Claims
- 1. A method for treating inflammation in a subject which comprises administering to the subject soluble receptor for advanced glycation end product (sRAGE) (SEQ ID NO: 1) in an amount effective to treat inflammation in the subject.
- 2. A method for treating inflammation in a subject which comprises administering to the subject a polypeptide consisting essentially of the V-domain (SEQ ID NO: 2) of receptor for advanced glycation end product (RAGE) in an amount effective to treat inflammation in the subject.
- 3. A method for treating inflammation in a subject which comprises administering to the subject an agent in an amount which inhibits the interaction between receptor for advanced glycation end product (RAGE) and its ligand thereby treating inflammation in the subject.
- 4. The method of claim 3, wherein the agent comprises a polypeptide, a peptidomimetic, an organic molecule, a carbohydrate, a lipid, an antibody or a nucleic acid.
- 5. The method of claim 4, wherein the polypeptide comprises an advanced glycation end product polypeptide or a portion thereof, a receptor for an advanced glycation end product polypeptide or a portion thereof, a soluble receptor for advanced glycation end product polypeptide or a portion thereof.
- 6. The method of claim 4, wherein the antibody comprises an anti-RAGE antibody or an anti-RAGE F(ab′)2 fragment.
- 7. The method of any one of claims 1 to 3, wherein the subject is a mammal.
- 8. The method of claim 7, wherein the mammal is a human.
- 9. The method of any one of claims 1 to 3, wherein the administration comprises intralesional, intraperitoneal, intramuscular or intravenous injection; infusion; liposome-mediated delivery; topical, nasal, oral, anal, ocular or otic delivery.
- 10. The method of claim 3, wherein the agent is administered daily.
- 11. The method of any one of claims 1 to 3, wherein the amount comprises a dose of from about 200 ng/day/kg body weight to about 200,000 ng/day/kg body weight.
- 12. The method of any one of claims 1 to 3, wherein the inflammation is associated with a wound in the subject.
- 13. The method of any one of claims 1 to 3, wherein the inflammation is associated with periodontal disease in the subject.
- 14. The method of any one of claims 1 to 2, wherein the inflammation is associated with an autoimmune disease in the subject.
- 15. The method of claim 14, wherein the autoimmune disease is multiple sclerosis or autoimmune encepthalitis.
- 16. The method of any one of claims 1 to 3, wherein the inflammation is associated with delayed-type hypersensitivity of a subject.
- 17. The method of any one of claims 1 to 3, wherein the inflammation is associated with arthritis in a subject.
- 18. The method of claim 17, wherein the arthritis comprises collagen-induced arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, arthritis due to Behchet's Syndrome, arthritis due to Sjogren's Syndrome, or arthritis induced by lupus.
- 19. The method of any one of claims 1 to 3, wherein the inflammation is due to colitis in the subject.
- 20. The method of claim 19, wherein the colitis is ulcerative colitis.
- 21. The method of claim 19, wherein the colitis is due to Crohn's disease.
- 22. The method of any one of claims 1 to 3, wherein the subject is suffering from an allergy.
- 23. The method of any one of claims 1 to 3, wherein the subject is suffering from asthma.
- 24. The method of any one of claims 1 to 3, wherein the subject is suffering from diabetes.
- 25. The method of claim 23, wherein the asthma is allergic asthma.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PCT/US99/23303 |
Oct 1999 |
US |
|
Parent Case Info
[0001] This application claims the priority of U.S. Ser. No. 08/755,235, filed Nov. 22, 1996; and U.S. Ser. No. 08/948,131, filed Oct. 9, 1997; and PCT International Application No. PCT/US99/23303 which is continuation-in-part of U.S. Ser. No. 09/263,312, filed Mar. 5, 1999 which is a continuation-in-part of U.S. Ser. No. 09/167,705, filed Oct. 6, 1998, the contents of all of which are hereby incorporated by reference into this application.
Government Interests
[0002] The invention disclosed herein was made with Government support under Grant Nos. HL21006 and AG00603 from the National Institutes of Health, U.S. Department of Health and Human Services. Accordingly, the U.S. Government has certain rights in this invention.