Claims
- 1. A method of detecting an angiogenesis-associated transcript in a cell in a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridized to a sequence at least 80% identical to a sequence as shown in Tables 1-8.
- 2. The method of claim 1, wherein the biological sample is a tissue sample.
- 3. The method of claim 1, wherein the biological sample comprises isolated nucleic acids.
- 4. The method of claim 3, wherein the nucleic acids are mRNA.
- 5. The method of claim 3, further comprising the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide.
- 6. The method of claim 1, wherein the polynucleotide comprises a sequence as shown in Tables 1-8.
- 7. The method of claim 1, wherein the polynucleotide is labeled.
- 8. The method of claim 7, wherein the label is a fluorescent label.
- 9. The method of claim 1, wherein the polynucleotide is immobilized on a solid surface.
- 10. The method of claim 1, wherein the patient is undergoing a therapeutic regimen to treat a disease associated with angiongenesis.
- 11. The method of claim 1, wherein the patient is suspected of having cancer.
- 12. An isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1-8.
- 13. The nucleic acid molecule of claim 12, which is labeled.
- 14. The nucleic acid of claim 13, wherein the label is a fluorescent label
- 15. An expression vector comprising the nucleic acid of claim 12.
- 16. A host cell comprising the expression vector of claim 15.
- 17. An isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1-8
- 18. An antibody that specifically binds a polypeptide of claim 17.
- 19. The antibody of claim 18, further conjugated or fused to an effector component.
- 20. The antibody of claim 19, wherein the effector component is a fluorescent label.
- 21. The antibody of claim 19, wherein the effector component is a radioisotope.
- 22. The antibody of claim 19, which is an antibody fragment.
- 23. The antibody of claim 19, which is a humanized antibody
- 24. A method of detecting a cell undergoing angiogenesis in a biological sample from a patient, the method comprising contacting the biological sample with an antibody of claim 18.
- 25. The method of claim 24, wherein the antibody is further conjugated or fused to an effector component.
- 26. The method of claim 25, wherein the effector component is a fluorescent label.
- 27. The method of detecting antibodies specific to angiogenesis in a patient, the method comprising contacting a biological sample from the patient with a polypeptide which is encoded by a nucleotide sequence of Tables 1-8.
CROSS-REFERENCES TO RELATED APPLICATIONS
[0001] This application claims priority to U.S. Ser. No 09/784,356, filed Feb. 14, 2001; U.S. Ser. No. 09/791,390, filed Feb. 22, 2001; U.S. Ser. No. 60/310,025, filed Aug. 3, 2001, and U.S. Ser. No. 60/334,244, filed Nov. 29, 2001, each of which is herein incorporated by reference in its entirety.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60310025 |
Aug 2001 |
US |
|
60334244 |
Nov 2001 |
US |