| Baltz, “Vaccines in the treatment of Cancer,” Am. J. Health-Syst. Pharm. (1995), 52:2574-2585. |
| Beckmann et al., “Interaction of Hsp70 with newly synthesized proteins: implications for protein folding and assembly,” Science (1990), 248:850-4. |
| Blachere et al., “Heat Shock Protein Vaccines Against Cancer,” Journal Of Immunotherapy (1993), 14:352-356. |
| Buchner, “Supervising the Fold: Functional Principals of Molecular Chaperones,” The FASEB Journal, vol. 10, pp. 10-19, Jan. 1996. |
| Cai et al, “A Cloned Major Schistosoma mansoni Egg Antigen with Homologies to Small Heat Shock Proteins Elicits Th 1 Responsiveness,” Infection and Immunity (May, 1996), vol. 64, No. 5, pp. 1750-1755. |
| Chopra et al., “TH1 pattern of cytokine secretion by splenic cells from pyelonephritic mice after in-vitro stimulation with hsp-65 of Escherichia coli,” J. Med. Microbiology (Aug. 1997), vol. 84, No. 2, pp. 103-106. |
| Cohen, Irun R., “Short Anayltical Review: The Th1/Th2 Dichotomy, hsp60 Autoimmunity, and Type 1 Diabetes,” Clinical Immunology and Immunopathology (1997), vol. 46, pp. 139-144. |
| Frankel, “Advances in Immunotoxin Biology and Therapy: A summary of the Fourth International Symposium on Immunitoxins.” Cancer Research (1996), 56:926-932. |
| Gao et al., “Characterization of Nucleotide-Free Uncoating ATPase and Its Binding to ATP, ADP, and ATP Analogues,” Biochemistry (1994), 33:2048-2054. |
| Gao et al., “Effect of Constitutive 70-kDa Heat Shock Protein Polymerization on Its Interaction with Protein Substrate” in The Journal of Biological Chemistry, vol. 271 (1996), 28: 16792-16797. |
| Gao et al., “Interaction of Nucleotide-Free HSC70 with Clathrin and Peptide and Effect of ATP Analogues,” Biochemistry (1995) 34:11882-11888. |
| Gao et al., “Nucleotide Binding Properties of Bovine Brain Uncoating ATPase,” The Journal of Biological Chemistry (1993), 269:8507-8513. |
| Georgopoulos et al., “Role of the Major Heat Shock Proteins as Molecular Chaperones,” Annu. Rev. Cell Biol. 1993, pp. 602-634. |
| Gjertsen et al., “Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation,” Lancet (1995), 346:1399-1400. |
| Greene et al., Disassociation of Clathrin from Coated Vesicles by the Uncoating ATPase, Journal of Biological Chemistry (1990), 265:6682-6687. |
| Greene et al., “Effect of Nucleotide on the Binding of Peptides to 70-kDA Heat Shock Protein,” Journal of Biological Chemistry (1995), 70:2967-2973. |
| Ha et al., ATPase Kinetics of Recombinant Bovine 70 kDA Heat Shock Cognate Protein and Its Amino-Terminal ATPase Domain, Biochemistry, (1994), 33:14625-14635. |
| Heike et al., “Heat shock protein-peptide complexes for use in vaccines,” Journal of Leukocyte Biology (1996), 60:153-8. |
| Kelleher et al., “Safety and immunogenicity of UB1 HIV-IMN octameric V3 peptide vaccine administered by subcutaneous injection,” AIDS Research & Human Retroviruses (1997), 13:29-32. |
| Kolb et al., “Cytokine Gene-Expression in the BE Rat Pancreas: Natural Course and Impact of Bacterial Vaccines,” Diabetologia (Dec. 1996), vol. 39, No. 12, pp. 1448-1454. |
| Kohno et al. “Regulation of Cytokine Production by Sugi Allergen-Pullulan Conjugate,” Cellular Immunololgy (Oct. 1995), 168: 211-219. |
| Kuby, J., Immunology, (New York: W. H. Freeman, 1994) p. 432. |
| Lefkovits, Immunological Methods Manual, vol. 2, Chapter 9.11, (San Diego: Academic Press, 1997). |
| Lehninger, Biochemistry, (New York: Worth Publishers, 1970), p. 299. |
| Li et al., “A Critical Contemplation on the Roles of Heat Shock Proteins in Transfer of Antigenic Peptides During Antigen Presentation,” Behring Inst. Mitt. (1994), 94:37-47. |
| Li et al., “Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation,” The EMBO Journal, vol. 12, No. 8 (1993), 3143-3151. |
| Matzinger, “An Innate Sense of Danger,” Immunology (1998), 10:399-415. |
| Matzinger et al., “Tolerance, danger, and the extended family,” Annual Review of Immunology, (1994), vol. 12, pp. 991-1045. |
| Minami et al., “Regulation of the Heat-Shock Protein 70 Reaction Cycle by the Mammalian DnaJ Homolog, HSP40,” Journal of Biological Chemistry (1999)271:19617-19624. |
| Mitra et al., “HLA-DR Polymorphism Modulates the Cytokine Profile of Mycobacterium leprae HSP-Reactive CD4+T Cells,” Clinical Immunology and Immunopathology (Jan. 1997), vo. 82, pp. 60-67. |
| Moseley, “Mechanisms of heat adaptation: Thermotolerance and acclimization” in J. Lab. Clin. Med. (1994), 123:48-52. |
| Nandan et al., “A rapid single-step purification method for immunogenic members of the hsp family: validation and application,” Journal of Immunological Methods (1994), 176:255-263. |
| Old, “Immunotherapy for cancer,” Scientific American (1996), 275:142. |
| Palleros et al., “hsp70-Protein Complexes” in The Journal of Biological Chemistry, vol. 269 (1994), 18:13107-13114. |
| Palleros et al., “Interaction of hsp70 with unfolded proteins: Effects of temperatures and nucleotides on the kinetics of binding” in Proc. Natl. Acad. Sci. (Jul. 1991), 88:5719-5723. |
| Peng et al., “Purification of immunogenic heat shock protein70-peptide complexes by ADP-affinity chromatography,” Journal of Immunological Methods (1997), 204: 13-21. |
| Polla et al., “Presence of hsp65 in bacterial extracts (OM-89): a possible mediator of orally-induced tolerance,” Experientia 51 (1995), Birkhauser Verlag, CH-4010 Basel/Switzerland, pp. 775-779. |
| Prasad et al., “Complex Formation between Clathrin and Uncoated ATPase,” Journal of Biological Chemistry, (1994) 269:6931-6939. |
| Roman et al., “Delayed-type hypersensitivity elicited by synthetic peptides complexed with mycobacterial tuberculosis hsp70,” Immunology, (1997), 90:52-56). |
| Roman et al., “Synthetic peptides non-covalently bound to bacterial hsp70 elicit peptide specific T-cell response in vivo,” Immunology, (1996), 88:487-492. |
| Sadis et al., “Unfolded Proteins Stimulate Molecular Chaperone Hsc70 ATPase by Acclerating ADP/ATP Exchange,” Biochemistry, (1992) 9406-9412. |
| Srivastava et al., “Heat shock protein-peptide complexes in cancer immunotherapy,” Current Opinion in Immunology (1994), 6:728-732. |
| Srivastava, “Heat shock proteins in immune responses to cancer: the fourth paradigm,” Experientia (1994), 50:1054-1060. |
| Srivastava et al., “Heat shock proteins transfer peptides during antigen processing and CTL priming,” Immunogenetics (1994), 39:93-98. |
| Srivastava, “Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum: Role in Immune Response to Cancer and in Antigen Presentation,” Advances in Cancer Research (1993), 62:153-177. |
| Srivastava, “Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens,” Immunology Methods Manual (1997)738-748. |
| Tamura et al, “Immunotherapy oftumors with autologous tumor-derived heat shock protein preparations,” Science (1997), 278, 117-120. |
| Udono et al., “Comparison of Tumor-Specific Immunogenicities of Stress-Induced Proteins gp96, hsp90, and hsp 70,” Journal of Immunology (1994), 5398-5403. |
| Udono et al., “Heat Shock Protein 70-associated Peptides Elicit Specific Cancer Immunity,” J. Exp. Med. (1993), 178:1391-1396. |
| Welch et al., “Rapid Purificaiton of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides,” Molecular and Cellular Biology (Jun. 1985), 1229-1237. |
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