is at risk of suffering, such a region of substantially complete cell death, and administering bFGF to said mammal intravenously in sufficient dosage to take effect across the blood-brain barrier to effectively prevent the occurrence or limit the size of said region.
- 2. The method of claim 1, further comprising selecting a mammal that has suffered, or who is at risk of suffering, from constriction or obstruction of a single arterial blood vessel in the brain.
- 3. The method of claim 1, further comprising selecting a mammal that has suffered, or who is at risk of suffering, from hemorrhage into the brain.
- 4. The method of claim 3, wherein said hemorrhage is caused by hypertension, hypertensive cerebral vascular disease, trauma, rupture of aneurysms, angiomas, blood dyscrasias, or bleeding from tumors.
Parent Case Info
This application is a 371 of PCT/US 92/09618, filed Nov. 6, 1992, which is a continuation-in-part of U.S. application Ser. No. 07/790,734, filed Nov. 8, 1991, now abandoned entitled "Intravenous Methods and Pharmaceutical Composition of Neurotrophic Factors For Treatment of Neuronal Damage Associated with Ischemia, Hypoxia or Neurodegeneration", pending.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US92/09618 |
11/6/1992 |
|
|
3/16/1995 |
3/16/1995 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO93/08828 |
5/13/1993 |
|
|
US Referenced Citations (4)
Foreign Referenced Citations (1)
Number |
Date |
Country |
930882 |
Jun 1993 |
WOX |
Non-Patent Literature Citations (4)
Entry |
R. Morrison et al. PNAS, 83, 7532-7541, 1986. |
Walicke et al., Experimental Neurology, 102, 144-48, 1988. |
FiscHer et al. Nature: vol. 329(3) pp. 65-68, (1987). |
Remington's Pharmaceutical Science, 16 pp. 759-760. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
790734 |
Nov 1991 |
|