Methods of diagnosis of Hepatitis C infection, compositions and methods of screening for modulators of Hepatitis C infection

Abstract

Described herein are genes whose expression are up-regulated or down-regulated during the course of Hepatitis C infection, or distinction between treatment response. Related methods and compositions that can be used for diagnosis and treatment of Hepatitis C infection and/or its secondary consequences are disclosed. Also described herein are methods that can be used to identify modulators of Hepatitis C infection and/or its secondary consequences.

Description

FIELD OF THE INVENTION

[0002] The invention relates to the identification of nucleic acid and protein expression profiles and nucleic acids, products, and antibodies thereto that are involved in Hepatitis C infection; and to the use of such expression profiles to identify compositions relevant in the diagnosis, prognosis, and therapy of Hepatitis C infection and its secondary consequences. The invention further relates to methods for identifying and using agents and/or targets that inhibit Hepatitis C infection or the effects therefrom.

BACKGROUND OF THE INVENTION

[0003] Hepatitis C virus (HCV) infects an estimated 170 million persons worldwide and thus, represents a viral pandemic that is five times as widespread as infection with the Human immunodeficiency-1 virus (HIV-1). In the United States alone an estimated 2.7 million Americans have active HCV infections.

[0004] Sexual transmission of the virus is an inefficient means of infection, rather, the factors most strongly associated with infection are injection drug use and before 1990, receipt of blood transfusion. In some cases no risk factors can be identified. Fortunately, introduction in 1990 and 1992 of improved blood screening measures, based on the detection of HCV antibodies, dramatically decreased the risk of transfusion associated HCV infection.

[0005] HCV is a positive strand RNA virus that belongs to the family of Flavivirus. The natural targets of HCV are the hepatocytes and possibly also B lymphocytes. The genome is about 9400 nucleotides in length and encodes a single large polyprotein of about 3000 amino acids which undergoes proteolysis to form the mature viral proteins. Structural components include the core and two envelope proteins. Two of the regions of the envelope E2 protein, designated hypervariable regions 1 and 2 have an extremely high rate of mutation, believed to be the result of selective pressure by virus specific antibodies. Because the virus is highly mutable and evolves over the course of infection, therapies directed solely at targeting an immune response toward the virus can be ineffective in clearing the viral load. See, e.g., Lauer and Walker (2001) “Hepatitis C Virus Infection” N. E. J. Med. 345:41-52.

[0006] In most persons who become infected with HCV, viremia persists indefinitely and is accompanied by variable degrees of hepatic inflammation and fibrosis. HCV infection is rarely diagnosed during the acute phase of infection when the possibility of viral clearance is greatest. Clinical manifestations of HCV infection usually occur between 2-26 weeks after exposure to HCV, but the majority of persons are asymptomatic. The symptoms that do sometimes accompany acute HCV infection are usually mild and, when present, consist of jaundice, malaise, and nausea. In most cases, acute infection leads to chronic infection which is typically characterized by a prolonged period in which there are no symptoms. Once chronic infection has been established, spontaneous clearance of viremia is rare.

[0007] Viral clearance is associated with the development and persistence of strong virus-specific responses by cytotoxic T lymphocytes and helper T cells. The relatively weak response of cytotoxic T lymphocytes in persons with chronic HCV infection while insufficient to contain viremia and genetic evolution of the virus is still sufficient to cause collateral damage through the elaboration of inflammatory cytokines in the liver. The constant low level inflammatory response leads to hepatitis in most cases of chronic infection and also to some degree of fibrosis which may, in turn, be accompanied by relatively non-specific symptoms such as fatigue. Cirrhosis develops in 15-20% of those individuals who are chronically infected with HCV and these individuals are at high risk for developing severe complications, such as hepatic carcinoma. In fact, once cirrhosis is established, the risk of hepatocellular carcinoma is approximately 1-4% per year.

[0008] In addition to hepatic disease, there are important extrahepatic manifestations of HCV infection. Most of these syndromes are associated with autoimmune or lymphoproliferative states and may be related to the possibility that HCV is able to replicate in lymphoid cells. For example, a higher incidence of non-Hodgkin's Lymphoma has been observed in HCV infection.

[0009] Clearly, a need exists for the identification of novel therapeutic targets and diagnostic markers of HCV infection. Early diagnosis improves the chances that an individual will be able to clear the virus before infection becomes chronic. But, since most infections do become chronic, it is worthwhile to pursue alternative therapies which can be directed at alleviating the continuous low level inflammatory response that accompanies HCV infection and other secondary consequences of HCV infection such as liver fibrosis, which in turn, leads ultimately to cirrhosis and hepatocellular carcinoma.

[0010] Advances in molecular medicine will facilitate elucidation of a role for novel proteins and compounds in disease states. Identification of therapeutic targets and diagnostic markers is essential for improving the current treatment of Hepatitis C infected patients. Accordingly, provided herein are molecular targets for therapeutic intervention in all aspects of Hepatitis C infection. Additionally, provided herein are methods that can be used in diagnosis and prognosis of Hepatitis C infection and/or it secondary consequences. Further provided are methods that can be used to screen candidate bioactive agents for the ability to modulate Hepatitis C infection and/or its secondary consequences.

[0011] The current therapeutic regimen for HCV infection is treatment with interferon alpha (IFN-α). See, e.g., Berkow, The Merck Manual. In chronic hepatitis C, interferon-α at a dosage of 3 million IU subcutaneous three times weekly initially suppresses inflammation in about 50% of patients. Responders are usually treated for 12 months, but most relapse when treatment is stopped; successful long-term disease suppression is only about 20 to 25% overall. Response depends in part on the viral load, viral genotype, and histological state of the disease. Combination therapy with interferon plus oral Ribavirin™ (1200 mg daily in 2 divided doses) may give a higher rate of sustained response. In addition to having limited efficacy, interferon is expensive, must be given by injection, produces bothersome flu-like side effects in most patients, and induces more serious side effects in a minority of cases. Treatment should be supervised by a specialist. Other antiviral and immunomodulatory drugs against HCV have been evaluated or are being studied, but none has shown much promise except the combination of interferon plus ribavirin™.

[0012] Thus, means to early diagnose infection, and to identify patients who are likely to respond to treatment with IFN-α would be useful. Prognosis of response to treatment will minimize the occurrence of negative side effects in those patients who will not respond, and will allow early application of alternative therapies early in the infection. The present invention provides these and many other important capabilities.

SUMMARY OF THE INVENTION

[0013] The present invention therefore provides nucleotide sequences of genes that are up- and down-regulated in Hepatitis C infected cells and in cells affected indirectly by Hepatitis C infection. Such genes are useful for diagnostic purposes, and also as targets for screening for therapeutic compounds that modulate Hepatitis C infection and/or its secondary consequences, such as hormones or antibodies. Other aspects of the invention will become apparent to the skilled artisan by the following description of the invention.

[0014] In one aspect, the present invention provides a method of detecting a RNA transcript associated with Hepatitis C infection, in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15.

[0015] In one embodiment, the present invention provides a method of determining the level of a Hepatitis C infection associated transcript in a cell from a patient.

[0016] In one embodiment, the present invention provides a method of detecting a Transcript associated with Hepatitis C infection in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15.

[0017] In one embodiment, the polynucleotide selectively hybridizes to a sequence at least 95% identical to a sequence as shown in Tables 1A-15.

[0018] In one embodiment, the biological sample is a tissue sample, e.g., a liver biopsy. In another embodiment, the biological sample comprises isolated nucleic acids, e.g., mRNA.

[0019] In one embodiment, the polynucleotide is labeled, e.g., with a fluorescent label.

[0020] In one embodiment, the polynucleotide is immobilized on a solid surface.

[0021] In one embodiment, the patient is undergoing a therapeutic regimen to treat Hepatitis C infection.

[0022] In one embodiment, the patient is a primate or human.

[0023] In one embodiment, the Hepatitis C associated transcript is mRNA.

[0024] In one embodiment, the method further comprises the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide.

[0025] In another aspect, the present invention provides a method of monitoring the efficacy of a therapeutic treatment for Hepatitis C infection and/or its secondary consequences, the method comprising steps of: (i) providing a biological sample from a patient undergoing the therapeutic treatment; and (ii) determining the level of a Transcript associated with Hepatitis C infection in the biological sample by contacting the biological sample with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15, thereby monitoring the efficacy of the therapy. In a further embodiment, the patient has a drug resistant form of Hepatitis C infection.

[0026] In one embodiment, the method further comprises a step of: (iii) comparing the level of the RNA transcript associated with Hepatitis C infection to a level of the Transcript associated with Hepatitis C infection in a biological sample from the patient prior to, or earlier in, the therapeutic treatment.

[0027] Additionally, provided herein is a method of evaluating the effect of a candidate drug for treating Hepatitis C infection and/or its secondary consequences, comprising administering drug to a patient and removing a cell sample from the patient. The expression profile of the cell is then determined. This method may further comprise comparing the expression profile to an expression profile of a healthy individual or other comparison sample. In a preferred embodiment, said expression profile includes a gene of Tables 1A-15.

[0028] In one aspect, the present invention provides an isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1A-15.

[0029] In one embodiment, an expression vector or cell comprises the isolated nucleic acid.

[0030] In one aspect, the present invention provides an isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1A-15.

[0031] In another aspect, the present invention provides an antibody that specifically binds to an isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1A-15.

[0032] In one embodiment, the antibody is conjugated to an effector component, e.g., a fluorescent label, a radioisotope, or a cytotoxic chemical.

[0033] In one embodiment, the antibody is an antibody fragment. In another embodiment, the antibody is humanized.

[0034] In one aspect, the present invention provides a method of detecting a Hepatitis C infected cell or a cell affected secondarily by Hepatitis C infection in a biological sample from a patient, the method comprising contacting the biological sample with an antibody as described herein.

[0035] In another aspect, the present invention provides a method of detecting antibodies specific to Hepatitis C infection in a patient, the method comprising contacting a biological sample from the patient with a polypeptide encoded by a nucleic acid comprising a sequence from Tables 1A-15.

[0036] In another aspect, the present invention provides a method for identifying a compound that modulates a Hepatitis C infection-associated polypeptide, the method comprising steps of: (i) contacting the compound with a Hepatitis C infection-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15; and (ii) determining the functional effect of the compound upon the polypeptide.

[0037] In one embodiment, the functional effect is a physical effect, an enzymatic effect, a physiological effect, or a chemical effect.

[0038] In one embodiment, the polypeptide is expressed in a eukaryotic host cell or cell membrane. In another embodiment, the polypeptide is recombinant.

[0039] In one embodiment, the functional effect is determined by measuring ligand binding to the polypeptide.

[0040] In another aspect, the present invention provides a method of inhibiting proliferation of a Hepatitis C infected or a cell secondarily affected by Hepatitis C infection to treat Hepatitis C infection in a patient, the method comprising the step of administering to the subject a therapeutically effective amount of a compound identified as described herein.

[0041] In one embodiment, the compound is an antibody, e.g., one or more monoclonal antibodies.

[0042] In another aspect, the present invention provides a drug screening assay comprising steps of: (i) administering a test compound to a mammal suffering from a Hepatitis C infection or to a cell sample isolated therefrom; (ii) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15 in a treated cell or mammal with the level of gene expression of the polynucleotide in a control cell sample or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of Hepatitis C infection and/or its secondary consequences.

[0043] In one embodiment, the control is a mammal, e.g., primate, infected with Hepatitis C virus or a cell sample therefrom that has not been treated with the test compound. In another embodiment, the control is a normal cell or mammal.

[0044] In one embodiment, the test compound is administered in varying amounts or concentrations. In another embodiment, the test compound is administered for varying time periods. In another embodiment, the comparison can occur before or after addition or removal of the drug candidate.

[0045] In one embodiment, the levels of a plurality of polynucleotides that selectively hybridize to a sequence at least 80% identical to a sequence as shown in Tables 1A-15 are individually compared to their respective levels in a control cell sample or mammal. In a preferred embodiment the plurality of polynucleotides is from three to ten.

[0046] In another aspect, the present invention provides a method for treating a mammal infected with Hepatitis C virus comprising administering a compound identified by the assay described herein.

[0047] In another aspect, the present invention provides a pharmaceutical composition for treating a mammal, e.g., primate, infected with Hepatitis C virus, the composition comprising a compound identified by the assay described herein and a physiologically acceptable excipient.

[0048] In one aspect, the present invention provides a method of screening drug candidates by providing a cell expressing a gene that is up- or down-regulated as in a Hepatitis C infection. In one embodiment, a gene is selected from Tables 1A-15. The method further includes adding a drug candidate to the cell and determining the effect of the drug candidate on the expression of the expression profile gene.

[0049] In one embodiment, the method of screening drug candidates includes comparing the level of expression in the absence of the drug candidate to the level of expression in the presence of the drug candidate, wherein the concentration of the drug candidate can vary when present, and wherein the comparison can occur after addition or removal of the drug candidate. In a preferred embodiment, the cell expresses at least two or more expression profile genes. The profile genes may each show change, e.g., an increase or decrease.

[0050] Also provided is a method of evaluating the effect of a candidate drug for the treatment of Hepatitis C infection and/or its secondary consequences comprising administering the drug to a transgenic animal expressing or over-expressing the Hepatitis C infection modulatory protein, or an animal lacking the Hepatitis C infection modulatory protein, e.g., as a result of a gene knockout.

[0051] Moreover, provided herein is a biochip comprising one or more nucleic acid segments of Tables 1A-15, wherein the biochip comprises fewer than 1000 nucleic acid probes. Preferably, at least two nucleic acid segments are included. More preferably, at least three nucleic acid segments are included.

[0052] Furthermore, a method of diagnosing a disorder associated with Hepatitis C infection is provided. The method comprises determining the expression of a gene of Tables 1A-15, in a first tissue type of a first individual, and comparing the distribution to the expression of the gene from a second uninfected individual. A difference in the expression indicates that the first individual has a disorder associated with Hepatitis C infection.

[0053] In a further embodiment, the biochip also includes a polynucleotide sequence of a gene that is not changed, e.g., up- or down-regulated in Hepatitis C infection.

[0054] In one embodiment a method for screening for a bioactive agent capable of interfering with the binding of a Hepatitis C infection modulating protein (Hepatitis C infection modulatory protein) or a fragment thereof and an antibody which binds to said Hepatitis C infection modulatory protein or fragment thereof. In a preferred embodiment, the method comprises combining a Hepatitis C infection modulatory protein or fragment thereof, a candidate bioactive agent, and an antibody which binds to said Hepatitis C infection modulatory protein or fragment thereof. The method further includes determining the binding of said Hepatitis C infection modulatory protein or fragment thereof and said antibody. When there is a change in binding, an agent is identified as an interfering agent. The interfering agent can be an agonist or an antagonist. Preferably, the agent inhibits Hepatitis C infection and/or the secondary consequences of Hepatitis C infection.

[0055] Also provided herein are methods of modulating an immune response in an individual, e.g., primate. In one embodiment a method provided herein comprises administering to an individual a composition comprising a Hepatitis C infection modulating protein, or a fragment thereof. In another embodiment, the protein is encoded by a nucleic acid selected from those of Tables 1A-15.

[0056] Further provided herein are compositions capable of eliciting an immune response in an individual. In one embodiment, a composition provided herein comprises a Hepatitis C infection modulating protein, preferably encoded by a nucleic acid of Tables 1A-15, or a fragment thereof, and a pharmaceutically acceptable carrier. In another embodiment, said composition comprises a nucleic acid comprising a sequence encoding a Hepatitis C infection modulating protein, preferably selected from the nucleic acids of Tables 1A-15, and a pharmaceutically acceptable carrier.

[0057] Also provided are methods of neutralizing the effect of a protein associated with Hepatitis C infection and/or its secondary consequences, or a fragment thereof, comprising contacting an agent specific for said protein with said protein in an amount sufficient to effect neutralization. In another embodiment, the protein is encoded by a nucleic acid selected from those of Tables 1A-15.

[0058] In another aspect of the invention, a method of treating an individual infected with Hepatitis C is provided. In one embodiment, the method comprises administering to said individual, e.g., primate, an inhibitor of a Hepatitis C infection modulating protein. In another embodiment, the method comprises administering to a patient, e.g., primate, infected with Hepatitis C virus, an antibody to a Hepatitis C infection modulating protein conjugated to a therapeutic moiety. Such a therapeutic moiety can be a cytotoxic agent or a radioisotope.

DETAILED DESCRIPTION OF THE INVENTION

[0059] In accordance with the objects outlined above, the present invention provides novel methods for diagnosis and prognosis evaluation for Hepatitis C infection and/or its secondary consequences, as well as methods for screening for compositions which modulate Hepatitis C infection and/or its secondary consequences. Markers are identified which correlate with subsets of patients who respond to IFN-α treatment, or with subsets of patients who are retractile (non-responsive) to treatment with standard IFN-α treatment. Also provided are methods for treating Hepatitis C infection and/or its secondary consequences.

[0060] Definitions

[0061] The term “Hepatitis C infection polynucleotide” or “transcript associated with Hepatitis C infection” refers to nucleic acid polymorphic variants, alleles, mutants, and interspecies homologues isolated from cells involved in Hepatitis C infection and/or its secondary consequences, or those which allow for subsetting of infected patients. The cells from which the nucleic acids are isolated include cells such as hepatocytes and B lymphocytes, that are directly infected by virus, as well as cells that may be indirectly affected by the viral infection such as those cells involved in the immune and inflammatory response to Hepatitis C infection. The terms also refer to nucleic acids that: (1) have a nucleotide sequence with greater than about 60% nucleotide sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or greater nucleotide sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more nucleotides, to a nucleotide sequence of or associated with a gene of Tables 1A-15; or, (2) specifically hybridize under stringent hybridization conditions to a nucleic acid sequence, or the complement thereof, of Tables 1A-15 and conservatively modified variants thereof.

[0062] The term “Hepatitis C infection protein” and similar terms refer to polypeptide polymorphic variants, alleles, mutants, and interspecies homologues isolated from cells involved in Hepatitis C infection and its secondary consequences, including ones which allow for subsetting patients, e.g., into responsive or non-responsive subsets. The cells from which the polypeptides are isolated include cells such as hepatocytes and B lymphocytes, that are directly infected by virus, as well as cells that may be indirectly affected by the viral infection such as those cells involved in the immune and inflammatory response to Hepatitis C infection. The terms also refer to polypeptides that: (1) bind to antibodies, e.g., polyclonal antibodies, raised against an immunogen comprising an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1A-15, and conservatively modified variants thereof; or (2) have an amino acid sequence that has greater than about 60% amino acid sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% or greater amino sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more amino acid, to an amino acid sequence encoded by a nucleotide sequence of, or associated with, a gene of Tables 1A-15.

[0063] A polynucleotide or polypeptide sequence is typically from a mammal including, but not limited to, primate, e.g., human; rodent, e.g., rat, mouse, hamster; cow, pig, horse, sheep, or other mammal, domestic or livestock. A “Hepatitis C infection polypeptide” and a “Hepatitis C infection polynucleotide,” include both naturally occurring or recombinant forms.

[0064] A “full length” Hepatitis C infection protein or nucleic acid refers to a Hepatitis C infection polypeptide or polynucleotide sequence, or a variant thereof, that contains all of the elements normally contained in one or more naturally occurring, wild type Hepatitis C infection polynucleotide or polypeptide sequences. The “full length” may be prior to, or after, various stages of post-translational processing or splicing, including alternative splicing.

[0065] “Biological sample” as used herein is a sample of biological tissue or fluid that contains nucleic acids or polypeptides, e.g., of a Hepatitis C infection protein, polynucleotide, or transcript. Such samples include, but are not limited to, tissue isolated from primates, e.g., humans, or rodents, e.g., mice and rats. Biological samples may also include sections of tissues such as biopsy and autopsy samples, frozen sections taken for histologic purposes, archival specimens, blood, plasma, serum, sputum, stool, tears, mucus, hair, skin, etc. Biological samples also include explants and primary and/or transformed cell cultures derived from patient tissues. A biological sample is typically obtained from a eukaryotic organism, most preferably a mammal such as a primate e.g., chimpanzee or human; cow; dog; cat; a rodent, e.g., guinea pig, rat, mouse; rabbit; or a bird; reptile; or fish.

[0066] “Providing a biological sample” means to obtain a biological sample for use in methods described in this invention. Most often, this will be done by removing a sample of cells from an animal, but can also be accomplished by using previously isolated cells (e.g., isolated by another person, at another time, and/or for another purpose), or by performing the methods of the invention in vivo. Archival tissues, having treatment and/or outcome history, will be particularly useful.

[0067] The terms “identical” or percent “identity,” in the context of two or more nucleic acids or polypeptide sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues or nucleotides that are the same (e.g., about 60% identity, preferably 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or higher identity over a specified region, when compared and aligned for maximum correspondence over a comparison window or designated region) as measured using a BLAST or BLAST 2.0 sequence comparison algorithms with default parameters described below, or by manual alignment and visual inspection (see, e.g., NCBI web site http://www.ncbi.nlm.nih.gov/BLAST/ or the like). Such sequences are then said to be “substantially identical.” This definition also refers to, or may be applied to, the complement of a test sequence. The definition also includes sequences that have deletions and/or additions, as well as those that have substitutions, as well as naturally occurring, e.g., polymorphic or allelic variants, and man-made variants. As described below, the preferred algorithms can account for gaps and the like. Preferably, identity exists over a region that is at least about 25 amino acids or nucleotides in length, or more preferably over a region that is 50-100 amino acids or nucleotides in length.

[0068] For sequence comparison, typically one sequence acts as a reference sequence, to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Preferably, default program parameters can be used, or alternative parameters can be designated. The sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.

[0069] A “comparison window”, as used herein, includes reference to a segment of one of the number of contiguous positions selected from the group consisting typically of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150 in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned. Methods of alignment of sequences for comparison are well-known in the art. Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith and Waterman (1981) Adv. Appl. Math. 2:482-489, by the homology alignment algorithm of Needleman and Wunsch (1970) J. Mol. Biol. 48:443-453, by the search for similarity method of Pearson and Lipman (1988) Proc. Nat'l. Acad. Sci. USA 85:2444-2448, by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wis.), or by manual alignment and visual inspection (see, e.g., Ausubel, et al. (eds. 1995 and supplements) Current Protocols in Molecular Biology Lippincott.

[0070] Preferred examples of algorithms that are suitable for determining percent sequence identity and sequence similarity include the BLAST and BLAST 2.0 algorithms, which are described, e.g., in Altschul, et al. (1977) Nuc. Acids Res. 25:3389-3402 and Altschul, et al. (1990) J. Mol. Biol. 215:403-410. BLAST and BLAST 2.0 are used, with the parameters described herein, to determine percent sequence identity for nucleic acids and proteins of the invention. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/). This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighborhood word score threshold (Altschul, et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Cumulative scores are calculated using, e.g., for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always >0) and N (penalty score for mismatching residues; always <0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension of the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative-scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed of the alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N=−4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength of 3, and expectation (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff and Henikoff (1989) Proc. Nat'l Acad. Sci. USA 89:10915-919) alignments (B) of 50, expectation (E) of 10, M=5, N=−4, and a comparison of both strands.

[0071] The BLAST algorithm also performs a statistical analysis of the similarity between two sequences. See, e.g., Karlin and Altschul (1993) Proc. Nat'l. Acad. Sci. USA 90:5873-5787. One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a nucleic acid is considered similar to a reference sequence if the smallest sum probability in a comparison of the test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about 0.01, and most preferably less than about 0.001. Log values may be large negative numbers, e.g., 5, 10, 20, 30, 40, 40, 70, 90, 110, 150, 170, etc.

[0072] An indication that two nucleic acid sequences or polypeptides are substantially identical is that the polypeptide encoded by the first nucleic acid is immunologically cross reactive with the antibodies raised against the polypeptide encoded by the second nucleic acid, as described below. Thus, a polypeptide is typically substantially identical to a second polypeptide, e.g., where the two peptides differ only by conservative substitutions. Another indication that two nucleic acid sequences are substantially identical is that the two molecules or their complements hybridize to each other under stringent conditions, as described below. Yet another indication that two nucleic acid sequences are substantially identical is that the same primers can be used to amplify the sequences.

[0073] A “host cell” is a naturally occurring cell or a transformed cell that contains an expression vector and supports the replication or expression of the expression vector. Host cells may be cultured cells, explants, cells in vivo, and the like. Host cells may be prokaryotic cells such as E. coli, or eukaryotic cells such as yeast, insect, amphibian, or mammalian cells such as CHO, HeLa, and the like (see, e.g., the American Type Culture Collection catalog or web site, www.atcc.org).

[0074] The terms “isolated,” “purified,” or “biologically pure” refer to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. A protein or nucleic acid that is the predominant species present in a preparation is substantially purified. In particular, an isolated nucleic acid is separated from some open reading frames that naturally flank the gene and encode proteins other than protein encoded by the gene. The term “purified” in some embodiments denotes that a nucleic acid or protein gives rise to essentially one band in an electrophoretic gel. Preferably, it means that the nucleic acid or protein is at least 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure. “Purify” or “purification” in other embodiments means removing at least one contaminant from the composition to be purified. In this sense, purification does not require that the purified compound be homogenous, e.g., 100% pure.

[0075] The terms “polypeptide,” “peptide”, and “protein” are used interchangeably herein to refer to a polymer of amino acid residues. The terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers, those containing modified residues, and non-naturally occurring amino acid polymer.

[0076] The term “amino acid” refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function similarly to the naturally occurring amino acids. Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline, γ-carboxyglutamate, and O-phosphoserine. Amino acid analogs refers to compounds that have the same basic chemical structure as a naturally occurring amino acid, e.g., an α carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs may have modified R groups (e.g., norleucine) or modified peptide backbones, but retain the same basic chemical structure as a naturally occurring amino acid. Amino acid mimetics refers to chemical compounds that have a structure that is different from the general chemical structure of an amino acid, but that functions similarly to a naturally occurring amino acid.

[0077] Amino acids may be referred to herein by either their commonly known three letter symbols or by the one-letter symbols recommended by the IUPAC-IUB Biochemical Nomenclature Commission. Nucleotides, likewise, may be referred to by their commonly accepted single-letter codes.

[0078] “Conservatively modified variants” applies to both amino acid and nucleic acid sequences. With respect to particular nucleic acid sequences, conservatively modified variants refers to those nucleic acids which encode identical or essentially identical amino acid sequences, or where the nucleic acid does not encode an amino acid sequence, to essentially identical or associated, e.g., naturally contiguous, sequences. Because of the degeneracy of the genetic code, a large number of functionally identical nucleic acids encode most proteins. For instance, the codons GCA, GCC, GCG, and GCU all encode the amino acid alanine. Thus, at every position where an alanine is specified by a codon, the codon can be altered to another of the corresponding codons described without altering the encoded polypeptide. Such nucleic acid variations are “silent variations,” which are one species of conservatively modified variations. Every nucleic acid sequence herein which encodes a polypeptide also describes silent variations of the nucleic acid. One of skill will recognize that in certain contexts each codon in a nucleic acid (except AUG, which is ordinarily the only codon for methionine, and TGG, which is ordinarily the only codon for tryptophan) can be modified to yield a functionally identical molecule. Accordingly, often silent variations of a nucleic acid which encodes a polypeptide is implicit in a described sequence with respect to the expression product, but not with respect to actual probe sequences.

[0079] As to amino acid sequences, one of skill will recognize that individual substitutions, deletions, or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters, adds or deletes a single amino acid or a small percentage of amino acids in the encoded sequence is a “conservatively modified variant” where the alteration results in the substitution of an amino acid with a chemically similar amino acid. Conservative substitution tables providing functionally similar amino acids are well known in the art. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles of the invention. Typically conservative substitutions include for one another: 1) Alanine (A), Glycine (G); 2) Aspartic acid (D), Glutamic acid (E); 3) Asparagine (N), Glutamine (O); 4) Arginine (R), Lysine (K); 5) Isoleucine (I), Leucine (L), Methionine (M), Valine (V); 6) Phenylalanine (F), Tyrosine (Y), Tryptophan (W); 7) Serine (S), Threonine (T); and 8) Cysteine (C), Methionine (M). See, e.g., Creighton (1984) Proteins: Structure and Molecular Properties Freeman.

[0080] Macromolecular structures such as polypeptide structures can be described in terms of various levels of organization. For a general discussion of this organization, see, e.g., Alberts, et al. (1994) Molecular Biology of the Cell (3d ed.) Garland; and Cantor and Schimmel (1980) Biophysical Chemistry Part I: The Conformation of Biological Macromolecules Freeman. “Primary structure” refers to the amino acid sequence of a particular peptide. “Secondary structure” refers to locally ordered, three dimensional structures within a polypeptide. These structures are commonly known as domains. Domains are portions of a polypeptide that often form a compact unit of the polypeptide and are typically about 25-500 amino acids long. Typical domains are made up of sections of lesser organization such as stretches of β-sheet and α-helices. “Tertiary structure” refers to the complete three dimensional structure of a polypeptide monomer. “Quaternary structure” refers to the three dimensional structure formed, usually by the noncovalent association of independent tertiary units. Anisotropic terms are also known as energy terms.

[0081] “Nucleic acid” or “oligonucleotide” or “polynucleotide” or grammatical equivalents used herein means at least two nucleotides covalently linked together. Oligonucleotides are typically from about 5, 6, 7, 8, 9, 10, 12, 15, 25, 30, 40, 50 or more nucleotides in length, up to about 100 nucleotides in length. Nucleic acids and polynucleotides are a polymers of any length, including longer lengths, e.g., 200, 300, 500, 1000, 2000, 3000, 5000, 7000, 10,000, etc. A nucleic acid of the present invention will generally contain phosphodiester bonds, although in some cases, nucleic acid analogs are included that may have alternate backbones, comprising, e.g., phosphoramidate, phosphorothioate, phosphorodithioate, or O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford Univ. Press); and peptide nucleic acid backbones and linkages. Other analog nucleic acids include those with positive backbones; non-ionic backbones, and non-ribose backbones, including those described in U.S. Pat. Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7 in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids. Modifications of the ribose-phosphate backbone may be done for a variety of reasons, e.g., to increase the stability and half-life of such molecules in physiological environments or as probes on a biochip. Mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.

[0082] A variety of references disclose such nucleic acid analogs, including, for example, phosphoramidate (Beaucage, et al. (1993) Tetrahedron 49:1925-1963 and references therein; Letsinger (1970) J. Org. Chem. 35:3800-3803; Sprinzl, et al. (1977) Eur. J. Biochem. 81:579-589; Letsinger, et al. (1986) Nucl. Acids Res. 14:3487499; Sawai, et al. (1984) Chem. Lett. 805, Letsinger, et al. (1988) J. Am. Chem. Soc. 110:4470-4471; and Pauwels, et al. (1986) Chemica Scripta 26:141-149), phosphorothioate (Mag, et al. (1991) Nuc. Acids Res. 19:1437-441; and U.S. Pat. No. 5,644,048), phosphorodithioate (Brill, et al. (1989) J. Am. Chem. Soc. 111:2321-322), O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach, Oxford Univ. Press), and peptide nucleic acid backbones and linkages (see Egholm (1992) J. Am. Chem. Soc. 114:1895-1897; Meier, et al. (1992) Chem. Int. Ed. Engl. 31:1008-1010; Nielsen (1993) Nature 365:566-568; and Carlsson, et al. (1996) Nature 380:207). Other analog nucleic acids include those with positive backbones (Denpcy, et al. (1995) Proc. Nat'l Acad. Sci. USA 92:6097-101); non-ionic backbones (U.S. Pat. Nos. 5,386,023, 5,637,684, 5,602,240, 5,216,141, and 4,469,863; Kiedrowski, et al. (1991) Angew. Chem. Intl. Ed. English 30:423-426; Letsinger, et al. (1988) J. Am. Chem. Soc. 110:4470-471; Jung, et al. (1994) Nucleoside and Nucleotide 13:1597-xxx; Chapters 2 and 3 in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580; Mesmaeker, et al. (1994) Bioorganic and Medicinal Chem. Lett. 4:395-398; Jeffs, et al. (1994) J. Biomolecular NMR 34:17; and Horn, et al. (1996) Tetrahedron Lett. 37:743-xxx) and non-ribose backbones, including those described in U.S. Pat. Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7 in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids. See Jenkins, et al. (1995) Chem. Soc. Rev. pp 169-176. Several nucleic acid analogs are described in Rawls (page 35, Jun. 2, 1997) C&E News. All of these references are hereby expressly incorporated by reference.

[0083] Particularly preferred are peptide nucleic acids (PNA) which includes peptide nucleic acid analogs. These backbones are substantially non-ionic under neutral conditions, in contrast to the highly charged phosphodiester backbone of naturally occurring nucleic acids. This results in two advantages. First, the PNA backbone exhibits improved hybridization kinetics. PNAs have larger changes in the melting temperature (Tm) for mismatched versus perfectly matched base pairs. DNA and RNA typically exhibit a 2-4° C. drop in Tm for an internal mismatch. With the non-ionic PNA backbone, the drop is closer to 7-9° C. Similarly, due to their non-ionic nature, hybridization of the bases attached to these backbones is relatively insensitive to salt concentration. In addition, PNAs are not degraded by cellular enzymes, and thus can be more stable.

[0084] The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. As will be appreciated by those in the art, the depiction of a single strand also defines the sequence of the complementary strand; thus the sequences described herein also provide the complement of the sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA or a hybrid, where the nucleic acid may contain combinations of deoxyribo- and ribo-nucleotides, and combinations of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc. “Transcript” typically refers to a naturally occurring RNA, e.g., a pre-mRNA, hnRNA, or mRNA. As used herein, the term “nucleoside” includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides. In addition, “nucleoside” includes non-naturally occurring analog structures. Thus, e.g., the individual units of a peptide nucleic acid, each containing a base, are referred to herein as a nucleoside.

[0085] A “label” or a “detectable moiety” is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, chemical, physiological, or other physical means. For example, useful labels include 32P, fluorescent dyes, electron-dense reagents, enzymes (e.g., as commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins or other entities which can be made detectable, e.g., by incorporating a radiolabel into the peptide or used to detect antibodies specifically reactive with the peptide. The labels may be incorporated into the Hepatitis C infection nucleic acids, proteins, and antibodies. Many methods known for conjugating the antibody to the label may be employed. See, e.g., Hunter, et al. (1962) Nature 144:945; David, et al. (1974) Biochemistry 13:1014-1021; Pain, et al. (1981) J. Immunol. Meth. 40:219-230; and Nygren (1982) J. Histochem. and Cytochem. 30:407-412.

[0086] An “effector” or “effector moiety” or “effector component” is a molecule that is bound (or linked, or conjugated), either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds, to an antibody. The “effector” can be a variety of molecules including, e.g., detection moieties including radioactive compounds, fluorescent compounds, an enzyme or substrate, tags such as epitope tags, a toxin; activatable moieties, a chemotherapeutic agent; a lipase; an antibiotic; or a radioisotope emitting “hard” e.g., beta radiation. The effectors may be fusion proteins, or even natural components of antibodies, e.g., Ig constant effector sequences.

[0087] A “labeled nucleic acid probe or oligonucleotide” is one that is bound, either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence of the probe may be detected by detecting the presence of the label bound to the probe. Alternatively, method using high affinity interactions may achieve the same results where one of a pair of binding partners binds to the other, e.g., biotin, streptavidin.

[0088] As used herein a “nucleic acid probe or oligonucleotide” is defined as a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (e.g., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, so long as it does not functionally interfere with hybridization. Thus, e.g., probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. It will be understood by one of skill in the art that probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions. The probes are preferably directly labeled as with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled such as with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of the select sequence or subsequence. Diagnosis or prognosis may be based at the genomic level, or at the level of RNA or protein expression.

[0089] The term “recombinant” when used with reference, e.g., to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified. Thus, e.g., recombinant cells express genes that are not found within the native (non-recombinant) form of the cell or express native genes that are otherwise abnormally expressed, under expressed or not expressed at all. By the term “recombinant nucleic acid” herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid, e.g., using polymerases and endonucleases, in a form not normally found in nature. In this manner, operably linkage of different sequences is achieved. Thus an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate non-recombinantly, e.g., using the in vivo cellular machinery of the host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinantly, although subsequently replicated non-recombinantly, are still considered recombinant for the purposes of the invention. Similarly, a “recombinant protein” is a protein made using recombinant techniques, e.g., through the expression of a recombinant nucleic acid as depicted above.

[0090] The term “heterologous” when used with reference to portions of a nucleic acid indicates that the nucleic acid comprises two or more subsequences that are not normally found in the same relationship to each other in nature. For instance, the nucleic acid is typically recombinantly produced, having two or more sequences, e.g., from unrelated genes arranged to make a new functional nucleic acid, e.g., a promoter from one source and a coding region from another source. Similarly, a heterologous protein will often refer to two or more subsequences that are not found in the same relationship to each other in nature (e.g., a fusion protein).

[0091] A “promoter” is defined as an array of nucleic acid control sequences that direct transcription of a nucleic acid. As used herein, a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element. A promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription. A “constitutive” promoter is a promoter that is active under most environmental and developmental conditions. An “inducible” promoter is a promoter that is active under environmental or developmental regulation. The term “operably linked” refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or array of transcription factor binding sites) and a second nucleic acid sequence, wherein the expression control sequence directs transcription of the nucleic acid corresponding to the second sequence.

[0092] An “expression vector” is a nucleic acid construct, generated recombinantly or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular nucleic acid in a host cell. The expression vector can be part of a plasmid, virus, or nucleic acid fragment. Typically, the expression vector includes a nucleic acid to be transcribed operably linked to a promoter.

[0093] The phrase “selectively (or specifically) hybridizes to” refers to the binding, duplexing, or hybridizing of a molecule only to a particular nucleotide sequence under stringent hybridization conditions when that sequence is present in a complex mixture (e.g., total cellular or library DNA or RNA).

[0094] The phrase “stringent hybridization conditions” refers to conditions under which a probe will hybridize to its target subsequence, typically in a complex mixture of nucleic acids, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in “Overview of principles of hybridization and the strategy of nucleic acid assays” in Tijssen (1993) Hybridization with Nucleic Probes (Laboratory Techniques in Biochemistry and Molecular Biology) (vol. 24) Elsevier. Generally, stringent conditions are selected to be about 5-10° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength pH. The Tm is the temperature (under defined ionic strength, pH, and nucleic concentration) at which 50% of the probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at Tm, 50% of the probes are occupied at equilibrium). Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotides) and at least about 60° C. for long probes (e.g., greater than 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide. For selective or specific hybridization, a positive signal is at least two times background, preferably 10 times background hybridization. Exemplary stringent hybridization conditions can be as following: 50% formamide, 5×SSC, and 1% SDS, incubating at 42° C., or, 5×SSC, 1% SDS, incubating at 65° C., with wash in 0.2×SSC, and 0.1% SDS at 65° C. For PCR, a temperature of about 36° C. is typical for low stringency amplification, although annealing temperatures may vary between about 32-48° C. depending on primer length. For high stringency PCR amplification, a temperature of about 62° C. is typical, although high stringency annealing temperatures can range from about 50-65° C., depending on the primer length and specificity. Typical cycle conditions for both high and low stringency amplifications include a denaturation phase of 90-95° C. for 30-120 sec, an annealing phase lasting 30-120 sec, and an extension phase of about 72° C. for 1-2 min. Protocols and guidelines for low and high stringency amplification reactions are provided, e.g., in Innis, et al. (1990) PCR Protocols, A Guide to Methods and Applications, Academic Press, NY.

[0095] Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This occurs, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. In such cases, the nucleic acids typically hybridize under moderately stringent hybridization conditions. Exemplary “moderately stringent hybridization conditions” include a hybridization in a buffer of 40% formamide, 1 M NaCl, 1% SDS at 37° C., and a wash in 1×SSC at 45° C. A positive hybridization is at least twice background. Those of ordinary skill will readily recognize that alternative hybridization and wash conditions can be utilized to provide conditions of similar stringency. Additional guidelines for determining hybridization parameters are provided in numerous references, e.g., Ausubel, et al. (eds. 1991 and supplements) Current Protocols in Molecular Biology Lippincott.

[0096] The phrase “functional effects” in the context of assays for testing compounds that modulate activity of a Hepatitis C infection protein includes the determination of a parameter that is indirectly or directly under the influence of the Hepatitis C infection protein or nucleic acid, e.g., a functional, physical, or chemical effect, such as the ability to decrease Hepatitis C infection or its secondary consequences. It includes ligand binding activity; “Functional effects” include in vitro, in vivo, and ex vivo activities.

[0097] By “determining the functional effect” is meant assaying for a compound that modifies, e.g., increases or decreases, a parameter that is indirectly or directly under the influence of a Hepatitis C infection protein sequence, e.g., functional, enzymatic, physical, physiological, or chemical effects. Such functional effects can be measured by any means known to those skilled in the art, e.g., changes in spectroscopic characteristics (e.g., fluorescence, absorbance, refractive index), hydrodynamic (e.g., shape), chromatographic, or solubility properties for the protein, measuring inducible markers or transcriptional activation of the Hepatitis C infection protein; measuring binding activity or binding assays, e.g., binding to antibodies or other ligands, and measuring cellular proliferation. Determination of the functional effect of a compound on Hepatitis C infection and its secondary consequences can also be performed using assays known to those of skill in the art such as an in vitro assays. The functional effects can be evaluated by many means known to those skilled in the art, e.g., measurement of changes in RNA or protein levels for Hepatitis C infection-associated sequences, measurement of RNA stability, identification of downstream or reporter gene expression (CAT, luciferase, β-gal, GFP, and the like), e.g., via chemiluminescence, fluorescence, calorimetric reactions, antibody binding, inducible markers, and ligand binding assays.

[0098] “Inhibitors”, “activators”, and “modulators” of Hepatitis C infection polynucleotide and polypeptide sequences are used to refer to activating, inhibitory, or modulating molecules or compounds identified using in vitro and in vivo assays of polynucleotide and polypeptide sequences associated with Hepatitis C infection and/or its secondary consequences. Inhibitors are compounds that, e.g., bind to, partially or totally block activity, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity or expression of Hepatitis C infection proteins, e.g., antagonists. Antisense nucleic acids may seem to inhibit expression and subsequent function of the protein. “Activators” are compounds that increase, open, activate, facilitate, enhance activation, sensitize, agonize, or up regulate Hepatitis C infection protein activity. Inhibitors, activators, or modulators also include genetically modified versions of Hepatitis C infection proteins, e.g., versions with altered activity, as well as naturally occurring and synthetic ligands, antagonists, agonists, antibodies, small chemical molecules, and the like. Such assays for inhibitors and activators include, e.g., expressing the Hepatitis C infection protein in vitro, in cells, or cell membranes, applying putative modulator compounds, and then determining the functional effects on activity, as described above. Activators and inhibitors of Hepatitis C infection and its secondary consequences can also be identified by incubating Hepatitis C infected cells and tissues or cells and tissues secondarily affected by Hepatitis C infection with the test compound and determining increases or decreases in the expression of 1 or more Hepatitis C infection proteins, e.g., 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, or more Hepatitis C infection proteins, such as Hepatitis C infection proteins encoded by the sequences set out in Tables 1A-15.

[0099] Samples or assays comprising Hepatitis C infection proteins that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of inhibition. Control samples (untreated with inhibitors) are assigned a relative protein activity value of 100%. Inhibition of a polypeptide is achieved when the activity value relative to the control is about 80%, preferably about 50%, more preferably about 25-0%. Activation of a Hepatitis C infection polypeptide is achieved when the activity value relative to the control (untreated with activators) is about 110%, more preferably 150%, more preferably 200-500% (e.g., about two to five fold higher relative to the control), more preferably about 1000-3000% higher. However, sometimes selectivity or specificity of response in the correct organs may be significant consideration relative to absolute change.

[0100] “Antibody” refers to a polypeptide comprising a framework region from an immunoglobulin gene or fragments thereof that specifically binds and recognizes an antigen. The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes. Light chains are classified as either kappa or lambda. Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD, and IgE, respectively. Typically, the antigen-binding region of an antibody or its functional equivalent will be most critical in specificity and affinity of binding. See Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven.

[0101] An exemplary imrnunoglobulin (antibody) structural unit comprises a tetramer. Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one “light” (about 25 kD) and one “heavy” chain (about 50-70 kD). The N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids primarily responsible for antigen recognition. The terms variable light chain (VL) and variable heavy chain (VH) refer to these light and heavy chains respectively.

[0102] Antibodies exist, e.g., as intact immunoglobulins or as a number of well-characterized fragments produced by digestion with various peptidases. Thus, e.g., pepsin digests an antibody below the disulfide linkages in the hinge region to produce F(ab)′2, a dimer of Fab which itself is a light chain joined to VH-CH1 by a disulfide bond. The F(ab)′2 may be reduced under mild conditions to break the disulfide linkage in the hinge region, thereby converting the F(ab)′2 dimer into an Fab′ monomer. The Fab′ monomer is essentially Fab with part of the hinge region. See Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven. While various antibody fragments are defined in terms of the digestion of an intact antibody, it will be appreciated that such fragments may be synthesized de novo either chemically or by using recombinant DNA methodology. Thus, the term antibody, as used herein, also includes antibody fragments either produced by the modification of whole antibodies, or those synthesized de novo using recombinant DNA methodologies (e.g., single chain Fv) or those identified using phage display libraries (see, e.g., McCafferty, et al. (1990) Nature 348:552-554).

[0103] For preparation of antibodies, e.g., recombinant, monoclonal, or polyclonal antibodies, many techniques can be used. See, e.g., Kohler and Milstein (1975) Nature 256:495-497; Kozbor, et al. (1983) Immunology Today 4:72; Cole, et al. (1985) pp. 77-96 in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; Coligan (1991) Current Protocols in Immunology Lippincott; Harlow and Lane (1988) Antibodies: A Laboratory Manual CSH Press; and Goding (1986) Monoclonal Antibodies: Principles and Practice (2d ed.) Academic Press. Techniques for the production of single chain antibodies (U.S. Pat. No. 4,946,778) can be adapted to produce antibodies to polypeptides of this invention. Also, transgenic mice, or other organisms such as other mammals, may be used to express humanized antibodies. Alternatively, phage display technology can be used to identify antibodies and heteromeric Fab fragments that specifically bind to selected antigens. See, e.g., McCafferty, et al. (1990) Nature 348:552-554; Marks, et al. (1992) Biotechnology 10:779-783.

[0104] A “chimeric antibody” is an antibody molecule in which (a) the constant region, or a portion thereof, is altered, replaced or exchanged so that the antigen binding site (variable region) is linked to a constant region of a different or altered class, effector function and/or species, or an entirely different molecule which confers new properties to the chimeric antibody, e.g., an enzyme, toxin, hormone, growth factor, drug, etc.; or (b) the variable region, or a portion thereof, is altered, replaced or exchanged with a variable region having a different or altered antigen specificity.

Identification of Hepatitis C Infection-Associated Sequences

[0105] In one aspect, the expression levels of genes are determined in different patient samples for which diagnosis information is desired, to provide expression profiles. An expression profile of a particular sample is essentially a “fingerprint” of the state of the sample; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is characteristic of the state of the cell. That is, normal tissue may be distinguished from Hepatitis C infected tissue or cells or tissues and cells affected secondarily by Hepatitis C infection, by comparison with tissue or cell samples from uninfected individuals. By comparison of expression profiles derived from infected and uninfected individuals information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained.

[0106] The identification of sequences that are differentially expressed in Hepatitis C infected and non-infected individuals allows the use of this information in a number of ways. For example, a particular treatment regime may be evaluated: does a drug act to down-regulate Hepatitis C infection and/or its secondary effects, in a particular patient. Similarly, diagnosis and treatment outcomes may be done or confirmed by comparing patient samples with the known expression profiles. Furthermore, these gene expression profiles (or individual genes) allow screening of drug candidates with an eye to mimicking or altering a particular expression profile; e.g., screening can be done for drugs that suppress certain aspects of the Hepatitis C infected patient's expression profile. This may be done by making biochips comprising sets of the important Hepatitis C infection genes, which can then be used in these screens. These methods can also be done on the protein basis; that is, protein expression levels of the Hepatitis C infection proteins can be evaluated for diagnostic purposes or to screen candidate agents. In addition, the Hepatitis C infection nucleic acid sequences can be administered for gene therapy purposes, including the administration of antisense nucleic acids, or the Hepatitis C infection proteins (including antibodies and other modulators thereof) administered as therapeutic drugs.

[0107] Thus the present invention provides nucleic acid and protein sequences that are differentially expressed in Hepatitis C infected individuals, herein termed “Hepatitis C infection sequences.” Further, the invention provides means to distinguish subsets of infected individuals; e.g., those who will or will not respond to particular therapeutic treatment. As outlined below, Hepatitis C infection sequences include those that are up-regulated (e.g., expressed at a higher level) during the course of Hepatitis C infection, as well as those that are down-regulated (e.g., expressed at a lower level). In a preferred embodiment, the Hepatitis C infection sequences are from primates, e.g., humans; however, as will be appreciated by those in the art, Hepatitis C infection sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other Hepatitis C infection sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, farm animals (including sheep, goats, pigs, cows, horses, etc.), and pets (e.g., dogs, cats, etc.). Hepatitis C infection sequences from other organisms may be obtained using the techniques outlined below.

[0108] Hepatitis C infection sequences can include both nucleic acid and amino acid sequences. As will be appreciated by those in the art and is more fully outlined below, Hepatitis C infection nucleic acid sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; e.g., biochips comprising nucleic acid probes or PCR microtiter plates with selected probes to the Hepatitis C infection sequences can be generated.

[0109] A Hepatitis C infection sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the Hepatitis C infection sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.

[0110] For identifying Hepatitis C infection-associated sequences, the screen typically includes comparing the expression of genes from different tissues, but typically liver biopsy samples, of infected versus uninfected individuals. Analysis of samples from treatment responsive and treatment non-responsive patients may also be performed. Samples obtained are applied, e.g., to biochips comprising nucleic acid probes. The samples are first microdissected, if applicable, and treated as is known in the art for the preparation of mRNA. Suitable biochips are commercially available, e.g., from Affymetrix. Gene expression profiles as described herein are generated and the data analyzed. Other means for analysis may also be performed, e.g., PCR based, protein, or antibody diagnosis.

[0111] In one embodiment, the genes showing changes in expression as between normal and disease states are compared. In a preferred embodiment, those genes identified during the screen of infected individuals, that are expressed in any significant amount in uninfected individuals are removed from the profile, although in some embodiments, this is not necessary. That is, when screening for drugs, it is usually preferable that the target be disease specific, to minimize possible side effects.

[0112] In a preferred embodiment, Hepatitis C infection sequences are those that are up-regulated during Hepatitis C infection; that is, the expression of these genes is higher in the tissues of Hepatitis C infected individuals as compared to the tissues of uninfected individuals. “Up-regulation” as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being preferred. Unigene cluster identification numbers and accession numbers herein are for the GenBank sequence database and the sequences of the accession numbers are hereby expressly incorporated by reference. GenBank is known in the art, see, e.g., Benson, et al. (1998) Nuc. Acids Res. 26:1-7; and http://www.ncbi.nlm.nih.gov/. Sequences are also available in other databases, e.g., European Molecular Biology Laboratory (EMBL) and DNA Database of Japan (DDBJ). In some situations, the sequences may be derived from assembly of available sequences or be predicted from genomic DNA using exon prediction algorithms, such as FGENESH. See Salamov and Solovyev (2000) Genome Res. 10:516-522. In other situations, sequences have been derived from cloning and sequencing of isolated nucleic acids.

[0113] In another preferred embodiment, Hepatitis C infection sequences are those that are down-regulated in Hepatitis C infected individuals; that is, the expression of these genes is lower in tissue from individuals infected with Hepatitis C as compared to non-infected individuals. “Down-regulation” as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being preferred.

[0114] In other embodiments, sequences which are diagnostic, or prognostic, of response to treatment are identified. In particular, markers which are diagnostic of either response or non-response to treatment are described.

[0115] Informatics

[0116] The ability to identify genes that are over or under expressed during Hepatitis C infection or treatment can additionally provide high-resolution, high-sensitivity datasets which can be used in the areas of diagnostics, therapeutics, drug development, pharmacogenetics, protein structure, biosensor development, and other related areas. For example, the expression profiles can be used in diagnostic or prognostic evaluation of patients suffering from liver conditions, particularly Hepatitis infections. Or as another example, subcellular toxicological information can be generated to better direct drug structure and activity correlation. See Anderson (Jun. 11-12, 1998) Pharmaceutical Proteomics: Targets, Mechanism, and Function, paper presented at the IBC Proteomics conference, Coronado, Calif. Subcellular toxicological information can also be utilized in a biological sensor device to predict the likely toxicological effect of chemical exposures and likely tolerable exposure thresholds (see U.S. Pat. No. 5,811,231). Similar advantages accrue from datasets relevant to other biomolecules and bioactive agents (e.g., nucleic acids, saccharides, lipids, drugs, and the like).

[0117] Thus, in another embodiment, the present invention provides a database that includes at least one set of assay data. The data contained in the database is acquired, e.g., using array analysis either singly or in a library format. The database can be in many forms in which data can be maintained and transmitted, but is preferably an electronic database. The electronic database of the invention can be maintained on any electronic device allowing for the storage of and access to the database, such as a personal computer, but is preferably distributed on a wide area network, such as the World Wide Web.

[0118] The focus of the present section on databases that include nucleic acid, and corresponding peptide, sequence data is for clarity of illustration only. It will be apparent to those of skill in the art that similar databases can be assembled for an assay data acquired using an assay of the invention.

[0119] The compositions and methods for identifying and/or quantitating the relative and/or absolute abundance of a variety of molecular and macromolecular species from a biological sample experiencing hepatitis C infection or its secondary consequences, e.g., the identification of Hepatitis C infection-associated sequences described herein, provide an abundance of information, which can be correlated with pathological conditions, drug testing, therapeutic monitoring, gene-disease causal linkages, identification of correlates of immunity and physiological status, subsetting of patients into particular treatment responsive or non-responsive groups, among others. Although the data generated from the assays of the invention is suited for manual review and analysis, in a preferred embodiment, prior data processing using high-speed computers is utilized.

[0120] An array of methods for indexing and retrieving biomolecular information is known in the art. For example, U.S. Pat. Nos. 6,023,659 and 5,966,712 disclose a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. U.S. Pat. No. 5,953,727 discloses a relational database having sequence records containing information in a format that allows a collection of partial-length DNA sequences to be catalogued and searched according to association with one or more sequencing projects for obtaining full-length sequences from the collection of partial length sequences. U.S. Pat. No. 5,706,498 discloses a gene database retrieval system for making a retrieval of a gene sequence similar to a sequence data item in a gene database based on the degree of similarity between a key sequence and a target sequence. U.S. Pat. No. 5,538,897 discloses a method using mass spectroscopy fragmentation patterns of peptides to identify amino acid sequences in computer databases by comparison of predicted mass spectra with experimentally-derived mass spectra using a closeness-of-fit measure. U.S. Pat. No. 5,926,818 discloses a multi-dimensional database comprising a functionality for multi-dimensional data analysis described as on-line analytical processing (OLAP), which entails the consolidation of projected and actual data according to more than one consolidation path or dimension. U.S. Pat. No. 5,295,261 reports a hybrid database structure in which the fields of each database record are divided into two classes, navigational and informational data, with navigational fields stored in a hierarchical topological map which can be viewed as a tree structure or as the merger of two or more such tree structures. See also Mount (2001) Bioinformatics: Sequence and Genome Analysis CSH Press, NY; Durbin, et al. (eds. 1999) Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids Cambridge Univ. Press; Baxevanis and Oeullette (eds. 1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (2d ed.) Wiley-Liss; Rashidi and Buehler (1999) Bioinformatics: Basic Applications in Biological Science and Medicine CRC Press; Setubal, et al. (eds. 1997) Introduction to Computational Molecular Biology Brooks/Cole; Misener and Krawetz (eds. 2000) Bioinformatics: Methods and Protocols Humana Press; Higgins and Taylor (eds. 2000) Bioinformatics: Sequence, Structure, and Databanks: A Practical Approach Oxford Univ. Press; Brown (2001) Bioinformatics: A Biologist's Guide to Biocomputing and the Internet Eaton Pub.; Han and Kamber (2000) Data Mining: Concepts and Techniques Kaufmann Pub.; and Waterman (1995) Introduction to Computational Biology: Maps, Sequences, and Genomes Chap and Hall.

[0121] The present invention provides a computer database comprising a computer and software for storing in computer-retrievable form assay data records cross-tabulated, e.g., with data specifying the source of the target-containing sample from which each sequence specificity record was obtained, and perhaps patient data or response.

[0122] In an exemplary embodiment, at least one of the sources of target-containing sample is from a control tissue sample known to be free of pathological disorders. In a variation, at least one of the sources is a known pathological tissue specimen. In another variation, the assay records cross-tabulate one or more of the following parameters for each target species in a sample: (1) a unique identification code, which can include, e.g., a target molecular structure and/or characteristic separation coordinate (e.g., electrophoretic coordinates); (2) sample source; (3) absolute and/or relative quantity of the target species present in the sample; and (4) patient history or eventual treatment outcome.

[0123] The invention also provides for the storage and retrieval of a collection of target data in a computer data storage apparatus, which can include magnetic disks, optical disks, magneto-optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage arrays. Typically, the target data records are stored as a bit pattern in an array of magnetic domains on a magnetizable medium or as an array of charge states or transistor gate states, such as an array of cells in a DRAM device (e.g., each cell comprised of a transistor and a charge storage area, which may be on the transistor). In one embodiment, the invention provides such storage devices, and computer systems built therewith, comprising a bit pattern encoding a protein expression fingerprint record comprising unique identifiers for at least 10 target data records cross-tabulated with target source.

[0124] When the target is a peptide or nucleic acid, the invention preferably provides a method for identifying related peptide or nucleic acid sequences, comprising performing a computerized comparison between a peptide or nucleic acid sequence assay record stored in or retrieved from a computer storage device or database and at least one other sequence. The comparison can include a sequence analysis or comparison algorithm or computer program embodiment thereof (e.g., FASTA, TFASTA, GAP, BESTFIT) and/or the comparison may be of the relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.

[0125] The invention also preferably provides a magnetic disk, such as an IBM-compatible (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e.g., Linux, SunOS, Solaris, AIX, SCO Unix, VMS, MV, Macintosh, etc.) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay of the invention in a file format suitable for retrieval and processing in a computerized sequence analysis, comparison, or relative quantitation method.

[0126] The invention also provides a network, comprising a plurality of computing devices linked via a data link, such as an Ethernet cable (coax or 10BaseT), telephone line, ISDN line, wireless network, optical fiber, or other suitable signal transmission medium, whereby at least one network device (e.g., computer, disk array, etc.) comprises a pattern of magnetic domains (e.g., magnetic disk) and/or charge domains (e.g., an array of DRAM cells) composing a bit pattern encoding data acquired from an assay of the invention.

[0127] The invention also provides a method for transmitting assay data that includes generating an electronic signal on an electronic communications device, such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like, wherein the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method of the invention.

[0128] In a preferred embodiment, the invention provides a computer system for comparing a query target to a database containing an array of data structures, such as an assay result obtained by the method of the invention, and ranking database targets based on the degree of identity and gap weight to the target data. A central processor is preferably initialized to load and execute the computer program for alignment and/or comparison of the assay results. Data for a query target is entered into the central processor via an I/O device. Execution of the computer program results in the central processor retrieving the assay data from the data file, which comprises a binary description of an assay result.

[0129] The target data or record and the computer program can be transferred to secondary memory, which is typically random access memory (e.g., DRAM, SRAM, SGRAM, or SDRAM). Targets are ranked according to the degree of correspondence between a selected assay characteristic (e.g., binding to a selected affinity moiety) and the same characteristic of the query target and results are output via an I/O device. For example, a central processor can be a conventional computer (e.g., Intel Pentium, PowerPC, Alpha, PA-8000, SPARC, MIPS 4400, MIPS 10000, VAX, etc.); a program can be a commercial or public domain molecular biology software package (e.g., UWGCG Sequence Analysis Software, Darwin); a data file can be an optical or magnetic disk, a data server, a memory device (e.g., DRAM, SRAM, SGRAM, SDRAM, EPROM, bubble memory, flash memory, etc.); an I/O device can be a terminal comprising a video display and a keyboard, a modem, an ISDN terminal adapter, an Ethernet port, a punched card reader, a magnetic strip reader, or other suitable I/O device.

[0130] The invention also preferably provides the use of a computer system, such as that described above, which comprises: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by the methods of the invention, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values.

[0131] Characteristics of Hepatitis C Infection-Associated Proteins

[0132] Hepatitis C infection proteins of the present invention may be classified as secreted proteins, transmembrane proteins, or intracellular proteins. In one embodiment, the Hepatitis C infection protein is an intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, e.g., signaling pathways); aberrant expression of such proteins often results in unregulated or disregulated cellular processes. See, e.g., Alberts, et al. (eds. 1994) Molecular Biology of the Cell (3d ed.) Garland. For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity, and the like. Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles. In particular, many of the genes identified in the analysis of the present invention may result from virus infection or related physiology, e.g., immunological responses, etc.

[0133] An increasingly appreciated concept in characterizing proteins is the presence in the proteins of one or more motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein-protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline-rich targets. In addition, PH domains, tetratricopeptide repeats, and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers. As will be appreciated by one of ordinary skill in the art, these motifs can be identified on the basis of primary sequence; thus, an analysis of the sequence of proteins may provide insight into both the enzymatic potential of the molecule and/or molecules with which the protein may associate. One useful database is Pfam (protein families), which is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains. Versions are available via the internet from Washington University in St. Louis, the Sanger Center in England, and the Karolinska Institute in Sweden. See, e.g., Bateman, et al. (2000) Nuc. Acids Res. 28:263-266; Sonnhammer, et al. (1997) Proteins 28:405-420; Bateman, et al. (1999) Nuc. Acids Res. 27:260-262; and Sonnhammer, et al. (1998) Nuc. Acids Res. 26:320-322.

[0134] In another embodiment, the Hepatitis C infection sequences are transmembrane proteins. Transmembrane proteins are molecules that span a phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself, creates binding sites for additional SH2 domain containing proteins.

[0135] Transmembrane proteins may contain from one to many transmembrane domains. For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases, and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors such as G protein coupled receptors (GPCRs) are classified as “seven transmembrane domain” proteins, as they contain 7 membrane spanning regions. Characteristics of transmembrane domains include approximately 20 consecutive hydrophobic amino acids that may be followed by charged amino acids. Therefore, upon analysis of the amino acid sequence of a particular protein, the localization and number of transmembrane domains within the protein may be predicted (see, e.g., PSORT web site http://psort.nibb.ac.jp/). Important transmembrane protein receptors include, but are not limited to, the insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, epidermal growth factor receptor, leptin receptor, interleukin receptors, e.g., IL-1 receptor, IL-2 receptor, and other identified cytokine receptors, and chemokine receptors.

[0136] The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different extracellular motifs. Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are found on receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF, and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors, and the like. Extracellular domains also bind to cell-associated molecules. In this respect, they mediate cell-cell interactions. Cell-associated ligands can be tethered to the cell, e.g., via a glycosylphosphatidylinositol (GPI) anchor, or may themselves be transmembrane proteins. Extracellular domains also associate with the extracellular matrix and contribute to the maintenance of the cell structure.

[0137] Transmembrane proteins that are associated with Hepatitis C infection are particularly preferred in the present invention as they are readily accessible targets for immunotherapeutics, as are described herein. In addition, as outlined below, transmembrane proteins can be also useful in imaging modalities. Antibodies may be used to label such readily accessible proteins in situ. Alternatively, antibodies can also label intracellular proteins, in which case samples are typically permeablized to provide access to intracellular proteins. Diagnosis may be of biopsy samples isolated from the individual, including serum or liver samples.

[0138] It will also be appreciated by those in the art that a transmembrane protein can be made soluble by removing transmembrane sequences, e.g., through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence. Alternatively, normal or pathological processes may result in the release of membrane or intracellular proteins into the serum, e.g., by proteolytic processing to release portions of a protein into a body fluid.

[0139] In another embodiment, the Hepatitis C infection proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; often by virtue of their circulating nature, they serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor), an endocrine manner (acting on cells at a distance, e.g., secretion into the blood stream), or exocrine (secretion, e.g., through a duct or to adjacent epithelial surface as sweat glands, sebaceous glands, pancreatic ducts, lacrimal glands, mammary glands, wax producing glands of the ear, etc.). Thus secreted molecules find use in modulating or altering numerous aspects of physiology. Hepatitis C infection proteins that are secreted proteins are particularly preferred in the present invention as they serve as good therapeutic targets and also as diagnostic markers, e.g., for blood, plasma, serum, or stool tests. Diagnosis may be direct for the protein, or of a response to the protein, e.g., presence of antibodies generated to the protein. Those which are enzymes may be antibody or small molecule targets. Others may be useful as vaccine targets, e.g., via CTL mechanisms.

[0140] Use of Hepatitis C Infection Nucleic Acids

[0141] As described above, a Hepatitis C infection sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology or linkage to the Hepatitis C infection sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions. Typically, linked sequences on a mRNA are found on the same molecule.

[0142] The Hepatitis C infection nucleic acid sequences of the invention, e.g., the sequences in Tables 1A-15, can be fragments of larger genes, e.g., they are nucleic acid segments. “Genes” in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions. Accordingly, as will be appreciated by those in the art, using the sequences provided herein, extended sequences, in either direction, of the Hepatitis C infection genes can be obtained, using techniques well known in the art for cloning either longer sequences or the full length sequences; see Ausubel, et al., supra. Much can be done by informatics and many sequences can be clustered to include multiple sequences corresponding to a single gene, e.g., systems such as UniGene (see, http://www.ncbi.nlm.nih.gov/UniGene/).

[0143] Once the Hepatitis C infection nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire Hepatitis C infection nucleic acid coding regions or the entire mRNA sequence. Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant Hepatitis C infection nucleic acid can be further used as a probe to identify and isolate other Hepatitis C infection nucleic acids, e.g., extended coding regions. It can also be used as a “precursor” nucleic acid to make modified or variant Hepatitis C infection nucleic acids and proteins.

[0144] The Hepatitis C infection nucleic acids of the present invention are used in several ways. In a first embodiment, nucleic acid probes to the Hepatitis C infection nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, e.g., for gene therapy, vaccine, and/or antisense applications. Alternatively, the Hepatitis C infection nucleic acids that include coding regions of Hepatitis C infection proteins can be put into expression vectors for the expression of Hepatitis C infection proteins, again for screening purposes, for administration to a patient, to generate a vaccine, or to generate antibodies.

[0145] In a preferred embodiment, nucleic acid probes to Hepatitis C infection nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the Hepatitis C infection nucleic acids, e.g., the target sequence (either the target sequence of the sample or to other probe sequences, e.g., in sandwich assays), such that hybridization of the target sequence and the probes of the present invention occurs. As outlined below, this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids of the present invention. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by “substantially complementary” herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein. PCR technologies may also be applicable.

[0146] A nucleic acid probe is generally single stranded but can be partially single and partially double stranded. The strandedness of the probe is dictated by the structure, composition, and properties of the target sequence. In general, the nucleic acid probes range from about 8-100 bases long, with from about 10-80 bases being preferred, and from about 30-50 bases being particularly preferred. That is, generally whole genes are not used. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases.

[0147] In a preferred embodiment, more than one probe per sequence is used, with either overlapping probes or probes to different sections of the target being used. That is, two, three, four or more probes, with three being preferred, are used to build in a redundancy for a particular target. The probes can be overlapping (e.g., have some sequence in common), or separate. In some cases, PCR primers may be used to amplify signal for higher sensitivity.

[0148] Nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By “immobilized” and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and a solid support is sufficient to be Tables 1A-15 under the conditions of binding, washing, analysis, and removal as outlined below. The binding can typically be covalent or non-covalent. By “non-covalent binding” and grammatical equivalents herein is meant one or more of electrostatic, hydrophilic, and hydrophobic interactions. Included in non-covalent binding is the covalent attachment of a molecule, such as, streptavidin to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By “covalent binding” and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds, and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.

[0149] In general, the probes are attached to the biochip in a wide variety of ways, as will be appreciated by those in the art. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.

[0150] The biochip comprises a suitable solid substrate. By “substrate” or “solid support” or other grammatical equivalents herein is meant a material that can be modified to contain discrete individual sites appropriate for the attachment or association of the nucleic acid probes and is amenable to at least one detection method. As will be appreciated by those in the art, the number of possible substrates is very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene, and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, TeflonJ, etc.), polysaccharides, nylon or nitrocellulose, resins, silica or silica-based materials including silicon and modified silicon, carbon, metals, inorganic glasses, plastics, etc. In general, the substrates allow optical detection and preferably do not appreciably fluoresce. See WO 00/55627.

[0151] Generally the substrate is planar, although as will be appreciated by those in the art, other configurations of substrates may be used as well. For example, the probes may be placed on the inside surface of a tube, for flow-through sample analysis to minimize sample volume. Similarly, the substrate may be flexible, such as a flexible foam, including closed cell foams made of particular plastics.

[0152] In a preferred embodiment, the surface of the biochip and the probe may be derivatized with chemical functional groups for subsequent attachment of the two. Thus, e.g., the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups, and thiol groups, with amino groups being particularly preferred. Using these functional groups, the probes can be attached using functional groups on the probes. For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, e.g., using available linkers, homo-or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-200). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.

[0153] In this embodiment, oligonucleotides are synthesized as is known in the art, and then attached to the surface of the solid support. Either the 5′ or 3′ terminus may be attached to the solid support, or attachment may be via an internal nucleoside. In another embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.

[0154] In another embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.

[0155] Alternatively, the oligonucleotides may be synthesized on the surface, as is known in the art. For example, photoactivation techniques utilizing photopolymerization compounds and techniques are used. In a preferred embodiment, the nucleic acids can be synthesized in situ, using well known photolithographic techniques, such as those described in WO 95/25116; WO 95/35505; U.S. Pat. Nos. 5,700,637 and 5,445,934; and references cited within, all of which are expressly incorporated by reference; these methods of attachment form the basis of the Affymetrix GeneChip™ technology. Other oligonucleotide synthetic techniques may be applied.

[0156] Often, amplification-based assays are performed to measure the expression level of Hepatitis C infection-associated sequences. These assays are typically performed in conjunction with reverse transcription. In such assays, a Hepatitis C infection-associated nucleic acid sequence acts as a template in an amplification reaction (e.g., Polymerase Chain Reaction, or PCR). In a quantitative amplification, the amount of amplification product will be proportional to the amount of template in the original sample. Comparison to appropriate controls provides a measure of the amount of Hepatitis C infection-associated RNA. Methods of quantitative amplification are well known to those of skill in the art. Detailed protocols for quantitative PCR are provided, e.g., in Innis, et al. (1990) PCR Protocols: A Guide to Methods and Applications Academic Press.

[0157] In some embodiments, a TaqMan based assay is used to measure expression. TaqMan based assays use a fluorogenic oligonucleotide probe that contains a 5′ fluorescent dye and a 3′ quenching agent. The probe hybridizes to a PCR product, but cannot itself be extended due to a blocking agent at the 3′ end. When the PCR product is amplified in subsequent cycles, the 5′ nuclease activity of the polymerase, e.g., AmpliTaq, results in the cleavage of the TaqMan probe. This cleavage separates the 5′ fluorescent dye and the 3′ quenching agent, thereby resulting in an increase in fluorescence as a function of amplification (see, e.g., literature provided by Perkin-Elmer, e.g., www2.perkin-elmer.com).

[0158] Other suitable amplification methods include, but are not limited to, ligase chain reaction (LCR) (see Wu and Wallace (1989) Genomics 4:560-569, Landegren, et al. (1988) Science 241:1077-1080, and Barringer, et al. (1990) Gene 89:117-122), transcription amplification (Kwoh, et al. (1989) Proc. Nat'l Acad. Sci. USA 86:1173-1177), self-sustained sequence replication (Guatelli, et al. (1990) Proc. Nat'l Acad. Sci. USA 87:1874-1878), dot PCR, linker adapter PCR, etc.

[0159] Expression of Hepatitis C Infection Proteins from Nucleic Acids

[0160] In a preferred embodiment, Hepatitis C infection nucleic acids, e.g., encoding Hepatitis C infection proteins are used to make a variety of expression vectors to express Hepatitis C infection proteins which can then be used in screening assays, as described below. Expression vectors and recombinant DNA technology are well known (see, e.g., Ausubel, supra, and Fernandez and Hoeffler (eds. 1999) Gene Expression Systems Academic Press) and are used to express proteins. The expression vectors may be self-replicating extrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the Hepatitis C infection protein. The term “control sequences” refers to DNA sequences used for the expression of an operably linked coding sequence in a particular host organism. Control sequences that are suitable for prokaryotes, e.g., include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.

[0161] Nucleic acid is “operably linked” when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, “operably linked” means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is typically accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. Transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the Hepatitis C infection protein. Numerous types of appropriate expression vectors, and suitable regulatory sequences are known in the art for a variety of host cells.

[0162] In general, transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a preferred embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.

[0163] Promoter sequences encode either constitutive or inducible promoters. The promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known in the art, and are useful in the present invention.

[0164] In addition, an expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, e.g., in mammalian or insect cells for expression and in a prokaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are available. See, e.g., Fernandez and Hoeffler, supra; and Kitamura, et al. (1995) Proc. Nat'l Acad. Sci. USA 92:9146-9150.

[0165] In addition, in a preferred embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known in the art and will vary with the host cell used.

[0166] The Hepatitis C infection proteins of the present invention may be produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding a Hepatitis C infection protein, under the appropriate conditions to induce or cause expression of the Hepatitis C infection protein. Conditions appropriate for Hepatitis C infection protein expression will vary with the choice of the expression vector and the host cell, and will be easily ascertained by one skilled in the art through routine experimentation or optimization. For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation of the host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing of the harvest is important. For example, the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield. Alternatively, cells may be identified which naturally express relevant genes at high levels.

[0167] Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect and animal cells, including mammalian cells. Of particular interest are Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C 129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, HUVEC (human umbilical vein endothelial cells), THP1 cells (a macrophage cell line), and various other human cells and cell lines.

[0168] In a preferred embodiment, the Hepatitis C infection proteins are expressed in mammalian cells. Mammalian expression systems are also known in the art, and include retroviral and adenoviral systems. One expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048, both of which are hereby expressly incorporated by reference. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter (see, e.g., Fernandez and Hoeffler, supra). Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3′ to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenylation signals include those derived form SV40.

[0169] Methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, is well known in the art, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei.

[0170] In a preferred embodiment, Hepatitis C infection proteins are expressed in bacterial systems. Promoters from bacteriophage may also be used. In addition, synthetic promoters and hybrid promoters are also useful; e.g., the tac promoter is a hybrid of the trp and lac promoter sequences. Furthermore, a bacterial promoter can include naturally occurring promoters of non-bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable. The expression vector may also include a signal peptide sequence that provides for secretion of the Hepatitis C infection protein in bacteria. The protein is either secreted into the growth media (gram-positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed. Suitable selection genes include genes which render the bacteria resistant to drugs, e.g., ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin, and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan, and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known in the art, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others (e.g., Fernandez and Hoeffler, supra). The bacterial expression vectors are transformed into bacterial host cells using techniques such as calcium chloride treatment, electroporation, and others.

[0171] In one embodiment, Hepatitis C infection proteins are produced in insect cells, e.g., expression vectors for the transformation of insect cells, and, in particular, baculovirus-based expression vectors.

[0172] In a preferred embodiment, Hepatitis C infection protein is produced in yeast cells. Yeast expression systems include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yarrowia lipolytica.

[0173] The Hepatitis C infection protein may also be made as a fusion protein, e.g., for the creation of monoclonal antibodies, if the desired epitope is small, the Hepatitis C infection protein may be fused to a carrier protein to form an immunogen. Alternatively, the Hepatitis C infection protein may be made as a fusion protein to increase expression, or for other reasons. For example, when the Hepatitis C infection protein is a Hepatitis C infection peptide, the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes. Fusion with detection epitope tags can be made, e.g., with FLAG, His6, myc, HA, etc.

[0174] In a preferred embodiment, the Hepatitis C infection protein is purified or isolated after expression. Hepatitis C infection proteins may be isolated or purified in a variety of ways depending on what other components are present in the sample. Standard purification methods include electrophoretic, molecular, immunological, and chromatographic techniques, including ion exchange, hydrophobic, affinity, reverse-phase HPLC chromatography, affinity label, and chromatofocusing. For example, the Hepatitis C infection protein may be purified using a standard anti-Hepatitis C infection protein antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful. For general guidance in suitable purification techniques, see, e.g., Scopes (1993) Protein Purification Springer-Verlag, NY. The degree of purification necessary will vary depending on the use of the Hepatitis C infection protein. In some instances no purification will be necessary.

[0175] Once expressed and purified if necessary, the Hepatitis C infection proteins and nucleic acids are useful in a number of applications. They may be used as immunoselection reagents, as vaccine reagents, as screening agents, etc.

Variants of Hepatitis C Infection Proteins

[0176] In one embodiment, the proteins expressed as a result of Hepatitis C infection are derivative or variant proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative Hepatitis C infection peptide will often contain at least one amino acid substitution, deletion or insertion, with amino acid substitutions being particularly preferred. The amino acid substitution, insertion or deletion may occur at virtually any residue within the Hepatitis C infection peptide.

[0177] Also included within one embodiment of Hepatitis C infection proteins of the present invention are amino acid sequence variants. These variants typically fall into one or more of three classes: substitutional, insertional or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the Hepatitis C infection protein, using cassette or PCR mutagenesis or other techniques well known in the art, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant Hepatitis C infection protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis using established techniques. Amino acid sequence variants are characterized by the predetermined nature of the variation, a feature that sets them apart from naturally occurring allelic or interspecies variation of the Hepatitis C infection protein amino acid sequence. The variants typically exhibit the same qualitative biological activity as the naturally occurring analogue, although variants can also be selected which have modified characteristics as will be more fully outlined below.

[0178] While the site or region for introducing an amino acid sequence variation is generally predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed Hepatitis C infection variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, e.g., M13 primer mutagenesis and PCR mutagenesis. Screening of the mutants is done using assays of Hepatitis C infection protein activities.

[0179] Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1-20 amino acids, although considerably larger insertions may be tolerated. Deletions range from about 1-20 residues, although in some cases deletions may be much larger.

[0180] Substitutions, deletions, insertions or combinations thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration of the molecule. However, larger changes may be tolerated in certain circumstances. When small alterations in the characteristics of the Hepatitis C infection protein are desired, substitutions are generally made in accordance with the amino acid substitution relationships provided in the definition section.

[0181] The variants typically exhibit the same qualitative biological activity and will elicit the same immune response as the naturally-occurring analog, although variants also are selected to modify the characteristics of the Hepatitis C infection proteins as needed. Alternatively, the variant may be designed such that the biological activity of the Hepatitis C infection protein is altered. For example, glycosylation sites may be altered or removed.

[0182] Substantial changes in function or immunological identity are made by selecting substitutions that are less conservative than those described above. For example, substitutions may be made which more significantly affect: the structure of the polypeptide backbone in the area of the alteration, e.g., the alpha-helical or beta-sheet structure; the charge or hydrophobicity of the molecule at the target site; or the bulk of the side chain. The substitutions which in general are expected to produce the greatest changes in the polypeptide's properties are those in which (a) a hydrophilic sidechain, e.g., serine or threonine, is substituted for (or by) a hydrophobic sidechain, e.g., leucine, isoleucine, phenylalanine, valine, or alanine; (b) a cysteine or proline is substituted for (or by) another residue; (c) a residue having an electropositive side chain, e.g., lysine, arginine, or histidine, is substituted for (or by) an electronegative side chain, e.g., glutamic or aspartic acid; (d) a residue having a bulky side chain, e.g., phenylalanine, is substituted for (or by) one not having a side chain, e.g., glycine; or (e) a proline residue is incorporated or substituted, which changes the degree of rotational freedom of the peptidyl bond.

[0183] Covalent modifications of Hepatitis C infection polypeptides are included within the scope of this invention. One type of covalent modification includes reacting targeted amino acid residues of a Hepatitis C infection polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N-or C-terminal residues of a Hepatitis C infection polypeptide. Derivatization with bifunctional agents is useful, e.g., for crosslinking Hepatitis C infection polypeptides to a water-insoluble support matrix or surface for use in the method for purifying anti-Hepatitis C infection polypeptide antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e.g., 1,1-bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N-hydroxysuccinimide esters, e.g., esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3′-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-1,8-octane and agents such as methyl-3-((p-azidophenyl)dithio)propioimidate.

[0184] Other modifications include deamidation of glutaminyl and asparaginyl residues to the corresponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of serinyl, threonyl or tyrosyl residues, methylation of the amino groups of the lysine, arginine, and histidine side chains (e.g., pp. 79-86, Creighton (1992) Proteins: Structure and Molecular Properties Freeman), acetylation of the N-terminal amine, and amidation of a C-terminal carboxyl group.

[0185] Another type of covalent modification of the Hepatitis C infection polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide. “Altering the native glycosylation pattern” is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence Hepatitis C infection polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence Hepatitis C infection polypeptide. Glycosylation patterns can be altered in many ways. Different cell types may be used to express Hepatitis C infection-associated sequences to exhibit different glycosylation patterns.

[0186] Addition of glycosylation sites to Hepatitis C infection polypeptides may also be accomplished by altering the amino acid sequence thereof. The alteration may be made, e.g., by the addition of, or substitution by, one or more serine or threonine residues to the native sequence Hepatitis C infection polypeptide (for O-linked glycosylation sites). The Hepatitis C infection amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the Hepatitis C infection polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.

[0187] Another means of increasing the number of carbohydrate moieties on the Hepatitis C infection polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. See, e.g., WO 87/05330; and pp. 259-306 in Aplin and Wriston (1981) CRC Crit. Rev.

[0188] Biochem.

[0189] Removal of carbohydrate moieties present on the Hepatitis C infection polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are applicable. See, e.g., Sojar and Bahl (1987) Arch. Biochem. Biophys. 259:52-57; and Edge, et al. (1981) Anal. Biochem. 118:131-137. Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo- and exo-glycosidases. See, e.g., Thotakura, et al. (1987) Meth. Enzymol. 138:350-359.

[0190] Another type of covalent modification of Hepatitis C infection comprises linking the Hepatitis C infection polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Pat. Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192; or 4,179,337.

[0191] Hepatitis C infection polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising a Hepatitis C infection polypeptide fused to another heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of a Hepatitis C infection polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino-or carboxyl-terminus of the Hepatitis C infection polypeptide. The presence of such epitope-tagged forms of a Hepatitis C infection polypeptide can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the Hepatitis C infection polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of a Hepatitis C infection polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule, such a fusion could be to the Fe region of an IgG molecule.

[0192] Various tag polypeptides and their respective antibodies are available. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; HIS6, and metal chelation tags, the flu HA tag polypeptide and its antibody 12CA5 (Field, et al. (1988) Mol. Cell. Biol. 8:2159-2165); the c-myc tag and the 8F9, 3C7, 6E10, G4, B7, and 9E10 antibodies thereto (Evan, et al. (1985) Mol. Cell. Biol. 5:3610-3616); and the Herpes Simplex virus glycoprotein D (gD) tag and its antibody (Paborsky, et al. (1990) Protein Engineering 3:547-553). Other tag polypeptides include the Flag-peptide (Hopp, et al. (1988) BioTechnology 6:1204-1210); the KT3 epitope peptide (Martin, et al. (1992) Science 255:192-194); tubulin epitope peptide (Skinner, et al. (1991) J. Biol. Chem. 266:15163-15166); and the T7 gene 10 protein peptide tag (Lutz-Freyermuth, et al. (1990) Proc. Nat'l Acad. Sci. USA 87:6393-6397).

[0193] Also included are other Hepatitis C infection proteins of the family, and Hepatitis C infection proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related Hepatitis C infection proteins from humans or other organisms. As will be appreciated by those in the art, particularly useful probe and/or PCR primer sequences include the unique areas of the Hepatitis C infection nucleic acid sequence. As is generally known in the art, preferred PCR primers are from about 15-35 nucleotides in length, with from about 20-30 being preferred, and may contain inosine as needed. The conditions for the PCR reaction are well known. See, e.g., Innis, PCR Protocols, supra.

[0194] In addition, as is outlined herein, Hepatitis C proteins can be made that are longer than those encoded by the nucleic acids of the Tables, e.g., by the elucidation of extended sequences, the addition of epitope or purification tags, the addition of other fusion sequences, etc.

[0195] Hepatitis C proteins may also be identified as being encoded by Hepatitis C nucleic acids. Thus, Heptatitis C proteins are encoded by nucleic acids that will hybridize to the sequences of the sequence listings, or their complements, as outlined herein.

[0196] Antibodies to Hepatitis C Infection Proteins

[0197] In a preferred embodiment, when the Hepatitis C infection protein is to be used to generate antibodies, e.g., for immunotherapy or immunodiagnosis, the Hepatitis C infection protein should share at least one epitope or determinant with the full length protein. By “epitope” or “determinant” herein is typically meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller Hepatitis C infection protein will be able to bind to the full-length protein, particularly linear epitopes. In a preferred embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity.

[0198] Methods of preparing polyclonal antibodies are known to the skilled artisan (e.g., Coligan, supra; and Harlow and Lane, supra). Polyclonal antibodies can be raised in a mammal, e.g., by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include a protein encoded by a nucleic acid of the figures or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). The immunization protocol may be selected by one skilled in the art without undue experimentation.

[0199] The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein (1975) Nature 256:495-497. In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid of Tables 1A-15 or fragment thereof, or a fusion protein thereof. Generally, either peripheral blood lymphocytes (“PBLs”) are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (e.g., pp. 59-103 in Goding (1986) Monoclonal Antibodies: Principles and Practice Academic Press). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine, primate, and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells.

[0200] In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens or that have binding specificities for two epitopes on the same antigen. In one embodiment, one of the binding specificities is for a protein encoded by a nucleic acid Tables 1A-15 or a fragment thereof, the other one is for another antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific. Alternatively, tetramer-type technology may create multivalent reagents.

[0201] In a preferred embodiment, the antibodies to Hepatitis C infection protein are capable of reducing or eliminating a biological function of a Hepatitis C infection protein, as is described below. That is, the addition of anti-Hepatitis C infection protein antibodies (either polyclonal or preferably monoclonal or oligoclonal) to Hepatitis C infected cells or tissues or cells and tissues secondarily affected by Hepatitis C infection, may reduce or eliminate the Hepatitis C infection and/or its secondary consequences. Generally, at least about 25% decrease in activity, growth, size, or the like is preferred, with at least about 50% being particularly preferred and about 95-100% decrease being especially preferred.

[0202] In a preferred embodiment the antibodies to the Hepatitis C infection proteins are humanized antibodies (e.g., Xenerex Biosciences, Medarex, Inc., Abgenix, Inc., Protein Design Labs, Inc.). Humanized forms of non-human (e.g., murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains, or fragments thereof (such as Fv, Fab, Fab′, F(ab′)2 or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity and capacity. In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework (FR) regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will typically comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones, et al. (1986) Nature 321:522-525; Riechmann, et al. (1988) Nature 332:323-329; and Presta (1992) Curr. Op. Struct. Biol. 2:593-596). Humanization can be essentially performed following the method of Winter and co-workers (Jones, et al. (1986) Nature 321:522-525; Riechmann, et al. (1988) Nature 332:323-327; Verhoeyen, et al. (1988) Science 239:1534-1536), by substituting rodent CDRs or CDR sequences for corresponding sequences of a human antibody. Accordingly, such humanized antibodies are chimeric antibodies (U.S. Pat. No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by corresponding sequence from a non-human species.

[0203] Human-like antibodies can also be produced using phage display libraries (Hoogenboom and Winter (1992) J. Mol. Biol. 227:381-388; Marks, et al. (1991) J. Mol. Biol. 222:581-597) or human monoclonal antibodies (e.g., p. 77, Cole, et al. in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; and Boemer, et al. (1991) J. Immunol. 147:86-95). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in nearly all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, e.g., in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in the following scientific publications: Marks, et al. (1992) Bio/Technology 10:779-783; Lonberg, et al. (1994) Nature 368:856-859; Morrison (1994) Nature 368:812-13; Fishwild, et al. (1996) Nature Biotechnology 14:845-851; Neuberger (1996) Nature Biotechnology 14:826; and Lonberg and Huszar (1995) Intern. Rev. Immunol. 13:65-93.

[0204] By immunotherapy is meant treatment of Hepatitis C infection and its secondary consequences with an antibody raised against Hepatitis C infection proteins. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. As appreciated by one of ordinary skill in the art, the antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression of the antigen, leading to an immune response.

[0205] In a preferred embodiment the Hepatitis C infection proteins against which antibodies are raised are secreted proteins as described above. Without being bound by theory, antibodies used for treatment will typically bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted Hepatitis C infection protein, e.g., in autocrine signaling.

[0206] In another preferred embodiment, the Hepatitis C infection protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment may bind the extracellular domain of the Hepatitis C infection protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down-regulation of the transmembrane Hepatitis C infection protein. As will be appreciated by one of ordinary skill in the art, the antibody may be a competitive, non-competitive or uncompetitive inhibitor of protein binding to the extracellular domain of the Hepatitis C infection protein. The antibody is also an antagonist of the Hepatitis C infection protein. Further, the antibody prevents activation of the transmembrane Hepatitis C infection protein. The antibody may also be used to target or sensitize the cell to cytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1, INF-γ and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like. In some instances the antibody belongs to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity or antigen-dependent cytotoxicity (ADCC). Thus, Hepatitis C infection and its secondary consequences is treated by administering to a patient antibodies directed against the transmembrane Hepatitis C infection protein. Antibody-labeling may activate a co-toxin, localize a toxin payload, or otherwise provide means to locally ablate cells.

[0207] In another preferred embodiment, the antibody is conjugated to an effector moiety. The effector moiety can be a labeling moiety, e.g., a radioactive or fluorescent label, or a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity of the Hepatitis C infection protein. In another aspect the therapeutic moiety modulates the activity of molecules associated with or in close proximity to the Hepatitis C infection protein. The therapeutic moiety may inhibit enzymatic activity such as protease or collagenase or protein kinase activity associated with Hepatitis C infection and its secondary consequences. The effector may activate an endogenous physiological or immunological response.

[0208] In a preferred embodiment, the therapeutic moiety can also be a cytotoxic agent. In this method, targeting the cytotoxic agent to tissue or cells that are either directly infected with Hepatitis C or which are affected secondarily by the Hepatitis C infection, results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with Hepatitis C infection and its secondary consequences. Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their corresponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, saporin, maytansins, aurostatin, phenomycin, enomycin, and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against Hepatitis C infection proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane Hepatitis C infection proteins not only serves to increase the local concentration of therapeutic moiety in the afflicted area, but also serves to reduce deleterious side effects that may be associated with the therapeutic moiety.

[0209] In another preferred embodiment, the Hepatitis C infection protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein which facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the Hepatitis C infection protein can be targeted within a cell, e.g., the nucleus, an antibody thereto contains a signal for that target localization, e.g., a nuclear localization signal.

[0210] The antibodies to Hepatitis C afflicted cells and tissues of the invention specifically bind to Hepatitis C infection proteins. By “specifically bind” herein is meant that the antibodies bind to the protein with a Kd of at least about 0.1 mM, more usually at least about 1 μM, preferably at least about 0.1 μM or better, and most preferably, 0.01 μM or better. Selectivity of binding is also important.

[0211] Detection of Hepatitis C Infection Sequences for Diagnostic and Therapeutic Applications

[0212] In one aspect, the RNA expression levels of genes are determined for different cellular states in the Hepatitis C infection phenotype. Expression levels of genes in tissue from uninfected individuals and in Hepatitis C infected or affected tissue are evaluated to provide expression profiles. An expression profile of a particular cell state or point of development is essentially a “fingerprint” of the state. While two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is reflective of the state of the cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be performed or confirmed to determine whether a tissue sample has the gene expression profile of normal or cancerous tissue. This will provide for molecular diagnosis of related conditions.

[0213] “Differential expression,” or grammatical equivalents as used herein, refers to qualitative or quantitative differences in the temporal and/or cellular gene expression patterns within and among cells and tissue. Thus, a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, e.g., normal versus Hepatitis C infected tissue. Genes may be turned on or turned off in a particular state, relative to another state thus permitting comparison of two or more states. A qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques. Some genes will be expressed in one state or cell type, but not in both. Alternatively, the difference in expression may be quantitative, e.g., in that expression is increased or decreased; e.g., gene expression is either upregulated, resulting in an increased amount of transcript, or downregulated, resulting in a decreased amount of transcript. The degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChip™ expression arrays. See, Lockhart (1996) Nature Biotechnology 14:1675-1680. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, northern analysis, and RNase protection. As outlined above, preferably the change in expression (e.g., upregulation or downregulation) is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably at least about 200%, with from 300 to at least 1000% being especially preferred.

[0214] Evaluation may be at the gene transcript, or the protein level. The amount of gene expression may be monitored using nucleic acid probes to the DNA or RNA equivalent of the gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, e.g., with antibodies to the Hepatitis C infection protein and standard immunoassays (ELISAs, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc. Proteins corresponding to Hepatitis C infection genes, e.g., those identified as being important in a Hepatitis C infection phenotype, can be evaluated in a diagnostic test for Hepatitis C infection and/or its secondary consequences, and certainly subsetting into responsive or non-responsive to specific treatment. In a preferred embodiment, gene expression monitoring is performed simultaneously on a number of genes. Multiple protein expression monitoring can be performed as well. Similarly, these assays may be performed on an individual basis as well.

[0215] In this embodiment, the Hepatitis C infection nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of Hepatitis C infection sequences in a particular cell. The assays are further described below in the example. PCR techniques can be used to provide greater sensitivity.

[0216] In a preferred embodiment nucleic acids encoding the Hepatitis C infection protein are detected. Although DNA or RNA encoding the Hepatitis C infection protein may be detected, of particular interest are methods wherein an mRNA encoding a Hepatitis C infection protein is detected. Probes to detect mRNA can be a nucleotide/deoxynucleotide probe that is complementary to and hybridizes with the mRNA and includes, but is not limited to, oligonucleotides, cDNA or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove non-specifically bound probe, the label is detected. In another method detection of the mRNA is performed in situ. In this method permeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with target mRNA. Following washing to remove the non-specifically bound probe, the label is detected. For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding a Hepatitis C infection protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.

[0217] In a preferred embodiment, various proteins from the three classes of proteins as described herein (secreted, transmembrane or intracellular proteins) are used in diagnostic assays. The Hepatitis C infection proteins, antibodies, nucleic acids, modified proteins, and cells containing Hepatitis C infection sequences are used in diagnostic assays. This can be performed on an individual gene or corresponding polypeptide level. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes and/or corresponding polypeptides.

[0218] As described and defined herein, Hepatitis C infection proteins, including intracellular, transmembrane, or secreted proteins, find use as markers of Hepatitis C infection or treatment response. Detection of these proteins in putative Hepatitis C infected tissue as well as in tissues that are affected secondarily by Hepatitis C infection, allows for detection or diagnosis of Hepatitis C infection and/or its secondary consequences. In one embodiment, antibodies are used to detect Hepatitis C infection proteins. A preferred method separates proteins from a sample by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be another type of gel, including isoelectric focusing gels and the like). Following separation of proteins, the Hepatitis C infection protein is detected, e.g., by immunoblotting with antibodies raised against the Hepatitis C infection protein. Methods of immunoblotting are well known to those of ordinary skill in the art.

[0219] In another preferred method, antibodies to the Hepatitis C infection protein find use in in situ imaging techniques, e.g., in histology (e.g., Asai, et al. (eds. 1993) Methods in Cell Biology: Antibodies in Cell Biology (vol. 37) Academic Press). In this method cells are contacted with from one to many antibodies to the Hepatitis C infection protein(s). Following washing to remove non-specific antibody binding, the presence of the antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a detectable label. In another method the primary antibody to the Hepatitis C infection protein(s) contains a detectable label, e.g., an enzyme marker that can act on a substrate. In another preferred embodiment each of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of Hepatitis C infection proteins. Many other histological and/or imaging techniques are also provided by the invention.

[0220] In a preferred embodiment the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.

[0221] In another preferred embodiment, antibodies find use in diagnosing Hepatitis C infection from blood, urine, sputum, serum, plasma, stool, and other samples. Such samples, therefore, are useful as samples to be probed or tested for the presence of Hepatitis C infection proteins. Antibodies can be used to detect a Hepatitis C infection protein by previously described immunoassay techniques including ELISA, immunoblotting (western blotting), immunoprecipitation, BIACORE technology and the like. Alternatively, the presence of antibodies may indicate an immune response against an endogenous infection.

[0222] In a preferred embodiment, in situ hybridization of labeled Hepatitis C infection nucleic acid probes to tissue arrays is done. For example, arrays of tissue samples, including Hepatitis C infection tissue and/or normal tissue, are made. In situ hybridization (see, e.g., Ausubel, supra) is then performed. When comparing the fingerprints between an individual and a standard, the skilled artisan can make a diagnosis, a prognosis, or a prediction based on the findings. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis and molecular profiling of the condition of the cells may lead to distinctions between responsive or refractory conditions or may be predictive of outcomes.

[0223] In a preferred embodiment, the Hepatitis C infection proteins, antibodies, nucleic acids, modified proteins, and cells containing sequences associated with Hepatitis C infection and/or its secondary consequences are used in prognosis assays. As above, gene expression profiles can be generated that correlate to Hepatitis C infection and/or its secondary consequences, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being preferred. As above, Hepatitis C infection probes may be attached to biochips for the detection and quantification of Hepatitis C infection sequences in a tissue or patient. The assays proceed as outlined above for diagnosis. PCR methods may provide more sensitive and accurate quantification.

[0224] Assays for Therapeutic Compounds

[0225] In a preferred embodiment members of the proteins, nucleic acids, and antibodies as described herein are used in drug screening assays. The Hepatitis C infection proteins, antibodies, nucleic acids, modified proteins, and cells containing Hepatitis C infection sequences are used in drug screening assays or by evaluating the effect of drug candidates on a “gene expression profile” or expression profile of polypeptides. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent. See, e.g., Zlokarnik, et al. (1998) Science 279:84-88; and Heid (1996) Genome Res. 6:986-994.

[0226] In a preferred embodiment, the Hepatitis C infection proteins, antibodies, nucleic acids, modified proteins, and cells containing the native or modified Hepatitis C infection proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the Hepatitis C infection phenotype or an identified physiological function of a Hepatitis C infection protein. As above, this can be done on an individual gene level or by evaluating the effect of drug candidates on a “gene expression profile”. In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.

[0227] Having identified the differentially expressed genes herein, a variety of assays may be executed. In a preferred embodiment, assays may be run on an individual gene or protein level. That is, having identified a particular gene as up regulated during Hepatitis C infection, test compounds can be screened for the ability to modulate gene expression or for binding to the Hepatitis C infection protein. “Modulation” thus includes both an increase and a decrease in gene expression. The preferred amount of modulation will depend on the original change of the gene expression in normal versus tissue experiencing Hepatitis C infection and its secondary consequences, with changes of at least about 10%, preferably about 50%, more preferably about 100-300%, and in some embodiments about 300-1000% or greater. Thus, if a gene exhibits a 4-fold increase in tissue experiencing hepatitis C infection or its secondary consequences compared to normal tissue, a decrease of about four-fold is often desired; similarly, a 10-fold decrease in tissue experiencing Hepatitis C infection or its secondary consequences compared to normal tissue often provides a target value of a 10-fold increase in expression to be induced by the test compound.

[0228] The amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the gene product itself can be monitored, e.g., through the use of antibodies to the Hepatitis C infection protein and standard immunoassays. Proteomics and separation techniques may also allow quantification of expression.

[0229] In a preferred embodiment, gene expression or protein monitoring of a number of entities, e.g., an expression profile, is monitored simultaneously. Such profiles will typically involve a plurality of those entities described herein.

[0230] In this embodiment, the Hepatitis C infection nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of Hepatitis C infection sequences in a particular cell. Alternatively, PCR may be used. Thus, a series, e.g., of microtiter plate, may be used with dispensed primers in desired wells. A PCR reaction can then be performed and analyzed for each well.

[0231] Modulators of Testicular Cancer

[0232] Expression monitoring can be performed to identify compounds that modify the expression of one or more Hepatitis C infection-associated sequences, e.g., a polynucleotide sequence set out in Tables 1A-15. Generally, in a preferred embodiment, a test modulator is added to the cells prior to analysis. Moreover, screens are also provided to identify agents that modulate Hepatitis C infection and its secondary consequences, modulate Hepatitis C infection proteins, bind to a Hepatitis C infection protein, or interfere with the binding of a Hepatitis C infection protein and an antibody or other binding partner.

[0233] The term “test compound” or “drug candidate” or “modulator” or grammatical equivalents as used herein describes any molecule, e.g., protein, oligopeptide, small organic molecule, polysaccharide, polynucleotide, etc., to be tested for the capacity to directly or indirectly alter the Hepatitis C infection phenotype (direct or indirect) or the expression of a Hepatitis C infection sequence, e.g., a nucleic acid or protein sequence. In preferred embodiments, modulators alter expression profiles, or expression profile nucleic acids or proteins provided herein. In one embodiment, the modulator suppresses a Hepatitis C infection phenotype, e.g., to a normal tissue fingerprint. In another embodiment, a modulator induced a Hepatitis C infection phenotype. Generally, a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, e.g., at zero concentration or below the level of detection.

[0234] Drug candidates encompass numerous chemical classes, though typically they are organic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons. Preferred small molecules are less than 2000, or less than 1500 or less than 1000 or less than 500 D. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two of the functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs, or combinations thereof. Particularly preferred are peptides or orally active compounds.

[0235] In one aspect, a modulator will neutralize the effect of a Hepatitis C infection protein. By “neutralize” is meant that activity of a protein is inhibited or blocked with a consequent effect on the cell.

[0236] In certain embodiments, combinatorial libraries of potential modulators will be screened for an ability to bind to a Hepatitis C infection polypeptide or to modulate activity. Conventionally, new chemical entities with useful properties are generated by identifying a chemical compound (called a “lead compound”) with some desirable property or activity, e.g., inhibiting activity, creating variants of the lead compound, and evaluating the property and activity of those variant compounds. Often, high throughput screening (HTS) methods are employed for such an analysis.

[0237] In one preferred embodiment, high throughput screening methods involve providing a library containing a large number of potential therapeutic compounds (candidate compounds). Such “combinatorial chemical libraries” are then screened in one or more assays to identify those library members (particular chemical species or subclasses) that display a desired characteristic activity. The compounds thus identified can serve as conventional “lead compounds” or can themselves be used as potential or actual therapeutics.

[0238] A combinatorial chemical library is a collection of diverse chemical compounds generated by either chemical synthesis or biological synthesis by combining a number of chemical “building blocks” such as reagents. For example, a linear combinatorial chemical library, such as a polypeptide (e.g., mutein) library, is formed by combining a set of chemical building blocks called amino acids in every possible way for a given compound length (e.g., the number of amino acids in a polypeptide compound). Millions of chemical compounds can be synthesized through such combinatorial mixing of chemical building blocks. See Gallop, et al. (1994) J. Med. Chem. 37:1233-1251.

[0239] Preparation and screening of combinatorial chemical libraries is well known. Such combinatorial chemical libraries include, but are not limited to, peptide libraries (see, e.g., U.S. Pat. No. 5,010,175, Furka (1991) Pept. Prot. Res. 37:487-493, Houghton, et al. (1991) Nature 354:84-88), peptoids (PCT Publication No WO 91/19735), encoded peptides (PCT Publication WO 93/20242), random bio-oligomers (PCT Publication WO 92/00091), benzodiazepines (U.S. Pat. No. 5,288,514), diversomers such as hydantoins, benzodiazepines and dipeptides (Hobbs, et al. (1993) Proc. Nat'l Acad. Sci. USA 90:6909-6913, vinylogous polypeptides (Hagihara, et al. (1992) J. Amer. Chem. Soc. 114:6568-xxx), nonpeptidal peptidomimetics with a Beta-D-Glucose scaffolding (Hirschmann, et al. (1992) J. Amer. Chem. Soc. 114:9217-9218), analogous organic syntheses of small compound libraries (Chen, et al. (1994) J. Amer. Chem. Soc. 116:2661-xxx), oligocarbamates (Cho, et al. (1993) Science 261:1303-1305), and/or peptidyl phosphonates (Campbell, et al. (1994) J. Org. Chem. 59:658-xxx). See, generally, Gordon, et al. (1994) J. Med. Chem. 37:1385-1401, nucleic acid libraries (see, e.g., Stratagene, Corp.), peptide nucleic acid libraries (see, e.g., U.S. Pat. No. 5,539,083), antibody libraries (see, e.g., Vaughn, et al. (1996) Nature Biotechnology 14(3):309-314, and PCT/US96/10287), carbohydrate libraries (see, e.g., Liang, et al. (1996) Science 274:1520-1522, and U.S. Pat. No. 5,593,853), and small organic molecule libraries (see, e.g., benzodiazepines, page 33 Baum (Jan. 18, 1993) C&ENews; isoprenoids, U.S. Pat. No. 5,569,588; thiazolidinones and metathiazanones, U.S. Pat. No. 5,549,974; pyrrolidines, U.S. Pat. Nos. 5,525,735 and 5,519,134; morpholino compounds, U.S. Pat. No. 5,506,337; benzodiazepines, U.S. Pat. No. 5,288,514; and the like).

[0240] Devices for the preparation of combinatorial libraries are commercially available (see, e.g., 357 MPS, 390 MPS, Advanced Chem Tech, Louisville Ky., Symphony, Rainin, Woburn, Mass., 433A Applied Biosystems, Foster City, Calif., 9050 Plus, Millipore, Bedford, Mass.).

[0241] A number of well known robotic systems have also been developed for solution phase chemistries. These systems include automated workstations like the automated synthesis apparatus developed by Takeda Chemical Industries, LTD. (Osaka, Japan) and many robotic systems utilizing robotic arms (Zymate II, Zymark Corporation, Hopkinton, Mass.; Orca, Hewlett-Packard, Palo Alto, Calif.), which mimic the manual synthetic operations performed by a chemist. The above devices are suitable for use with the present invention. The nature and implementation of modifications to these devices (if any) so that they can operate as discussed herein will be apparent to persons skilled in the relevant art. In addition, numerous combinatorial libraries are themselves commercially available. See, e.g., ComGenex, Princeton, N.J.; Asinex, Moscow, Ru; Tripos, Inc., St. Louis, Mo.; ChemStar, Ltd, Moscow, RU; 3D Pharmaceuticals, Exton, Pa.; Martek Biosciences, Columbia, Md.; etc.

[0242] Assays to identify modulators are amenable to high throughput screening. Preferred assays thus detect enhancement or inhibition of Hepatitis C infection gene transcription, inhibition or enhancement of polypeptide expression, and inhibition or enhancement of polypeptide activity.

[0243] High throughput assays for the presence, absence, quantification, or other properties of particular nucleic acids or protein products are well known to those of skill in the art. Similarly, binding assays and reporter gene assays are similarly well known. Thus, e.g., U.S. Pat. No. 5,559,410 discloses high throughput screening methods for proteins, U.S. Pat. No. 5,585,639 discloses high throughput screening methods for nucleic acid binding (e.g., in arrays), while U.S. Pat. Nos. 5,576,220 and 5,541,061 disclose high throughput methods of screening for ligand/antibody binding.

[0244] In addition, high throughput screening systems are commercially available (see, e.g., Zymark Corp., Hopkinton, Mass.; Air Technical Industries, Mentor, Ohio; Beckman Instruments, Inc., Fullerton, Calif.; Precision Systems, Inc., Natick, Mass., etc.). These systems typically automate entire procedures, including sample and reagent pipetting, liquid dispensing, timed incubations, and final readings of the microplate in detector(s) appropriate for the assay. These configurable systems provide high throughput and rapid start up as well as a high degree of flexibility and customization. The manufacturers of such systems provide detailed protocols for various high throughput systems. Thus, e.g., Zymark Corp. provides technical bulletins describing screening systems for detecting the modulation of gene transcription, ligand binding, and the like.

[0245] In one embodiment, modulators are proteins, often naturally occurring proteins or fragments of naturally occurring proteins. Thus, e.g., cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of proteins may be made for screening in the methods of the invention. Particularly preferred in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being preferred, and human proteins being especially preferred. Particularly useful test compound will be directed to the class of proteins to which the target belongs, e.g., substrates for enzymes or ligands and receptors.

[0246] In a preferred embodiment, modulators are peptides of from about 5-30 amino acids, with from about 5-20 amino acids being preferred, and from about 7-15 being particularly preferred. The peptides may be digests of naturally occurring proteins as is outlined above, random peptides, or “biased” random peptides. By “randomized” or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may incorporate nucleotide or amino acid variations. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of the possible combinations over the length of the sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.

[0247] In one embodiment, the library is randomized, with few or no sequence preferences or constants at any position. In a preferred embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. For example, in a preferred embodiment, the nucleotides or amino acid residues are randomized within a defined class, e.g., of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines, or histidines for phosphorylation sites, etc., or to purines, etc.

[0248] Modulators of Hepatitis C infection and its secondary consequences can also be nucleic acids, as defined above.

[0249] As described above generally for proteins, nucleic acid modulating agents may be naturally occurring nucleic acids, random nucleic acids, or “biased” random nucleic acids. For example, digests of prokaryotic or eukaryotic genomes may be used as is outlined above for proteins.

[0250] In a preferred embodiment, the candidate compounds are organic chemical moieties, a wide variety of which are available in the literature.

[0251] After a candidate agent has been added and the cells allowed to incubate for some period of time, the sample containing a target sequence to be analyzed is added to the biochip. If required, the target sequence is prepared using known techniques. For example, the sample may be treated to lyse the cells, using known lysis buffers, electroporation, etc., with purification and/or amplification such as PCR performed as appropriate. For example, an in vitro transcription with labels covalently attached to the nucleotides is performed. Generally, the nucleic acids are labeled with biotin-FITC or PE, or with cy3 or cy5.

[0252] In a preferred embodiment, the target sequence is labeled with, e.g., a fluorescent, a chemiluminescent, a chemical, or a radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe. The label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected. Alternatively, the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme. The label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin. For the example of biotin, the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. Unbound labeled streptavidin is typically removed prior to analysis.

[0253] These assays can be direct hybridization assays or can comprise “sandwich assays”, which include the use of multiple probes, as is generally outlined in U.S. Pat. Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584, 5,571,670, 5,580,731, 5,571,670, 5,591,584, 5,624,802, 5,635,352, 5,594,118, 5,359,100, 5,124,246 and 5,681,697, all of which are hereby incorporated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex.

[0254] A variety of hybridization conditions may be used in the present invention, including high, moderate, and low stringency conditions as outlined above. The assays are generally run under stringency conditions which allows formation of the label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration pH, organic solvent concentration, etc.

[0255] These parameters may also be used to control non-specific binding, as is generally outlined in U.S. Pat. No. 5,681,697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.

[0256] The reactions outlined herein may be accomplished in many ways. Components of the reaction may be added simultaneously, or sequentially, in different orders, with preferred embodiments outlined below. In addition, the reaction may include a variety of other reagents. These include salts, buffers, neutral proteins, e.g., albumin, detergents, etc., which may be used to facilitate optimal hybridization and detection, and/or reduce non-specific or background interactions. Reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may also be used as appropriate, depending on the sample preparation methods and purity of the target.

[0257] The assay data are analyzed to determine the expression levels, and changes in expression levels as between states, of individual genes, forming a gene expression profile.

[0258] Screens are performed to identify modulators of the Hepatitis C infection phenotype. In one embodiment, screening is performed to identify modulators that can induce or suppress a particular expression profile, thus preferably generating the associated phenotype. In another embodiment, e.g., for diagnostic applications, having identified differentially expressed genes important in a particular state, screens can be performed to identify modulators that alter expression of individual genes. In an another embodiment, screening is performed to identify modulators that alter a biological function of the expression product of a differentially expressed gene. Again, having identified the importance of a gene in a particular state, screens are performed to identify agents that bind and/or modulate the biological activity of the gene product.

[0259] In addition screens can be done for genes that are induced in response to a candidate agent. After identifying a modulator based upon its ability to suppress an expression pattern associated with Hepatitis C infection, leading to a normal expression pattern, or to modulate a single Hepatitis C infection gene expression profile so as to mimic the expression of the gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated tissue experiencing Hepatitis C infection or its secondary consequences reveals genes that are not expressed in normal tissue or in tissue experiencing Hepatitis C infection or its secondary consequences, but are expressed in agent treated tissue. These agent-specific sequences can be identified and used by methods described herein for Hepatitis C infection genes or proteins. In particular these sequences and the proteins they encode find use in marking or identifying agent treated cells. In addition, antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated sample of tissue experiencing Hepatitis C infection or its secondary consequences.

[0260] Thus, in one embodiment, a test compound is administered to a population of cells, that have an associated Hepatitis C infection expression profile. By “administration” or “contacting” herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (e.g., a peptide) may be put into a viral construct such as an adenoviral or retroviral construct, and added to the cell, such that expression of the peptide agent is accomplished, e.g., PCT US97/01019. Regulatable gene therapy systems can also be used.

[0261] Once the test compound has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period of time. The cells are then harvested and a new gene expression profile is generated, as outlined herein.

[0262] Thus, e.g., the tissue experiencing Hepatitis C infection or it secondary consequences may be screened for agents that modulate, e.g., induce or suppress the Hepatitis C infection phenotype. A change in at least one gene, preferably many, of the expression profile indicates that the agent has an effect on Hepatitis C infection. By defining such a signature for the Hepatitis C infection phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change.

[0263] In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as “Hepatitis C infection proteins” or a “Hepatitis C infection modulatory protein”. The Hepatitis C infection modulatory protein may be a fragment, or alternatively, be the full length protein to the fragment encoded by the nucleic acids of the Tables. Preferably, the Hepatitis C infection modulatory protein is a fragment. In a preferred embodiment, the Hepatitis C infection amino acid sequence which is used to determine sequence identity or similarity is encoded by a nucleic acid of Tables 1A-15. In another embodiment, the sequences are naturally occurring allelic variants of a protein encoded by a nucleic acid of Tables 1A-15. In another embodiment, the sequences are sequence variants as further described herein.

[0264] Preferably, the Hepatitis C infection modulatory protein is a fragment of about 14-24 amino acids long. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a preferred embodiment, the fragment has an N-terminal Cys to aid in solubility. In one embodiment, the C-terminus of the fragment is kept as a free acid and the N-terminus is a free amine to aid in coupling, e.g., to cysteine.

[0265] In one embodiment the Hepatitis C infection proteins are conjugated to an immunogenic agent as discussed herein. In one embodiment the Hepatitis C infection protein is conjugated to BSA.

[0266] Measurements of Hepatitis C infection polypeptide activity, or the Hepatitis C infection phenotype can be performed using a variety of assays. For example, the effects of the test compounds upon the function of the Hepatitis C infection polypeptides can be measured by examining parameters described above. A suitable physiological change that affects activity can be used to assess the influence of a test compound on the polypeptides of this invention. When the functional consequences are determined using intact cells or animals, one can also measure a variety of effects such as, changes in intracellular second messengers such as cGMP. In the assays of the invention, mammalian Hepatitis C infection polypeptide is typically used, e.g., mouse, preferably human.

[0267] Assays to identify compounds with modulating activity can be performed in vitro. For example, a Hepatitis C infection polypeptide is first contacted with a potential modulator and incubated for a suitable amount of time, e.g., from 0.5 to 48 hours. In one embodiment, the Hepatitis C infection polypeptide levels are determined in vitro by measuring the level of protein or mRNA. The level of protein is measured, e.g., using immunoassays such as western blotting, ELISA, and the like with an antibody that selectively binds to the Hepatitis C infection polypeptide or a fragment thereof. For measurement of mRNA, amplification, e.g., using PCR, LCR, or hybridization assays, e.g., northern hybridization, RNAse protection, or dot blotting, are preferred. The level of protein or mRNA is detected using directly or indirectly labeled detection agents, e.g., fluorescently or radioactively labeled nucleic acids, radioactively or enzymatically labeled antibodies, and the like, as described herein.

[0268] Alternatively, a reporter gene system can be devised using the Hepatitis C infection protein promoter operably linked to a reporter gene such as luciferase, green fluorescent protein, CAT, or β-gal. The reporter construct is typically transfected into a cell. After treatment with a potential modulator, the amount of reporter gene transcription, translation, or activity is measured according to standard techniques.

[0269] In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as “Hepatitis C infection proteins.” The Hepatitis C infection protein may be a fragment, or alternatively, be the full length protein to a fragment shown herein.

[0270] In one embodiment, screening for modulators of expression of specific genes is performed. Typically, the expression of only one or a few genes are evaluated. In another embodiment, screens are designed to first find compounds that bind to differentially expressed proteins. These compounds are then evaluated for the ability to modulate differentially expressed activity. Moreover, once initial candidate compounds are identified, variants can be further screened to better evaluate structure activity relationships.

[0271] In a preferred embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more differentially expressed nucleic acids are made. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the Hepatitis C infection proteins can be used in the assays.

[0272] Thus, in a preferred embodiment, the methods comprise combining a Hepatitis C infection protein and a candidate compound, and determining the binding of the compound to the Hepatitis C infection protein. Preferred embodiments utilize the human Hepatitis C infection protein, although other mammalian proteins may also be used, e.g., for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative Hepatitis C infection proteins may be used.

[0273] Generally, in a preferred embodiment of the methods herein, the Hepatitis C infection protein or the candidate agent is non-diffusably bound to an insoluble support having isolated sample receiving areas (e.g., a microtiter plate, an array, etc.). The insoluble supports may be made of any composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening. The surface of such supports may be solid or porous and of any convenient shape. Examples of suitable insoluble supports include microtiter plates, arrays, membranes, and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon, or nitrocellulose, teflon™, etc. Microtiter plates and arrays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples. The particular manner of binding of the composition is not crucial so long as it is compatible with the reagents and overall methods of the invention, maintains the activity of the composition and is nondiffusable. Preferred methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to “sticky” or ionic supports, chemical crosslinking, the synthesis of the protein or agent on the surface, etc. Following binding of the protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein, or other innocuous protein or other moiety.

[0274] In a preferred embodiment, the Hepatitis C infection protein is bound to the support, and a test compound is added to the assay. Alternatively, the candidate agent is bound to the support and the Hepatitis C infection protein is added. Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this purpose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.), and the like.

[0275] The determination of the binding of the test modulating compound to the Hepatitis C infection protein may be done in a number of ways. In a preferred embodiment, the compound is labeled, and binding determined directly, e.g., by attaching all or a portion of the Hepatitis C infection protein to a solid support, adding a labeled candidate agent (e.g., a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as appropriate.

[0276] In some embodiments, just one of the components is labeled, e.g., the proteins (or proteinaceous candidate compounds) can be labeled. Alternatively, more than one component can be labeled with different labels, e.g., 125I for the proteins and a fluorophor for the compound. Proximity reagents, e.g., quenching or energy transfer reagents are also useful.

[0277] In one embodiment, the binding of the test compound is determined by competitive binding assay. The competitor is a binding moiety known to bind to the target molecule (e.g., a Hepatitis C infection protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding between the compound and the binding moiety, with the binding moiety displacing the compound. In one embodiment, the test compound is labeled. Either the compound, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at a temperature which facilitates optimal activity, typically between 4-40° C. Incubation periods are typically optimized, e.g., to facilitate rapid high throughput screening. Typically between 0.1 and 1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding.

[0278] In a preferred embodiment, the competitor is added first, followed by the test compound. Displacement of the competitor is an indication that the test compound is binding to the Hepatitis C infection protein and thus is capable of binding to, and potentially modulating, the activity of the Hepatitis C infection protein. In this embodiment, either component can be labeled. Thus, e.g., if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the test compound is labeled, the presence of the label on the support indicates displacement.

[0279] In an alternative embodiment, the test compound is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the test compound is bound to the Hepatitis C infection protein with a higher affinity. Thus, if the test compound is labeled, the presence of the label on the support, coupled with a lack of competitor binding, may indicate that the test compound is capable of binding to the Hepatitis C infection protein.

[0280] In a preferred embodiment, the methods comprise differential screening to identify agents that are capable of modulating the activity of the Hepatitis C infection proteins. In this embodiment, the methods comprise combining a Hepatitis C infection protein and a competitor in a first sample. A second sample comprises a test compound, a Hepatitis C infection protein, and a competitor. The binding of the competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the Hepatitis C infection protein and potentially modulating its activity. That is, if the binding of the competitor is different in the second sample relative to the first sample, the agent is capable of binding to the Hepatitis C infection protein.

[0281] Alternatively, differential screening is used to identify drug candidates that bind to the native Hepatitis C infection protein, but cannot bind to modified Hepatitis C infection proteins. The structure of the Hepatitis C infection protein may be modeled, and used in rational drug design to synthesize agents that interact with that site. Drug candidates that affect the activity of a Hepatitis C infection protein are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein.

[0282] Positive controls and negative controls may be used in the assays. Preferably control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding of the agent to the protein. Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.

[0283] A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g., albumin, detergents, etc., which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in an order that provides for the requisite binding.

[0284] In a preferred embodiment, the invention provides methods for screening for a compound capable of modulating the activity of a Hepatitis C infection protein. The methods comprise adding a test compound, as defined above, to a cell comprising Hepatitis C infection proteins. Many cell types may be used. The cells may contain a recombinant nucleic acid that encodes a Hepatitis C infection protein. In a preferred embodiment, a library of candidate agents are tested on a plurality of cells. In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, e.g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (e.g., cell-cell contacts). In another example, the determinations are determined at different stages of the cell cycle process.

[0285] In this way, compounds that modulate Hepatitis C infection agents are identified.

[0286] Compounds with pharmacological activity are able to enhance or interfere with the activity of the Hepatitis C infection protein. Once identified, similar structures are evaluated to identify critical structural feature of the compound.

[0287] In one embodiment, a method of inhibiting the consequences of Hepatitis C infection is provided. The method comprises administration of an inhibitor of processes that occur as a secondary consequence of Hepatitis C infection. In a further embodiment, methods of treating cells or tissues infected with Hepatitis C are provided. The method comprises administration of a inhibitor of Hepatitis C infection.

[0288] In one embodiment, a Hepatitis C infection inhibitor is an antibody as discussed above. In another embodiment, the Hepatitis C infection inhibitor is an antisense molecule.

[0289] Polynucleotide Modulators of Hepatitis C Infection and/or its Secondary Consequences Antisense Polynucleotides

[0290] In certain embodiments, the activity of a Hepatitis C infection-associated protein is down-regulated, or entirely inhibited, by the use of antisense polynucleotide, e.g., a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic acid sequence, e.g., a Hepatitis C infection protein mRNA, or a subsequence thereof. Binding of the antisense polynucleotide to the mRNA reduces the translation and/or stability of the mRNA.

[0291] In the context of this invention, antisense polynucleotides can comprise naturally-occurring nucleotides, or synthetic species formed from naturally-occurring subunits or their close homologs. Antisense polynucleotides may also have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species which are known for use in the art. Analogs are comprehended by this invention so long as they function effectively to hybridize with the Hepatitis C infection protein mRNA. See, e.g., Isis Pharmaceuticals, Carlsbad, Calif.; Sequitor, Inc., Natick, Mass.

[0292] Such antisense polynucleotides can readily be synthesized using recombinant means, or can be synthesized in vitro. Equipment for such synthesis is sold by several vendors, including Applied Biosystems. The preparation of other oligonucleotides such as phosphorothioates and alkylated derivatives is also well known.

[0293] Antisense molecules as used herein include antisense or sense oligonucleotides. Sense oligonucleotides can, e.g., be employed to block transcription by binding to the anti-sense strand. The antisense and sense oligonucleotide comprise a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for Hepatitis C infection molecules. A preferred antisense molecule is for a Hepatitis C infection sequences in Tables 1A-15, or for a ligand or activator thereof. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14 to 30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, e.g., Stein and Cohen (1988) Cancer Res. 48:2659—2668; and van der Krol, et al. (1988) BioTechniques 6:958-976).

[0294] RNA interference is a mechanism to suppress gene expression in a sequence specific manner. See, e.g., Brumelkamp, et al. (2002) Sciencexpress (Mar. 21, 2002); Sharp (1999) Genes Dev. 13:139-141; and Cathew (2001) Curr. Op. Cell Biol. 13:244-248. In mammalian cells, short, e.g., 21 nt, double stranded small interfering RNAs (siRNA) have been shown to be effective at inducing an RNAi response. See, e.g., Elbashir, et al. (2001) Nature 411:494-498. The mechanism may be used to downregulate expression levels of identified genes, e.g., treatment of or validation of relevance to disease.

[0295] Ribozymes

[0296] In addition to antisense polynucleotides, ribozymes can be used to target and inhibit transcription of Hepatitis C infection-associated nucleotide sequences. A ribozyme is an RNA molecule that catalytically cleaves other RNA molecules. Different kinds of ribozymes have been described, including group I ribozymes, hammerhead ribozymes, hairpin ribozymes, RNase P, and axhead ribozymes. See, e.g., Castanotto, et al. (1994) Adv. in Pharmacology 25:289-317.

[0297] General features of hairpin ribozymes are described, e.g., in Hampel, et al. (1990) Nuc. Acids Res. 18:299-304; European Patent Publication No. 0 360 257; U.S. Pat. No. 5,254,678. Methods of preparation are available. See, e.g., WO 94/26877; Yu, et al. (1993) Proc. Nat'l Acad. Sci. USA 90:6340-6344; Yamada, et al. (1994) Human Gene Therapy 1:39-45; Leavitt, et al. (1995) Proc. Nat'l Acad. Sci. USA 92:699-703; Leavitt, et al. (1994) Human Gene Therapy 5:1151-120; and Yamada, et al. (1994) Virology 205: 121-126.

[0298] Polynucleotide modulators of Hepatitis C infection may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its corresponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or its conjugated version into the cell. Alternatively, a polynucleotide modulator of Hepatitis C infection may be introduced into a cell containing the target nucleic acid sequence, e.g., by formation of an polynucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment.

[0299] Thus, in one embodiment, methods of modulating Hepatitis C infection in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-Hepatitis C infection antibody that reduces or eliminates the biological activity of an endogenous Hepatitis C infection protein. Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic acid encoding a Hepatitis C infection protein. This may be accomplished in any number of ways. In a preferred embodiment, e.g., when the Hepatitis C infection sequence is down-regulated during the course of Hepatitis C infection, such state may be reversed by increasing the amount of Hepatitis C infection associated gene product in the cell. This can be accomplished, e.g., by overexpressing the endogenous Hepatitis C infection gene or administering a gene encoding the Hepatitis C infection sequence, using known gene-therapy techniques. In a preferred embodiment, the gene therapy techniques include the incorporation of the exogenous gene using enhanced homologous recombination (EHR), e.g., as described in PCT/US93/03868, hereby incorporated by reference in its entirety. Alternatively, e.g., when the Hepatitis C infection sequence is up-regulated during Hepatitis C infection, the activity of the endogenous Hepatitis C infection gene is decreased, e.g., by the administration of a Hepatitis C infection antisense nucleic acid.

[0300] In one embodiment, the Hepatitis C infection proteins of the present invention may be used to generate polyclonal and monoclonal antibodies to proteins associated with Hepatitis C infection. Similarly, the Hepatitis C infection proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify Hepatitis C infection antibodies useful for production, diagnostic, or therapeutic purposes. In a preferred embodiment, the antibodies are generated to epitopes unique to a Hepatitis C infection protein; that is, the antibodies show little or no cross-reactivity to other proteins, such as related family members. The Hepatitis C infection antibodies may be coupled to standard affinity chromatography columns and used to purify proteins associated with Hepatitis C infection. The antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the Hepatitis C infection protein.

[0301] Methods of Identifying Variant Hepatitis C Infection-Associated Sequences

[0302] Without being bound by theory, expression of various Hepatitis C infection sequences is correlated with Hepatitis C infection. Accordingly, disorders based on mutant or variant Hepatitis C infection genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant Hepatitis C infection genes, e.g., determining all or part of the sequence of at least one endogenous Hepatitis C infection genes in a cell. This may be accomplished using many sequencing techniques. In a preferred embodiment, the invention provides methods of identifying the Hepatitis C infection genotype of an individual, e.g., determining all or part of the sequence of at least one Hepatitis C infection gene of the individual. This is generally done in at least one tissue of the individual, and may include the evaluation of a number of tissues or different samples of the same tissue. The method may include comparing the sequence of the sequenced Hepatitis C infection gene to a known Hepatitis C infection gene, e.g., a wild-type gene.

[0303] The sequence of all or part of a Hepatitis C infection gene can then be compared to the sequence of a known Hepatitis C infection gene to determine if any differences exist. This can be done using, e.g., known homology programs, such as Bestfit, etc. In a preferred embodiment, the presence of a difference in the sequence between the Hepatitis C infection gene of the patient and the known Hepatitis C infection gene correlates with a disease state or a propensity for a disease state, or susceptibility to effective treatment, as outlined herein.

[0304] In a preferred embodiment, the Hepatitis C infection genes are used as probes to determine the number of copies of the Hepatitis C infection gene in the genome.

[0305] In another preferred embodiment, the Hepatitis C infection genes are used as probes to determine the chromosomal localization of the Hepatitis C infection genes. Information such as chromosomal localization finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in the Hepatitis C infection gene locus.

[0306] Administration of Pharmaceutical and Vaccine Compositions

[0307] In one embodiment, a therapeutically effective dose of a Hepatitis C infection protein or modulator thereof, is administered to a patient. By “therapeutically effective dose” herein is meant a dose that produces effects for which it is administered. The exact dose will depend on the purpose of the treatment, and will be ascertainable by one skilled in the art using known techniques. See, e.g., Ansel, et al. (1999) Pharmaceutical Dosage Forms and Drug Delivery Lippincott; Lieberman (1992) Pharmaceutical Dosage Forms (vols. 1-3) Dekker, ISBN 0824770846, 082476918X, 0824712692, 0824716981; Lloyd (1999) The Art, Science and Technology of Pharmaceutical Compounding Amer. Pharmaceut. Assn.; and Pickar (1998) Dosage Calculations Thomson. Adjustments for testicular cancer degradation, systemic versus localized delivery, and rate of new protease synthesis, as well as the age, body weight, general health, sex, diet, time of administration, drug interaction, and the severity of the condition may be necessary.

[0308] A “patient” for the purposes of the present invention includes both humans and other animals, particularly mammals. Thus the methods are applicable to both human therapy and veterinary applications. In the preferred embodiment the patient is a mammal, preferably a primate, and in the most preferred embodiment the patient is human.

[0309] The administration of the Hepatitis C infection proteins and modulators thereof of the present invention can be done in a variety of ways as discussed above, including, but not limited to, orally, subcutaneously, intravenously, intranasally, transdermally, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly. In some instances, e.g., in the treatment of wounds and inflammation, the Hepatitis C infection proteins and modulators may be directly applied as a solution or spray.

[0310] The pharmaceutical compositions of the present invention comprise a Hepatitis C infection protein in a form suitable for administration to a patient. In the preferred embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. “Pharmaceutically acceptable acid addition salt” refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise unuseable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. “Pharmaceutically acceptable base addition salts” include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts, and the like. Particularly preferred are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.

[0311] The pharmaceutical compositions may also include one or more of the following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol.

[0312] The pharmaceutical compositions can be administered in a variety of unit dosage forms depending upon the method of administration. For example, unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules and lozenges. It is recognized that Hepatitis C infection protein modulators (e.g., antibodies, antisense constructs, ribozymes, small organic molecules, etc.) when administered orally, should be protected from digestion. This is typically accomplished either by complexing the molecule(s) with a composition to render it resistant to acidic and enzymatic hydrolysis, or by packaging the molecule(s) in an appropriately resistant carrier, such as a liposome or a protection barrier. Means of protecting agents from digestion are available.

[0313] The compositions for administration will commonly comprise a Hepatitis C infection protein modulator dissolved in a pharmaceutically acceptable carrier, preferably an aqueous carrier. A variety of aqueous carriers can be used, e.g., buffered saline and the like. These solutions are sterile and generally free of undesirable matter. These compositions may be sterilized by conventional, well known sterilization techniques. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents and the like, e.g., sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate and the like. The concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight, and the like in accordance with the particular mode of administration selected and the patient's needs. See, e.g., (1980) Remington's Pharmaceutical Science (18th ed.) Mack; and Hardman and Limbird (eds. 2001) Goodman and Gilman: The Pharmacological Basis of Therapeutics (10th ed.) McGraw-Hill.

[0314] Thus, a typical pharmaceutical composition for intravenous administration would be about 0.1 to 10 mg per patient per day. Dosages from 0.1 up to about 100 mg per patient per day may be used, particularly when the drug is administered to a secluded site and not into the blood stream, such as into a body cavity or into a lumen of an organ. Substantially higher dosages are possible in topical administration. Actual methods for preparing parenterally administrable compositions will be known or apparent. See, e.g., Remington's Pharmaceutical Science and Goodman and Gilman: The Pharmacological Basis of Therapeutics, supra.

[0315] The compositions containing modulators of Hepatitis C infection proteins can be administered for therapeutic or prophylactic treatments. In therapeutic applications, compositions are administered to a patient suffering from infection in an amount sufficient to cure or at least partially arrest the disease and its complications. An amount adequate to accomplish this is defined as a “therapeutically effective dose.” Amounts effective for this use will depend upon the severity of the disease and the general state of the patient's health. Single or multiple administrations of the compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. The composition should provide a sufficient quantity of the agents of this invention to effectively treat the patient. An amount of modulator that is capable of preventing or slowing the development of disease progression in a mammal is referred to as a “prophylactically effective dose.” The particular dose required for a prophylactic treatment will depend upon the medical condition and history of the mammal, the particular strains being prevented, as well as other factors such as age, weight, gender, administration route, efficiency, etc. Such prophylactic treatments may be used, e.g., in a mammal who has previously had infection to prevent a recurrence of the infection, or in a mammal who is suspected of having a significant likelihood of developing progression. Vaccine strategies may be used, in either a DNA vaccine form, or protein vaccine.

[0316] It will be appreciated that the present Hepatitis C infection protein-modulating compounds can be administered alone or in combination with additional Hepatitis C infection modulating compounds or with other therapeutic agent, e.g., other anti-viral agents or treatments.

[0317] In numerous embodiments, one or more nucleic acids, e.g., polynucleotides comprising nucleic acid sequences set forth in Tables 1A-15, such as antisense polynucleotides or ribozymes, will be introduced into cells, in vitro or in vivo. The present invention provides methods, reagents, vectors, and cells useful for expression of Hepatitis C infection-associated polypeptides and nucleic acids using in vitro (cell-free), ex vivo or in vivo (cell or organism-based) recombinant expression systems.

[0318] The particular procedure used to introduce the nucleic acids into a host cell for expression of a protein or nucleic acid is application specific. Many procedures for introducing foreign nucleotide sequences into host cells may be used. These include the use of calcium phosphate transfection, spheroplasts, electroporation, liposomes, microinjection, plasma vectors, viral vectors and any of the other well known methods for introducing cloned genomic DNA, cDNA, synthetic DNA or other foreign genetic material into a host cell. See, e.g., Berger and Kimmel (1987) Guide to Molecular Cloning Techniques from Methods in Enzymology (vol. 152) Academic Press; Ausubel, et al. (eds. 1999 and supplements) Current Protocols Lippincott; and Sambrook, et al. (2001) Molecular Cloning: A Laboratory Manual (3d ed., Vol. 1-3) CSH Press.

[0319] In a preferred embodiment, Hepatitis C infection proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, Hepatitis C infection genes (including both the full-length sequence, partial sequences, or regulatory sequences of the Hepatitis C infection coding regions) can be administered in a gene therapy application. These Hepatitis C infection genes can include inhibitory applications, e.g., inhibitory RNA, gene therapy (e.g., for incorporation into the genome), or antisense compositions.

[0320] Hepatitis C infection polypeptides and polynucleotides can also be administered as vaccine compositions to stimulate HTL, CTL, and antibody responses. Such vaccine compositions can include, e.g., lipidated peptides (see, e.g., Vitiello, et al. (1995) J. Clin. Invest. 95:341-349), peptide compositions encapsulated in poly(DL-lactide-co-glycolide) (“PLG”) microspheres (see, e.g., Eldridge, et al. (1991) Molec. Immunol. 28:287-294; Alonso, et al. (1994) Vaccine 12:299-306; Jones, et al. (1995) Vaccine 13:675-681), peptide compositions contained in immune stimulating complexes (ISCOMS) (see, e.g., Takahashi, et al. (1990) Nature 344:873-875; Hu, et al. (1998) Clin. Exp. Immunol. 113:235-243), multiple antigen peptide systems (MAPs) (see, e.g., Tam (1988) Proc. Nat'l Acad. Sci. USA 85:5409-5413; Tam (1996) J. Immunol. Meth. 196:17-32), peptides formulated as multivalent peptides; peptides for use in ballistic delivery systems, typically crystallized peptides, viral delivery vectors (Perkus, et al., p. 379, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Chakrabarti, et al. (1986) Nature 320:535-537; Hu, et al. (1986) Nature 320:537-540; Kieny, et al. (1986) Bio/Technology 4:790-795; Top, et al. (1971) J. Infect. Dis. 124:148-154; Chanda, et al. (1990) Virology 175:535-547), particles of viral or synthetic origin (see, e.g., Kofler, et al. (1996) J. Immunol. Meth. 192:25-35; Eldridge, et al. (1993) Sem. Hematol. 30:16-24; Falo, et al. (1995) Nature Med. 1:649-653), adjuvants (Warren, et al. (1986) Ann. Rev. Immunol. 4:369-388; Gupta, et al. (1993) Vaccine 11:293-306), liposomes (Reddy, et al. (1992) J. Immunol. 148:1585-1589; Rock (1996) Immunol. Today 17:131-137), or naked or particle absorbed cDNA (Ulmer, et al. (1993) Science 259:1745-1749; Robinson, et al. (1993) Vaccine 11:957-960; Shiver, et al., p 423, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Cease and Berzofsky (1994) Ann. Rev. Immunol. 12:923-989; and Eldridge, et al. (1993) Sem. Hematol. 30:16-24). Toxin-targeted delivery technologies, also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Mass.) may also be used.

[0321] Vaccine compositions often include adjuvants. Many adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a stimulator of immune responses, such as lipid A, Bortadella pertussis or Mycobacterium tuberculosis derived proteins. Certain adjuvants are commercially available as, e.g., Freund's Incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, Mich.); Merck Adjuvant 65 (Merck and Company, Inc., Rahway, N.J.); AS-2 (SmithKline Beecham, Philadelphia, Pa.); aluminum salts such as aluminum hydroxide gel (alum) or aluminum phosphate; salts of calcium, iron or zinc; an insoluble suspension of acylated tyrosine; acylated sugars; cationically or anionically derivatized polysaccharides; polyphosphazenes; biodegradable microspheres; monophosphoryl lipid A and quil A. Cytokines, such as GM-CSF, interleukin-2, -7, -12, and other like growth factors, may also be used as adjuvants.

[0322] Vaccines can be administered as nucleic acid compositions wherein DNA or RNA encoding one or more of the polypeptides, or a fragment thereof, is administered to a patient. This approach is described, for instance, in Wolff, et al., Science 247:1465 (1990) as well as U.S. Pat. Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; WO 98/04720; and in more detail below. Examples of DNA-based delivery technologies include “naked DNA”, facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated (“gene gun”) or pressure-mediated delivery (see, e.g., U.S. Pat. No. 5,922,687).

[0323] For therapeutic or prophylactic immunization purposes, the peptides of the invention can be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, e.g., as a vector to express nucleotide sequences that encode Hepatitis C infection polypeptides or polypeptide fragments. Upon introduction into a host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits an immune response. Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Pat. No. 4,722,848. Another vector is BCG (Bacille Calmette Guerin). See Stover, et al. (1991) Nature 351:456-460. A wide variety of other vectors are available for therapeutic administration or immunization, e.g., adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like. See, e.g., Shata, et al. (2000) Mol. Med. Today 6:66-71; Shedlock, et al. (2000) J. Leukoc. Biol. 68:793-806; and Hipp, et al. (2000) In Vivo 14:571-85).

[0324] Methods for the use of genes as DNA vaccines are well known, and include placing a Hepatitis C infection gene or portion of a Hepatitis C infection gene under the control of a regulatable promoter or a tissue-specific promoter for expression in a Hepatitis C infection patient. The Hepatitis C infection gene used for DNA vaccines can encode full-length Hepatitis C infection proteins, but more preferably encodes portions of the Hepatitis C infection proteins including peptides derived from the Hepatitis C infection protein. In one embodiment, a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a Hepatitis C infection gene. For example, Hepatitis C infection-associated genes or sequence encoding subfragments of a Hepatitis C infection protein are introduced into expression vectors and tested for their immunogenicity in the context of Class I MHC and an ability to generate cytotoxic T cell responses. This procedure provides for production of cytotoxic T cell responses against cells which present antigen, including intracellular epitopes.

[0325] In a preferred embodiment, the DNA vaccines include a gene encoding an adjuvant or accessory molecule with the DNA vaccine. Such adjuvant molecules may include cytokines that increase the immunogenic response to the Hepatitis C infection polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are available.

[0326] In another preferred embodiment Hepatitis C infection genes find use in generating animal models of Hepatitis C infection. When the Hepatitis C infection gene identified is repressed or diminished in cancer tissue, gene therapy technology, e.g., wherein antisense RNA directed to the Hepatitis C infection gene will also diminish or repress expression of the gene. Animal models of Hepatitis C infection find use in screening for modulators of a Hepatitis C infection-associated sequence or modulators of Hepatitis C infection. Similarly, transgenic animal technology including gene knockout technology, e.g., as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence or increased expression of the Hepatitis C infection protein. When desired, tissue-specific expression or knockout of the Hepatitis C infection protein may be necessary.

[0327] It is also possible that the Hepatitis C infection protein is overexpressed during Hepatitis C infection. As such, transgenic animals can be generated that overexpress the Hepatitis C infection protein. Depending on the desired expression level, promoters of various strengths can be employed to express the transgene. Also, the number of copies of the integrated transgene can be determined and compared for a determination of the expression level of the transgene. Animals generated by such methods find use as animal models of Hepatitis C infection and are additionally useful in screening for modulators to treat Hepatitis C infection and/or its secondary consequences.

[0328] Kits for Use in Diagnostic and/or Prognostic Applications

[0329] For use in diagnostic, research, and therapeutic applications suggested above, kits are also provided by the invention. In the diagnostic and research applications such kits may include some of the following: assay reagents, buffers, Hepatitis C infection-specific nucleic acids or antibodies, hybridization probes and/or primers, antisense polynucleotides, ribozymes, dominant negative Hepatitis C infection polypeptides or polynucleotides, small molecules inhibitors of Hepatitis C infection-associated sequences etc. A therapeutic product may include sterile saline or another pharmaceutically acceptable emulsion and suspension base.

[0330] In addition, the kits may include instructional materials containing directions (e.g., protocols) for the practice of the methods of this invention. While the instructional materials typically comprise written or printed materials they are not limited to such. Any medium capable of storing such instructions and communicating them to an end user is contemplated by this invention. Such media include, but are not limited to electronic storage media (e.g., magnetic discs, tapes, cartridges, chips), optical media (e.g., CD ROM), and the like. Such media may include addresses to internet sites that provide such instructional materials.

[0331] The present invention also provides for kits for screening for modulators of Hepatitis C infection-associated sequences. Such kits can be prepared from readily available materials and reagents. For example, such kits can comprise one or more of the following materials: a Hepatitis C infection-associated polypeptide or polynucleotide, reaction tubes, and instructions for testing Hepatitis C infection-associated activity. Optionally, the kit contains biologically active Hepatitis C infection protein. A wide variety of kits and components can be prepared according to the present invention, depending upon the intended user of the kit and the particular needs of the user. Diagnosis would typically involve evaluation of a plurality of genes or products. The genes will be selected based on correlations with important parameters in disease which may be identified in historical or outcome data.

[0332] It is understood that the examples described above in no way serve to limit the true scope of this invention, but rather are presented for illustrative purposes. All publications, sequences of accession numbers, and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.

EXAMPLES

Example 1

Gene Chip Analyses

[0333] Molecular profiles of various normal and testicular cancer tissues were determined and analyzed using gene chips. RNA was isolated and gene chip analysis was performed as described (Glynne, et al. (2000) Nature 403:672-676; Zhao, et al. (2000) Genes Dev. 14:981-993).

[0334] Tables 1B-14B list the accession numbers for those Pkey's lacking UnigeneID's for tables 1A-14A. For each probeset is listed the gene cluster number from which nucleotides were designed. Gene clusters were compiled using sequences derived from Genbank ESTs and mRNAs. These sequences were clustered based on sequence similarity using Clustering and Alignment Tools (DoubleTwist, Oakland Calif.). Genbank accession numbers for sequences comprising each cluster are listed in the “Accession” column.

[0335] Tables 1C-14C list genomic positioning for Pkeys lacking Unigene ID's and accession numbers in tables 1A-14A. For each predicted exon is listed genomic sequence source used for prediction. Nucleotide locations of each predicted exon are also listed.

TABLE 1A
589 GENES UPREGULATED IN HEPATITIS C [see 60/308, 188]
Pkey	ExAccn	UnigeneID	Title	R1
428227	AA321649	Hs. 2248	INTERFERON-GAMMA INDUCED PROTEIN PRECURSOR (G	32
426711	AA383471	Hs. 180669	conserved gene amplified in osteosarcoma	20
408063	BE086548	Hs. 42346	calcineurin-binding protein calsarcin-1	19
422746	NM_004484	Hs. 119651	glypican 3	18
418318	U47732	Hs. 84072	transmembrane 4 superfamily member 3	11
414052	AW578849	Hs. 283552	ESTs, Weakly similar to unnamed protein produ	11
453319	AI985369	Hs. 20117	ESTs	10
424878	H57111	Hs. 221132	ESTs	10
426793	X89887	Hs. 172350	HIR (histone cell cycle regulation defective,	10
434210	AA665612	Hs. 120874	ESTs	9
449613	N63808	Hs. 34299	ESTs	8
421904	BE143533	Hs. 109309	hypothetical protein FLJ20035	8
427283	AL119796	Hs. 174185	ectonucleotide pyrophosphatase/phosphodiester	8
416206	AW206248	Hs. 111092	Homo sapiens cDNA: FLJ22332 fis, clone HRC057	8
408096	BE250162	Hs. 83765	dihydrofolate reductase	8
447541	AK000288	Hs. 18800	hypothetical protein FLJ20281	8
414812	X72755	Hs. 77367	monokine induced by gamma interferon	8
436169	AA888311	Hs. 17602	Homo sapiens cDNA FLJ12381 fis, clone MAMMA10	7
409231	AA446644	Hs. 692	GA733-2; epithelial glycoprotein (EGP) (KSA)	7
418216	AA662240	Hs. 283099	AF15q14 protein	7
432094	AI658580	Hs. 61426	ESTs	7
425053	AF046024	Hs. 154320	ubiquitin-activating enzyme E1C (homologous t	7
417621	AV654694	Hs. 82316	interferon-induced, hepatitis C-associated mi	7
414004	AA737033	Hs. 7155	ESTs, Weakly similar to 2115357A TYKi protein	7
426052	N49068	Hs. 93966	ESTs	7
435102	AW899053	Hs. 76917	F-box only protein 8	7
417788	AI436699	Hs. 84928	nuclear transcription factor Y, beta	7
445757	AW449065	Hs. 13264	KIAA0856 protein	7
456619	AV647917	Hs. 107153	inhibitor of growth family, member 1-like	7
419743	AW408762	Hs. 127478	ESTs	7
414737	AI160386	Hs. 125087	ESTs	7
428708	NM_014897	Hs. 190386	KIAA0924 protein	7
449718	AA459480	Hs23956	hypothetical protein FLJ20502	6
448402	BE244226	Hs. 21094	RAB18, member RAS oncogene family	6
434733	AI334367	Hs. 159337	ESTs	6
425266	J00077	Hs. 155421	alpha-fetoprotein	6
432706	NM_013230	Hs. 286124	CD24	6
407204	R41933	Hs. 140237	ESTs, Weakly similar to AF119917 13 PRO1722 [	6
409401	AI201895	Hs. 181309	proteasome (prosome, macropain) subunit, alph	6
424626	AA344308	Hs. 128427	ESTs	6
443547	AW271273	Hs. 23767	ESTs	6
409068	AW236991	Hs. 102495	ESTs	6
422173	BE385828	Hs. 250619	phorbolin-like protein MDS019	6
425815	R94023	Hs. 94560	ESTs	6
448111	AA053486	Hs. 20315	interferon-induced protein with tetratricopep	6
430594	AK000790	Hs. 246885	hypothetical protein FLJ20783	6
432435	BE218886	Hs. 282070	ESTs	6
449245	AI636539	Hs. 224296	ESTs	6
400719	NM_004055	Hs. 6133	calpain 5	6
442961	BE614474	Hs. 289074	Homo sapiens cDNA FLJ13986 fis, clone Y79AA10	6
409153	W03754	Hs. 50813	hypothetical protein FLJ20022	6
422553	AI697720	Hs. 171455	ESTs	6
442432	BE093589	Hs. 38178	Homo sapiens cDNA: FLJ23468 fis, clone HSI116	6
437086	AW291411	Hs. 192531	ESTs, Weakly similar to AF244088 1 zinc finge	6
401598	AA172106	Hs. 110950	Rag C protein	6
438523	H66220	Hs. 278177	ESTs	6
437267	AW511443	Hs. 258110	ESTs	6
408035	NM_006242	Hs. 42215	protein phosphatase 1, regulatory subunit 6	5
433401	AF039698	Hs. 284217	serologically defined colon cancer antigen 33	5
410541	AA065003	Hs. 64179	hypothetical protein	5
455743	BE073754		gb: RC0-BT0561-210100-032-d07 BT0561 Homo sapi	5
429167	BE465867	Hs. 197751	KIAA0666 protein	5
429490	AI971131	Hs. 293684	ESTs, Weakly similar to alternatively spliced	5
434263	N34895	Hs. 44648	ESTs	5
441046	W01538	Hs. 126742	ESTs	5
452327	AK000196	Hs. 29052	hypothetical protein FLJ20189	5
416504	T85831	Hs. 16004	ESTs	5
432723	D29677	Hs. 3085	KIAA0054 gene product; Helicase	5
423588	W18186	Hs. 117688	ESTs, Weakly similar to ALU5_HUMAN ALU SUBFAM
432960	AW150945	Hs. 144758	ESTs	5
403041	c21p3_565	predicted exon
433001	AF217513	Hs. 279905	clone HQ0310 PRO0310p1	5
419407	AW410377	Hs. 41502	Homo sapiens cDNA: FLJ21276 fis, clone COL018	5
411252	AB018549	Hs. 69328	MD-2 protein	5
444670	H58373	Hs. 37494	ESTs	5
445525	BE149866	Hs. 14831	ESTs	5
414646	AA353776	Hs. 901	CD48 antigen (B-cell membrane protein)	5
429747	M87507	Hs. 2490	caspase 1, apoptosis-related cysteine proteus	5
434666	AF151103	Hs. 112259	T cell receptor gamma locus	5
413541	BE147036		gb: QV4-HT0222-091199-024-e10 HT0222 Homo sapi	5
424737	BE301883	Hs. 152707	glioblastoma amplified sequence	5
426780	BE242284	Hs. 172199	adenylate cyclase 7	5
441562	AW578981	Hs. 52184	hypothetical protein FLJ20618	5
446459	AI680731	Hs. 170399	ESTs	5
409342	AU077058	Hs. 54089	BRCA1 associated RING domain 1	5
410577	X91911	Hs. 64639	glioma pathogenesis-related protein	5
428250	AW809208	Hs. 183297	DKFZP566F2124 protein	5
450447	AF212223	Hs. 25010	hypothetical protein P15-2	5
430261	AA305127	Hs. 237225	ribosomal protein S5 pseudogene 1	5
433312	AI241331	Hs. 131765	ESTs	5
442366	AA115629	Hs. 118531	ESTs	5
427846	AW499770	Hs. 180948	KIAA0729 protein	5
454075	R43826	Hs. 16313	ESTs	5
425324	M89470	Hs. 155644	paired box gene 2	5
410527	AW851066		gb: IL3-CT0220-150200-070-B02 CT0220 Homo sapi	5
456439	AA251242	Hs. 103238	ESTs	5
434948	AI498469	Hs. 12622	ESTs, Highly similar to AF161436 1 HSPC318 [H	5
436488	BE620909	Hs. 261023	hypothetical protein FLJ20958	5
411466	AW847669		gb: IL3-CT0213-280100-056-G10 CT0213 Homo sapi	5
432378	AI493046	Hs. 146133	ESTs	5
402526	c1p1_17942	predicted exon
420433	NM_007016	Hs. 97627	protein similar to E.coli yhdg and R. capsula	5
441595	AW206035	Hs. 192123	ESTs	5
430008	AW085625	Hs. 186838	ESTs; Weakly similar to similar to zinc finge	5
434924	AA443164	Hs. 23259	hypothetical protein FLJ13433	5
419003	T78640	Hs. 268595	ESTs	5
435126	AI393666	Hs. 42315	Homo sapiens cDNA FLJ13036 fis, clone NT2RP30	5
447513	AW955776		gb: EST367846 MAGE resequences, MAGD Homo sapi	5
423258	L13460	Hs. 1644	cytochrome P450, subfamily VIIA (cholesterol	5
417308	H60720	Hs. 81892	KIAA0101 gene product	4
442760	BE075297	Hs. 10067	ESTs, Weakly similar to WASP-family protein	4
444758	AL044878	Hs. 11899	3-hydroxy-3-methylglutaryl-Coenzyme A reducta	4
448752	AA593867	Hs. 170890	Homo sapiens cDNA: FLJ21129 fis, clone CAS062	4
424623	AW963062	Hs. 165809	ESTs	4
431982	AW419296	Hs. 105754	ESTs	4
441028	AI333660	Hs. 17558	ESTs	4
402811	c1p3_2372		predicted exon	4
416839	H94900	Hs. 17882	ESTs	4
421029	AW057782	Hs. 293053	ESTs	4
417301	AI478158	Hs. 164478	hypothetical protein FLJ21939 similar to 5-az	4
430778	D90337	Hs. 247916	natriuretic peptide precursor C	4
443380	AI792478	Hs. 135377	ESTs	4
447183	AI554733	Hs. 173182	ESTs	4
456383	AI148037		gb: qg61e01.r1 Soares_testis_NHT Homo sapiens	4
458239	BE439877	Hs. 283389	ESTs	4
407190	AA600135		gb: ae50c06.s1 Stratagene lung carcinoma 93721	4
425583	AF077346	Hs. 158315	interleukin 18 receptor accessory protein	4
439593	BE073597	Hs. 124863	ESTs	4
430200	BE613337	Hs. 234896	geminin	4
456299	R93374	Hs. 14173	ESTs	4
421939	BE169531	Hs. 109727	TAK1-binding protein 2; KIAA0733 protein	4
437282	AI810593	Hs. 16587	ESTs	4
410315	AI638871	Hs. 17625	ESTs	4
408380	AF123050	Hs. 44532	diubiquitin	4
442993	BE018682	Hs. 44343	ESTs	4
450560	BE383204		gb: 601298758F1 NIH_MGC_19 Homo sapiens cDNA c	4
407444	AF229803		gb: Homo sapiens endozepine-like protein type	4
408558	AW015759	Hs. 235709	ESTs	4
431214	AA294921	Hs. 250811	v-ral simian leukemia viral oncogene homolog	4
441887	AW967865	Hs. 92145	ESTs	4
413871	W17187	Hs. 75598	heterogeneous nuclear ribonucleoprotein A2/B1	4
422363	T55979	Hs. 115474	replication factor C (activator 1) 3 (38 kD)	4
439175	AF086021	Hs. 271113	ESTs	4
419375	W27916		gb: 39f6 Humun retina cDNA randomly primed sub	4
424430	AI769467	Hs. 96769	ESTs	4
435571	AF212225	Hs. 283693	BM022 protein	4
425100	AF051850	Hs. 154567	supervillin	4
410430	AW732554		gb: bb08b10.y1 NIH_MGC_14 Homo sapiens cDNA cl	4
430273	AI311127	Hs. 125522	ESTs	4
449052	AW029507	Hs. 161102	ESTs	4
454750	AW866285		gb: QV4-SN0024-080400-167-a09 SN0024 Homo sapi	4
429732	U20158	Hs. 2488	lymphocyte cytosolic protein 2 (SH2 domain-co	4
403747	c4p1_4301		predicted exon	4
418724	AA460597	Hs. 87784	hypothetical protein dJ102H19.4	4
414899	AW975433	Hs. 36288	ESTs	4
433112	AA973801	Hs. 144553	ESTs, Weakly similar to unnamed protein produ	4
439971	W32474	Hs. 7942	hypothetical protein FLJ20080	4
421170	BE217797	Hs. 126052	ESTs	4
443454	AI057494	Hs. 133421	ESTs	4
443885	H91806	Hs. 15284	ESTs	4
446648	AL137521	Hs. 15797	Homo sapiens mRNA; cDNA DKFZp434D0218 (from c	4
456182	H85328	Hs. 239045	ESTs	4
431318	AA502700	Hs. 293147	ESTs	4
453950	AA156998	Hs. 211568	eukaryotic translation initiation factor 4 ga	4
411857	AW879403		gb: PM0-OT0019-150300-002-d01 OT0019 Homo sapi	4
409205	AI952884	Hs. 14832	ESTs, Moderately similar to unnamed protein p	4
411083	N41340	Hs. 68318	hypothetical protein FLJ20344	4
428035	AA482027	Hs. 142569	ESTs	4
435703	AW630133	Hs. 83313	GK003 protein	4
413786	AW613780	Hs. 13500	ESTs	4
434375	BE277910	Hs. 3833	3′-phosphoadenosine 5′-phosphosulfate synthas	4
448478	AI523218	Hs. 203456	ESTs	4
451192	AA019551	Hs. 60687	ESTs, Moderately similar to KIAA0544 protein	4
457235	L20433	Hs. 211588	POU domain, class 4, transcription factor 1	4
425491	AA883316	Hs. 255221	ESTs	4
430820	AF194815	Hs. 248012	immunoglobulin lambda variable 4-3	4
432572	AI660840	Hs. 191202	ESTs, Weakly similar to ALUE_HUMAN !!!! ALU C	4
457250	AA811987	Hs. 125779	ESTs	4
406367	ph2_15338		predicted exon	4
455960	BE165256		gb: QV1-HT0473-130300-106-f04 HT0473 Homo sapi	4
429503	AA394183	Hs. 26873	ESTs	4
419286	AA236005	Hs. 221303	ESTs	4
453555	N23574	Hs. 123649	ESTs, Moderately similar to ALU7_HUMAN ALU SU	4
423165	AI937547	Hs. 124915	Human DNA sequence from clone 380A1 on chromo	4
402230	c19p1_5271	predicted exon	DAL8
451356	AA748418	Hs. 164577	ESTs	4
409712	AA167385	Hs. 13583	ESTs	4
442281	N34742	Hs. 170065	Homo sapiens cDNA FLJ13492 fis, clone PLACE10	4
434941	AW073202	Hs. 18368	DKFZP564B0769 protein	4
424145	AW802763	Hs. 193124	ESTs	4
430665	BE350122	Hs. 157367	ESTs	4
442878	AI868648	Hs. 22315	ESTs	4
457307	AI311127	Hs. 125522	ESTs	4
414522	AW518944	Hs. 76325	Homo sapiens cDNA: FLJ23125 fis, clone LNG082	4
421650	AA781795	Hs. 122587	ESTs	4
426416	AW612744	Hs. 169824	killer cell lectin-like receptor subfamily B,	4
458836	AI568607	Hs. 182112	ESTs	4
424113	AI743880	Hs. 12876	ESTs	4
418549	AA927177	Hs. 86041	CGG triplet repeat binding protein 1	4
442297	NM_006202	Hs. 89901	phosphodiesterase 4A, cAMP-specific (dunce (D	4
419046	T81816	Hs. 193723	ESTs	4
429025	AI399910	Hs. 4842	ESTs	4
433230	AW136134	Hs. 220277	ESTs	4
452744	AI267652	Hs. 30504	Homo sapiens mRNA; cDNA DKFZp434E082 (from cl	4
446488	AB037782	Hs. 15119	KIAA1361 protein	4
422052	AA302744	Hs. 104518	ESTs	4
430299	W28673	Hs. 106747	serine carboxypeptidase 1 precursor protein	4
442431	BE349856		gb: ht05a12.x1 NCI_CGAP_Kid13 Homo sapiens cDN	4
411653	AF070578	Hs. 71168	Homo sapiens clone 24674 mRNA sequence	4
440384	AA884275	Hs. 137052	ESTs	4
443542	AI927065	Hs. 146040	ESTs	4
443638	AW028696	Hs. 145679	ESTs	4
431910	AK000142	Hs. 272192	Homo sapiens mRNA tor KIAA1590 protein, parti	4
440381	AA917808	Hs. 190495	ESTs	4
407272	X98958		gb: H. sapiens rearranged Ig heavy chain (clone	4
417173	U61397	Hs. 81424	ubiquitin-like 1 (sentrin)	4
417675	AI808607	Hs. 3781	similar to murine leucine-rich repeat protein	4
446552	AW470827	Hs. 156241	ESTs	4
450697	AW152166	Hs. 182113	ESTs	4
411960	R77776	Hs. 18103	ESTs	4
418637	T86737	Hs. 193536	ESTs	4
444065	AW449415	Hs. 10260	Homo sapiens cDNA FLJ11341 fis, clone PLACE10	4
409038	T97490	Hs. 50002	small inducible cytokine subfamily A (Cys-Cys	3
418205	L21715	Hs. 83760	troponin I, skeletal, fast	3
435177	AI018174	Hs. 42936	ESTs	3
436027	AI864053	Hs. 39972	ESTs, Weakly similar to I38588 reverse transc	3
452420	BE564871	Hs. 29463	centrin, EF-hand protein, 3 (CDC31 yeast homo	3
423839	AA985505	Hs. 127217	ESTs	3
435163	AA668884	Hs. 19155	ESTs	3
449704	AK000733	Hs. 23900	GTPase activating protein	3
433854	AA610649		gb: np95c03.s1 NCI_CGAP_Thy1 Homo sapiens cDNA	3
414821	M63835	Hs. 77424	Fc fragment of IgG, high affinity Ia, recepto	3
431300	AA502346		gb: ne26b03.s1 NCI_CGAP_Co3 Homo sapiens cDNA	3
407469	D55640		gb: Human monocyte PABL (pseudoautosomal bound	3
450515	AW304226	Hs. 7298	biphenyl hydrolase-like (serine hydrolase; br	3
430750	AI650360	Hs. 100256	ESTs	3
410833	AW806900		gb: QV4-ST0023-160400-172-d02 ST0023 Homo sapi	3
426062	N57014	Hs. 44013	ESTs	3
432945	AL043683	Hs. 271357	ESTs, Weakly similar to unnamed protein produ	3
455708	BE069326		gb: QV3-BT0381-170100-060-g03 BT0381 Homo sapi	3
443240	R02419	Hs. 15338	ESTs	3
451429	AA525993	Hs. 173699	ESTs, Weakly similar to ALU1_HUMAN ALU SUBFAM	3
435812	AA700439	Hs. 188490	ESTs	3
453799	N32080	Hs. 271700	ESTs	3
406970	M29994		gb: Human alpha-I spectrin gene, exon 12.	3
425195	AA352026		gb: EST59954 Infant brain Homo sapiens cDNA 5′	3
428180	AI129767	Hs. 182874	Homo sapiens cDNA: FLJ21929 fis, clone HEP042	3
430753	AI432401	Hs. 2659	fibrinogen-like 2	3
445800	AA126419	Hs. 301632	ESTs	3
439680	AW245741	Hs. 58461	ESTs, Weakly similar to Unknown gene product	3
444858	AI199738	Hs. 208275	ESTs, Weakly similar to unnamed protein produ	3
422879	AI241409	Hs. 188092	ESTs	3
444888	AI651039	Hs. 148559	ESTs	3
407897	AA812234	Hs. 270134	hypothetical protein FLJ20280	3
409512	AW979187	Hs. 293591	ESTs, Weakly similar to hypothetical protein	3
419843	AA749220	Hs. 177708	ESTs	3
436053	AI057224	Hs. 15443	ESTs	3
420968	AW968775	Hs. 259760	ESTs	3
457707	AW974642		gb: EST386746 MAGE resequences, MAGM Homo sapi	3
442679	R53718	Hs. 107882	hypothetical protein FLJ10659	3
434016	AF113698	Hs. 283774	clone FLB7343	3
450330	AW500775	Hs. 24817	hypothetical protein FLJ20136	3
454271	AW293271	Hs. 255179	ESTs	3
430382	AA477908	Hs. 282267	ESTs	3
458389	H70284	Hs. 160152	ESTs, Weakly similar to FETA_HUMAN ALPHA-FETO	3
413670	AB000115	Hs. 75470	hypothetical protein, expressed in osteoblast	3
451253	H48299	Hs. 26126	claudin 10	3
442805	AI201229	Hs. 131262	ESTs	3
436260	BE172762	Hs. 292710	ESTs, Weakly similar to ALU5_HUMAN ALU SUBFAM	3
410099	AA081630	Hs. 169387	KIAA0036 gene product	3
430552	AA176374	Hs. 243886	nuclear autoantigenic sperm protein (histone-	3
452548	AL050321	Hs. 29846	Human DNA sequence from clone 717M23 on chrom	3
418183	NM_001772	Hs. 83731	CD33 antigen (gp67)	3
457470	AB040973	Hs. 272385	G protein-coupled receptor 72	3
419135	R61448	Hs. 106728	ESTs, Weakly similar to KIAA1353 protein [H.s	3
448219	AA228092	Hs. 119569	ESTs, Weakly similar to growth factor recepto	3
413605	BE152644		gb: CM1-HT0329-250200-128-f09 HT0329 Homo sapi	3
435106	AA100847	Hs. 193380	ESTs, Highly similar to AF174600 1 F-box prot	3
410850	AW362867	Hs. 288699	Homo sapiens cDNA: FLJ21425 fis, clone COL041	3
444665	BE613126	Hs. 47783	ESTs, Weakly similar to T12540 hypothetical p	3
454000	AA040620	Hs. 109144	ESTs	3
451644	N23235	Hs. 30567	ESTs	3
445594	AW058463	Hs. 12940	zinc-fingers and homeoboxes 1	3
407696	AI697340	Hs. 76549	ATPase, Na+/K+ transporting, alpha 1 polypept	3
432606	NM_002104	Hs. 3066	granzyme K (serine protease, granzyme 3; tryp	3
435511	AA683336	Hs. 189046	ESTs	3
410324	AW292539	Hs. 30177	ESTs	3
429556	AW139399	Hs. 98988	ESTs	3
446751	AA766998	Hs. 85874	ESTs, Weakly similar to predicted using Genef	3
406038	Y14443	Hs. 88219	zinc finger protein 200	3
440621	AW296024	Hs. 150434	ESTs	3
444342	NM_014398	Hs. 10887	similar to lysosome-associated membrane glyco	3
445715	AB012958	Hs. 13137	UV radiation resistance associated gene	3
417933	X02308	Hs. 82962	thymidylate synthetase	3
430929	AA489166	Hs. 156933	ESTs	3
400617	AF151064	Hs. 36069	hypothetical protein	3
402643	c1p1_28109	predicted exon
410173	AA706017	Hs. 119944	ESTs	3
445664	AW968638	Hs. 237691	ESTs	3
437830	AB020658	Hs. 5867	KIAA0851 protein	3
404287	c6p3_5616		predicted exon	3
407366	AF026942		gb: Homo sapiens cig33 mRNA, partial sequence.	3
417771	AA804698	Hs. 82547	retinoic acid receptor responder (tazarotene	3
447645	AW897321	Hs. 159699	ESTs	3
454038	X06374	Hs. 37040	platelet-derived growth factor alpha polypept	3
442316	Z75331	Hs. 8217	Homo sapiens cDNA: FLJ23025 fis, clone LNG017	3
433586	T85301		gb: yd78d06.s1 Soares fetal liver spleen 1NFLS	3
408622	AA056060	Hs. 202577	EST cluster (not in UniGene)	3
428249	AA130914	Hs. 183291	zinc finger protein 268	3
448019	AW947164	Hs. 195641	ESTs	3
417228	AL134324	Hs. 7312	ESTs	3
430219	X99209	Hs. 235887	HMT1 (hnRNP methyltransferase, S. cerevisiae)	3
411060	NM_006074	Hs. 295978	stimulated trans-acting factor (50 kDa)	3
406805	AI686003	Hs. 296031	ESTs	3
426159	Z44524	Hs. 167456	Homo sapiens mRNA full length insert cDNA clo	3
432134	AI816782	Hs. 122583	Homo sapiens cDNA: FLJ21934 fis, clone HEP043	3
454314	AW364844		gb: QV3-DT0044-221299-045-c03 DT0044 Homo sapi	3
441975	AW173248	Hs. 250139	ESTs	3
450937	R49131	Hs. 26267	ATP-dependant interferon response protein 1	3
433529	AA598547	Hs. 222405	ESTs	3
454024	AA993527	Hs. 16281	hypothetical protein FLJ23403	3
459352	AW810383	Hs. 206828	ESTs	3
444454	BE018316	Hs. 11183	sorting nexin 2	3
448760	AA313825	Hs. 21941	ESTs	3
456328	T41368		gb: ph1d1_19/1TV Outward Alu-primed hncDNA lib	3
416803	T79239	Hs. 168541	Homo sapiens mRNA full length insert cDNA clo	3
418875	W19971	Hs. 233459	ESTs	3
432718	AA563943	Hs. 244371	ESTs	3
456236	AF045229	Hs. 82280	regulator of G-protein signalling 10	3
402725	c1p1_6627		predicted exon	3
408989	AW361666	Hs. 49500	KIAA0746 protein	3
430478	NM_014349	Hs. 241535	TNF-inducible protein CG12-1	3
436424	AA716190	Hs. 39056	ESTs	3
404345	AA730407	Hs. 159156	protocadherin 11	3
442049	AA310393	Hs. 299263	ESTs	3
454119	BE549773	Hs. 40510	uncoupling protein 4	3
417282	AA195203	Hs. 479	RAB5C, member RAS oncogene family	3
452436	BE077546	Hs. 31447	ESTs	3
410706	AI732404	Hs. 68846	ESTs	3
405246	cNp1_8370		predicted exon	3
430857	AW804964	Hs. 248069	Human BAC clone CTB-7J15 from 7q31	3
435403	AA779987	Hs. 269658	ESTs	3
447982	H22953	Hs. 137551	ESTs	3
432680	T47364	Hs. 278613	interferon, alpha-inducible protein 27	3
452774	AA047374	Hs. 103388	ESTs, Weakly similar to I38022 hypothetical p	3
417052	NM_000712	Hs. 81029	biliverdin reductase A	3
448959	AI610343	Hs. 186355	ESTs	3
420299	AI056871	Hs. 15276	ESTs	3
409703	NM_006187	Hs. 56009	2′-5′oligoadenylate synthetase 3	3
454413	AI653672	Hs. 40092	ESTs	3
437175	AW968078	Hs. 87773	protein kinase, cAMP-dependent, catalytic, be	3
437456	AL047045	Hs. 60293	Homo sapiens clone 122482 unknown mRNA	3
453408	AI804732	Hs. 295963	ESTs	3
436563	AJ239450	Hs. 157874	ESTs	3
448901	AK001021	Hs. 22505	hypothetical protein FLJ10159	3
439649	T64781	Hs. 6618	Homo sapiens cDNA FLJ20782 fis, clone COL0384	3
453887	BE564037	Hs. 36237	CGI-34 protein	3
407756	AA116021	Hs. 38260	ubiquitin specific protease 18	3
444222	AW580955	Hs. 146236	ESTs	3
416670	N69267	Hs. 26073	ESTs, Moderately similar to HG14_HUMAN NONHIS	3
418230	AI917753	Hs. 126639	ESTs	3
431049	AA846576	Hs. 103267	hypothetical protein FLJ22548 similar to gene	3
417787	R14948	Hs. 23883	ESTs	3
421165	AA284420		gb: zs59c08.r1 NCI_CGAP_GCB1 Homo sapiens cDNA	3
433297	AV658581	Hs. 282633	ESTs	3
445044	AL137728	Hs. 12258	Homo sapiens mRNA; cDNA DKFZp434B0920 (from c	3
418945	BE246762	Hs. 89499	arachidonate 5-lipoxygenase	3
423706	U95218	Hs. 131924	G protein-coupled receptor 65	3
422630	AA313606	Hs. 125509	hypothetical protein FLJ10648	3
416389	AA180072	Hs. 149846	integrin, beta 5	3
432954	AI076345	Hs. 214199	ESTs, Weakly similar to ALUB_HUMAN !!!! ALU C	3
435688	H72286	Hs. 128387	ESTs	3
447453	AW608645	Hs. 158946	ESTs	3
454278	AF217525	Hs. 49002	Down syndrome cell adhesion molecule	3
432485	N90866	Hs. 276770	CDW52 antigen (CAMPATH-1 antigen)	3
442584	AW976853	Hs. 172843	ESTs	3
426110	NM_002913	Hs. 166563	replication factor C (activator 1) 1 (145 kD)	3
450433	AW444538	Hs. 231863	ESTs	3
404085	c6p1_11412	predicted exon
444743	AA045648	Hs. 11817	nudix (nucleoside diphosphate linked moiety X	3
416503	H98502	Hs. 269853	ESTs	3
421727	Y13153	Hs. 107318	kynurenine 3-monooxygenase (kynurenine 3-hydr	3
458082	AW978811	Hs. 168213	ESTs, Weakly similar to ALU1_HUMAN ALU SUBFAM	3
437374	AL359571	Hs. 12772	KIAA1565 protein	3
428079	AA421020	Hs. 208919	ESTs	3
451079	AI827988	Hs. 240728	ESTs	3
408212	AA297567	Hs. 43728	hypothetical protein	3
417793	AW405434	Hs. 82575	small nuclear ribonucleoprotein polypeptide B	3
430697	AA484207	Hs. 211867	ESTs	3
453828	AW970960	Hs. 293821	ESTs	3
416784	AA334592	Hs. 79914	lumican	3
445823	AI478563	Hs. 145519	ESTs	3
419586	AI088485	Hs. 144759	ESTs	3
440857	AA907808	Hs. 135556	ESTs	3
455065	AW854352		gb: RC3-CT0255-200100-024-g10 CT0255 Homo sapi	3
450607	AL050373	Hs. 25213	hypothetical protein	3
442445	AA082665	Hs. 209561	ESTs, Weakly similar to C05E11.1 gene product	3
437868	F05965	Hs. 134441	ESTs	3
441664	AW748420	Hs. 6236	Homo sapiens cDNA: FLJ21487 fis, clone COL054	3
409461	AA382169	Hs. 54483	N-myc (and STAT) interactor	3
409977	AW805510	Hs. 97056	hypothetical protein FLJ21634	3
446266	AI417271	Hs. 163949	ESTs	3
429623	NM_005308	Hs. 211569	G protein-coupled receptor kinase 5	3
447540	AL135716	Hs. 263780	ESTs	3
441021	AW578716	Hs. 7644	H1 histone family, member 2	3
448766	AI473827	Hs. 31793	ESTs	3
413278	BE563085	Hs. 833	interferon-stimulated protein, 15 kDa	3
450293	N36754	Hs. 171118	Homo sapiens mRNA for FLJ00026 protein, parti	3
421908	AW935200	Hs. 243852	ESTs, Weakly similar to ALU5_HUMAN ALU SUBFAM	3
414915	NM_002462	Hs. 76391	myxovirus (influenza) resistance 1, homolog o	3
414489	AI620677	Hs. 154191	ESTs	3
433637	AW024214	Hs. 135405	ESTs	3
446428	AW082270	Hs. 210617	ESTs, Weakly similar to ALU4_HUMAN ALU SUBFAM	2
424528	AW073971	Hs. 238954	ESTs, Weakly similar to KIAA1204 protein [H.s	2
419034	NM_002110	Hs. 89555	hemopoietic cell kinase	2
419138	U48508	Hs. 89631	ryanodine receptor 1 (skeletal)	2
405031	H25530	Hs. 50868	solute carrier family 22 (organic cation tran	2
438459	T49300	Hs. 35304	Homo sapiens cDNA FLJ13655 fis, clone PLACE10	2
429752	H52348	Hs. 36636	ESTs	2
418827	BE327311	Hs. 47166	EST; HT021 mRNA	2
423855	AA331761	Hs. 254859	ESTs	2
442989	BE567710		gb: 601340367F1 NIH_MGC_53 Homo sapiens cDNA c	2
438493	AI130740	Hs. 6241	phosphoinositide-3-kinase, regulatory subunit	2
420338	AA825595	Hs. 88269	ESTs, Highly similar to GPRI_HUMAN PROBABLE G	2
432610	BE246615	Hs. 278507	histidyl-tRNA synthetase-like	2
431629	AU077025	Hs. 265827	interferon, alpha-inducible protein (clone IF	2
458752	AW292842	Hs. 255128	ESTs	2
405955	ph0_1394		predicted exon	2
430320	BE245290	Hs. 239218	uncharacterized hypothalamus protein HCDASE	2
441892	AB028981	Hs. 8021	KIAA1058 protein	2
424030	AB015046	Hs. 137580	xylulokinase (H. influenzae) homolog	2
407347	AA829847	Hs. 167347	ESTs, Weakly similar to ALU8_HUMAN ALU SUBFAM	2
416517	AA775987	Hs. 79357	proteasome (prosome, macropain) 26S subunit,	2
415000	AW025529	Hs. 239812	ESTs, Weakly similar to CALM_HUMAN CALMODULIN	2
451652	AA018968	Hs. 133536	ESTs	2
435497	AW021655	Hs. 194441	ESTs	2
448554	NM_016169	Hs. 21431	suppressor of fused	2
408405	AK001332	Hs. 44672	hypothetical protein FLJ10470	2
447769	AW873704	Hs. 48764	ESTs	2
447514	AI809314	Hs. 208501	ESTs	2
430291	AV660345	Hs. 238126	CGI-49 protein	2
426108	AA622037	Hs. 166468	programmed cell death 5	2
410240	AL157424	Hs. 61289	synaptojanin 2	2
415579	AA165232	Hs. 222069	ESTs	2
418838	AW385224	Hs. 35198	ESTs	2
427528	AU077143	Hs. 179565	minichromosome maintenance deficient (S. cere	2
452696	AI826645	Hs. 211534	ESTs	2
459252	AF043467	Hs. 32893	neurexophilin 2	2
408360	AI806090	Hs. 44344	hypothetical protein FLJ20534	2
414511	AA148725	Hs. 12969	hypothetical protein	2
422938	NM_001809	Hs. 1594	centromere protein A (17 kD)	2
452670	AF068227	Hs. 30213	ceroid-lipofuscinosis, neuronal 5	2
407332	AI801565	Hs. 200113	Homo sapiens cDNA FLJ11379 fis, clone HEMBA10	2
402107	c18p1_7398	predicted exon
413048	M93221	Hs. 75182	mannose receptor, C type 1	2
431863	AA188185	Hs. 271871	Spindlin	2
416450	AA180467	Hs. 142556	ESTs	2
419369	W28557		gb: 48d8 Human retina cDNA randomly primed sub	2
447023	AA356764	Hs. 17109	integral membrane protein 2A	2
449420	AI654852	Hs. 196562	ESTs, Highly similar to TS24 MOUSE PROTEIN TS	2
418721	NM_002731	Hs. 87773	protein kinase, cAMP-dependent, catalytic, be	2
441941	AI953261	Hs. 169813	ESTs	2
408393	AW015318	Hs. 23165	ESTs	2
450746	D82673	Hs. 169921	general transcription factor II, i, pseudogen	2
452598	AI831594	Hs. 68647	ESTs, Weakly similar to ALU7_HUMAN ALU SUBFAM	2
427719	AI393122	Hs. 134726	ESTs	2
452852	AK001972	Hs. 30822	hypothetical protein FLJ11110	2
440266	AA088809	Hs. 19525	hypothetical protein FLJ22794	2
423613	AF036035	Hs. 129910	hyaluronoglucosaminidase 3	2
443601	AI078554	Hs. 15682	ESTs	2
432005	AA524190	Hs. 120777	ESTs, Weakly similar to ELL2_HUMAN RNA POLYME	2
427794	AA709186	Hs. 111973	ESTs	2
417831	H16423	Hs. 82685	CD47 antigen (Rh-related antigen, integrin-as	2
435981	H74319	Hs. 188620	ESTs	2
408077	AL133574	Hs. 42458	Homo sapiens mRNA; cDNA DKFZp586C1817 (from c	2
426312	AF026939	Hs. 181874	interferon-induced protein with tetratricopep	2
440561	AA471379	Hs. 7277	peroxisomal biogenesis factor 3	2
407748	AL079409	Hs. 38176	KIAA0606 protein; SCN Circadian Oscillatory P	2
407213	T16206	Hs. 237164	ESTs, Highly similar to LDHH_HUMAN L-LACTATE	2
449204	AB000099	Hs. 23251	Down syndrome critical region gene 4	2
433364	AI075407	Hs. 296083	ESTs	2
419216	AU076718	Hs. 164021	small inducible cytokine subfamily B (Cys-X-C	2
425987	AW015005	Hs. 165662	KIAA0675 gene product	2
401263	AB033113	Hs. 50187	KIAA1287 protein	2
452194	AI694413	Hs. 298262	ESTs, Weakly similar to dJ88J8.1 [H. sapiens]	2
415668	AW957684	Hs. 77324	eukaryotic translation termination factor 1	2
401069	c11p3_633		predicted exon	2
416475	T70298		gb: yd26g02.s1 Soares fetal liver spleen 1NFLS	2
443303	U67319	Hs. 9216	caspase 7, apoptosis-related cysteine proteas	2
423095	S75989	Hs. 123639	solute carrier family 6 (neurotransmitter tra	2
437575	AW954355	Hs. 36529	ESTs	2
458679	AW975460	Hs. 143563	ESTs	2
446506	AI123118	Hs. 15159	transmembrane proteolipid	2
409132	AJ224538	Hs. 50732	protein kinase, AMP-activated, beta 2 non-cat	2
425508	AA991551	Hs. 97013	ESTs	2
419644	AU076951	Hs. 91797	retinoblastoma-binding protein 1	2
427639	AW444530	Hs. 105362	ESTs	2
427209	H06509	Hs. 92423	KIAA1566 protein	2
423235	AW410698		gb: fh07h04.x1 NIH_MGC_17 Homo sapiens cDNA cl	2
434961	AW974956		gb: EST387061 MAGE resequences, MAGN Homo sapi	2
437594	AA761431	Hs. 283318	ESTs	2
407687	AK002011	Hs. 37558	hypothetical protein FLJ11149	2
443119	AA312264	Hs. 7980	ESTs, Moderately similar to ALU4_HUMAN ALU SU	2
446591	H44186	Hs. 15456	PDZ domain containing 1	2
442160	AI337127	Hs. 156325	ESTs	2
406475	ph2_23228		predicted exon	2
448965	AF092134	Hs. 22679	CGI-24 protein	2
424243	AI949359	Hs. 301837	ESTs, Highly similar to cis Golgi-localized c	2
442048	AA974603		gb: op34f05.s1 Soares_NFL_T_GBC_S1 Homo sapien	2
412530	AA766268	Hs. 266273	Homo sapiens cDNA FLJ13346 fis, clone OVARC10	2
447922	Z92910	Hs. 20019	hemochromatosis	2
415277	R44607	Hs. 22672	ESTs	2
450770	AA019924	Hs. 28803	ESTs	2
446946	AI878932	Hs. 317	topoisomerase (DNA) I	2
448569	BE382657	Hs. 21486	signal transducer and activator of transcript	2
427581	NM_014788	Hs. 179703	KIAA0129 gene product	2
407645	AW062509		gb: MR0-CT0069-120899-001-b12 CT0069 Homo sapi	2
408179	AL042465	Hs. 43445	poly(A)-specific ribonuclease (deadenylation	2
402716	c1p1_6479		predicted exon	2
447474	AW614220	Hs. 189402	ESTs	2
452705	H49805	Hs. 246005	ESTs	2
436643	AA757626	Hs. 10941	ESTs, Weakly similar to IPP1_HUMAN PROTEIN PH	2
451625	R56793	Hs. 106576	ESTs	2
448233	AI478114	Hs. 190615	ESTs	2
427094	AB025254	Hs. 283761	tudor repeat associator with PCTAIRE 2	2
438011	BE466173	Hs. 145696	splicing factor (CC1.3)	2
430024	AI808780	Hs. 227730	integrin, alpha 6	2
424840	D79987	Hs. 153479	extra spindle poles, S. cerevisiae, homolog o	2
447547	NM_007229	Hs. 18842	protein kinase C and casein kinase substrate	2
418259	AA215404	Hs. 137289	ESTs	2
449119	AI631195	Hs. 232193	ESTs	2
417377	NM_016603	Hs. 82035	GAP-like protein	2
415535	T65331		gb: yc74e08.r1 Soares infant brain 1NIB Homo s	2
455225	AW996689		gb: QV3-BN0046-150400-151-g09 BN0046 Homo sapi	2
404015	c5p1_9512		predicted exon	2
419515	S81944	Hs. 90791	gamma-aminobutyric acid (GABA) A receptor, al	2
438874	H02780		gb: yj41a11.r1 Soares placenta Nb2HP Homo sapi	2
457625	T10073		gb: seq1293 b4HB3MA Cot8-HAP-Ft Homo sapiens c	2
444151	AW972917	Hs. 128749	alpha-methylacyl-CoA racemase	2
408072	BE005566	Hs. 16773	Homo sapiens clone TCCCIA00427 mRNA sequence	2
423568	NM_005256	Hs. 129818	growth arrest-specific 2	2
455514	AW983871		gb: RC1-HN0003-220300-021-h07 HN0003 Homo sapi	2
454167	AW176543		gb: MR0-CT0062-200899-002-b04 CT0062 Homo sapi	2
414792	BE314949	Hs. 235775	ESTs	2
453779	N35187	Hs. 43388	ESTs	2
422932	AI191813		gb: qd47f06.x1 Soares_fetal_heart_NbHH19W Homo	2
421257	BE298539	Hs. 15536	ESTs, Weakly similar to CNBP_HUMAN CELLULAR N	2
408411	C15118	Hs. 251967	Homo sapiens clone 785627 unknown mRNA	2
408587	AW238039	Hs. 253909	ESTs	2
405545	cNp3_24204	predicted exon
408683	R58665	Hs. 46847	TRAF and TNF receptor-associated protein	2
405392	cNp3_16759	predicted exon
437613	R19892	Hs. 10267	MIL1 protein	2
439645	BE091801	Hs. 27167	ESTs	2
457498	AI732230	Hs. 191737	ESTs	2
449567	AI990790	Hs. 188614	ESTs	2
418791	AA935633	Hs. 194628	ESTs	2
437838	AI307229	Hs. 184304	ESTs	2
447735	AA775268	Hs. 6127	Homo sapiens cDNA: FLJ23020 fis, clone LNG009	2
416240	NM_001981	Hs. 301245	Homo sapiens clone 23743 mRNA sequence	2
424321	W74048	Hs. 1765	lymphocyte-specific protein tyrosine kinase	2
452664	AA398859	Hs. 18397	Homo sapiens cDNA: FLJ23221 fis, clone ADSU01	2
433370	AI084343	Hs. 122310	ESTs	2
439559	AW364675	Hs. 173921	ESTs	2
413129	AF292100	Hs. 104613	RP42 homolog	2
445786	AW629819	Hs. 144502	Homo sapiens cDNA: FLJ22055 fis, clone HEP096	2
453469	AB014533	Hs. 33010	KIAA0633 protein	2
458020	AW515443	Hs. 249495	heterogeneous nuclear ribonucleoprotein A1	2
412019	AA485890	Hs. 69330	Homo sapiens cDNA FLJ13835 fis, clone THYRO10	2
448873	NM_003677	Hs. 22393	density-regulated protein	2
409549	AB029015	Hs. 54886	phospholipase C, epsilon 2	2
450669	AL138077	Hs. 16157	hypothetical protein FLJ12707	2
433017	Y15067	Hs. 279914	zinc finger protein 232	2
435726	BE535787	Hs. 113170	ESTs	2
434568	AA584069	Hs. 222027	ESTs	2
402524	c1p1_17748	predicted exon
428388	AA729827	Hs. 101265	Homo sapiens cDNA: FLJ22593 fis, clone HSI032	2
453085	AW954243	Hs. 170218	KIAA0251 protein	2
449082	BE387561	Hs. 22981	DKFZP586M1523 protein	2
422459	K02100	Hs. 117050	ornithine carbamoyltransferase	2
430007	NM_014892	Hs. 227602	KIAA1116 protein	2
421494	AI763322	Hs. 152104	ESTs	2
422241	Y00062	Hs. 170121	protein tyrosine phosphatase, receptor type,	2
401445	c14p3_4294	predicted exon
414747	U30872	Hs. 77204	centromere protein F (350/400 kD, mitosin)	2
416980	AA381133	Hs. 80684	high-mobility group (nonhistone chromosomal)	2
419270	NM_005232	Hs. 89839	EphA1	2
447164	AF026941	Hs. 17518	Homo sapiens cig5 mRNA, partial sequence	2
452576	AB023177	Hs. 29900	KIAA960 protein	2
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Diseased Liver: Non-diseased Liver

[0336]

TABLE 1B
Pkey	CAT Number	Accession
455743	1496056_1	BE073795 BE073756 BE073796 BE073754 BE073752 BE073755 BE073733 BE073753 BE073704
		BE073695 BE073791
413541	1519670_1	BE147036 BE146951 BE146976 BE146966 BE146958 BE146955
410527	1030469_1	AW851066 AW851076 AW851065 AW752861 BF511007 AW851140 AW851166 AW999129 AW850779
		AW850786
411466	1085200_1	AW847669 AW847667 AW847668 BE145799
447513	450115_1	AW955776 AW264910 AI401003 AI382588 D20260 N74904 H57056 R26462 AV735490
456383	250410_1	AA236756 AA287178 AI148037
450560	50855_1	NM_024331 BC003071 BM012414 BE315221 BG750119 BE272198 AL449476 BE886722 AI360302
		BG002949 BM454474 AL449598 BM012506
		BE383204 AA010225 AL449685 AL449684 BF742320 T06328
419375	2390505_1	W27916 W26506
410430	5482_6	BG120564 BG705653 BF846503 BF995692 BE311644
454750	1070828_1	AW866285 AW866541 AW819153 AW819000 AW819014
411857	1112533_1	AW867707 AW879403
455960	1554632_1	BE165256 BE165247 BE165239 BE165233 BE165264 BE165262 BE165261 BE165252 BE165251
		BE165245 BE165203 BE165201 BE165242
		BE165206 BE165175 BE165232 BE165184 BE165197 BE165194 BE165193 BE165246 BE165240 BE165186
		BE165237 BE165180
442431	MH1944_19	AW886349 AI818145 BE463452 BF002624 AI360447 AI634842 AI362712 BE349856 W74084 AW014214
		W72374 AA995742 R80905 R80906
433854	899720_1	BG675161 H59558 AI699484 AA610649 AI937812
431300	1529181_1	BE159863 AA502346 AU186097 R86267 H71358
410833	1061214_1	AW806900 BF373960 BF373956 AW866317 AW866524 AW866625 BF373959 AW866592
455708	1493321_1	BE069290 BE069352 BE069326
425195	12922_3	BG197420 BG219369 BG182827 AA352026
457707	114453_1	AA640546 AW974642 AA649509 AA649527
413605	1523960_1	BE152811 BE152651 BE152644 BE152659 BE152810 BE152714 BE152707 BE152643 BE152660 BE152669
		BE152711 BE152808 BE152782
		BE152678 BE152682 BE152813 BE152778 BF350474 BE152776 BE152781 BE152774 BF350475 BE152712
		BE152706 BE152668 BE152814
		BE152671 BE152652 BE152760 BE152767 BE152775 BE152815 BE152715 BE152681 BE152771 BE152661
		BE152780 BE152763 BE152666
		BE152708 BE152665 BE152664 BE152677 BE152662 BE152768 BE152709 BE152679 BE152667 BE152673
		BE152676 BE152656 BE152769
		BE152816 BE152809 BE152672 BE152653 BE152716 BE152762
433586	32908_1	BC011194 AW517087 AA601054 T85512
454314	773174_1	AW364844 AW364847 AW937534 AW937593 AW937659
456328	2306193_1	T41294 T41304 T41368 T41369
421165	50467_2	BG620396 AA428945 H89283 AA831889 AI039537 BG573209 AA284420 AI267186 H97302
455065	1094993_1	AW854352 AW854461 AW854311 AW854340
442989	1768039_1	BE567710 R02368
419369	856237_1	W28557 BG619281 W26273
416475	1972665_1	R02750 H58072 T70298 BF367306 R02749 T80873
423235	7447_1	BC016162 AK054907 BC008564 BC011232 AL533635 BF508705 AA521407 AA521325 AI400703
		AI439041 BF726761 AI440391 AW451413
		AI127908 BE463710 AI076067 AI380502 AI249172 AI475513 AI932260 AA598632 AW503511 BF111247
		AA516001 AI435214 AW295486
		AI251854 BI963232 AI242565 AI247008 AI621262 AI766708 AJ401189 NM_032595 AI523759 AW028349
		AW302139 AI808223 AI475761
		BE895415 BI912507 AA323578 BF951255 BF947949 AA323535 BF947948 BF448737 BF515503 BF109903
		AI969706 AI356745 BF476688
		AI475690 AW082861 AI056581 AI521266 AA889737 BM461771 BM129164 BI909136 BF874611 BE909797
		BI755397 BI052380 BF973595
		BI052420 BI012504 BF806956 BI052419 AA444012 BF848781 BF091592 AA884981
434961	121331_1	AA781075 AA654944 AW974956
442048	750422_1	AW340495 AI984319 AA974603
407645	579939_1	AW062509 AW845614 BE140931 AW845635
415535	1875630_1	T65331 F11774 F11773
455225	1113920_1	AW868687 AW996453 AW996689 AW996380 BE085650 BE085595
438874	52147_1	AF075017 R66779 R22463 H02780
457625	433710_1	H14872 T10073 AV723827 AA604786
455514	1243022_1	AW983860 BE090302 AW983845 AW983853 AW983871 AW983867 AW983852
454167	1048866_1	AW176543 AW806978 BE141056 AW806985 AW178964 AW845681
422932	9154_11	H83343 AW954934 AA417867 AA319212
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0337]

TABLE 1C
402811	6523646	Plus	101679-101844
403747	7658395	Minus	20493-20621
406367	9256126	Minus	58313-58489
404287	2326514	Plus	53134-53281
402725	8979991	Plus	107231-107383
405246	7249293	Minus	82725-82884
405955	6758797	Plus	39940-40092
401069	3927852	Minus	45682-45831
406475	9797684	Plus	125417-125563, 128052-128180
402716	8969253	Minus	84065-84242
404015	8655948	Minus	587821-588222
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0338]

TABLE 2A
ABOUT 535 GENES DOWNREGULATED IN HEPATITIS C [see 60/308, 188]
Pkey	ExAccn	UnigeneID	Title	Ratio
450912	AW939251	Hs. 25647	v-fos FBJ murine osteosarcoma viral onco	2
447078	AW885727	Hs. 301570	ESTs	2
442941	AU076728	Hs. 8867	cysteine-rich, angiogenic inducer, 61	2
419564	U08989	Hs. 91139	solute carrier family 1 (neuronal/epithe	2
447771	BE505004	Hs. 280838	ESTs	2
444286	AI625304	Hs. 190312	ESTs	2
436711	AW452601	Hs. 189907	ESTs	2
434078	AW880709	Hs. 283683	EST	2
442570	AI001834	Hs. 130264	ESTs	2
453270	AI971439	Hs. 233461	ESTs	2
410140	AL134435	Hs. 27872	ESTs	2
404839	cAp3_4046			2
418138	AA213626	Hs. 136204	EST	2
444541	AI161257	Hs. 167252	ESTs	2
408098	R61857	Hs. 120981	ESTs	2
400959	c11p1_3967			2
403397	c3p1_11672			2
440948	AW188311	Hs. 128619	ESTs	2
444648	AI221297	Hs. 147778	ESTs, Weakly similar to KIAA0454 protein	2
404723	c9p1_8723			2
451400	BE160479		gb: QV1-HT0413-210200-081-g05 HT0413 Homo	2
432228	AA335178	Hs. 274124	Human DNA sequence from clone 1018D12 on	2
415328	Z44310		gb: HSC1XF011 normalized infant brain cDN	2
445967	D59597	Hs. 118821	CGI-62 protein	2
444776	AI191980	Hs. 145430	ESTs	2
447875	R22029	Hs. 13905	ESTs	2
408834	AW276241		gb: xr08f06.x1 NCI_CGAP_Lu28 Homo sapiens	2
458099	AW263124	Hs. 34782	ESTs	2
440634	AA921767	Hs. 132447	ESTs	2
442786	H50733	Hs. 256261	ESTs	2
415477	NM_002228	Hs. 78465	v-jun avian sarcoma virus 17 oncogene ho	2
407516	X64974		gb: H. sapiens mRNA HTPCRH02 for olfactory	2
455806	BE141094		gb: MR0-HT0075-121199-004-e05 HT0075 Homo	2
421370	AA287904	Hs. 269669	ESTs	2
430737	AW364181	Hs. 208763	ESTs	2
404398	c7p3_782			2
418998	F13215	Hs. 287849	ESTs	2
426566	AF131836	Hs. 170453	tropomodulin	2
445225	AI216555	Hs. 202398	ESTs	2
455181	AW863568		gb: MR3-SN0010-240300-102-c10 SN0010 Homo	2
457752	AI821270	Hs. 116930	ESTs	2
405475	cNp3_19914			2
423167	AA770464		gb: ah89g09.s1 Soares_NFL_T_GBC_S1 Homo s	2
414559	AV656184	Hs. 76452	C-reactive protein, pentraxin-related	2
459263	L25475		gb: HUM21ES116 ClonTech HL 1065a Home sap	2
455175	AW993247		gb: RC2-BN0033-180200-014-h09 BN0033 Homo	2
454448	AW750209		gb: RC5-BT0562-260100-011-H03 BT0562 Homo	2
417566	T81449	Hs. 191199	ESTs	2
404498	c8p1_4579			2
418501	BE079398	Hs. 5921	Homo sapiens cDNA: FLJ21592 fis, clone C	2
409113	AA074897		gb: zm85a05.r1 Stratagene ovarian cancer	2
401074	c11p3_815			2
456304	AI820973	Hs. 188706	ESTs	2
459689	AA584858		ESTs	2
423669	AA329417	Hs. 272321	Homo sapiens cDNA FLJ12571 fis, clone NT	2
441884	AW172630	Hs. 144884	ESTs	2
441837	AA361743	Hs. 179881	core-binding factor, beta subunit	2
400371	U80740	Hs. 278692	trinucleotide repeat containing 8	2
439034	AF075083		gb: Homo sapiens full length insert cDNA	2
439075	AF085933	Hs. 292620	ESTs	2
415350	R13218		gb: yf74c05.r1 Soares infant brain 1NIB H	2
427668	AA298760	Hs. 180191	Homo sapiens mRNA; cDNA DKFZp434L0217 (f	2
457103	AI421187	Hs. 189192	ESTs	2
433970	AA721401	Hs. 301908	ESTs	2
442314	AI311854	Hs. 129220	ESTs	2
435332	AA678019	Hs. 187994	ESTs	2
451740	R63962	Hs. 269210	ESTs	2
458198	AI286100	Hs. 192739	ESTs	2
428959	AF100779	Hs. 194680	WNT1 inducible signaling pathway protein	2
445211	BE045601	Hs. 118248	ESTs, Weakly similar to YC18_HUMAN HYPOT	2
459695	AA381579		ESTs	2
411355	AW838479	Hs. 22692	ESTs	2
401887	c17p1_704			2
406285	AW068311	Hs. 82582	integrin, beta-like 1 (with EGF-like rep	2
439201	AW503578	Hs. 209406	ESTs, Weakly similar to Z140_HUMAN ZINC	2
407760	T79084	Hs. 184407	ESTs	2
451886	T63790	Hs. 293720	Homo sapiens cDNA: FLJ22804 fis, clone K	2
423657	AL045128	Hs. 1691	glucan (1,4-alpha-), branching enzyme 1	2
426529	AF090100	Hs. 170241	Homo sapiens clone IMAGE 23915	2
440728	AW086077	Hs. 153272	Homo sapiens cDNA: FLJ22715 fis, clone H	2
445061	AI253094	Hs. 145227	ESTs	2
421013	M62397	Hs. 1345	mutated in colorectal cancers	2
430873	AW269813	Hs. 154395	ESTs	2
407850	AW086230	Hs. 244912	ESTs	2
426077	AA448328	Hs. 115527	ESTs	2
419927	R53365	Hs. 20001	ESTs	2
433945	AI024718	Hs. 112873	ESTs	2
434554	R13594	Hs. 301529	ESTs	2
418625	AW948578	Hs. 136211	ESTs	2
453523	NM_012118	Hs. 258586	CCR4-like (carbon catabolite repression	2
455195	AW864370		gb: PM4-SN0016-100500-004-h09 SN0016 Homo	2
406547	ph2_5308			2
416510	H60055	Hs. 169833	single-stranded-DNA-binding protein	2
415737	AA167626	Hs. 118743	ESTs	2
431895	H60210	Hs. 272003	hemoglobin, zeta	2
402468	c1p1_13012			2
454042	H22570	Hs. 172572	hypothetical protein FLJ20093	2
401943	NM_012434	Hs. 117865	solute carrier family 17 (anion/sugar tr	2
412065	R82597	Hs. 176648	ESTs	2
444601	AV650521	Hs. 282449	ESTs	2
438247	AI018016	Hs. 131222	ESTs	2
441224	AU076964	Hs. 7753	calumenin	2
449463	AI657038	Hs. 196109	ESTs	2
451029	AA852097	Hs. 25829	ras-related protein	2
419728	L36861	Hs. 92858	guanylate cyctase activator 1A (retina)	2
436763	AI168278	Hs. 128713	ESTs	2
411861	AW867875		gb: MR0-SN0040-050500-003-f11 SN0040 Homo	2
449278	AI637876	Hs. 224372	ESTs	2
456576	AA287443		gb: zs52c10.r1 NCI_CGAP_GCB1 Homo sapiens	2
432240	AI694767	Hs. 129179	ESTs	2
447788	AI424822	Hs. 161430	ESTs	2
405278	cNp3_1070			2
408332	H91230	Hs. 234794	Homo sapiens mRNA; cDNA DKFZp564B083 (fr	2
454442	AW816134		gb: MR3-ST0220-290100-016-e04 ST0220 Homo	2
454520	AW803371		gb: IL2-UM0079-090300-049-B06 UM0079 Homo	2
437103	AW139408	Hs. 152940	ESTs	2
458254	BE091969	Hs. 127742	ESTs	2
415075	L27479	Hs. 77889	Friedreich ataxia region gene X123	2
450577	AW612816	Hs. 202057	ESTs	2
414564	AA164803	Hs. 71994	ESTs	2
459349	AW749381		gb: QV3-BT0381-170100-060-c02 BT0381 Homo	2
450581	AF081513	Hs. 25195	endometrial bleeding associated factor	2
445239	AI217375	Hs. 170023	ESTs, Weakly similar to collagen alpha 3	2
421227	R78581	Hs. 266308	ESTs, Weakly similar to AF216312 1 type	2
432675	AI791855	Hs. 105884	ESTs	2
451831	NM_001674	Hs. 460	activating transcription factor 3	2
455104	BE064863		gb: RC1-BT0313-110300-015-f06 BT0313 Homo	2
441445	AI221959	Hs. 187937	ESTs	2
405456	cNp3_18813			2
452747	BE153855	Hs. 61460	Ig superfamily receptor LNIR precursor	2
449438	AA927317	Hs. 176719	ESTs	2
437662	AA765387	Hs. 145095	ESTs	2
443258	AF169301	Hs. 9098	sulfate transporter 1	2
448670	AW296257	Hs. 230507	ESTs	2
425426	AB021641	Hs. 157203	Homo sapiens GIOT-1 mRNA for gonadotropi	2
446438	AI299876	Hs. 150061	ESTs	2
457005	AJ007421	Hs. 300698	ESTs, Highly similar to spalt-like zinc	2
407473	L10404		gb: Homo sapiens DNA binding protein for	2
404319	c7p1_2230			2
429836	AW117452	Hs. 99489	ESTs	2
416461	AA180526	Hs. 216797	ESTs	2
435185	AA669490	Hs. 289109	dimethylarginine dimethylaminohydrolase	2
403600	c3p1_6888			2
401775	c17p1_11738			2
424200	AA337221		gb: EST41944 Endometrial tumor Homo sapie	2
405532	cNp3_23494			2
424404	AA340151	Hs. 104650	hypothetical protein FLJ10292	2
427168	AA398821	Hs. 97548	ESTs	2
430071	AA355986	Hs. 232068	transcription factor 8 (represses interl	2
423290	AA324130		gb: EST27023 Cerebellum II Homo sapiens c	2
429295	AA682377	Hs. 99216	ESTs, Moderately similar to ALU8_HUMAN A	2
445571	AI378000	Hs. 158489	ESTs, Weakly similar to b3418.1 [H.sapie	2
432459	AW291917	Hs. 174387	ESTs	2
424584	H10692	Hs. 13310	ESTs	2
401411	c14p3_2875			2
429932	AI095005	Hs. 135174	ESTs	2
449305	AI638293		gb: tt09b07.x1 NCI_CGAP_GC6 Homo sapiens	2
413257	BE075035		gb: PM3-BT0584-260300-002-g05 BT0584 Homo	2
436062	AK000027	Hs. 98633	ESTs	2
430692	X80240		gb: H. sapiens endogenous retrovirus HERV-	2
403212	c2p1_2196			2
424686	AA345504		gb: EST51529 Gall bladder II Homo sapiens	2
413272	AA127923	Hs. 293256	ESTs	2
411658	AW855598		gb: CM1-CT0278-031199-032-e08 CT0278 Homo	2
459721	AI299050		gb: qn14d12.x1 NCI_CGAP_Lu5 Homo sapiens	2
404834	cAp3_3862			2
442484	AF075360		gb: AF075360 Human fetal liver cDNA libra	2
411689	AW857121		gb: RC1-CT0302-040400-017-a12 CT0302 Homo	2
407707	AW294785	Hs. 143895	Homo sapiens cDNA: FLJ21140 fis, clone C	2
433430	AI863735	Hs. 186755	ESTs	2
401866	c17p1_5127			2
400352	AF227133	Hs. 272389	Homo sapiens candidate taste receptor T2	2
444862	AI209158	Hs. 143929	ESTs	2
401558	c15p1_539			2
405698	cNp3_9135			2
427731	AA411750	Hs. 20943	ESTs	2
411486	N85785	Hs. 181165	eukaryotic translation elongation factor	2
438557	AW364104	Hs. 143509	Homo sapiens cDNA: FLJ21924 fis, clone H	2
411902	AW875344		gb: RC1-PT0009-220300-013-f06 PT0009 Homo	2
444573	AW043590	Hs. 225023	ESTs	2
420355	AW968263	Hs. 123126	ESTs	2
418225	AA747676		gb: nx85g05.s1 NCI_CGAP_GCB1 Homo sapiens	2
404974	cNp1_15731			3
410993	BE138999	Hs. 278868	ESTs	3
410900	AW810169		gb: MR4-ST0124-040500-007-h07 ST0124 Homo	3
445626	AI400253	Hs. 156240	ESTs	3
449986	AW864502		gb: PM4-SN0016-120400-004-b12 SN0016 Homo	3
413088	BE064962		gb: RC1-BT0313-130400-016-c02 BT0313 Homo	3
441747	BE467749	Hs. 144029	ESTs, Highly similar to SOX1_HUMAN SOX-1	3
448156	AI472886		gb: tj75d01.x1 Soares_NSF_F8_9W_OT_PA_P_S	3
418298	AA256014	Hs. 86682	Homo sapiens cDNA: FLJ21578 fis, clone C	3
404196	c6p3_1867			3
452528	AA742457	Hs. 291479	ESTs	3
451540	AI801860	Hs. 208837	ESTs	3
436893	AA736815	Hs. 149225	ESTs	3
401758	c17p1_10881			3
435633	AI248152	Hs. 270047	ESTs	3
409955	U60665	Hs. 57692	testis specific basic protein	3
440600	AI807691	Hs. 126351	ESTs	3
401946	c17p3_245			3
429668	AA626142	Hs. 179991	ESTs, Weakly similar to KPCE_HUMAN PROTE	3
424562	AI420859	Hs. 150557	basic transcription element binding prot	3
402627	c1p1_26870			3
400400	AF144054	Hs. 283886	Homo sapiens apoptosis related protein A	3
413813	M96956	Hs. 75561	teratocarcinoma-derived growth factor 1	3
433851	AA610436	Hs. 196461	ESTs	3
432217	AI864415	Hs. 162157	ESTs, Moderately similar to B34087 hypot	3
454573	BE146471		gb: QV0-HT0216-011199-043-c09 HT0216 Homo	3
432304	AA932186	Hs. 164214	ESTs	3
458072	AI890347	Hs. 271923	EST	3
443633	AL031290	Hs. 9654	similar to pregnancy-associated plasma p	3
454697	AW813728	Hs. 15036	ESTs, Highly similar to AF161358 1 HSPC0	3
415877	R45135	Hs. 21026	ESTs	3
458943	AW249181	Hs. 19954	ESTs, Weakly similar to cDNA EST yk386e1	3
431775	AW205945	Hs. 27008	phosphatidylinositol glycan, class L	3
433391	T77201		gb: yc95c09.r1 Soares infant brain 1NIB H	3
411929	AA098880	Hs. 69297	ESTs	3
443728	AI083876	Hs. 148383	ESTs	3
449637	AA001964		gb: ze49e02.r1 Soares retina N2b4HR Homo	3
436857	AA732647		gb: nz89d01.s1 NCI_CGAP_GCB1 Homo sapiens	3
406562	ph2_6297			3
411484	AW848117		gb: IL3-CT0214-301299-048-D04 CT0214 Homo	3
456549	AA283740	Hs. 89211	ESTs	3
443751	AI285839	Hs. 153324	ESTs	3
428515	AF030339	Hs. 286229	plexin C1	3
415727	BE501389	Hs. 20848	ESTs, Weakly similar to U5 snRNP-specifi	3
453493	AL039478		gb: DKFZp434P0510_s1 434 (synonym: htes3)	3
429505	AW820035	Hs. 204290	Homo sapiens mRNA; cDNA DKFZp586N2119 (f	3
432741	AI732358	Hs. 185118	ESTs	3
408766	AA057270		gb: zk70c03.r1 Soares_pregnant_uterus_NbH	3
455036	AW851630		gb: MR2-CT0222-211099-002-h06 CT0222 Homo	3
421036	AA810560		gb: oa71h06.s1 NCI_CGAP_GCB1 Homo sapiens	3
416584	N63864	Hs. 205554	ESTs	3
420125	AA255739	Hs. 283332	ESTs	3
434137	AA907734	Hs. 124895	ESTs	3
402747	c1p1_7488			3
457508	AA542909	Hs. 162214	ESTs	3
444927	AW016637	Hs. 199425	ESTs	3
408443	N33937	Hs. 10336	ESTs	3
408033	AW138045	Hs. 242256	ESTs	3
425560	AA359368	Hs. 165998	DKFZP564M2423 protein	3
444531	BE158822	Hs. 282469	ESTs	3
455404	BE175503		gb: RC5-HT0580-050400-021-B01 HT0580 Homo	3
458786	AI457098	Hs. 280848	ESTs	3
447034	N49580	Hs. 46630	ESTs	3
434286	AF123758	Hs. 127675	ceroid-lipofuscinosis, neuronal 8 (epile	3
400488	c10p1_1764			3
453502	AL039786		gb: DKFZp434A0912_r1 434 (synonym: htes3)	3
406225	ph0_8239			3
424554	AA747563	Hs. 131799	ESTs, Weakly similar to ALU8_HUMAN ALU S	3
409854	AW501833		gb: UI-HF-BR0p-ajo-d-01-0-UI.r1 NIH_MGC_5	3
453006	AI362575	Hs. 167133	ESTs	3
406531	ph2_4560			3
451333	AK000914	Hs. 26244	hypothetical protein FLJ10052	3
419882	AA687313	Hs. 190043	ESTs	3
432073	AW661883	Hs. 259353	ESTs	3
426420	BE383808	Hs. 169829	KIAA1180 protein	3
437089	AA844539	Hs. 240855	ESTs	3
422638	AI474074	Hs. 172070	ESTs, Weakly similar to cAMP-specific cy	3
454754	AW819191		gb: CM1-ST0283-071299-061-d08 ST0283 Homo	3
429768	AA805719	Hs. 192154	ESTs	3
445224	BE254241	Hs. 288885	Homo sapiens cDNA FLJ14246 fis, clone OV	3
450684	AA872605	Hs. 25333	interleukin 1 receptor, type II	3
435211	AI248618	Hs. 193586	ESTs	3
419392	W28573		gb: 51f10 Human retina cDNA randomly prim	3
427624	AA406245	Hs. 24895	ESTs	3
454803	AW860148		gb: RC0-CT0379-290100-032-b10 CT0379 Homo	3
427419	NM_000200	Hs. 177888	histatin 3	3
439884	H42671		gb: yp13h12.r1 Soares breast 3NbHBst Homo	3
407438	AF227133		gb: Homo sapiens candidate taste receptor	3
427700	AA262294	Hs. 180383	dual specificity phosphatase 6	3
408602	AA055833	Hs. 58152	ESTs, Weakly similar to anagen-specific	3
405548	cNp3_24436			3
453916	AW974874	Hs. 75212	omithine decarboxylase 1	3
425611	AF012270	Hs. 158338	retinal pigment epithelium-derived rhodo	3
459238	AF053551	Hs. 31584	metaxin 2	3
454816	AW833258		gb: RC2-TT0007-131099-011-b10_1 TT0007 Ho	3
443184	AI638728	Hs. 131973	ESTs	3
407986	U32659	Hs. 41724	interleukin 17 (cytotoxic T-lymphocyte-a	3
405510	cNp3_22634			3
435118	AA665576	Hs. 116581	ESTs	3
414041	AW974100	Hs. 293265	ESTs	3
450508	R37408	Hs. 101654	ESTs	3
417699	T91491	Hs. 119670	ESTs	3
438160	AA779332	Hs. 122671	ESTs	3
423792	AW135866	Hs. 245854	ESTs	3
437208	AA236599		gb: zs42c10.r1 Soares_NhHMPu_S1 Homo sapi	3
412234	AW902641		gb: QV3-NN1024-100500-181-d08 NN1024 Homo	3
409937	AI804584	Hs. 57672	leucine rich repeat (in FLII) interactin	3
410158	AA082030		gb: zn26h08.r1 Stratagene neuroepithelium	3
408448	BE467627	Hs. 285574	ESTs	3
435308	N28276	Hs. 117087	ESTs	3
459472	AA568933		gb: nm23c07.s1 NCI_CGAP_Co10 Homo sapiens	3
430826	U10061	Hs. 248019	POU domain, class 4, transcription facto	3
403003	c21p3_2293			3
404499	c8p1_4589			3
407530	X68790		gb: H. sapiens bactericidal BPl′gene for a	3
456280	D63477	Hs. 84087	KIAA0143 protein	3
446418	AI301117	Hs. 150182	ESTs	3
420535	AA280095	Hs. 88689	ESTs	3
410815	AW805974		gb: QV1-UM0106-130400-152-b10 UM0106 Homo	3
447925	AW292271	Hs. 250718	ESTs	3
441769	R62241	Hs. 172780	ESTs	3
439889	AA848093	Hs. 192993	ESTs	3
431525	AA506656	Hs. 6185	KIAA1557 protein	3
414294	BE270795	Hs. 268864	ESTs	3
451300	AA017066	Hs. 237686	EST	3
410204	AJ243425	Hs. 738	early growth response 1	3
413939	AL047051	Hs. 199961	ESTs	3
425925	AF176813	Hs. 163045	soluble adenylyl cyclase	3
418088	R49517	Hs. 268703	ESTs	3
436681	AI288242		gb: ql80b03.x1 Soares_NhHMPu_S1 Homo sapi	3
453565	BE298808	Hs. 33363	DKFZP434N093 protein	3
420568	F09247	Hs. 167399	protocadherin alpha 5	3
444564	AI167877	Hs. 143716	ESTs	3
436317	AL096777		gb: Novel human gene mapping to chomosome	3
441299	AA927914	Hs. 223718	ESTs	3
443338	R99575		gb: yq72c01.s1 Soares fetal liver spleen	3
410286	AI739159	Hs. 61898	DKFZP586N2124 protein	3
416659	W22048		gb: 61A12 Human retina cDNA Tsp509I-cleav	3
435070	AI821270	Hs. 116930	ESTs	3
449877	BE408252	Hs. 301008	ESTs	3
401945	c17p3_241			3
452102	U04343	Hs. 27954	CD86 antigen (CD28 antigen ligand 2, B7-	3
454292	N57559	Hs. 82273	hypothetical protein	3
402718	c1p1_6495			3
441453	AW176106	Hs. 285459	ESTs, Weakly similar to unknown [D. melan	3
428785	AI015953	Hs. 125265	ESTs	3
414650	AA150435	Hs. 72063	ESTs	3
411173	R81571		gb: yj02h10.r1 Soares placenta Nb2HP Homo	3
446112	AV656599	Hs. 282636	ESTs	3
404439	c8p1_195			3
412281	AI810054	Hs. 14119	ESTs	3
432965	AW974144	Hs. 133860	ESTs	3
404632	c9p1_2941			3
459031	AA017571	Hs. 159398	ESTs	3
436195	AA774834	Hs. 75761	SFRS protein kinase 1	3
428788	AF082283	Hs. 193516	B-cell CLL/lymphoma 10	3
431512	BE270734	Hs. 2795	lactate dehydrogenase A	3
424536	AW965002	Hs. 47232	ESTs	3
443982	AI222998	Hs. 134962	ESTs	3
415120	N64464	Hs. 34950	ESTs	3
441555	AI651563	Hs. 178912	ESTs	3
419932	AA281594		gb: zt03a01.r1 NCI_CGAP_GCB1 Homo sapiens	3
422860	S67798	Hs. 121494	sperm adhesion molecule 1 (PH-20 hyaluro	3
453125	AW779544	Hs. 115497	Homo sapiens cDNA: FLJ22655 fis, clone H	3
448306	AI480270		gb: tm26d07.x1 Soares_NFL_T_GBC_S1 Homo s	3
406284	AW068311	Hs. 82582	integrin, beta-like 1 (with EGF-like rep	3
454289	AL137554	Hs. 49927	Homo sapiens mRNA; cDNA DKFZp434H1720 (f	3
403283	c2p1_4629			3
439541	AW970853		gb: EST382936 MAGE resequences, MAGK Homo	4
431124	AF284221	Hs. 59506	doublesex and mab-3 related transcriptio	4
435701	AW236397	Hs. 63131	Homo sapiens cDNA FLJ13155 fis, clone NT	4
441577	AI422096		gb: tf57h05.x1 NCI_CGAP_Brn23 Homo sapien	4
429258	AA448765		gb: zx10e09.r1 Soares_total_fetus_Nb2HF8—	4
432407	AA221036	Hs. 285026	HERV-H LTR-associating 1	4
422017	NM_003877	Hs. 110776	STAT induced STAT inhibitor-2	4
405591	cNp3_27585			4
439824	AW303556	Hs. 124515	ESTs	4
456370	AA234938	Hs. 87384	ESTs	4
413539	BE146879		gb: QV4-HT0222-261099-014-c11 HT0222 Homo	4
409894	BE081731		gb: QV2-BT0635-220400-158-e04 BT0635 Homo	4
440344	AA928516	Hs. 190575	ESTs	4
445180	BE217929	Hs. 147470	ESTs	4
421089	AB037771	Hs. 101799	KIAA1350 protein	4
414118	AI659167	Hs. 75968	thymosin, beta 4, X chromosome	4
405863	ph0_11166			4
432877	AW974111	Hs. 292477	ESTs	4
453043	AW136440	Hs. 224277	ESTs	4
443725	AW245680	Hs. 9701	growth arrest and DNA-damage-inducible,	4
411810	AW947513		gb: RC0-MT0002-140300-011-e04 MT0002 Homo	4
457807	N89812	Hs. 138809	Human clone 23564 mRNA sequence	4
444559	W04370	Hs. 282795	ESTs	4
401027	c11p1_812			4
402134	c19p1_1058			4
459646	AW883968		gb: QV3-OT0063-290300-135-c04 OT0063 Homo	4
420954	AA282074	Hs. 301753	Homo sapiens cDNA FLJ11614 fis, clone HE	4
425431	T62818	Hs. 257482	ESTs	4
446104	AI571189	Hs. 55977	Homo sapiens cDNA: FLJ20985 fis, clone C	4
410178	AA082211	Hs. 233936	myosin, light polypeptide, regulatory, n	4
441861	AA970039	Hs. 200940	ESTs	4
459045	N69101	Hs. 32703	ESTs	4
452948	AW368451	Hs. 188665	ESTs, Weakly similar to sodium-hydrogen	4
456375	AF147766	Hs. 199647	Homo sapiens cDNA FLJ12993 fis, clone NT	4
454365	AW966728	Hs. 54642	methionine adenosyltransferase II, beta	4
435864	AL036499	Hs. 188491	ESTs	4
428799	AI478619	Hs. 104677	ESTs	4
444268	AI139642	Hs. 143239	ESTs	4
457674	AF119908	Hs. 235516	hypothetical protein PRO2955	4
434628	H47495	Hs. 13810	ESTs	4
459726	AI904506		Homo sapiens cDNA: FLJ21802 fis, clone H	4
438524	AI824326	Hs. 22305	ESTs	4
411280	N50617		EST cluster (not in UniGene)	4
431317	AA502682		gb: ng23d01.s1 NCI_CGAP_Ov2 Homo sapiens	4
454148	AW732837	Hs. 42390	nasopharyngeal carcinoma susceptibility	4
431723	AW058350	Hs. 16762	Homo sapiens mRNA; cDNA DKFZp564B2062 (f	4
418922	AW956580	Hs. 42699	Thrombospondin-1 (Hs. 87409)	4
426653	AA530892	Hs. 171695	dual specificity phosphatase 1	4
458032	AW979141	Hs. 293917	Homo sapiens cDNA FLJ11774 fis, clone HE	4
412429	AV650262	Hs. 75765	GRO2 oncogene	4
421568	W85858	Hs. 99804	ESTs, Weakly similar to ALU1_HUMAN ALU S	4
413919	BE180590		gb: RC3-HT0625-130400-021-d12 HT0625 Homo	4
413576	BE149684		gb: RC1-HT0256-280300-017-d10 HT0256 Homo	4
454204	AW816498		gb: QV0-ST0236-171299-075-b02 ST0236 Homo	4
433712	AF090887		gb: Homo sapiens clone HQ0085	4
445832	AI261545		gb: qz30a07.x1 NCI_CGAP_Kid11 Homo sapien	4
404432	c8p1_1658			4
432745	AI821926	Hs. 269507	ESTs	4
405763	cXp3_1388			4
416843	D45467	Hs. 58606	ESTs	4
427608	BE148596	Hs. 179779	ribosomal protein L37	4
450594	N31036		gb: yx51g04.r1 Soares melanocyte 2NbHM Ho	4
427366	AA885108	Hs. 223806	Homo sapiens cDNA: FLJ23157 fis, clone L	4
445772	AI733941	Hs. 145493	ESTs, Weakly similar to ALU7_HUMAN ALU S	4
404485	c8p1_4167			4
442621	AI004333	Hs. 130553	ESTs, Weakly similar to ALUA_HUMAN !!!!	4
410255	AA234006	Hs. 190488	hypothetical protein FLJ10120	4
421358	AA806749	Hs. 290346	ESTs	4
416708	H78836		gb: yu09a06.r1 Soares fetal liver spleen	4
453434	AJ271378	Hs. 140951	ESTs	4
426946	AA393595	Hs. 97446	ESTs	4
446087	AI298072	Hs. 149441	ESTs	4
453816	AL135405		gb: DKFZp762K1015_r1 762 (synonym: hmel2)	4
448588	AI970276	Hs. 156905	ESTs	4
450775	AA902384	Hs. 110248	ESTs	4
416107	AA173846	Hs. 79015	antigen identified by monoclonal antibod	4
422766	AA334108	Hs. 159572	heparan sulfate (glucosamine) 3-O-sulfot	4
454991	AW850163		gb: IL3-CT0219-271099-022-D02 CT0219 Homo	4
407528	X64990		gb: H. sapiens mRNA HTPCRX16 for olfactory	4
441910	AI150328	Hs. 226402	ESTs, Weakly similar to mitochondrial ci	4
450438	AI696071	Hs. 253800	ESTs	4
430251	AA609246	Hs. 181451	ESTs	4
440358	AW296778	Hs. 300357	ESTs, Highly similar to dJ416F21.2 [H.sa	4
409236	BE539805		gb: 601061906F1 NIH_MGC_10 Homo sapiens c	4
449335	AW150717	Hs. 296176	STAT induced STAT inhibitor 3	4
404099	c6p1_1419			4
418214	AA215293	Hs. 156004	ESTs	4
406108	ph0_2356			4
441492	AI149998	Hs. 146346	ESTs	4
458867	AW995393		gb: QV0-BN0042-170300-163-g12 BN0042 Homo	4
447283	BE061049	Hs. 258396	ESTs	4
401514	AF147186		gb: AF147186 Homo sapiens library (Schere	4
428263	AA424811	Hs. 152155	ESTs	4
434970	AW272262	Hs. 250468	ESTs	4
440882	AI205777	Hs. 129538	ESTs	4
405099	cNp1_23324			4
458960	BE383204		gb: 601298758F1 NIH_MGC_19 Homo sapiens c	4
453611	BE009728		gb: PM0-BN0173-120400-001-f09 BN0173 Homo	4
447605	AW504937	Hs. 211169	ESTs	4
436819	AA731746	Hs. 120232	ESTs	4
419134	T89863	Hs. 221771	ESTs	4
403159	c2p1_1584			4
456973	AA375710	Hs. 102746	ESTs	4
401454	c14p3_4909			4
412625	AA114946	Hs. 261314	ESTs	4
417551	AI816291	Hs. 82273	hypothetical protein	4
440962	AI989961	Hs. 233477	ESTs, Moderately similar to A Chain A, S	4
423291	NM_004129	Hs. 126590	guanylate cyclase 1, soluble, beta 2	5
417977	AA210787	Hs. 243748	ESTs	5
456667	AW665591	Hs. 114658	ESTs	5
402337	c19p3_4189			5
451838	AW005866	Hs. 193969	ESTs	5
406346	ph2_13138			5
404121	c6p1_3615			5
446698	AW451812	Hs. 202503	ESTs	5
444988	AF272830	Hs. 12229	Homo sapiens cDNA FLJ11324 fis, clone PL	5
418443	NM_005239	Hs. 85146	v-ets avian erythroblastosis virus E26 o	5
457993	AI799102	Hs. 292732	ESTs, Weakly similar to Gab2 [H. sapiens]	5
446546	BE167687	Hs. 156628	ESTs	5
435917	AA702143	Hs. 190365	ESTs	5
413496	BE144841		gb: CM0-HT0181-181099-075-f10 HT0181 Homo	5
403661	c3p3_219			5
421177	AW070211	Hs. 102415	Homo sapiens mRNA; cDNA DKFZp586N0121 (f	5
459660	M79082		ESTs	5
411708	AW857808		gb: RC4-CT0322-261299-011-c02 CT0322 Homo	5
411962	AA099050		gb: zk85d12.r1 Soares_pregnant_uterus_NbH	5
426087	M61877	Hs. 1985	spectrin. alpha, erythrocytic 1 (ellipto	5
416188	BE157260	Hs. 79070	v-myc avian myelocytomatosis viral oncog	5
458410	H20380	Hs. 200250	ESTs, Weakly similar to neuronal thread	5
405387	cNp3_16477			5
457873	AA736920	Hs. 288518	ESTs	5
453511	AL031224	Hs. 33102	transcription factor AP-2 beta (activati	5
438863	R38002		gb: yh97g12.r1 Soares placenta Nb2HP Homo	5
458467	AW747996	Hs. 160999	ESTs	5
447844	AI433873	Hs. 35085	ESTs	5
438675	AA813725	Hs. 213568	ESTs	5
439170	AA332365	Hs. 165539	ESTs	5
410483	BE163567		gb: QV3-HT0460-230200-101-b08 HT0460 Homo	5
401276	c13p1_293			5
430725	AA485056	Hs. 173692	ESTs	5
449834	AL161980	Hs. 24022	Homo sapiens mRNA; cDNA DKFZp761H1023 (f	5
400827	c11p1_19707			5
425534	AA995635	Hs. 7589	ESTs	5
416493	H60593	Hs. 124990	ESTs	5
434977	AI734233	Hs. 226142	ESTs, Weakly similar to ALU7_HUMAN ALU S	5
456466	AA700127	Hs. 190504	ESTs	5
458489	AI142274	Hs. 145423	ESTs	5
433232	AI658621	Hs. 127769	ESTs	5
420270	AA257990		gb: zs35h07.r1 NcI_CGAP_GCB1 Homo sapiens	5
454410	AW812744		gb: RC3-ST0186-181099-012-c09 ST0186 Homo	5
420431	AB007131	Hs. 97624	heat shock transcription factor 2 bindin	5
400844	c11p1_20936			5
435517	AA928626	Hs. 130177	ESTs	5
412996	BE046224		gb: hn38c12.x2 NCI_CGAP_RDF2 Homo sapiens	5
420475	AW408407	Hs. 187018	ESTs	5
421126	M74587	Hs. 102122	insulin-like growth factor binding prote	5
430269	BE221682	Hs. 178364	ESTs	5
425673	R70318		gb: yj81a09.r1 Soares breast 2NbHBst Homo	5
435057	AW291345	Hs. 254970	ESTs	5
405667	cNp3_6851			5
402527	c1p1_18184			6
459407	N92114		gb: za22h11.r1 Soares fetal liver spleen	6
454302	AA306105	Hs. 50785	SEC22, vesicle trafficking protein (S. c	6
426436	AA378512	Hs. 287639	Homo sapiens cDNA FLJ14334 fis, clone PL	6
412791	AI131192	Hs. 143199	ESTs	6
441189	AW450266	Hs. 257276	ESTs	6
456013	T92048		gb: yd54g12.s1 Soares fetal liver spleen	6
441698	BE299588	Hs. 28465	Homo sapiens cDNA: FLJ21869 fis, clone H	6
438597	AA811662	Hs. 171497	ESTs	6
456592	R91600		gb: yq10c02.r1 Soares fetal liver spleen	6
402312	c19p3_3548			6
418912	NM_000685	Hs. 89472	angiotensin receptor 1	6
440700	AW952281	Hs. 296184	ESTs, Highly similar to GB01_HUMAN GUANI	6
424128	AW966163		gb: EST378236 MAGE resequences, MAGI Homo	7
419711	C02621	Hs. 159282	ESTs	7
444851	AL117425	Hs. 301413	Homo sapiens cDNA FLJ11516 fis, clone HE	7
414137	BE220829	Hs. 50652	ESTs, Moderately similar toALU1_HUMAN A	7
401438	c14p3_401			7
457656	AA625087	Hs. 224405	ESTs	7
434402	AA745143	Hs. 212498	ESTs	7
413574	BE149158	Hs. 129998	Homo sapiens cDNA FLJ14267 fis, clone PL	8
447317	BE312948	Hs. 18104	hypothetical protein FLJ11274	8
444698	AI188139	Hs. 147050	ESTs	12
430758	T91568	Hs. 270616	ESTs, Moderately similar to A34087 hypot	12
452049	BE268289	Hs. 27693	CGI-124 protein	19
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Title: Gene title
R1: Non-diseased liver: Diseased Liver

[0339]

TABLE 2B
451400	1103195_1	BE069211 BE160479 BE160478 AI793147 AW861059
415328	1870242_1	Z44310 R55952 F05790
408834	717496_1	AW276241 BE167263 BE167259
455806	1515155_1	BE141094 BE141097 BE141263 BE141118 BE141253 BE141256 BE141225 BE141092 BE141124 BE141248 BE141254
		BE141262 BE141093
		BE141115 BE141259 BE141255 BE141226 BE141213 BE141222 BE141128 BE141129 BE141211 BE141157
		BE141257 BE141258 BE141250
		BE141116 BE141208 BE141227 BE141096 BE141112 BE141261 BE141121 BE141120 BE141300 BE141111
		BE141117 BE141131 BE141212
		BE141223 BE141090
455181	1106814_1	BE161696 AW863568 BE161629 BE161824
423167	879906_1	BG995664 AA322711 D79268 AA770464
459263	2049982_1	AJ003496 AJ003505 L25475
455175	1103799_1	AW993247 AW861464
454448	1028414_1	BE073941 BE073901 AW750209
409113	49403_1	AF319957 AA113914 AA131489 AA113889 AA075684 AA071047 AA126078 AA126283 AA075895 AA074583
		AA070580 AA131372 AA079230
		AA148748 AA120938 AA079200 AA122355 AA075041 AA071086 AA071110 AA074485 AA076151 AA070940 AA071308
		AA070627 AA076622
		AA079623 AA078802 AA079143 AA085188 AA079434 AA075968 AA071453 AA074159 AA076131 AA079401 AA115163
		AA079329 AA069053
		AA101144 AA070053 AA071087 AA102076 AA071310 AA122204 AA079659 AA063317 AA148628 AA078803 AA121103
		AA076187 AA078931
		AA070156 AA074198 AA070928 AA127089 AA083070 AA079280 AA134725 AA126185 AA076056 AA078833 AA084710
		AA079117 AA084027
		AA075042 AA129030 AA068994 AA069817 AA074897 AA079208 AA085044 AA081472 AA069220 AA071430 AA085118
		AA083166 AA079450
		AA074563 AA065051 AA100188 AA115929 AA064871 AA129031
459689	1272662_1	AA347192
439034	52270_1	AF075083 H52291 H52528
415350	1870780_1	T80268 R18726 Z44987 F12665 F11445 F11572 F06404 T74313 R13218 R13622
459695	817414_1	AW963571 AA381579 BG547915 H69131
455195	1107903_1	AW864319 AW864370 AW864504
411861	223814_1	BE067343 AW867875 BE067301 BE067347 BE067303 BE067304 BF851070 BE067350 BE067305 BE067306
		BE067302 AW938147
456576	267535_1	AA287443 AI478347 AA419385 BE084078
454442	44916_2	AL529783 BF804681 BI858809 AW748795 AW816134 BE063456 BI911312 BG615273 AA347409
454520	825_6	BC020822 AW803378 AW803435 AW803371 BI518461 AV762185 AA298048 BI521095 AV764359 AV760834
		BG548457 BI911189
459349	1027822_1	AW749381 H93337
455104	1096744_1	BF330730 BF350539 BE153665 BE065062 BE064650 BE064863 BF330763 BE153820 BE064737 BE155079
		BE064651 AW856751 AW856622
		BE064691 BE153674 BE153698 BE064730 BE153536
424200	890908_1	AW966196 AA337221 AA336756
423290	7964_7	AJ295991 AU138209 AV649543 BG195745 BG208133 AI458145 AW183395 AV649405 BF950906 AW962011
		AW902934 AA324130 BI753806
449305	1066708_1	AW813561 AI638293
413257	1497012_1	BE075035 BE074999 BE075006 BE075008 BE075005 BE075032 BE075037
430692	60836_7	AI133594 AI064750 AW328184
424686	1228447_1	AW963243 AA345251 AA345504
411658	1095903_1	AW855645 AW855615 AW855610 BE148763 BE148764 BG951004 BG950922 BG950984 BG950998 BG950924
		BG950921 BG951005 BG950995
		BG950988 BG950919 AW855605 AW855608 BG950991 AW855598 AW855601 AW855596 BG950985
459721	36709_2	BE256910 AI299050 BG471673
442484	3699_10	AI110863 AF075362 AI110861 AF075360
411689	1097490_1	AW857121 AW861238 AW857123
411902	1141058_1	AW875344 AW875287 AW875285 AW875286 BF361295 AW875402 AW875400
418225	1239780_1	AW976061 AA747676 AA214595
410900	1063481_1	AW810169 AW809654 AW809839 AW810090 AW809703 AW809891 BF374636 BF374628 BF374725 AW810616
		AW809733 BF374640 BF374623
		AW810564
449986	2292_10	AK055879 AW007836 AA873089 N74374 AV720071 AA702706 AW055276 BE672779 AW864502 AI678780 AW864369
		AI052145 T40984 N74426
413088	1489839_1	BE064856 BE064853 BE064960 BE064962 BE064857 BE064977 BE064860 BE064850 BE064815 BE064816
		BE064806 BE064818 BE064796
		BE064804 BE064668 BE064810 BE064979 BE064957 BE064819 BE064975 BE065059
448156	515877_1	BI495496 AW023207 BI495497 AI472886 AW023239
454573	22511_7	AW833609 AW833743 BI035140 AW821469 AW821541 AW821488 AW821531 AW821384 AW821625 AW821547
		AW821549 AW821513
		AW821577 BI034572 BI034365
433391	16854_1	AF038194 BG431979 BF987851 R52301 T77201
449637	34908_4	AL558074 BI914921 AV747407 AV749215 AA001964
436857	448721_1	AA732647 BE009028 BE008970
411484	1085933_1	AW848117 AW848128 AW848278 AW848401 AW848405 AW848281 AW848763
453493	470764_1	AL039478 AW970882
408766	106215_1	BG028106 BE155008 BE155007 AA057270 AA058715
455036	1091116_1	AW851708 AW851735 AW851703 AW851630 AW851712 AW851723
421036	264886_1	AW977543 AA282918
455404	703567_1	BE175503 BE175583 AW936409 AW936404
453502	1668_5	AF332192 NM_032491 BG772831 BG772873 BI460034 BI560011 BG723202 BG701021 BG720172 BI826825
		BI464806 BG723004 BI559763
		BI460842 BG773364 BI460208 BF377004 AL042201 BE855589 BE857075 AL044045 AA906504 AA961631
		AW899993 AA885061 AW900006
		AI652619 AI002078 AA983818 BG152590 BE763010 Z38801 F04136 F02320 H17003 BE762943 AI191585 N66165
		BE762995 Z40423 AL039786
		BI559354 BI562672 BG718512 BG720380 BI458642 BG772693 BI561299 BI459216 BF933814 R13208 Z42633 F07285
		H10144 Z42852 F07873
		R35183 H17002 F07362 BI459457 AL041856 BG724404 BG718143 BG701878 R50843 H10145 R40295 AW592045
		BE935655 BG771671
409854	916262_1	AW502145 AW501833 AW502581
454754	1070974_1	AW819177 AW819242 AW819191 AW819175 AW819252 AW819244 AW819265 AW819269 AW819190
		AW819268 AW819183 AW819246
		AW819194 AW819249 AW819186 AW819180 AW819188 BE158470 AW819251 BE152602 AW819263
419392	215562_2	W28573 W27418
454803	1072913_1	BI468492 AW862380 AW860148 AW821887 AW821863 AW821894 AW821870 AW862378 AW862351
439884	10759_1	AB051476 BG289143 AV753375 AW051603 AW294678 AI435358 AI357776 AI091413 AI435427 AI367010 AI538999
		AI039731 N67220 AW119213
		BE326750 AI369016 T16459 R55315 AW296026 AI553628 AI537645 AI923565 BE910660 AW237341 H42671
		H09709 AA847991 AA355842
		BM454895 Z46035 AW195056 D63011 AI765593 BF999411 R55417 N91158 H88285 H99837 H49679 D61792
		H52824 AW603615 R33635
		D29082
454816	1073598_1	AW833298 AW833294 AW833272 AW833271 AW833274 AW833308 AW833275 AW833296 AW833295
		AW833258 AW833306
437208	28382_1	AL110259 AA236599
412234	1160035_1	AW902569 AW902557 AW902654 AW902641 AW902650 AW902741 AW902644
410158	114375_1	BI256712 BF327164 AW936396 AW936458 AW936418 BF380035 BF368137
459472	1095076_1	AW854431 AA568933
410815	3326_23	AW805981 AW805974 AW806135 AW805972
436681	6833_1	AK021878 AU119692 AW502159 AU145969 AI393268 BE939969 AI288242 AI051978 BE677884 AI436745
		AI935582 AI686473 AW861386
		AA725270 BE940025 BF829279
436317	3614_2	AL096777 BM457842 AU116901 NM_021946 AK021424 AU158712 BE328021 BF765194 BF804830 BE621537 AA968672
443338	2262575_1	R99575 AI052252 R99681
416659	290122_1	W22048 W19418 H72518 BF908045
411173	881247_1	AW962014 AA324277 BI022237 AA091723 R81571
419932	3433_3	BI766402 AI365043 AA251996 N46090 AA281594
448306	50570_1	AK057289 AL601840 AL602227 BE247000 AA417150 BM150327 BM151615 BE247403 BE245780 AI480270
		BE246663 BE245079 H54482
		AI004637 T97117 AU157626 BE243570 AA781826 AA418396 H82937
439541	1235485_1	AW970853 N22817 AA837349
441577	17241_1	AK055721 AA399241 AI204074 AW269179 AI150462 AI422096 AA938959 AA024620 AA024498 AI751426
429258	121944_1	BG250865 AA448765 AA658293 C04967 BG988507 BG746352 C03045
413539	1519622_1	BE146879 BE146914 BE146918
409894	919627_1	AW503629 AW861738 BE081731 BE081969
411810	1107901_1	AW947513 AW864536 AW864318
459646	154497_1	AW470813 H44995 AW883968 BF746199 BF746344 BF746274 BF511374
459726	15924_1	NM_024644 AK025455 BC011350 AI240194 AA576870 AW295198 AW262665 AA968435 AA815311 AW769847
		AA100496 AI796246 BI257802
		AI968266 BF447872 AW341239 BE674505 AI183838 BF221583 Z40969 N64168 AI904509 AI904506 BG610839
		BG107618 BG108325 BE784665
		BE389806 BE390268 BF000100 AW444473 BF194857 BE843654 AW449497 BE093686 AL523620 AW402647
		BI753888 BI913225 BM040984
		Z45254 BF794833 BI915966 BI831226 AL523619 BG991161 BG957808 BE895148 BG469054
411280	1610_5	BF527858 AV713798 N50617 N47321 BF871615 R54159 BF741988 BF741990 BF741989 AW860545 AW835317
431317	997174_1	AW970601 AW613399 AA503435 AA502682 N91138
413919	1565718_1	BE180590 BE180585 BE180594
413576	417218_1	BG535869 BM263801 AV703254 T39786 BM263489 BE149684 T39845
454204	646158_1	AW816498 BF374419 BF374408 BF374405 AW808977 AW808605 BF334681 BF348941 BF348944 AW178676 BF374412
		AW178486 BF374427
		BF374429 BF348942 BF374428 BF348955 BF348940 BF348943 BF374416 BF374424 BF374431 BF374430 AW808524
		BF374413 BF374418
		BF334708 BF374389 BF334685 BF374473 BF374392 BF374397 BF374395 BF374407 BF374417 BF374420 BF374414
		BF374422 BF374421
		BF374522 BF349306 AW808532 BF374399 BF374393 BF374398 BF374394 BF374396 AW178485 BF374391
		AW808816 BF374516 AW178483
		AW808515 AW808791 BF374390 BF374415 AW808514 AW808379 BF374423 BF374426 BF348949 AW809007
433712	77122_3	AF090887 AI110655 AF063529
445832	437253_1	BF116098 AI261545 AW875247 N59134 AW875371
450594	82197_1	N31036 N42915 F07753 AA010329
416708	309677_1	R07686 T95204 T95230 H78836 BF932909
453816	9500_19	BG107738 BE149281 AL135405 AW891435
454991	1088900_1	AW850659 AW850532 AW850667 BE143543 AW850163 BF367228 AW850661
409236	777089_1	BE539805 BE536062 AW368376
458867	1246993_1	AW995393 AJ403118
458960	50855_1	NM_024331 BC003071 BM012414 BE315221 BG750119 BE272198 AL449476 BE886722 AI360302 BG002949
		BM454474 AL449598 BM012506
		BE383204 AA010225 AL449685 AL449684 BF742320 T06328
453611	1477969_1	AL045316 BF009728
413496	1517996_1	BE144708 BE144844 BE144705 BE144828 BE144815 BE144701 BE144841 BF144823 BE144836
459660	25501_86	BE072622 M79082
411708	1098544_1	AW857808 AW857817 AW857833 AW857837 AW857873
411962	2307710_1	AA099050 AA099526 T47733
438863	52130_1	AF075004 BF109017 R38002 R38003 F22027
410483	1028391_1	BE073747 AW750178 BE163567 BE073739 BE073748 BE073780 BE163491 BE163495 BE073763 BE073671
		BE073689 BE073769
420270	258327_1	AW816460 AA257990 AI416981 AW500873
454410	6852_9	AW812744 AW581974 BG985054 AW812725
412996	1343199_1	BE046224 BE046730 BE046302
425673	727129_1	BG697146 AA361514 AW957439 AW298175 BI495720 R70319 AA579358 AI798179 AI633067 BG743245
		AW403725 T49604 R70318
459407	1990083_1	H82757 N92114
456013	46281_8	BC015430 BG033733 T92048
456592	268841_1	AA291455 R91600 T87079
424128	890041_1	AW966163 AA335983 AA335973 AA336011 AA335668
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0340]

TABLE 2C
Pkey	Ref	strand	Nt_position
404839	7109502	Minus	11386-11689
400959	7705148	Minus	129453-130097
403397	9438368	Minus	84481-84655
404723	9884767	Minus	22795-22968
404398	9802820	Minus	17421-17497, 26796-26954,
			30866-30974
405475	1931025	Plus	1548-1702
404498	8151654	Plus	13292-13497
401074	3687273	Plus	72667-72812
401887	7229981	Plus	93973-94120
406547	7711513	Minus	172780-174358
402468	9797107	Minus	23969-24933
405278	6139075	Minus	3863-3965, 4823-4891, 5439-5529,
			6043-6170
405456	7656676	Plus	150052-150208
404319	9211467	Plus	54436-54608
403600	8101279	Minus	3680-3838
401775	9966311	Minus	110228-110340
405532	9755485	Minus	37485-39417
401411	7799787	Minus	144144-144329
403212	7630897	Minus	156037-156210
404834	6911603	Minus	37948-38226
401866	8018106	Plus	73126-73623
401558	7139678	Plus	103510-104090
405698	4165331	Plus	54114-54225
404974	3241949	Minus	12524-13612
404196	3805917	Minus	67928-68109
401758	9910067	Minus	146471-147987
401946	4914397	Plus	85670-85752, 86415-86571,
			87635-87796, 8791
402627	9931216	Plus	12136-12272, 16487-16628,
			17654-17798, 1849
406562	7711584	Plus	37316-37426
402747	9212492	Minus	7105-7357
400488	8919452	Plus	97365-98784
406225	7417725	Minus	9581-10055
406531	7711474	Minus	20515-20648, 22519-22601
405548	1532158	Plus	11552-11686
405510	7630909	Minus	101028-101174
403003	5441423	Minus	79403-79560, 79712-80021
404499	8151657	Plus	19376-19909
401945	4914397	Plus	83342-83809
402718	8969253	Plus	102033-102302, 103219-103485
404439	7139680	Plus	55316-55585
404632	9796668	Plus	45096-45229
403283	8076905	Minus	71124-71996
405591	6960456	Plus	146384-146641, 147035-147160
405863	7657810	Plus	49410-49620
401027	7230983	Minus	70407-70554, 71060-71160
402134	7704979	Minus	108621-109936
404432	7407979	Minus	123536-123660
405763	5931935	Plus	274920-275019, 276641-276802
404485	8096921	Plus	75166-75264, 124036-124232
404099	8076888	Minus	127375-127477
406108	7107999	Plus	89468-89674
401514	7622355	Plus	93224-93292, 94913-95065,
			95163-95334
405099	8074292	Minus	114365-114514, 128635-128831
403159	7408087	Plus	2775-2977
401454	9186923	Minus	114659-114832
402337	6957691	Plus	4116-4286, 16811-16973,
			17107-17256, 19715-
406346	9255974	Plus	104359-104542
404121	9796219	Plus	59256-59401
403661	8705027	Minus	30268-30482
405387	6587915	Minus	3769-3833, 5708-5895
401276	8954274	Minus	15919-16096
400827	8570385	Plus	143937-144450
400844	9188605	Plus	24746-24872, 25035-25204
405667	4726099	Plus	5798-5914
402527	9800806	Plus	4722-4916, 17858-18037,
			19964-20140, 24423-
402312	7341442	Plus	143645-143727, 147428-147514
401438	4885691	Minus	72461-72605
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0341] Tables 3A to 6C [see 60/366,782].

[0342] Table 3A lists about 1389 genes up-regulated in Hepatitis C positive liver tissues compared to Hepatitis C negative liver tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wicoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of Hepatitis C positive liver tissues to the “weighted average” of Hepatitis C negative liver tissues was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the Hepatitis C positive liver tissues was set to the trimean of various different Hepatitis C positive liver tissues. The “weighted average” of the Hepatitis C negative liver tissues was set to the either 10 or the trimean of various different Hepatitis C negative liver tissues, whichever value was greater to eliminate ratios with a denominator of zero or less.

TABLE 3A
ABOUT 1389 GENES UP-REGULATED IN HEPATITIS C POSITIVE LIVER TISSUES
COMPARED TO HEPATITIS C NEGATIVE LIVER TISSUES
Pkey	ExAccn	UnigeneID	Unigene Title	R1	R2	R3
428227	AA321649	Hs. 2248	small inducible cytokine subfamily B (Cy	5.544E−08	25.27	278.25
414004	AA737033	Hs. 7155	ESTs, Moderately similar to 2115357A TYK	1.131E−07	24.52	252.25
417621	AV654694	Hs. 82316	interferon-induced, hepatitis C-associat	8.497E−08	23.13	243
422746	NM_004484	Hs. 119651	glypican 3	8.647E−07	22.55	255.75
426711	AA383471	Hs. 343800	conserved gene amplified in osteosarcoma	5.544E−08	20.97	224.5
433854	AA610649	Hs. 333239	ESTs	1.322E−05	19.88	191
424090	X99699	Hs. 139262	XIAP associated factor-1	9.289E−06	17.80	190
448111	AA053486	Hs. 20315	interferon-induced protein with tetratri	2.262E−07	15.74	224.75
451652	AA018968	Hs. 133536	ESTs	1.321E−05	15.05	149.25
427283	AL119796	Hs. 174185	ectonucleotide pyrophosphatase/phosphodi	1.646E−06	14.90	189.75
418216	AA662240	Hs. 283099	AF15q14 protein	1.494E−07	14.17	153.25
432094	AI658580	Hs. 61426	Homo sapiens mesenchymal stem cell prote	1.322E−05	13.72	128.25
425787	AA363867	Hs. 155029	ESTs	5.734E−06	13.57	151.75
430200	BE613337	Hs. 234896	geminin	1.492E−07	13.25	122.5
446094	AK001760	Hs. 13801	KIAA1685 protein	5.391E−06	12.90	138.5
413670	AB000115	Hs. 75470	hypothetical protein, expressed in osteo	3.643E−07	12.25	211
450937	R49131	Hs. 26267	ATP-dependant interferon response protei	8.647E−07	12.07	117
442048	AA974603		gb: op34f05.s1 Soares_NFL_T_GBC_S1 Homo s	1.481E−05	11.92	115
408393	AW015318	Hs. 23165	ESTs	2.127E−06	11.82	130.75
415443	T07353	Hs. 7948	ESTs	2.129E−04	11.80	115.75
417308	H60720	Hs. 81892	KIAA0101 gene product	6.467E−06	11.70	118.75
416206	AW206248	Hs. 111092	hypothetical protein FLJ22332	5.441E−07	11.35	135.25
432378	AI493046	Hs. 146133	ESTs	1.450E−06	11.13	107.5
445823	AI478563	Hs. 145519	FKSG87 protein	3.961E−06	11.00	101.25
447973	AB011169	Hs. 20141	similar to S. cerevisiae SSM4	2.487E−05	10.97	99.75
409153	W03754	Hs. 50813	hypothetical protein FLJ20022	2.972E−07	10.72	118.75
414052	AW578849	Hs. 283552	ESTs, Weakly similar to unnamed protein	8.090E−07	10.45	142.25
409231	AA446644	Hs. 692	GA733-2 antigen; epithelial glycoprotein	1.871E−05	10.30	130.75
407347	AA829847		gb: od40d07.s1 NCI_CGAP_GCB1 Homo sapiens	2.904E−06	10.05	93
403790			NM_001334*: Homo sapiens cathepsin O (CTS	1.765E−03	9.65	103.25
450293	N36754	Hs. 171118	hypothetical protein FLJ00026	7.923E−05	9.56	117.75
421057	T58283		Homo sapiens cDNA: FLJ22063 fis, clone H	2.601E−03	9.27	85
428065	AI634046	Hs. 157313	ESTs	6.525E−04	9.22	93.25
418318	U47732	Hs. 84072	transmembrane 4 superfamily member 3	9.302E−05	9.21	115
451752	AB032997	Hs. 26966	KIAA1171 protein	6.383E−08	9.20	112.75
444665	BE613126	Hs. 47783	B aggressive lymphoma gene	1.641E−06	9.17	82.25
435812	AA700439	Hs. 188490	ESTs	2.485E−05	9.13	101.75
418143	AA283057	Hs. 266957	hypothetical protein FLJ14281	2.732E−04	9.00	82.5
435665	AI248952	Hs. 12320	ESTs	9.212E−07	8.85	103
421282	AA286914	Hs. 183299	ESTs	3.862E−04	8.67	102.5
426793	X89887	Hs. 172350	HIR (histone cell cycle regulation defec	1.083E−03	8.63	86.25
407644	D16815	Hs. 37288	nuclear receptor subfamily 1, group D, m	2.737E−04	8.56	115.25
422546	AB007969	Hs. 301478	KIAA0500 protein	2.408E−06	8.52	81.25
429490	AI971131	Hs. 23889	ESTs, Weakly similar to ALU7_HUMAN ALU S	2.951E−05	8.50	117
442994	AI026718	Hs. 16954	ESTs	5.152E−04	8.47	93.25
416224	NM_02902	Hs. 79088	reticulocalbin 2, EF-hand calcium bindin	7.048E−07	8.45	90.75
405102			C15001220*: gi|4469558|gb|AAD21311.1|(AF	1.038E−03	8.20	84.5
444314	AI140497		gb: ow76b09.s1 Soares_fetal_liver_spleen—	4.679E−04	8.10	81.25
426818	AA554827	Hs. 340046	DKFZp434A0131 protein	1.358E−03	8.02	86.5
417933	X02308	Hs. 82962	thymidylate synthetase	6.228E−04	7.95	73
432954	AI076345	Hs. 214199	ESTs	1.567E−04	7.88	76.5
449541	AA730673	Hs. 188634	ESTs	3.295E−05	7.85	70
410315	AI638871	Hs. 17625	Homo sapiens cDNA: FLJ22524 fis, clone H	1.985E−06	7.80	86
446619	AU076643	Hs. 313	secreted phosphoprotein 1 (osteopontin,	3.481E−03	7.80	83.25
433586	T85301	Hs. 194397	gb: yd78d06.s1 Soares fetal liver spleen	1.417E−03	7.80	75
436995	AI160015	Hs. 118112	ESTs	3.858E−04	7.80	71
437374	AL359571	Hs. 44054	ninein (GSK3B interacting protein)	9.840E−06	7.70	77
421904	BE143533	Hs. 109309	hypothetical protein FLJ20035	2.972E−07	7.67	130.5
442679	R53718	Hs. 107882	hypothetical protein FLJ10659	1.048E−06	7.65	113
433401	AF039698	Hs. 284217	serologically defined colon cancer antig	1.113E−06	7.55	83
435571	AF212225	Hs. 283693	mitochondrial ribosomal protein L1	1.315E−05	7.55	79.25
419175	AW270037	Hs. 179507	KIAA0779 protein	7.276E−06	7.50	65
407930	AA045847	Hs. 188361	Homo sapiens cDNA FLJ12807 fis, clone NT	5.420E−05	7.47	92.25
434263	N34895	Hs. 44648	ESTs	2.099E−03	7.47	67.5
448481	W15284	Hs. 74832	ESTs	7.876E−04	7.45	66.25
449935	AA004798	Hs. 108311	ESTs, Weakly similar to T00351 hypotheti	7.510E−05	7.38	79
407949	W21874	Hs. 247057	ESTs, Weakly similar to 2109260A B cell	7.276E−06	7.34	126.75
435102	AW899053	Hs. 76917	F-box only protein 8	6.222E−04	7.32	75.25
418452	BE379749	Hs. 85201	C-type (calcium dependent, carbohydrate-	2.417E−07	7.32	99.5
425053	AF046024	Hs. 154320	ubiquitin-activating enzyme E1C (homolog	7.505E−05	7.30	73.75
436090	AI640635	Hs. 332879	EST	6.091E−03	7.29	81.75
458725	AW970192	Hs. 171942	ras responsive element binding protein 1	6.048E−05	7.25	92.25
446488	AB037782	Hs. 15119	KIAA1361 protein	2.738E−04	7.25	88.25
449718	AA459480	Hs. 23956	hypothetical protein FLJ20502	1.994E−06	7.17	86
418840	AI821614	Hs. 185831	ESTs	5.649E−03	7.10	72.75
408063	BE086548	Hs. 42346	calcineurin-binding protein calsarcin-1	4.354E−05	7.05	100.5
436024	AI800041	Hs. 190555	ESTs	4.030E−04	7.02	72.75
447574	AF162666	Hs. 18895	tousled-like kinase 1	3.903E−05	6.97	88.75
447809	AW207605	Hs. 164230	ESTs, Highly similar to JC7266 3′,5′-cyc	1.547E−06	6.97	87
424878	H57111	Hs. 221132	ESTs	2.240E−04	6.95	105.25
450016	AA249590	Hs. 100748	ESTs, Weakly similar to A28996 prolinE-r	8.224E−06	6.90	63.75
452744	AI267652	Hs. 246107	Homo sapiens mRNA; cDNA DKFZp434E082 (fr	1.969E−07	6.82	237
433230	AW136134	Hs. 220277	ESTs	1.176E−05	6.80	99.75
409052	AW898179	Hs. 50123	zinc finger protein 189	3.075E−03	6.80	59.75
434280	BE005398		gb: CM1-BN0116-150400-189-h02 BN0116 Homo	1.650E−04	6.79	81
419586	AI088485	Hs. 144759	ESTs, Weakly similar to I38022 hypotheti	5.435E−07	6.77	76.25
422506	R20909	Hs. 300741	sorcin	1.488E−02	6.77	70.75
424941	AA128376	Hs. 153884	ATP binding protein associated with cell	5.724E−05	6.77	62
411605	AW006831	Hs. 145409	ESTs	2.596E−03	6.76	89.25
433208	AW002834	Hs. 24095	ESTs	7.123E−03	6.75	65.5
433730	AK002135	Hs. 3542	hypothetical protein FLJ11273	9.472E−04	6.72	86.5
445929	AI089660	Hs. 323401	dpy-30-like protein	1.828E−04	6.72	74.75
448694	AA478756	Hs. 194477	E3 ubiquitin ligase SMURF2	1.210E−04	6.71	88.5
446667	BE161878	Hs. 224805	ESTs	4.102E−03	6.70	64.25
452973	H88409	Hs. 93788	ESTs	9.463E−04	6.70	63.25
405268			ENSP00000223174*: KIAA0783 PROTEIN.	1.274E−04	6.70	60
423732	AF058056	Hs. 132183	solute carrier family 16 (monocarboxylic	4.464E−04	6.67	64
431214	AA294921	Hs. 348024	v-ral simian leukemia viral oncogene horn	2.707E−03	6.67	65.25
419407	AW410377	Hs. 41502	hypothetical protein FLJ21276	2.125E−06	6.60	103.75
422040	AA172106	Hs. 110950	Rag C protein	1.652E−04	6.58	60
443547	AW271273	Hs. 23767	hypothetical protein FLJ12666	2.117E−06	6.57	95
446493	AK001389	Hs. 15144	hypothetical protein DKFZp564O043	2.734E−04	6.55	80.25
416475	T70298		gb: yd26g02.s1 Soares fetal liver spleen	1.091E−04	6.55	73
447541	AK000288	Hs. 18800	hypothetical protein FLJ20281	2.282E−03	6.55	63.75
441976	AA428403	Hs. 106131	ESTs	1.082E−04	6.55	62.75
434375	BE277910	Hs. 3833	3′-phosphoadenosine 5′-phosphosulfate sy	4.776E−06	6.52	80
408096	BE250162	Hs. 83765	dihydrofolate reductase	3.206E−03	6.52	71.25
453887	BE564037	Hs. 36237	hypothetical protein	5.688E−05	6.52	62.75
419550	D50918	Hs. 90998	KIAA0128 protein; septin 2	3.397E−07	6.50	71
416133	NM_001683	Hs. 89512	ATPase, Ca transporting, plasma membrane	3.206E−03	6.45	60.5
442993	BE018682	Hs. 166196	ATPase, Class I, type 8B, member 1	6.863E−06	6.40	77.5
413645	AA130992		gb: zo15e02.s1 Stratagene colon (937204)	4.820E−03	6.36	60.25
445525	BE149866	Hs. 14831	Homo sapiens, Similar to zinc finger pro	1.120E−06	6.35	74.5
431183	NM_006855	Hs. 250696	KDEL (Lys-Asp-Glu-Leu) endoplasmic relic	8.296E−03	6.35	61.5
434474	AL042936	Hs. 211571	holocytocbrome c synthase (cytochrome c	6.345E−03	6.32	56
435029	AF167706	Hs. 19280	cysteine-rich motor neuron 1	5.425E−03	6.32	53.5
409512	AW979187	Hs. 293591	melanoma differentiation associated prot	7.934E−08	6.27	221.5
426925	NM_001196	Hs. 315689	Homo sapiens cDNA: FLJ22373 fis. clone H	8363E−05	6.25	68.25
418476	AA648431	Hs. 37883	hypothetical protein PNAS-131	9.290E−05	6.25	65
421097	AI280112	Hs. 125232	Homo sapiens cDNA FLJ13266 fis, clone OV	1.543E−02	6.25	53.5
414405	AI362533	Hs. 306117	KIAA0306 protein	5.377E−06	6.23	68
451788	BE242857	Hs. 27021	hypothetical protein FLJ11159	3.020E−04	6.22	62
408753	AI337192	Hs. 47438	SH3 domain binding glutamic acid-rich pr	1.764E−03	6.22	54
442045	C05768	Hs. 8078	Homo sapiens clone FBD3 Cri-du-chat crit	2.024E−04	6.19	67.5
414183	AW957446	Hs. 301711	ESTs	2.024E−04	6.17	74.5
425073	W39609	Hs. 22003	solute carrier family 6 (neurotransmitte	1.838E−03	6.17	54.5
426110	NM_002913	Hs. 166563	replication factor C (activator 1)1(14	8.722E−06	6.13	65
435511	AA683336	Hs. 189046	ESTs	3.204E−03	6.11	56.25
407218	AA095473	Hs. 28505	ubiquitin-conjugating enzyme E2H (homolo	6.093E−03	6.10	66.25
422173	BE385828	Hs. 250619	phorbolin-like protein MDS019	2.582E−07	6.05	104.5
443852	AI679966	Hs. 150603	ESTs	1.692E−03	6.02	71.25
445813	Z42023	Hs. 106576	alaninE-glyoxylate aminotransferase 2-li	4.050E−04	6.02	66
413922	AI535895	Hs. 221024	ESTs	3.628E−03	6.00	78.75
440624	AF017987	Hs. 7306	secreted frizzled-related protein 1	2.595E−03	6.00	60
426458	D83032	Hs. 169984	nuclear protein	2.601E−03	6.00	57.25
418791	AA935633	Hs. 194628	ESTs	4.684E−04	5.99	89.75
437629	AW574774	Hs. 121692	ESTs	1.485E−04	5.98	51
447164	AF026941	Hs. 17518	Homo sapiens cig5 mRNA, partial sequence	2.959E−07	5.97	145.25
424699	AW206227	Hs. 287727	hypothetical protein FLJ23132	6.525E−04	5.97	54.25
443035	Z45822	Hs. 8906	Homo sapiens clone 24889 mRNA sequence	1.271E−04	5.97	50.75
452827	AI571835	Hs. 55468	ESTs	9.250E−06	5.96	103
431604	AF175265	Hs. 264190	vacuolar protein sorting 35 (yeast homol	2.024E−04	5.95	62.75
445943	AW898533	Hs. 181574	ESTs	3.331E−04	5.95	60.75
451122	AA015767	Hs. 84522	ESTs	4.624E−03	5.95	53
425167	AA351629	Hs. 225567	ESTs	2.237E−04	5.93	53
411252	AB018549	Hs. 69328	MD-2 protein	8.196E−06	5.92	103.75
423598	BE247600	Hs. 155538	ESTs	6.835E−04	5.92	51
431736	AI912234	Hs. 3297	ribosomal protein S27a	3.326E−04	5.91	83.5
410361	BE391804	Hs. 62661	guanylate binding protein 1, interferon-	5.384E−04	5.88	86
417228	AL134324	Hs. 7312	ESTs	2.953E−05	5.88	63
415938	BE383507	Hs. 78921	A kinase (PRKA) anchor protein 1	2.218E−05	5.83	77.25
427484	N32859	Hs. 37288	nuclear receptor subfamily 1. group D, m	5.068E−06	5.82	114
443291	AA325633	Hs. 136102	KIAA0853 protein	3.022E−04	5.82	78.5
424308	AW975531	Hs. 154443	minichramosome maintenance deficient (S.	4.611E−05	5.82	60
430261	AA305127	Hs. 237225	hypothetical protein HT023	7.140E−04	5.82	58.5
447735	AA775268	Hs. 6127	Homo sapiens cDNA: FLJ23020 fis, clone L	5.114E−05	5.82	48.75
419644	AU076951	Hs. 91797	retinoblastoma-binding protein 1	9.265E−06	5.80	70.75
456619	AV647917	Hs. 107153	inhibitor of growth family, member 1-lik	2.219E−05	5.80	67.25
414812	X72755	Hs. 77367	monokine induced by gamma interferon	3.893E 07	5.78	181.75
418876	AA740616		gb: ny97f11.s1 NCI_CGAP_GCB1 Homo sapiens	1.042E−05	5.75	77.5
408360	AI806090	Hs. 44344	hypothetical protein FLJ20534	1.103E−05	5.75	59.25
418224	AL036057	Hs. 83795	interferon regulatory factor 2	1.482E−04	5.75	58.25
456236	AF045229	Hs. 82280	regulator of G-protein signalling 10	3.860E−04	5.72	54.25
449609	BE246434	Hs. 289026	guanine nucleotide binding protein (G pr	3.658E−04	5.72	49
448554	NM_016169	Hs. 21431	suppressor of fused	7.897E−05	5.72	49
445529	H14421	Hs. 180513	ATP-binding cassette, sub-family A (ABC1	7.515E−05	5.70	61.75
434210	AA665612	Hs. 90093	ESTs	1.287E−07	5.67	99.5
410577	X91911	Hs. 64639	glioma pathogenesis-related protein	1.113E−06	5.67	95
400517	AF242388		lengsin	9.250E−06	5.67	73.5
438011	BE466173	Hs. 145696	splicing factor (CC1.3)	8.617E−04	5.67	64.25
456439	AA251242	Hs. 103238	ESTs	2.830E−03	5.67	48
421594	R45689	Hs. 21889	Homo sapiens cDNA FLJ12978 fis, clone NT	3.342E−03	5.65	48.75
408214	AL120445	Hs. 77823	hypothetical protein FLJ21343	4.253E−04	5.60	58
441028	AI333660	Hs. 17558	Homo sapiens cDNA FLJ14446 fis, clone HE	8.358E−05	5.59	58.5
421650	AA781795	Hs. 122587	ESTs	3.287E−06	5.57	95.75
433037	NM_014158	Hs. 279938	HSPC067 protein	9.795E−05	5.57	69.75
409277	T05558	Hs. 156880	ESTs	1.084E−03	5.57	62.5
428172	U09367	Hs. 182828	zinc finger protein 136 (clone pHZ-20)	1.490E−04	5.57	48.5
424915	R42755	Hs. 23096	ESTs	1.565E−04	5.54	46.5
431863	AA188185	Hs. 289043	spindlin	9.265E−06	5.53	148.5
457130	NM_005651	Hs. 183671	tryptophan 2,3-dioxygenase	3.622E−03	5.52	79
431122	AI267593	Hs. 250535	Homo sapiens mRNA; cDNA DKFZp434N2412 (f	3.670E−04	5.52	47.25
413509	BE145419		gb: IL5-HT0198-291099-009-E01 HT0198 Homo	7.118E−03	5.52	46.75
412802	U41518	Hs. 74602	aquaporin 1 (channel-forming integral pr	1.275E−04	5.50	95.5
416309	R84694	Hs. 79194	cAMP responsive element binding protein	4.750E−06	5.50	60.5
437730	AW071087	Hs. 239176	insulin-like growth factor 1 receptor	7.833E−04	5.50	48.5
410867	X63556	Hs. 750	fibrillin 1 (Marfan syndrome)	1.438E−02	5.50	48.25
431586	AW971100	Hs. 293189	ESTs	3.341E−03	5.47	55.75
420520	AK001978	Hs. 98510	similar to rab11-binding protein	2.701E−03	5.47	55.25
421633	AF121860	Hs. 106260	sorting nexin 10	1.201E−02	5.47	52.5
437175	AW968078	Hs. 87773	protein kinase, cAMP-dependent, catalyti	1.735E−04	5.46	62.5
428467	AK002121	Hs. 184465	hypothetical protein FLJ11259	5.146E−04	5.45	46.75
443441	AW291196	Hs. 92195	ESTs	3.555E−02	5.45	50.5
424243	AI949359	Hs. 339739	ESTs, Highly similar to cis Golgi-locali	5.416E−05	5.45	49.75
415660	AI909007	Hs. 78563	ubiquitin-conjugating enzyme E2G 1 (homo	1.596E−02	5.45	48
439008	AF075072	Hs. 167535	ESTs, Weakly similar to ALU1_HUMAN ALU S	1.297E−03	5.45	47
420789	AI670057	Hs. 199882	ESTs	4.814E−03	5.45	46.75
432388	X15218	Hs. 2969	v-ski avian sarcoma viral oncogene homol	2.734E−04	5.43	46.5
439375	AA689526	Hs. 344249	steroid dehydrogenase homolog	2.219E−05	542	64.75
413010	AA393273	Hs. 75133	transcription factor 6-like 1 (mitochond	1.846E−03	5.42	46.5
448901	AK001021	Hs. 22505	hypothetical protein FLJ10159	1.989E−06	5.40	76.75
429747	M87507	Hs. 2490	caspase 1, apoptosis-related cysteine pr	9.219E−06	5.40	69.5
453742	AB037744	Hs. 34892	KIAA1323 protein	7.173E−04	5.40	55.5
405141	Y14443		zinc finger protein 200	1.159E−02	5.40	44.5
450206	AI796450	Hs. 201600	ESTs	2.735E−04	5.38	47
422553	AI697720	Hs. 171455	ESTs, Weakly similar to T31613 hypotheti	6.857E−06	5.35	84
408048	NM_007203	Hs. 42322	A kinase (PRKA) anchor protein 2	1.240E−03	5.35	58.75
420338	AA825595	Hs. 88269	Homo sapiens, clone MGC: 17339, mRNA, com	2.123E−06	5.32	49.5
414279	AW021691		GCN5 (general control of ammo-acid synt	1.544E−02	5.30	56
449429	AA054224	Hs. 59847	ESTs	3.076E−03	5.30	52
417688	R09170	Hs. 284350	ESTs	1.487E−04	5.30	43.25
434421	AI915927	Hs. 34771	ESTs	4.454E−04	5.30	65.5
439301	AA833784	Hs. 252888	ESTs	1.085E−03	5.27	74.5
433505	AW504027	Hs. 15301	Homo sapiens cDNA FLJ12596 fis, clone NT	6.228E−04	5.27	51.25
430556	AW967807	Hs. 13797	ESTs	1.295E−03	5.26	72.5
414737	AI160386	Hs. 125087	ESTs	2.395E−06	5.25	108.25
439971	W32474	Hs. 301746	RAP2A, member of RAS oncogene family	1.753E−06	5.25	86.75
450697	AW152166	Hs. 182113	ESTs	8.621E−04	5.25	68
419490	NM_006144	Hs. 90708	granzyme A (granzyme 1, cytotoxic T-lymp	3.208E−03	5.25	55.5
433001	AF217513	Hs. 279905	clone HQ0310PRO0310p1	1.345E−04	5.23	87.75
432441	AW292425	Hs. 163484	ESTs	2.471E−04	5.22	76
449618	AI076459	Hs. 15978	KIAA1272 protein	9.832E−02	5.22	46.75
433437	U20536	Hs. 3280	caspase 6, apoptosis-related cysteine pr	1.649E−06	5.20	92.5
450916	AA011597	Hs. 177398	ESTs	7.511E−04	5.20	94.5
427699	AW965076	Hs. 180378	hypothetical protein 669	1.928E−03	5.20	53.25
421535	AB002359	Hs. 105478	phosphoribosylformylglycinamidinesyntha	6.512E−04	5.20	44.25
410511	AA743475	Hs. 285655	ESTs	2.947E−03	5.20	43
448760	AA313825	Hs. 21941	AD036 protein	2.628E−05	5.19	66
452327	AK000196	Hs. 29052	hypothetical protein FLJ20189	5.424E−05	5.17	58.25
449365	AW968261	Hs. 118913	ESTs, Moderately similar to T46371 hypot	4.097E−03	5.17	53.75
413007	BE046662		gb: hn42f02.x1 NCI_CGAP_RDF2 Homo sapiens	4.681E−04	5.17	44.5
414522	AW518944	Hs. 76325	step II splicing factor SLU7	4.684E−04	5.16	139.25
451081	AI078645	Hs. 431	murine leukemia viral (bmi-1) oncogene h	2.490E−03	5.15	49.25
437834	AA769294	Hs. 283854	gb: nz36g03.s1 NCI_CGAP_GCB1 Homo sapiens	3.307E−04	5.13	55.5
458965	AA010319	Hs. 60389	ESTs	3.856E−04	5.13	41.75
442878	AI868648	Hs. 22315	ESTs	3.672E−04	5.10	58.75
410337	M83822	Hs. 62354	cell division cycle 4-like	1.652E−04	5.10	55.75
422267	AB033044	Hs. 114012	KIAA1218 protein	1.405E−04	5.10	47.25
438865	H64256	Hs. 167619	ESTs, Moderately similar to ALUC_HUMAN!	3.034E−02	5.10	42.5
438914	N93892	Hs. 10727	ESTs	5.630E−03	5.10	43
407204	R41933	Hs. 140237	ESTs, Weakly similar to ALU1_HUMAN ALU S	1.663E−05	5.07	61.5
431049	AA846576	Hs. 103267	hypothetical protein FLJ22548 similar to	7.687E−06	5.07	55.5
417355	D13168	Hs. 82002	endothelin receptor type B	5.142E−02	5.07	45.25
419522	AI682428	Hs. 157728	ESTs	8.292E−05	5.05	48.25
433697	AA600357	Hs. 239489	TIA1 cytotoxic granule-associated RNA-bi	5.421E−03	5.02	48.25
428420	AL096858	Hs. 184245	KIAA0929 protein Msx2 interacting nuclea	7.583E−07	5.01	128.25
434658	AI624436	Hs. 310286	ESTs	6.092E−06	5.00	113.25
430268	AK000737	Hs. 237480	hypothetical protein FLJ20730	1.480E−03	5.00	50.75
426052	N49068	Hs. 93966	ESTs	7.107E−05	5.00	47.25
450086	AW016343	Hs. 233301	ESTs	2.491E−03	5.00	47
430512	AF182294	Hs. 241578	U6 snRNA-associated Sm-like protein LSm8	1.038E−02	5.00	44.5
456034	AW450979		gb: UI-H-BI3-ata-a-12-0-Ul.s1 NCI_CGAP_Su	9.642E−03	5.00	40.75
432606	NM_002104	Hs. 3066	granzyme K (serine protease, granzyme 3;	2.094E−05	4.99	146.5
431620	AA126109	Hs. 264981	2′-5′-oligoadenylate synthetase 2 (69-71	7.389E−08	4.98	241.75
440043	BE277457	Hs. 30661	hypothetical protein MGC4606	1.297E−03	4.97	43.25
427008	Z45258	Hs. 286013	short coiled-coil protein	2.785E−05	4.97	68.5
443884	N20617	Hs. 194397	leptin receptor	4.448E−03	4.95	74.25
444670	H58373	Hs. 332938	hypothetical protein MGC5370	3.017E−04	4.95	65
424852	AI222779	Hs. 144848	ESTs	6.341E−03	4.95	48
450747	AI064821	Hs. 318535	ESTs, Highly similar to 1818357A EWS gen	3.670E−02	4.95	45
411360	AK001601	Hs. 69594	high-mobility group 20A	5.639E−03	4.95	45
407366	AF026942	Hs. 271530	gb: Homo sapiens cig33 mRNA, partial sequ	8.647E−07	4.92	115.5
422150	AI867118	Hs. 279607	calpastatin	1.437E−02	4.92	42
419135	R61448	Hs. 106728	ESTs, Weakly similar to KIAA1353 protein	5.724E−06	4.92	115.75
414646	AA353776	Hs. 901	CD48 antigen (B-cell membrane protein)	2.413E−06	4.90	87.5
450447	AF212223	Hs. 25010	hypothetical protein P15-2	4.456E−04	4.90	54
434158	T86534	Hs. 14372	ESTs	2.190E−03	4.90	46.75
420151	AA255931	Hs. 186704	ESTs	2.209E−05	4.90	46.75
408831	AF090114	Hs. 48433	endocrine regulator	1.732E−04	4.90	41.25
449500	AW956345	Hs. 12926	ESTs	2.839E−02	4.90	40.75
418662	AI801098	Hs. 151500	ESTs	1.716E−02	4.88	49.25
416050	U51903	Hs. 78993	IQ motif containing GTPase activating pr	2.108E−02	4.88	43
451338	AW612322	Hs. 19131	transcription factor Dp-2 (E2F dimerizat	2.730E−04	4.86	40.5
449523	NM_000579	Hs. 54443	chemokine (C-C motif) receptor 5	1.871E−05	4.85	59.5
423857	N48902	Hs. 133481	Homo sapiens mRNA; cDNA DKFZp564O0862 (f	1.764E−03	4.82	58.75
427384	T82854		gb: yd42a09.r1 Soares fetal liver spleen	2.180E−02	4.82	43.75
451273	NM_014811	Hs. 26163	KIAA0649 gene product	9.414E−04	4.82	38.25
456508	AA502764	Hs. 123469	ESTs, Weakly similar to AF208855 1 BM-01	1.298E−03	4.81	55.25
457584	AA147979	Hs. 285005	mitochondrial import receptor Tom22	5.139E−05	4.80	57
443998	AI620661	Hs. 296276	ESTs	2.290E−03	4.77	77
454075	R43826	Hs. 16313	Kruppel-like zinc finger protein GLIS2	2.100E−03	4.77	58.5
407609	R43159	Hs. 238432	ESTs	9.450E−04	4.77	54.75
424683	N87519	Hs. 27196	ESTs	1.650E−04	4.77	52.5
452820	N46161	Hs. 35274	ESTs	2.103E−03	4.77	46.75
441866	BE464341	Hs. 21201	nectin 3; DKFZP566B0846 protein	3.134E−02	4.77	40.5
429966	BE081342	Hs. 283037	HSPC039 protein	5.784E−02	4.77	39
449613	N63808	Hs. 34299	ESTs	2.725E−06	4.75	102
409703	NM_006187	Hs. 56009	2′-5′-oligoadenylate synthetase 3 (100 k	5.544E−08	4.75	441
439334	AI148976	Hs. 112062	ESTs	3.154E−04	4.74	40.25
410382	AW664971	Hs. 259546	ESTs	1.207E−04	4.72	57.75
434926	BE543269	Hs. 50252	mitochondrial ribosomal protein L32	1.733E−04	4.72	57
433198	AA992841	Hs. 27263	KIAA1458 protein	1.339E−02	4.72	44
435970	H75410	Hs. 54452	zinc finger protein, subfamily 1 A, 1 (Ik	5.395E−04	4.70	46.25
416647	BE297139	Hs. 79411	replication protein A2 (32 kD)	3.670E−04	4.68	66.25
409038	T97490	Hs. 50002	small inducible cytokine subfamily A (Cy	2.243E−04	4.68	193
429952	AF080158	Hs. 226573	inhibitor of kappa light polypeptide gen	3.684E−05	4.67	67.5
413048	M93221	Hs. 75182	mannose receptor, C type 1	7.864E−04	4.67	52.25
425068	AL048716	Hs. 154387	KIAA0103 gene product	2.843E−02	4.67	40.75
450401	AW959281	Hs. 8184	ESTs	1.547E−03	4.67	39.75
402727			NM_025065: Homo sapiens hypothetical prot	1.118E−02	4.67	55
449209	BE616830	Hs. 294145	ESTs	3.170E−04	4.66	58.5
432600	AI821085		gb: ns95a12.y5 NCI_CGAP_Pr3 Homo sapiens	2.022E−04	4.65	84.25
441892	AB028981	Hs. 8021	KIAA1058 protein	1.867E−05	4.65	55.5
407284	AI539227	Hs. 214039	hypothetical protein FLJ23556	8.131E−02	4.65	51.75
450516	AA902656	Hs. 21943	NIF3 (Ngg1 interacting factor 3, S. pombe	3.658E−04	4.65	49
426728	NM_007118	Hs. 171957	triple functional domain (PTPRF interact	6.500E−02	4.64	41
449909	AA004681	Hs. 59432	ESTs	1.767E−03	4.63	37.25
409401	AI201895	Hs. 181309	proteasome (prosome, macropain) subunit,	4.052E−04	4.63	61
450669	AL138077	Hs. 16157	hypothetical protein FLJ12707	7.864E−04	4.63	36.25
408405	AK001332	Hs. 44672	hypothetical protein FLJ10470	3.393E−07	4.61	115.5
451079	AI827988	Hs. 240728	ESTs, Moderately similar to PC4259 ferri	8.821E−05	4.60	60.5
408108	AI580492	Hs. 42743	hypothetical protein	5.663E−04	4.60	47.75
453555	N23574	Hs. 123649	ESTs, Moderately similar to ALU7_HUMAN A	2.764E−05	4.60	40.25
437967	BE277414	Hs. 5947	mel transforming oncogene (derived from	8.298E−03	4.59	71.75
435260	H64245	Hs. 34458	ESTs	2.194E−03	4.59	36.75
425100	AF051850	Hs. 154567	supervillin	5.865E−03	4.58	38.5
447023	AA356764	Hs. 17109	integral membrane protein 2A	6.056E−05	4.57	92
408705	AA312135	Hs. 46967	HSPCO34 protein	1.044E−06	4.57	62.5
424626	AA344308	Hs. 128427	Homo sapiens BAC clone RP11-335J18 from	1.399E−05	4.57	61.25
413786	AW613780	Hs. 13500	ESTs	1.966E−07	4.57	60
432572	AI660840	Hs. 191202	ESTs, Weakly similar to ALUE_HUMAN !!!!	7.522E−04	4.55	80.75
446927	AW503484	Hs. 16533	myosin phosphatase, target subunit 1	1.596E−02	4.55	42.25
417052	NM_000712	Hs. 81029	biliverdin reductase A	5.081E−06	4.55	110
437456	AL047045	Hs. 60293	Homo sapiens clone 122482 unknown mRNA	2.477E−04	4.54	74.25
411590	T96183		gb: ye09f07.s1 Stratagene lung (937210) H	3.777E−03	4.53	46.75
401091	F07783		decay accelerating factor for complement	9.445E−04	4.52	56
423250	BE061916	Hs. 125849	chromosome 8 open reading frame 2	1.077E−02	4.52	49.75
429732	U20158	Hs. 2488	lymphocyte cytosolic protein 2 (SH2 doma	1.292E−02	4.52	36.25
409549	AB029015	Hs. 54886	phospholipase C, epsilon 2	3.841E−04	4.52	45.75
409461	AA382169	Hs. 54483	N-myc (and STAT) interactor	1.490E−07	4.50	197
451253	H48299	Hs. 26126	claudin 10	9.284E−05	4.50	92.75
443119	AA312264	Hs. 7980	hypothetical protein MGC12966	2.021E−04	4.50	43
423954	AW753164	Hs. 288604	KIAA1632 protein	1.241E−03	4.48	36.5
433226	AW503733	Hs. 9414	KIAA1488 protein	4.251E−04	4.47	68.25
429276	AF056085	Hs. 198612	G protein-coupled receptor 51	2.232E−04	4.47	64.75
419743	AW408762	Hs. 5957	Homo sapiens clone 24416 mRNA sequence	8.609E−03	4.47	43.75
432967	AA572949	Hs. 207566	ESTs	5.637E−04	4.47	41.75
417973	NM_004490	Hs. 83070	growth factor receptor-bound protein 14	1.339E−02	4.47	40.75
417954	AI633943	Hs. 26613	ESTs, Weakly similar to no similarities	3.787E−02	4.47	39.25
421654	AW163267	Hs. 106469	suppressor of var1 (S. cerevisiae) 3-like	2.178E−02	4.47	39.25
445776	NM_001310	Hs. 13313	cAMP responsive element binding protein-	1.339E−02	4.47	35.5
430008	AW085625	Hs. 186838	ESTs, Weakly similar to Z295_HUMAN ZINC	3.203E−03	4.47	55.5
421215	AI868634	Hs. 246358	ESTs, Weakly similar to T3225tt hypotheti	1.662E−05	4.46	71.75
430293	AI416988	Hs. 238272	inositol 1,4,5-triphosphate receptor, ty	1.149E−04	4.45	104.5
428342	AI739168		Homo sapiens cDNA FLJ13458 fis, clone PL	1.107E−05	4.45	85.5
446839	BE091926	Hs. 16244	mitotic spindle coiled-coil related prot	2.947E−03	4.45	53
434941	AW073202	Hs. 334825	Homo sapiens cDNA FLJ14752 fis, clone NT	8.634E−04	4.45	50.75
421181	NM_005574	Hs. 184585	LIM domain only 2 (rhombotin-like 1)	1.845E−03	4.45	39.25
421508	NM_004833	Hs. 105115	absent in melanoma 2	7.103E−05	4.43	51.5
441652	BE467811	Hs. 7471	BBP-like protein 1	9.630E−03	4.43	43.75
429105	D87077	Hs. 196275	KIAA0240 protein	2.412E−02	4.42	34.5
439223	AW238299	Hs. 250618	UL16 binding protein 2	1.083E−03	4.42	41
446770	AV660309	Hs. 154986	ESTs, Weakly similar to PLLP_HUMAN PLASM	7.916E−02	4.42	45.25
436535	AW295687	Hs. 254420	ESTs	1.169E−05	4.40	59.5
413243	AA769266	Hs. 193657	ESTs	2.945E−03	4.40	52.25
408461	AB037756	Hs. 45207	hypothetical protein KIAA1335	6.091E−03	4.40	36.75
432873	AW837268	Hs. 279639	Homo sapiens mRNA; cDNA DKFZp586M2022 (f	1.928E−03	4.40	34.25
416701	R94977	Hs. 35416	PRO0132 protein	1.928E−03	4.39	51.75
450746	D82673	Hs. 278589	general transcription factor II. i	7.536E−07	4.39	133.75
432435	BE218886	Hs. 282070	ESTs	9.808E−05	4.38	90.75
421685	AF189723	Hs. 106778	ATPase, Ca transporting, type 2C, member	5.412E−04	4.38	45.5
419951	AI653415	Hs. 195789	ESTs	9.022E−04	4.38	44.75
424960	BE245380	Hs. 153952	5′ nucleotidase (CD73)	2.841E−02	4.38	40.25
410099	AA081630		KIAA0036 gene product	2.038E−02	4.38	35.25
422879	AI241409	Hs. 188092	ESTs	2.021E−04	4.35	65.75
438769	AA830684	Hs. 163426	ESTs	1.419E−03	4.35	64.75
443084	AI827639	Hs. 125539	ESTs	8.228E−04	4.35	62.75
417363	AW129357	Hs. 329700	ESTs	3.627E−03	4.35	51
408162	AA993833	Hs. 118527	ESTs	8.270E−03	4.35	33.5
421379	Y15221	Hs. 103982	small inducible cytokine subfamily B (Cy	3.401E−07	4.34	115.25
414462	BE622743	Hs. 301064	arfaptin 1	1.299E−03	4.34	59.25
410245	C17908	Hs. 194125	ESTs	6.345E−03	4.32	44
434666	AF151103	Hs. 112259	T cell receptor gamma locus	1.146E−04	4.30	52.25
431328	AA502999	Hs. 291591	ESTs	1.211E−04	4.30	46
452939	R35348	Hs. 24970	ESTs, Weakly similar to B34323 GTP-bindi	5.213E−03	4.30	36.25
426030	BE243933	Hs. 108642	zinc finger protein 22 (KOX 15)	2.037E−02	4.30	38.75
417819	AI253112	Hs. 133540	ESTs	5.295E−02	4.30	36.25
429922	Z97630	Hs. 226117	H1 histone family, member 0	2332E−02	4.29	48.5
428255	AI627478	Hs. 187670	ESTs	5.672E−04	4.28	44.25
407690	R47799	Hs. 266957	hypothetical protein FLJ14281	2.107E−07	4.27	93.75
447887	AA114050	Hs. 19949	caspase 8, apoptosis-related cysteine pr	2.465E−04	4.27	50
446751	AA766998	Hs. 79126	Human DNA sequence from clone RP11-16L21	6.861E−03	4.27	45.75
432610	BE246615	Hs. 278507	histidyl-tRNA synthetase-like	8.625E−04	4.27	38.5
434198	AF119849	Hs. 283028	hypothetical protein PRO1598	1.417E−03	4.27	35.75
425387	AB037864	Hs. 156051	KIAA1443 protein	3.843E−04	4.27	35.75
407309	AA526438	Hs. 281680	peroxisomal trans 2-enoyl CoA reductase;	3.682E−05	4.27	41.75
429588	AI080271	Hs. 134533	ESTs	1.693E−03	4.27	48.25
434987	AW975114	Hs. 293273	ESTs	1.297E−03	4.25	79
432195	AJ243669	Hs. 8127	KIAA0144 gene product	7.510E−05	4.25	58
433847	AA610266		ESTs	2.477E−04	4.25	43
428720	T90468	Hs. 178154	ESTs	1.083E−03	4.25	39.5
419110	AA234171	Hs. 187626	ESTs	1.410E−04	4.25	35.75
411656	AW855576		gb: CM4-CT0278-221099-027-d01 CT0278 Homo	2.011E−03	4.25	32.5
448071	BE621584	Hs. 6983	Homo sapiens cDNA: FLJ22646 fis, clone H	6.035E−05	4.23	46
447513	AW955776	Hs. 313500	ESTs, Moderately similar to ALU7_HUMAN A	1.118E−06	4.22	84.75
440201	AL359588	Hs. 7041	hypothetical protein DKFZp7628226	1.841E−03	4.22	42.75
425272	AA354138	Hs. 47209	ESTs, Weakly similar to C35826 hypotheti	2.599E−03	4.22	38.25
453793	AK002178	Hs. 35225	hypothetical protein FLJ11316	7.404E−03	4.22	35
440193	AW902312	Hs. 7037	Homo sapiens clone 24923 mRNA sequence	3.909E−02	4.22	33.5
442061	AA774284	Hs. 285728	abl-interactor 12 (SH3-containing protei	8.228E−04	4.20	38.25
402507			Target Exon	5.392E−04	4.20	35.5
430569	AF241254	Hs. 178098	angiotensin I converting enzyme (peptidy	5.621E−02	4.20	35.5
454067	AA041455	Hs. 209312	ESTs	2.602E−04	4.18	44.5
431966	AB037903	Hs. 272257	Homo sapiens truncated AKR mRNA for trun	1.246E−02	4.18	40.5
452032	BE244005	Hs. 27610	retinoic acid- and interferon inducible	1.737E−04	4.17	70.25
402964			NM_022095*: Homo sapiens hypothetical C2H	1.134E−03	4.17	45.75
436860	H12751	Hs. 5327	PRO1914protein	7.165E−04	4.17	70.5
435513	AW404075	Hs. 42785	DC11 protein	1.156E−02	4.15	43.75
447094	X65232	Hs. 17364	zinc finger protein 79 (pT7)	4.674E−04	4.15	31.75
453394	AW960474	Hs. 40289	ESTs	1.483E−05	4.13	78.25
408392	U28831	Hs. 44566	KIAA1641 protein	8.228E−04	4.13	61.25
417601	NM_014735	Hs. 82292	KIAA0215 gene product	2.475E−04	4.13	45
406423			C19000229*: gi|6753826|ref|NP_034311.1|f	7.487E−02	4.13	31.25
435126	AI393666	Hs. 42315	p10-binding protein	1.967E−02	4.12	33.5
416987	D86957	Hs. 80712	KIAA0202 protein	1.298E−03	4.10	62.75
433556	W56321	Hs. 111460	calcium/calmodulin-dependent protein kin	1.084E−04	4.10	52.75
414449	AA557660	Hs. 76152	decorin	1.970E−02	4.10	46.5
420000	AB036063	Hs. 94262	p53-inducible ribonucleotide reductase s	5.963E−02	4.10	38.5
418720	AI381687	Hs. 39526	ESTs	1.038E−02	4.10	38
427205	Z45791	Hs. 173946	hypothetical protein FLJ10486	2.178E−02	4.10	33
410541	AA065003	Hs. 64179	syntenin-2 protein	1.038E−03	4.09	82
411400	AA311919	Hs. 69851	nucleolar protein family A, member 1 (H/	9.789E−05	4.08	54.75
422541	NM_005131	Hs. 1540	nuclear matrix protein p84	2.284E−03	4.08	37.75
419943	AA252111	Hs. 15200	ESTs	2.874E−04	4.08	60.75
419195	AW291165	Hs. 25447	ESTs	1.135E−03	4.07	51.5
424939	AK000059	Hs. 153881	Homo sapiens NY-REN-62 antigen mRNA, par	5.299E−02	4.06	39.75
419590	AF005043	Hs. 91390	poly (ADP-ribose) glycohydrolase	9.272E−05	4.05	42
430468	NM_004673	Hs. 241519	angiopoietin-like 1	3.204E−03	4.05	68.5
406038	Y14443		zinc finger protein 200	1.546E−03	4.05	67.75
430522	N75750	Hs. 242271	KIAA0471 gene product	1.768E−03	4.05	41.25
424848	AI263231	Hs. 327090	EST	4.440E−03	4.05	61.75
452695	AW780199	Hs. 30327	mitogen-activated protein kinase-activat	1.480E−03	4.04	34.25
451593	AF151879	Hs. 26706	CGI-121 protein	8.336E−05	4.02	65.5
408548	AA055449	Hs. 63187	ESTs, Weakly similar to ALUC_HUMAN !!!!	1.620E−03	4.02	38.75
402439			C1002445*: gi|4506787|ref|NP_003861.1|IQ	3.342E−02	4.02	32.75
442202	BE272862	Hs. 106534	hypothetical protein FLJ22625	1.565E−04	4.00	64.5
433233	AB040927	Hs. 301804	KIAA1494 protein	2.389E−03	4.00	43.5
407992	AW418811		gb: ha21a06.x1 NCI_CGAP_Kid12 Homo sapien	7.959E−03	4.00	38.25
450222	U75308	Hs. 24644	TATA box binding protein (TBP)-associate	5.152E−04	3.99	66.5
432676	AI187366		gb: qf29c01.x1 Soares_testis_NHT Homo sap	7.934E−05	3.98	49.25
427209	H06509	Hs. 92423	KIAA1566 protein	3.731E−06	3.98	126
416999	AW195747	Hs. 21122	hypothetical protein FLJ11830 similar to	1.088E−04	3.97	56.5
442485	BE092285	Hs. 29724	hypothetical protein FLJ13187	4.100E−03	3.97	52.5
425395	NM_014102	Hs. 156243	PRO1848 protein	1.922E−04	3.97	44.75
424238	AA337401	Hs. 137635	ESTs	7.396E−03	3.97	36.75
400417	X72475	Hs. 156110	Target	1.903E−02	3.97	34.75
415323	BE269352	Hs. 949	neutrophil cytosolic factor 2 (65 kD, chr	7.689E−03	3.96	49.5
433017	Y15067	Hs. 279914	zinc finger protein 232	3.665E−05	3.95	31
444985	AI677737	Hs. 28329	hypothetical protein FLJ14005	7.496E−04	3.95	90.75
426108	AA622037	Hs. 166468	programmed cell death 5	3.032E−02	3.95	43.5
441889	AI090455	Hs. 268371	hypothetical protein FLJ20274	1.001E−02	3.95	38.5
443970	AI280341	Hs. 166571	ESTs	6.136E−02	3.95	37.75
449001	AI619957		ESTs	7.682E−03	3.93	33
427213	AW007211		hypothetical protein FLJ 12876	2.601E−03	3.92	73.75
449964	AW001741	Hs. 24243	hypothetical protein FLJ10706	3.843E−04	3.92	44.5
421443	BE550141	Hs. 156148	hypothetical protein FLJ13231	3.019E−04	3.92	42.25
411412	AJ001388	Hs. 69997	zinc finger protein 238	1.899E−02	3.92	32
449832	AA694264	Hs. 60049	ESTs	1.599E 02	3.92	38
419737	H24185	Hs. 92918	hypothetical protein	6.528E−04	3.90	45.5
436165	AI373544	Hs. 331328	intermediate filament protein syncoilin	7.106E−03	3.90	42.75
437862	AW978107	Hs. 5884	Homo sapiens mRNA; cDNA DKFZp586C0224 (f	1.187E−03	3.90	40.5
425210	AA054679	Hs. 155150	ribonuclease P(14 kD)	4.090E−03	3.90	31.25
442287	AW952703	Hs. 8182	synaptic nuclei expressed gene 1b	1.187E−03	3.88	55.5
439559	AW364675	Hs. 173921	ESTs, Weakly similar to 2109260A B cell	1.642E−04	3.88	58.25
450427	AK001436	Hs. 24994	CGI-53 protein	5.957E−02	3.88	32.25
421919	AJ224901	Hs. 109526	zinc finger protein 198	1.925E−04	3.87	85.25
443601	AI078554	Hs. 15682	ESTs	3.122E−05	3.86	79.5
449509	AA001615	Hs. 84561	ESTs	7.111E−03	3.85	36.25
456107	AA160000	Hs. 137396	ESTs, Weakly similar to JC5238 galactosy	1.035E−02	3.85	30.25
422550	BE297626	Hs. 296049	microfibrillar-associated protein 4	2.574E−02	3.85	51.25
408683	R58665	Hs. 46847	TRAF and TNF receptor-associated protein	4.448E−07	3.85	106
426860	U04953	Hs. 172801	isoleucine-tRNA synthetase	4.619E−03	3.84	45.5
438459	T49300	Hs. 35304	Homo sapiens cDNA FLJ13655 fis. clone PL	2.088E−05	3.83	80.75
431266	AW149321	Hs. 105411	ESTs	1.090E−04	3.83	99.75
418304	AA215702		gb: zr97g10.r1 NCI_CGAP_GCB1 Homo sapiens	7.169E−04	3.82	48
435354	AA678267	Hs. 117115	ESTs	1.968E−02	3.82	36.75
403575			Target Exon	6.831E−04	3.82	30.5
442961	BE614474	Hs. 289074	F-box only protein 22	1.321E−05	3.82	76.25
412651	AA115333	Hs. 107968	ESTs	5.809E−07	3.81	128.75
448965	AF092134	Hs. 22679	CGI-24 protein	1.871E−05	3.81	60.5
450056	BE047394	Hs. 8208	ESTs, Weakly similar to S71512 hypotheti	7.505E−05	3.81	71
428330	L22524	Hs. 2256	matrix metalloproleinase 7 (matrilysin,	5.871E−03	3.81	77.25
428234	U93553	Hs. 183123	nuclear receptor subfamily 5, group A, m	5.142E−02	3.81	33
441646	AB023169	Hs. 7935	KIAA0952 protein	1.968E−02	3.80	38.25
402847			C1000826*: gi|12314084|emb|CAC05321.1|(A	1.156E−02	3.80	31.75
446207	AW968535	Hs. 14328	hypothetical protein FLJ20071	1.489E−02	3.80	34.25
414658	X58528	Hs. 76781	ATP-binding cassette, sub-family D (ALD)	2.011E−03	3.80	61.5
421965	AA301100	Hs. 346482	gb: EST14128 Testis tumor Homo sapiens cD	1.663E−05	3.79	87.25
414219	W20010	Hs. 75823	ALL1-fused gene from chromosome 1q	2.180E−02	3.78	35.5
436385	BE551618	Hs. 144097	ESTs	7.990E−03	3.77	56
432689	AB018320		Arg/Abl-interacting protein ArgBP2	6.099E−03	3.77	42.25
423450	AJ290445	Hs. 128759	KIAA0524 protein	2.602E−04	3.77	32.75
429031	BE002237	Hs. 239666	Homo sapiens cDNA FLJ13495 fis, clone PL	3.071E−03	3.77	31
434526	AW085147	Hs. 152779	ESTs	4.278E−02	3.77	30.75
416039	AA376989	Hs. 78989	alcohol dehydrogenase 5 (class III), chi	3.175E−04	3.77	72.75
414915	NM_002462	Hs. 76391	myxovirus (influenza) resistance 1, homo	7.398E−08	3.77	628.75
424003	BE274717	Hs. 137506	Homo sapiens, clone IMAGE: 3605104, mRNA,	5.008E−03	3.75	46
432409	AA806538	Hs. 130732	KIAA1575 protein	1.775E−02	3.75	36.75
415736	AA827082	Hs. 291872	ESTs	5.845E−03	3.75	36
423932	T95633	Hs. 189703	ESTs	7.687E−03	3.74	52.75
434733	AI334367	Hs. 159337	ESTs	1.341E−04	3.72	55.5
420926	AA830402	Hs. 221216	ESTs	2.037E−02	3.72	48
453070	AK001465	Hs. 31575	SEC63, endoplasmic reticulum translocon	1.339E−02	3.72	47.75
426310	NM_000909	Hs. 169266	neuropeptide Y receptor Y1	7.692E−03	3.72	44.25
453753	BE252983	Hs. 35086	ubiquitin specific protease 1	8.588E−03	3.72	41
430016	NM_004736	Hs. 227656	xenotropic and polytropic retrovirus rec	1.598E−02	3.72	37.5
401016			ENSP00000227126: NAALADASE II PROTEIN.	6.847E−03	3.72	35.5
447892	AI435848	Hs. 172978	ESTs	1.246E−02	3.72	34.25
425397	J04088	Hs. 156346	topoisomerase (DNA) II alpha (170 kD)	1.599E−02	3.72	31
407756	AA116021	Hs. 38260	ubiquitin specific protease 18	1.600E−07	3.72	269.75
431392	AI371223	Hs. 288671	Homo sapiens cDNA FLJ11997 fis, clone HE	1.300E−03	3.72	60.5
451658	AW195351	Hs. 250520	ESTs, Moderately similar to I38022 hypot	6.060E−05	3.72	62.5
451406	AI694320	Hs. 6295	ESTs, Weakly similar to T17248 hypotheti	9.882E−04	3.71	56.25
408216	AA741038	Hs. 6670	ESTs	1.084E−03	3.70	58.75
417848	AA206581	Hs. 86041	ESTs, Weakly similar to JC5314 CDC28/cdc	7.162E−04	3.70	59.75
434924	AA443164	Hs. 23259	hypothetical protein FLJ13433	1.321E−05	3.70	54
442085	AA975688	Hs. 159955	ESTs	3.339E−03	3.70	44.75
444363	AI142827	Hs. 143656	ESTs	2.723E−04	3.70	44
433891	AA613792		gb: no97h03.s1 NCI_CGAP_Pr2 Homo sapiens	4.811E−03	3.70	41
425423	NM_005897	Hs. 157180	intracisternal A particle-promoted polyp	1.915E−04	3.70	36.75
409493	AA386192	Hs. 193482	Homo sapiens cDNA FLJ11903 fis, clone HE	1.776E−02	3.70	34
451730	AF095687	Hs. 26937	brain and nasopharyngeal carcinoma susce	3.129E−02	3.70	34
419511	AA429750	Hs. 75113	general transcription factor IIIA	5.637E−03	3.70	30
452664	AA398859	Hs. 18397	hypothetical protein FLJ23221	8.629E−07	3.69	124.5
430478	NM_014349	Hs. 241535	apolipoprotein L, 3	5.537E−08	3.69	387
421406	AF179897	Hs. 104105	Meis (mouse) homolog 2	5.643E−03	3.68	51.5
429686	AI871613	Hs. 28538	Homo sapiens cDNA: FLJ21086 fis, clone C	2.193E−03	3.67	48.75
429680	AL035754	Hs. 2474	toll-like receptor 1	6.219E−04	3.67	38.25
423494	AW504365	Hs. 24143	Wiskott-Aldrich syndrome protein interac	3.203E−03	3.67	35.75
444545	AW995346	Hs. 146910	ESTs	1.899E−02	3.67	30.75
433907	AW296107	Hs. 152686	ESTs	5.660E−04	3.67	63.5
437650	AA814338	Hs. 292297	ESTs	7.118E−03	3.67	38.75
452279	AA286844	Hs. 61260	hypothetical protein FLJ13164	7.283E−02	3.65	36.5
444969	AI203334	Hs. 160628	ESTs	9.976E−03	3.65	37.75
431560	BE244135	Hs. 260238	hypothetical protein FLJ 10842	2.942E−03	3.65	37.5
425757	AA363171		gb: EST72986 Ovary II Homo sapiens cDNA 5	1.341E−04	3.65	33
433464	N92481		gb: zb12g02.s1Soares_fetal_lung_NbHL19W	8.945E−03	3.65	30.25
446111	W56338	Hs. 13880	CGI-143 protein	2.290E−03	3.65	35.75
446506	AI123118	Hs. 15159	chemokine-like factor, alternatively spl	3.386E−07	3.63	131
436503	AJ277750	Hs. 183924	ubiquitin associated and SH3 domain cont	4.097E−03	3.63	33.5
451938	AI354355	Hs. 16697	down-regulator of transcription 1, TBP-b	1.921E−04	3.63	69.75
421114	AW975051	Hs. 293156	ESTs, Weakly similar to I78885 serine/th	4.444E−03	3.63	68.25
449720	AA311152	Hs. 288708	hypothetical protein FLJ21562	4.468E−06	3.63	63.75
443373	AI792868	Hs. 135365	ESTs	4.099E−03	3.63	49
417148	AA359896	Hs. 293885	hypothetical protein FLJ14902	1.837E−02	3.63	49
457231	AI472022	Hs. 301959	proline synthetase co-transcribed (bacte	3.450E−02	3.63	32.75
408380	AF123050	Hs. 44532	diubiquitin	4.434E−07	3.62	217.25
425692	D90041	Hs. 155956	N-acetyltransferase 1 (arylamine N-acety	1.760E−05	3.60	66.5
443968	AA287702	Hs. 10031	KIAA0955 protein	8.945E−03	3.60	58.25
428250	AW809208	Hs. 183297	DKFZP566F2124 protein	5.932E−04	3.60	54
407946	AA226495	Hs. 154292	ESTs	1.903E−04	3.60	53
412828	AL133396	Hs. 74621	prion protein (p27-30) (Creutzfeld-Jakob	4.990E−02	3.60	50.25
418699	BE539639	Hs. 173030	ESTs, Weakly similar to ALU8_HUMAN ALU S	4.813E−03	3.60	43.5
431416	AA532718	Hs. 178604	ESTs	8.139E−02	3.60	37
425345	AU077297	Hs. 155894	protein tyrosine phosphatase, non-recept	3.773E−03	3.60	36.75
422303	AW410382	Hs. 27556	hypothetical protein FLJ22405	5.301E−02	3.60	36.75
456760	AW961251	Hs. 127828	guanine nucleotide binding protein (G pr	1.084E−03	3.60	33
434936	AI285970	Hs. 183817	ESTs	6.881E−02	3.59	56.25
448192	R43915	Hs. 4958	ESTs	4.440E−03	3.58	31
408618	AK000637	Hs. 46624	HSPC043 protein	7.694E−03	3.58	43.25
427051	BE178110	Hs. 173374	Homo sapiens cDNA FLJ10500 fis, clone NT	1.201E−02	3.58	40
430024	AI808780	Hs. 227730	integrin, alpha 6	7.913E−05	3.57	68.75
424881	AL119690	Hs. 153618	HCGVIII-1 protein	2.010E−03	3.57	40.25
408438	AB011180	Hs. 100960	KIAA0608 protein	1.076E−02	3.57	38
427471	AA403131	Hs. 266782	KIAA1826 protein	2.494E−03	3.57	34
432769	AA620814	Hs. 144959	ESTs	4.558E−02	3.57	31.25
426181	AA371422	Hs. 334371	hypothetical protein MGC13096	7.162E−04	3.57	34.75
439195	H89360		gb: yw28d08.s1 Morton Fetal Cochlea Homo	4.621E−03	3.57	41.75
444020	R92962	Hs. 35052	ESTs	1.970E−02	3.57	48.75
419908	AW971327	Hs. 293315	ESTs	9.289E−03	3.56	32
427581	NM_014788	Hs. 179703	KIAA0129 gene product	1.489E−07	3.55	117.5
419440	AB020689	Hs. 90419	KIAA0882 protein	2.478E−04	3.55	57.75
409342	AU077058	Hs. 54089	BRCA1 associated RING domain 1	6.528E−04	3.55	47.25
410054	AL120050	Hs. 58220	Homo sapiens cDNA: FLJ23005 fis, clone L	1.076E−02	3.55	38
437133	AB018319	Hs. 5460	KIAA0776 protein	1.774E−02	3.55	35.25
423886	AA332098		gb: EST36256 Embryo, 8 week I Homo sapien	1.116E−02	3.55	33
432540	AI821517	Hs. 105866	ESTs	3.620E−03	3.54	43.25
402737			Target Exon	4.105E−05	3.54	38.75
421977	W94197	Hs. 110165	ribosomal protein L26 homolog	6.855E−02	3.54	40
418222	AI675881	Hs. 86538	ESTs	2.592E−03	3.53	40.5
418793	AW382987	Hs. 88474	prostaglandin-endoperoxide synthase 1 (p	8.283E−03	3.53	34.75
417301	AI478158	Hs. 164478	hypothetical protein FLJ21939 similar to	1.083E−03	3.52	51
412863	AA121673	Hs. 59757	zinc finger protein 281	2.250E−02	3.52	45.25
439763	AA845366	Hs. 184075	ESTs, Weakly similar to ALU1_HUMAN ALU S	1.033E−03	3.52	42.25
403809			NM_024743*: Homo sapiens hypothetical pro	1.490E−02	3.52	41.75
421684	BE281591	Hs. 106768	hypothetical protein FLJ10511	1.117E−02	3.52	41.75
436271	AW449686	Hs. 129828	ESTs	1.563E−04	3.52	37.25
445240	AI217385	Hs. 147574	ESTs	1.599E−02	3.52	34.5
432834	F06459	Hs. 289113	cytochrome b5 reductase 1 (B5R.1)	9.286E−03	3.52	31.75
426780	BE242284	Hs. 172199	adenylate cyclase 7	2.871E−04	3.50	55.75
430750	AI650360	Hs. 100256	ESTs	1.615E−03	3.50	39.5
429301	AA449416	Hs. 31395	ESTs	6.828E−04	3.50	35
418196	AI745649	Hs. 26549	KIAA1708 protein	4.422E−02	3.50	34.5
421951	BE327432	Hs. 109804	H1 histone family, member X	2.485E−03	3.50	33.5
419825	AI754011	Hs. 7326	ESTs	6.101E−03	3.50	31.25
443303	U67319	Hs. 9216	caspase 7, apoptosis-related cysteine pr	4.604E−05	3.49	92.25
451119	AA805417	Hs. 64753	ESTs	4.088E−03	3.49	34.25
431315	AW972227	Hs. 163986	Homo sapiens cDNA: FLJ22765 fis, clone K	2.951E−05	3.49	159.25
408731	R85652		Homo sapiens mRNA; cDNA DKFZp434F1928 (f	3.690E−05	3.49	75.25
422423	AF283777	Hs. 116481	CD72 antigen	1.000E−02	3.48	39
437664	AW977714	Hs. 294139	ESTs, Moderately similar to ALU1_HUMAN A	2.497E−03	3.47	74.25
448219	AA228092		KIAA1681 protein	9.459E−04	3.47	56.5
408784	AW971350	Hs. 63386	ESTs	2.938E−05	3.47	46
417562	AW888754	Hs. 134126	crystallin, gamma S	1.926E−03	3.47	33.5
414821	M63835	Hs. 77424	Fc fragment of IgG, high affinity la, re	1.246E−02	3.47	36.5
408088	AW157022	Hs. 343551	hypothetical protein FLJ 22584	4.114E−05	3.46	32
417008	AA191708	Hs. 325825	Homo sapiens cDNA FLJ20848 fis, clone AD	2.243E−04	3.46	64.5
446238	T95143	Hs. 14511	SCO (cytochrome oxidase deficient, yeast	7.107E−05	3.45	87
446162	AI631319	Hs. 63841	hypothetical protein DKFZp434E2318	2.013E−03	3.45	41.25
453686	AL110326	Hs. 304679	ESTs, Moderately similar to Z195_HUMAN Z	1.270E−04	3.45	41.25
443242	BE243910	Hs. 9082	nucleoporin p54	6.587E−03	3.45	36
409939	AA463437	Hs. 11556	Homo sapiens cDNA FLJ12566 fis, clone NT	6.384E−05	3.45	71
418584	NM_004606	Hs. 1179	TATA box binding protein (TBP)-associate	1.241E−03	3.44	37.25
413129	AF292100	Hs. 104613	RP42 homolog	1.033E−04	3.44	106.75
416980	AA381133	Hs. 80684	high-mobility group (nonhistone chromoso	4.270E−03	3.42	67.75
450850	AA648886	Hs. 151999	ESTs	8.248E−04	3.42	55.25
426494	AL119528	Hs. 170098	KIAA0372 gene product	6.836E−03	3.42	45.5
417244	T57053	Hs. 10136	ESTs	2.711E−03	3.42	33.5
413392	AW021404	Hs. 13021	ESTs	2.827E−03	3.42	33
427722	AK000123	Hs. 180479	hypothetical protein FLJ20116	3.233E−02	3.42	32.75
441466	AW673081	Hs. 54828	ESTs	5.005E−03	3.42	32
412675	AA460716	Hs. 9788	hypothetical protein MGC10924 similar to	1.489E−02	3.41	415
439653	AW021103	Hs. 6631	hypothetical protein FLJ20373	2.954E−03	3.40	46.25
418259	AA215404		ESTs	2.628E−05	3.40	84
423032	AI684746	Hs. 119274	RAS p21 protein activator (GTPase activa	1.413E−04	3.40	71
452167	N75238	Hs. 13075	Homo sapiens cDNA: FLJ23013 fis, clone L	4.444E−03	3.40	37
408989	AW361666	Hs. 49500	KIAA0746 protein	1.662E−05	3.40	99.5
446934	AK001943	Hs. 16577	F-box only protein 3	1.768E−03	3.38	64.25
420664	AI681270	Hs. 99824	BCE-1 protein	7.518E−04	3.38	61.5
444430	AI611153	Hs. 6093	Homo sapiens cDNA: FLJ22783 fis, clone K	1.246E−02	3.38	45.25
437410	AW023340	Hs. 14880	ESTs	7.959E−03	3.38	43.25
426979	AF161472	Hs. 173074	DKFZP564O1863 protein	7.985E−03	3.38	40.75
422316	N75612	Hs. 301497	arginyltransferase 1	5.639E−03	3.38	35.75
421743	T35958	Hs. 107614	DKFZP564I1171 protein	2.346E−05	3.36	40.75
418721	NM_002731	Hs. 87773	protein kinase, cAMP-dependent, catalyti	3.687E−05	3.36	62
431742	NM_016652	Hs. 268281	crooked neck protein (crn)	4.093E−03	3.36	42.5
422473	U94780	Hs. 117242	meningioma expressed antigen 6 (coiled-c	1.417E−03	3.36	39.5
452194	AI694413	Hs. 332649	olfactory receptor, family 2, subfamily	6.214E−07	3.36	357.25
436372	AW972301	Hs. 310286	ESTs	8.217E−06	3.36	150.25
444454	BE018316	Hs. 11183	sorting nexin 2	3.489E−05	3.35	52.75
439717	W94472	Hs. 59529	ESTs, Moderately similar to ALU1_HUMAN A	5.865E−03	3.35	42.25
412634	U55984	Hs. 289088	heat shock 90 kD protein 1, alpha	5.358E−06	3.35	39
419970	AW612022	Hs. 94812	ESTs	3.201E−03	3.35	35.75
447514	AI809314	Hs. 208501	ESTs, Weakly similar to B34087 hypotheti	4.558E−02	3.35	32
444013	T08531	Hs. 44404	Homo sapiens PRO1488 mRNA, complete cds	7.116E−03	3.35	31.75
445718	H79791	Hs. 15227	ESTs	9.273E−06	3.35	156.75
437025	AW296618	Hs. 120637	ESTs	5.623E−02	3.35	30.5
425462	AI491852	Hs. 46783	Homo sapiens cDNA: FLJ22382 fis, clone H	1.657E−02	3.34	31
440726	AL050333	Hs. 7387	DKFZP564B116 protein	3.209E−03	3.34	74.25
417377	NM_016603	Hs. 82035	potential nuclear protein C5ORF5; GAP li	3.731E−06	3.34	66
452548	AL050321	Hs. 301532	CRP2 binding protein	1.919E−04	3.33	54.25
442853	AW021276	Hs. 17121	ESTs	7.401E−03	3.33	31.5
444745	AF117754	Hs. 11861	thyroid hormone receptor-associated prot	2.599E−04	3.33	90.75
438543	AA810141	Hs. 192182	ESTs	8.798E−05	3.32	59.75
447188	H65423	Hs. 17631	hypothetical protein DKFZp434E2135	5.209E−03	3.32	59.25
454064	AI130731	Hs. 57967	ESTs	7.687E−03	3.32	32.25
433269	AI343543	Hs. 126890	ESTs	3.168E−04	3.32	31.75
407813	AL120247	Hs. 40109	KIAA0872 protein	1.105E−05	3.32	66.25
452696	AI826645	Hs. 211534	ESTs	6.450E−06	3.32	55.75
430007	NM_014892	Hs. 227602	KIAA1116 protein	5.941E−04	3.32	59.75
457247	AA458605		KIAA1681 protein	7.702E−02	3.30	32.25
431451	AA761378	Hs. 192013	ESTs	5.298E−02	3.30	39.5
442160	AI337127	Hs. 156325	ESTs	7.713E−06	3.30	67.75
420962	NM_005904	Hs. 100602	MAD (mothers against decapentaplegic, Dr	9.242E−06	3.30	126.25
419284	AW820869	Hs. 215658	ESTs, Moderately similar to ZN91_HUMAN Z	5.450E−02	3.29	39.5
441297	AW403084	Hs. 7766	ubiquitin-conjugating enzyme E2E 1 (homo	7.876E−04	3.29	52
444030	AW021254	Hs. 135055	ESTs	2.194E−03	3.27	53.5
427675	AW138190	Hs. 180248	zinc finger protein 124 (HZF-16)	5.121E−05	3.27	45
408558	AW015759	Hs. 235709	Homo sapiens mRNA; cDNA DKFZp667B0711 (f	4.420E−02	3.27	37.5
418945	BE246762	Hs. 89499	arachidonale 5-lipoxygenase	1.143E−04	3.27	37
445733	BE295568	Hs. 13225	UDP-Gal: betaGlcNAc beta 1,4-galactosylt	6.592E−03	3.27	37.5
436139	AA765786	Hs. 120936	ESTs	1.033E−04	3.26	62.25
443405	AF031463	Hs. 9302	phosducin-like	1.145E−04	3.26	53.75
432841	M93425	Hs. 62	protein tyrosine phosphatase, non-recept	3.344E−03	3.26	48.5
449188	AW072939	Hs. 347187	myotubularin related protein 1	1.757E−05	3.25	59.75
441077	AI241273	H5.15312	ESTs	9.823E−07	3.25	76
442297	NM_006202	Hs. 89901	phosphodiesterase 4A, cAMP-specific (dun	1.296E−03	3.25	36.5
449439	AB029001	Hs. 23585	KIAA1078 protein	2.409E−02	3.25	33
417665	AW852858	Hs. 22862	ESTs	1.001E−02	3.25	32.75
420174	AI824144	Hs. 23912	ESTs	2.221E−05	3.25	47.75
430929	AA489166	Hs. 156933	ESTs	3.501E−04	3.22	55.5
453128	AW026516	Hs. 31791	acylphosphatase 2, muscle type	3.777E−03	3.22	46
422932	AI191813	Hs. 308220	ESTs	1.480E−03	3.22	35.25
428004	AA449563	Hs. 151393	glutamate-cysteine ligase, catalytic sub	4.844E−02	3.21	38.75
426221	AB007881	Hs. 110613	KIAA0421 protein	6.525E−04	3.21	58.5
426312	AF026939	Hs. 181874	interferon-induced protein with tetratri	1.127E−07	3.20	172.5
417678	X06560	Hs. 82396	2′,5′-oligoadenylate synthetase 1 (40-46	1.973E−07	3.20	195.5
436854	AA749167	Hs. 173911	ESTs	2.285E−03	3.20	42
418180	BE618087	Hs. 83724	hypothetical protein MGC5466	5.144E−02	3.19	31.25
414895	AW894856	Hs. 116278	Homo sapiens cDNA FLJ13571 fis, clone PL	9.877E−04	3.19	46.5
407765	AW076027	Hs. 257711	ESTs, Moderately similar to ALU8_HUMAN A	5.639E−03	3.18	57.75
448914	AI927656	Hs. 196459	ESTs	1.966E−02	3.17	45.25
447371	AA334274	Hs. 18368	DKFZP564B0769 protein	4.444E−03	3.17	41.75
439680	AW245741	Hs. 58461	ESTs, Weakly similar to A35659 krueppel-	1.036E−03	3.17	33.25
431188	W05656	Hs. 169755	ESTs	5.217E−03	3.17	32.5
446177	AK001902	Hs. 14202	hypothetical protein FLJ11040	6.019E−05	3.17	56.5
415914	AA306033	Hs. 78915	GA-binding protein transcription factor,	3.910E−02	3.17	38
408761	AA057264	Hs. 238936	ESTs, Weakly similar to (defline not ava	2.233E−04	3.17	48.25
408050	BE280478	Hs. 182695	hypothetical protein MGC3243	3.934E−03	3.16	33
444342	NM_014398	Hs. 10887	similar to lysosome-associated membrane	1.048E−07	3.15	116.75
441879	AI521936	Hs. 107149	novel protein similar to archaeal, yeast	2.630E−05	3.15	72.25
436169	AA888311	Hs. 17602	Homo sapiens cDNA FLJ12381 fis, clone MA	5.121E−05	3.15	68.5
426506	AW935187	Hs. 170162	KIAA1357 protein	5.124E−05	3.15	66.25
410390	AA876905	Hs. 125286	ESTs	4.447E−03	3.15	63.5
410614	AI091195	Hs. 65029	growth arrest-specific 1	3.559E−02	3.15	43.25
407821	AA346172	Hs. 195614	ESTs	7.489E−04	3.15	35
433364	AI075407	Hs. 296083	ESTs, Moderately similar to I54374 gene	5.558E−08	3.15	474.5
408145	AF182316	Hs. 234680	fer-1 (C. elegans)-like 3 (myoferlin)	6.880E−02	3.14	49.25
411060	NM_006074	Hs. 318501	Homo sapiens mRNA full length insert cDN	9.799E−08	3.14	238.75
421272	AA704157		ESTs	1.921E−04	3.14	46
442739	NM_007274	Hs. 8679	cytosolic acyl coenzyme A thioester hydr	6.515E−04	3.14	42.25
438021	AV653790	Hs. 324275	WW domain-containing protein 1	7.183E−04	3.13	120.25
418027	AB037807	Hs. 83293	hypothetical protein	2.632E−05	3.13	71.5
443015	R33261	Hs. 6614	ESTs, Weakly similar to A43932 mucin 2 p	1.540E−02	3.13	36.75
450374	AA397540	Hs. 60293	Homo sapiens clone 122482 unknown mRNA	2.842E−02	3.13	32.75
430068	AA464964		gb: zx80f10.s1 Soares ovary tumor NbHOT H	4.601E−05	3.12	47.75
452699	AW295390	Hs. 213062	ESTs	1.843E−03	3.11	52.25
453822	NM_014116	Hs. 35416	PRO0132 protein	7.490E−02	3.11	39
426647	AA243464	Hs. 294101	pre-B-cell leukemia transcription factor	1.084E−03	3.10	52
434629	AA789081	Hs. 4029	glioma-amplified sequence-41	1.135E−03	3.10	50.75
432680	T47364	Hs. 278613	interferon, alpha-inducible protein 27	5.551E−08	3.10	1337.75
403738			C4000675*: gi|3426332|gb|AAC32272.1|(AF0	1.571E−05	3.10	108
418627	AL079835	Hs. 86858	ribosomal protein S6 kinase, 70 kD, polyp	5.652E−04	3.09	35.5
457701	AW855466	Hs. 271866	ESTs, Weakly similar to ALU1_HUMAN ALU S	5.944E−04	3.08	55.75
458368	BE504731	Hs. 138827	ESTs	8.248E−04	3.08	64.5
449656	AA002008	Hs. 188633	ESTs	1.552E−03	3.07	72.5
448362	AA641767	Hs. 21015	hypothetical protein DKFZp564L0864 simil	1.117E−02	3.07	43.5
425815	R94023	Hs. 94560	ESTs, Moderately similar to I38022 hypot	2.127E−04	3.07	38.5
410851	AW612147	Hs. 32058	Homo sapiens C1orf19 mRNA, partial cds	4.627E−03	3.07	35.5
420258	AA477514	Hs. 96247	translin-associated factor X	1.387E−02	3.07	30.5
452253	AA928891	Hs. 28608	Homo sapiens cDNA: FLJ22115 fis, clone H	2.231E−04	3.07	42.5
417317	AW296584	Hs. 293782	ESTs	4.476E−06	3.07	78
408212	AA297567	Hs. 43728	hypothetical protein	3.326E−04	3.07	47
413278	BE563085	Hs. 833	interferon-stimulated protein, 15 kDa	5.558E−08	3.06	867.25
419257	X53461	Hs. 89781	upstream binding transcription factor, R	3.687E−05	3.05	59
424637	NM_015057	Hs. 151411	KIAA0916 protein	1.355E−06	3.05	82
414948	C15240	Hs. 182155	ESTs	2.485E−05	3.05	45.5
418677	S83308	Hs. 87224	SRY (sex determining region Y)-box 5	1.000E−02	3.05	41.25
419465	AW500239	Hs. 21187	Homo sapiens cDNA: FLJ23068 fis, clone L	1.338E−02	3.05	35.75
443787	AV646505	Hs. 122155	ESTs	2.599E−03	3.05	31.25
438980	AW502384		gb: UI-HF-BR0p-aka-f-12-0-UI.r1NIH_MGC_5	2.102E−03	3.03	59
440668	AI989538	Hs. 191074	ESTs	1.187E−03	3.03	55.25
407687	AK002011	Hs. 37558	hypothetical protein FLJ11149	7.848E−04	3.03	37.5
409977	AW805510	Hs. 97056	hypothetical protein FLJ21634	2.218E−05	3.02	74
448030	N30714	Hs. 325960	membrane-spanning 4-domains, subfamily A	2.032E−02	3.02	50.5
407705	AB023139	Hs. 37892	KIAA0922 protein	1.408E−04	3.02	49.75
450205	AI219748	Hs. 11356	ESTs	6.495E−02	3.02	47.75
437086	AW291411	Hs. 192531	ESTs, Weakly similar to S00754 zinc fing	1.827E−04	3.02	46
411960	R77776	Hs. 18103	ESTs	1.416E−03	3.02	37.25
418757	AI864193	Hs. 169728	hypothetical protein FLJ13150	6.852E−04	3.02	41.5
434045	AI065133	Hs. 152316	hypothetical protein PRO0971	4.461E−04	3.02	46.5
414617	AI339520	Hs. 288817	ESTs, Moderately similar to N Chain N, M	1.487E−05	3.02	183.25
431709	AF220185	Hs. 267923	uncharacterized hypothalamus protein HT0	2.596E−04	3.01	42.75
431341	AA307211	Hs. 251531	proteasome (prosome, macropain) subunit,	2.126E−04	3.01	60.25
409884	AI904455	Hs. 142684	hypothetical protein DKFZp667O116	3.020E−04	3.00	68
422231	AA443512	Hs. 101383	ESTs	4.601E−05	3.00	65
418460	M26315	Hs. 85258	CD8 antigen, alpha polypeptide (p32)	1.147E−04	3.00	63
446851	AW007332	Hs. 10450	Homo sapiens cDNA: FLJ22063 fis, clone H	8.341E−05	3.00	49
411127	AA668995	Hs. 218329	hypothetical protein	4.090E−03	3.00	35.5
432474	AA584042		gb: nn65e09.s1 NCI_CGAP_Lar1 Homo sapiens	1.596E−02	3.00	34.75
451171	AA248829	Hs. 112921	gb: jj6059.seq.F Human fetal heart, Lambd	9.877E−04	3.00	33.5
418182	AW016405	Hs. 16648	ESTs	1.239E−03	3.00	33
414033	AL079707	Hs. 207443	hypothetical protein MGC10848	1.930E−03	3.00	31.5
431542	H63010	Hs. 5740	ESTs	1.117E−02	3.00	31
414493	AL133921	Hs. 76272	retinoblastoma-binding protein 2	1.662E−05	2.99	90.25
428418	AI368826	Hs. 30654	ESTs	1.321E−05	2.99	85.75
431629	AU077025	Hs. 265827	interferon, alpha-inducible protein (clo	8.507E−08	2.99	674.75
439658	AA332057	Hs. 6639	hypothetical protein MGC15440	7.495E−05	2.99	47.75
425332	AA633306	Hs. 127279	ESTs	6.333E−03	2.99	40.25
410678	BE540516	Hs. 293732	hypothetical protein MGC3195	7.522E−04	2.98	54
452420	BE564871	Hs. 29463	centrin, EF-hand protein, 3 (CDC31 yeast	4.480E−06	2.97	69.75
451572	AA018556	Hs. 268691	ESTs, Moderately similar to ALU2_HUMAN A	2.219E−05	2.97	52.5
411190	AA306342	Hs. 69171	protein kinase C-like 2	8.296E−03	2.97	46
444437	AI377961	Hs. 44041	ESTs	6.592E−03	2.97	34
425548	AA890023	Hs. 1906	prolactin receptor	5.657E−04	2.97	39
413568	AA130381	Hs. 180257	ESTs	2.938E−05	2.97	45.25
419925	AA159850	Hs. 93765	lipoma HMGIC fusion partner	3.790E−02	2.97	42.75
446215	AW821329	Hs. 14368	SH3 domain binding glutamic acid-rich pr	2.391E−03	2.96	50
425907	AA365752	Hs. 155965	ESTs	3.236E−02	2.96	36.25
418679	D38552	Hs. 1191	KIAA0073 protein	4.611E−03	2.96	35.25
439776	AL360140	Hs. 176005	Homo sapiens mRNA full length insert cDN	2.008E−03	2.96	33.75
446006	NM_004403	Hs. 13530	deafness, autosomal dominant 5	5.005E−03	2.96	43.5
434822	AW076088	Hs. 4187	hypothetical protein 24636	3.115E−05	2.95	82
437275	AW976035	Hs. 292396	ESTs, Weakly similar to A47582 B-cell gr	1.084E−03	2.95	49.75
439601	AB029032	Hs. 6606	KIAA1109 protein	4.808E−03	2.95	36.25
403707			Target Exon	9.630E−03	2.95	33.75
437613	R19892	Hs. 10267	MIL1 protein	2.942E−03	2.95	30.5
458455	AV648310	Hs. 213488	ESTs	2.098E−03	2.95	46.25
450256	AA286887	Hs. 24724	MFH-amplified sequences with leucine-ric	3.687E−05	2.94	101
442053	R35343	Hs. 24968	Human DNA sequence from clone RP1-233G16	1.689E−03	2.94	50
448569	BE382657	Hs. 21486	signal transducer and activator of trans	5.551E−08	2.94	419.75
414792	BE314949	Hs. 87128	hypothetical protein FLJ23309	1.177E−06	2.93	86.25
427794	AA709186	Hs. 99070	ESTs	1.290E−02	2.93	45.25
446552	AW470827	Hs. 156241	ESTs	1.086E−04	2.92	92.5
441969	AI733386	Hs. 129194	ESTs, Weakly similar to ALU1_HUMAN ALU S	1.821E−04	2.92	65.75
451644	N23235	Hs. 30567	ESTs, Weakly similar to B34087 hypotheti	2.212E−05	2.92	52.25
423129	L44396	Hs. 124106	Homo sapiens cDNA FLJ11941 fis, clone HE	2.600E−03	2.92	46.75
418522	AA605038	Hs. 7149	Homo sapiens cDNA: FLJ21950 fis, clone H	4.043E−04	2.92	42
426279	AI648520	Hs. 169084	tubby like protein 3	1.598E−02	2.92	35.75
409444	H47933	Hs. 33983	ESTs, Weakly similar to ALU6_HUMAN ALU S	5.389E−04	2.92	33.5
445939	BE018658	Hs. 141003	Homo sapiens cDNA: FLJ21691 fis, clone C	4.991E−02	2.92	32
417788	AI436699	Hs. 84928	nuclear transcription factor Y, beta	1.116E−02	2.92	30
415023	AA932146	Hs. 133494	Homo sapiens clone TCCCIA00164 mRNA sequ	4.037E−04	2.92	38
452866	R26969	Hs. 268016	Homo sapiens cDNA: FLJ21243 fis, clone C	1.845E−03	2.92	50.5
457000	NM_006750	Hs. 172278	syntrophin, beta 2 (dystrophin-associate	5.420E−03	2.92	30.25
423568	NM_005256	Hs. 129818	growth arrest-specific 2	2.024E−04	2.92	84
454000	AA040620	Hs. 5672	hypothetical protein AF140225	1.078E−02	2.92	75.25
409600	AJ011679	Hs. 55099	rab6 GTPase activating protein (GAP and	2.212E−05	2.91	56
432451	AW972771	Hs. 292471	ESTs, Weakly similar to ALU1_HUMAN ALU S	3.668E−02	2.91	38.75
419126	AI810144	Hs. 135276	ESTs	6.101E−03	2.91	35.75
428974	AA442693	Hs. 272006	ESTs, Weakly similar to I38022 hypotheti	7.753E−06	2.90	100
440945	AW505345	Hs. 7540	f-box and leucine-rich repeat protein 3A	5.624E−02	2.90	53.25
439024	R96696	Hs. 35598	ESTs	2.750E−02	2.90	91.25
426126	AL118747	Hs. 26691	ESTs	3.163E−04	2.90	57
428738	NM_000380	Hs. 192803	xeroderma pigmentosum, complementation g	3.499E−04	2.90	56.25
403743			C1002604: gi|8393668|ref|NP_058989.1|kin	7.116E−03	2.90	49.25
437108	AA434054	Hs. 80624	hypothetical protein MGC2560	5.406E−03	2.90	47.5
407816	AW500857	Hs. 40137	anaphase-promoting complex 1; meiotic ch	1.969E−02	2.90	47.5
420683	AA830168	Hs. 271305	ESTs	1.481E−03	2.90	42.75
414429	R51494	Hs. 71818	ESTs	1.903E−02	2.90	37.25
426590	AA617830	Hs. 28310	ESTs	3.777E−03	2.90	34.75
408138	AA535740	Hs. 170263	tumor protein p53-binding protein, 1	7.123E−03	2.90	32.75
437151	AA745618		BANP homolog, SMAR1 homolog	6.130E−02	2.89	35.5
418729	AB028449	Hs. 87889	helicase-moi	1.032E−04	2.89	65.25
447002	BE242866	Hs. 16933	HepA-related protein	9.175E−07	2.88	51.25
451582	AI963026	Hs. 289958	ESTs, Weakly similar to putative p150 [H	9.642E−03	2.88	49.25
456804	AI421645	Hs. 139851	caveolin 2	3.448E−02	2.88	50.5
428695	AI355647	Hs. 189999	purinergic receptor (family A group 5)	6.035E−05	2.88	42.5
418248	NM_005000	Hs. 83916	NM_005000*: Homo sapiens NADH dehydrogena	3.032E−02	2.86	48
427547	BE047653	Hs. 119183	ESTs, Weakly similar to ZN91_HUMAN ZINC	1.034E−03	2.86	47
409509	AL036923	Hs. 322710	ESTs	9.289E−03	2.86	52.5
421718	AL117574		Homo sapiens mRNA; cDNA DKFZp434L2221 (f	3.120E−05	2.85	60.75
419438	AA406400	Hs. 12482	glyceronephosphate O-acyltransferase	7.982E−03	2.85	38
412019	AA485890	Hs. 69330	Homo sapiens cDNA FLJ13835 fis, clone TH	3.895E−05	2.85	65.75
427704	AW971063	Hs. 292882	ESTs	4.162E−02	2.85	78.25
422607	Z45471	Hs. 118684	stromal cell-derived factor 2	1.086E−04	2.85	65.25
403330			Target Exon	3.674E−04	2.85	74.5
430280	AA361258	Hs. 237868	interleukin 7 receptor	2.353E−04	2.85	80.75
436100	AA704806	Hs. 143842	ESTs, Weakly similar to 2004399A chromos	3.034E−02	2.85	54.5
453041	AI680737	Hs. 289068	Homo sapiens cDNA FLJ11918 fis, clone HE	5.421E−03	2.84	53
408527	AL135018	Hs. 33074	Homo sapiens, clone IMAGE: 3606519, mRNA,	8.617E−03	2.83	42.5
429503	AA394183	Hs. 26873	ESTs	1.693E−03	2.82	42.25
445564	AB028957	Hs. 12896	KIAA1034 protein	5.859E−03	2.82	41.5
401197			ENSP00000229263*: HSPC213.	3.234E−02	2.82	40.5
409205	AI952884	Hs. 14832	ESTs, Moderately similar to unnamed prot	3.937E−03	2.82	38.5
443280	AA299688	Hs. 24183	ESTs	2.494E−03	2.82	41.5
408411	C15118	Hs. 322482	hypothetical protein DKFZp566J2046	1.546E−06	2.82	115
417831	H16423	Hs. 82685	CD47 antigen (Rh-related antigen, integr	3.330E−04	2.81	58.5
433483	AI926520	Hs. 31016	putative DNA binding protein	1.902E−02	2.81	33
433902	AW292820	Hs. 144906	ESTs	6.835E−04	2.81	49.25
409132	AJ224538	Hs. 50732	protein kinase, AMP-activated, beta 2 no	3.408E−07	2.81	137.25
431976	AA719001	Hs. 291065	ESTs	8.638E−04	2.80	43.25
425836	AW955696	Hs. 90960	ESTs	9.808E−06	2.80	57.5
439773	AI051313	Hs. 143315	ESTs	3.918E−03	2.80	37
427399	NM_014883	Hs. 177664	KIAA0914 gene product	1.085E−03	2.80	84.5
420985	X94703		RAB28, member RAS oncogene family	1.925E−03	2.79	39
410800	BE280421	Hs. 94499	ESTs	2.227E−04	2.79	56
418549	AA927177	Hs. 86041	CGG triplet repeat binding protein 1	4.244E−04	2.79	53.75
420339	AW968259	Hs. 186647	ESTs	1.399E−05	2.79	73
443352	H70284	Hs. 160152	ESTs, Weakly similar to FPHU alpha-fetop	1.186E−03	2.79	40.75
417018	M16038	Hs. 80887	v-yes-1 Yamaguchi sarcoma viral related	1.542E−02	2.79	59.5
423067	AA321355	Hs. 285401	colony stimulating factor 2 receptor, be	2.710E−03	2.79	34
458971	AL119206	Hs. 126257	ESTs, Weakly similar to ALU1_HUMAN ALU S	4.816E−03	2.79	77.25
438493	AI130740	Hs. 6241	phosphoinositide-3-kinase, regulatory su	4.492E−06	2.79	149.5
424755	AB033094	Hs. 152925	KIAA1268 protein	3.619E−07	2.78	83
436562	H71937	Hs. 322904	ESTs, Weakly similar to I38022 hypotheti	4.099E−03	2.78	95
421662	NM_014141	Hs. 106552	cell recognition molecule Caspr2	1.133E−03	2.78	38.25
408190	AB032963	Hs. 43577	ATPase, Class I, type 8B, member 2	7.488E−02	2.77	37.25
434500	AF143877	Hs. 215047	Homo sapiens clone IMAGE: 113431 mRNA seq	1.159E−02	2.77	34.5
445044	AL137728	Hs. 12258	Homo sapiens mRNA; cDNA DKFZp434B0920 (f	5.012E−03	2.77	43.25
429312	AL133572	Hs. 199009	protein containing CXXC domain 2	2.948E−03	2.76	34.75
445106	T10219	Hs. 12329	KIAA0697 protein	3.330E−04	2.76	61
450919	AA011616	Hs. 269877	ESTs	4.466E−04	2.75	50
435767	H73505	Hs. 117874	ESTs	7.701E−02	2.75	61.75
435872	AA701357	Hs. 192759	ESTs	8.827E−05	2.75	128.25
434521	NM_002267	Hs. 3886	karyopherin alpha 3 (importin alpha 4)	6.838E−04	2.75	74
432134	AI816782	Hs. 122583	hypothetical protein FLJ21934	6.838E−04	2.75	59.75
452057	AW952005	Hs. 14928	hypothetical protein FLJ12903	2.353E−04	2.75	45.25
424381	AA285249	Hs. 146329	protein kinase Chk2	1.969E−02	2.75	44.75
434963	AW974957	Hs. 288719	Homo sapiens cDNA FLJ12142 fis, clone MA	4.260E−03	2.75	43.75
411352	NM_002890	Hs. 758	RAS p21 protein activator (GTPase activa	1.037E−03	2.75	43
426416	AW612744	Hs. 169824	killer cell lectin-like receptor subfami	6.555E−03	2.75	41
449259	AW452058	Hs. 257519	ESTs	5.652E−04	2.75	40.25
436184	BE154067	Hs. 136660	ESTs, Weakly similar to ZN91_HUMAN ZINC	9.624E−03	2.75	40.25
439605	AF086431	Hs. 22380	ESTs	5.206E−03	2.75	34.75
404676			Target Exon	2.577E−02	2.75	30.75
443154	H04360	Hs. 24283	ESTs, Moderately similar to reduced expr	2.599E−03	2.75	48.5
440538	W76332	Hs. 79107	mitogen-activated protein kinase 14	4.096E−03	2.74	31.75
413823	AI341417	Hs. 29406	ESTs	3.893E−07	2.74	78.25
413880	AI660842	Hs. 110915	interleukin 22 receptor	5.412E−05	2.73	63.25
409005	AW299806	Hs. 297256	ESTs	6.345E−03	2.73	37.25
423706	U95218	Hs. 131924	G protein-coupled receptor 65	7.848E−04	2.73	40.25
433745	AF075320	Hs. 28980	hypothetical protein FLJ14540	4.629E−03	2.73	38.5
459436	AA323121		gb: EST25881 Cerebellum II Homo sapiens c	1.298E−03	2.73	41.5
415668	AW957684	Hs. 306814	hypothetical protein FLJ21889	2.664E−02	2.73	65.25
439462	AL133026	Hs. 6567	Homo sapiens mRNA; cDNA DKFZp436C136 (fr	2.006E−03	2.72	34
436741	AA860163	Hs. 291319	ESTs	8.293E−03	2.72	33.5
422722	H74219	Hs. 269772	ESTs	9.896E−04	2.72	40
447030	AW444659	Hs. 232184	ESTs	5.005E−03	2.71	30.75
446217	AI651594	Hs. 99709	ESTs	1.714E−07	2.70	116.25
413838	AV661185	Hs. 75574	mitochondrial ribosomal protein L19	5.669E−04	2.70	44.25
445715	AB012958	Hs. 13137	UV radiation resistance associated gene	1.087E−04	2.70	54.75
411213	AA676939	Hs. 69285	neuropilin 1	3.341E−03	2.70	53.75
412935	BE267045	Hs. 75064	tubulin-specific chaperone c	1.090E−04	2.70	47.75
408051	AI623351	Hs. 172148	ESTs	3.449E−02	2.70	41.75
457650	AA649162	Hs. 236456	ESTs	1.107E−05	2.69	80.25
422461	NM_003417	Hs. 117077	zinc finger protein 264	7.112E−04	2.69	33.75
421524	AA312082	Hs. 105445	GDNF family receptor alpha 1	1.572E−05	2.68	72
453779	N35187	Hs. 43388	28 kD interferon responsive protein	9.788E−08	2.68	183
425284	AF155568	Hs. 348043	NS1-associated protein 1	2.470E−04	2.68	44.5
451107	AA235108		Homo sapiens ubiquitin protein ligase (U	1.976E−05	2.68	45.75
443849	BE566066	Hs. 9893	ASB-3 protein	6.219E−04	2.68	48.25
438182	AW342140	Hs. 182545	ESTs, Weakly similar to ALU1_HUMAN ALU S	7.507E−04	2.67	47
433312	AI241331	Hs. 131765	ESTs, Moderately similar to I38937 DNA/R	1.822E−04	2.67	44.5
437838	AI307229	Hs. 184304	ESTs	2.389E−03	2.67	43.75
426797	AW936258	Hs. 342849	ADP-ribosylation factor-like 5	3.447E−02	2.67	39.25
430594	AK000790	Hs. 246885	hypothetical protein FLJ20783	1.713E−02	2.67	31
429245	AW969785	Hs. 285885	Homo sapiens cDNA FLJ11321 fis, clone PL	2.180E−02	2.67	30.75
407796	AA195509	Hs. 39733	postsynaptic protein CRIPT	9.005E−04	2.67	39.75
421939	BE169531	Hs. 109727	TAK1-binding protein 2; KIAA0733 protein	9.459E−04	2.67	83.25
429623	NM_005308	Hs. 211569	G protein-coupled receptor kinase 5	4.267E−03	2.67	62.75
432485	N90866	Hs. 276770	CDW52 antigen (CAMPATH-1 antigen)	2.966E−07	2.67	203
451690	AW451469	Hs. 209990	ESTs	2.664E−02	2.67	36.75
411777	BE067552		gb: MR4-BT0358-020200-002-g10 BT0358 Homo	1.338E−02	2.67	43.75
420623	BE245485	Hs. 99437	Homo sapiens mRNA; cDNA DKFZp586G1924 (f	2.015E−03	2.66	48.25
450607	AL050373	Hs. 25213	hypothetical protein	3.968E−06	2.66	128.5
428466	AF151063	Hs. 184456	hypothetical protein	1.928E−03	2.66	42
424321	W74048	Hs. 1765	lymphocyte-specific protein tyrosine kin	3.892E−05	2.66	71.5
411943	BE502436	Hs. 7962	ESTs, Weakly similar to S44608 C02F5.6 p	8.939E−03	2.66	34.5
409161	W07662	Hs. 50861	sirtuin (silent mating type information	1.395E−05	2.66	45.25
407908	BE379758	Hs. 110853	uncharacterized hematopoietic stem/proge	4.698E−02	2.66	37.75
444057	AA316896	Hs. 257267	FYVE and coiled-coil domain containing 1	1.487E−04	2.66	56
419216	AU076718	Hs. 164021	small inducible cytokine subfamily B (Cy	2.333E−02	2.66	36.5
427297	AW292593	Hs. 334907	Homo sapiens, clone MGC: 17333, mRNA, com	7.913E−05	2.66	90.25
446783	AW138343	Hs. 141867	ESTs	3.076E−03	2.66	36
427528	AU077143	Hs. 179565	minichromosome maintenance deficient (S.	7.282E−06	2.65	64.75
446830	BE179030	Hs. 239307	Human DNA sequence from clone RP5-1174N9	2.019E−04	2.65	47.5
440529	AW207640	Hs. 16478	Homo sapiens cDNA: FLJ21718 fis, clone C	5.403E−04	2.65	40.5
434821	AA159111	Hs. 284281	Human putative ribosomal protein S1 mRNA	2.483E−05	2.65	50.25
437830	AB020658	Hs. 5867	KIAA0851 protein; suppressor of actin 1	1.617E−03	2.65	58
418832	X04011	Hs. 88974	cytochrome b-245, beta polypeptide (chro	6.389E−05	2.64	56.25
445652	AL117473	Hs. 13036	DKFZP727A071 protein	7.158E−04	2.64	39
447387	AI268331	Hs. 102237	tubby super-family protein	7.552E−07	2.64	67.25
453315	BE544203	Hs. 24831	ESTs	3.624E−03	2.64	41.75
425266	J00077	Hs. 155421	alpha-fetoprotein	3.338E−03	2.64	43.75
414602	AW630088	Hs. 76550	Homo sapiens mRNA; cDNA DKFZp564B1264 (f	1.652E−04	2.63	86.5
436235	AI084982	Hs. 120790	ESTs	2.470E−04	2.63	36.25
430027	AB023197	Hs. 227743	KIAA0980 protein	9.843E−07	2.63	78.5
440528	BE313555	Hs. 7252	KIAA1224 protein	2.713E−03	2.63	50
403976			Target Exon	4.265E−03	2.63	49.75
447657	AI953011	Hs. 345287	ESTs	5.146E−04	2.63	34.75
412230	AI810374	Hs. 124177	ESTs, Weakly similar to 2109260A B cell	1.925E−03	2.62	31.25
407804	AF228603	Hs. 39957	pleckstrin 2 (mouse) homolog	5.947E−04	2.62	61.25
410853	H04588	Hs. 30469	ESTs	6.105E−03	2.62	76.5
416611	AA568308		ESTs, Weakly similar to ALU6_HUMAN ALU S	5.669E−04	2.62	49.75
452207	NM_014517	Hs. 28423	upstream binding protein 1 (LBP-1a)	1.037E−05	2.62	76.75
435445	AA737345	Hs. 294041	ESTs	2.706E−03	2.61	35.5
434608	AA805443	Hs. 179909	hypothetical protein FLJ22995	1.133E−03	2.61	50
420058	AK001423	Hs. 94694	Homo sapiens cDNA FLJ10561 fis, clone NT	6.456E−06	2.61	79.75
447769	AW873704	Hs. 320831	Homo sapiens cDNA FLJ14597 fis, clone NT	4.253E−04	2.61	47.5
438441	AW664960	Hs. 205319	ESTs	2.024E−04	2.61	66
448770	AA326683	Hs. 21992	likely ortholog of mouse variant polyade	2.860E−04	2.61	69.5
431899	AA521381	Hs. 187726	ESTs	4.627E−03	2.61	37.75
449082	BE387561	Hs. 22981	DKFZP586M1523 protein	2.340E−04	2.60	52.5
449881	Z28444	Hs. 24119	Homo sapiens mRNA; cDNA DKFZp586G2222 (f	9.477E−04	2.60	66.5
433913	AI694106	Hs. 72325	ESTs, Weakly similar to I38022 hypotheti	6.131E−02	2.60	43.25
442432	BE093589	Hs. 38178	hypothetical protein FLJ23468	1.031E−04	2.60	76.25
425118	AU076611	Hs. 154672	methylene tetrahydrofolate dehydrogenase	3.205E−03	2.60	59.25
422283	AW411307	Hs. 114311	CDC45 (cell division cycle 45, S.cerevis	1.561E−04	2.60	45.25
412520	AA442324	Hs. 795	H2A histone family, member O	1.669E−05	2.60	95.5
411580	AL080088	Hs. 70877	DKFZP564K2062 protein	7.455E−05	2.60	42.75
431562	AI884334	Hs. 11637	ESTs	9.075E−02	2.59	48.5
419426	AI214690	Hs. 346257	aldo-keto reductase family 1, member B1	2.462E−04	2.59	48
422241	Y00062	Hs. 170121	protein tyrosine phosphatase, receptor t	3.968E−06	2.58	129
401928			Target Exon	4.841E−02	2.57	32
427130	AB029020	Hs. 173694	KIAA1097 protein	9.832E−06	2.57	66.5
409614	BE297412	Hs. 55189	hypothetical protein	9.799E−08	2.57	161.5
448873	NM_003677	Hs. 22393	density-regulated protein	3.845E−04	2.56	40.25
413305	NM_000426	Hs. 323511	Homo sapiens cDNA: FLJ23176 fis, clone L	1.835E−02	2.56	43.75
446771	AA128965	Hs. 60679	TATA box binding protein (TBP)-associate	1.873E−05	2.56	78.5
422392	NM_005908	Hs. 115945	mannosidase, beta A, lysosomal	1.898E−02	2.56	30
423968	AF098277	Hs. 136529	solute carrier family 23 (nucleobase tra	1.648E−06	2.55	74.25
418941	AA452970	Hs. 239527	E1B-55 kDa-associated protein 5	3.034E−02	2.55	56.75
434669	AF151534	Hs. 92023	core histone macroH2A2.2	2.738E−06	2.55	119.25
432476	T94344	Hs. 326263	ESTs	1.691E−03	2.55	93.5
452748	AB011128	Hs. 30512	Homo sapiens mRNA for KIAA0556 protein,	7.507E−04	2.55	46.5
445757	AW449065	Hs. 13264	KIAA0856 protein	8.934E−03	2.55	44.25
434948	AI498469	Hs. 12622	ESTs, Highly similar to AF161436 1 HSPC3	2.011E−03	2.55	40
439372	AF088033	Hs. 159225	ESTs	1.200E−02	2.55	35.5
448888	AW196663	Hs. 200242	caspase recruitment domain protein 6	1.915E−04	2.55	40.25
417821	BE245149	Hs. 82643	protein tyrosine kinase 9	7.985E−03	2.54	66
415000	AW025529	Hs. 239812	Homo sapiens serologically defined breas	4.108E−05	2.54	74.75
417558	AF045229	Hs. 82280	regulator of G-protein signalling 10	1.338E−02	2.54	37.75
418796	AA228351	Hs. 34060	ESTs	1.815E−04	2.54	38.5
450196	AW956868	Hs. 24608	DKFZP564D177 protein	1.175E−05	2.54	138.5
422043	AL133649	Hs. 110953	retinoic acid induced 1	3.856E−04	2.54	51.5
428985	AL134193	Hs. 194709	paraneoplastic antigen MA1	1.298E−03	2.53	42.5
411196	W31212	Hs. 69192	vacuolar protein sorting 29 (yeast homol	1.439E−02	2.53	41.25
427094	AB025254	Hs. 283761	tudor repeat associator with PCTAIRE 2	2.092E−07	2.53	90.5
452737	AK001680	Hs. 30488	DKFZP434F091 protein	2.090E−03	2.52	30.5
407355	AA846203	Hs. 193974	ESTs, Weakly similar to ALU1_HUMAN ALU S	9.360E−04	2.52	30.5
431374	BE258532	Hs. 251871	CTP synthase	6.831E−04	2.52	72.75
427647	W19744	Hs. 180059	Homo sapiens cDNA FLJ20653 fis, clone KA	3.898E−05	2.52	73.5
407436	AF211977		gb: Homo sapiens LENG10 mRNA, partial seq	1.437E−02	2.52	30
437145	AF007216	Hs. 5462	solute carrier family 4, sodium bicarbon	1.134E−03	2.52	73.25
421446	AA682425	Hs. 118959	ESTs	1.774E−02	2.52	32.25
458079	AI796870	Hs. 54277	DNA segment on chromosome X (unique) 992	3.091E−06	2.52	130.5
424375	AF070547	Hs. 146312	Homo sapiens clone 24820 mRNA sequence	4.423E−02	2.51	31
428727	AF078847	Hs. 191356	general transcription factor IIH, polype	9.891E−04	2.51	63.25
421405	AA251944	Hs. 104058	CGI-29 protein	1.567E−04	2.51	74.5
418733	AA227714	Hs. 179703	KIAA0129 gene product	1.650E−04	2.50	56
447225	R62676	Hs. 17820	Rho-associated, coiled-coil containing p	4.611E−05	2.50	95.75
433162	AI025842	Hs. 152530	ESTs	5.424E−05	2.50	102.75
423645	AI215632	Hs. 147487	ESTs	1.736E−04	2.50	56.75
446045	AV656268	Hs. 209153	angiopoietin-like 3	2.239E−04	2.50	56.25
430273	AI311127	Hs. 125522	ESTs	9.035E−04	2.50	46
401898			NM_024722*: Homo sapiens hypothetical pro	1.927E−03	2.50	45
427210	BE396283	Hs. 173987	eukaryotic translation initiation factor	6.852E−03	2.50	44.25
445664	AW968638	Hs. 237691	ESTs, Weakly similar to KIAA0601 protein	7.093E−05	2.50	39.25
422195	AB007903	Hs. 113082	KIAA0443 gene product	6.581E−03	2.50	33
423069	W15613	Hs. 1613	adenosine A2a receptor	5.618E−02	2.50	30.25
417928	AA209344	Hs. 30177	ESTs	2.878E−04	2.49	68.5
448717	R67419	Hs. 21851	Homo sapiens cDNA FLJ12900 fis, clone NT	4.097E−03	2.49	50.25
433000	U26710	Hs. 3144	Cas-Br-M (murine) ectropic retroviral tr	2.036E−02	2.48	44.75
426011	AW996096	Hs. 58924	ESTs, Weakly similar to JC5594 jerky gen	5.152E−04	2.48	45.75
407112	AA070801	Hs. 51615	ESTs, Weakly similar to ALU7_HUMAN ALU S	3.450E−02	2.47	106.75
410196	AI936442	Hs. 59838	hypothetical protein FLJ10808	4.868E−05	2.47	65.5
430487	D87742	Hs. 241552	KIAA0268 protein	2.235E−04	2.47	43.5
427254	AL121523	Hs. 97774	ESTs	4.813E−03	2.47	36.5
452480	AI903526		gb: RC-BT031-090199-063 BT031 Homo sapien	4.994E−02	2.47	31.75
403027			C21000364*: gi|8394509|ref|NP_058778.1| u	2.380E−03	2.47	34.25
414760	BE298063	Hs. 77254	chromobox homolog 1 (Drosophila HP1 beta	5.090E−07	2.47	79.5
444931	AV652066	Hs. 75113	general transcription factor IIIA	7.180E−04	2.47	70.5
437708	AB033020	Hs. 5801	KIAA1194 protein	8.210E−06	2.47	64.25
440340	AW895503	Hs. 125276	ESTs	8.596E−03	2.47	33.75
448198	BE622100	Hs. 209406	ESTs, Weakly similar to I38600 zinc fing	2.871E−04	2.46	43.75
405689			NM_018850*: Homo sapiens ATP-binding cass	5.010E−03	2.46	133
418203	X54942	Hs. 83758	CDC28 protein kinase 2	1.692E−03	2.45	50.25
449239	T24653	Hs. 23360	likely ortholog of yeast ARV1	1.272E−06	2.45	46.5
434128	W93170	Hs. 284164	protein x 0004	2.354E−04	2.45	41
416354	NM_000633	Hs. 79241	B-cell CLL/lymphoma 2	5.720E−05	2.45	40
438141	AW946871		gb: RC2-ET0022-080500-012-d02 ET0022 Homo	1.547E−03	2.45	33.5
423983	AA333261		gb: EST37476 Embryo, 8 week I Homo sapien	2.578E−02	2.45	31.25
438922	R71288	Hs. 259664	ESTs	5.297E−02	2.45	31.5
426295	AW367283	Hs. 278270	zinc finger protein 6 (CMPX1)	3.307E−05	2.45	169.5
420936	AA456112	Hs. 99410	ESTs	6.341E−03	2.45	36.5
438475	W03856	Hs. 13188	ESTs, Highly similar to Gene product wit	1.714E−07	2.44	157.5
446487	AA195526	Hs. 44625	Rad50-interacting protein 1	2.288E−03	2.44	32.5
450253	AL133047	Hs. 24715	Homo sapiens mRNA; cDNA DKFZp434D0215 (f	4.265E−03	2.44	62
421999	U50535	Hs. 110630	Human BRCA2 region, mRNA sequence CG006	3.673E−02	2.44	73.5
442643	U82756	Hs. 3991	PRP4/STK/WD splicing factor	4.032E−02	2.44	32.75
427156	BE621719	Hs. 173802	KIAA0603 gene product	2.841E−02	2.43	54.5
433201	AB040896	Hs. 21104	KIAA1463 protein	2.098E−03	2.43	45.75
442149	AB014550	Hs. 8118	KIAA0650 protein	2.829E−03	2.42	52.25
436021	R26877	Hs. 24128	ESTs	5.639E−03	2.42	38.5
451099	R52795	Hs. 25954	interleukin 13 receptor, alpha 2	4.993E−02	2.42	52
430526	AF181862	Hs. 242407	G protein-coupled receptor, family C, gr	4.126E−05	2.42	101.25
414404	W16712	Hs. 306117	KIAA0306 protein	9.266E−05	2.42	94
410664	NM_006033	Hs. 65370	lipase, endothelial	2.192E−03	2.42	57
436643	AA757626	Hs. 10941	ESTs, Weakly similar to IPP1_HUMAN PROTE	2.235E−04	2.41	65.75
418780	AA228078	Hs. 255096	ESTs	2.829E−03	2.41	41
427468	AB036829	Hs. 178347	SKIP for skeletal muscle and kidney enri	2.122E−04	2.41	41
437143	AW204056	Hs. 8917	ESTs	1.969E−07	2.41	124.75
439747	AK001148	Hs. 6671	COP9 complex subunit 4	2.349E−04	2.41	53
447881	BE620886	Hs. 75354	GCN1 (general control of amino-acid synt	4.442E−03	2.41	54
443562	AF118838	Hs. 9599	solute carrier family 25, member 13 (cit	5.142E−02	2.41	53.25
448280	AW014215	Hs. 357	zinc finger protein 134 (clone pHZ-15)	9.001E−04	2.41	37
439645	BE091801	Hs. 27167	ESTs, Weakly similar to I38022 hypotheti	5.430E−07	2.41	71.5
427657	AV652249	Hs. 180107	polymerase (DNA directed), beta	2.417E−07	2.41	116.5
412977	AA125910	Hs. 191461	ESTs	6.492E−04	2.41	55.25
450203	AF097994	Hs. 301528	L-kynurenine/alpha-aminoadipate aminotra	5.298E−02	2.40	47.75
417089	H52280	Hs. 18612	Homo sapiens cDNA: FLJ21909 fis, clone H	1.131E−07	2.40	155.5
446044	H67567	Hs. 13572	calcium modulating ligand	6.632E−07	2.40	91
444088	AW297946	Hs. 138208	ESTs	3.911E−02	2.40	40.5
449118	R67477	Hs. 23103	Bet1 (S. cerevisiae) homolog	7.679E−03	2.40	39.25
441488	AW450935	Hs. 7862	hypothetical protein FLJ20312	1.044E−05	2.40	102.25
424088	AL049942	Hs. 139240	DKFZP564F1422 protein	3.007E−04	2.39	42.5
444755	AA431791	Hs. 113823	CIpX (caseinolytic protease X, E. coli)	2.406E−02	2.39	33
439768	AI337300	Hs. 173138	hypothetical protein MGC4604	1.541E−06	2.39	98.5
427985	AI770170	Hs. 29643	Homo sapiens cDNA FLJ13103 fis, clone NT	4.814E−03	2.39	42.25
448646	AU077149	Hs. 21704	transcription factor 12 (HTF4, helix-loo	3.170E−04	2.38	83.75
449845	AW971183	Hs. 9683	DnaJ (Hsp40) homolog, subfamily C, membe	1.829E−04	2.38	111
451578	NM_016323	Hs. 26663	cyclin-E binding protein 1	3.893E−07	2.38	146.25
446570	AV659177	Hs. 127160	ESTs	1.399E−05	2.38	79.5
430532	D61216	Hs. 18672	ESTs	1.599E−02	2.38	35.25
418822	Z43371	Hs. 7012	ESTs	5.219E−03	2.38	40.75
446507	AA352554	Hs. 15164	nuclear DNA-binding protein	3.630E−03	2.38	58
419203	AA488719	Hs. 190151	ESTs	2.387E−03	2.38	56.25
435427	AA682573	Hs. 188982	ESTs, Weakly similar to organic anion tr	2.012E−03	2.38	73.5
444372	AW377983	Hs. 298140	Homo sapiens cDNA: FLJ22502 fis, clone H	1.269E−04	2.38	31
414496	W73853		ESTs	8.625E−04	2.38	73
430219	X99209	Hs. 235887	HMT1 (hnRNP methyltransferase, S. cerevi	2.494E−02	2.38	42
447211	AL161961	Hs. 17767	KIAA1554 protein	1.716E−07	2.38	143.5
427020	AA397546	Hs. 119151	ESTs	2.493E−03	2.38	35.25
425375	AA631977	Hs. 155995	KIAA0643 protein	1.240E−05	2.38	34.25
440341	AW664012	Hs. 132333	ESTs	6.525E−04	2.38	30.25
418300	AI433074	Hs. 86682	Homo sapiens cDNA: FLJ21578 fis, clone C	3.787E−02	2.38	30.25
429978	AA249027		ribosomal protein S6	2.953E−03	2.37	85.25
422614	AI908006	Hs. 295362	Homo sapiens cDNA FLJ14459 fis, clone HE	5.423E−03	2.37	35.25
447279	AA325308	Hs. 18016	Homo sapiens mRNA; cDNA DKFZp586H0324 (f	1.694E−03	2.37	47.5
420613	AI873871	Hs. 122444	ESTs, Weakly similar to A47582 B-cell gr	4.453E−07	2.37	89.5
408521	AA055264	Hs. 260848	ESTs, Weakly similar to S23650 retroviru	1.971E−05	2.37	44.75
429617	X89984	Hs. 211563	B-cell CLL/lymphoma 7A	3.335E−03	2.36	30
414172	AW954324	Hs. 75790	phosphatidylinositol glycan, class C	8.270E−03	2.36	31
418416	U11700	Hs. 84999	ATPase, Cu transporting, beta polypeptid	1.764E−05	2.36	59.25
446071	N51527	Hs. 13659	hypothetical protein DKFZp586F2423	8.224E−06	2.36	102.75
451743	AW074266	Hs. 23071	ESTs	9.290E−05	2.36	56.25
437134	AA349944	Hs. 42915	ARP2 (actin-related protein 2, yeast) ho	1.199E−02	2.36	51.5
410612	AW502698	Hs. 118152	ESTs	3.734E−06	2.35	117.5
442439	U09759	Hs. 246857	mitogen-activated protein kinase 9	7.907E−05	2.35	70
439103	AF085959	Hs. 38705	ESTs	1.616E−03	2.35	41.5
427469	AA403084	Hs. 269347	ESTs, Weakly similar to 2109260A B cell	4.093E−03	2.35	40.75
428044	AA093322	Hs. 301404	RNA binding motif protein 3	6.130E−02	2.35	35.75
420137	AA306478	Hs. 95327	CD3D antigen, delta polypeptide (TiT3 co	2.255E−06	2.35	78.5
446594	AI311917	Hs. 16292	ESTs	5.144E−02	2.35	71.75
452685	AI634651	Hs. 30250	v-maf musculoaponeurotic fibrosarcoma (a	7.085E−07	2.34	145.75
439708	AI761369	Hs. 59584	hypothetical protein FLJ21144	1.735E−04	2.34	36.5
451589	AA424791	Hs. 5734	meningioma expressed antigen 5 (hyaluron	3.852E−04	2.33	57
414312	AA155694	Hs. 191060	ESTs	7.918E−05	2.32	54.75
439556	AI623752	Hs. 163603	ESTs	4.627E−03	2.32	45.5
421025	AW958975	Hs. 29397	Homo sapiens cDNA FLJ13226 fis, clone OV	5.395E−04	2.32	37
435919	AI052189	Hs. 114104	ESTs	5.010E−03	2.32	30.75
408931	AA251995	Hs. 334648	poly(A) polymerase alpha	2.841E−02	2.32	37.25
438000	AI825880	Hs. 5985	non-kinase Cdc42 effector protein SPEC2	6.103E−03	2.32	72.5
402041			C15001201*: gi|6841178|gb|AAF28942.1|AF16	1.687E−03	2.32	40.5
437223	C15105	Hs. 330716	Homo sapiens cDNA FLJ14368 fis, clone HE	8.248E−04	2.31	95.25
420717	AA284447	Hs. 271887	ESTs	7.277E−02	2.31	41
408340	AB037762	Hs. 44268	myelin gene expression factor 2	5.994E−05	2.31	39
452248	AA093668	Hs. 28578	muscleblind (Drosophila)-like	2.634E−05	2.31	62.25
436252	AI539519	Hs. 120969	Homo sapiens cDNA FLJ11562 fis, clone HE	5.406E−04	2.31	70
420825	AI656727		gb: tt53f12.x1 NCI_CGAP_GC6 Homo sapiens	7.165E−04	2.31	42.5
442831	AI798959	Hs. 131686	ESTs	7.169E−04	2.31	76.75
407970	AW403814	Hs. 41714	BCL2-associated athanogene	1.038E−02	2.30	30
410726	AI623859	Hs. 15936	ESTs	2.595E−04	2.30	33.25
437109	AW006781	Hs. 5457	hypothetical protein FLJ10738	1.732E−04	2.30	45.25
415662	AW972481	Hs. 170610	ESTs, Highly similar to G01887 MEK kinas	6.380E−05	2.30	76.5
425913	AA365799	Hs. 50785	SEC22, vesicle trafficking protein (S. c	6.393E−05	2.30	79.75
410017	AW952426	Hs. 109438	Homo sapiens clone 24775 mRNA sequence	1.089E−04	2.30	82.25
422900	M641201	Hs. 222051	ESTs	5.657E−04	2.30	54.75
420164	AW339037	Hs. 24908	ESTs	2.491E−02	2.30	33.75
413029	AL119399	Hs. 293850	ESTs	2.764E−05	2.30	44.5
457605	AV657778	Hs. 3314	selenoprotein P, plasma, 1	7.165E−04	2.30	82.25
407656	AW747986	Hs. 37443	Homo sapiens mRNA; cDNA DKFZp434B2119 (f	3.664E−04	2.29	45
452852	AK001972	Hs. 30822	hypothetical protein FLJ11110	4.496E−06	2.29	121.5
456563	AA989220	Hs. 766	ESTs	1.715E−02	2.29	75
449103	T24968	Hs. 23038	HSPC071 protein	9.789E−05	2.29	53.75
425960	AW410646	Hs. 164649	hypothetical protein DKFZp434H247	2.493E−03	2.29	52.75
417386	AL037228	Hs. 82043	Dt23 gene product	2.841E−02	2.28	37.25
443189	AB023179	Hs. 9059	KIAA0962 protein	9.877E−04	2.28	38.5
439815	AA206079	Hs. 6693	hypothetical protein FLJ20420	8.804E−05	2.28	46.5
404298			C6001238*: gi|121715|sp|P26697|GTA3_CHICK	5.420E−03	2.28	42
441664	AW748420	Hs. 6236	Homo sapiens cDNA: FLJ21487 fis, clone C	9.882E−04	2.28	58.5
448959	AI610343	Hs. 186355	ESTs	2.020E−04	2.27	46
417206	AA291183	Hs. 81648	hypothetical protein FLJ11021 similar to	1.184E−03	2.27	40.75
422460	AW445014	Hs. 197746	ESTs	2.659E−02	2.27	33.5
448410	AK000227	Hs. 21126	hypothetical protein FLJ20220	6.881E−02	2.27	32.75
424528	AW073971	Hs. 238954	ESTs, Weakly similar to KIAA1204 protein	6.225E−04	2.27	45.25
456721	AA533356		gb: nj67f10.s1 NCI_CGAP_Pr10 Homo sapiens	1.038E−02	2.27	30.25
416269	AA177138	Hs. 161671	ESTs	6.350E−03	2.27	47.75
430308	BE540865	Hs. 238990	cyclin-dependent kinase inhibitor 1B (p2	1.398E−05	2.27	105
446161	AA628206	Hs. 14125	p53 regulated PA26 nuclear protein	4.251E−04	2.27	74.75
414256	AW410035	Hs. 75862	MAD (mothers against decapentaplegic, Dr	1.968E−02	2.27	37.5
457819	AA057484	Hs. 35406	ESTs, Highly similar to unnamed protein	2.574E−02	2.27	30.5
420463	D51872	Hs. 23492	ESTs	4.267E−03	2.27	33
408077	AL133574	Hs. 42458	Homo sapiens mRNA; cDNA DKFZp586C1817 (f	5.869E−03	2.27	75
401403			Target Exon	3.235E−02	2.26	59.75
440675	AW005054	Hs. 47883	ESTs, Weakly similar to KCC1_HUMAN CALCI	5.063E−06	2.26	163
417867	AW952547	Hs. 194603	ESTs, Moderately similar to I38022 hypot	7.964E−03	2.26	39.25
448356	AL120837	Hs. 20993	high-glucose-regulated protein 8	3.340E−02	2.25	32
421931	NM_000814	Hs. 1440	gamma-aminobutyric acid (GABA) A recepto	2.471E−04	2.25	74.25
435524	AK000001	Hs. 4914	Homo sapiens mRNA for FLJ00031 protein,	4.354E−05	2.25	49.5
439475	AA836331	Hs. 134981	ESTs	4.626E−03	2.25	41
414436	U50078	Hs. 76127	hect (homologous to the E6-AP (UBE3A) ca	9.997E−03	2.25	62.25
436856	AI469355	Hs. 127310	ESTs	8.090E−07	2.25	210.5
407151	H25836	Hs. 301527	ESTs, Moderately similar to unknown [H.s	2.111E−07	2.25	231.25
435756	AI418466	Hs. 33665	ESTs	3.491E−04	2.25	56.25
416754	H07145	Hs. 6799	ESTs, Weakly similar to T12483 hypotheti	1.690E−03	2.25	46.75
444647	H14718	Hs. 11506	Human clone 23589 mRNA sequence	2.255E−02	2.25	45
440638	AI376551		gb: te64e10.x1 Soares_NFL_T_GBC_S1 Homo s	3.480E−03	2.25	36.25
429025	AI399910	Hs. 266782	KIAA1826 protein	3.338E−03	2.25	35.25
418383	AA218986	Hs. 118854	ESTs	3.769E−03	2.25	32.25
438829	AA826926	Hs. 204214	ESTs, Weakly similar to I38022 hypotheti	2.600E−03	2.25	42.75
416240	NM_001981	Hs. 79095	epidermal growth factor receptor pathway	2.219E−05	2.25	69.75
438030	X98427	Hs. 122634	ESTs	1.243E−03	2.24	213.75
419200	AW966405	Hs. 288856	prefoldin 5	3.897E−07	2.24	136.25
433713	AW976511	Hs. 112592	ESTs	8.288E−03	2.24	91
447109	X69086	Hs. 286161	Homo sapiens cDNA FLJ13613 fis. clone PL	3.777E−03	2.24	52
452870	AW502761	Hs. 30909	KIAA0430 gene product	1.246E−02	2.24	31.25
427268	X78520	Hs. 174139	chloride channel 3	1.922E−04	2.24	87.25
439046	AA947354		gb: od86e11.s1 NCI_CGAP_Ov2 Homo sapiens	1.488E−04	2.24	39.25
453929	AW190054		gb: xl11d05.x1 NCI_CGAP_Ut4 Homo sapiens	1.657E−02	2.23	30.25
417944	AU077196	Hs. 82985	collagen, type V, alpha 2	3.331E−04	2.23	129.75
417303	NM_001698	Hs. 81886	AU RNA-binding protein/enoyl-Coenzyme A	3.330E−04	2.23	67
411495	AP000693	Hs. 70359	KIAA0136 protein	2.411E−02	2.23	36.25
452144	AA032197	Hs. 102558	Homo sapiens, clone MGC: 5352, mRNA, comp	2.789E−05	2.22	58.25
405270			NM_018850*: Homo sapiens ATP-binding cass	1.389E−02	2.22	58
452436	BE077546	Hs. 31447	ESTs, Moderately similar to A46010 X-lin	2.491E−03	2.22	40.25
450314	AA574309	Hs. 283402	TCR eta	2.286E−03	2.22	38
442806	AW294522	Hs. 149991	ESTs	3.790E−02	2.22	34.75
406274			Target Exon	1.084E−03	2.22	69.5
449437	AI702038	Hs. 100057	Homo sapiens cDNA: FLJ22902 fis, clone K	1.922E−04	2.22	73.75
434260	AF121856	Hs. 284291	sorting nexin 6	1.321E−05	2.22	100.5
445893	AI610702	Hs. 28212	ESTs, Weakly similar to TRHY_HUMAN TRICH	2.942E−05	2.22	63.75
429520	AA160142	Hs. 205058	hypothetical protein FLJ20075	1.839E−02	2.22	39
437801	AA613866	Hs. 5848	Homo sapiens mRNA; cDNA DKFZp564L222 (fr	4.426E−02	2.22	39
425508	AA991551	Hs. 97013	Homo sapiens, Similar to RIKEN cDNA 2310	3.290E−05	2.21	59.25
425303	AA354785		gb: EST63098 Jurkat T-cells V Homo sapien	5.450E−02	2.21	30.75
450157	AW961576	Hs. 60178	ESTs	3.074E−03	2.20	69
453927	AA082465	Hs. 125031	choline/ethanolaminephosphotransferase	9.265E−06	2.20	58
437580	AA761075	Hs. 293567	ESTs	4.094E−03	2.20	54.75
408990	AL022395	Hs. 49526	f-box and leucine-rich repeat protein 4	2.289E−03	2.20	44
438619	AB032773	Hs. 6341	TU12B1-TY protein	1.076E−02	2.20	39
404149			C6002509*: gi|5031885|ref|NP_005568.1|li	5.296E−02	2.20	36.25
448102	AI750793	Hs. 20295	CHK1 (checkpoint, S. pombe) homolog	1.901E−02	2.20	30
433618	AA602539	Hs. 345494	ESTs	4.698E−02	2.20	30.25
446591	H44186	Hs. 15456	PDZ domain containing 1	5.821E−07	2.20	113.5
416041	AA345547	Hs. 53263	hypothetical protein FLJ13287	5.649E−03	2.20	57.75
414588	AA302905		gb: EST10607 Adipose tissue, white I Homo	4.681E−04	2.20	38.25
459680	H96982	Hs. 42321	ESTs	3.860E−04	2.20	84.25
452574	AF127481	Hs. 301946	lymphoid blast crisis oncogene	1.483E−03	2.19	49
412240	H72176	Hs. 4273	hypothetical protein FLJ13159	2.713E−03	2.19	33.25
423996	AF205071	Hs. 137425	solute carrier family 21 (organic anion	8.139E−02	2.19	50.75
440113	AI916532	Hs. 188272	ESTs	1.078E−03	2.19	49.5
456073	AA587775	Hs. 66295	multi-PDZ-domain-containing protein	1.316E−05	2.19	56
419675	AL079310	Hs. 92260	high-mobility group protein 2-like 1	1.182E−03	2.18	50.25
427631	AB029023	Hs. 179946	KIAA1100 protein	5.139E−05	2.18	73
442332	AI693251	Hs. 8248	Target CAT	1.650E−04	2.18	91.5
450969	BE244603	Hs. 25726	transposon-derived Buster 1 transposase-l	2.101E−03	2.18	45
421077	AK000061	Hs. 101590	hypothetical protein	6.854E−03	2.17	46.5
444291	AI598022	Hs. 193989	TAR DNA binding protein	2.232E−04	2.17	40
407904	W44735	Hs. 9286	Homo sapiens cDNA: FLJ21278 fis, clone C	1.647E−04	2.17	35.5
442129	N36918	Hs. 20142	PNAS-127 protein	2.948E−03	2.17	34
412025	AI827451	Hs. 24143	Wiskott-Aldrich syndrome protein interac	3.489E−05	2.17	82.75
412059	AA317962	Hs. 249721	ESTs, Moderately similar to PC4259 ferri	3.674E−02	2.17	42
432235	AA531129	Hs. 190297	ESTs	5.460E−02	2.17	36.75
424247	X14008	Hs. 234734	lysozyme (renal amyloidosis)	8.638E−04	2.17	158.25
413326	H88621	Hs. 19762	ESTs, Weakly similar to KIAA1140 protein	7.992E−03	2.17	45.75
416065	BE267931	Hs. 78996	proliferating cell nuclear antigen	2.240E−04	2.17	123.25
413012	D83777	Hs. 75137	KIAA0193 gene product	2.948E−03	2.16	53.75
442092	AW578669		hypothetical protein FLJ12439	1.619E−03	2.16	31.25
423630	AB011132	Hs. 129952	KIAA0560 gene product	3.203E−03	2.16	40.75
421921	H83363	Hs. 6820	translocase of inner mitochondrial membr	4.039E−04	2.15	52.25
429586	T73510	Hs. 209153	angiopoietin-like 3	4.604E−05	2.15	132
449217	AA278536	Hs. 23262	ribonuclease, RNase A family, k6	7.916E−02	2.15	45.5
409518	BE384836	Hs. 3454	KIAA1821 protein	8.314E−05	2.15	34.25
414525	C14904	Hs. 45184	Homo sapiens cDNA FLJ12284 fis, clone MA	4.233E−04	2.15	44
411979	X85134	Hs. 72984	retinoblastoma-binding protein 5	9.468E−04	2.15	42.75
448705	H05072	Hs. 124984	ESTs, Moderately similar to ALU7_HUMAN A	2.180E−02	2.15	37.25
419165	AW860767	Hs. 118879	ESTs	1.038E−02	2.15	36
419479	AI288348	Hs. 23450	mitochondrial ribosomal protein S25	8.590E−02	2.15	35.5
432709	H17238		gb: ym42f03.r1 Soares infant brain 1NIB H	1.353E−03	2.15	33.5
440266	AA088809	Hs. 19525	hypothetical protein FLJ22794	9.808E−05	2.15	82.5
440010	AA534930	Hs. 127236	hypothetical protein FLJ12879	1.619E−03	2.15	46.25
408866	AW292096	Hs. 255036	ESTs	4.439E−03	2.14	43.5
438023	AF204883	Hs. 6048	FEM-1 (C. elegans) homolog b	3.849E−04	2.14	50
439318	AW837046	Hs. 6527	G protein-coupled receptor 56	3.331E−04	2.14	68.75
403576			C3000124: gi|12737057|ref|XP_012129.1|si	5.416E−03	2.14	35
429567	R35606	Hs. 326800	Human EST clone 53125 mariner transposon	3.623E−03	2.13	32
452679	Z42387	Hs. 83883	transmembrane, prostate androgen induced	3.069E−03	2.13	32
424904	AI221739	Hs. 96899	ESTs	1.035E−02	2.13	38.75
441991	AW844404	Hs. 126901	Homo sapiens mRNA full length insert cDN	3.860E−04	2.13	45.25
433160	AW207002	Hs. 134342	TASP for testis-specific adriamycin sens	1.543E−02	2.13	58.25
409969	AW514668	Hs. 194258	ESTs, Moderately similar to ALU5_HUMAN A	2.333E−02	2.13	34.75
437796	AW407459	Hs. 5836	mitochondrial ribosomal protein S23	2.218E−05	2.13	57
404240			NM_018950: Homo sapiens major histocompat	6.450E−06	2.13	177.25
413587	AA156164	Hs. 286241	protein kinase, cAMP-dependent, regulato	1.842E−03	2.13	53.5
453022	AA031499	Hs. 118489	ESTs	1.483E−03	2.13	76
407183	AA358015		gb: EST66864 Fetal lung III Homo sapiens	5.708E−05	2.13	49.25
408047	AW205461	Hs. 243612	ESTs	6.105E−03	2.13	40.5
445800	AA126419	Hs. 32944	inositol polyphosphate-4-phosphatase, ty	9.289E−03	2.13	40
401952			Target Exon	3.784E−02	2.13	31.5
407874	AI766311	Hs. 289047	Homo sapiens cDNA FLJ14059 fis, clone HE	1.361E−06	2.12	156.25
430399	AI916284	Hs. 199671	ESTs	4.676E−04	2.12	62.25
444913	AI362726	Hs. 193656	Homo sapiens mRNA for KIAA1658 protein,	2.218E−05	2.12	42.5
412760	AW379030	Hs. 41324	ESTs	4.117E−05	2.11	55.75
443804	AL135352	Hs. 255883	ESTs, Weakly similar to I38022 hypotheti	9.035E−04	2.11	44
454146	BE086548	Hs. 42346	calcineurin-binding protein calsarcin-1	1.848E−03	2.11	115
425745	U44060	Hs. 14427	Homo sapiens cDNA: FLJ21800 fis, clone H	6.541E−04	2.11	81
426676	R19549	Hs. 13996	Homo sapiens cDNA: FLJ23260 fis, clone C	1.640E−06	2.11	147.75
430587	AK000341	Hs. 246107	elongation of very long chain fatty acid	1.344E−04	2.11	91.5
448442	AB033281	Hs. 21229	f-box and WD-40 domain protein 1B	6.107E−03	2.11	52
429286	AA449239	Hs. 154855	ESTs	4.644E−04	2.11	35
439656	AW138241	Hs. 210846	ESTs	8.798E−05	2.11	45.25
438135	AI253025	Hs. 190426	ESTs	1.085E−03	2.11	99
407795	AA044754	Hs. 48821	ESTs	3.678E−04	2.11	58.5
447749	T53260	Hs. 191091	ESTs	7.069E−05	2.11	51.25
426685	R20212	Hs. 28454	ESTs	3.077E−03	2.10	40.25
440495	AA887212	Hs. 14161	hypothetical protein DKFZp434I1930	5.008E−03	2.10	32.5
456373	BE247706	Hs. 89751	membrane-spanning 4-domains, subfamily A	2.022E−04	2.10	61.75
445817	NM_003642	Hs. 13340	histone acetyltransferase 1	9.044E−04	2.10	52.75
449901	AI674072		gb: wd15h01.x1 Soares_NFL_T_GBC_S1 Homo s	5.149E−04	2.10	41.5
439161	Y15164	Hs. 6483	oral-facial-digital syndrome 1	6.522E−04	2.10	38.75
442229	AI885776	Hs. 8164	Mulibrey nanism	7.120E−03	2.10	37.5
441024	AW081530	Hs. 268231	ESTs	2.934E−03	2.10	31.5
417691	AU076610	Hs. 82399	low density lipoprotein receptor defect	6.847E−03	2.10	30
445447	H14522	Hs. 8358	ribosomal protein S4, X-linked	2.286E−03	2.10	50
423703	NM_014913	Hs. 131915	KIAA0863 protein	1.086E−04	2.10	54
448749	AW859679	Hs. 21902	Homo sapiens clone 25237 mRNA sequence	2.491E−02	2.09	38
426272	AW450671	Hs. 189284	ESTs	2.953E−05	2.09	94
450124	N95443	Hs. 19180	Homo sapiens mRNA; cDNA DKFZp564E122 (fr	2.013E−03	2.09	47
413856	D13639	Hs. 75586	cyclin D2	2.602E−03	2.09	45.75
446103	U90918	Hs. 13804	hypothetical protein dJ462O23.2	1.900E−02	2.09	31
453173	AB007902	Hs. 32168	KIAA0442 protein	3.965E−06	2.09	169.25
450903	AA011670	Hs. 114749	ESTs	3.668E−04	2.09	40.75
421766	AA481157	Hs. 108110	DKFZP547E2110 protein	1.620E−03	2.08	43.25
409259	AW608930	Hs. 52184	hypothetical protein FLJ20618	7.498E−07	2.08	83.5
438154	AI671957	Hs. 19523	Homo sapiens clone 022f05 My030 protein	1.646E−06	2.08	84.5
437469	AW753112	Hs. 15514	hypothetical protein MGC3260	2.387E−03	2.08	55
451334	AI122691	Hs. 13268	ESTs	2.732E−04	2.08	49.25
418459	R85436	Hs. 268814	ESTs	2.866E−04	2.07	61.25
424737	BE301883	Hs. 152707	glioblastoma amplified sequence	1.146E−04	2.07	50.75
454038	X06374	Hs. 37040	platelet-derived growth factor alpha pol	2.713E−03	2.07	41.75
408951	AW407227	Hs. 49282	hypothetical protein FLJ11088	3.336E−02	2.07	32.75
431923	AI741770	Hs. 292690	ESTs, Weakly similar to I38022 hypotheti	2.599E−03	2.07	43.5
447560	AF065214	Hs. 18858	phospholipase A2, group IVC (cytosolic,	4.846E−02	2.07	40.25
413836	W92003	Hs. 70614	ESTs	2.751E−02	2.07	30
450331	AA009536	Hs. 38323	ESTs	8.945E−03	2.07	34.75
446229	AI744964	Hs. 14449	KIAA1609 protein	9.450E−04	2.07	38.75
440706	AA927562	Hs. 148234	ESTs	2.101E−03	2.07	38.75
441872	BE567100	Hs. 154938	hypothetical protein MDS025	6.092E−06	2.07	121.75
415710	J04543	Hs. 78637	annexin A7	1.245E−02	2.07	31.75
428220	BE183533	Hs. 347128	Human DNA sequence from clone 34B21 on c	2.733E−06	2.07	76.5
438363	AI886351	Hs. 22353	hypothetical protein FLJ21952	2.129E−04	2.07	65.25
414781	D50917	Hs. 77293	KIAA0127 gene product	2.237E−04	2.06	41
421297	AB037360		KIAA1255 protein	2.940E−05	2.06	74.5
452068	W76412	Hs. 57877	ESTs	9.454E−04	2.06	59
429788	U87791	Hs. 221040	HBS1 (S. cerevisiae)-like	6.130E−02	2.05	38.5
414718	H95348	Hs. 107987	ESTs	3.234E−02	2.05	53
421727	Y13153	Hs. 107318	kynurenine 3-monooxygenase (kynurenine 3	1.389E−02	2.05	102.25
432401	NM_013330	Hs. 274479	NME7	2.193E−03	2.05	104.5
448920	AW408009	Hs. 22580	alkylglycerone phosphate synthase	2.599E−03	2.05	53.25
433735	AA608955	Hs. 109653	ESTs	3.337E−03	2.05	41.25
415083	AI632683	Hs. 27179	Homo sapiens cDNA FLJ12933 fis, clone NT	2.842E−02	2.05	38.25
453078	AF053551	Hs. 31584	metaxin 2	3.467E−03	2.05	37.5
453574	AI767947	Hs. 50841	ESTs	1.246E−02	2.05	34.25
426124	AI268389	Hs. 250697	phosphatidylinositol glycan, class F	4.291E−02	2.05	31.5
451408	AI795947	Hs. 209596	ESTs	1.438E−02	2.05	30
414553	AI813865	Hs. 164478	hypothetical protein FLJ21939 similar to	2.038E−02	2.05	39.25
431192	AI670056	Hs. 137274	ESTs, Weakly similar to SP62_HUMAN SPLIC	7.401E−03	2.04	53.25
457830	BE147896	Hs. 14662	ESTs	7.394E−03	2.04	31.5
449480	AI741617	Hs. 108447	spinocerebellar ataxia 7 (olivopontocere	4.046E−04	2.04	44.25
448384	R12314	Hs. 21056	Homo sapiens cDNA: FLJ21366 fis, clone C	1.085E−03	2.04	57.75
451798	BE297567	Hs. 27047	hypothetical protein FLJ20392	1.480E−03	2.04	32.25
409245	AA361037	Hs. 288036	tRNA isopentenylpyrophosphate transferas	4.991E−02	2.04	39.25
446946	AI878932	Hs. 317	topoisomerase (DNA) I	2.490E−02	2.04	32.75
421166	AA305407	Hs. 102308	potassium inwardly-rectifying channel, s	1.298E−03	2.04	69.25
434275	H92087	Hs. 114288	ESTs, Weakly similar to A47582 B-cell gr	5.672E−04	2.04	127.5
428706	AA432030	Hs. 265827	interferon, alpha-inducible protein (clo	8.647E−07	2.04	242
435841	R28522	Hs. 186937	ESTs	3.666E−04	2.03	44.5
422684	BE561617	Hs. 119192	H2A histone family, member Z	2.714E−03	2.03	53.25
410333	AL049538	Hs. 62349	ras association (RalGDS/AF-6) domain con	1.157E−02	2.03	33.25
446126	AW085909	Hs. 10177	pleckstrin homology domain interacting p	3.205E−03	2.03	62
421628	AL121317	Hs. 106210	hypothetical protein FLJ10813	3.780E−03	2.03	56.75
448939	BE267795	Hs. 22595	hypothetical protein FLJ10637	1.246E−02	2.03	49.25
420747	BE294407	Hs. 99910	phosphofructokinase, platelet	6.596E−03	2.03	50.25
420977	AW794019	Hs. 100651	golgi SNAP receptor complex member 2	4.088E−03	2.03	30.5
432886	BE159028	Hs. 279704	chromatin accessibility complex 1	4.034E−02	2.02	52
432960	AW150945	Hs. 144758	ESTs	8.629E−04	2.02	45.25
429857	AF089897	Hs. 294030	topoisomerase-related function protein 4	4.393E−06	2.02	43.75
407879	AA045464	Hs. 6557	zinc finger protein 161	3.776E−03	2.02	39.75
428708	NM_014897	Hs. 190386	KIAA0924 protein	1.543E−02	2.02	36.75
424670	W61215	Hs. 116651	epithelial V-like antigen 1	1.091E−04	2.02	93
421315	D78791	Hs. 103419	fasciculation and elongation protein zet	6.077E−06	2.02	90.25
437370	AL359567	Hs. 161962	Homo sapiens mRNA; cDNA DKFZp547D023 (fr	3.501E−04	2.02	48.75
445330	R52656	Hs. 21691	ESTs	8.939E−03	2.02	63.75
433882	U90441	Hs. 3622	procollagen-proline, 2-oxoglutarate 4-di	7.522E−04	2.02	57.5
425409	H18021	Hs. 25005	hypothetical protein MGC3329	1.620E−03	2.02	30.75
407807	AL031427	Hs. 40094	Human DNA sequence from clone 167A19 on	6.339E−03	2.01	34
414900	AW452420	Hs. 248678	ESTs	3.481E−03	2.01	57.25
408194	AA601038	Hs. 191797	ESTs, Weakly similar to S65657 alpha-1C-	2.035E−02	2.01	38.75
410582	AW867197	Hs. 337561	hypothetical protein FLJ21616	5.072E−06	2.01	103.5
422576	BE548555	Hs. 118554	CGI-83 protein	6.601E−03	2.01	79.5
418504	BE159718	Hs. 85335	Homo sapiens mRNA; cDNA DKFZp564D1462 (f	3.692E−05	2.01	80
422431	AI769410	Hs. 221461	ESTs	3.471E−03	2.01	34.5
426369	AF134157	Hs. 169487	Kreisler (mouse) maf-related leucine zip	1.765E−05	2.01	123.75
413949	AA316077	Hs. 75639	Human TB1 gene mRNA, 3′ end	2.410E−02	2.01	42.5
451625	R56793	Hs. 106576	alanine-glyoxylate aminotransferase 2-li	2.789E−05	2.00	184.5
405688			NM_018850*: Homo sapiens ATP-binding cass	1.551E−03	2.00	83.25
418838	AW385224	Hs. 35198	ectonucleotide pyrophosphatase/phosphodi	7.726E−06	2.00	64.5
437672	AW748265	Hs. 5741	flavohemoprotein b5?	6.821E−04	2.00	45.75
458389	H70284	Hs. 160152	ESTs, Weakly similar to FPHU alpha-fetop	8.798E−05	2.00	45.25
417727	AL133623	Hs. 82501	similar to mouse Xrn1/Dhm2 protein	6.585E−03	2.00	41
444743	AA045648	Hs. 301957	nudix (nucleoside diphosphate linked moi	1.715E−02	2.00	40.75
429167	BE465867	Hs. 197751	KIAA0666 protein	7.118E−03	2.00	40.25
451141	AW772713	Hs. 247186	ESTs	2.599E−03	2.00	40
430178	AW449612	Hs. 152475	ESTs	1.337E−02	2.00	34.75
421620	AA446183	Hs. 91885	ESTs, Weakly similar to I55214 salivary	4.811E−03	2.00	33.25
439898	AW505514	Hs. 209561	KIAA1715 protein	2.596E−03	2.00	32.5
452874	AK001061	Hs. 30925	hypothetical protein FLJ10199	3.337E−02	2.00	30
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of Hep C+ Liver over Trimean of Hep C− liver Ratio
R3: Difference of Trimean of Hep C+ Liver vs. Trimean of Hep C− Liver

[0343]

TABLE 3B
Pkey	CAT Number	Accession
407992	103172_2	AW418811 AI743200 AI458141
408731	10774_1	R85652 AA114024 AA296219 AA375304 AW963796 AW885952 AW020969 AA114025 AI804930 BE350971 AI765355
		AW317067 AW974763
		H85930 AW172600 AI310231 AW612019 D62908 D62864 AA652738 AI674617 AI494064 AW138666 AI147620
		AI147629 AW611793 AI668922
		AI971005 AI864742 AA174171
410099	117647_1	AA081630 T08671 AI174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714
		N79906 AW901977 AW901980 W52882
		T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237 AA917004 AA716027 AI439658
		AA283724 AI805992 AI457096
		AA084618 BE467736 AI092635 AI887863 AI697593 AA436618 AI167419 AI418634 T31586 AA436630 AA706191
		AI041169 AI422304 T03534
		AA211402 AI204899 AI366472 AW827081 AA788593 T32736 AI767935 AA167791 AA747914 AA663870 AI865504
411590	125064_1	T96183 T64070 AA094134
411656	1252973_1	AW855576 AW855650 AW855578 AW855577 AW855642 AW855619 AW855624 AW855621
411777	1257741_1	BE067552 BE067800 BE067593 BE067714 BE067819 H49900
413007	1343540_1	BE046662 BE046697 BE046655
413509	1374313_1	BE145419 BE145433
413645	138145_1	AA130992 AA503835 AW969537
414279	143227_1	AW021691 AI537404 R45431 AI333439 AI741845 AI674468 R44190 R52535 R52617 AI220925 AI979148 AI744688
		AW242437 AA618148
		AI983837 AA399623 AI676204 AI420077 N24944 D51042 AA282786 AA137264 AW236107 AW769997 N53529
		AI624731 AI968243 AI863637
		Z41183 N38931 H99461 AI129279 AI767302 AI474904 H72893 AI434776 AI498342 AI089287 AA398984 H79114
		N33821 AA625451 AA282874
		AA137263 H72493 AF236691 AA482849 R23405 R25093 R53271 BE073129 R52586 BE073137 Z33587 AW080738
		Z45484 AW889665
414496	145392_1	W73853 AA928112 W77887 AW889237 AA148524 AI749182 AI754442 AI338392 AI253102 AI079403 AI370541
		AI697341 H97538 AW188021
		AI927669 W72716 AI051402 AI188071 AI335900 N21488 AW770478 W92522 AI691028 AI913512 AI144448 W73819
		AA604358 N28900 W95221
		AI868132 H98465 AA148793
414588	146467_1	AA302905 AA495793 AA149783
416475	1596398_1	T70298 H58072 R02750
416611	160379_1	AA568308 AI453629 AI984473 AI341559 AI983169 AA181902 AI708321 AI695791 AI695792 AI478300
418259	173388_1	AA215404 AI990909 BE464132 AW271459 N74332 AI262061
418304	173658_2	AA215702 AA368006 AA215703 BE066555 BE006876
418876	179960_1	AA740616 AA654854 AA229923
420825	196769_1	AI656727 AI697887 AI802122 AA910877 Z28718 T16711 AA651731 AL047264 BE000621 R68736 AW992695
		AI768764 AW271284 AW974653
		AI308951 AW055146 R93609 AW467031 AI096866 AI371871 AI126182 AI564756 AI361460 AI358914 AI419231
		AW439733 R87059 AA628064
		AW088970 AW008695 R68682 AI719136 R97752 AW196262
420985	19829_1	X94703 NM_004249 R52316 T87420 N46403 Z36855 BE076834
421057	198849_1	T58283 AA765038 AA283052 H99396 AA814751 AI032674 N81016 N81017 BE222349 AA830545
421272	200810_1	AA704157 AA286825 C15898 C15173 D81736 AI810506 BE466071 H84948 R88291 H85515 AW014470
421297	200_1	AB037360 NM_016376 AB033081 T25038 R94364 AA399607 AW814619 BE172335 AW609548 T83895 N40773
		T86064 N40777 N40757
		BE550945 AW450283 H62663 AI298087 AI288098 N55959 T83725 H65293 N30050 AW858563 AW858561
		AW858575 AW861931 AW858569
		AW363633 N30072 AW858524 AW754343 AW754342 AW604731 AW754345 AI363734 N30068 BE155949 T16974
		R60281 BE071291 AI423079
		BE071350 AI917153 AA256914 AA436381 AW383355 AI630341 AW383736 AW388181 BE002858
		AW815513 AA351367
421718	20595_1	AL117574 AI681945 BE503055 AW015330 C16652 AA441855 AA329853
		AW962502 AA441830 AF114049
423886	232905_1	AA332098 AW950499 AW950497
423983	233891_1	AA333261 AA333365 AA552870
425303	249780_1	AA354785 AA354792 AW958427
425757	255956_1	AA363171 AW963347 AA371863
427213	276052_1	AW007211 AA399252 AA960991 BE467259
427384	278072_1	T82854 AA401778 R92652
428342	290035_2	AI739168 AA426249 AI199636 AW505198 AW977291 AA824583 AA883419 AA724079 AI015524 AI377728 AW293682
		AI928140 AA731438
		AI092404 AI085630 AA731340
429978	31150_1	AA249027 AL038984 AK001993 AL080066 AV652725 BE566226 AA345557 AA315222 AA090585 AA375688
		AA301092 AA298454 W05762
		AW607939 H51658 D83880 N84323 BE296821 AW947007 D61461 AW079261 AA329482 AW901780 AI354442
		AA772275 R31663 AI354441
		AI767525 H92431 AI916735 H93575 AI394255 AW014741 AI573090 C06195 AW612857 AW265195 AI339558
		AI377532 AI308821 AI919424
		AI589705 AW055215 AI336532 AI338051 AA806547 C75509 C00618 AW071172 AW769904 AA630381 AI678018
		AI863985 D79662 BE221049
		AW265018 AI589700 AW196655 N76573 AI370908 BE042393 N75017 AI698870 AW960115
430068	312849_1	AA464964 M85405 AA947566
432474	348197_1	AA584042 AW973273 AA548798
432600	350959_1	AI821085 AW973464 AA554802 AI821831 AA657438 AA640756 AA650339
432676	352582_2	AI187366 AA558869 AA618478
432689	35275_1	AB018320 H56457 AA247916 N83488 N87920 AA095653 T19858 AL134279 AA094167 AI673378 AI000340
		R47500 W16595 AW152297 AI625937
		AA002027 AI814851 AA902666 AI039729 AW975053 BE302243 AI240793 AA193203 N55818 AI886651
		AA877735 AA565288 AI284399
		AA707069 AA775885 AI014967 AA524249 R56212 AA878627 H80252 AA085731 AA657859 AI753853 AA564328
		H83107 H56458 AA193204
		AI075230 AA001823 AI269462 F09349 N87900 AA653028 T71600 T71751 T71812 R58128 AI890218 AL134289
		T71659 AA323827 N92477
		T54867 AA985252 F11689 R56295 BE086764 N88917 AA013161 BE407758 AW993041 BE018672 AL120628
		H54590 AW364176
432709	353139_1	H17238 AA563739 F05559 F06116
433464	367082_1	N92481 AI475594 AW674508 AA593748 AW974058
433847	374914_1	AA610266 AA610273 AA632625 AA812563 AI688018 AI094802 H79160 R99139
433891	376239_1	AA613792 AW182329 T05304 AW858385
434280	382816_1	BE005398 AA628622 AA994155
437151	433855_1	AA745618 AA745616 AW805449 BE159081
438141	450685_1	AW946871 AW946782 AW946955 AA778849
438980	467544_1	AW502384 AI982587 AA828822
439046	468133_1	AA947354 AA829660 AI687296
439195	46967_1	H89360 AF086037 H89546
440638	499025_1	AI376551 T87714 AA897445
442048	531432_1	AA974603 AI984319 AW340495
442092	532588_1	AW578669 AI862106 AW025563 AW193658 AA976004
444314	600667_1	AI140497 AW749625 AW749626 AW749644
448219	75529_4	AA228092 AW577775 AI033234 BE076308 AI377195 AW577769
449001	792914_1	AI619957 AI654836 R99473 H51659 R99472
449901	818599_1	AI674072 BE268487
451107	85931_1	AA235108 W00590 H30674 T12414 AA384068 AA482520 AA325367 AW955325 AW517234 AI749193
		AW500012 AW503974 AI720354 AI769223
		AW058126 AI371974 AW021415 AA017421 AI027749 R55450 W80453 AA601599 N63625 AA235217
		AA015723 AI492264 AI075880 AW444749
		AI056860 AI684298 AI826258 AA055649 AA558483 AAI59479 AA533567 AA496743 AA417823 AA069759
		AA057021 BE247112 N68913
		AA486633 AA486538 N93443 T12413
452480	919099_1	AI903526 AI903572 AI903574 AI903571
453929	98823_1	AW190054 AI263834 AA040074
456034	142696_1	AW450979 AA136653 AA136656 AW419381 AA984358 AA492073 BE168945 AA809054 AW238038
		BE011212 BE011359 BE011367 BE011368
		BE011362 BE011215 BE011365 BE011363
456721	222858_1	AA533356 AW468427 R67736 AA779031 AA614088 AI823404 AA318991 AA720986
457247	308656_1	AA458605 AW977252 AI261627 AW274550 AI418272 AW665579 AA731376 AW293861 D80453 AI217860
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0344]

TABLE 3C
Pkey	Ref	Strand	Nt_position
400517	9796686	Minus	49996-50346
401016	8117441	Plus	126234-126359, 128050-128236
401091	9958240	Plus	94760-94898
401197	9719705	Plus	176341-176452
401403	7710966	Plus	146180-146294
401898	8570008	Minus	72013-72132, 72400-72487
401928	3873182	Plus	54932-55070
401952	3319121	Minus	53770-53979
402041	7770639	Plus	69353-69454
402439	9796503	Minus	108604-108764
402507	9797889	Plus	118979-119086
402727	9211324	Plus	54596-54777
402737	9212184	Minus	13358-13552
402847	9408716	Minus	104107-104314
402964	9581599	Minus	46624-46784
403027	7670575	Plus	60696-60932, 61362-61521
403330	8516153	Plus	116558-116698
403575	8101156	Minus	81961-82068
403576	6862645	Minus	73475-73940, 74079-74207
403707	7108128	Minus	132794-133294
403738	7212067	Plus	38434-38562, 56876-57007,
			59789-59876, 60714-60933,
			62986-63265
403743	7652003	Minus	136463-136646
403790	8084957	Minus	87826-87947, 89835-90002
403809	8568861	Plus	33910-34129, 34583-34862
403976	7657840	Plus	24755-24969
404149	7534008	Plus	121831-121951, 124044-124150
404240	5002624	Minus	116132-116407, 116653-116922
404298	9944263	Minus	73591-73723
404676	9797204	Minus	56167-56342, 58066-58189,
			58891-59048, 60452-60628
405102	8076881	Minus	120922-121296
405141	8980911	Plus	99861-100054
405268	4156151	Minus	24404-24521
405270	4156145	Minus	3952-4123, 6886-7010, 8541-8728
405688	4508117	Minus	88702-88899
405689	4508117	Minus	92558-92698, 94282-94382,
			97977-98180, 99202-99285
406038	8389537	Plus	37764-37877
406274	7543787	Plus	932-1123
406423	9256411	Plus	165600-165824
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0345] Table 4A lists about 200 genes down-regulated in Hepatitis C positive liver tissues compared to Hepatitis C negative liver tissues. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of Hepatitis C negative liver tissues to the “weighted average” of Hepatitis C positive liver tissues was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the Hepatitis C negative liver tissues was set to the trimean of various different Hepatitis C negative liver tissues. The “weighted average” of the Hepatitis C positive liver tissues was set to the either 10 or the trimean of various different Hepatitis C positive liver tissues, whichever value was greater to eliminate ratios with a denominator of zero or less. Tables 4B and 4C relate to Table 4A as 3B and 3C relate to 3A.

TABLE 4A
ABOUT 200 GENES DOWN-REGULATED IN HEPATITIS C POSITIVE LIVER TISSUES COMPARED TO
HEPATITIS C NEGATIVE LIVER TISSUES
Pkey	ExAccn	UnigeneID	Unigene Title	R1	R2	R3
450912	AW939251	Hs. 25647	v-fos FBJ murine osteosarcoma viral onco	2.125E−06	21.50	645.75
451831	NM_001674	Hs. 460	activating transcription factor 3	1.410E−04	19.50	189.75
414559	AV656184	Hs. 76452	C-reactive protein, pentraxin-related	1.209E−04	19.31	425.75
447078	AW885727	Hs. 9914	ESTs	2.578E−02	14.00	138
405278			NM_002864: Homo sapiens pregnancy-zone pr	1.132E−03	11.92	115.5
451029	AA852097	Hs. 25829	ras-related protein	7.883E−04	11.12	346.75
416188	BE157260	Hs. 79070	v-myc avian myelocytomatosis viral oncog	7.173E−04	9.65	103.5
442941	AU076728	Hs. 8867	cysteine-rich, angiogenic inducer, 61	1.830E−04	8.74	309.5
434078	AW880709	Hs. 283683	chromosome 8 open reading frame 4	1.545E−02	8.47	76.75
414220	BE298094	Hs. 323806	gb: 601118231F1 NIH_MGC_17 Homo sapiens c	3.560E−02	6.63	57.25
448607	AL042506	Hs. 21599	Kruppel-like factor 7 (ubiquitous)	2.189E−03	6.50	57.5
446066	AI343931	Hs. 149383	ESTs	3.476E−03	6.42	54.75
404501	AW247252		nucleoside phosphorylase	2.939E−02	5.93	53
420101	AW500529	Hs. 95180	KIAA0767 protein	1.621E−03	5.84	61.75
407173	T64349		gb: yc10d08.s1 Stratagene lung (937210) H	1.543E−02	5.80	55
420548	AA278246	Hs. 920	ESTs	5.637E−03	5.46	45.75
414327	BE408145	Hs. 185254	ESTs, Weakly similar to T24435 hypotheti	5.401E−04	5.45	63.5
416434	AW163045	Hs. 79334	nuclear factor, interleukin 3 regulated	1.900E−02	5.45	101.75
427509	M62505	Hs. 2161	complement component 5 receptor 1 (C5a I	1.439E−02	5.43	89.75
419299	AI311085	Hs. 62406	hypothetical protein FLJ22573	3.630E−03	5.05	45.25
400425	AY004252	Hs. 287385	PR domain containing 12	1.922E−04	4.88	39.75
417752	C15737	Hs. 269386	ESTs	4.093E−03	4.80	43
430070	AF197927	Hs. 231967	ALL1 fused gene from 5q31	4.351E−05	4.80	51.25
401149			Target Exon	1.567E−04	4.75	45.75
409233	AK002001	Hs. 51305	v-maf musculoaponeurotic fibrosarcoma (a	2.734E−04	4.74	80.5
423053	BE312679		gb: 601148138F1 NIH_MGC_19 Homo sapiens c	1.242E−03	4.72	64.25
453196	AW003567	Hs. 345309	ESTs	2.602E−03	4.65	41.75
408278	AW876813	Hs. 3343	phosphoglycerate dehydrogenase	2.866E−04	4.52	35.5
401677	H18444		BAI1-associated protein 3	2.177E−02	4.40	34.5
428106	BE620016	Hs. 182470	PTD010 protein	8.236E−04	4.38	57.25
427557	NM_002659	Hs. 179657	plasminogen activator, urokinase recepto	8.798E−05	4.34	71
418303	AA215701	Hs. 186541	ESTs, Weakly similar to I38022 hypotheti	2.749E−02	4.32	44.75
431319	AA873350	Hs. 302232	ESTs	5.146E−02	4.20	81.75
449986	AW864502		gb: PM4-SN0016-120400-004-b12 SN0016 Homo	7.698E−02	4.17	33.75
458867	AW995393		gb: QV0-BN0042-170300-163-g12 BN0042 Homo	5.074E−07	4.16	126.25
423720	AL044191	Hs. 23388	hypothetical protein DKFZp434F0318	5.213E−03	4.15	82.25
433071	BE150229	Hs. 281564	retinal outer segment membrane protein 1	1.922E−03	4.15	32.25
450335	BE218355	Hs. 201781	ESTs, Weakly similar to B34087 hypotheti	1.000E−02	4.13	33.75
448871	BE616709	Hs. 159265	kruppel-related zinc finger protein hcKr	5.425E−03	4.10	47.25
409795	AI934808	Hs. 219132	ESTs, Weakly similar to T46338 hypotheti	3.624E−03	4.02	38.5
401913			ENSP00000249158*: CDNA	3.560E−02	4.00	33
403796			Target Exon	1.239E−03	3.97	44.25
436068	AK000038	Hs. 300979	ESTs, Weakly similar to I38022 hypotheti	1.038E−02	3.95	31.25
449236	AJ403126	Hs. 26373	Homo sapiens cDNA: FLJ23449 fis, clone H	2.255E−02	3.90	35.5
431394	AK000692	Hs. 252351	HERV-H LTR-associating 2	3.334E−03	3.88	35.25
454985	AW849292		gb: IL3-CT0215-020300-090-E06 CT0215 Homo	2.711E−03	3.88	42
444531	BE158822	Hs. 282469	ESTs, Weakly similar to I38022 hypotheti	4.629E−03	3.85	30.5
441063	AA913819	Hs. 188025	ESTs	9.074E−02	3.77	33.5
431861	AA521072	Hs. 292128	ESTs	3.666E−04	3.76	31.75
402517			Target Exon	1.902E−02	3.76	33.75
454598	AW809716		gb: MR4-ST0124-241199-026-h09 ST0124 Homo	7.123E−03	3.75	36
415477	NM_002228	Hs. 78465	v-jun avian sarcoma virus 17 oncogene ho	3.862E−04	3.75	135.25
411349	AW838313		gb: QV2-LT0051-030500-188-f06 LT0051 Homo	7.860E−04	3.70	35
410267	AW978005	Hs. 12600	N-ethylmaleimide-sensitive factor attach	2.814E−03	3.65	32.25
454292	N57559	Hs. 82273	hypothetical protein	7.123E−03	3.65	53
404958			Target Exon	2.491E−03	3.63	37.25
403794			Target Exon	1.763E−03	3.61	45
412176	AW898334		gb: RC3-NN0070-270400-011-f02 NN0070 Homo	7.511E−04	3.60	30
445402	AI222415	Hs. 147852	ESTs	6.522E−04	3.60	34.5
439760	AL355741	Hs. 21641	Homo sapiens mRNA full length insert cDN	7.856E−04	3.55	37.5
450875	AK000724	Hs. 301553	karyopherin alpha 6 (importin alpha 7)	2.938E−05	3.52	83.25
417551	AI816291	Hs. 82273	hypothetical protein	8.224E−04	3.52	103.25
429258	AA448765		gb: zx10e09.r1 Soares_total_fetus_Nb2HF8—	5.001E−03	3.51	33.25
403324			C2000428*: gi|7705383|ref|NP_057536.1|GC	2.038E−02	3.50	30
411929	AA098880	Hs. 69297	ESTs	9.630E−03	3.50	50
418525	AW450369	Hs. 86937	ESTs	1.199E−02	3.47	32.5
403579			Target Exon	1.158E−02	3.47	38.25
449335	AW150717	Hs. 345728	STAT induced STAT inhibitor 3	4.096E−03	3.47	221.25
414428	BE296906	Hs. 182625	VAMP (vesicle-associated membrane protei	5.786E−02	3.45	43.5
449785	AI225235	Hs. 288300	hypothetical protein FLJ23231	2.255E−02	3.45	35.25
430389	AL117429	Hs. 240845	DKFZP434D146 protein	1.489E−02	3.42	31.5
454636	AW811502		gb: QV2-ST0145-061299-015-b04 ST0145 Homo	2.830E−03	3.42	38.75
402889			ENSP00000217123*: FLJ00118 protein (Fragm	2.011E−03	3.42	36.25
405600			C12001673: gi|9631264|ref|NP_048045.1|or	4.808E−03	3.39	36.5
408120	AW299900	Hs. 267632	TATA element modulatory factor 1	5.865E−03	3.38	37.75
446052	AA358760		gb: EST67699 Fetal lung II Homo sapiens c	3.886E−05	3.36	72
409840	AW502122		gb: UI-HF-BR0p-ajr-c-08-0-Ul.r1 NIH_MGC_5	9.284E−05	3.36	39.5
415897	H08323	Hs. 268712	ESTs	7.148E−04	3.35	30
456782	AK000462	Hs. 132071	ovarian carcinoma immunoreactive antigen	1.409E−04	3.35	38.75
417732	R36065		gb: yg69h06.r1 Soares infant brain 1NIB H	7.852E−04	3.31	31.25
402273			Target Exon	2.933E−02	3.30	34
440535	AI590563	Hs. 125910	ESTs	1.339E−02	3.30	32.75
450799	AW407504		gb: UI-HF-BM0-adk-g-12-0-Ul.r1 NIH_MGC_38	1.768E−03	3.27	42.5
403508			Target Exon	2.106E−02	3.25	36
443725	AW245680	Hs. 9701	growth arrest and DNA-damage-inducible,	5.085E−06	3.24	412.5
427536	BE277141	Hs. 115803	gb: 601178666F1 NIH_MGC_20 Homo sapiens c	9.859E−04	3.20	38
447306	AI373163	Hs. 170333	ESTs	2.254E−02	3.17	39.5
430071	AA355986	Hs. 232068	transcription factor 8 (represses interl	1.243E−03	3.15	142.75
410052	AA525225	Hs. 334630	Homo sapiens cDNA FLJ14462 fis, clone MA	1.903E−02	3.11	107.75
408952	S79854	Hs. 49322	deiodinase, iodothyronine, type III	2.471E−04	3.09	35.5
447819	U90544	Hs. 19710	solute carrier family 17 (sodium phospha	4.558E−02	3.07	30.5
433010	AW970018		gb: EST382097 MAGE resequences, MAGK Homo	2.492E−03	3.05	36.5
442364	AA993149	Hs. 129895	ESTs, Moderately similar to TBX3_HUMAN T	2.193E−03	3.05	32.5
403582			Target Exon	5.956E−02	3.02	33.75
449180	AI633836	Hs. 195649	ESTs	5.785E−02	3.02	30.25
415994	NM_002923	Hs. 78944	regulator of G-protein signalling 2, 24k	5.146E−02	3.02	117
447135	T58148		gb: yb98g06.s1 Stratagene lung (937210) H	2.012E−03	3.00	62.5
419555	AA244416		gb: nc07d11.s1 NCI_CGAP_Pr1 Homo sapiens	2.196E−03	2.99	95.5
412568	AI878826	Hs. 74034	caveolin 1, caveolae protein, 22 kD	3.035E−02	2.98	61
444047	AI097452	Hs. 135095	ESTs	1.900E−02	2.97	35.5
403180			Target Exon	3.858E−04	2.96	38.75
402777			C1002652*: gi|544327|sp|Q04799|FMO5_RABIT	1.117E−02	2.94	41.25
433095	AK001092	Hs. 302480	Homo sapiens cDNA FLJ10230 fis, clone HE	1.902E−02	2.93	33.75
402070			Target Exon	7.109E−03	2.89	35.5
402124			NM_031891: Homo sapiens cadherin 20, type	8.621E−04	2.88	36.25
402663			C1002133: gi|12697931|dbj|BAB21784.1| (AB	8.917E−03	2.88	30.5
447721	BE619620		lysyl oxidase	1.845E−03	2.85	32.25
422017	NM_003877	Hs. 110776	STAT induced STAT inhibitor-2	3.480E−03	2.84	108
432877	AW974111	Hs. 292477	ESTs	4.422E−02	2.84	67
444863	AW384082	Hs. 104879	serine (or cysteine) proteinase inhibito	2.331E−02	2.80	37.5
444207	AI565004	Hs. 343475	cathepsin D (lysosomal aspartyl protease	4.591E−05	2.80	194
428568	AC004755	Hs. 302038	Homo sapiens chromosome 19, fosmid 37502	7.492E−04	2.80	46.25
424042	Y10601	Hs. 137674	ankyrin-like with transmembrane domains	7.392E−03	2.78	35.25
440509	BE410132	Hs. 134202	ESTs, Weakly similar to T17279 hypotheti	4.906E−04	2.78	94.75
459721	AI299050	Hs. 143835	gb: qn14d12.x1 NCI_CGAP_Lu5 Homo sapiens	4.287E−02	2.78	37.75
402651			NM_000721*: Homo sapiens calcium channel,	2.705E−03	2.77	51
403545			Target Exon	2.012E−03	2.77	43
416666	H73028	Hs. 268992	ESTs	1.549E−03	2.74	32.25
447981	R53772	Hs. 8929	hypothetical protein FLJ11362	4.160E−02	2.74	37
453560	AA348626	Hs. 5890	hypothetical protein FLJ23306	4.700E−02	2.74	41.75
441269	AW015206	Hs. 178784	ESTs	4.422E−02	2.72	64
441427	BE550625	Hs. 126956	ESTs	4.030E−04	2.72	34
411283	AW852754		gb: PM1-CT0247-180100-009-c05 CT0247 Homo	1.337E−02	267	33.5
423433	AK000497	Hs. 128646	hypothetical protein FLJ20639	7.487E−02	2.66	34
421993	R22497	Hs. 110571	growth arrest and DNA-damage-inducible,	4.117E−05	2.65	371
442702	AW235697	Hs. 130980	ESTs	2.107E−02	2.65	38.25
414890	BE281095	Hs. 77573	uridine phosphorylase	1.084E−03	2.61	52.25
401346	BE041451		hypothetical protein	9.633E−03	2.60	46.5
408112	AW451982	Hs. 248613	ESTs	3.674E−02	2.60	40.75
432745	AI821926		gb: nt78f05.x5 NCI_CGAP_Pr3 Homo sapiens	4.904E−04	2.56	32.75
404717			NM_007313*: Homo sapiens v-abl Abelson mu	8.134E−02	2.56	30.75
437180	BE180234	Hs. 281462	Homo sapiens cDNA FLJ14793 fis. clone NT	5.867E−03	2.53	63
417213	BE257508	Hs. 24719	modulator of apoptosis 1	2.923E−05	2.52	38.75
422743	BE304678	Hs. 119598	ribosomal protein L3	1.837E−02	2.50	42.75
457148	AF091035	Hs. 184627	KIAA0118 protein	7.111E−03	2.50	60.25
417079	U65590	Hs. 81134	interleukin 1 receptor antagonist	1.839E−02	2.49	216.5
427899	AA829286	Hs. 332053	serum amyloid A1	9.814E−05	2.48	799
427413	BE547647	Hs. 177781	hypothetical protein MGC5618	1.159E−02	2.48	92.25
422924	AI480125	Hs. 185777	ESTs	9.609E−03	2.48	30.25
412429	AV650262	Hs. 75765	GRO2 oncogene	1.649E−06	2.47	246.25
407654	AW064121	Hs. 279175	ESTs	1.297E−03	2.46	40.5
447650	AW581199	Hs. 161137	ESTs, Moderately similar to I54374 gene	1.292E−02	2.45	40.5
434180	AA921757	Hs. 116180	ESTs	9.459E−04	2.45	50.25
414141	BE255083	Hs. 145729	hypothetical protein DKFZp564A1164	6.099E−03	2.42	30.5
410204	AJ243425	Hs. 326035	early growth response 1	1.419E−03	2.41	232
446912	AI347650	Hs. 128521	ESTs, Moderately similar to ALU4_HUMAN A	2.408E−02	2.40	37.25
448429	D17408	Hs. 21223	calponin 1, basic, smooth muscle	5.621E−02	2.40	31.5
423499	AW608884	Hs. 28068	ESTs	3.008E−04	2.40	31.75
424236	AW058114	Hs. 7837	phosphoprotein regulated by mitogenic pa	2.290E−03	2.37	47.5
426521	AF161445	Hs. 170219	hypothetical protein	2.841E−02	2.37	39.25
446378	AI905699	Hs. 239760	citrate synthase	8.200E−04	2.36	50.5
400818			Target Exon	3.204E−03	2.36	46.75
454339	AW381980		gb: QV4-HT0316-091199-028-d05 HT0316 Homo	1.969E−02	2.35	39
401942			C17001396*: gi|3212355|pdb|1A4P|A Chain A	1.759E−03	2.33	36
456147	H41324	Hs. 31581	ESTs, Moderately similar to ST1B_HUMAN S	6.882E−02	2.32	35.5
419305	AI609195	Hs. 304930	ESTs	5.144E−04	2.31	32.75
428403	AI393048	Hs. 326159	leucine rich repeat (in FLII) interactin	7.081E−02	2.30	52
456013	T92048		gb: yd54g12.s1 Soares fetal liver spleen	7.837E−04	2.29	30.25
435992	AI033259	Hs. 118317	Homo sapiens cDNA FLJ12088 fis, clone HE	2.663E−02	2.28	50.75
424272	AA360929	Hs. 144439	putative RNA binding protein	3.780E−03	2.28	34
411231	AW833501		gb: QV4-TT0008-091199-025-e09 TT0008 Homo	2.189E−03	2.27	30.5
434651	BE616902	Hs. 285313	core promoter element binding protein	9.321E−02	2.27	45.75
401376			Target Exon	1.773E−02	2.27	37.75
407338	AA773213	Hs. 200558	gb: ab66f10.s1 Stratagene lung carcinoma	1.038E−02	2.26	39.5
402012	AF106069		ubiquitin specific protease 15	9.915E−04	2.25	36
415759	AA169182	Hs. 182740	gb: zp20e02.s1 Stratagene fetal retina 93	9.630E−03	2.25	34.25
431387	AI878854	Hs. 252229	v-maf musculoaponeurotic fibrosarcoma (a	8.945E−03	2.23	35.5
452236	AI130858	Hs. 143218	ESTs	5.457E−02	2.22	31.25
405443			Target Exon	1.202E−02	2.21	132.75
402878			ENSP00000217420*: BA122O1.1 (A novel prot	1.132E−03	2.20	35.5
422831	R02504	Hs. 332943	ESTs	7.682E−03	2.20	39.75
410895	AW809679		gb: MR4-ST0124-261099-015-f05 ST0124 Homo	2.489E−02	2.20	34.75
405022			Target Exon	5.299E−02	2.19	33.75
403750			C5001092: gi|6671939|gb|AAF23199.1|AC0167	4.249E−03	2.19	30.75
404187			NM_019602: Homo sapiens butyrophilin-like	9.022E−04	2.19	53.25
420701	N42919	Hs. 88630	ESTs, Weakly similar to T14748 hypotheti	9.286E−03	2.19	31.75
434495	AW352170	Hs. 129086	Homo sapiens cDNA FLJ12007 fis, clone HE	9.997E−03	2.16	38.5
427700	AA262294	Hs. 180383	dual specificity phosphatase 6	3.340E−02	2.15	84
416348	H65887	Hs. 272163	ESTs	3.497E−04	2.15	30.5
426653	AA530892	Hs. 171695	dual specificity phosphatase 1	3.337E−04	2.14	399.5
440249	AI246590	Hs. 249175	ESTs	9.290E−05	2.14	53.75
458568	AI769067	Hs. 127824	ESTs, Weakly similar to T28770 hypotheti	1.340E−02	2.11	395.75
459711	BE386801	Hs. 21858	trinucleotide repeat containing 3	4.562E−02	2.10	37.5
409540	AW409569		gb: fh01e09.x1 NIH_MGC_17 Homo sapiens cD	2.287E−03	2.09	41.75
437389	AL359587	Hs. 271586	hypothetical protein DKFZp762M115	3.208E−03	2.09	87.75
455968	BE168828		gb: QV1-HT0517-020400-145-f04 HT0517 Homo	1.237E−03	2.08	50.5
419909	AL136653	Hs. 93675	decidual protein induced by progesterone	2.488E−03	2.07	80.25
407869	AI827976	Hs. 24391	hypothetical protein FLJ13612	1.358E−03	2.07	199
456465	M94065	Hs. 94925	dihydroorotate dehydrogenase	5.155E−04	2.07	121.75
412541	BE009398	Hs. 74002	nuclear receptor coactivator 1	9.647E−03	2.04	41.25
423935	BE382429	Hs. 268561	hypothetical protein FLJ10726	1.246E−02	2.03	38.75
408022	AW137208	Hs. 176000	ESTs	2.571E−02	2.03	42.25
406140			Target Exon	1.081E−03	2.03	48
417076	AW973454	Hs. 238442	ESTs, Moderately similar to ALU7_HUMAN A	9.630E−03	2.02	31.5
442321	AF207664	Hs. 8230	a disintegrin-like and metalloprotease (	1.926E−04	2.02	187
431111	AB033072	Hs. 250015	KIAA1246 protein	1.272E−04	2.01	37.25
445132	Z44811	Hs. 14928	hypothetical protein FLJ12903	5.935E−04	2.01	49
438808	M73980	Hs. 129053	Homo sapiens NOTCH 1 (N1) mRNA, complete	2.703E−03	2.01	34.25
406210			Target Exon	2.179E−02	2.01	34.5
422424	AI186431	Hs. 296638	prostate differentiation factor	2.333E-02	2.00	153.5
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of Hep C− Liver over Trimean of Hep C+ liver Ratio
R3: Difference of Trimean of Hep C− Liver vs. Trimean of Hep C+ Liver

[0346]

TABLE 4B
Pkey	CAT Number	Accession
409540	1138613_1	AW409569 BE297044 BE295828
409840	1156071_1	AW502122 AW502125 AW501663 AW501720
410895	1226051_1	AW809679 AW809678 AW810113 AW810182 AW809900 AW809851 AW810110 AW810228 AW810342 AW810181
		AW809632 AW809745
		AW810372 AW809681 AW809792 AW809806 AW810452 AW809675 AW809964 AW810033 AW810111
		AW809846 AW809847 AW809717
411231	1236356_1	AW833501 AW833506 AW833722 AW833332 AW833509 AW833511 AW833767 AW833339
411283	1237666_1	AW852754 AW852897 AW852757 AW852617 BE172755 AW835444
411349	1239900_1	AW838313 AW838353 AW838382 AW838207
412176	1281370_1	AW898334 H66426 AW899792
417732	1695922_1	R36065 R12062 R12616 Z43412
419555	185884_1	AA244416 AA244401
423053	224319_1	BE312679 BE314223 AA320990
429258	301917_1	AA448765 C04967 C03045 AA658293
432745	353673_1	AI821926 AA658826 AA564492 AA635129 AI791191
433010	357372_1	AW970018 AA573669 AA573622 R08736
446052	65988_1	AA358760 AA158850 AW062737 AW062738 AV656291
447135	70963_1	T58148 AW516579 AW059603
447721	73383_1	BE619620 AA448721 AI971709 AW175624 W24193 W24199 BE463718 AW193322 AI341487 AW072844
		BE048584 AW593800 AI623222
		AI983635 AW275114 AI952164 AI800442 AA385255 AW959076 AA977038 AI801910 AW513859 AW273202 AW337946
		AA250733 AW273147
		AI453134 AW235230 AI818468 AW166266 AI086791 AW300481 AI631778 AI561259 AW470887 AI207341
		AW103087 AW193240 AI052433
		AI128968 AW264492 AA327876 AI682412 AW771868 AI669677 AA448630 AA456607 AI128695 AI825128
		AW195959 N79049 AI470892
		AA902669 AI672486 AA769789 AI214684
449986	821463_1	AW864502 AW864369 AI678780
450799	847242_1	AW407504 W31274 AI738877
454339	1122972_1	AW381980 BE152244 BE152235 BE152238 BE152232
454598	1226062_1	AW809716 AW810152 AW809646 AW809747 AW809738 AW809826 AW809996 AW809798 AW809802 AW809840
		AW809695
454636	1227589_1	AW811502 AW811521 AW811548 AW811471 AW811511 AW811508
454985	1248105_1	AW849292 AW849431 AW849422 AW849428 AW849420 AW849424 AW849427
455968	1391117_1	BE168828 BE168830 BE168823 BE168928 BE168820 BE168826
456013	1411982_1	T92048 BE242744
458867	80304_1	AW995393 AJ403118
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0347]

TABLE 4C
Pkey	Ref	Strand	Nt_position
400818	8569994	Plus	172644-172765, 173085-173200
401149	7229925	Plus	73117-74019
401346	9926605	Minus	12031-13032
401376	7417809	Plus	40584-40963
401677	9965537	Minus	62856-63086, 63603-63884
401913	9369520	Minus	33753-33904
401942	4982556	Minus	130749-131044
402012	7407997	Minus	111771-111909, 112107-112226,
			112519-112694
402070	8117335	Minus	68256-68484
402124	4033680	Plus	164206-164459
402273	2979528	Plus	28990-29203, 32299-32402,
			32474-32668
402517	9798106	Plus	17569-17721
402651	7960391	Plus	174215-174380
402663	8077020	Minus	14155-14364
402777	9588235	Plus	126786-126948
402878	9908870	Minus	56133-56522
402889	9931133	Plus	89392-89498, 90358-90571
403180	7523976	Minus	63603-63759
403324	8440025	Minus	107104-107309
403508	7630896	Plus	5570-5719
403545	8078400	Plus	25293-25640
403579	8101179	Minus	36167-36365
403582	8101186	Plus	18308-18458
403750	7229814	Minus	133638-134110
403794	8096910	Plus	163292-163884
403796	8099896	Minus	75073-77664
404187	4481839	Plus	7644-7991
404501	7229859	Minus	37270-37526
404717	9838068	Minus	165900-166052, 169415-169599,
			171430-171607, 172254-172338
404958	7407941	Minus	2731-4531
405022	7330304	Plus	217163-217439
405278	6139075	Minus	3863-3965, 4823-4891, 5439-5529,
			6043-6170, 6344-6562, 7835-7990
405443	7408143	Plus	90716-90887, 101420-101577
405600	5923640	Plus	26662-27225
406140	9168231	Minus	49887-50219
406210	7341959	Plus	58546-58687
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0348] Table 5A lists about 164 genes up-regulated in Hepatitis C positive liver tissues at a time before pegylated-interferon-alpha plus ribavirin treatment that was found to be non-responsive (non-responders) to the treatment compared to Hepatitis C positive liver tissues at a time before pegylated-interferon-alpha plus ribavirin treatment that was found to be responsive to the treatment (responders). These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of non-responders to the “weighted average” of responders was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the non-responders was set to the trimean of the non-responders. The “weighted average” of the responders was set to the either 10 or the trimean of the different responders, whichever value was greater to eliminate ratios with a denominator of zero or less. Tables 5B and 5C relate to Table 5A as 3B and 3C relate to 3A.

TABLE 5A
Pkey	ExAccn	UnigeneID	Unigene Title	R1	R2	R3
454075	R43826	Hs. 16313	Kruppel-like zinc finger protein GLIS2	6.136E−02	7.15	64.75
430273	AI311127	Hs. 125522	ESTs	7.404E−02	6.35	60
444342	NM_014398	Hs. 10887	similar to lysosome−associated membrane	5.766E−03	6.25	77.5
424381	AA285249	Hs. 146329	protein kinase Chk2	3.476E−02	6.17	52.75
444104	AW296150	Hs. 177151	ESTs	7.353E−02	5.97	57
447261	NM_006691	Hs. 17917	extracellular link domain-containing 1	5.091E−02	5.33	53
426990	AL044315	Hs. 173094	Homo sapiens mRNA for KIAA1750 protein,	7.404E−02	5.31	52.75
404493	NA		Target Exon	1.485E−02	5.13	42
412747	AW994222		gb: RC3-BN0036-250200-012-e02 BN0036 Homo	5.091E−02	5.07	51.75
404075	NA		Target Exon	5.132E−02	4.97	41
454525	BE280421	Hs. 94499	ESTs	5.681E−03	4.95	50.5
445098	AL050272	Hs. 12305	DKFZP566B183 protein	1.812E−02	4.92	39.25
402012	AF106069		ubiquitin specific protease 15	7.404E−02	4.91	44
452826	BE245286	Hs. 301636	peroxisomal biogenesis factor 6	2.299E−02	4.91	62.5
407828	AW959500	Hs. 49597	retinoic acid induced 2	4.200E−02	4.75	49.5
417123	BE326521	Hs. 159450	ESTs	3.381E−02	4.70	43.25
418483	W26076	Hs. 221847	ESTs	5.132E−02	4.70	41.25
414308	AI740705	Hs. 126485	hypothetical protein FLJ12604; KIAA1692	5.051E−02	4.55	42.25
426106	AI678765	Hs. 21812	ESTs	3.476E−02	4.49	53.25
437233	D81448	Hs. 339352	Homo sapiens brother of CDO (BOC) mRNA,	6.136E−02	4.47	59.25
403807	NA		NM_031889: Homo sapiens enamelin (ENAM),	5.681E−03	4.34	36.75
432250	AA452088	Hs. 274170	Opa-interacting protein 2	1.833E−02	4.32	39.75
452455	N25153	Hs. 61661	ESTs, Weakly similar to AF174605 1 F-box	2.251E−02	4.25	40
459171	AW967801	Hs. 64783	ESTs, Weakly similar to T42705 hypotheti	5.132E−02	4.17	35.5
435791	AA243086	Hs. 25204	chondroitin 4-O-sulfotransferase 2	1.485E−02	4.17	41.25
426798	AA385062	Hs. 130260	ESTs	5.132E−02	4.13	32.5
424017	AA333789		gb: EST37925 Embryo, 9 week Homo sapiens	6.136E−02	4.10	35.25
446627	AI973016	Hs. 15725	hypothetical protein SBBI48	3.476E−02	4.06	72
442269	AI797066	Hs. 201995	ESTs	1.450E−02	4.05	31
447698	AI420156	Hs. 326733	ESTs	1.168E−02	4.05	47.25
432336	NM_002759	Hs. 274382	protein kinase, interferon-inducible dou	7.404E−02	4.02	35
408711	AW376061	Hs. 63335	ESTs, Moderately similar to A46010 X-lin	7.404E−02	4.02	31
427867	NM_005073	Hs. 2217	solute carrier family 15 (oligopeptide t	8.877E−03	3.97	49.5
437990	AI686579	Hs. 121784	ESTs	5.132E−02	3.97	34
444640	AL133933	Hs. 64310	interleukin 11 receptor, alpha	7.353E−02	3.97	30.75
437063	AA351109	Hs. 5437	Tax1 (human T-cell leukemia virus type I	7.404E−02	3.95	33.25
428108	AA421452		ESTs, Weakly similar to KIAA0926 protein	2.807E−02	3.95	31.5
412055	AA099907	Hs. 271806	ESTs, Weakly similar to ALU1_HUMAN ALU S	5.091E−02	3.93	33
417936	X01059	Hs. 82963	gonadotropin-releasing hormone 1 (leutin	4.200E−02	3.92	37.5
410099	AA081630		KIAA0036 gene product	1.485E−02	3.91	80.75
410541	AA065003	Hs. 64179	syntenin-2 protein	5.766E−03	3.85	123.25
424259	AK001776	Hs. 143954	hypothetical protein FLJ10914	2.299E−02	3.82	39.75
458381	AI041873	Hs. 132148	ESTs	5.132E−02	3.82	36.25
441897	AI264686	Hs. 23921	hypothetical protein DKFZp547A023	5.091E−02	3.77	42.75
405411			ENSP00000252213: SODIUM BICARBONATE COTRA	5.132E−02	3.75	64.25
427509	M62505	Hs. 2161	complement component 5 receptor 1 (C5a I	3.476E−02	3.75	30.25
428151	AA422028	Hs. 171136	ESTs	3.476E−02	3.72	32
422553	AI697720	Hs. 171455	ESTs, Weakly similar to T31613 hypotheti	5.091E−02	3.69	78
401842	NA		Target Exon	7.404E−02	3.67	38
433365	AF026944	Hs. 293797	ESTs	5.091E−02	3.65	68
402200	AL080200		DKFZP434F122 protein	2.275E−02	3.65	41
437191	NM_006846	Hs. 331555	serine protease inhibitor, Kazal type, 5	6.136E−02	3.63	31.75
444196	AW139633	Hs. 279582	GTP-binding protein Sara	5.132E−02	3.60	35
403436			NM_006548*: Homo sapiens IGF-II mRNA-bind	2.299E−02	3.59	39.5
435128	AF176832	Hs. 47005	low density lipoprotein-related protein	5.681E−03	3.57	39.25
422240	R60594	Hs. 29002	KIAA1706 protein	5.132E−02	3.57	32.75
431726	NM_015361	Hs. 268053	KIAA0029 protein	3.444E−02	3.52	30.25
407366	AF026942	Hs. 271530	gb: Homo sapiens cig33 mRNA, partial sequ	1.485E−02	3.51	91
404109			C6000844*: gi|7497891|pir||T20194 hypothe	1.468E−02	3.50	33
426788	U66615	Hs. 172280	SWI/SNF related, matrix associated, acti	7.404E−02	3.46	32
415822	D59243		gb: HUM526E07B Clontech human placenta po	2.299E−02	3.45	52.25
449922	AA004731		gb: zh93g05.s1 Soares_fetal_liver_spleen—	5.132E−02	3.43	32.75
458159	AA883831	Hs. 252924	ESTs	9.243E−03	3.42	44.5
446650	AB016625	Hs. 15813	solute carrier family 22 (organic cation	5.132E−02	3.42	38.25
450011	AW071789	Hs. 99233	ESTs	5.681E−03	3.42	38
432706	NM_013230	Hs. 286124	CD24 antigen (small cell lung carcinoma	8.760E−02	3.42	34.5
447898	AW969638	Hs. 112318	6.2 kd protein	3.476E−02	3.40	46.75
439478	AF049460	Hs. 6574	deformed epidermal autoregulatory factor	3.476E−02	3.36	50.25
414709	AA704703	Hs. 77031	Sp2 transcription factor	2.299E−02	3.35	63.5
450404	AA742544	Hs. 159231	hypothetical protein FLJ21551	5.132E−02	3.35	34
429505	AW820035	Hs. 278679	a disintegrin and metalloproteinase doma	3.476E−02	3.25	32.25
440258	AI741633	Hs. 125350	ESTs	9.243E−03	3.24	32.5
449713	AW027025	Hs. 345528	ESTs	3.476E−02	3.24	38
432791	NM_014554	Hs. 66450	sentrin/SUMO-specific protease	7.404E−02	3.22	38.5
408570	AL046406	Hs. 103483	KIAA1798 protein	7.302E−02	3.22	38
403512	NA		C3000579*: gi|12643308|sp|Q9Y4K1|AIM1_HUM	1.485E−02	3.13	46.75
406303			C16000922: gi|7499103|pir||T20903 hypothe	3.444E−02	3.07	30.5
449137	AW134478	Hs. 196033	ESTs	7.268E−03	3.05	52
401807			C7001350: gi|6578126|gb|AAF17706.1|AF0496	5.132E−02	3.05	31.5
423748	AI149048	Hs. 30211	hypothetical protein FLJ22313	5.132E−02	3.02	38
448497	BE613269	Hs. 21893	hypothetical protein DKFZp761N0624	1.168E−02	3.02	34.25
447164	AF026941	Hs. 17518	Homo sapiens cig5 mRNA, partial sequence	5.132E−02	2.98	128
450446	AI696334	Hs. 14450	ESTs	1.468E−02	2.97	43.75
435938	AI248774	Hs. 126707	hypothetical protein FLJ11457	4.970E−02	2.97	35.5
422744	AW268803	Hs. 119640	hBKLF for basic kruppel like factor	4.128E−02	2.97	34.5
453397	AA035378	Hs. 31222	ESTs, Weakly similar to DRPL_HUMAN ATROP	5.132E−02	2.96	34.25
454204	AW816498		gb: QV0-ST0236-171299-075-b02 ST0236 Homo	3.444E−02	2.95	30.25
443041	AA558677	Hs. 8928	hypothetical protein FLJ20291	2.299E−02	2.93	40.5
422366	T83882	Hs. 97927	ESTs	4.164E−02	2.92	31.75
429982	AW449534	Hs. 99607	hypothetical protein FLJ13841	9.366E−03	2.77	51.25
447278	AI934935	Hs. 158669	ESTs	8.760E−02	2.77	33.75
431250	BE264649	Hs. 251377	taxol resistance associated gene 3	7.404E−02	2.76	85.5
419270	NM_005232	Hs. 89839	EphA1	7.404E−02	2.76	45.75
425109	R37456	Hs. 184793	Homo sapiens cDNA: FLJ21880 fis, clone H	3.349E−02	2.75	35
417214	AW192804	Hs. 24719	modulator of apoptosis 1	5.766E−03	2.74	52.25
430259	BE550182	Hs. 127826	RalGEF-like protein 3, mouse homolog	5.766E−03	2.74	37.75
427765	AA412247	Hs. 111970	ESTs	5.132E−02	2.72	33.5
409947	AA078629	Hs. 27301	ESTs	3.444E−02	2.72	37
443493	AI074053	Hs. 127146	ESTs	3.349E−02	2.71	35
449394	AA004368	Hs. 18160	Homo sapiens cDNA FLJ11550 fis. clone HE	3.476E−02	2.70	45.75
405348	NA		C7001664: gi|12698061|dbj|BAB21849.1| (AB	3.476E−02	2.70	42.75
448030	N30714	Hs. 325960	membrane-spanning 4-domains, subfamily A	1.468E−02	2.68	39
418203	X54942	Hs. 83758	CDC28 protein kinase 2	5.132E−02	2.66	42.75
422833	BE141312		gb: MR0-HT0078-051099-002-h06 HT0078 Homo	1.468E−02	2.65	38.75
448124	AI470454	Hs. 199150	ESTs	3.444E−02	2.60	37
401536			NM_002530*: Homo sapiens neurotrophic tyr	8.760E−02	2.53	41.75
456370	AA234938	Hs. 87384	ESTs	3.476E−02	2.50	52.25
404607	NA		Target Exon	5.132E−02	2.50	48.5
436729	BE621807		transmembrane 4 superfamily member 1	7.353E−02	2.49	35
404801			NM_004286*: Homo sapiens GTP binding prot	2.299E−02	2.46	50.25
414173	N27495	Hs. 5565	hypothetical protein FLJ22626	2.275E−02	2.45	39.75
413719	BE439580	Hs. 75498	small inducible cytokine subfamily A (Cy	3.476E−02	2.45	64
413550	W03011	Hs. 306881	MSTP043 protein	8.705E−02	2.44	32.75
405416			C19001058*: gi|5080758|gb|AAD39268.1|AC00	3.476E−02	2.42	31.25
458388	W28887	Hs. 133142	Homo sapiens cDNA: FLJ22153 fis, clone H	7.404E−02	2.42	30.5
432886	BE159028	Hs. 279704	chromatin accessibility complex 1	1.485E−02	2.41	34.25
419497	NM_006410	Hs. 90753	Tat-interacting protein (30 kD)	8.760E−02	2.40	33.5
443743	AI084210	Hs. 303925	ESTs, Weakly similar to A46010 X-linked	8.760E−02	2.39	34.5
444811	AW137791	Hs. 148419	ESTs	1.485E−02	2.39	41
430291	AV660345	Hs. 238126	CGI-49 protein	7.404E−02	2.39	41
459119	AW844498	Hs. 306121	CDC20 (cell division cycle 20, S. cerevi	5.132E−02	2.38	38.75
432195	AJ243669	Hs. 8127	KIAA0144 gene product	3.476E−02	2.37	44.75
416046	H16054	Hs. 297644	ESTs	8.705E−02	2.36	46.5
421650	AA781795	Hs. 122587	ESTs	3.444E−02	2.35	59.5
455886	BE153549	Hs. 293818	ribosomal protein L7	5.132E−02	2.34	40
409775	AW499605		gb: UI-HF-BP0p-ain-c-05-O-Ul.r1 NIH_MGC_5	5.132E−02	2.32	49
402601			Target Exon	5.132E−02	2.31	55.5
439602	W79114	Hs. 58558	ESTs	7.353E−02	2.30	41
458946	AA009716	Hs. 42311	ESTs	6.136E−02	2.30	32.75
419445	AA884471	Hs. 90449	Human clone 23908 mRNA sequence	3.476E−02	2.30	31.5
439242	BE167324	Hs. 53996	ESTs, Weakly similar to ZN42_HUMAN ZINC	9.243E−03	2.29	50.5
444301	AK000136	Hs. 10760	asporin (LRR class 1)	5.132E−02	2.28	50.75
435706	W31254	Hs. 7045	GL004 protein	7.404E−02	2.27	46.5
405418	NA		Target Exon	5.766E−03	2.27	53.25
452032	BE244005	Hs. 27610	retinoic acid- and interferon-inducible	7.268E−03	2.25	53.5
444830	AI198854	Hs. 145437	ESTs	6.136E−02	2.24	32
428075	AW205525	Hs. 212511	ESTs	5.132E−02	2.23	48.75
446169	AA398857	Hs. 14142	nudix (nucleoside diphosphate linked moi	9.366E−03	2.23	31.25
453405	AI567972		ESTs, Highly similar to AF161437 1 HSPC3	7.302E−02	2.22	48
441942	AF182645	Hs. 8024	IK cytokine, down-regulator of HLA II	7.404E−02	2.19	38.5
417640	D30857	Hs. 82353	protein C receptor, endothelial (EPCR)	7.353E−02	2.19	37.5
425225	NM_003450	Hs. 155204	zinc finger protein 174	2.251E−02	2.18	40.25
430227	AI924441	Hs. 236218	TAT-INTERACTIVE PROTEIN, 72-KD	7.404E−02	2.17	49.5
458704	AI343613	Hs. 156600	ESTs	4.200E−02	2.17	33.25
404973	NA		Target Exon	5.091E−02	2.16	47.25
448362	AA641767	Hs. 21015	hypothetical protein DKFZp564L0864 simil	1.485E−02	2.14	37
428315	AA688152	Hs. 98505	ESTs	6.091E−02	2.13	44.75
415749	BE262529	Hs. 78771	phosphoglycerate kinase 1	7.166E−03	2.12	39
419104	AA709154	Hs. 191514	ESTs	5.132E−02	2.11	33
437849	AA769680	Hs. 18768	ESTs	3.476E−02	2.11	36.25
428726	AA432195	Hs. 98694	ESTs	5.132E−02	2.09	43.25
440495	AA887212	Hs. 14161	hypothetical protein DKFZp43411930	1.485E−02	2.08	41.75
446337	AW272746	Hs. 239818	phosphoinositide-3-kinase, catalytic, be	5.132E−02	2.07	39.5
404975	AL042279		uncharacterized hypothalamus protein HT0	7.302E−02	2.06	38.25
415599	Z44487	Hs. 8763	gb: HSC21F081 normalized infant brain cDN	7.353E−02	2.05	34.75
416404	AA180138	Hs. 107924	ESTs	7.404E−02	2.05	41.5
439277	R80061	Hs. 164478	hypothetical protein FLJ21939 similar to	8.649E−02	2.05	33.75
430108	AA465294	Hs. 291750	ESTs	1.485E−02	2.05	31.5
422746	NM_004484	Hs. 119651	glypican 3	7.404E−02	2.02	144.5
458410	H20380	Hs. 200250	ESTs, Moderately similar to ALU7_HUMAN A	8.760E−02	2.01	39.25
410204	AJ243425	Hs. 326035	early growth response 1	1.485E−02	2.01	148.75
441616	BE569122		RNA-binding protein (autoantigenic)	5.091E−02	2.01	31.25
414395	BE304888	Hs. 279834	EST	7.353E−02	2.00	40.25
456999	AA319798	Hs. 298581	eukaryotic translation elongation factor	3.476E−02	2.00	31.25
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of non-responders over Trimean of responders Ratio
R3: Difference of Trimean of non-responders vs. Trimean of responders

[0349]

TABLE 5B
Pkey	CAT Number	Accession
409775	1154112_1	AW499605 AW501372 AW503065 AW500923 AW501639
410099	117647_1	AA081630 T08671 AI174254 D83874 AW959843 AA364503
		AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980
		W52882 T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237
		AA917004 AA716027 AI439658 AA283724 AI805992
		AI457096 AA084618 BE467736 AI092635 AI887863 AI697593 AA436618 AI167419
		AI418634 T31586 AA436630 AA706191 AI041169
		AI422304 T03534 AA211402 AI204899 AI366472 AW827081 AA788593 T32736
		AI767935 AA167791 AA747914 AA663870 AI865504
412747	1324696_1	AW994222 AW994377
415822	155791_1	D59243 D63202 AA169716
422833	221904_1	BE141312 BE141417 BE141389 AA317747
424017	234338_1	AA333789 AA334317 AW966107
428108	287154_1	AA421452 BE302040 AI204456 AA833751 AA421483 AI825059
436729	42585_1	BE621807 AI445461 AI346835 AI453743 AI564644 AI928364 AW984527 BE156214
		AI694111 AI591358 C17504 C17476 C17963 C18304
		AW071625 AI678712 C17732 D57559 H61762 AI720939 AI262930 H27252 AA479712
		AI927769 AA291465 AA155661 AI963432 AI567995
		AA421678 AI925607 AA292956 AA192448 AW192593 AI865838 AI696905 AI871950
		AI911921 BE619741 BE439796 AI161312 AI597801
		AI424384 AI093510 AI240988 AW820230 AI492554 BE044033 AW262737 AW008570
		AA043216 AW629505 AA136645 AA037722 AA706057
		AA088439 AW806193 AW806183 AA479834 BE501957 AA129574 R38114 AA649494
		AA524526 BE327120 AW572531 BE219784 BE349186
		AW015724 AA043217 AW772000 AI799814 AI671727 AW779725 AA502832 AI470033
		AA129575 W38161 AI972739 AA404570 AA627686
		AA723200 AA147228 AA903050 AI990245 AI075878 T32487 C06123 AA157944 AI800106
		W60075 AI859160 AA478328 AW673152 AA182640
		AI990827 AW275048 AW103470 AI298935 AW471421 R79190 AW085158 W45410
		AW300456 AA662517 T55840 AI823466
		AI692846 AA962397 AW191997 AA136658 AI251817 BE044134 AW339104 AW517762 AA724739
		R79933 AA411100 AA191349 AA037696
		AA190966 AA757735 AW772283 AA010631 H80983 AI769516 H64985 AI061065 AI950693
		AA085492 AI245632 H28594 AW088968 BE156360
		AI349390 AI621320 AI738844 AW194272 AA148284 AA953883 C06365 AA487893
		AI927217 AI918523 AI453453 AI798502 AI189366
		AI261359 AI032569 AW338678 AI972899 AI500576 AI872628 AI693030 Z28771
		AI985583 AI363829 AW339301 AA581093 AI650338 W60032
		AA603586 AI686240 AW242958 AA719173 AI745717 AW675302 AI582462 AI244845
		AI565439 F09579 AI918453 AA035576 AI472527
		AW351556 AA191414 AW674145 D57558 AI446740 D57845 AI589264 C05782 AA722206
		AI432033 R21752 BE157510 AI829640 AI468237
		AW384233 AA989662 AI865912 AW197954 AI344941 X75684 AI344943 AW583310 AA988297
		AI334860 AI348877 AI798415 D11921
		AI377596 AI983655 AI744233 C06111 AI248307 AA948565 AI224807
441616	52161_2	BE569122 BE43964 BE621682 BE548066 N73920 AA164369 W80481
		AI301065 N36665 AW071970 AW263496 AI499701 AA001425
		AA781414 AI479737 AA922117 AW104450 AA026632 N30835 AW274584 AW173171 AW817587
		R94765 AA019198 AA054252 H03499
		AA954721 AI926512 AI685317 AI393574 AW166832 AA742324 AI749979 AA972701 AA434451
		AI305153 AA678370 F12140 H16890 AI356800
		AW613806 R73589 AI280399 AW627592 AI334386 AI200095 W47269 AI491703 AA837589 AI073728
		AI367984 AI422897 AI282124 AA053948
		AI218584 H84116 AI273274 AA731678 AW338258 AI347082 AA256494 AW022998
		AA743354 AI698561 R69295 AI280442 AA480586
		AA026691 AI948431 AI381988 AA417566 BE564055 AA365458 AA054003
449922	81925_1	AA004731 AA004787 AI240768
453405	96607_1	AI567972 AW196160 AA035448 AA934760 N70743 AA862404 AA485737
		AA885091 AI926381 AA885115 AA284561 AA284560 C00839
		W01732
454204	1050597_1	AW816498 AW808791 AW808515 AW808379 AW808532 AW808605 AW808977
		AW808816 AW178676 AW178486 AW808514 AW178483
		AW178485 AW809007 AW808524
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0350]

TABLE 5C
Pkey	Ref	Strand	Nt_position
401536	7960358	Plus	100193-100336, 103486-103671
401807	7331536	Plus	152325-152912
401842	7684597	Plus	111602-111746
402012	7407997	Minus	111771-111909, 112107-112226,
			112519-112694
402200	7689783	Plus	28877-29398
402601	7705237	Minus	170567-170936, 171175-171610,
			173128-173238, 173317-173425,
			173505-173766
403436	9719642	Minus	96248-96361, 98626-98757
403512	7656757	Minus	114487-114610
403807	8439933	Minus	162963-165773
404075	7652011	Plus	53692-53938
404109	9211742	Minus	144675-144928, 151899-152064
404493	8140670	Plus	38930-39208
404607	7328770	Plus	28477-28591
404801	4582132	Plus	89110-89482, 94224-94347
404973	3213020	Plus	101602-102591
404975	3419864	Minus	86096-86605
405348	2914717	Minus	43310-43462
405411	3451356	Minus	17503-17778, 18021-18290
405416	6984492	Minus	28380-30235
405418	6997292	Plus	51839-51953
406303	8575868	Plus	173622-173786
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0351] Table 6A lists about 284 genes up-regulated in Hepatitis C positive liver tissues at a time before pegylated-interferon-alpha plus ribavirin treatment that was found to be responsive (responders) to the treatment compared to Hepatitis C positive liver tissues at a time before pegylated-interferon-alpha plus ribavirin treatment that was found to be non-responsive to the treatment (non-responders). These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of responders to the “weighted average” of non-responders was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the responders was set to the trimean of different non-responders. The “weighted average” of the non-responders was set to the either 10 or the trimean of different non-responders, whichever value was greater to eliminate ratios with a denominator of zero or less. Tables 6B and 6C relate to Table 6A as 3B and 3C relate to 3A.

TABLE 6A
Pkey	ExAccn	UnigeneID	Unigene Title	R1	R2	R3
433156	R59206	Hs. 17519	Homo sapiens cDNA: FLJ22539 fis, clone H	9.366E−03	9.97	91.25
425701	AA361850	Hs. 322149	Human clone 137308 mRNA, partial cds	2.299E−02	8.90	86.75
453822	NM_014116	Hs. 35416	PRO0132 protein	7.404E−02	8.15	71.75
421160	AL080215	Hs. 102301	Homo sapiens mRNA; cDNA DKFZp586J0323 (f	8.705E−02	7.32	74.5
424375	AF070547	Hs. 146312	Homo sapiens clone 24820 mRNA sequence	7.404E−02	7.27	75
435147	AL133731	Hs. 4774	Homo sapiens mRNA; cDNA DKFZp761C1712 (f	5.766E−03	6.52	104.5
416686	H75435	Hs. 169404	ESTs	3.476E−02	6.47	75.75
451078	AI927694	Hs. 340945	ESTs	5.132E−02	6.47	58.25
432474	AA584042		gb: nn65e09.s1 NCI_CGAP_Lar1 Homo sapiens	3.476E−02	6.40	54
415374	F06904	Hs. 8346	ESTs	2.299E−02	6.30	62.5
427958	AA418000	Hs. 98280	potassium intermediate/small conductance	5.681E−03	5.97	91
408806	AW847814	Hs. 289005	Homo sapiens cDNA: FLJ21532 fis, clone C	1.485E−02	5.82	54.75
401757			Target Exon	2.299E−02	5.77	59.75
400864			Target Exon	5.132E−02	5.63	55.5
432425	AF070619	Hs. 274539	Homo sapiens clone 24481 mRNA sequence	7.404E−02	5.60	65.5
401529			Target Exon	5.132E−02	5.57	47.75
451408	AI795947	Hs. 209596	ESTs	3.476E−02	5.55	60.5
444813	AW054834	Hs. 210356	ESTs	5.132E−02	5.40	57.5
418432	M14156	Hs. 85112	insulin-like growth factor 1 (somatomedi	7.404E−02	5.36	49
419831	AW448930	Hs. 5415	ESTs	7.353E−02	5.17	51.5
436593	AW085002	Hs. 156187	ESTs	2.698E−02	5.13	49
420315	NM_006299	Hs. 96448	zinc finger protein 193	7.353E−02	5.05	54
438098	AI076370	Hs. 134037	ESTs	7.404E−02	5.05	43.5
411755	BE327036	Hs. 117494	ESTs	2.807E−02	5.02	44
442719	H12048	Hs. 91564	ESTs	8.705E−02	5.02	41
449625	NM_014253		odz (odd Oz/ten-m, Drosophila) homolog 1	7.353E−02	4.92	63
407269	AJ245210		gb: Homo sapiens mRNA for immunoglobulin	4.164E−02	4.92	44.25
403609			C3001199: gi|7494834|pir||T15308 hypothet	9.366E−03	4.82	51.25
421417	AA291004	Hs. 326088	ESTs	1.468E−02	4.82	40
400279			NM_004581*: Homo sapiens Rab geranylgeran	3.476E−02	4.81	44.75
435545	AA687415	Hs. 28107	ESTs	5.681E−03	4.72	50.75
445757	AW449065	Hs. 13264	KIAA0856 protein	2.299E−02	4.70	40.75
401593			Target Exon	2.299E−02	4.70	48.5
442552	R20624		son of sevenless (Drosophila) homolog 1	3.476E−02	4.70	45.25
418660	AW161979	Hs. 100914	hypothetical protein FLJ10352	5.132E−02	4.70	39.5
435368	AI056230	Hs. 117122	ESTs	5.766E−03	4.57	83.25
434253	AI393345	Hs. 116215	ESTs	5.091E−02	4.57	49.75
407578	BE464417	Hs. 131035	ESTs, Weakly similar to CA24_HUMAN COLLA	7.404E−02	4.57	48.25
424014	AA333653	Hs. 24790	KIAA1573 protein	9.366E−03	4.55	41
440798	AB020648	Hs. 7426	KIAA0841 protein	5.766E−03	4.52	44.25
426075	AW513691	Hs. 270149	ESTs, Weakly similar to 2109260A B cell	6.136E−02	4.52	43.25
455358	AW902641		gb: QV3-NN1024-100500-181-d08 NN1024 Homo	7.404E−02	4.50	41.75
449621	AI656060	Hs. 195726	ESTs	5.132E−02	4.47	44
459674	AA180511		gb: zp53f03.r1 Stratagene NT2 neuronal pr	7.404E−02	4.42	79
433085	AA781270	Hs. 220943	ESTs	3.444E−02	4.40	50.25
434995	AW974995		gb: EST387100 MAGE resequences, MAGN Homo	7.404E−02	4.40	40
456250	U09196	Hs. 82520	polymerase (DNA-directed), delta 4	7.404E−02	4.38	44.75
425594	AA649842	Hs. 269334	ESTs	2.299E−02	4.38	34.75
402439			C1002445*: gi|4506787|ref|NP 003861.1|IQ	7.404E−02	4.37	43
429355	AW973253	Hs. 292689	ESTs	7.404E−02	4.35	46.75
453751	R36762	Hs. 101282	Homo sapiens cDNA: FLJ21238 fis, clone C	9.366E−03	4.32	63.75
444636	T96667	Hs. 17877	ESTs	5.132E−02	4.30	46.25
401197			ENSP00000229263*: HSPC213.	8.760E−02	4.27	39.25
432014	H66741	Hs. 38540	ESTs, Weakly similar to ALU4_HUMAN ALU S	7.404E−02	4.27	61.25
420556	AA278300	Hs. 124292	Homo sapiens cDNA: FLJ23123 fis, clone L	1.485E−02	4.25	59.75
413329	AI056885	Hs. 133539	ESTs	9.366E−03	4.25	40.25
427450	AB014526	Hs. 178121	KIAA0626 gene product	3.476E−02	4.24	41.25
431858	AA732530	Hs. 184019	Homo sapiens clone 23551 mRNA sequence	1.792E−02	4.22	45.75
408852	AW291435	Hs. 254961	ESTs	1.450E−02	4.22	39.5
433171	AA579425		gb: nf37c08.s1 NCI_CGAP_Pr2 Homo sapiens	3.476E−02	4.20	43.75
430920	U96402	Hs. 248132	goosecoid-like	7.404E−02	4.17	42.75
405206			Target Exon	8.705E−02	4.13	38.75
453815	AL135365	Hs. 126857	Homo sapiens cDNA FLJ12936 fis. clone NT	3.476E−02	4.07	44
440573	BE550891	Hs. 270624	ESTs	5.132E−02	4.05	32.25
411047	AW938479		gb: CM0-DT0057-290200-253-h06 DT0057 Homo	1.468E−02	4.04	39.5
400738			Target Exon	1.833E−02	4.00	36.5
423983	AA333261		gb: EST37476 Embryo, 8 week 1 Homo sapien	2.299E−02	4.00	32.5
403686			C4001366*: gi|9837427|gb|AAG00570.1|AF287	1.485E−02	3.95	39.75
418677	S83308	Hs. 87224	SRY (sex determining region Y)-box 5	1.468E−02	3.94	52.25
453861	AI026838	Hs. 30120	ESTs, Weakly similar to NUCL_HUMAN NUCLE	5.132E−02	3.93	33.75
401778	AA463798		MCT-1 protein	5.766E−03	3.90	40.75
448854	AW245617	Hs. 77703	hypothetical protein FLJ11506	7.404E−02	3.89	32.5
456327	H68741	Hs. 38774	ESTs	3.476E−02	3.85	49.5
431300	AA502346		gb: ne26b03.s1 NCI_CGAP_Co3 Homo sapiens	5.091E−02	3.82	56.75
438146	Z36842	Hs. 57548	ESTs	2.299E−02	3.82	35
443222	AW390067	Hs. 132762	ESTs	2.275E−02	3.82	31.75
457247	AA458605		KIAA1681 protein	9.366E−03	3.82	91.5
406299			Target Exon	5.132E−02	3.80	30
430383	AI861854	Hs. 210778	hypothetical protein FLJ10989	2.275E−02	3.77	49.75
453478	AF083898	Hs. 33021	neuro-oncological ventral antigen 2	6.091E−02	3.77	32
439601	AB029032	Hs. 6606	KIAA1109 protein	7.404E−02	3.76	49.75
421828	AW891965	Hs. 279789	histone deacetylase 3	3.476E−02	3.76	42.75
406528			Target Exon	3.476E−02	3.75	45.5
451614	AA298812	Hs. 98539	ESTs	7.353E−02	3.75	38.25
430320	BE245290	Hs. 239218	uncharacterized hypothalamus protein HCD	5.132E−02	3.75	36.5
441516	F06700	Hs. 7879	interferon-related developmental regulat	7.404E−02	3.73	30.75
430730	T71087	Hs. 44197	hypothetical protein DKFZp564D0462	2.299E−02	3.72	44.25
430446	AF131782	Hs. 241438	Homo sapiens clone 24941 mRNA sequence	5.766E−03	3.72	46.25
414899	AW975433	Hs. 36288	ESTs	5.132E−02	3.69	33
447695	AI420116	Hs. 161269	ESTs	2.299E−02	3.69	30.25
402842			ENSP00000241325*: DJ947L8.1.3 (novel CUB	5.681E−03	3.65	30.5
446001	AI827473	Hs. 346435	ESTs	9.366E−03	3.63	46.25
402836			ENSP00000251163*: Membrane-associated gua	4.164E−02	3.60	57.25
410469	AW749723	Hs. 43586	gb: QV3-BT0511-081299-035-d01 BT0511 Homo	8.705E−02	3.60	37
421471	U90545	Hs. 327179	solute carrier family 17 (sodium phospha	3.476E−02	3.58	110.75
456962	BE272095	Hs. 167791	reticulocalbin 1, EF-hand calcium bindin	6.136E−02	3.57	35.75
400301	X03635	Hs. 1657	estrogen receptor 1	1.485E−02	3.57	66.25
438099	AA777767	Hs. 187562	ESTs	4.200E−02	3.56	37.75
441243	AI767056	Hs. 193002	ESTs	2.299E−02	3.55	53
416401	N80139	Hs. 268916	ESTs	2.299E−02	3.55	49.75
402942			Target Exon	5.681E−03	3.55	35.5
451351	AW058261	Hs. 321435	ESTs, Weakly similar to ALU1_HUMAN ALU S	5.132E−02	3.53	38
457565	BE294029	Hs. 279903	Ras homolog enriched in brain 2	2.299E−02	3.52	35
419287	X91906	Hs. 89872	chloride channel 5 (nephrolithiasis 2, X	9.366E−03	3.52	31.75
430807	S74019	Hs. 247979	pre-B lymphocyte gene 1	2.807E−02	3.50	35.5
400302	N48056		folate hydrolase (prostate-specific memb	3.476E−02	3.48	63.75
404657			C9000088*: gi|6754878|ref|NP_035061.1|nu	1.468E−02	3.44	53.75
445664	AW968638	Hs. 237691	ESTs, Weakly similar to KIAA0601-protein	2.807E−02	3.42	39.5
436336	AJ011378	Hs. 186927	ESTs	4.056E−02	3.42	33.25
409959	BE349470		mucin 6, gastric	9.120E−03	3.40	47.5
458443	AV647010	Hs. 27	glycine dehydrogenase (decarboxylating;	4.200E−02	3.40	47.25
411214	BE046571		gb: hn40g11.x1 NCI_CGAP_RDF2 Homo sapiens	2.299E−02	3.38	39.25
437556	AI223078	Hs. 136776	ESTs	9.243E−03	3.35	36.25
425295	AA431366	Hs. 37251	ESTs	7.404E−02	3.32	50
409440	AI239685	Hs. 12315	hypothetical protein FLJ11608	5.091E−02	3.32	30.75
405543			C2002468*: gi|3334856|emb|CAA11279.1| (AJ	4.970E−02	3.30	35.75
449986	AW864502		gb: PM4-SN0016-120400-004-b12 SN0016 Homo	2.299E−02	3.25	60.75
451790	AA927403	Hs. 3803	reticulon 2	5.132E−02	3.24	41.5
456350	BE246762	Hs. 89499	arachidonate 5-lipoxygenase	5.132E−02	3.22	40.5
436169	AA888311	Hs. 17602	Homo sapiens cDNA FLJ12381 fis, clone MA	2.251E−02	3.22	33.25
421497	BE145334	Hs. 194637	BANP homolog, SMAR1 homolog	5.766E−03	3.22	30
449959	AI076834	Hs. 21160	ESTs	4.200E−02	3.20	35.25
441189	AW450266	Hs. 257276	ESTs	7.353E−02	3.19	31.75
411399	AI144416	Hs. 22248	ESTs	7.404E−02	3.15	31.75
447896	AI436124	Hs. 294069	Homo sapiens cDNA FLJ13384 fis, clone PL	2.299E−02	3.15	62
420728	AA767718	Hs. 93581	hypothetical protein FLJ10512	5.132E−02	3.15	41.25
444959	AV652120	Hs. 213232	ESTs, Weakly similar to 2004399A chromos	1.485E−02	3.15	117
424049	AB014524	Hs. 138380	KIAA0624 protein	5.597E−03	3.13	61.25
444363	AI142827	Hs. 143656	ESTs	8.760E−02	3.12	35.5
437056	AI147061		gb: ok33a11.s1 Soares_NSF_F8_9W_OT_PA_P_S	5.091E−02	3.11	32.75
408931	AA251995	Hs. 334648	poly(A) polymerase alpha	2.299E−02	3.11	60
447135	T58148		gb: yb98g06.s1 Stratagene lung (937210) H	1.468E−02	3.10	34.75
451513	AI800283	Hs. 155787	ESTs	2.780E−02	3.08	31.75
430448	AI633553	Hs. 13303	Homo sapiens cDNA: FLJ21784 fis, clone H	5.010E−02	3.07	31.75
413922	AI535895	Hs. 221024	ESTs	3.476E−02	3.07	56
440700	AW952281	Hs. 296184	guanine nucleotide binding protein (G pr	1.485E−02	3.06	96.25
442049	AA310393	Hs. 190044	ESTs	7.404E−02	3.05	36.25
445159	AI631036	Hs. 196843	ESTs	5.132E−02	3.03	30.5
402781			C1001326*: gi|7292419|gb|AAF47823.1|(AE0	3.444E−02	3.03	32.5
450127	AI698001	Hs. 200664	ESTs	1.833E−02	3.03	35.5
416336	R97949	Hs. 24128	ESTs	7.404E−02	3.02	42.5
428337	AA644508		gb: af75C01.r1 Soares_NhHMPu_S1 Homo sapi	2.275E−02	3.02	32.25
441959	BE536998	Hs. 200360	Homo sapiens cDNA FLJ13027 fis. clone NT	3.476E−02	3.01	34.25
450770	AA019924	Hs. 28803	ESTs	3.476E−02	3.01	52.75
414149	BE313317	Hs. 902	neurofibromin 2 (bilateral acoustic neur	7.404E−02	2.99	47.25
444622	H77824		ESTs	5.681E−03	2.98	51
444909	AI933051	Hs. 192280	ESTs	5.132E−02	2.97	42.75
419662	W87674		gb: zh66a01.r1 Soares_fetal_liver_spleen—	7.166E−03	2.97	36
439435	AI627654	Hs. 174497	ESTs, Weakly similar to S43529 165 K prot	6.091E−02	2.97	36.5
435902	AA701867	Hs. 297726	ESTs	7.404E−02	2.95	70
406526			C19001782*: gi|8922411|ref|NP_060558.1|h	5.766E−03	2.95	51.5
405846			Target Exon	5.132E−02	2.95	39.75
448920	AW408009	Hs. 22580	alkylglycerone phosphate synthase	4.164E−02	2.92	43
422561	AA991499	Hs. 118354	CAT56 protein	5.132E−02	2.92	42.75
440915	AI809240	Hs. 210383	olfactory receptor, family 4, subfamily	1.485E−02	2.92	31.25
449495	AI652833		gb: wb22c11.x1 NCI_CGAP_GC6 Homo sapiens	5.132E−02	2.90	34.75
411426	BE141714		gb: QV0-HT0101-061099-032-c04 HT0101 Homo	4.200E−02	2.90	33
435236	T03890	Hs. 157208	ESTs, Highly similar to ARX MOUSE HOMEOB	7.268E−03	2.88	44.75
405152			Target Exon	7.353E−02	2.88	37.5
457230	T73510	Hs. 209153	angiopoietin-like 3	1.468E−02	2.82	50
455485	AA102287	Hs. 26756	hypothetical protein FLJ20896	5.132E−02	2.82	46.5
452266	AI767250	Hs. 165240	ESTs	3.476E−02	2.81	49
418154	BE165866		nuclear receptor subfamily 1, group I, m	7.404E−02	2.80	65.75
405481			Target Exon	5.132E−02	2.80	46.5
404162			NM_022113*: Homo sapiens kinesin family m	3.476E−02	2.80	40.5
415647	F13458	Hs. 6985	ESTs	7.353E−02	2.80	40
456505	AA504595	Hs. 111418	ESTs	1.168E−02	2.78	52.5
447567	AW474513	Hs. 224397	ESTs, Weakly similar to I38931 Wiskott-A	5.766E−03	2.77	43
422473	U94780	Hs. 117242	meningioma expressed antigen 6 (coiled-c	7.353E−02	2.77	40.25
452830	AW976032	Hs. 288912	hypothetical protein FLJ22604	3.476E−02	2.76	30
428375	T65153	Hs. 260282	ESTs	6.091E−02	2.76	32.5
444618	AV653785	Hs. 173334	ELL-RELATED RNA POLYMERASE II, ELONGATIO	7.268E−03	2.73	30.25
432629	AW860548	Hs. 280658	ESTs	2.807E−02	2.73	55.25
457747	AW975000		gb: EST387105 MAGE resequences, MAGN Homo	9.366E−03	2.71	48
449210	AI635363	Hs. 345517	ESTs	7.404E−02	2.71	30
419711	C02621	Hs. 159282	ESTs	2.251E−02	2.71	32
407609	R43159	Hs. 238432	ESTs	5.132E−02	2.70	47.25
438850	R33727	Hs. 24688	EST	1.468E−02	2.70	37.75
449000	U69560	Hs. 3826	kelch-like protein C3IP1	3.444E−02	2.70	33.5
413359	AA524285	Hs. 154172	ESTs, Moderately similar to BCGF_HUMAN B	7.404E−02	2.67	34.75
402168			NM_022046*: Homo sapiens kallikrein 14 (K	5.132E−02	2.66	65
423665	BE167153	Hs. 24380	ESTs	5.132E−02	2.65	47.75
409872	AW502313		gb: UI-HF-BR0p-ajs-d-08-0-Ul.r1 NIH_MGC_5	7.404E−02	2.65	45.5
419853	AA252006	Hs. 190150	ESTs	7.404E−02	2.65	32.25
409277	T05558	Hs. 156880	ESTs	7.404E−02	2.65	59.75
401114			Target Exon	2.299E−02	2.64	33.25
433847	AA610266		ESTs	2.299E−02	2.64	42.25
412204	AI125507	Hs. 130829	ESTs	5.132E−02	2.63	37
454302	AA306105	Hs. 50785	SEC22, vesicle trafficking protein (S. c	6.136E−02	2.63	33.5
425744	AA362985		gb: EST72769 Ovary II Homo sapiens cDNA 5	3.476E−02	2.61	43
404265			ENSP00000243218*: DJ329L24.3 (member of M	1.485E−02	2.60	48.25
447113	AA741545	Hs. 282832	ESTs, Weakly similar to T24961 hypotheti	3.476E−02	2.60	36.75
418383	AA218986	Hs. 118854	ESTs	5.132E−02	2.60	31.5
448339	AL035920	Hs. 20938	RNA binding motif, single stranded inter	3.476E−02	2.60	33.5
435321	R16814	Hs. 112062	ESTs	1.485E−02	2.59	147.5
451898	T92572	Hs. 142019	ESTs, Weakly similar to 1207289A reverse	3.476E−02	2.59	32.25
436869	NM_014867	Hs. 5333	KIAA0711 gene product	1.168E−02	2.59	48.5
450016	AA249590	Hs. 100748	ESTs, Weakly similar to A28996 proline-r	2.299E−02	2.57	54.25
434421	AI915927	Hs. 34771	ESTs	7.353E−02	2.57	73.25
446783	AW138343	Hs. 141867	ESTs	1.485E−02	2.56	58
418812	AB018256	Hs. 283881	KIAA0713 protein	5.132E−02	2.55	34.5
417157	N49713		gb: yv23f06.s1 Soares fetal liver spleen	8.760E−02	2.54	32.75
400308	AF041410		Target	2.275E−02	2.53	34.5
431082	AA491600		gb: ne80a11.s1 NCI_CGAP_Ew1 Homo sapiens	5.132E−02	2.52	66.75
451850	R14553	Hs. 301663	ESTs	6.136E−02	2.51	31.75
406029			Target Exon	7.404E−02	2.50	46.25
413471	BE142098		gb: CM4-HT0137-220999-017-d11 HT0137 Homo	3.444E−02	2.50	44.5
405014	AF042838		mitogen-activated protein kinase kinase	7.353E−02	2.50	35.25
432634	AI650267	Hs. 196169	ESTs	5.132E−02	2.50	32.75
433187	R53995	Hs. 293381	ESTs, Moderately similar to ALU7_HUMAN A	5.132E−02	2.47	33.5
443832	AI829610	Hs. 23531	ESTs	3.476E−02	2.47	37.5
447371	AA334274	Hs. 18368	DKFZP564B0769 protein	7.404E−02	2.46	44.75
458455	AV648310	Hs. 213488	ESTs	3.444E−02	2.45	58.5
447980	AI703397	Hs. 202355	ESTs	8.705E−02	2.45	33
419511	AA429750	Hs. 75113	general transcription factor IIIA	1.485E−02	2.45	41.25
412510	AI056689	Hs. 133538	ESTs, Weakly similar to ALU1_HUMAN ALU S	5.681E−03	2.45	46.25
416153	R13894		gb: yf62a06.r1 Soares infant brain 1NIB H	1.468E−02	2.44	42.75
458492	AI143655	Hs. 231200	ESTs	1.168E−02	2.43	47.5
425224	AA352856	Hs. 147211	ESTs	7.404E−02	2.40	44.75
413489	BE144228		gb: MR0-HT0165-140200-009-d04 HT0165 Homo	1.168E−02	2.40	36.75
437114	AA836641	Hs. 163085	ESTs	1.485E−02	2.38	53.5
457558	AF083955	Hs. 279852	G protein-coupled receptor	5.132E−02	2.37	45
429886	AL050145	Hs. 225986	Homo sapiens mRNA; cDNA DKFZp586C2020 (f	1.168E−02	2.35	52.25
403171			C2001472*: gi|5809678|gb|AAB41848.2|(U64	3.476E−02	2.35	50.5
406126			ENSP00000246871: PMS6 PROTEIN (HPMS6 PROT	3.476E−02	2.35	47.25
428673	AW601325	Hs. 337757	Homo sapiens mRNA; cDNA DKFZp566M063 (fr	5.132E−02	2.35	37.75
421466	U88063	Hs. 104633	agouti (mouse) related protein	7.404E−02	2.33	37.5
453285	X99894	Hs. 32938	insulin promoter factor 1, homeodomain t	7.404E−02	2.32	36.5
441927	AW850555	Hs. 39925	ESTs, Weakly similar to A46010 X-linked	7.404E−02	2.32	30.75
443368	BE568891	Hs. 199210	ESTs, Moderately similar to bK116F5.2 [H	5.681E−03	2.32	42.25
430517	S80071	Hs. 241597	solute carrier family 6 (neurotransmitte	2.299E−02	2.31	45.5
450734	AI732317	Hs. 299119	ESTs, Moderately similar to 2211404A B21	7.353E−02	2.30	34.5
406466			Target Exon	9.243E−03	2.30	48.75
431025	AA490842	Hs. 105269	ESTs	2.807E−02	2.30	38.5
421573	AI302850	Hs. 262455	ESTs	4.200E−02	2.29	44.75
429031	BE002237	Hs. 239666	Homo sapiens cDNA FLJ13495 fis, clone PL	3.476E−02	2.28	42.25
403545			Target Exon	1.812E−02	2.27	40.5
418063	R38973	Hs. 329841	EST	2.299E−02	2.27	39
412243	W37901	Hs. 278349	ESTs	3.444E−02	2.27	31
447793	AI424924	Hs. 211203	ESTs	3.476E−02	2.26	42.25
402370			Target Exon	1.485E−02	2.25	58.25
404150			Target Exon	7.404E−02	2.25	53.75
431668	AW969610	Hs. 151179	ESTs	5.132E−02	2.25	37.75
442174	AI690080	Hs. 128907	ESTs, Weakly similar to ARIX homeodomain	7.404E−02	2.24	44.75
444758	AL044878	Hs. 11899	3-hydroxy-3-methylglutaryl-Coenzyme A re	5.132E−02	2.24	45
431395	AW752337	Hs. 193666	haspin	1.468E−02	2.24	36
447115	AI815852	Hs. 205865	ESTs, Weakly similar to S02392 alpha-2-m	3.444E−02	2.24	34.75
408847	AW290997	Hs. 30348	ESTs	2.275E−02	2.22	46
420843	H96982	Hs. 42321	ESTs	7.353E−02	2.22	39.25
423732	AF058056	Hs. 132183	solute carrier family 16 (monocarboxylic	7.404E−02	2.21	51.75
447083	AI472124	Hs. 157757	ESTs	5.766E−03	2.21	46.5
425757	AA363171		gb: EST72986 Ovary II Homo sapiens cDNA 5	3.476E−02	2.20	33.25
401941			Target Exon	3.476E−02	2.19	39
421193	D60983	Hs. 5096	ESTs, Weakly similar to I38022 hypotheti	1.450E−02	2.19	42.25
441357	AI240184	Hs. 126819	ESTs	7.404E−02	2.19	33.5
451068	AW294432	Hs. 144252	ESTs	7.404E−02	2.18	32.25
427332	R09418	Hs. 261101	ESTs, Weakly similar to I38022 hypotheti	8.760E−02	2.18	45.5
401929			C17001690: gi|6005701|ref|NP_009099.1|AT	5.091E−02	2.18	96.5
433444	AW975324	Hs. 129816	ESTs	3.476E−02	2.18	94.25
444331	AW193342	Hs. 24144	ESTs	7.353E−02	2.18	43.25
445828	F05802	Hs. 81907	ESTs	1.485E−02	2.17	64.25
452137	AI861840	Hs. 211687	ESTs	5.132E−02	2.17	34.75
409061	AI204994	Hs. 7874	Homo sapiens cDNA: FLJ21435 fis, clone C	2.299E−02	2.16	31
457281	BE253012	Hs. 153400	ESTs, Weakly similar to ALU1_HUMAN ALU S	7.404E−02	2.16	31.25
426129	NM_000348	Hs. 1989	steroid-5-alpha-reductase, alpha polypep	3.444E−02	2.15	40.75
453894	AW937825	Hs. 56847	Homo sapiens cDNA FLJ12874 fis, clone NT	6.136E−02	2.14	54.25
403923			Target Exon	3.444E−02	2.13	49.25
428655	H05769	Hs. 188757	Homo sapiens, clone MGC: 5564, mRNA, comp	2.299E−02	2.13	32.5
454333	AW373209		gb: RC5-BT0506-271199-031-C12 BT0506 Homo	3.444E−02	2.12	44.5
445805	C16975	Hs. 301444	KIAA1673	4.200E−02	2.11	32
446709	R10490	Hs. 156341	ESTs	5.431E−03	2.10	32.25
436505	AJ277841	Hs. 120963	ELG protein	7.404E−02	2.10	41.75
427761	AA412205	Hs. 140996	ESTs	4.929E−02	2.10	31.75
417720	AA205625	Hs. 208067	ESTs	5.766E−03	2.10	63.5
417688	R09170	Hs. 284350	ESTs	1.485E−02	2.10	36.25
434521	NM_002267	Hs. 3886	karyopherin alpha 3 (importin alpha 4)	7.353E−02	2.09	35
444900	AI360120	Hs. 148581	ESTs	5.132E−02	2.06	34.5
444595	AL121094	Hs. 83572	hypothetical protein MGC14433	3.444E−02	2.05	34
406180	AB018249		small inducible cytokine subfamily A (Cy	7.404E−02	2.05	45.25
423378	BE313601	Hs. 164866	hypothetical protein FLJ22558	3.476E−02	2.04	41
427227	AF103803	Hs. 283690	hypothetical protein	6.136E−02	2.03	36.25
438163	AI056258	Hs. 122523	ESTs	6.091E−02	2.02	55.75
429219	AI221480	Hs. 99161	ESTs	5.132E−02	2.02	39.25
438011	BE466173	Hs. 145696	splicing factor (CC1.3)	1.485E−02	2.02	38.25
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of responders over Trimean of non-responders Ratio
R3: Difference of Trimean of responders vs. Trimean of non-responders

[0352]

TABLE 6B
Pkey	CAT Number	Accession
409872	1156673_1	AW502313 AW502681 AW502682
409959	1162663_1	BE349470 BE179199 BE179195 BE179198 BE179204 BE162686 AW513804
411047	1230266_1	AW938479 AW850678 AW814826
411214	1235915_1	BE046571 BE046734 BE046555 BE046651 AW827568
411426	1245515_1	BE141714 AW845993 AW845989
413471	1371778_1	BE142098 BE142092
413489	1373392_1	BE144228 BE144291
416153	1573947_1	R13894 H23037 R56371
417157	1653833_1	N49713 N49819 W03810
418154	17249_1	BE165866 BE165832 AA319621 AA401166 AI811901 H78857 X56199 R93797
		AW896675 AA401072 AW374411 H52942 AW896685 AA348138
		AI399764 AA010244 W90159 N90874 AA339496 AW967136 W38705 AA029093
		AW444647 BE175700 AV651656 AV651847 AA332039
		AV649227 AV649164 AV649491 N87956 AA332262 BE001561 H75493
		BE218742 AA333298 AA095633 AA091968 M78602 T05342 W17094
		AA126501 AW374665 AI452905 AW316900 AI185080 AI202928 AI651843 AA693541
		AI681019 AV658257 AV658133 BE045335 BE089546
		AA300830 AA361376 BE218739 AW207622 AA765340 AW612733 BE348741 AI806054
		AI871563 AA808652 AI500693 AW342032 AA147066
419662	1870052_1	W87674 W87872 W87774
423983	233891_1	AA333261 AA333365 AA552870
425744	255834_1	AA362985 AW963337 T27244
425757	255956_1	AA363171 AW963347 AA371863
428337	289967_1	AA644508 AA479489 AA426174
431082	327710_1	AA491600 AA491645 AI920986
431300	331217_1	AA502346 BE159863
432474	348197_1	AA584042 AW973273 AA548798
433171	360292_1	AA579425 AW969965 AA579102
433847	374914_1	AA610266 AA610273 AA632625 AA812563 AI688018 AI094802 H79160 R99139
434995	397210_1	AW974995 AI821880 AI821932 AI791196 AA659617 AI821137 AA658925
437056	432262_1	AI147061 AA743380 AA765223 AW976398 AI803927
442552	54472_3	R20624 AA809852 AW025682 AW292949 H02596 AA633530 AA846566 AA806021
		AA713679 AI364631 BE350976 AW076131 AW518885
		AW263078 AI417702 AW086132 AI628605 AI769772 H02691 AW591478 H50040 AA227699
		AI885558 AA400937 AI261878 R82844 AW075473
		AI453800 N56889 AI922512 N51071 N51720 N51823 A1654491 W95290 AI272033 AI695006
		AI918702 AI638383 BE552047 AI783684 AI126790
		H01465 BE243273
444622	61286_1	H77824 AA370099 AW956039 H73387 R93651 AV650472
447135	70963_1	T58148 AW516579 AW059603
449495	808345_1	AI652833 AI695904 AW888916
449625	8113_1	NM_014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060
		BE168542 AW296554 AA323193 AA235370 AW779760
		N48674 AI375997 R45432 D59344 AI203107 F07491 R35360 R25094 AI913631 AI498402 T61382
		AI016320 N45526 T61415 AA331486
449986	821463_1	AW864502 AW864369 AI678780
454333	1115507_1	AW373209 AW373205
455358	1284494_1	AW902641 AW902569 AW902654 AW902557 AW902650 AW902644 AW902741
457247	308656_1	AA458605 AW977252 AI261627 AW274550 AI418272 AW665579
		AA731376 AW293861 D80453 AI217860
457747	397222_1	AW975000 AA658945 AA661558
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0353]

TABLE 6C
Pkey	Ref	Strand	Nt_position
400738	7321559	Plus	150214-150446
400864	9798617	Minus	2555-2673, 27827-28000
401114	9966554	Plus	52327-53385
401197	9719705	Plus	176341-176452
401529	7770649	Minus	14577-15668
401593	7230957	Plus	10368-10572, 11293-12356
401757	7239630	Plus	88641-88751
401778	7249133	Minus	136881-137147, 137499-137628,
			137858-138143, 141015-142602
401929	3810670	Minus	3167-3286, 4216-4310
401941	4982556	Plus	112022-112204
402168	7458725	Minus	43245-43397
402370	9558580	Minus	14525-15733
402439	9796503	Minus	108604-108764
402781	7387389	Plus	100409-100666
402836	8745058	Minus	96756-96941
402842	9369121	Minus	76355-76479
402942	9368398	Plus	102152-102386
403171	9838164	Minus	74502-74703
403545	8078400	Plus	25293-25640
403609	8308266	Minus	125974-126320
403686	7387348	Minus	66625-68364
403923	7454203	Minus	1793-2128
404150	7534008	Plus	165811-165943
404162	9926427	Minus	107973-108135
404265	9437317	Minus	50752-50877
404657	9797066	Minus	12444-12548, 17348-17455
405014	6478993	Minus	100709-100845
405152	9965561	Minus	137662-137969
405206	6692345	Plus	17807-18338, 20430-20538
405481	3688109	Plus	5718-5837, 8719-8818
405543	9857582	Minus	104338-104449
405846	7637314	Plus	6623-7188
406029	8312328	Plus	63187-63801
406126	7108191	Minus	46035-46534
406180	7283201	Minus	38923-39107
406299	5686278	Minus	35655-36119
406466	9795550	Plus	115511-115658, 118766-118915,
			121699-121771
406526	7711448	Minus	102742-102944
406528	7711464	Minus	11201-11407, 12589-12733,
			13287-13499
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham I. et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0354] Table 7A lists about 1298 genes up-regulated in Hepatitis C positive liver tissues compared to Hepatitis C negative liver tissues. These genes have potential to be diagnostics and/or prognostic markers for Hepatitis C infected liver tissues. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of Hepatitis C positive liver tissues to the “weighted average” of Hepatitis C negative liver tissues was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the Hepatitis C positive liver tissues was set to the trimean of several different Hepatitis C positive liver tissues. The “weighted average” of the Hepatitis C negative liver tissues was set to the either 10 or the trimean of several different Hepatitis C negative liver tissues, whichever value was greater to eliminate ratios with a denominator of zero or less.

TABLE 7A
Pkey	ExAccn	UniGene	Unigene Title	R1	R2
428227	AA321649	Hs. 2248	small inducible cytokine subfamily B (Cy	1.74E−07	25.27
414004	M737033	Hs. 7155	ESTs, Moderately similar to 2115357A TYK	3.18E−07	24.52
448111	AA053486	Hs. 20315	interferon-induced protein with tetratri	4.93E−07	24.00
417621	AV654694	Hs. 82316	interferon-induced, hepatitis C-associat	2.36E−07	23.13
422746	NM_004484	Hs. 119651	glypican 3	4.03E−06	22.55
426711	AA383471	Hs. 343800	conserved gene amplified in osteosarcoma	1.75E−07	20.97
424090	X99699	Hs. 139262	XIAP associated factor-1	2.78E−05	17.80
433854	AA610649	Hs. 333239	ESTs	2.26E−04	15.90
451652	AA018968	Hs. 133536	ESTs	1.62E−04	15.05
427283	AL119796	Hs. 174185	ectonucleotide pyrophosphatase/phosphodi	4.02E−06	14.90
413670	AB000115	Hs. 75470	hypothetical protein, expressed in osteo	6.13E−07	14.59
418216	AA662240	Hs. 283099	AF15q14 protein	4.93E−07	14.17
425787	AA363867	Hs. 155029	ESTs	7.26E−05	13.57
446094	AK001760	Hs. 13801	KIAA1685 protein	2.95E−05	12.90
450937	R49131	Hs. 26267	ATP-dependant interferon response protei	4.61E−06	12.07
442048	M974603		gb: op34f05.s1 Soares_NFL_T_GBC_S1 Homo s	3.34E−05	11.92
408393	AW015318	Hs. 23165	ESTs	1.31E−05	11.82
415443	T07353	Hs. 7948	ESTs	1.67E−03	11.80
417308	H60720	Hs. 81892	KIAA0101 gene product	2.17E−05	11.70
416206	AW206248	Hs. 111092	hypothetical protein FLJ22332	2.50E−06	11.35
432378	AI493046	Hs. 146133	ESTs	3.52E−06	11.13
430200	BE613337	Hs. 234896	geminin	7.59E−07	11.04
445823	AI478563	Hs. 145519	FKSG87 protein	1.15E−05	11.00
447973	AB011169	Hs. 20141	similar to S. cerevisiae SSM4	4.52E−05	10.97
409153	W03754	Hs. 50813	hypothetical protein FLJ20022	5.70E−07	10.72
451752	AB032997		KIAA1171 protein	1.74E−07	10.54
414052	AW578849	Hs. 283552	ESTs, Weakly similar to unnamed protein	1.77E−06	10.45
409231	AA446644	Hs. 692	GA733-2 antigen; epithelial glycoprotein	1.03E−04	10.30
432094	AI658580	Hs. 61426	Homo sapiens mesenchymal stem cell prote	5.74E−05	10.17
403790			NM_001334*: Homo sapiens cathepsin O (CTS	1.08E−03	9.65
421057	T58283		Homo sapiens cDNA: FLJ22063 fis, clone H	4.57E−03	9.27
428065	AI634046	Hs. 157313	ESTs	5.43E−03	9.22
444665	BE613126	Hs. 47783	B aggressive lymphoma gene	4.58E−06	9.17
435812	AA700439	Hs. 188490	ESTs	5.03E−04	9.13
418143	M283057	Hs. 266957	hypothetical protein FLJ14281	5.30E−04	9.00
435665	AI248952	Hs. 12320	ESTs	1.77E−06	8.85
407644	D16815		nuclear receptor subfamily 1, group D, m	4.31E−04	8.85
421282	AA286914	Hs. 40782	ESTs	4.54E−04	8.67
422546	AB007969	Hs. 301478	KIAA0500 protein	4.00E−05	8.52
409512	AW979187	Hs. 293591	melanoma differentiation associated prot	2.36E−07	8.50
429490	AI971131	Hs. 23889	ESTs, Weakly similar to ALU7 HUMAN ALU S	1.15E−04	8.50
442994	AI026718	Hs. 16954	ESTs	2.43E−03	8.47
416224	NM_002902	Hs. 79088	reticulocalbin 2, EF-hand calcium bindin	3.74E−06	8.45
417933	X02308	Hs. 82962	thymidylate synthetase	2.02E−03	8.35
405102			C15001220*: gi|4469558|gb|AAD21311.1| (AF	1.93E−03	8.20
444314	AI140497		gb: ow76b09.s1 Soares_fetal liver_spleen—	1.38E−03	8.10
426818	AA554827	Hs. 292996	DKFZp434A0131 protein	9.75E−03	8.02
432954	AI076345		ESTs	2.02E−03	7.88
449541	AA730673	Hs. 188634	ESTs	7.22E−04	7.85
410315	AI638871	Hs. 152519	Homo sapiens cDNA: FLJ22524 fis. clone H	1.30E−05	7.80
433586	T85301		gb: yd78d06.s1 Soares fetal liver spleen	3.20E−03	7.80
436995	AI160015	Hs. 125489	ESTs	5.89E−04	7.80
446619	AU076643	Hs. 313	secreted phosphoprotein 1 (osteopontin,	4.00E−03	7.80
407949	W21874	Hs. 247057	ESTs, Weakly similar to 2109260A B cell	1.03E−04	7.72
421904	BE143533	Hs. 109309	hypothetical protein FLJ20035	7.61E−07	7.67
424848	AI263231	Hs. 327090	EST	2.11E−03	7.63
433401	AF039698	Hs. 284217	serologically defined colon cancer antig	1.57E−05	7.55
435571	AF212225	Hs. 283693	mitochondrial ribosomal protein L1	8.63E−05	7.55
419175	AW270037		KIAA0779 protein	1.01E−05	7.50
407930	AA045847	Hs. 188361	Homo sapiens cDNA FLJ12807 fis, clone NT	6.86E−04	7.47
400247			Eos Control	8.61E−03	7.38
449935	AA004798	Hs. 108311	ESTs, Weakly similar to T00351 hypotheti	1.80E−05	7.38
435102	AW899053	Hs. 76917	F-box only protein 8	3.50E−03	7.32
418452	BE379749	Hs. 85201	C-type (calcium dependent, carbohydrate-	4.25E−07	7.32
425053	AF046024	Hs. 154320	ubiquitin-activating enzyme E1C (homolog	2.81E−04	7.30
431183	NM_006855	Hs. 250696	KDEL (Lys-Asp-Glu-Leu) endoplasmic retic	1.10E−02	7.30
446488	AB037782	Hs. 15119	KIAA1361 protein	2.12E−03	7.25
458725	AW970192	Hs. 171942	ras responsive element binding protein 1	1.71E−04	7.25
449718	AA459480	Hs. 23956	hypothetical protein FLJ20502	1.80E−05	7.17
418840	AI821614	Hs. 185831	ESTs	1.63E−02	7.10
408063	BE086548	Hs. 42346	calcineurin-binding protein calsarcin-1	1.71E−04	7.05
436024	AI800041		ESTs	2.81E−04	7.02
402727			NM_025065: Homo sapiens hypothetical prot	1.02E−02	7.00
447574	AF162666	Hs. 18895	tousled-like kinase 1	1.92E−04	6.97
447809	AW207605	Hs. 164230	ESTs, Highly similar to JC7266 3′,5′-cyc	7.31E−06	6.97
421379	Y15221	Hs. 103982	small inducible cytokine subfamily B (Cy	4.93E−07	6.97
424878	H57111	Hs. 221132	ESTs	2.67E−03	6.95
450016	AA249590	Hs. 4747	ESTs, Weakly similar to A28996 proline-r	8.16E−05	6.90
433230	AW136134	Hs. 220277	ESTs	1.45E−04	6.80
437967	BE277414	Hs. 5947	mel transforming oncogene (derived from	6.72E−03	6.80
419586	AI088485	Hs. 144759	ESTs, Weakly similar to I38022 hypotheti	1.54E−06	6.77
422506	R20909	Hs. 300741	sorcin	3.86E−02	6.77
433730	AK002135	Hs. 3542	hypothetical protein FLJ11273	1.08E−03	6.72
445929	AI089660	Hs. 323401	dpy-30-like protein	4.78E−04	6.72
405268			ENSP00000223174*: KIAA0783 PROTEIN.	2.96E−04	6.70
452973	H88409	Hs. 40527	ESTs	5.20E−03	6.70
452744	AI267652	Hs. 246107	Homo sapiens mRNA; cDNA DKFZp434E082 (fr	5.70E−07	6.61
419407	AW410377	Hs. 41502	hypothetical protein FLJ21276	4.25E−05	6.60
443547	AW271273		hypothetical protein FLJ12666	5.23E−06	6.57
416475	T70298		gb: yd26g02.s1 Soares fetal liver spleen	2.32E−03	6.55
441976	AA428403	Hs. 106131	ESTs	2.50E−04	6.55
446493	AK001389	Hs. 15144	hypothetical protein DKFZp564O043	4.54E−04	6.55
408096	BE250162		dihydrofolate reductase	1.39E−02	6.52
434375	BE277910	Hs. 3833	3′-phosphoadenosine 5′-phosphosulfate sy	2.61E−05	6.52
453887	BE564037	Hs. 36237	hypothetical protein	1.61E−04	6.52
419550	D50918	Hs. 90998	KIAA0128 protein; septin 2	1.44E−06	6.50
424941	AA128376	Hs. 153884	ATP binding protein associated with cell	2.25E−04	6.47
416133	NM_001683	Hs. 89512	ATPase, Ca transporting, plasma membrane	5.20E−03	6.45
442993	BE018682	Hs. 166196	ATPase, Class I, type 8B, member 1	4.00E−05	6.40
445525	BE149866	Hs. 14831	Homo sapiens, Similar to zinc finger pro	1.91E−05	6.35
450293	N36754	Hs. 171118	hypothetical protein FLJ00026	2.52E−04	6.34
409052	AW898179	Hs. 50123	zinc finger protein 189	6.72E−03	6.33
442679	R53718		hypothetical protein FLJ10659	8.87E−06	6.27
418476	AA648431	Hs. 37883	hypothetical protein PNAS-131	3.67E−04	6.25
426925	NM_001196	Hs. 315689	Homo sapiens cDNA: FLJ22373 fis, clone H	9.71E−05	6.25
451788	BE242857	Hs. 27021	hypothetical protein FLJ11159	7.26E−05	6.22
414183	AW957446	Hs. 301711	ESTs	1.45E−03	6.17
425073	W39609	Hs. 22003	solute carrier family 6 (neurotransmitte	1.05E−02	6.17
426110	NM_002913	Hs. 166563	replication factor C (activator 1) 1 (14	3.33E−05	6.13
452548	AL050321	Hs. 301532	CRP2 binding protein	3.29E−04	6.08
433745	AF075320	Hs. 28980	hypothetical protein FLJ14540	3.83E−03	6.07
422173	BE385828	Hs. 250619	phorbolin-like protein MDS019	7.58E−07	6.05
451406	AI694320	Hs. 6295	ESTs, Weakly similar to T17248 hypotheti	1.25E−03	6.04
443852	AI679966	Hs. 150603	ESTs	7.94E−03	6.02
445813	Z42023	Hs. 106576	alanine-glyoxylate aminotransferase 2-li	6.52E−04	6.02
413922	AI535895	Hs. 221024	ESTs	4.57E−03	6.00
426458	D83032	Hs. 169984	nuclear protein	8.28E−03	6.00
443035	Z45822	Hs. 8906	Homo sapiens clone 24889 mRNA sequence	1.44E−04	5.97
447164	AF026941	Hs. 17518	vipirin; similar to inflammatory respon	8.74E−07	5.97
431604	AF175265	Hs. 264190	vacuolar protein sorting 35 (yeast homol	8.84E−04	5.95
445943	AW898533	Hs. 181574	ESTs	6.87E−04	5.95
451122	AA015767	Hs. 84522	ESTs	7.62E−03	5.95
411252	AB018549	Hs. 69328	MD-2 protein	2.60E−05	5.92
423598	BE247600	Hs. 155538	ESTs	9.75E−04	5.92
410361	BE391804	Hs. 62661	guanylate binding protein 1, interferon-	1.74E−03	5.88
417228	AL134324	Hs. 7312	ESTs	4.31E−04	5.88
434421	AI915927	Hs. 34771	ESTs	9.75E−04	5.87
424308	AW975531	Hs. 154443	minichromosome maintenance deficient (S.	2.17E−05	5.82
427484	N32859	Hs. 37288	nuclear receptor subfamily 1, group D, m	2.45E−05	5.82
430261	AA305127	Hs. 4147	hypothetical protein HT023	2.42E−03	5.82
443291	AA325633	Hs. 136102	KIAA0853 protein	3.06E−03	5.82
447735	AA775268	Hs. 6127	Homo sapiens cDNA: FLJ23020 fis, clone L	5.86E−04	5.82
419644	AU076951	Hs. 179573	retinoblastoma-binding protein 1	6.08E−05	5.80
456619	AV647917	Hs. 107153	inhibitor of growth family, member 1-lik	7.31E−06	5.80
414812	X72755	Hs. 77367	monokine induced by gamma interferon	1.34E−06	5.78
430556	AW967807	Hs. 13797	ESTs	1.83E−03	5.77
408360	AI806090	Hs. 44344	hypothetical protein FLJ20534	4.24E−05	5.75
418224	AL036057	Hs. 83795	interferon regulatory factor 2	2.38E−04	5.75
418876	AA740616		gb: ny97f11.s1 NCI_CGAP_GCB1 Homo sapiens	5.09E−05	5.75
456236	AF045229	Hs. 82280	regulator of G-protein signalling 10	1.52E−03	5.72
437374	AL359571	Hs. 44054	ninein (GSK3B interacting protein)	6.85E−05	5.71
445529	H14421	Hs. 180513	ATP-binding cassette, sub-family A (ABC1	9.77E−04	5.70
400517			lengsin	2.45E−05	5.67
410577	X91911	Hs. 64639	glioma pathogenesis-related protein	1.76E−06	5.67
434210	AA665612		ESTs	3.27E−06	5.67
438011	BE466173	Hs. 145696	splicing factor (CC1.3)	7.94E−03	5.67
421594	R45689	Hs. 21889	Homo sapiens cDNA FLJ12978 fis, clone NT	3.50E−03	5.65
400133			Eos Control	1.29E−02	5.63
452827	AI571835	Hs. 55468	ESTs	2.61E−05	5.63
448694	AA478756	Hs. 194477	E3 ubiquitin ligase SMURF2	2.26E−04	5.62
408214	AL120445	Hs. 77823	hypothetical protein FLJ21343	2.66E−04	5.60
449609	BE246434	Hs. 289026	guanine nucleotide binding protein (G pr	6.17E−04	5.59
409277	T05558	Hs. 156880	ESTs	6.17E−03	5.57
421650	AA781795	Hs. 122587	ESTs	1.22E−05	5.57
428172	U09367	Hs. 182828	zinc finger protein 136 (clone pHZ-20)	2.32E−03	5.57
433037	NM_014158	Hs. 279938	HSPC067 protein	3.77E−05	5.57
413509	BE145419		gb: IL5-HT0198-291099-009-E01 HT0198 Homo	1.75E−03	5.52
457130	NM_005651	Hs. 183671	tryptophan 2,3-dioxygenase	5.91E−03	5.52
433208	AW002834	Hs. 24095	ESTs	5.39E−02	5.51
410867	X63556	Hs. 750	fibrillin 1 (Marfan syndrome)	1.96E−02	5.50
412802	U41518	Hs. 74602	aquaporin 1 (channel-forming integral pr	5.89E−04	5.50
416309	R84694	Hs. 79194	cAMP responsive element binding protein	6.82E−05	5.50
437730	AW071087	Hs. 239176	insulin-like growth factor 1 receptor	2.54E−03	5.50
420520	AK001978	Hs. 98510	similar to rab11-binding protein	6.16E−03	5.47
422423	AF283777	Hs. 116481	CD72 antigen	5.67E−03	5.47
431586	AW971100	Hs. 293189	ESTs	2.79E−03	5.47
415660	AI909007	Hs. 78563	ubiquitin-conjugating enzyme E2G 1 (homo	1.96E−02	5.45
424243	AI949359	Hs. 143600	ESTs, Highly similar to cis Golgi-locali	9.29E−04	5.45
439008	AF075072	Hs. 167535	ESTs, Weakly similar to ALU1_HUMAN ALU S	2.66E−03	5.45
443441	AW291196	Hs. 92195	ESTs	4.42E−02	5.45
413010	AA393273	Hs. 75133	transcription factor 6-like 1 (mitochond	4.77E−03	5.42
439375	AA689526	Hs. 344249	steroid dehydrogenase homolog	9.70E−05	5.42
405141			zinc finger protein 200	1.69E−02	5.40
429747	M87507	Hs. 2490	caspase 1, apoptosis-related cysteine pr	1.39E−05	5.40
448901	AK001021	Hs. 22505	hypothetical protein FLJ10159	6.40E−06	5.40
450206	AI796450	Hs. 201600	ESTs	2.52E−04	5.38
437175	AW968078	Hs. 87773	protein kinase, cAMP-dependent, catalyti	2.96E−04	5.37
429588	AI080271		ESTs	2.55E−03	5.36
408048	NM_007203	Hs. 42322	A kinase (PRKA) anchor protein 2	1.01E−02	5.35
422553	AI697720	Hs. 171455	ESTs, Weakly similar to T31613 hypotheti	2.31E−05	5.35
448554	NM_016169	Hs. 21431	suppressor of fused	2.80E−04	5.33
420338	AA825595	Hs. 88269	Homo sapiens, clone MGC: 17339, mRNA, com	4.92E−06	5.32
425167	AA351629	Hs. 225567	ESTs	2.22E−03	5.31
449429	AA054224	Hs. 59847	ESTs	1.10E−02	5.30
436562	H71937	Hs. 322904	ESTs, Weakly similar to I38022 hypotheti	4.77E−03	5.29
407347	AA829847		gb: od40d07.s1 NCI_CGAP_GCB1 Homo sapiens	5.08E−05	5.29
433505	AW504027	Hs. 15301	Homo sapiens cDNA FLJ12596 fis, clone NT	1.13E−03	5.27
439301	AA833784	Hs. 252888	ESTs	1.57E−02	5.27
439195	H89360		gb: yw28d08.s1 Morton Fetal Cochlea Homo	3.20E−03	5.27
414737	AI160386	Hs. 125087	ESTs	6.37E−06	5.25
419490	NM_006144	Hs. 90708	granzyme A (granzyme 1, cytotoxic T-lymp	1.29E−02	5.25
439971	W32474	Hs. 301746	RAP2A, member of RAS oncogene family	1.39E−05	5.25
450697	AW152166	Hs. 182113	ESTs	5.43E−03	5.25
432441	AW292425	Hs. 163484	ESTs	2.52E−04	5.22
410511	AA743475	Hs. 285655	ESTs	4.00E−03	5.20
421535	AB002359	Hs. 105478	phosphoribosylformylglycinamidine syntha	1.59E−03	5.20
427699	AW965076	Hs. 180378	hypothetical protein 669	1.14E−02	5.20
437650	AA814338	Hs. 292297	ESTs	7.30E−03	5.20
408405	AK001332	Hs. 44672	hypothetical protein FLJ10470	1.77E−06	5.18
413007	BE046662		gb: hn42f02.x1 NCI_CGAP_RDF2 Homo sapiens	8.00E−04	5.17
449365	AW968261	Hs. 118913	ESTs, Moderately similar to T46371 hypot	1.10E−02	5.17
452327	AK000196	Hs. 29052	hypothetical protein FLJ20189	5.73E−05	5.17
416701	R94977	Hs. 35416	PRO0132 protein	5.20E−03	5.15
447774	BE018118	Hs. 19554	chromosome 1 open reading frame 2	1.10E−02	5.14
437834	AA769294		gb: nz36g03.s1 NCI CGAP_GCB1 Homo sapiens	2.64E−04	5.13
458965	AA010319	Hs. 60389	ESTs	1.38E−03	5.13
421097	AI280112	Hs. 125232	Homo sapiens cDNA FLJ13266 fis, clone OV	3.26E−02	5.10
410337	M83822	Hs. 62354	cell division cycle 4-like	4.31E−04	5.10
422267	AB033044	Hs. 114012	KIAA1218 protein	4.28E−04	5.10
442878	AI868648	Hs. 22315	ESTs	1.92E−03	5.10
451338	AW612322	Hs. 19131	transcription factor Dp-2 (E2F dimerizat	2.66E−04	5.10
407204	R41933	Hs. 140237	ESTs, Weakly similar to ALU1_HUMAN ALU S	2.52E−04	5.07
431049	AA846576	Hs. 103267	hypothetical protein FLJ22548 similar to	8.59E−05	5.07
419522	AI682428	Hs. 157728	ESTs	2.13E−04	5.05
431736	AI912234	Hs. 3297	ribosomal protein S27a	9.76E−04	5.02
433697	AA600357	Hs. 239489	TIA1 cytotoxic granute-associated RNA-bi	1.34E−02	5.02
403738			C4000675*: gi|3426332|gb|AAC32272.1| (AF0	7.30E−06	5.02
453742	AB037744	Hs. 34892	KIAA1323 protein	3.35E−03	5.02
426052	N49068	Hs. 93966	ESTs	2.96E−04	5.00
430268	AK000737	Hs. 237480	hypothetical protein FLJ20730	4.56E−03	5.00
430512	AF182294	Hs. 241578	U6 snRNA-associated Sm-like protein LSm8	1.39E−02	5.00
434658	AI624436	Hs. 310286	ESTs	1.22E−04	5.00
450086	AW016343	Hs. 233301	ESTs	4.98E−03	5.00
432606	NM_002104	Hs. 3066	granzyme K (serine protease, granzyme 3;	8.15E−05	4.99
450916	AA011597	Hs. 177398	ESTs	4.98E−03	4.98
444372	AW377983	Hs. 298140	Homo sapiens cDNA: FLJ22502 fis, clone H	8.13E−05	4.98
439334	AI148976	Hs. 112062	ESTs	9.71E−04	4.98
440043	BE277457	Hs. 30661	hypothetical protein MGC4606	1.52E−03	4.97
424852	AI222779	Hs. 144848	ESTs	1.06E−02	4.95
443884	N20617	Hs. 194397	leptin receptor	2.54E−02	4.95
444670	H58373	Hs332938	hypothetical protein MGC5370	2.96E−04	4.95
409703	NM_006187	Hs. 56009	2′-5′-oligoadenylate synthetase 3 (100 k	1.74E−07	4.94
426793	X89887	Hs. 172350	HIR (histone cell cycle regulation defec	4.18E−03	4.93
407366	AF026942	Hs. 17518	gb: Homo sapiens cig33 mRNA, partial sequ	3.76E−06	4.92
428255	AI627478	Hs. 187670	ESTs	3.51E−03	4.91
415938	BE383507	Hs. 78921	A kinase (PRKA) anchor protein 1	6.44E−05	4.91
403904			ENSP00000251503*: WUGSC	7.31E−03	4.90
408831	AF090114	Hs. 48433	endocrine regulator	1.81E−04	4.90
414646	AA353776	Hs. 901	CD48 antigen (B-cell membrane protein)	7.82E−06	4.90
420151	AA255931	Hs. 186704	ESTs	8.60E−05	4.90
434158	T86534	Hs. 14372	ESTs	2.43E−03	4.90
450447	AF212223	Hs. 25010	hypothetical protein P15-2	3.99E−03	4.90
447769	AW873704	Hs. 320831	Homo sapiens cDNA FLJ14597 fis, clone NT	4.79E−04	4.89
416050	U51903	Hs. 78993	IQ motif containing GTPase activating pr	3.14E−02	4.88
421215	AI868634	Hs. 246358	ESTs, Weakly similar to T32250 hypotheti	3.99E−05	4.87
408761	AA057264	Hs. 238936	ESTs, Weakly similar to (defline not ava	3.48E−04	4.86
449523	NM_000579	Hs. 54443	chemokine (C-C motif) receptor 5	2.78E−05	4.85
423857	N48902	Hs. 133481	Homo sapiens mRNA; cDNA DKFZp564O0862 (f	1.66E−03	4.82
427384	T82854		gb: yd42a09.r1 Soares fetal liver spleen	1.14E−02	4.82
451273	NM_014811	Hs. 26163	KIAA0649 gene product	4.35E−03	4.82
431620	AA126109	Hs. 264981	2′-5′-oligoadenylate synthetase 2 (69-71	1.75E−07	4.82
439223	AW238299	Hs. 250618	UL16 binding protein 2	5.03E−04	4.82
451081	AI078645	Hs. 431	murine leukemia viral (bmi-1) oncogene h	7.30E−03	4.79
407609	R43159	Hs. 238432	ESTs	1.92E−03	4.77
424683	N87519	Hs. 27196	ESTs	2.52E−04	4.77
429966	BE081342	Hs. 283037	HSPC039 protein	6.93E−02	4.77
443998	AI620661	Hs. 296276	ESTs	8.63E−03	4.77
452820	N46161	Hs. 35274	ESTs	5.43E−03	4.77
454075	R43826	Hs. 16313	Kruppel-like zinc finger protein GLIS2	7.30E−03	4.77
429922	Z97630	Hs. 226117	H1 histone family, member 0	3.25E−02	4.77
422541	NM_005131	Hs. 1540	nuclear matrix protein p84	2.66E−03	4.76
449613	N63808	Hs. 34299	ESTs	5.99E−06	4.75
407309	AA526438	Hs. 281680	peroxisomal trans 2-enoyl CoA reductase;	7.68E−05	4.74
431966	AB037903	Hs. 272257	Homo sapiens truncated AKR mRNA for trun	7.62E−03	4.73
410382	AW664971	Hs. 259546	ESTs	7.68E−05	4.72
434926	BE543269	Hs. 50252	mitochondrial ribosomal protein L32	3.29E−04	4.72
414219	W20010	Hs. 75823	ALL1-fused gene from chromosome 1q	8.62E−03	4.71
413048	M93221	Hs. 75182	mannose receptor, C type 1	1.91E−04	4.67
419110	AA234171	Hs. 187626	ESTs	1.71E−04	4.67
429952	AF080158	Hs. 226573	inhibitor of kappa light polypeptide gen	2.52E−04	4.67
450401	AW959281	Hs. 8184	ESTs	1.19E−03	4.67
432600	AI821085		gb: ns95a12.y5 NCI_CGAP_Pr3 Homo sapiens	2.55E−03	4.65
441892	AB028981	Hs. 8021	KIAA1058 protein	1.29E−04	4.65
446207	AW968535	Hs. 14328	hypothetical protein FLJ20071	9.27E−04	4.65
450516	AA902656	Hs. 21943	NIF3 (Ngg1 interacting factor 3. S. pombe	7.19E−04	4.65
419590	AF005043	Hs. 91390	poly (ADP-ribose) glycohydrolase	6.44E−05	4.65
449909	AA004681	Hs. 59432	ESTs	4.77E−03	4.63
409401	AI201895	Hs. 181309	proteasome (prosome, macropain) subunit.	2.12E−03	4.63
441652	BE467811	Hs. 7471	BBP-like protein 1	1.75E−03	4.61
417688	R09170	Hs. 284350	ESTs	4.78E−04	4.61
411605	AW006831		ESTs	8.26E−03	4.60
408108	AI580492	Hs. 42743	hypothetical protein	1.38E−03	4.60
451079	AI827988	Hs. 240728	ESTs, Moderately similar to PC4259 ferri	8.00E−04	4.60
451326	AW296946	Hs. 256078	ESTs	5.57E−04	4.60
453555	N23574	Hs. 123649	ESTs, Moderately similar to ALU7_HUMAN A	6.81E−05	4.60
447541	AK000288	Hs. 18800	hypothetical protein FLJ20281	2.19E−02	4.60
402737			Target Exon	3.66E−04	4.60
454067	AA041455		ESTs	8.00E−04	4.59
408705	AA312135	Hs. 46967	HSPCO34 protein	3.06E−06	4.57
413786	AW613780	Hs. 13500	ESTs	5.69E−07	4.57
424626	AA344308	Hs. 128427	Homo sapiens BAC clone RP11-335J18 from	2.45E−05	4.57
447023	AA356764	Hs. 17109	integral membrane protein 2A	1.92E−04	4.57
449500	AW956345	Hs. 12926	ESTs	5.56E−02	4.56
432572	AI660840	Hs. 191202	ESTs, Weakly similar to ALUE_HUMAN !!!!	1.06E−02	4.55
446927	AW503484	Hs. 16533	myosin phosphatase, target subunit 1	2.78E−03	4.55
452695	AW780199	Hs. 30327	mitogen-activated protein kinase-activat	2.32E−03	4.55
456034	AW450979		gb: UI-H-BI3-ala-a-12-0-UI.s1 NCI_CGAP_Su	3.26E−02	4.55
401091			decay accelerating factor for complement	7.98E−04	4.52
423250	BE061916	Hs 125849	chromosome 8 open reading frame 2	1.89E−02	4.52
451690	AW451469	Hs. 209990	ESTs	1.06E−02	4.52
443119	AA312264	Hs. 7980	hypothetical protein MGC12966	1.91E−04	4.50
410245	C17908	Hs. 194125	ESTs	1.69E−02	4.49
448760	AA313825	Hs. 323583	AD036 protein	8.13E−05	4.48
417954	AI633943	Hs. 26613	ESTs, Weakly similar to no similarities	5.56E−02	4.47
417973	NM_004490	Hs. 83070	growth factor receptor-bound protein 14	2.73E−02	4.47
419743	AW408762	Hs. 5957	Homo sapiens clone 24416 mRNA sequence	4.88E−02	4.47
429276	AF056085	Hs. 198612	G protein-coupled receptor 51	2.80E−04	4.47
432967	AA572949	Hs. 207566	ESTs	7.59E−03	4.47
433226	AW503733	Hs. 9414	KIAA1488 protein	2.67E−03	4.47
445776	NM_001310	Hs. 13313	cAMP responsive element binding protein-	2.83E−02	4.47
426860	U04953	Hs. 172801	isoleucine-tRNA synthetase	1.34E−02	4.47
419943	AA252111	Hs. 15200	ESTs	4.54E−04	4.47
442202	BE272862	Hs. 106534	hypothetical protein FLJ22625	4.30E−04	4.47
432676	AI187366		gb: qf29c01.x1 Soares_testis_NHT Homo sap	1.45E−04	4.46
421181	NM_005574	Hs. 184585	LIM domain only 2 (rhombotin-like 1)	5.91E−03	4.45
428342	AI739168		Homo sapiens cDNA FLJ13458 fis, clone PL	8.15E−05	4.45
434941	AW073202	Hs. 334825	Homo sapiens cDNA FLJ14752 fis, clone NT	7.95E−03	4.45
446839	BE091926	Hs. 16244	mitotic spindle coiled-coil related prot	4.56E−03	4.45
421508	NM_004833	Hs. 105115	absent in melanoma 2	1.53E−04	4.43
438098	AI076370	Hs. 134037	ESTs	1.19E−02	4.42
449001	AI619957		ESTs	6.17E−03	4.42
409461	AA382169	Hs. 54483	N-myc (and STAT) interactor	4.91E−07	4.42
408461	AB037756	Hs. 45207	hypothetical protein KIAA1335	8.26E−03	4.40
413243	AA769266	Hs. 193657	ESTs	1.06E−02	4.40
450747	AI064821	Hs. 318535	ESTs, Highly similar to 1818357A EWS gen	5.92E−02	4.40
451658	AW195351	Hs. 250520	ESTs, Moderately similar to I38022 hypot	1.22E−04	4.38
419951	AI653415	Hs. 195789	ESTs	8.63E−05	4.38
421685	AF189723	Hs. 106778	ATPase, Ca transporting, type 2C, member	8.00E−04	4.38
424960	BE245380	Hs. 153952	5′ nucleotidase (CD73)	1.06E−02	4.38
432435	BE218886	Hs. 282070	ESTs	1.19E−03	4.38
431863	AA188185	Hs. 289043	spindlin	3.55E−05	4.37
408162	AA993833	Hs. 118527	ESTs	6.41E−03	4.35
417363	AW129357	Hs. 329700	ESTs	9.37E−03	4.35
422879	AI241409	Hs. 188092	ESTs	1.59E−03	4.35
438769	AA830684	Hs. 163426	ESTs	2.79E−03	4.35
443084	AI827639	Hs. 125539	ESTs	2.66E−03	4.35
425068	AL048716	Hs. 154387	KIAA0103 gene product	8.08E−02	4.35
445652	AL117473	Hs. 13036	DKFZP727A071 protein	8.40E−04	4.33
431328	AA502999	Hs. 291591	ESTs	2.03E−04	4.30
434666	AF151103	Hs. 112259	T cell receptor gamma locus	7.99E−04	4.30
452939	R35348	Hs. 24970	ESTs, Weakly similar to B34323 GTP-bindi	6.17E−03	4.30
407690	R47799	Hs. 266957	hypothetical protein FLJ14281	3.28E−06	4.27
432610	BE246615	Hs. 278507	histidyl-tRNA synthetase-like	3.35E−03	4.27
434198	AF119849	Hs. 283028	hypothetical protein PRO1598	2.38E−04	4.27
446751	AA766998	Hs. 79126	Human DNA sequence from clone RP11-16L21	4.58E−02	4.27
447887	AA114050	Hs. 19949	caspase 8, apoptosis-related cysteine pr	7.96E−04	4.27
411656	AW855576		gb: CM4-CT0278-221099-027-d01 CT0278 Homo	3.20E−03	4.25
428720	T90468	Hs. 178154	ESTs	1.25E−03	4.25
432195	AJ243669	Hs. 8127	KIAA0144 gene product	6.52E−04	4.25
433847	AA610266	Hs. 3631	ESTs	4.54E−04	4.25
434987	AW975114		ESTs	7.62E−03	4.25
443020	AI350058	Hs. 106129	ESTs	1.39E−02	4.24
440193	AW902312	Hs. 7037	Homo sapiens clone 24923 mRNA sequence	8.57E−02	4.22
440201	AL359588	Hs. 7041	hypothetical protein DKFZp762B226	1.05E−02	4.22
447513	AW955776	Hs. 313500	ESTs, Moderately similar to ALU7_HUMAN A	2.03E−06	4.22
453793	AK002178	Hs. 35225	hypothetical protein FLJ11316	6.72E−03	4.22
434280	BE005398		gb: CM1-BN0116-150400-189-h02 BN0116 Homo	1.59E−03	4.22
414405	AI362533		KIAA0306 protein	6.39E−06	4.21
433437	U20536	Hs. 3280	caspase 6, apoptosis-related cysteine pr	7.81E−06	4.20
402507			Target Exon	5.30E−04	4.20
430569	AF241254	Hs. 178098	angiotensin | converting enzyme (peptidy	2.45E−02	4.20
442061	AA774284	Hs. 285728	abl-interactor 12 (SH3-containing protei	7.58E−04	4.20
414915	NM_002462	Hs. 76391	myxovirus (influenza) resistance 1, homo	2.36E−07	4.19
442045	C05768	Hs. 8078	Homo sapiens clone FBD3 Cri-du-chat crit	1.31E−03	4.18
402964			NM_022095*: Homo sapiens hypothetical C2H	5.59E−04	4.17
452032	BE244005	Hs. 27610	retinoic acid-and interferon-inducible	4.54E−04	4.17
407218	AA095473		ubiquitin-conjugating enzyme E2H (homolo	7.93E−03	4.17
425387	AB037864	Hs. 156051	KIAA1443 protein	3.65E−04	4.17
431122	AI267593	Hs. 250535	Homo sapiens mRNA; cDNA DKFZp434N2412 (f	6.51E−04	4.17
407756	AA116021	Hs. 38260	ubiquitin specific protease 18	3.41E−07	4.17
407992	AW418811		gb: ha21a06.x1 NCI-HD —	3.64E−03	4.16
			CGAP_Kid12 Homo sapien
416647	BE297139	Hs. 79411	replication protein A2 (32 kD)	7.98E−04	4.16
433017	Y15067	Hs. 279914	zinc finger protein 232	3.31E−05	4.15
435513	AW404075	Hs. 42785	DC11 protein	2.63E−02	4.15
447094	X65232	Hs. 17364	zinc finger protein 79 (pT7)	1.19E−03	4.15
450746	D82673	Hs. 278589	general transcription factor II, i	5.23E−06	4.15
432388	X15218	Hs. 2969	v-ski avian sarcoma viral oncogene homol	8.84E−04	4.15
431976	AA719001	Hs. 291065	ESTs	6.86E−05	4.14
453394	AW960474	Hs. 40289	ESTs	103E−04	4.13
418793	AW382987	Hs. 88474	prostaglandin-endoperoxide synthase 1 (p	1.39E−02	4.13
456439	AA251242	Hs. 103238	ESTs	7.94E−03	4.13
406423			C19000229*: gi|6753826|ref|NP_034311.1| f	2.04E−02	4.13
408392	U28831	Hs. 44566	KIAA1641 protein	5.67E−03	4.13
417601	NM_014735	Hs. 82292	KIAA0215 gene product	3.13E−04	4.13
425462	AI491852	Hs. 46783	Homo sapiens cDNA: FLJ22382 fis, clone H	3.74E−02	4.12
440624	AF017987	Hs. 7306	secreted frizzled-related protein 1	1.10E−02	4.11
422040	AA172106	Hs. 110950	Rag C protein	6.53E−04	4.10
416987	D86957	Hs. 80712	KIAA0202 protein	4.37E−03	4.10
418720	AI381687	Hs. 39526	ESTs	5.39E−02	4.10
433556	W56321	Hs. 111460	calcium/calmodulin-dependent protein kin	1.15E−04	4.10
435260	H64245	Hs. 34458	ESTs	3.35E−03	4.09
443601	AI078554	Hs. 42658	ESTs	1.45E−04	4.09
435029	AF167706	Hs. 19280	cysteine-rich motor neuron 1	1.45E−02	4.08
446667	BE161878	Hs224805	ESTs	2.04E−02	4.06
406038			zinc finger protein 200	2.92E−03	4.05
430468	NM_004673	Hs. 241519	angiopoietin-like 1	1.69E−02	4.05
430522	N75750	Hs. 242271	KIAA0471 gene product	4.00E−03	4.05
423732	AF058056	Hs. 132183	solute carrier family 16 (monocarboxylic	2.02E−03	4.05
408548	AA055449	Hs. 63187	ESTs, Weakly similar to ALUC_HUMAN !!!!	3.66E−03	4.02
451593	AF151879	Hs. 26706	CGI-121 protein	1.71E−04	4.02
459297	BE300741	Hs. 125034	hypothetical protein FLJ13340	2.92E−03	4.02
433001	AF217513	Hs. 279905	clone HQ0310 PRO0310p1	3.13E−04	4.02
433233	AB040927	Hs. 301804	KIAA1494 protein	8.27E−03	4.00
445733	BE295568	Hs. 13225	UDP-Gal: betaGlcNAc beta 1,4-galactosylt	3.06E−03	4.00
444985	AI677737	Hs. 28329	hypothetical protein FLJ14005	8.82E−04	3.98
408380	AF123050	Hs. 44532	diubiquitin	1.54E−06	3.98
416999	AW195747	Hs. 21122	hypothetical protein FLJ11830 similar to	5.89E−04	3.97
424238	AA337401	Hs. 137635	ESTs	2.93E−02	3.97
425395	NM_014102	Hs. 156243	PRO1848 protein	9.70E−05	3.97
442485	BE092285	Hs. 29724	hypothetical protein FLJ13187	1.02E−02	3.97
401649			Target Exon	9.28E−04	3.95
426108	AA622037	Hs. 166468	programmed cell death 5	9.92E−02	3.95
441889	AI090455	Hs. 268371	hypothetical protein FLJ20274	3.74E−02	3.95
428467	AK002121	Hs. 184465	hypothetical protein FLJ11259	1.13E−03	3.95
452194	AI694413		Ubiquitin-like protein FAT10??? - diubiq	2.18E−06	3.93
421443	BE550141	Hs. 156148	hypothetical protein FLJ13231	7.59E−04	3.92
427213	AW007211		hypothetical protein FLJ12876	5.21E−03	3.92
449964	AW001741	Hs. 24243	hypothetical protein FLJ10706	2.01E−03	3.92
435970	H75410	Hs. 54452	zinc finger protein, subfamily 1 A, 1 (lk	1.44E−03	3.92
448965	AF092134	Hs. 22679	CGI-24 protein	5.74E−05	3.90
419737	H24185	Hs. 92918	hypothetical protein	1.75E−03	3.90
425210	AA054679	Hs. 155150	ribonuclease P (14 kD)	7.30E−03	3.90
437862	AW978107	Hs. 5884	Homo sapiens mRNA; cDNA DKFZp586C0224 (f	5.67E−03	3.90
400475			NM_031436*: Homo sapiens hypothetical pro	2.91E−03	3.88
433075	NM_002959		sortilin 1	5.75E−02	3.88
428420	AL096858	Hs. 184245	KIAA0929 protein Msx2 interacting nuclea	5.26E−06	3.86
436139	AA765786	Hs. 120936	ESTs	8.16E−05	3.86
449509	AA001615	Hs. 84561	ESTs	4.13E−02	3.85
452642	AW474296	Hs. 29667	ESTs	1.24E−02	3.85
456107	AA160000	Hs. 137396	ESTs, Weakly similar to JC5238 galactosy	6.15E−03	3.85
457584	AA147979	Hs. 285005	mitochondrial import receptor Tom22	3.13E−04	3.84
414658	X58528	Hs. 76781	ATP-binding cassette, sub-family D (ALD)	4.18E−03	3.84
452866	R26969	Hs. 268016	Homo sapiens cDNA: FLJ21243 fis, clone C	1.38E−03	3.84
412651	AA115333	Hs. 107968	ESTs	4.02E−06	3.84
403575			Target Exon	1.44E−03	3.82
418304	AA215702		gb: zr97g10.r1 NCI_CGAP_GCB1 Homo sapiens	1.59E−03	3.82
435354	AA678267	Hs. 117115	ESTs	4.42E−02	3.82
411400	AA311919	Hs. 69851	nucleolar protein family A, member 1 (H/	3.12E−04	3.82
408618	AK000637	Hs. 46624	HSPC043 protein	1.63E−02	3.81
419135	R61448	Hs. 106728	ESTs, Weakly similar to KIAA1353 protein	2.16E−05	3.80
421965	AA301100	Hs. 346482	gb: EST14128 Testis tumor Homo sapiens cD	3.33E−05	3.79
419908	AW971327	Hs. 293315	ESTs	1.13E−03	3.79
438021	AV653790		WW domain-containing protein 1	9.79E−04	3.78
423450	AJ290445	Hs. 128759	KIAA0524 protein	2.81E−04	3.77
432689	AB018320		Arg/Abl-interacting protein ArgBP2	1.51E−02	3.77
434526	AW085147	Hs. 152779	ESTs	8.24E−03	3.77
436385	BE551618	Hs. 144097	ESTs	5.39E−02	3.77
424003	BE274717	Hs. 137506	Homo sapiens, clone IMAGE: 3605104, mRNA,	1.69E−02	3.75
432409	AA806538	Hs. 130732	KIAA1575 protein	5.93E−02	3.75
432873	AW837268	Hs. 279639	Homo sapiens mRNA; cDNA DKFZp586M2022 (f	1.14E−02	3.74
401016			ENSP00000227126: NAALADASE II PROTEIN.	2.92E−03	3.72
425397	J04088	Hs. 156346	topoisomerase (DNA) II alpha (170 kD)	3.37E−02	3.72
426310	NM_000909	Hs. 169266	neuropeptide Y receptor Y1	6.17E−03	3.72
430016	NM_004736	Hs. 227656	xenotropic and polytropic retrovirus rec	2.93E−02	3.72
434733	AI334367	Hs. 159337	ESTs	4.78E−04	3.72
447892	AI435848	Hs. 172978	ESTs	2.63E−02	3.72
453753	BE252983	Hs. 35086	ubiquitin specific protease 1	4.56E−02	3.72
410099	AA081630		KIAA0036 gene product	7.84E−02	3.72
421205	AL137540	Hs. 102541	netrin 4	6.12E−02	3.71
437629	AW574774	Hs. 121692	ESTs	7.98E−04	3.71
446506	AI123118	Hs. 15159	chemokine-like factor, alternatively spl	1.16E−06	3.71
405689			NM_018850*: Homo sapiens ATP-binding cass	8.40E−04	3.71
427399	NM_014883	Hs. 177664	KIAA0914 gene product	4.54E−04	3.70
417848	AA206581	Hs. 116586	ESTs, Weakly similar to JC5314 CDC28/cdc	1.75E−03	3.70
419511	AA429750	Hs. 75113	general transcription factor IIIA	5.20E−03	3.70
425423	NM_005897	Hs. 157180	intracisternal A particle-promoted polyp	1.44E−03	3.70
433891	AA613792		gb: no97h03.s1 NCI_CGAP_Pr2 Homo sapiens	2.19E−02	3.70
434924	AA443164	Hs. 23259	hypothetical protein FLJ13433	4.01E−05	3.70
442085	AA975688	Hs. 159955	ESTs	4.00E−03	3.70
444363	AI142827	Hs. 143656	ESTs	4.29E−04	3.70
423954	AW753164	Hs. 288604	KIAA1632 protein	2.11E−03	3.69
423494	AW504365	Hs. 24143	Wiskott-Aldrich syndrome protein interac	2.54E−03	3.67
429680	AL035754	Hs. 2474	toll-like receptor 1	1.62E−04	3.67
429686	AI871613	Hs. 28538	Homo sapiens cDNA: FLJ21086 fis, clone C	1.75E−02	3.67
440865	AI281525	Hs. 130180	ESTs	2.43E−03	3.67
444508	AI554691	Hs. 334583	ring finger protein 23	1.02E−03	3.67
427581	NM_014788	Hs. 179703	KIAA0129 gene product	4.92E−07	3.67
438459	T49300	Hs. 35304	Homo sapiens cDNA FLJ13655 fis, clone PL	2.38E−04	3.67
442160	AI337127	Hs. 156325	ESTs	4.00E−06	3.67
448071	BE621584	Hs. 6983	Homo sapiens cDNA: FLJ22646 fis, clone H	1.62E−04	3.65
425757	AA363171		gb: EST72986 Ovary II Homo sapiens cDNA 5	1.13E−03	3.65
431560	BE244135	Hs. 260238	hypothetical protein FLJ10842	5.19E−03	3.65
444969	AI203334	Hs. 160628	ESTs	7.93E−03	3.65
443562	AF118838	Hs. 9599	solute carrier family 25, member 13 (cit	2.04E−02	3.64
435511	AA683336	Hs. 189046	ESTs	1.89E−02	3.64
436503	AJ277750	Hs. 183924	ubiquitin associated and SH3 domain cont	5.67E−03	3.63
417148	AA359896	Hs. 293885	hypothetical protein FLJ14902	6.31E−02	3.63
421114	AW975051	Hs. 293156	ESTs, Weakly similar to 178885 serine/th	2.73E−02	3.63
443373	AI792868	Hs. 135365	ESTs	1.06E−02	3.63
449720	AA311152	Hs. 288708	hypothetical protein FLJ21562	3.99E−05	3.63
451938	AI354355	Hs. 16697	down-regulator of transcription 1, TBP-b	1.38E−03	3.63
457231	AI472022	Hs. 301959	proline synthetase co-transcribed (bacte	1.02E−02	3.63
425332	AA633306	Hs. 127279	ESTs	9.28E−04	3.61
436860	H12751	Hs. 5327	PRO1914 protein	4.08E−04	3.60
400281			Eos Control	2.96E−05	3.60
407946	AA226495	Hs. 154292	ESTs	5.83E−04	3.60
418699	BE539639	Hs. 173030	ESTs, Weakly similar to ALU8_HUMAN ALU S	1.10E−02	3.60
422303	AW410382	Hs. 27556	hypothetical protein FLJ22405	6.32E−02	3.60
425345	AU077297	Hs. 155894	protein tyrosine phosphatase, non-recept	6.44E−03	3.60
425692	D90041	Hs. 155956	N-acetyltransferase 1 (arylamine N-acety	7.67E−05	3.60
428250	AW809208	Hs. 183297	DKFZP566F2124 protein	1.13E−03	3.60
443968	AA287702	Hs. 10031	KIAA0955 protein	1.51E−02	3.60
447433	AA651869	Hs. 5320	hypothetical protein	1.44E−02	3.60
456760	AW961251	Hs. 127828	guanine nucleotide binding protein (G pr	1.31E−03	3.60
430293	AI416988	Hs. 238272	inositol 1,4,5-triphosphate receptor, ty	2.14E−04	3.59
427051	BE178110	Hs. 173374	Homo sapiens cDNA FLJ10500 fis, clone NT	3.49E−02	3.58
408438	AB011180	Hs. 100960	KIAA0608 protein	6.17E−03	3.57
413645	AA130992		gb: zo15e02.s1 Stratagene colon (937204)	1.63E−02	3.57
424881	AL119690	Hs. 153618	HCGVIII-1 protein	6.17E−03	3.57
427471	AA403131	Hs. 266782	KIAA1826 protein	4.37E−03	3.57
430024	AI808780	Hs. 227730	integrin, alpha 6	2.02E−04	3.57
447941	AW181928	Hs. 249946	ESTs	9.64E−02	3.57
418822	Z43371	Hs. 7012	ESTs	1.19E−03	3.56
409342	AU077058	Hs. 54089	BRCA1 associated RING domain 1	6.72E−03	3.55
410054	AL120050	Hs. 58220	Homo sapiens cDNA: FLJ23005 fis, clone L	8.27E−03	3.55
419440	AB020689	Hs. 90419	KIAA0882 protein	7.61E−04	3.55
423886	AA332098		gb: EST36256 Embryo, 8 week I Homo sapien	2.21E−03	3.55
437133	AB018319	Hs. 5460	KIAA0776 protein	4.14E−02	3.55
445718	H79791	Hs. 15227	ESTs	2.78E−05	3.55
408731	R85652		Homo sapiens mRNA; cDNA DKFZp434F1928 (f	1.29E−04	3.55
409038	T97490	Hs. 50002	small inducible cytokine subfamily A (Cy	7.24E−04	3.53
403809			NM_024743*: Homo sapiens hypothetical pro	3.37E−02	3.52
417301	AI478158	Hs. 164478	hypothetical protein FLJ21939 similar to	2.55E−03	3.52
421684	BE281591	Hs. 106768	hypothetical protein FLJ10511	4.14E−02	3.52
432834	F06459	Hs. 289113	cytochrome b5 reductase 1 (B5R.1)	1.69E−02	3.52
439763	AA845366	Hs. 184075	ESTs, Weakly similar to ALU1_HUMAN ALU S	4.36E−03	3.52
445240	AI217385	Hs. 147574	ESTs	2.45E−02	3.52
444545	AW995346	Hs. 146910	ESTs	2.63E−02	3.52
420789	AI670057	Hs. 199882	ESTs	4.73E−02	3.52
421662	NM_014141	Hs. 106552	cell recognition molecule Caspr2	6.19E−04	3.51
426181	AA371422	Hs. 334371	hypothetical protein MGC13096	1.59E−03	3.51
421951	BE327432	Hs. 109804	H1 histone family, member X	1.83E−03	3.50
426780	BE242284	Hs. 172199	adenylate cyclase 7	1.67E−03	3.50
429301	AA449416	Hs. 31395	ESTs	4.76E−03	3.50
430750	AI650360	Hs. 100256	ESTs	5.89E−03	3.50
443126	AI033503		gb: ox06d11.s1 Soares_fetal_liver_spleen—	1.39E−02	3.50
450253	AL133047	Hs. 24715	Homo sapiens mRNA; cDNA DKFZp434D0215 (f	2.79E−03	3.50
442739	NM_007274	Hs. 8679	cytosolic acyl coenzyme A thioester hydr	1.31E−03	3.49
430478	NM_014349	Hs. 241535	apolipoprotein L, 3	1.74E−07	3.49
408784	AW971350	Hs. 63386	ESTs	1.90E−05	3.47
417562	AW888754	Hs. 134126	crystallin, gamma S	2.92E−03	3.47
437664	AW977714	Hs. 211610	ESTs, Moderately similar to ALU1_HUMAN A	3.35E−03	3.47
448219	AA228092		KIAA1681 protein	1.29E−02	3.47
403671			C4001270*: gi|7509005|pir||T26190 hypothe	8.28E−03	3.47
427008	Z45258	Hs. 286013	short coiled-coil protein	1.37E−04	3.46
409005	AW299806	Hs. 297256	ESTs	2.67E−03	3.46
446162	AI631319	Hs. 63841	hypothetical protein DKFZp434E2318	1.19E−02	3.45
453686	AL110326	Hs. 304679	ESTs, Moderately similar to Z195_HUMAN Z	3.66E−04	3.45
441297	AW403084	Hs. 7766	ubiquitin-conjugating enzyme E2E 1 (homo	8.85E−04	3.44
430457	AI436216	Hs. 191715	ESTs, Weakly similar to ZN91_HUMAN ZINC	3.66E−03	3.43
413392	AW021404	Hs. 13021	ESTs	1.29E−02	3.42
416980	AA381133	Hs. 80684	high-mobility group (nonhistone chromoso	1.45E−02	3.42
417244	T57053	Hs. 10136	ESTs	4.18E−03	3.42
422343	AI628633	Hs. 346823	gb: ty77d05.x1 NCI_CGAP_Kid11 Homo sapien	1.06E−02	3.42
426494	AL119528	Hs. 170098	KIAA0372 gene product	1.44E−02	3.42
427722	AK000123	Hs. 180479	hypothetical protein FLJ20116	4.28E−02	3.42
441466	AW673081	Hs. 54828	ESTs	1.14E−02	3.42
450850	AA648886	Hs. 151999	ESTs	9.18E−05	3.42
418259	AA215404		ESTs	3.54E−05	3.40
423032	AI684746	Hs. 119274	RAS p21 protein activator (GTPase activa	1.25E−03	3.40
452167	N75238	Hs. 13075	Homo sapiens cDNA: FLJ23013 fis, clone L	4.18E−03	3.40
415023	AA932146		Homo sapiens clone TCCCIA00164 mRNA sequ	6.18E−04	3.40
424088	AL049942	Hs. 139240	DKFZP564F1422 protein	8.79E−04	3.40
419438	AA406400	Hs. 12482	glyceronephosphate O-acyltransferase	7.62E−03	3.39
441077	AI241273	Hs. 15312	ESTs	3.07E−06	3.38
420664	AI681270	Hs. 99824	BCE-1 protein	4.09E−04	3.38
426979	AF161472	Hs. 173074	DKFZP564O1863 protein	7.37E−02	3.38
437410	AW023340	Hs. 14880	ESTs	4.36E−03	3.38
444430	AI611153	Hs. 6093	Homo sapiens cDNA: FLJ22783 fis, clone K	4.89E−02	3.38
417678	X06560	Hs. 82396	2′,5′-oligoadenylate synthetase 1 (40-46	4.94E−07	3.37
410243	D83402	Hs. 302085	prostaglandin I2 (prostacyclin) synthase	4.88E−02	3.35
412634	U55984		heat shock 90 kD protein 1, alpha	2.51E−04	3.35
419970	AW612022		ESTs	8.62E−03	3.35
439717	W94472	Hs. 59529	ESTs, Moderately similar to ALU1_HUMAN A	1.29E−02	3.35
444013	T08531	Hs. 44404	Homo sapiens PRO1488 mRNA, complete cds	5.91E−03	3.35
444454	BE018316	Hs. 11183	sorting nexin 2	1.37E−04	3.35
439776	AL360140	Hs. 176005	Homo sapiens mRNA full length insert cDN	4.36E−03	3.34
408989	AW361666	Hs. 49500	KIAA0746 protein	3.99E−05	3.34
452187	AA400200	Hs. 19131	transcription factor Dp-2 (E2F dimerizat	7.94E−03	3.33
457701	AW855466	Hs. 271866	ESTs, Weakly similar to ALU1_HUMAN ALU S	7.23E−04	3.33
418318	U47732	Hs. 84072	transmembrane 4 superfamily member 3	4.54E−04	3.33
438922	R71288	Hs. 259664	ESTs	6.44E−03	3.33
430008	AW085625	Hs. 186838	ESTs, Weakly similar to Z295_HUMAN ZINC	1.06E−02	3.33
438543	AA810141	Hs. 192182	ESTs	2.16E−05	3.32
447188	H65423	Hs. 17631	hypothetical protein DKFZp434E2135	1.29E−02	3.32
454064	AI130731	Hs. 57967	ESTs	1.10E−02	3.32
433198	AA992841	Hs. 27263	KIAA1458 protein	3.04E−02	3.32
402041			C15001201*: gi|6841178|gb|AAF28942.1|AF16	3.19E−03	3.31
441028	AI333660	Hs. 17558	Homo sapiens cDNA FLJ14446 fis, clone HE	9.30E−04	3.31
433483	AI926520	Hs. 31016	putative DNA binding protein	1.45E−02	3.31
419126	AI810144	Hs. 135276	ESTs	6.17E−03	3.30
417052	NM_000712	Hs. 81029	biliverdin reductase A	1.91E−05	3.30
433907	AW296107	Hs. 152686	ESTs	4.37E−03	3.29
433364	AI075407	Hs. 296083	ESTs, Moderately similar to I54374 gene	1.75E−07	3.29
449188	AW072939	Hs. 347187	myotubularin related protein 1	8.61E−05	3.29
442831	AI798959	Hs. 131686	ESTs	2.81E−04	3.28
420985	X94703		RAB28, member RAS oncogene family	1.02E−03	3.28
446111	W56338	Hs. 13880	CGI-143 protein	1.24E−02	3.28
456984	AB002349		Ral guanine nucleotide exchange factor R	6.43E−03	3.28
418945	BE246762	Hs. 89499	arachidonate 5-lipoxygenase	3.66E−04	3.27
427675	AW138190	Hs. 180248	zinc finger protein 124 (HZF-16)	6.43E−05	3.27
444030	AW021254	Hs. 135055	ESTs	1.75E−02	3.27
423828	AA331536		gb: EST35377 Embryo, 8 week I Homo sapien	4.17E−03	3.26
426030	BE243933	Hs. 108642	zinc finger protein 22 (KOX 15)	5.21E−02	3.26
411777	BE067552		gb: MR4-BT0358-020200-002-g10 BT0358 Homo	1.59E−03	3.26
413568	AA130381	Hs. 180257	ESTs	2.16E−05	3.25
421828	AW891965		histone deacetylase 3	1.01E−02	3.25
439389	AA318940	Hs. 56004	ESTs	4.72E−02	3.25
442297	NM_006202	Hs. 89901	phosphodiesterase 4A, cAMP-specific (dun	3.50E−03	3.25
451099	R52795	Hs. 25954	interleukin 13 receptor, alpha 2	1.76E−02	3.25
424915	R42755	Hs. 23096	ESTs	2.92E−03	3.24
452279	AA286844		hypothetical protein FLJ13164	9.93E−02	3.24
418791	AA935633	Hs. 194628	ESTs	5.92E−03	3.24
453822	NM_014116	Hs. 35416	PRO0132 protein	7.15E−02	3.24
456119	AA161411	Hs. 58668	chromosome 21 open reading frame 57	1.44E−03	3.23
439708	AI761369	Hs. 59584	hypothetical protein FLJ21144	1.03E−04	3.23
400189			Eos Control	1.34E−02	3.22
430929	AA489166	Hs. 156933	ESTs	4.54E−04	3.22
453128	AW026516	Hs. 31791	acylphosphatase 2, muscle type	350E−03	3.22
413129	AF292100	Hs. 104613	RP42 homolog	3.67E−04	3.22
435126	AI393666	Hs. 42315	p10-binding protein	5.04E−02	3.22
417831	H16423	Hs. 82685	CD47 antigen (Rh-related antigen, integr	9.76E−04	3.21
449209	BE616830	Hs. 294145	ESTs	3.05E−03	3.20
414821	M63835	Hs. 77424	Fc fragment of IgG, high affinity la, re	3.03E−02	3.20
442961	BE614474		F-box only protein 22	5.10E−05	3.20
436854	AA749167	Hs. 173911	ESTs	2.04E−02	3.20
450222	U75308	Hs. 24644	TATA box binding protein (TBP)-associate	2.32E−03	3.20
426312	AF026939	Hs. 181874	interferon-induced protein with tetratri	3.66E−07	3.18
418757	AI864193	Hs. 169728	hypothetical protein FLJ13150	4.99E−03	3.18
422150	AI867118		calpastatin	2.83E−02	3.18
403478			NM_022342: Homo sapiens kinesin protein 9	6.11E−02	3.17
414650	AA150435	Hs. 8248	ESTs	5.04E−02	3.17
431188	W05656	Hs. 169755	ESTs	1.19E−02	3.17
436262	AA707425		gb: ag83f05.r1 Stratagene hNT neuron (937	6.44E−03	3.17
439680	AW245741	Hs. 58461	ESTs, Weakly similar to A35659 krueppel-	3.50E−03	3.17
447371	AA334274	Hs. 18368	DKFZP564B0769 protein	1.51E−02	3.17
448914	AI927656	Hs. 196459	ESTs	9.91E−02	3.17
448481	W15284	Hs. 74832	ESTs	3.35E−03	3.17
414449	AA557660	Hs. 76152	decorin	3.49E−02	3.15
418721	NM_002731	Hs. 87773	protein kinase, cAMP-dependent, catalyti	1.71E−04	3.15
407821	AA346172	Hs. 195614	ESTs	2.65E−04	3.15
410390	AA876905	Hs. 125286	ESTs	6.72E−03	3.15
412977	AA125910	Hs. 191461	ESTs	6.51E−04	3.15
426506	AW935187	Hs. 170162	KIAA1357 protein	2.81E−04	3.15
436169	AA888311	Hs. 17602	Homo sapiens cDNA FLJ 12381 fis, clone MA	7.20E−04	3.15
441879	AI521936	Hs. 107149	novel protein similar to archaeal, yeast	1.29E−04	3.15
444342	NM_014398	Hs. 10887	similar to lysosome-associated membrane	3.41E−07	3.15
448919	AI590605	Hs. 191036	ESTs	3.04E−03	3.15
408683	R58665	Hs. 46847	TRAF and TNF receptor-associated protein	2.03E−06	3.15
436535	AW295687	Hs. 254420	ESTs	1.29E−04	3.14
411060	NM_006074	Hs. 318501	Homo sapiens mRNA full length insert cDN	2.74E−07	3.14
419195	AW291165	Hs. 25447	ESTs	4.57E−03	3.14
434821	AA159111	Hs. 284281	Human putative ribosomal protein S1 mRNA	1.36E−04	3.14
450056	BE047394	Hs. 8208	ESTs, Weakly similar to S71512 hypotheti	2.66E−04	3.13
429286	AA449239	Hs. 154855	ESTs	1.13E−03	3.13
418027	AB037807	Hs. 83293	hypothetical protein	6.08E−05	3.13
450374	AA397540	Hs. 60293	Homo sapiens clone 122482 unknown mRNA	5.05E−02	3.13
426381	T61692	Hs. 269340	ESTs	7.37E−02	3.12
413838	AV661185	Hs. 75574	mitochondrial ribosomal protein L19	2.43E−03	3.12
408931	AA251995	Hs. 334648	poly(A) polymerase alpha	4.97E−03	3.12
430532	D61216	Hs. 18672	ESTs	4.77E−03	3.12
446177	AK001902	Hs. 14202	hypothetical protein FLJ11040	1.80E−04	3.11
407436	AF211977		gb: Homo sapiens LENG10 mRNA, partial seq	1.63E−02	3.11
418733	AA227714		KIAA0129 gene product	2.03E−06	3.11
403027			C21000364*: gi|8394509|ref|NP_058778.1|u	8.80E−04	3.11
419257	X53461	Hs. 89781	upstream binding transcription factor, R	1.15E−04	3.11
410425	BE278367	Hs. 63510	KIAA0141 gene product	1.63E−02	3.10
426647	AA243464	Hs. 294101	pre-B-cell leukemia transcription factor	1.92E−03	3.10
434629	AA789081	Hs. 4029	glioma-amplified sequence-41	2.12E−03	3.10
418182	AW016405	Hs. 16648	ESTs	1.67E−03	3.09
449832	AA694264	Hs. 60049	ESTs	2.73E−02	3.09
407813	AL120247	Hs. 40109	KIAA0872 protein	2.26E−04	3.08
452664	AA398859	Hs. 18397	hypothetical protein FLJ23221	3.07E−06	3.08
410851	AW612147	Hs. 32058	Homo sapiens C1orf19 mRNA, partial cds	2.79E−03	3.07
448362	AA641767	Hs. 21015	hypothetical protein DKFZp564L0864 simil	4.14E−02	3.07
449656	AA002008	Hs. 188633	ESTs	2.02E−03	3.07
416039	AA376989	Hs. 78989	alcohol dehydrogenase 5 (class III), chi	1.03E−03	3.07
418729	AB028449	Hs. 87889	helicase-moi	2.52E−04	3.07
431629	AU077025	Hs. 265827	interferon, alpha-inducible protein (clo	2.74E−07	3.06
437151	AA745618		BANP homolog, SMAR1 homolog	5.93E−02	3.06
414948	C15240	Hs. 182155	ESTs	8.63E−05	3.05
419465	AW500239	Hs. 21187	Homo sapiens cDNA: FLJ23068 fis, clone L	2.63E−02	3.05
432680	T47364	Hs. 278613	interferon, alpha-inducible protein 27	1.75E−07	3.05
418627	AL079835	Hs. 86858	ribosomal protein S6 kinase, 70 kD, polyp	1.02E−03	3.04
408753	AI337192	Hs. 47438	SH3 domain binding glutamic acid-rich pr	1.75E−02	3.04
421654	AW163267	Hs. 106469	suppressor of var1 (S. cerevisiae) 3-like	6.12E−02	3.03
421272	AA704157		ESTs	7.22E−04	3.03
420174	AI824144	Hs. 199749	ESTs	4.79E−05	3.03
439024	R96696	Hs. 35598	ESTs	3.61E−02	3.03
407705	AB023139	Hs. 37892	KIAA0922 protein	4.29E−04	3.02
409977	AW805510	Hs. 97056	hypothetical protein FLJ21634	5.58E−04	3.02
411960	R77776	Hs. 18103	ESTs	1.05E−02	3.02
437086	AW291411	Hs. 192531	ESTs, Weakly similar to S00754 zinc fing	5.20E−03	3.02
442071	BE048433	Hs. 276043	ESTs	2.02E−03	3.02
448030	N30714	Hs. 325960	membrane-spanning 4-domains, subfamily A	4.87E−02	3.02
430068	AA464964		gb: zx80f10.s1 Soares ovary tumor NbHOT H	9.30E−04	3.02
436090	AI640635	Hs. 332879	EST	2.04E−02	3.01
408047	AW205461	Hs. 243612	ESTs	1.81E−04	3.00
412288	NM_003005	Hs. 73800	selectin P (granule membrane protein 140	5.91E−03	3.00
432474	AA584042		gb: nn65e09.s1 NCI_CGAP_Lar1 Homo sapiens	6.72E−02	3.00
446851	AW007332		Homo sapiens cDNA: FLJ22063 fis, clone H	2.43E−03	3.00
451171	AA248829	Hs. 112921	gb: jj6059.seq.F Human fetal heart, Lambd	7.98E−04	3.00
452429	AK000149	Hs. 29493	hypothetical protein FLJ20142	8.96E−03	3.00
413278	BE563085	Hs. 833	interferon-stimulated protein, 15 kDa	1.75E−07	2.98
426221	AB007881		KIAA0421 protein	2.55E−03	2.98
411190	AA306342	Hs. 69171	protein kinase C-like 2	3.87E−02	2.97
444437	AI377961	Hs. 44041	ESTs	8.62E−03	2.97
451572	AA018556	Hs. 268691	ESTs, Moderately similar to ALU2_HUMAN A	1.09E−04	2.97
452420	BE564871	Hs. 29463	centrin, EF-hand protein, 3 (CDC31 yeast	6.84E−05	2.97
412675	AA460716	Hs. 9788	hypothetical protein MGC10924 similar to	2.04E−02	2.97
446215	AW821329	Hs. 14368	SH3 domain binding glutamic acid-rich pr	6.45E−03	2.96
442287	AW952703	Hs. 8182	synaptic nuclei expressed gene 1b	1.67E−03	2.96
439658	AA332057	Hs. 6639	hypothetical protein MGC15440	5.03E−04	2.96
400471			Target Exon	6.12E−02	2.95
431266	AW149321	Hs. 105411	ESTs	2.12E−03	2.95
404433			C8000067*: gi|10432400|emb|CAC10290.1|(A	1.75E−02	2.95
435852	H72303	Hs. 36011	ESTs	4.18E−03	2.95
437275	AW976035	Hs. 292396	ESTs, Weakly similar to A47582 B-cell gr	4.18E−03	2.95
439601	AB029032	Hs. 6606	KIAA1109 protein	1.50E−02	2.95
458455	AV648310	Hs. 213488	ESTs	8.62E−03	2.95
411943	BE502436	Hs. 7962	ESTs, Weakly similar to S44608 C02F5.6 p	7.94E−03	2.95
421718	AL117574	Hs. 193602	Homo sapiens mRNA; cDNA DKFZp434L2221 (f	1.71E−04	2.94
450256	AA286887	Hs. 24724	MFH-amplified sequences with leucine-ric	7.26E−05	2.94
401898			NM_024722*: Homo sapiens hypothetical pro	4.00E−03	2.94
458368	BE504731	Hs. 138827	ESTs	2.92E−03	2.94
456563	AA989220	Hs. 766	ESTs	1.51E−02	2.93
402836			ENSP00000251163*: Membrane-associated gua	3.86E−02	2.92
409444	H47933	Hs. 33983	ESTs, Weakly similar to ALU6_HUMAN ALU S	1.08E−04	2.92
418522	AA605038	Hs. 7149	Homo sapiens cDNA: FLJ21950 fis, clone H	4.30E−04	2.92
423129	L44396	Hs. 124106	Homo sapiens cDNA FLJ11941 fis, clone HE	4.77E−03	2.92
426279	AI648520	Hs. 169084	tubby like protein 3	1.75E−02	2.92
441969	AI733386		ESTs, Weakly similar to ALU1_HUMAN ALU S	7.20E−04	2.92
446552	AW470827	Hs. 156241	ESTs	2.02E−04	2.92
451644	N23235	Hs. 30567	ESTs, Weakly similar to B34087 hypotheti	2.25E−04	2.92
403330			Target Exon	7.23E−04	2.92
414617	AI339520	Hs. 288817	ESTs, Moderately similar to N Chain N, M	3.77E−05	2.92
459436	AA323121		gb: EST25881 Cerebellum II Homo sapiens c	6.52E−04	2.91
420181	AI380089	Hs. 158951	ESTs	7.30E−03	2.91
447002	BE242866	Hs. 16933	HepA-related protein	2.49E−06	2.91
408212	AA297567	Hs. 43728	hypothetical protein	1.19E−03	2.91
417008	AA191708	Hs. 325825	Homo sapiens cDNA FLJ20848 fis, clone AD	1.52E−03	2.90
434263	N34895	Hs. 79187	ESTs	7.62E−03	2.90
403743			C1002604: gi|8393668|ref|NP 058989.1|kin	7.94E−03	2.90
414429	R51494	Hs. 71818	ESTs	9.10E−02	2.90
420265	AA766209	Hs. 88087	ESTs	2.93E−02	2.90
420683	AA830168	Hs. 271305	ESTs	1.06E−02	2.90
426590	AA617830	Hs. 28310	ESTs	2.02E−03	2.90
428738	NM_000380	Hs. 192803	xeroderma pigmentosum, complementation g	1.25E−03	2.90
437108	AA434054	Hs. 80624	hypothetical protein MGC2560	1.75E−02	2.90
451078	AI927694	Hs. 340945	ESTs	8.83E−02	2.90
442439	U09759	Hs. 246857	mitogen-activated protein kinase 9	7.24E−05	2.90
409939	AA463437	Hs. 11556	Homo sapiens cDNA FLJ12566 fis, clone NT	2.52E−04	2.90
414493	AL133921	Hs. 76272	retinoblastoma-binding protein 2	1.58E−05	2.90
434045	AI065133	Hs. 152316	hypothetical protein PRO0971	9.77E−04	2.90
440668	AI989538	Hs. 191074	ESTs	2.22E−03	2.89
446217	AI651594	Hs. 99709	ESTs	4.26E−07	2.89
438914	N93892	Hs. 10727	ESTs	2.11E−02	2.89
443303	U67319	Hs. 9216	caspase 7, apoptosis-related cysteine pr	1.81E−04	2.89
418584	NM_004606	Hs. 1179	TATA box binding protein (TBP)-associate	3.66E−03	2.88
428695	AI355647	Hs. 189999	purinergic receptor (family A group 5)	4.24E−05	2.88
436372	AW972301	Hs. 310286	ESTs	1.03E−04	2.87
411360	AK001601	Hs. 69594	high-mobility group 20A	3.61E−02	2.87
437456	AL047045	Hs. 60293	Homo sapiens clone 122482 unknown mRNA	2.55E−03	2.86
448198	BE622100	Hs. 209406	ESTs, Weakly similar to I38600 zinc fing	5.39E−05	2.86
428974	AA442693	Hs. 272006	ESTs, Weakly similar to I38022 hypotheti	3.33E−05	2.86
423568	NM_005256	Hs. 129818	growth arrest-specific 2	5.04E−04	2.85
418796	AA228351	Hs. 34060	ESTs	2.79E−04	2.85
406274			Target Exon	4.78E−04	2.85
427209	H06509	Hs. 92423	KIAA1566 protein	2.61E−05	2.85
430280	AA361258	Hs. 237868	interleukin 7 receptor	2.11E−03	2.85
440760	AK001145	Hs. 284216	hypothetical protein FLJ10283	3.19E−03	2.85
415914	AA306033	Hs. 78915	GA-binding protein transcription factor,	7.37E−02	2.85
448569	BE382657	Hs. 21486	signal transducer and activator of trans	1.75E−07	2.84
425284	AF155568		NS1-associated protein 1	1.59E−03	2.84
422614	AI908006	Hs. 295362	Homo sapiens cDNA FLJ14459 fis, clone HE	6.44E−03	2.84
424755	AB033094	Hs. 152925	KIAA1268 protein	1.08E−06	2.83
411617	AA247994		neurocalcin delta	2.63E−02	2.83
452699	AW295390	Hs. 213062	ESTs	8.27E−03	2.83
401197			ENSP00000229263*: HSPC213.	4.72E−02	2.82
409205	AI952884	Hs. 14832	ESTs, Moderately similar to unnamed prot	1.06E−02	2.82
429503	AA394183	Hs. 204166	ESTs	3.50E−03	2.82
436114	AA778232	Hs. 19515	ESTs, Highly similar to NRG3_HUMAN PRO-N	8.26E−03	2.82
445564	AB028957	Hs. 12896	KIAA1034 protein	1.50E−02	2.82
443280	AA299688	Hs. 24183	ESTs	2.55E−03	2.82
410541	AA065003	Hs. 64179	syntenin-2 protein	2.55E−03	2.82
439653	AW021103	Hs. 6631	hypothetical protein FLJ20373	6.73E−03	2.82
446238	T95143	Hs. 14511	SCO (cytochrome oxidase deficient, yeast	3.13E−04	2.82
428418	AI368826	Hs. 8768	ESTs	6.46E−05	2.81
431392	AI371223	Hs. 288671	Homo sapiens cDNA FLJ11997 fis, clone HE	6.18E−03	2.81
434519	AA635727	Hs. 136581	ESTs, Weakly similar to ARNO_HUMAN ARF N	2.32E−03	2.80
430027	AB023197	Hs. 227743	KIAA0980 protein	1.90E−06	2.80
425836	AW955696	Hs. 90960	ESTs	4.78E−05	2.80
428821	H91282	Hs. 286232	Homo sapiens cDNA: FLJ23190 fis, clone L	8.62E−03	2.80
439773	AI051313	Hs. 143315	ESTs	5.41E−03	2.80
432485	N90866	Hs. 276770	CDW52 antigen (CAMPATH-1 antigen)	1.01E−06	2.80
456508	AA502764	Hs. 123469	ESTs, Weakly similar to AF208855 1 BM-01	4.98E−03	2.79
436235	AI084982	Hs. 120790	ESTs	8.15E−05	2.79
421446	AA682425	Hs. 118959	ESTs	1.34E−02	2.78
421524	AA312082	Hs. 105445	GDNF family receptor alpha 1	1.69E−05	2.77
421743	T35958	Hs. 107614	DKFZP564I1171 protein	3.48E−04	2.76
404676			Target Exon	7.31E−03	2.75
411352	NM_002890	Hs. 758	RAS p21 protein activator (GTPase activa	1.59E−03	2.75
424381	AA285249	Hs. 146329	protein kinase Chk2 (CHEK2)	2.54E−02	2.75
426416	AW612744	Hs. 169824	killer cell lectin-like receptor subfami	2.18E−02	2.75
432134	AI816782	Hs. 122583	hypothetical protein FLJ21934	1.84E−03	2.75
434521	NM_002267	Hs. 3886	karyopherin alpha 3 (importin alpha 4)	221E−03	2.75
434963	AW974957	Hs. 288719	Homo sapiens cDNA FLJ12142 fis, clone MA	2.63E−02	2.75
436184	BE154067	Hs. 136660	ESTs, Weakly similar to ZN91_HUMAN ZINC	3.20E−03	2.75
439605	AF086431	Hs. 22380	ESTs	8.61E−05	2.75
449259	AW452058	Hs. 257519	ESTs	3.66E−04	2.75
452057	AW952005	Hs. 14928	hypothetical protein FLJ12903	3.83E−03	2.75
422231	AA443512	Hs. 101383	ESTs	1.84E−03	2.75
418941	AA452970	Hs. 239527	E1B-55 kDa-associated protein 5	5.56E−02	2.74
424637	NM_015057	Hs. 151411	KIAA0916 protein	8.30E−06	2.74
436741	AA860163	Hs. 291319	ESTs	2.79E−03	2.72
439462	AL133026	Hs. 6567	Homo sapiens mRNA; cDNA DKF2p434C136 (fr	1.31E−03	2.72
414522	AW518944	Hs. 76325	Immunoglobulin J chain	2.12E−03	2.72
426125	X87241	Hs. 166994	FAT tumor suppressor (Drosophila) homolo	6.94E−02	2.72
427297	AW292593	Hs. 334907	Homo sapiens, clone MGC: 17333, mRNA, com	2.02E−04	2.72
423067	AA321355	Hs. 285401	colony stimulating factor 2 receptor, be	6.17E−03	2.72
444745	AF117754	Hs. 11861	thyroid hormone receptor-associated prot	9.77E−04	2.72
420962	NM_005904	Hs. 100602	MAD (mothers against decapentaplegic, Dr	1.68E−05	2.72
435427	AA682573	Hs. 188982	ESTs, Weakly similar to organic anion tr	1.67E−03	2.71
453779	N35187	Hs. 43388	28 kD interferon responsive protein	3.17E−07	2.71
439559	AW364675	Hs. 173921	ESTs, Weakly similar to 2109260A B cell	1.25E−03	2.71
451119	AA805417	Hs. 64753	ESTs	7.60E−03	2.70
420825	AI656727	Hs. 194657	gb: tt53f12.x1 NCI_CGAP_GC6 Homo sapiens	5.58E−04	2.70
440538	W76332	Hs. 79107	mitogen-activated protein kinase 14	1.45E−02	2.70
407796	AA195509	Hs. 39733	postsynaptic protein CRIPT	3.49E−03	2.70
401635			C11000702: gi|10048448|ref|NP_065258.1|g	1.24E−02	2.70
408051	AI623351	Hs. 172148	ESTs	3.04E−02	2.70
411213	AA676939	Hs. 69285	neuropilin 1	1.45E−02	2.70
412935	BE267045	Hs. 75064	tubulin-specific chaperone c	1.49E−05	2.70
416048	H16268		gb: ym22a06.r1 Soares infant brain 1NIB H	4.07E−04	2.70
445715	AB012958	Hs. 13137	UV radiation resistance associated gene	3.48E−04	2.70
437145	AF007216	Hs. 5462	solute carrier family 4, sodium bicarbon	1.29E−02	2.69
414404	W16712		KIAA0306 protein	3.99E−05	2.68
420058	AK001423	Hs. 94694	Homo sapiens cDNA FLJ10561 fis, clone NT	1.91E−05	2.68
417558	AF045229	Hs. 82280	regulator of G-protein signalling 10	2.54E−02	2.68
420339	AW968259	Hs. 186647	ESTs	1.62E−04	2.68
419497	NM_006410	Hs. 90753	Tat-interacting protein (30 kD)	1.51E−03	2.67
426797	AW936258	Hs. 342849	ADP-ribosylation factor-like 5	8.07E−02	2.67
430594	AK000790	Hs. 246885	hypothetical protein FLJ20783	4.88E−02	2.67
433312	AI241331	Hs. 131765	ESTs, Moderately similar to I38937 DNA/R	7.59E−04	2.67
437838	AI307229		ESTs	1.19E−03	2.67
438182	AW342140	Hs. 182545	ESTs, Weakly similar to ALU1_HUMAN ALU S	7.69E−05	2.67
450468	AW379075	Hs. 141742	Homo sapiens cDNA FLJ12211 fis, clone MA	5.67E−03	2.67
431315	AW972227	Hs. 163986	Homo sapiens cDNA: FLJ22765 fis, clone K	2.81E−04	2.67
425548	AA890023	Hs. 1906	prolactin receptor	7.58E−04	2.67
434669	AF151534	Hs92023	core histone macroH2A2.2	6.01E−06	2.67
409600	AJ011679	Hs. 55099	rab6 GTPase activating protein (GAP and	1.08E−04	2.66
417928	AA209344	Hs. 30177	ESTs	1.81E−04	2.66
418832	X04011	Hs. 88974	cytochrome b-245, beta polypeptide (chro	2.52E−04	2.66
452696	AI826645	Hs. 211534	ESTs	2.45E−05	2.66
426126	AL118747	Hs. 26691	ESTs	6.18E−04	2.66
427528	AU077143	Hs. 179565	minichromosome maintenance deficient (S.	2.45E−05	2.65
434384	AA631910		ESTs	2.79E−03	2.65
440529	AW207640	Hs. 16478	Homo sapiens cDNA: FLJ21718 fis, clone C	8.62E−03	2.65
446830	BE179030		Human DNA sequence from clone RP5-1174N9	6.85E−04	2.65
443405	AF031463	Hs. 9302	phosducin-like	2.65E−04	2.65
407807	AL031427	Hs. 40094	Human DNA sequence from clone 167A19 on	2.43E−03	2.65
421919	AJ224901	Hs. 109526	zinc finger protein 198	1.38E−03	2.64
429617	X89984	Hs. 211563	B-cell CLL/lymphoma 7A	3.65E−03	2.63
403976			Target Exon	2.43E−03	2.63
435631	BE254086	Hs. 29647	uncharacterized hematopoietic stem/proge	7.30E−03	2.63
447657	AI953011		ESTs	1.52E−03	2.63
412520	AA442324	Hs. 795	H2A histone family, member O	5.74E−05	2.62
417317	AW296584	Hs. 293782	ESTs	5.71E−05	2.62
450331	AA009536	Hs. 38323	ESTs	1.10E−02	2.61
438441	AW664960	Hs. 205319	ESTs	2.26E−04	2.61
413836	W92003	Hs. 70614	ESTs	1.24E−02	2.61
446006	NM_004403	Hs. 13530	deafness, autosomal dominant 5	1.45E−02	2.60
431214	AA294921	Hs. 348024	v-ral simian leukemia viral oncogene horn	1.39E−02	2.60
422283	AW411307	Hs. 114311	CDC45 (cell division cycle 45, S.cerevis	1.08E−04	2.60
425118	AU076611	Hs. 154672	methylene tetrahydrofolate dehydrogenase	9.36E−03	2.60
442432	BE093589	Hs. 38178	hypothetical protein FLJ23468	6.43E−05	2.60
452014	AI828174	Hs. 227049	ESTs	1.39E−02	2.60
408138	AA535740		tumor protein p53-binding protein, 1	1.75E−02	2.60
457819	AA057484	Hs. 35406	ESTs, Highly similar to unnamed protein	2.27E−02	2.60
451578	NM_016323	Hs. 26663	cyclin-E binding protein 1	1.16E−06	2.59
428330	L22524	Hs. 2256	matrix metalloproteinase 7 (matrilysin,	1.51E−02	2.59
444057	AA316896	Hs. 257267	FYVE and coiled-coil domain containing 1	2.26E−04	2.58
401928			Target Exon	7.00E−03	2.57
424375	AF070547	Hs. 146312	Homo sapiens clone 24820 mRNA sequence	3.87E−02	2.57
445106	T10219	Hs. 12329	KIAA0697 protein	7.60E−04	2.57
447211	AL161961	Hs. 17767	KIAA1554 protein	3.68E−07	2.57
427704	AW971063	Hs. 292882	ESTs	7.84E−02	2.56
430399	AI916284	Hs. 199671	ESTs	5.58E−04	2.56
422461	NM_003417	Hs. 117077	zinc finger protein 264	1.30E−03	2.56
401952			Target Exon	1.05E−02	2.56
422392	NM_005908	Hs. 115945	mannosidase, beta A, lysosomal	7.14E−02	2.56
422722	H74219	Hs. 269772	ESTs	1.44E−03	2.56
414279	AW021691		GCN5 (general control of amino-acid synt	9.09E−02	2.55
446934	AK001943	Hs. 16577	F-box only protein 3	5.20E−03	2.55
434948	AI498469	Hs. 12622	ESTs, Highly similar to AF161436 1 HSPC3	2.73E−02	2.55
438865	H64256	Hs. 167619	ESTs, Moderately similar to ALUC_HUMAN!	8.08E−02	2.55
439372	AF088033	Hs. 159225	ESTs	3.25E−02	2.55
445757	AW449065	Hs. 13264	KIAA0856 protein	3.35E−03	2.55
409614	BE297412	Hs. 55189	hypothetical protein	2.74E−07	2.55
423932	T95633	Hs. 189703	ESTs	4.73E−02	2.55
451743	AW074266	Hs. 23071	ESTs	8.16E−05	2.54
416272	AA178882		gb: zp38b09.r1 Stratagene muscle 937209 H	1.29E−02	2.53
446161	AA628206	Hs. 14125	p53 regulated PA26 nuclear protein	1.45E−03	2.53
425303	AA354785		gb: EST63098 Jurkat T-cells V Homo sapien	2.04E−02	2.53
451253	H48299	Hs. 26126	claudin 10	1.38E−03	2.52
408340	AB037762	Hs. 44268	myelin gene expression factor 2	6.42E−05	2.52
410678	BE540516	Hs. 293732	hypothetical protein MGC3195	1.31E−03	2.52
414792	BE314949	Hs. 87128	hypothetical protein FLJ23309	4.23E−06	2.52
447387	AI268331	Hs. 102237	tubby super-family protein	3.51E−06	2.52
407765	AW076027	Hs. 257711	ESTs, Moderately similar to ALU8_HUMAN A	3.49E−02	2.51
421471	U90545	Hs. 327179	solute carrier family 17 (sodium phospha	2.19E−02	2.51
438980	AW502384		gb: UI-HF-BR0p-aka-f-12-0-UI.r1 NIH_MGC_5	1.39E−02	2.51
453906	AW444952	Hs. 257054	ESTs	3.83E−03	2.51
414760	BE298063	Hs. 77254	chromobox homolog 1 (Drosophila HP1 beta	8.78E−07	2.51
434822	AW076088	Hs. 4187	hypothetical protein 24636	2.38E−04	2.51
458079	AI796870	Hs. 54277	DNA segment on chromosome X (unique) 992	1.15E−05	2.50
408521	AA055264	Hs. 260848	ESTs, Weakly similar to S23650 retroviru	1.39E−05	2.50
409161	W07662	Hs. 50861	sirtuin (silent mating type information	5.39E−05	2.50
411931	AW675180	Hs. 36828	ESTs	2.28E−02	2.50
414172	AW954324	Hs. 75790	phosphatidylinositol glycan, class C	4.17E−03	2.50
414502	AL133721	Hs. 224680	ESTs	6.44E−03	2.50
420613	AI873871	Hs. 7041	ESTs, Weakly similar to A47582 B-cell gr	4.60E−06	2.50
422195	AB007903	Hs. 113082	KIAA0443 gene product	1.89E−02	2.50
423645	AI215632	Hs. 147487	ESTs	1.62E−04	2.50
427210	BE396283	Hs. 173987	eukaryotic translation initiation factor	1.96E−02	2.50
430273	AI311127	Hs. 125522	ESTs	1.25E−03	2.50
445664	AW968638	Hs. 237691	ESTs, Weakly similar to KIAA0601 protein	4.30E−04	2.50
437708	AB033020	Hs. 5801	KIAA1194 protein	8.63E−05	2.50
439748	AL389934	Hs. 23248	hypothetical protein from EUROIMAGE 2005	6.71E−03	2.50
435727	T78475	Hs. 269542	ESTs, Weakly similar to S65657 alpha-1C-	1.19E−02	2.49
414602	AW630088	Hs. 76550	Homo sapiens mRNA; cDNA DKFZp564B1264 (f	7.23E−04	2.49
451693	BE220445	Hs. 279635	ESTs	1.29E−02	2.49
443849	BE566066	Hs. 9893	ASB-3 protein	2.79E−03	2.48
421405	AA251944	Hs. 104058	CGI-29 protein	7.60E−04	2.48
446591	H44186	Hs. 15456	PDZ domain containing 1	2.68E−06	2.48
432348	AA534353	Hs. 194081	ESTs, Weakly similar to I38022 hypotheti	4.76E−03	2.48
415323	BE269352	Hs. 949	neutrophil cytosolic factor 2 (65 kD, chr	2.73E−02	2.48
416436	H55746	Hs. 28704	ESTs, Weakly similar to A45910 ultra-hig	2.20E−02	2.48
446044	H67567	Hs. 13572	calcium modulating ligand	2.03E−06	2.48
446771	AA128965	Hs. 60679	TATA box binding protein (TBP)-associate	7.27E−05	2.48
407112	AA070801	Hs. 51615	ESTs, Weakly similar to ALU7_HUMAN ALU S	7.60E−02	2.47
410196	AI936442	Hs. 59838	hypothetical protein FLJ10808	3.30E−04	2.47
427254	AL121523	Hs. 97774	ESTs	9.75E−03	2.47
430487	D87742	Hs. 241552	KIAA0268 protein	7.98E−04	2.47
452480	AI903526		gb: RC-BT031-090199-063 BT031 Homo sapien	1.51E−02	2.47
422473	U94780	Hs. 117242	meningioma expressed antigen 6 (coiled-c	7.00E−03	2.47
405117			C11000181*: gi|7305349|ref|NP_038647.1|o	1.37E−03	2.47
449082	BE387561	Hs. 22981	DKFZP586M1523 protein	6.16E−04	2.47
439815	AA206079	Hs. 6693	hypothetical protein FLJ20420	2.02E−04	2.47
408145	AF182316	Hs. 234680	fer-1 (C. elegans)-like 3 (myofertin)	5.38E−02	2.47
448122	AW665656	Hs. 173187	ESTs	5.92E−02	2.47
414895	AW894856	Hs. 116278	Homo sapiens cDNA FLJ13571 fis, clone PL	3.82E−03	2.46
439747	AK001148	Hs. 6671	COP9 complex subunit 4	6.85E−04	2.46
440706	AA927562	Hs. 148234	ESTs	2.79E−03	2.46
400557			Target Exon	3.14E−02	2.46
456721	AA533356		gb: nj67f10.s1 NCI_CGAP_Pr10 Homo sapiens	4.00E−03	2.45
416354	NM_000633	Hs. 79241	B-cell CLL/lymphoma 2 (BCL2)	5.04E−04	2.45
418203	X54942	Hs. 83758	CDC28 protein kinase 2	4.57E−03	2.45
423983	AA333261		gb: EST37476 Embryo, 8 week 1 Homo sapien	1.10E−02	2.45
434128	W93170	Hs. 284164	protein x 0004	1.62E−04	2.45
438141	AW946871		gb: RC2-ET0022-080500-012-d02 ET0022 Homo	3.34E−03	2.45
449239	T24653	Hs. 23360	likely ortholog of yeast ARV1	3.06E−06	2.45
422241	Y00062	Hs. 170121	protein tyrosine phosphatase, receptor t	1.49E−05	2.45
414462	BE622743	Hs. 301064	arfaptin 1	5.44E−03	2.44
423706	U95218	Hs. 131924	G protein-coupled receptor 65	2.55E−03	2.44
431661	AB037830	Hs. 267150	KIAA1409 protein	1.71E−04	2.44
413856	D13639	Hs. 75586	cyclin D2	4.57E−03	2.44
422684	BE561617	Hs. 119192	H2A histone family, member Z	6.72E−03	2.44
420623	BE245485	Hs. 99437	Homo sapiens mRNA; cDNA DKFZp586G1924 (f	6.45E−03	2.43
417377	NM_016603	Hs. 82035	potential nuclear protein C5ORF5; GAP-li	1.79E−05	2.43
409884	AI904455	Hs. 142684	hypothetical protein DKFZp667O116	1.59E−03	2.43
452748	AB011128	Hs. 30512	Homo sapiens mRNA for KIAA0556 protein,	1.31E−03	2.43
434500	AF143877	Hs. 215047	Homo sapiens clone IMAGE: 113431 mRNA seq	3.49E−02	2.43
436021	R26877	Hs. 24128	ESTs	3.25E−02	2.42
442149	AB014550	Hs. 8118	KIAA0650 protein	3.50E−03	2.42
408411	C15118	Hs. 322482	hypothetical protein DKFZp566J2046	9.48E−06	2.42
407656	AW747986	Hs. 37443	Homo sapiens mRNA; cDNA DKFZp434B2119 (f	4.08E−04	2.42
430587	AK000341	Hs. 246107	elongation of very long chain fatty acid	4.52E−05	2.41
412019	AA485890	Hs. 69330	Homo sapiens cDNA FLJ13835 fis, clone TH	1.81E−04	2.41
457650	AA649162	Hs. 236456	ESTs	4.25E−05	2.41
458971	AL119206	Hs. 101874	ESTs, Weakly similar to ALU1_HUMAN ALU S	2.28E−02	2.41
433902	AW292820	Hs. 144906	ESTs	5.91E−03	2.41
439645	BE091801	Hs. 27167	ESTs, Weakly similar to I38022 hypotheti	1.77E−06	2.41
430007	NM_014892	Hs. 227602	KIAA1116 protein	2.32E−03	2.41
427547	BE047653	Hs. 119183	ESTs, Weakly similar to ZN91_HUMAN ZINC	3.49E−03	2.41
448749	AW859679	Hs. 21902	Homo sapiens clone 25237 mRNA sequence	1.84E−03	2.40
444913	AI362726	Hs. 193656	Homo sapiens mRNA for KIAA1658 protein,	5.39E−05	2.40
428466	AF151063	Hs. 184456	hypothetical protein	4.00E−03	2.40
408636	BE294925	Hs. 46680	CGI-12 protein	3.06E−03	2.40
416517	AA775987	Hs. 79357	proteasome (prosome, macropain) 26S subu	1.06E−02	2.40
438041	AI394551		ESTs	4.56E−02	2.40
444088	AW297946	Hs. 138208	ESTs	2.54E−02	2.40
449118	R67477	Hs. 23103	Bet1 (S. cerevisiae) homolog	2.93E−02	2.40
452253	AA928891	Hs. 28608	Homo sapiens cDNA: FLJ22115 fis. clone H	1.18E−03	2.40
435872	AA701357	Hs. 192759	ESTs	1.59E−03	2.40
409132	AJ224538	Hs. 50732	protein kinase, AMP-activated, beta 2 no	1.25E−06	2.40
414256	AW410035	Hs. 75862	MAD (mothers against decapentaplegic, Dr	2.93E−02	2.39
459680	H96982	Hs. 42321	ESTs	2.14E−04	2.39
427657	AV652249	Hs. 180107	polymerase (DNA directed), beta	7.07E−07	2.39
446570	AV659177	Hs. 127160	ESTs	2.31E−05	2.38
415668	AW957684	Hs. 306814	hypothetical protein FLJ21889	4.57E−02	2.38
428985	AL134193	Hs. 194709	paraneoplastic antigen MA1	4.00E−03	2.38
438030	X98427	Hs. 122634	ESTs	2.33E−03	2.38
457605	AV657778	Hs. 3314	selenoprotein P, plasma, 1	2.32E−03	2.38
422043	AL133649	Hs. 110953	retinoic acid induced 1	1.31E−03	2.38
425375	AA631977	Hs. 155995	KIAA0643 protein	2.44E−05	2.38
427020	AA397546	Hs. 119151	ESTs	1.01E−02	2.38
440341	AW664012	Hs. 132333	ESTs	1.93E−03	2.38
424321	W74048	Hs. 1765	lymphocyte-specific protein tyrosine kin	2.38E−04	2.37
416611	AA568308		ESTs, Weakly similar to ALU6_HUMAN ALU S	2.67E−03	2.37
416065	BE267931	Hs. 78996	proliferating cell nuclear antigen	6.21E−04	2.37
419424	BE041820	Hs. 38516	Homo sapiens, clone MGC: 15887, mRNA, com	4.30E−04	2.36
452207	NM_014517	Hs. 28423	upstream binding protein 1 (LBP-1a)	5.71E−05	2.36
414496	W73853		ESTs	1.92E−03	2.36
451107	AA235108	Hs. 17639	Homo sapiens ubiquitin protein ligase (U	7.59E−04	2.35
452685	AI634651	Hs. 30250	v-maf musculoaponeurotic fibrosarcoma (a	6.41E−06	2.35
411196	W31212	Hs. 69192	vacuolar protein sorting 29 (yeast homol	2.45E−02	2.35
427647	W19744	Hs. 180059	Homo sapiens cDNA FLJ20653 fis, clone KA	1.62E−04	2.35
422607	Z45471	Hs. 118684	stromal cell-derived factor 2	4.30E−04	2.35
427469	AA403084	Hs. 269347	ESTs, Weakly similar to 2109260A B cell	9.74E−03	2.35
429065	AI753247	Hs. 29643	Homo sapiens cDNA FLJ13103 fis, clone NT	1.06E−02	2.35
439103	AF085959	Hs. 38705	ESTs	2.43E−03	2.35
427094	AB025254	Hs. 283761	tudor repeat associated with PCTAIRE 2	7.02E−07	2.35
451789	AW291532	Hs. 211297	ESTs	3.20E−03	2.35
414436	U50078	Hs. 76127	hect (homologous to the E6-AP (UBE3A) ca	5.43E−03	2.35
446487	AA195526	Hs. 44625	Rad50-interacting protein 1	2.79E−03	2.34
411580	AL080088	Hs. 70877	DKFZP564K2062 protein	1.80E−04	2.34
413880	AI660842	Hs. 110915	interleukin 22 receptor	5.87E−04	2.33
431899	AA521381	Hs. 187726	ESTs	1.06E−02	2.33
450607	AL050373	Hs. 25213	hypothetical protein	2.30E−05	2.33
440726	AL050333	Hs. 306425	DKFZP564B116 protein	4.14E−02	2.33
417089	H52280	Hs. 18612	Homo sapiens cDNA: FLJ21909 fis, clone H	1.17E−06	2.33
450919	AA011616	Hs. 269877	ESTs	6.72E−03	2.33
414312	AA155694	Hs. 191060	ESTs	5.88E−04	2.32
421025	AW958975	Hs. 29397	Homo sapiens cDNA FLJ13226 fis, clone OV	2.26E−04	2.32
439556	AI623752	Hs. 163603	ESTs	2.36E−02	2.32
424528	AW073971	Hs. 238954	ESTs, Weakly similar to KIAA1204 protein	1.25E−03	2.32
423365	AA324992	Hs. 257168	ESTs	3.20E−03	2.32
403920			suppressor of potassium transport defect	4.14E−02	2.32
448280	AW014215	Hs. 357	zinc finger protein 134 (clone pHZ-15)	2.54E−03	2.32
407687	AK002011	Hs. 37558	hypothetical protein FLJ11149	3.99E−03	2.31
409259	AW608930	Hs. 52184	hypothetical protein FLJ20618	2.16E−06	2.30
407804	AF228603	Hs. 39957	pleckstrin 2 (mouse) homolog	5.21E−03	2.30
423968	AF098277	Hs. 136529	solute carrier family 23 (nucleobase tra	1.31E−05	2.30
414525	C14904	Hs. 45184	Homo sapiens cDNA FLJ12284 fis, clone MA	1.44E−03	2.30
420164	AW339037	Hs. 24908	ESTs	2.63E−02	2.30
422900	AA641201	Hs. 222051	ESTs	1.08E−03	2.30
423799	AW026300	Hs. 132906	19A24 protein	3.35E−03	2.30
440390	AW207385	Hs. 36475	KIAA0493 protein	1.92E−03	2.30
456351	AW971067	Hs. 293056	ESTs, Weakly similar to 138022 hypotheti	3.50E−03	2.30
431341	AA307211	Hs. 251531	proteasome (prosome, macropain) subunit.	1.22E−04	2.30
413029	AL119399	Hs. 293850	ESTs	5.05E−05	2.30
453315	BE544203	Hs. 24831	ESTs	8.62E−03	2.30
433160	AW207002	Hs. 134342	TASP for testis-specific adriamycin sens	1.96E−02	2.30
420137	AA306478	Hs. 95327	CD3D antigen, delta polypeptide (TiT3 co	6.39E−06	2.30
436252	AI539519	Hs. 120969	Homo sapiens cDNA FLJ11562 fis, clone HE	1.03E-−03	2.30
437143	AW204056	Hs. 8917	ESTs	6.58E−07	2.30
440495	AA887212	Hs. 14161	hypothetical protein DKFZp43411930	1.75E−03	2.30
419203	AA488719	Hs. 190151	ESTs	8.98E−03	2.30
410017	AW952426	Hs. 109438	Homo sapiens clone 24775 mRNA sequence	2.02E−04	2.29
415173	AW501735	Hs. 180059	ESTs	4.28E−02	2.29
419200	AW966405		prefoldin 5	7.61E−07	2.29
437109	AW006781	Hs. 5457	hypothetical protein FLJ10738	3.12E−04	2.29
438475	W03856	Hs. 13188	ESTs, Highly similar to Gene product wit	5.26E−06	2.28
417206	AA291183	Hs. 81648	hypothetical protein FLJ11021 similar to	2.66E−03	2.27
448410	AK000227	Hs. 21126	hypothetical protein FLJ20220	7.37E−02	2.27
448959	AI610343	Hs. 293267	ESTs	1.59E−03	2.27
440528	BE313555	Hs. 7252	KIAA1224 protein	1.01E−02	2.27
421620	AA446183	Hs. 91885	ESTs, Weakly similar to 155214 salivary	6.17E−03	2.27
451589	M424791	Hs. 5734	meningioma expressed antigen 5 (hyaluron	4.56E−03	2.27
421931	NM_000814	Hs. 1440	gamma-aminobutyric acid (GABA) A recepto	1.62E−04	2.27
431831	AW023204	Hs. 302743	ESTs	8.40E−04	2.27
428583	AA430589	Hs. 75410	heat shock 70 kD protein 5 (glucose-regul	5.91E−03	2.26
452248	AA093668	Hs. 28578	muscleblind (Drosophila)-like	9.71E−05	2.26
446045	AV656268	Hs. 209153	angiopoietin-like 3	1.13E−03	2.26
421297	AB037360		KIAA1255 protein	3.13E−05	2.26
440945	AW505345	Hs. 7540	f-box and leucine-rich repeat protein 3A	9.10E−02	2.26
452852	AK001972	Hs. 30822	hypothetical protein FLJ11110	1.31E−05	2.26
403496			C3000956*: gi|7710129|ref|NP_006141.2|LI	1.19E−03	2.26
439046	M947354		gb: od86e11.s1 NCI_CGAP_Ov2 Homo sapiens	4.78E−04	2.25
427268	X78520	Hs. 174139	chloride channel 3	6.19E−04	2.25
405122			NM_006798*: Homo sapiens UDP glycosyltran	1.59E−03	2.25
403320			fms-related tyrosine kinase 3	1.89E−02	2.25
416754	H07145	Hs. 6799	ESTs, Weakly similar to T12483 hypotheti	1.52E−03	2.25
418046	W49670	Hs. 56044	ESTs	2.04E−02	2.25
418383	AA218986	Hs. 118854	ESTs	1.96E−02	2.25
429025	AI399910	Hs. 266782	KIAA1826 protein	1.06E−02	2.25
435756	AI418466	Hs. 33665	ESTs	2.01E−03	2.25
440638	AI376551		gb: te64e10.x1 Soares_NFL_T_GBC.S1 Homo s	1.39E−02	2.25
447225	R62676	Hs. 17820	Rho-associated, coiled-coil containing p	2.81E−04	2.25
434747	AA837085		ESTs	1.25E−03	2.24
453041	AI680737	Hs. 289068	Homo sapiens cDNA FLJ11918 fis, clone HE	2.45E−02	2.24
445044	AL137728	Hs. 12258	Homo sapiens mRNA; cDNA DKFZp434B0920 (f	5.56E−02	2.24
448939	BE267795	Hs. 22595	hypothetical protein FLJ10637	1.01E−02	2.24
450196	AW956868	Hs. 24608	DKFZP564D177 protein	4.52E−05	2.23
453929	AW190054		gb: xl11d05.x1 NCI_CGAP_Ut4 Homo sapiens	2.04E−02	2.23
455959	AA131782	Hs. 182314	ESTs	1.10E−02	2.23
446594	AI311917	Hs. 16292	ESTs	9.93E−02	2.23
445893	AI610702	Hs. 202613	ESTs, Weakly similar to TRHY_HUMAN TRICH	1.09E−04	2.23
432476	T94344	Hs. 326263	ESTs	1.56E−02	2.23
448888	AW196663	Hs. 200242	caspase recruitment domain protein 6	7.58E−04	2.23
405270			NM_018850*: Homo sapiens ATP-binding cass	1.02E−02	2.22
442806	AW294522	Hs. 149991	ESTs	2.45E−02	2.22
450314	AA574309	Hs. 283402	TCR eta	4.77E−03	2.22
452144	AA032197	Hs. 102558	Homo sapiens, clone MGC: 5352, mRNA, comp	2.39E−04	2.22
452436	BE077546	Hs. 31447	ESTs, Moderately similar to A46010 X-lin	3.66E−03	2.22
455834	BE145364		gb: IL0-HT0198-151099-125-e05 HT0198 Homo	1.14E−02	2.22
436643	AA757626	Hs. 10941	ESTs, Weakly similar to IPP1_HUMAN PROTE	5.03E−04	2.22
448558	AW340579	Hs. 171165	ESTs	6.51E−04	2.22
414091	T83742	Hs. 334616	gb: yd67g02.s1 Soares fetal liver spleen	2.80E−04	2.21
421958	AA357185	Hs. 109918	ras homolog gene family, member H	5.58E−04	2.21
433648	AA603388	Hs. 44131	KIAA0974 protein	1.75E−03	2.21
428004	AA449563	Hs. 151393	glutamate-cysteine ligase, catalytic sub	4.72E−02	2.21
446229	AI744964	Hs. 14449	KIAA1609 protein	5.58E−04	2.21
421921	H83363		translocase of inner mitochondrial membr	8.81E−04	2.20
408866	AW292096	Hs. 255036	ESTs	1.14E−02	2.20
400120			Eos Control	1.82E−02	2.20
415000	AW025529	Hs. 239812	Homo sapiens serologically defined breas	1.61E−04	2.20
408990	AL022395	Hs. 49526	f-box and leucine-rich repeat protein 4	3.19E−03	2.20
422371	NM_001882	Hs. 115617	corticotropin releasing hormone-binding	1.15E−04	2.20
437580	AA761075		ESTs	2.04E−02	2.20
453927	AA082465	Hs. 125031	choline/ethanolaminephosphotransferase	4.60E−06	2.20
405688			NM_018850*: Homo sapiens ATP-binding cass	2.52E−04	2.20
427130	AB029020	Hs. 173694	KIAA1097 protein	6.45E−05	2.20
414718	H95348	Hs. 107987	ESTs	1.96E−02	2.20
409549	AB029015	Hs. 54886	phospholipase C, epsilon 2	1.51E−03	2.20
424904	AI221739	Hs. 96899	ESTs	8.95E−03	2.20
449103	T24968	Hs. 23038	HSPC071 protein	3.87E−04	2.20
413326	H88621	Hs. 19762	ESTs, Weakly similar to KIAA1140 protein	2.63E−02	2.19
426011	AW996096	Hs. 58924	ESTs, Weakly similar to JC5594 jerky gen	1.67E−03	2.19
443352	H70284	Hs. 160152	ESTs, Weakly similar to FPHU alpha-fetop	9.75E−03	2.19
427156	BE621719	Hs. 173802	KIAA0603 gene product	4.14E−02	2.19
418980	T77130	Hs. 268606	ESTs	3.60E−02	2.19
425745	U44060	Hs. 159437	Homo sapiens cDNA: FLJ21800 fis, clone H	2.55E−03	2.19
433162	AI025842		ESTs	2.96E−04	2.19
412240	H72176		hypothetical protein FLJ13159	3.35E−03	2.19
440113	AI916532	Hs. 188272	ESTs	4.35E−03	2.19
430526	AF181862	Hs. 242407	G protein-coupled receptor, family C, gr	2.81E−04	2.18
447881	BE620886		GCN1 (general control of amino-acid synt	1.51E−02	2.18
407151	H25836	Hs. 301527	ESTs, Moderately similar to unknown [H.s	4.59E−07	2.18
411590	T96183		gb: ye09f07.s1 Stratagene lung (937210) H	3.04E−02	2.18
413823	AI341417	Hs. 29406	ESTs	6.00E−06	2.18
401627			Target Exon	8.62E−03	2.18
414588	AA302905		gb: EST10607 Adipose tissue, white I Homo	9.77E−04	2.18
425508	AA991551	Hs. 97013	Homo sapiens, Similar to RIKEN cDNA 2310	8.14E−05	2.18
434260	AF121856	Hs. 284291	sorting nexin 6	4.52E−05	2.18
407904	W44735	Hs. 9286	Homo sapiens cDNA: FLJ21278 fis, clone C	8.83E−04	2.17
421077	AK000061	Hs. 101590	hypothetical protein	2.54E−02	2.17
427120	R42099	Hs. 21965	ESTs	1.37E−03	2.17
442129	N36918	Hs. 20142	PNAS-127 protein	4.37E−03	2.17
444291	AI598022	Hs. 193989	TAR DNA binding protein	3.99E−03	2.17
418416	U11700	Hs. 84999	ATPase, Cu transporting, beta polypeptid	1.79E−05	2.17
403576			C3000124: gi|12737057|ref|XP_012129.1|si	5.20E−03	2.17
446126	AW085909		pleckstrin homology domain interacting p	6.72E−03	2.17
424699	AW206227	Hs. 287727	hypothetical protein FLJ23132	8.99E−03	2.17
437223	C15105	Hs. 330716	Homo sapiens cDNA FLJ14368 fis, clone HE	2.02E−03	2.17
432540	AI821517	Hs. 105866	ESTs	2.35E−02	2.17
425266	J00077	Hs. 155421	alpha-fetoprotein	1.14E−02	2.17
438619	AB032773		TU12B1-TY protein	3.86E−02	2.17
442053	R35343	Hs. 24968	Human DNA sequence from clone RP1-233G16	9.74E−03	2.16
430308	BE540865	Hs. 238990	cyclin-dependent kinase inhibitor 1B (p2	4.25E−05	2.16
434608	AA805443	Hs. 179909	hypothetical protein FLJ22995	4.37E−03	2.16
408527	AL135018	Hs. 33074	Homo sapiens, clone IMAGE: 3606519, mRNA,	4.28E−02	2.16
410612	AW502698	Hs. 42400	ESTs	9.16E−05	2.16
410800	BE280421	Hs. 94499	ESTs	1.25E−03	2.15
456073	AA587775	Hs. 66295	multi-PDZ-domain-containing protein	3.76E−05	2.15
411468	AW857470		gb: CM3-CT0310-180200-098-g03 CT0310 Homo	1.19E−03	2.15
411979	X85134	Hs. 72984	retinoblastoma-binding protein 5	5.21E−03	2.15
419165	AW860767	Hs. 118879	ESTs	1.14E−02	2.15
419479	AI288348	Hs. 23450	mitochondrial ribosomal protein S25	7.60E−02	2.15
432709	H17238		gb: ym42f03.r1 Soares infant brain 1NIB H	3.65E−03	2.15
448705	H05072	Hs. 124984	ESTs, Moderately similar to ALU7_HUMAN A	6.51E−02	2.15
440266	AA088809	Hs. 19525	hypothetical protein FLJ22794	1.29E−04	2.15
449881	Z28444	Hs. 24119	Homo sapiens mRNA; cDNA DKFZp586G2222 (f	5.68E−03	2.15
457500	NM_002759	Hs. 274382	protein kinase, interferon-inducible dou	1.10E−02	2.15
417713	D42047	Hs. 82432	KIAA0089 protein	3.66E−03	2.14
416269	AA177138	Hs. 161671	ESTs	8.29E−03	2.14
437370	AL359567	Hs. 161962	Homo sapiens mRNA; cDNA DKFZp547D023 (fr	2.55E−03	2.14
413305	NM_000426	Hs. 323511	Homo sapiens cDNA: FLJ23176 fis, clone L	6.93E−02	2.14
413012	D83777	Hs. 75137	KIAA0193 gene product	3.50E−03	2.14
431874	AW610031	Hs. 323914	translocase of inner mitochondrial membr	9.73E−03	2.14
421166	AA305407	Hs. 102308	potassium inwardly-rectifying channel, s	3.06E−03	2.13
414883	AA926960		CDC28 protein kinase 1	6.41E−06	2.13
426685	R20212	Hs. 28454	ESTs	7.31E−03	2.13
407874	AI766311	Hs. 289047	Homo sapiens cDNA FLJ14059 fis, clone HE	4.92E−06	2.13
423703	NM_014913	Hs. 131915	KIAA0863 protein	8.83E−04	2.13
443804	AL135352	Hs. 255883	ESTs, Weakly similar to I38022 hypotheti	1.52E−03	2.13
436100	AA704806	Hs. 143842	ESTs, Weakly similar to 2004399A chromos	8.32E−02	2.13
444931	AV652066	Hs. 75113	general transcription factor IIIA	4.01E−03	2.13
403742			Target Exon	8.00E−04	2.13
407183	AA358015		gb: EST66864 Fetal lung III Homo sapiens	3.47E−04	2.13
430048	T65054	Hs. 73605	ESTs	1.29E−02	2.13
445800	AA126419	Hs. 32944	inositol polyphosphate-4-phosphatase, ty	2.54E−02	2.13
438829	AA826926	Hs. 204214	ESTs, Weakly similar to 138022 hypotheti	1.14E−02	2.12
443189	AB023179	Hs. 9059	KIAA0962 protein	3.49E−03	2.12
421633	AF121860	Hs. 106260	sorting nexin 10	6.51E−02	2.12
408475	AA315514	Hs. 47986	hypothetical protein MGC10940	5.93E−02	2.12
436237	R11528	Hs. 271968	ESTs	2.39E−04	2.12
409509	AL036923	Hs. 322710	ESTs	3.74E−02	2.11
408358	D20044	Hs. 12929	hypothetical protein FLJ20721	2.91E−03	2.11
417867	AW952547	Hs. 194603	ESTs, Moderately similar to I38022 hypot	1.68E−02	2.10
417691	AU076610	Hs. 82399	low density lipoprotein receptor defect	1.19E−03	2.10
439161	Y15164	Hs. 6483	oral-facial-digital syndrome 1	1.84E−03	2.10
441024	AW081530	Hs. 268231	ESTs	7.28E−03	2.10
445817	NM_003642	Hs. 13340	histone acetyltransferase 1	2.12E−03	2.10
446783	AW138343	Hs. 141867	ESTs	9.75E−03	2.10
449901	AI674072		gb: wd15h01.x1 Soares_NFL_T—	2.95E−05	2.10
			GBC_S1 Homo s
456373	BE247706	Hs. 89751	membrane-spanning 4-domains, subfamily A	9.78E−04	2.10
451582	AI963026	Hs. 289958	ESTs, Weakly similar to putative p150 [H	1.24E−02	2.10
432106	N58323	Hs. 269098	ESTs, Weakly similar to RETROVIRUS-RELAT	2.43E−03	2.10
426295	AW367283		zinc finger protein 6 (CMPX1)	1.30E−04	2.09
426272	AW450671	Hs. 189284	ESTs	4.52E−05	2.09
444647	H14718	Hs. 11506	Human clone 23589 mRNA sequence	6.93E−02	2.09
458476	AA336878	Hs. 9842	Human DNA sequence from clone RP4-788L20	2.92E−03	2.09
428220	BE183533	Hs. 347128	Human DNA sequence from clone 34B21 on c	6.84E−06	2.09
446103	U90918	Hs. 13804	hypothetical protein dJ462O23.2	4.76E−03	2.09
431742	NM_016652	Hs. 268281	crooked neck protein (cm)	1.10E−02	2.09
412760	AW379030	Hs. 41324	ESTs	3.99E−05	2.08
450203	AF097994	Hs. 301528	L-kynurenine/alpha-aminoadipate aminotra	8.57E−02	2.08
405086			NM_006662*: Homo sapiens Snf2-related CBP	1.82E−02	2.08
429567	R35606	Hs. 326800	Human EST clone 53125 mariner transposon	2.36E−02	2.08
418459	R85436	Hs. 268814	ESTs	2.21E−03	2.07
424737	BE301883	Hs. 152707	glioblastoma amplified sequence	4.77E−04	2.07
454038	X06374	Hs. 37040	platelet-derived growth factor alpha pol	1.75E−02	2.07
427468	AB036829	Hs. 178347	SKIP for skeletal muscle and kidney enri	1.25E−03	2.07
412748	BE083158	Hs. 10862	Homo sapiens cDNA: FLJ23313 fis, clone H	4.56E−03	2.07
455705	AW161061		ESTs, Weakly similar to zinc finger prot	2.36E−07	2.07
421483	NM_003388	Hs. 104717	hypothetical protein MGC11333	1.19E−02	2.06
433713	AW976511	Hs. 112592	ESTs	2.83E−02	2.06
457171	AA433896	Hs. 201634	ESTs	1.29E−02	2.06
433201	AB040896	Hs. 21104	KIAA1463 protein	7.30E−03	2.06
432841	M93425	Hs. 62	protein tyrosine phosphatase, non-recept	2.83E−02	2.06
437469	AW753112	Hs. 15514	hypothetical protein MGC3260	2.92E−03	2.06
402929			ENSP00000243914*: DJ579F20.2 (similar to	4.00E−03	2.06
408246	N55669	Hs. 333823	mitochondrial ribosomal protein L13	4.50E−05	2.06
410582	AW867197	Hs. 337561	hypothetical protein FLJ21616	1.15E−05	2.05
411495	AP000693	Hs. 70359	KIAA0136 protein	5.38E−02	2.05
412059	AA317962	Hs. 249721	ESTs, Moderately similar to PC4259 ferri	6.72E−02	2.05
414548	AW937036	Hs. 183506	hypothetical protein FLJ14213	3.29E−04	2.05
433735	AA608955	Hs. 109653	ESTs	3.14E−02	2.05
441872	BE567100	Hs. 154938	hypothetical protein MDS025	2.04E−05	2.05
448920	AW408009	Hs. 22580	alkylglycerone phosphate synthase	5.92E−03	2.05
448980	AL137527	Hs. 289038	hypothetical protein MGC4126	5.43E−03	2.05
453078	AF053551	Hs. 31584	metaxin 2	7.28E−03	2.05
453574	AI767947	Hs. 50841	ESTs	2.63E−02	2.05
410664	NM_006033	Hs. 65370	lipase, endothelial	7.31E−03	2.05
436856	AI469355	Hs. 127310	ESTs	2.87E−06	2.05
408483	AA464836	Hs. 291079	ESTs, Weakly similar to T27173 hypotheti	4.24E−05	2.05
444775	AI040384	Hs. 19102	ESTs, Weakly similar to organic anion tr	6.08E−05	2.04
423996	AF205071	Hs. 137425	solute carrier family 21 (organic anion	7.84E−02	2.04
451334	AI122691	Hs. 13268	ESTs	9.76E−04	2.04
418504	BE159718	Hs. 85335	Homo sapiens mRNA; cDNA DKFZp564D1462 (f	8.16E−05	2.04
457830	BE147896	Hs. 14662	ESTs	7.61E−03	2.04
408194	AA601038	Hs. 191797	ESTs, Weakly similar to S65657 alpha-1C-	4.72E−02	2.04
428706	AA432030	Hs. 265827	interferon, alpha-inducible protein (clo	2.68E−06	2.04
435841	R28522	Hs. 186937	ESTs	8.82E−04	2.03
429586	T73510	Hs. 209153	angiopoietin-like 3	1.29E−04	2.03
453173	AB007902	Hs. 32168	KIAA0442 protein	5.73E−05	2.03
415662	AW972481	Hs. 170610	ESTs, Highly similar to G01887 MEK kinas	2.02E−04	2.03
407879	AA045464	Hs. 6557	zinc finger protein 161	1.89E−02	2.02
417303	NM_001698	Hs. 81886	AU RNA-binding protein/enoyl-Coenzyme A	2.02E−03	2.02
429857	AF089897	Hs. 294030	topoisomerase-related function protein 4	8.03E−05	2.02
432886	BE159028	Hs. 279704	chromatin accessibility complex 1	7.38E−02	2.02
432960	AW150945	Hs. 8739	ESTs	1.51E−02	2.02
436797	AA731491	Hs. 334477	hypothetical protein MGC14879	3.73E−05	2.02
439564	W77911	Hs. 110006	ESTs	5.56E−02	2.02
449845	AW971183	Hs. 6019	DnaJ (Hsp40) homolog, subfamily C, membe	6.20E−04	2.02
419426	AI214690	Hs. 346257	aldo-keto reductase family 1, member B1	3.19E−03	2.02
424571	BE379766		polymerase (RNA) II (DNA directed) polyp	1.24E−06	2.02
441965	AA972712	Hs. 269737	ESTs	4.77E−03	2.02
421456	AW579842	Hs. 104557	hypothetical protein FLJ10697	1.96E−02	2.02
408395	BE072425	Hs. 44579	hypothetical protein FLJ20199	5.59E−04	2.02
427561	AI123333	Hs. 134191	ESTs	2.67E−06	2.02
411678	AI907114	Hs. 71465	squalene epoxidase	3.03E−02	2.02
448873	NM_003677	Hs. 22393	density-regulated protein	1.24E−02	2.02
420747	BE294407	Hs. 99910	phosphofructokinase, platelet	9.75E−03	2.02
430213	AW993446	Hs. 235445	hypothetical protein FLJ21313	4.42E−02	2.02
417971	Y08991	Hs. 83050	phosphoinositide-3-kinase, regulatory su	1.19E−02	2.01
424247	X14008	Hs. 234734	lysozyme (renal amyloidosis)	3.06E−03	2.01
404240			NM_018950*: Homo sapiens major histocompat	2.45E−05	2.01
400906			C18000324: gi|12229928|sp|Q9PTW9|PSA7_CAR	6.69E−03	2.01
422431	AI769410	Hs. 221461	ESTs	4.37E−03	2.01
444654	AV650572	Hs. 23440	KIAA1105 protein	1.59E−03	2.01
418248	NM_005000	Hs. 83916	NM_005000*: Homo sapiens NADH dehydrogena	8.07E−02	2.01
437830	AB020658	Hs. 5867	KIAA0851 protein; suppressor of actin 1	6.71E−03	2.01
438023	AF204883	Hs. 6048	FEM-1 (C. elegans) homolog b	2.43E−03	2.01
448770	AA326683	Hs. 21992	likely ortholog of mouse variant polyade	8.37E−04	2.00
416430	H60487	Hs. 159440	bile acid Coenzyme A: amino acid N-acylt	1.52E−03	2.00
421360	AA297012	Hs. 103839	erythrocyte membrane protein band 4.1-li	2.02E−03	2.00
418838	AW385224	Hs. 35198	ectonucleotide pyrophosphatase/phosphodi	5.60E−06	2.00
425145	BE242802	Hs. 154797	KIAA0090 protein	3.19E−03	2.00
437672	AW748265	Hs. 5741	flavohemoprotein b5?	1.19E−03	2.00
439898	AW505514	Hs. 209561	KIAA1715 protein	3.19E−03	2.00
444743	AA045648	Hs. 301957	nudix (nucleoside diphosphate linked moi	8.32E−02	2.00
445790	AV655170	Hs. 49015	chromosome 21 open reading frame 35	2.55E−03	2.00
451141	AW772713	Hs. 247186	ESTs	2.04E−02	2.00
454105	NM_001259	Hs. 38481	cyclin-dependent kinase 6	3.82E−03	2.00
458389	H70284	Hs. 160152	ESTs, Weakly similar to FPHU alpha-fetop	4.50E−05	2.00
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of Hep C+ Liver over Trimean of Hep C− liver Ratio

[0355]

TABLE 7B
	CAT
Pkey	Number	Accession
442048	750422_1	AW340495 AI984319 AA974603
451752	10408_5	AB032997 AI141678 AW978722 BE467119 AI761408 BF727385 AW237035
		AI934521 BF436248 AI479668 Z40632 AA832081 AW295901
		BF057835 BE465977 AI621269 BE465983 BF756369 N74056 AI817896 AA716567 AA934774
		H62600 H09497 BF943762 BE395335
		BE883333
421057	265006_1	BE222349 AA830545 BF224127 H99396 N81017 N81016 AI525205 T58283
407644	27910_1	D16815 AL563603 BG399756 AI935028 N41813 L31785 AL529953 AA428473
		AA401262 BF802576 AA373868 BE886120 BM479352 T28309
		N57167 BI551531 BG037160
444314	1027984_1	AW749625 AW749626 AW749644 AI140497
432954	2159612_1	AI076345 AI887648 AA572691
433586	32908_1	BC011194 AW517087 AA601054 T85512
419175	35068_1	AB018322 BC012480 BI524873 AW665554 AI934469 AI479916 BF096179 BF096162
		BF096132 AA744972 AI951988 AI858339 BE076331
		AA886998 AI570585 AI916688 AI678811 AI693109 AI308135 AA669046 AA961064
		AI018062 H80618 BE221942 R52609 AI915164 AA365626
		Z44671 BI052776 BF882486 BG286184 AI589558 AA931663 AA534979 AI275392
		AI273455 R52553 AA829920 H80652 AA360728 F10618
		AW953666 AW176773 H85527 AA765570 AA081927 BF093262 BG743753
		AL037576 AA534314 BE814964 BE973713 N49493 BE006634
		BE006630 AW270037 AA234765 AI334004 BF057179 AI857450 AI341191
		AI434143 AI917449 AW517207 AA255424 AW008334 AA847572
		AA994211 AA861901 AA581873 AI580157 AI364363 AW242357 AW235291
		N55645 AA319869 R36911 AA256551 AW044188 AI203159
		N49403 F02090 AI187299 AI609644 Z40516 AW952314
400247	2764_1	BC022339 BC009610 BC010537 X79805 NM_006713 U12979 BM467814 BM450743
		AU132951 AU137129 BG493425 AV758819 BG708412
		BG705885 BG702217 AV716638 BG777009 BI545689 BI552153 BM476712
		BG770858 BG527656 BG528277 BG391388 AV716861 BI602926
		BG290073 BI667399 BM451469 BI667173 BI602139 BG532171 BI669216
		BI544727 BG721852 AV716503 AV701327 BM090738 BI492000
		AI308856 BI544904 AL599813 AV715829 AV716505 AV714587 AV717902
		BF668072 AV716385 BI461927 BM090954 AV717826 BG503676
		AV647719 BG501392 BG428433 BE895629 BM313117 AW021050 BG435032
		BM152910 AA313503 AA872377 BG574714 AV712054
		AV732696 AA252476 AV712759 AL599643 BE790872 BG654930 W73337
		AW675377 AV760376 AV725139 AV716379 AA887165 BE830003
		AW023796 AL599291 AI902948 BG944042 F00781 AA352483 BG217897
		N33888 AW581924 BG654730 D31410 AA353088 D31288
		AA295029 H95170 BE935104 AU139980 BG772963 BG776470 BG532512
		BG105449 BI545421 AV715456 AW386083 BG699714 AL535832
		AL514940 BG190861 BG210593 AW999254 H95138 AA353863 BE764809
		N50375 BE091363 BG701255 BI860846 BI832485 BG168150
		BG028647 BE546301 BG900321 BI909737 BG702363 BG614141 BG611137
		BG700121 BF031492 N85802 AV715940 N51590 BG993478
		BE172016 AW893622
436024	138548_1	AI800041 AA703553 AA984529
443547	137089_2	AV645808 AA701657 AW271273 AI796734 AI472316 AI017531 AI061178 BF109096
		AA548964 N83805 AA131648 AA156589 BE708349
		AW952494 D30877 AV684717 Z24837 F00167 BF576150 T63841 R78995 N87474
416475	1972665_1	R02750 H58072 T70298 BF367306 R02749 T80873
408096	9330_1	U61981 NM_002439 J04810 BC004177 BC011817 BC017273 BG876463
		BG876469 BG876468 NM_000791 BC009634 BE741138 AI830697
		AW572941 AA489055 AA463881 AI186480 AI803332 AA129465 AA749344 AW572255
		AA447680 AI184392 H94631 BC000192 BC003584
		J00140 V00507 AL525560 BG532440 AU130196 AU130635 BG699143 BE295309
		BG771877 BG497327 AV714645 BE397236 BI458721
		AU127142 BE252613 AW575796 BG328723 BE250809 BI759776 BM051687 AL040147
		AA314334 BE780925 AU099092 T29009 BE250162
		AU139133 AA421716 H99382 BG188773 BE514324 BG199292 BG217128 BG188772
		BG202122 N44579 BE250719 AW473270 AA382889
		AU157895 BF907195 J00146 BM475776 AA974401 BF514204 BE743689 AW993728
		AW364498 BE514508 BG195205 AW069265 BF881506
		BF928376 BE874450 AI909030 AW051136 AL514516 AW970133 AL514515 AA701106
		AA516401 AA578546 BF792184 BE566555
442679	31783_3	BG621493 BI056706 BG496376 R53718 W65356 R79357 BG434247
		AA357769 AW978686 BG573200 BF132113 BF086709 AA366938
		D79234 BG494628 AA156754 BG434311 AW978683 AW273417 BM054662 AI799886
		AI433351 AI160798 AI433742 BF056186 AI281606
		AW015046 AI439585 AI245530 AI078267 AA807170 AA837395 W61252 AA831085
		AA287371 AW768354 AA890606 AI302539 AI708575
		AI673031 AI242260 AW514069 AA283958 AA825452 AI371234 AA425696 AA453422
		AA827697 R23653 D20240 AA772517 H13802 R66972
		R79360 R27351 F03379 AA031952 N69504 R33143 R79358 R39136 R38800
		R15089 R52937 R37502 H01021 R33634 R46551 Z40404
		BG291052 BG570357 AW391046 BG496872 H23558
418876	121279_1	AA740616 AA654854 AA229923
434210	54921_1	AK057015 AI026834 BE857936 AA149091 AI742972 AW439172 AI253168
		AA255613 BF513175 AI005006 T03406 AW338149 AA836442
		AA420530 R88566 AI611672 AA433916 AA442855 BF063008 AA812568 AI889706
		AA715313 AA768539 AA767620 AA665471 AA404380
		AA665612 BF056442 AA706388 AI650676 AA627448 AI141769 H78227 AW901852
		H78221 BE701982 BF689273 AA397464 N33072 R60218
		AW968247 H14833 AA768305 AA043348 R56470 BF739832 R51827 AI474963
		BG494574 AA149090 BF238154 AI802210 BE000129
		BF734513 R41964 H21055 R85253 R17705 R40844 BF790218 BG388356
		BF003037 AA703138 AA377348 W24822
400133	2368_1	NM_005648 BC013809 L34587 BF103775 BG702618 BG716553
		BI667090 BG505863 BF983483 BG718195 BI857891 BG501016 BM043599
		AL521812 BG705730 BI495545 BI495546 BF112248 BM023182 BM023123 AI075173 AW051799
		BF058224 BI324885 BF436008 AA398446
		BG822375 BM019558 BM023382 BG164174 N56909 BI467064 BM023464 AI207475
		BM311415 BG758430 BG758807 AI934826 N90351
		BG422026 BE910312 AI027778 AI081950 AI360890 BM009115 AI191829 BG759697
		AI138728 AA399403 AI355589 AI336427 AA868702
		AA393660 AA025127 BG027630 AA962774 AA631224 BG940967 BE791087 AA573315
		W81685 AA393525 BG944103 AI339125 AI149864
		AA977655 N90314 BE612839 BG491847 AI129091 AA461234 AA781198 AA759256
		AA888954 AA975844 AI184099 AI018025 AA398363
		AI003331 AI193380 AA626020 AI244476 AI601114 AW135664 AI206607 AW263599
		AA813219 AI684453 AA878626 AA772222 AI085496
		AI630226 BG940966 AI022010 AA770649 AA887624 AA491739 AA974295 BG530040
		AA037091 AA019912 BI160457 H64512 BG503896
413509	1518543_1	BE145433 BE145419
429588	1396089_1	AI092511 AI080271 AA455177 AI381859 AI381721
407347	810943_1	T23514 AI655785
439195	21979_1	AF086037 H89360 H89546
413007	1343540_1	BE046662 BE046697 BE046655
437834	294580_1	BG110129 AW749287 BE535498 AW749299 AW749293 AW749302 AW749298
		AW749291 AW749294 AW749289 AW749288 AW749296
		AA769294 AW749297 AW749295 AW749292 BE002573
427384	1367813_1	AA401778 R92652 T82854
432600	114582_1	AW973464 AI821831 AI821085 AA640756 AA657438 AA554802 AA650339
411605	10026_3	BG256892 H10532 N46614 R52610 AW977696 BM460488 W56819 BI042183 BG977498
		BE767451 BF870009 BG477472 R61137 R14274
		R20259 R09686 BI838226 BF034269 AA429173 BE741829 AW867495 AI123683
		AW006831 BE831162 AW452753 AV742717 W86152
		BF115102 AI633815 BF921562 AA094230 BE092587 W86151 AA526153 AI672156
		BF914496 R12579 BF852352 AA699780 T57386
		BF903022 R09933 AA678298
454067	98108_1	AI809849 AW241782 AA041455
456034	685586_1	AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945
432676	3503_22	AI187366 AA618478 AA558869
428342	6712_1	AK056315 AI015524 AA724079 BI713619 AI377728 AW293682 AI928140 AI092404
		AI085630 AA731340 BM469629 AW968804 AA425658
		AA769094 BF446026 AW118719 AI332765 AW500888 AW576556 AI859571
		AW499664 AW614573 AW629495 AW505314 W74704 AI356361
		AI923640 AW070509 AI521500 AL042095 AA609309 AA761319 AI381489 H45700
		AA761333 AW265424 AA909524 AA635311 AA649040
		AI392620 Z40708 AI985564 AW263513 AA913892 AI693486 AW263502 AI806164
		AW291137 BI061872 BI059498 AA134476 AW084888
		AA036967 AW370823 T55263 BI002756 AA489664 BF827261 W74741 BF963166
449001	1968002_1	AI654836 AI619957 H51659 R99472 R99473
411656	1095889_1	AW855650 AW855576 AW855577 AW855642 AW855578 AW855621 BG950916
		BG950923 AW855619 AW855624
434987	121985_1	AW975114 AI096634 AI767001 AA658364 AW517542
434280	1474904_1	BE005398 AA628622 AA994155
414405	112689_1	AL047596 AA393792 AI670731 AI037957 AW874364 AI038137 N62286 AI241379 BE501096
		AW090696 AI927369 AI669226 AI369437
		AI371075 AW612409 AI686711 AI183289 AA477717 AI076122 AA635190 AA700984
		AA781508 D81020 BF575223 AI356183 D79312
		AI375558 H61111 BG283489 BE090666 BE090664 BE090662 H26545
407218	34845_3	AK026094 AK024519 BG697329 BI768179 BG680257
		BE275725 BF945273 AW674728 H62658 BG951138 AA326011 AW993688 W67819
		BI036861 AA524981 N28558 AW799454 BG286696 BG434856 AA317171 BE548299
		BF987870 H12577 H87965 BE867572 BG107813
		BE747295 AL118999 T95439 AA363896 H16012 H27146 H41959 R63045 N49563
		AA032167 BI917617 H02466 AA207162 AA081975
		BG749301 T11901 AA091553 BG945206 AA095473 BM172375
407992	101407_1	AI458141 AI743200 AW418811
452194	90339_1	AI694413 AW994700 AI912946 N73548 AI082035 AW271652 W24189 W24182 AI719718
		AA024658 AW810120 AW015394 T79755 AA988043
		AI709339
427213	507972_1	AW007211 BE467259 AA960991 AA399252
433075	78_6	X98248 NM_002959 AU127082 AU143346 BE327147 AI168442 AA426361 BF056336
		AA418378 AI470560 AI365213 BI032745 BI032986
		AA969895 AA233278 AW291971 AA418326 AI198417 AI337018 BI032747 AA888000
		AU099083 AU129681 AL036861 AA418275 BF887436
		BF767448 AA232975 BI094065 BI859449 AL079651 BF877391 AW902319 BF878798
		BG281450 AA418268 BG770672 BE890328 BI520437
		BE387505 AW375004 BI020046 BI033747 BF800905 BF869732 N99710 BF905459
		BE715637 BE746496 BF918537 BF751392 BF751390
		BF369123 BG949840 AA984366 H85743 AW593418 AI990196 T92267 AA018359
		H38111 BM050097 BF692315 AW805907 AI547305
		AA631091 BF845219 BG949806 T92310 BE277220
418304	1093209_1	BE883520 BI057842 AA215702 AA215703 AA368006 BE006876 BE066555
438021	45849_1	AY043361 NM_007013 AL136739 U96113 AL049041 AI750898 AA054855 BF887778
		BF333173 BI061338 BC015380 BG569062 BM090890
		AI769300 BE466554 AI091728 AI800660 AA832035 AI342285 AI750899 H66486
		AA455942 H20821 AI187877 AI417440 AW198099 AI245158
		T91227 AI373068 AW194829 AA680229 BG291204 AW885601 BF380168 D82380
		D82098 BF885552 AL050082 BE552267 AI458088
		AW137654 BM014715 AA418921 AI159868 AA845398 AI743920 AI159888
		AI653531 AA843952 AI799752 AI360957 R67562 BF445478
		AA854844 AA552895 C21152 BE614563 BI260650 AU155187 AW169673 AI915801 N29619
		AA435618 AI361252 AI424627 AI219018 R67514
		AA548141 AI246669 AA156867 R67561 R67513 AW263860 AA089478 AV653790
		AA354846 BI560015 AW794547 R52020 H18923 R67555
		AI302490 AL582101 AI871884 AW029104 AI582326 AV688960 AL040820
		AI804339 T57931 R67554 AA418232 AA393281 BE076206
		AW189435 AW979344 AW953494 BF056797 AA310720 N64062 W92065 AI761704
		AA418824 H89156 H88930 W92048 AV733096 AW007773
		AI745541 BE504125 AW243111 AI201009 AI187909 R44411 AI795988
		BF222383 R29593 AA156952 BF029856
432689	11004_5	AL563022 BC011883 AI625937 BE302243 AI240793 AI886651
		AL134289 AA877735 AI284399 H80252 AI753853 AA564328 AI075230
		AA657859 AI269462 F09349 AA653028 T71751 T71812 R58128 AI890218 T71659
410099	16732_1	AK055674 AW965247 AV751598 AA290926 R53043 AA331387 AK056148 BI917678 BG819395
		BG911971 BG820167 AI174254 AA348720
		AA364503 BG714279 AW893230 AA081774 H24222 AV727176 BF875715 AA081630
		BE000834 AA334880 AL563737 BG029709 W52882
		AI439658 BE551237 AA283724 BF109530 AI457096 AI805992 BE467736 AA693467
		AI697593 AI887863 AI167419 AW901980 AW901768
		BE702179 AA484549 T23811 BE327043 AA716027 AA917004 AA167714 BF339675
		AA084618 AI418634 T31586 AA436630 AI366472
		AA706191 AI422304 AI204899 AI041169 AA211402 AW827081 AA788593 T32736
		AI767935 AA747914 T03534 AW959843 AL119527
		BE327037 AW901982 AW993370 AW901977 AW902071 W60090 N79906 D52685 T07735
		BE702069 BE702172 T08671 BE767121 BE767117
		BE767113
433891	647290_1	AW182329 AA613792 T05304 AW858385
425757	1228540_1	AW963347 AA371863 AA363171
400281	9758_4	BE564506 Z47727 BF028489 BI597545 AA152273 AA730753
		W07504 M406507 AA316220 AA424683 N35844 N72473 AA442109 W01788
		AA747605 AA235894 N41438 AA382786 AI906934 AI906935 BF091197 N85572 N75678
		AV758098 BE719745 BE719744 BE719735
413645	1234345_1	AA130992 AW969537 AA503835
423886	887218_1	AW950497 AA332098 AW950499
408731	11725_2	AF305826 BE350971 AI765355 AW172600 AI310231 BM271766 AI547292 AW612019
		AI674617 AW138666 AI147629 AI147620 BF857810
		BF886300 BF885952 BF886303 BF885956 BG565497 BE670834 AA114025 BF886396 BF886928 AV750861 D62864
443126	1057340_1	AI033503 AW801770 AW801782
448219	22785_8	AW577769 BE076308 T98501 AW577775
418259	133853_1	BM310925 AA426110 BM310629 BF434286 AW015091 BF475996 AW118867
		BE675186 AI688568 AI453594 AW590589 AI652425 AI827969
		BF056946 AI802866 AI393380 AI476224 AW590639 AW136271 AI458252
		AI524726 AA843768 AA782158 AI336058 AI097532 AW451563
		AA459408 AA459633 AA418444 W23607 BG940150 AI493445 AW054729 AI221929 AI868744
		AA215405 AA766713 AA621546 BF928317
		BE464132 AI990909 AW271459 AI262061 AA215404 N74332 BG940151 BG952261 AA972115
		W96315 AA689586 R69057 BF766886
		BE769254 W05240
415023	37164_1	BG763540 BI115604 BG325282 AY007096 BE048206 BE048060 AA356949
		BG469451 BE267760 AI683752 AI702004 BE247172 T47611
		T47612 BE780300 AA932146 AA652369 AI784281 BM055020 BM023299 AI382709
		AA159351 BI262171 AI863355 AI674922 AI754389
		AW295190 BE673083 AW469497 AI949042 AW131720 AI990060 AI623178 BE673420
		AI863364 AA620354 BF431793 AI056058 AI056059
		BI258269 BI823911 BG482172 BI261556 BI519838
412634	131633_1	U55984 AA195883 AA447957 AA393452 AA384799 AW958952 W68044
		AA197345 AI241933 R59505 W67965 AA826474 AI336006 AA931733
		AW025414 AI769180 AI355738 AI860952 AA907417 AW408679 AA453139 AA938346 AI279697
		AA121899 AA400768 AI559827 AA448889
		N62400 AW236656 AA904207 W79380 R59504
419970	13569_1	AK055270 BE348291 AI190289 AW612022 AI269506 AI266578
		AI269675 AW271406 BE879851 BF574163 BI497126 AW903775 BI917368
		AW150900 BF244813 H79201
420985	455_7	X94703 NM_004249 AL521205 BF886672 N46403 T87420 Z36855 BF934259
		BI549507 BG899191 BI517479 BI818431 H39666
456984	29289_2	W28684 AW959164 AI909150 AW750651 BF055016 AW750639 AI909163 AA358374
		AV753402 AW968411 BF196253 AI697716 AI656043
		AW138212 AU146192 AI582306 AI814242 BF036992 AA723154 AW301605 AI378151
		AI680949 AL589221 AW304035 AA984657 AI290310
		AI668884 BG149396 AI537796 AA995333 AA402863 AA416859 AI300148 AA889348
		BE674396 AA740711 AI041113 AA723177 AW976742
		BF951876 AI909164 AI909181 H08832 R80981 W28685
		W28701 H18426 R80781 AW842470
423828	886732_1	AW962569 AA331536 AA331754 AW962568
411777	1104614_1	BE067593 H49900 BF331057 BF331045 BF331063 BE067552 BF331011
		BE067819 BF331039 BE067694 AW861997 BF331052 BF331005 BE067800 BE067714
421828	207_22	AW891965 AW604749 BE080872 R15559 BE177623 AW883520 AW945343
		AI246167 T07082 AW805679 W96278 AA135796 W32615
		AW995418 AW801688 BE003837 AW801621 AW385721 AW385742 AW385714 AW604757 W87409
		AW604738 AW385757 AW580796
		AW801247 BE003239 BE003183 AA847112 AW580975 AW604760 AW385727 BE164590
		BE003090 AW362791 AW604759 AW866589
		AW604758 N44337 AI378548 AW890438 AA077172 AI288683 AA229639 AA091945
		AW945454 AA063629 AA702504 AW861938 AW894816
		AW580841 AA094372 T06399 AW885686 BE244086 BE005035 AW861913 AA551773
		AW858460 AW370926 AW754352 AW889695
		AW384408 AI907428 BE067491 AW861939 AA248197 AW381373 AW177325
		AW806879 AA935217 BE067498 BE083742 BE067470
		AW894935 BE082529 AI248811 BE179917 BE002200 AW607506 AW392889 AW894560
		AW381360 AI904206 AW863533 C00609 AW381372
		BE082530 AW898120 BE075323 AW392799 AW601420 AI695314 BE083790 AW858568
		AW945550 BE177153 AW970506 BE350419
		AI906919 AW360794 AI906917 AW885979 AW794240 AW945566 AI688683 AI688694
		AW009660 AW601421 AW360793 BE066524 BE083901
		AW369847 AW381871 AW935435 AW664582 AW877775 AW838449 BE180466 AW858501
		BE180464 AI371163 AA778231 AI174991
		BE011720 AW877776 AW877800 AW877795 T19900 AW866365 AW898099 BE011715
		BE167842 BE011718 BE011724 AW363639
		AW878658 AW878662 AW894887 BE082356 AW389211 AW804286 AW610312 AI904717
		AW610318 AW996909 AW610296 AW901923
		AW880003 AI762171 AW062582 AW368713 AW062593 AW176663 AW842064 AW842089
		AW842095 AI243049 AW902074 AW062592
		AW176664 AW751692 BE087703 AI907439 BE009686 BE172115 BE077030 AW608556
		AW835577 AI909628 BE077029 AW176241
		BE077552 BE160370 BE160288 AW835656 AW606765 AW606770 AW835678 AW606758
		AW606778 AI907484 BE172821 AW606768
		AW999517 AW844165 BE171738 AW751683 AW610493 BE177484 BE177487 AA090510
		AW844117 BE173367 AW999878 AI124870
		BE163472 AW841823 AW379762 AW893297 AI290296 BE089132 AA610287 AW176676
		AW607622 BE172639 AW893232 AA329629
		BE089008 BE178350 BE178214 BE063291 AW820236 AW999653 BE089486 BE173126
		BE171775 BE185787 AA558280 AI174840 AW999112
		BE218391 BE172734 BE178021 BE172738 BE173324 AW603494 AL036722 R38192
		R60905 H53721 H41052 AL037917 R37795 AW998972
		AA767189 AW044272 H50689 AA768399 AA767764 AI087888 H44202 BE222792
		N90597 W81396 N90615 AI935353 BE501168 F10945
		AW118215 AI970480 AI627641 AW236081 AA574090 AI627652 AI681913 AI759983
		N69591 N69276 BE467722 AW392780 BE172467 H92861
		AI524921 F02989 Z39328 F02705 F01414 T88678 AI215165 H87220 AW374781
452279	11990_1	AF392454 AK023074 AI884890 AI814455 AW966220 BF736545 AA026021 AA286843
		AA251918 BG197710 AA026294 AA337356 BC010422
		AK023226 NM_022776 BM459496 AA769310 AI826460 AU153650 AU160375 AW166211 AW292992
		BF433538 AI823888 AI684798 AI655985
		AW770982 AI400454 AI276257 AA639510 AI689818 AW772604 AA807639 AU130298
		AU132028 BF900889 BF904822 AY007102 AU143256
		BG621460 AA829630 AI864665 AI084922 AA025234 AI360060 AA766554 AA026295
		AA825817 AA251762 BE180751 BM464530 AV715833
		AA779447 AI452519 AW418525 AA435643 D25894 AA435651 AA286844 N64369
		AI702262 BG288063 BE170545 BM466232 BE299160
		AA169573 AL567428 BF217285 BE967276
400189	2140_1	Y08200 NM_004581 BC003093 BE733834 BI753321 BG773890
		BF091906 BI917541 AI023762 AA587230 BF435086 AI264262 AI687392
		AI810536 AW589886 AI244419 AA749261 AA535435 AW205689 AI765770 AI765431
		C02465 AW305347 AI818456 AA322111 AW381845
		AW381829 AV749407 AA811636 AU159893 AA603065 AA652542 AI468678 R49616
		AW381863 BE389867 BE182387 BF087771 AA527551
		AA134051 AA831504 AA134052 AI871759 AW089048 BI913532 AA367709 BG828155 BF093014
442961	60316_2	BE966247 BE220885 BE467384 BE350135 BE672094 AI811582 AW665254
		AA772731 AI283601 AA417067 AW197746 AI868357 AI792143
		AA931120 AI758506 AA843761 BE737582 AW379586 N38812 BG567321 H13257
422150	782_1	BI086421 BF059136 AW003898 BF446659 AI632891 AI628067 AI703179
		AI961149 BF111022 AW614154 BE674215 AA687350 AA779426
		BF591963 AW243344 AI356530 AI492508 AI694049 AI090422 AA465307 AI273387 BE674625
		AW271971 AA969153 AW468593 AA984014
		AI817491 AA970258 AI914450 AI018697 AW577591 AW577616 AA382101 AW954455
		AI867266 AI707995 AI337384 BF208406 BF037100
		BF223433 BF195517 BE673984 BF224124 BE813387 BG036579 BI553906 AA304995
		AW361269 AW754160 AW361276 AW361271 AI867118
		AW805555 AW361284 AW954458 AW958551 BG681507 H79011 AW205696 AW134957
		AA747667 AW753296 BF939060 AW958549
		BF910827 BG573750 BG168639
436262	2276_7	BG028838 AL597498 AW938817 AA707425 BE089516 BE175202
418733	18099_4	BM473699 N33854 N35083 BE090367 AI306129 AA911920 AA633160 AI302415 AA609954
		AI365203 AA911919 AW995271 AA234587
		BF996091 AW956344 AW389533 R60133
437151	282041_1	AA745618 AW606658 AA745616 AW805449 BF897789
421272	64950_1	BG819964 R87567 BF062036 BF062044 AW014470 BG057316 AI810506 BE466071 R88291
		AA704157 C15898 C15173 AA286825 BF594141
		R84605 H85515
430068	1177709_2	AA947566
432474	1237469_1	AW973273 AA584042 AA548798
446851	9025_1	AL530311 AI929658 BE504156 AW160973 AW007332 BE327718 AI268061 BE219811
		AW162577 AW139586 AI142112 AI929817 BE348817
		AI281962 AI694916 AI694425 AA476502 AA911355 AI867757 AL522996 AK025716 BI966713
		AI823741 BF435119 AI740654 AI377656
		AI380387 AW612765 AI190300 AI080728 AI425090 AA927634 AI911024 AA826114 AA693577
		AI003964 AA680381 AI203302 AI004628
		N75950 AI497985 AI918293 AW168793 AA909369 AA884574 AI191792 AI868413 AI458050
		AA233857 BM462189 W72450 BG775793
		AF064843 AI458158 AA568445 AI802171 AA604222 AI393739 BE044639 AI351150 R43836
		AL523063 AW960720 AA621125 AA587562
		AA810864 T86692 AA007682 AA055564 AL523983 AA007681 N39693 W04974 AA449174
		T86786 W76299 R54146
426221	MH1660_70	AF186377 U32581 AA776981 AW473826 AU127861 N24261 W31964 BE702576 BM455665
		BF371317 BF371314 BF371305 BF371302
441969	2681178_1	AI733449 AI733386 AA972780 AA988876 AI791798 AI791748
459436	880261_1	AI908449 AA323121
425284	3834_5	BM476120 BE672181 AI697653 AA938187 AI280879 AW340123 AI912727 AI081775
		AI089556 AI191349 AI871604 AI631607 AI890800
		AI701917 AW771624 AA663041 AI991576 AI160622 AA771763 BE089784 BE089788 AI222942 AW418516
		AA329211 AI095736 BE550294
		AA738345 BE218683 BE670548 BG149505 BF061776 D19821 BE005786 BE178892
		BE005728 BF841237 BE005648 R27634
411617	11546_6	BF037031 AV752097 AL602446 AI004475 AA312353 N94870 N28394 AA179069
		BF746111 AA351029 AA096257 AA247994 BM313163
		AW364986 R25275 AA837053 AA191277 AA809755 AA094345 BM152038
		BF514649 BM151933 BE769272
416048	1904153_1	H16413 H16268 H19416 Z43074
414404	19538_5	BG036308 AW813969 AW579686 BE147476 AW813871 BE147474 BE147589
		BE147582 AA767716 AW813960 AW813958 BE147583
		AW813608 AW813612 AW813965 AW813954 BE706154 BF843546 AW813870 BE147801
		AW813962 R80512 BG681408 AA344564
		AW370224 BG614838 AW582118 AW582114 AW370227 W16712 BF209670 BG117739
		BE762802 BE087964 BE888647 R89145 BF342601
		BI752591 BG435038 AA166732 N79515 BF541709 N79567 BG503029
437838	2512601_1	AI308202 AI307229 AA769348
434384	132928_1	M631910 AI928421 AA687629
446830	41421_1	BC020595 BI488430 BG168023 BE179030 AW294203 BF849776 AA459064 AI917452
		AW403072 W27419 BF914568 BF798468 AW370558
		T35055 AW370623 AA399232 AA214221 AW802987 BF902228 AW370622 BF819597
		AW370567 BF914313 AW954040 BF060706 AA194237
		T25074 C01285 BI489433
447657	2957064_1	AI953011 AI953026 AI936839 AI418034
408138	14592_2	AW374043 BG568336 AW374058 AW961372 AA328028 BF438186 AI268678 AV724415
		BG029720 AA725816 AI926580 BM310209 AA968470
		BF430989 AI185775 AW002091 AI969941 AI718705 AI360440 AW008856 AA862294 AA625752
		AI610753 AA471020 AA723203 AL044614
		D80637 H77377 AA745928 AA743114 W25004 AI127139 AA953939 AA908426 AI800072 AI417080
		AW874111 AI439293 AI370639 AI277179
		AA883338 AA469058 AI200997 W94913 AA047544 W91966 W69102 W84439
		W52870 W67288 W69103 H98077 AA111874 AI913850
		AA535740 N92824 AA973639 W68358 BE170126 T81345 N50135 AI567418 W67220 BF437728
414279	5766_2	BG430995 R53271 Z33587 BE073129 BE073137 R52586 AA137263
		BG031848 AI983837 AI434776 AI767302 AW236107 AI676204 AI420077
		AA282786 AI498342 BM310542 BM310847 AI089287 AA398984 AI129279 H79114
		BF431053 N53529 AI741845 AI333439 AI674468
		AA137264 AI624731 AA399623 AI968243 AI863637 AW769997 AA618148 AI220925
		BI492628 R52535 AI474904 H72893 D51042 AI744688
		AW021691 N38931 N24944 AI537404 AW242437 H99461 Z41183 R52617 BF448803 AI979148
		R44190 R45431 BG436113 AF236691 H72493
		AA482849 BF219145 AA625451 BM312732 AA282874 N33821 AW970080 BE780127 R23405 R25093
416272	3292291_1	AA178882 AA178897 AA179898
425303	1223924_1	AW958427 AA354785 AA354792
438980	917280_1	AW502384 AA828822 AI982587
452480	3144986_1	AI903574 AI903572 AI903526 AI903571
456721	17316_2	AK027110 AI823404 AI311783 AA552514 AI936370 BF435170 AW468427
		AA533356 AA779031 AA318991 AA614088 BF868935 R67736
		BG007848 AA720986
423983	888204_1	AA333365 AA552870 AA333261
438141	1173217_1	AA778849 AW946871 AW946782 AW946955
438041	2523562_1	AI394551 AA812658 AA776285
416611	10454_1	BC010161 BG576118 AI708321 AI478300 BF111611 AA568308 AI984473
		AI453629 BI495582 BI495581 AI983169 AI695792 AI695791
		AA181902 AI376993 AI472805 W26851 AI341559 BF735125
414496	1526_1	AK058006 BF724822 W65303 AW887764 AW023806 Z25353 AW022095 AA730973
		W00417 W73819 BF982096 AI927669 AW188021
		AW770478 AI913512 AA604358 AI697341 AI691028 AI338392 AI079403 H97538 AI144448
		AI253102 AI051402 AI335900 AI868132 N28900
		H98465 AF268386 AI799915 AI819228 BE048413 AW304723 AI819923 BF223106 AA155907
		AW298079 BF055272 BF446804 BF197697
		W58588 BF197538 AA032180 AA992597 AW590254 AA027824 AI129369 AI131331 AI655843
		AA932907 AW104493 AI150615 BF110226
		AW172271 AI312659 AA057312 BE673669 AA722984 AW104985 AI129232 AI078648
		AI653086 AI703481 AW515897 AI352206 N67076
		AW297281 AI686162 AA029184 AI610743 AW772016 AI091778 W65401 AI687374
		AI218085 AI765158 AI018002 AI653068 AI335704
		AI520850 AW275228 AW275204 AI420247 AA975336 AI697042 AW182235 AA736386
		AI281682 AW169698 AW263325 BE645834 AI377438
		AI146706 AA613808 AA716538 BI496247 AA032248 AI698930 AI193399 N70026
		H86792 AA404489 W61267 BF447230 AA910805 AA150774
		AA621907 AA902526 AI827634 AW022037 BF059000 BI496246 BG577007
		BG571077 AA460779 AW816890 AW816893 AW816891
		AA029183 AA010295 H86850 T83320 BE160823 H12925 N40087 AA096372
		BE160847 AW816892 AW816889 AW816882 AW816868
		AW816941 AW816578 AW816940 AW816577 AI431628 AI828113 AA033677
		AA033654 AA452704 AA317582 AA346971 BF836584 H48669
		BI861605 BG925200 AA463277 H89048 AA155952 W03252 W01510 W00915 W58589
		AA164519 N24017 N24622 N27149 N70109 R43771
		AA010296 W84611 H98889 H88965 AW594424 AA034139 AA065223 N99696
		BG981481 N94371 AA767970 W47146 N70977 H05510 W61268
		T90796 AA164518 W47244 AA150883 AA034138 BF338483 F13671 H51317
		W72716 N21488 AI188071 AI370541 AI754442 AA148524
		AI749182 W95221 W92522 R20385
419200	9531_1	BF036043 AW190446 BG194731 AW662036 AI445021
		BE937550 AW818972 AW393132 AA834685 BF112058 AV721682 H16423 AI270167
		AI857345 AA937302 AW818444 BE929780 BG498678 BF155010 BI598271
		BI599811 BE161728 AW578737 AW753711 AW379707 AW381918
		BG506608 AW028637 AW994240 BF887392 BF790073 AW381624 AV727105
		BF439618 AA443174 AI018009 N42850 AW573242 AI417258
		AA463483 AI676131 AI167170 AA836627 AA443828 AW592922 AA235129
		AA730278 AW439062 AW474332 BI043239 AW474342 BG708553
		AW362423 BF090028 BE827256 R16550 R39478 R39479 R94368 BG540916
		BM314745 AA251087 D54231 D55274 BF085805 D31589
		AW966405 AW994425 D81879 BE093545 AW901107 AA383529 BI021552
		R56420 N39976 AA573281 H82595 AA234955 BE093539
		AW367006 BF358697 BF366318 AA663856 BE702099 BF035969 AI267384
		AI267232 BE348320 AA621574 AA861212 BF083343 BF083341
		AV745131 D53074 AW954476 AW954472 AA376836 AV724531 D53063 C14928
		AA093287 AA062638 BG483558 BE940050 AA765954
		T70171 BE938775 BE940057 D53502 AW373300 AL118798 BM128728 AA193411
		AW444709 AW952455 AI887612 BF431948 BI496876
		AI264159 BM128481 AI624657 AI689301 AI969467 AA861685 AA251595
		AA625761 AA872090 AI826790 AA328366 BE827416 R75951
		D56918 R68122 BE827384 AL118797 AI184164 AA164411 BI495332 BE858113
		AI863860 H00660 T69849 AW780389 C14667 BE934995
		BI018652 R92801 AA164410 H00752 AW373305 AW373299 AW373302
421297	16064_1	AB033081 AK074324 AW450283 BM128413 BE550945 BE670081 BE674137 AI298087
		N30050 BF110807 N30072 AI288098 N30068
		AW861931 AW858575 AI363734 AK025483 BF882045 BM128581 AW771330 BE669540 NM_016376
		AB037360 AA399607 R94364 BE514643
		BG684040 BG759578 T83725 AW858561 AW858524 H65293 AW754345 AK025960
		BM477612 BE071291 BF087041 BG995615 BE071350
		AI917153 AA436381 BE815318 AK025717 BE857148 AI741138 AW027718 BI789162
		AI492263 AI690072 AI420179 BI789249 AI637804
		AW957459 BF222458 AI094328 AW510893 AW295994 AI760430 BE464934 BE220458
		AI042022 AI653315 BM128472 AW337972 AW515837
		AI669489 AW664176 AI768730 AW271660 T16381 AI823834 AJ346113 AI242353
		BF437578 AI273673 AW513498 AI797424 AI674242
		AI277236 AW731756 AA373089 AW207589 AW467879 AL550999 N30075 BE883669
		BF155456 AI423079 R60281 T16974 BG676892
		BF927070 BI962758 BE811485 BE811591 BE811702 BE811600 BE811483 BE811533
		BF927061 BG008257 BF873368 AL574815 BF946447
		H70934 BF939868 BF378761 BE082381 BG984527 AA244447 BG983567 AW885571
		AW293182 AW885607 AA811057 AA610310 AI434406
		AA514352 H71020 BF740351 BE814815 N66648 AA737686 AI025403 AA255490
		N26754 AI094233 AA629548 AA716234 BF343632
		AW363633 H62663 N40757 N55959 AW858569 AW604731 N40773 N40777 T83895
		AI905899 BG007487 BF820299 R60231 R60787
		AA456130 AW383736 BF087045 BG995619
439046	2580645_1	AA829660 AI687296 AA947354
440638	371165_1	BG009500 AI376551 AA897445 T87714
434747	117643 _1	AW976537 AI033582 AA837085 AA745261 AA648395
453929	97058_1	AA045461 AA284145 AI494193 AI469576 AV700262 BF222563 AW190054 AI263834 AA040074 AA045137
455834	1518503_1	BE145364 BE145429 BE145418
421921	100_2	BC011987 AA976353 AA858127 AI370017 AW150562 N22469 AI823318 T39763 AW594422
		T39771 T39737 T39788 AA857399 T39764
		T39745 NM_012456 AF150089 BI835353 BG683054 BM021899 AI693046
		AI350334 AA609007 AA405045 AA412628 AW175775 AA035114
		BE729995 AV755393 AW027107 AI500393 H83363 F27315 BI966096 BG338889 BF342663
		AI097243 BE047615 AA628513 AI004714
		AA147779 AA993774 AA670296 AA845320 AA908522 AI002166 W61055 BE349980
		AW205379 R80128 AA383242 AI016394 AA035115
		AI309333 AI568254 AI094665 W04770 W24624 F27773 AA378373 AA353029 R50427
		BF341287 R99348 BF374303 N75319 AA563593
		BF933630
400120	133_1	BC014030 NM_004068 BC004996 AK057883 D63475 BM468205
		BG386792 BG750447 BG575842 BG479084 BG741027 AU118129
		BE901043 AU141281 BG825395 BG338276 BE396231 AU121493 AU131489 BF341132
		BG335659 BI769251 AU142779 AU124483 BG480828
		AU121353 BG702326 AU137866 BG759046 BI460601 BE887290 BG750415 BF127710
		BG757819 BI160266 AU122086 BG824046 BG744180
		BE884943 BM006610 BG702599 BI870749 BF307033 BI334771 BG480606 AU142599
		AU141336 BM018563 BI335565 AU138308 BE391241
		BG774488 BE278025 BG717959 BG706920 BE312567 AU138300 BE303034 BE303016
		AU139252 BE336797 BG470940 BE336735
		BF305197 AU134288 AU139907 BE261245 BE208718 BG761912 BF212890 AW732692
		BM011258 AW247629 AU136696 BF530078
		BF204146 AL048752 BG328927 BE388385 BE260122 AU138789 BE253465 BF733914
		AW249415 AW239535 BE311791 BE256236 BF529742
		BG770465 AW245777 AW245813 BE296677 BE266852 BE168115 BE396596 BE280057
		BE168229 AI750820 AU134137 BF792191 AI272215
		AI907348 AW238875 BF805152 BF568397 BE712727 BE081443 BE001805 BF724536
		BF744705 AW247385 BE796369 AU133759 AV705142
		BE794402 BM465821 BG281284 AW384831 BM450689 AU134125 BE311650 BF356318
		BM462831 BG420555 BE749127 AU134590
		BM019438 BC013796 BG761223 BG122058 BE872076 BG748496 BG821374 BE619159
		BG423244 AU137110 AU127210 BE270081
		AA496860 AA351380 AA356303 AU099781 AA355912 AA371411 AA325535 U36188
		AL569574 AL577204 AL525543 AL567342 AL567334
		AL567122 AL536527 AL567098 BG681585 BG824951 BI870652 BI225855 AW393878
		BG750632 BI223803 BE877552 BE270473 BE389392
		BE779021 BM017845 BI117816 BE396513 BM049006 AW393945 BE786941 BE267724
		BE562981 BE314236 BF744102 BM019781 BF806063
		AA909846 BF924341 AW361460 AA425174 BE940557 BF761585 BF931276 BF934886
		W68597 BF933977 BI035906 BE836064 BF837576
		BI018368 AA205908 H54612 R88902 BE812330 BE932300 BF924562 AW805376 BE769859
		R87381 M371901 BE838855 AA326381 W56191
		AA341231 AA464093 AL575977 AL518650 AL547393 BG338327 AL517563 AL536921 BG207096
		BG207589 BG199290 BG220159 BG744842
		BG104730 AA555035 AA618009 AA861062 AA610582 AW245418 AI040983 AA521380
		AW245455 AU147292 AU155236 BE620286
		AW250767 BF888236 BE620819 AU154343 AU150827 AU148334 AW069495 AA701091
		AU155225 AW250019 AA666235 AU147764
		AA449739 BF907598 AW043731 AU144390 AI924565 BE300631 AW874021 BE208088
		BF732773 BF594057 AI159873 AU143930 N24100
		AI052499 AI989370 AI366151 AI139248 AU144776 AA838250 AI095433 Al269227
		BF811358 AU151352 AA477554 AI131290 AI049797
		AU157349 AA620559 AA581533 AI338299 AA402755 AI050079 AU157614 AI280691
		AA706590 BE206615 AA861056 AU153214 AU155712
		AW069554 AI081124 AU155846 AI081123 AA719876 AI754976 AI027763 AA723095
		BI518782 AW050706 F37521 R79062 AA565530 H39826
		AA404670 AU158884 AI139682 AA513633 AI283202 AA651856 AI623515 AA427413
		AW248474 BF841432 BM453246 AI302390 AA808269
		AI249357 AA132775 AA716732 AA479932 AI198296 AI208674 AI088433 F36977
		AA496899 AW615762 AA602541 AA341161 D58785 T15399
		AI286077 W69152 F28418 AI272156 AA338034 AA568455 BE206121 AI080033
		AI699680 AA861255 AI953465 AI613240 AL581773 AL531577
		BF526361 AA657809 AW152670 BE621523 AW078705 AW673719 AA102613
		AA195604 R72209 AA402208 AA404305 N24999 AI963535
		D54741 BI461415 BM475959 BI260926 BI116213 BE280120 BE940258 BE280044
		AI905744 BG001474 BE937718 BF799283 BI091621
		BG421006 BG289235 BF736825 BI253429 BG170064 R72512 T92815 BF931257
		BM455183 BG033362 BG574220 N31395 BF739185
		AA371995 BE879011 BI198754 BF378989 T12266 BM019421 BI194570 BF378992
		AW996595 BI858649 W94605 W61345 AA122384
		AA171923 T92736 AA761504 AI819039 AI439358 AL517777 AL565919 AA622001
		AA642695 AA704144 AA081465 AA070621 AA375562
		AA700011 AA926863 W37310 AL566236 BF677809 BG760021 AW361433 BE828605
		BE268449 BF805977 BG292452 BF981071 BF217108
		BF928698 R33993 AW882841 AI857453 AW078733 AI433035 AI018103 R90927
		AA804720 AA551734 R33835 H19741 R78754 BF930494
		BG109583 AA631926 BE834008 BG996533
437580	1240047_1	AW976343 AA761075 AA983906
433162	2167905_1	AI742311 AI025842 AA578843
412240	8235_1	BF963346 BI460763 BI599382 AI188089 AY055003 AW959185 AA187681 AI692282 AU153608
		BI493898 BI493899 AI797349 BE550679
		AI701137 AA744561 AA082682 BE218816 AW511501 BF447881 AI859101
		BF059295 AI914038 AI346564 AI685003 AI676076 AI125336
		AW469637 T10225 AI831296 R53451 AI453440 AA983739 AW470873 AI348290
		BE857670 D55901 Z43908 T34429 F07305 AK074340
		AL538118 BG201484 AI334192 T35535 AW176751 BI496132 BI496133 AA469961
		H72176 BF326265 AI770016 AI693177 BF223634
		BF963661 BF962265 BI034894 AI475851 N69071 AI910707 BE219038 AI918036
		BE670589 BM193515 AI338497 AA805525 AA487625
		AA830336 AA749368 AW104323 AI628055 AI932332 AI272788 AI536849 AW162414
		AW161923 T23854 AA610763 AA912188 AW339028
		Z39946 T10224 F03171 AI205478 AI638791 F02580 F01551 AW207551 AA421030
		BE246012 BI034937 BI035373 BF939581 H19984
		BE867247 H92677 N55988 BF957332 H18615 R16442 BF956229 BF961886 R12698
		AA101186 AA365932 R53452 BF062714 BF959364
		H41634 AW086187 H19985 BF054881 F02581 H18616 H41527 AW003446 BE243443
		H92276 AW954002 BI670132
447881	44623_1	AK074291 AW293424 BE676135 AI832125 BE019146
		BE465019 AI761124 AA617778 AI279232 AW575897 AI672039 F28618 BF924261
		AA722184 BF934174 BE004328 AV749301 BE880282 BI019798 BI019389 BF928776
		AW813409 AV726604 AA077560 BE272975 BF949119
		AW814195 BE879126 AI697926 BF594155 BE205787 BF063513 N35828 AI948557
		AI433839 AI379679 BG056182 AI589094 N23123
		AA588805 AW316581 AI080272 AI421980 AI493318 BF194830 N87590 AA495993
		N32996 AA699844 H96845 H96592 N28741 BI035539
		BF747723 BF171066 W01350 H05495 AI243785 Z39622 AA887432 AI350659 R46102
411590	2329293_1	T96183 T64070 AA094134
414588	296561_1	AA495793 AA302905 AA149783 BI059949 BF916498 BF924146 AW838065 BF990024 AW837915 AW837899 AW837927
		AW837919
		AW837903 AW838051
446126	610_2	BF946219 BF946218 BF851494 AL536879 AA457150 AI590194 AI582629
		AA464515 AA916242 M337109 AA336509 N46906 AA336322
		AA336407 AA337222 AA319240 BI026817 BI027058 AL536880 AI693827 AA651730
		AI701013 BM068789 AW339506 AA293021 BF891108
		AI458885 AW361203 AW974652 AI761251 AI655763 AA628063 BE047125
		AW085916 AI129587 N52070 AW172361 AA052951 AW085909
		AI000008 AA962570 AI371342 AI364207 AA464514 AI962506 AI824603
		AW376300 AA058439 AW361192 AV656660 N50282 BF820514
		BF891008 H40784 BF891112 BE708029 AW043567 AA056762
438619	35124_1	NM_016575 AB032773 AI765521 BF593742 AI497757 AI761233 AW467938 BF000670
		AI818496 N24761 AL043306 BF476138 BF593836
		AA132787 AI147248 AI086795 AA151317 T95298 AW083548 AA058371 N27951
		AI769860 AI784548 AW205506 AI800679 AI041733 AI459902
		BE327641 AI865829 AI254736 AI302433 AI744176 AI241825 AA027842 AL524933
		AL524932 BF947764 BF340737 BF948700 BG996395
		N53455 N21027 AI127616 N35901 M682443 AA678249 AA719371 M132582 T15981
		H99958 N40717 AW959402 AI267251 BF909329
		AI142035 T95379 H29420 R59632 H17318 H17331 H29327 R40829 R43395 R59573
		AI749561 R56599 H16755 AI694500 AA027907
411468	1085621_1	AW857472 AW847920 AW857357 AW857470 AW857354
432709	1870037_1	H17238 AA563739 F05559 F06116
414883	8371_2	AF274943 BG494894 AI719075 AA908783 AI935150 AI422691 AA910644 AA583187 BM272167 AI828996
		AA527373 AW972459 AI831360
		AA772418 AI033892 AA100926 AU154749 AI459432 AI423513 AI094597
		AA740817 AI991988 AI090262 AI312104 BI256707 AA459522
		AA416871 AI075239 AI339996 AA701623 AI139549 AI336880 AA633648
		AI989380 AI362835 AA399239 AI146955 BF514270 N92892
		AI348243 AI278887 AA459292 AI494230 BF507531 AI492600 M962596 AW613002
		AA293140 AA235549 BF108854 AA954344 N49682
		AI457100 AW589407 AW300758 BE220715 BE220698 BE569091 BM009647
		BF900351 AI537692 AI203723 AI857576 AA584410 AW371667
		BM172363
449901	1269988_2	BI227033 AI674072
426295	510_1	BE880923 BG390191 AW470082 AW014585 AI423255 BI714731 BG054894 AW780248 N31683 AW664132
		AW467353 AI983152 AA617918
		BF447795 AI088357 AA807328 AA576970 AI741153 AI755003 AI474016
		AI422030 AI348114 AW997085 BM271753 AI363147 BM311311
		AM146640 AI246771 AW512619 AI359020 BG054897 AI292234 AI215830
		AI283836 C06205 AW503423 AW272680 N33205 AW873021
		AA070724 AI753886 AW192487 AI087151 AA658909 AI346368 AI335677
		AA825442 AW440066 AW131357 AW513210 AI082314 AI085455
		BE551404 AA780704 AW008596 AI796964 AA917471 AI400531 AA668626
		N72207 AI306482 AW440562 AI084687 AA347280 AA063536
		BF477389 AI241662 AA931543 AA484310 AA812486 AI032216 AA665779
		AI916336 AI350590 BF198106 AI433377 AI300638 AI672626
		AI282741 AI351487 AW105544 AA973627 AW517914 AA715424 AA508454
		BF334080 AI274618 AW367201 AW572619 AW469088 AA382095
		AI368364 AI146934 AI357180 AI361181 BI911347 BI871044 AA136325
		BF084010 BF084007 AA335788 AI920878 AA809614 BE932941
		AI678261 C75308 AI148479 BE178174 W88513 BM013627
455705	77478_2	BF971018 BE513812 AA133359 AW581719 BF434402 AL600619 BG699731 BI551395 AW027136
		AW055130 BF939512 AI076048 H18584
		AW161061 AA864334 AI816101 BE049456 AW044012 AA954079 AI274682
		AI370526 AW131990 AA853195 AA853191 BG118295 AA761620
		BG705371 BF355591 BF336596 AA360497 H28072 BG198352 AW364709
		H40926 H44214 AA836538 BI059563
424571	9758_1	BE379766 AW152643 AI803450 AI564343 AI092711 AI140525 AW152156 AI620740 AI554689
		AI161209 AI290242 AI339745 AI374611
		AI347388 AI858296 Al140529 AI366124 AA493912 AA406235 AA493889
		AI057160 AW022264 AI097277 AM144126 AI080051 AA983529
		AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004
		AA626688 AA235977 AI057152 AI095366 AI095356 AA458646
		AW194479 AA150439 AI375272 AW571777 AI359198 AA993793 BE614394 BE738239
		AA127883 AI034344 T59504 D81608 AA908704
		AW051665 AA382785 AA307208 N24639 AI370715 BE244980 AA548596 AW449675
		AM91008 BF223749 N70752 N22266 AI191012
		AA028001 AI419106 BF215661 BF591548 BG942356 AI474968 BE858217 BF793358
		AV756758 BG483603 AI093724 BF693395 BG545345
		AI744294 T59549 AA811773 BG499757
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0356]

TABLE 70
Pkey	Ref	Strand	Nt_position
403790	8084957	Minus	87826-87947,89835-90002
405102	8076881	Minus	120922-121296
402727	9211324	Plus	54596-54777
405268	4156151	Minus	24404-24521
400517	9796686	Minus	49996-50346
405141	8980911	Plus	99861-100054
403738	7212067	Plus	38434-38562,56876-57007,
			59789-59876,6071
403904	7710675	Minus	8129-8261,41911-42053
402737	9212184	Minus	13358-13552
401091	9958240	Plus	94760-94898
402507	9797889	Plus	118979-119086
402964	9581599	Minus	46624-46784
406423	9256411	Plus	165600-165824
406038	8389537	Plus	37764-37877
401649	9090641	Plus	80229-80762
400475	9957990	Minus	64771-64887,67396-67563
403575	8101156	Minus	81961-82068
401016	8117441	Plus	126234-126359,128050-128236
405689	4508117	Minus	92558-92698,94282-94382,
			97977-98180.9920
403809	8568861	Plus	33910-34129,34583-34862
403671	7272159	Plus	104461-104701
402041	7770639	Plus	69353-69454
403478	9958258	Plus	116458-116564
403027	7670575	Plus	60696-60932, 61362-61521
400471	9931670	Minus	105629-105760
404433	7407979	Minus	124561-124764
401898	8570008	Minus	72013-72132, 72400-72487
402836	8745058	Minus	96756-96941
403330	8516153	Plus	116558-116698
403743	7652003	Minus	136463-136646
406274	7543787	Plus	932-1123
401197	9719705	Plus	176341-176452
404676	9797204	Minus	56167-56342, 58066-58189,
			58891-59048, 6045
401635	7145001	Minus	51895-52764
403976	7657840	Plus	24755-24969
401928	3873182	Plus	54932-55070
401952	3319121	Minus	53770-53979
405117	8096945	Minus	109169-109866
400557	9801261	Plus	208453-208528, 209633-209813
403920	7710868	Plus	40312-40490
403496	7523883	Minus	140940-141126, 144920-145123
405122	8137462	Minus	95449-95646
403320	8318526	Plus	127978-128124
405270	4156145	Minus	3952-4123, 6886-7010, 8541-8728
405688	4508117	Minus	88702-88899
401627	8575953	Minus	72828-73029
403576	6862645	Minus	73475-73940, 74079-74207
403742	7212067	Plus	84805-85525, 91096-91227,
			93970-94057, 9523
405086	8072509	Plus	73664-73841, 74081-74217,
			74610-74779, 7492
402929	8217647	Minus	51862-52032
404240	5002624	Minus	116132-116407, 116653-116922
400906	9966290	Plus	112863-112989, 120162-120286
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (Gl) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0357] Table 8A lists about 254 genes down-regulated in Hepatitis C positive liver tissues compared to Hepatitis C negative liver tissues. These genes have the potential to be diagnostics and/or prognostic markers for Hepatitis C infected liver tissues. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of Hepatitis C negative liver tissues to the “weighted average” of Hepatitis C positive liver tissues was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the Hepatitis C negative liver tissues was set to the trimean of several different Hepatitis C negative liver tissues. The “weighted average” of the Hepatitis C positive liver tissues was set to the either 10 or the trimean of several different Hepatitis C positive liver tissues, whichever value was greater to eliminate ratios with a denominator of zero or less.

TABLE 8A
Pkey	ExAccn	UniGene	Unigenen Title	R1	R2
451831	NM_001674	Hs. 460	activating transcription factor 3	2.25E−04	23.90
450912	AW939251	Hs. 25647	v-fos FBJ murine osteosarcoma viral onco	7.80E−06	23.32
414559	AV656184	Hs. 76452	C-reactive protein, pentraxin-related	9.77E−04	20.48
447078	AW885727	Hs. 9914	ESTs	2.93E−02	14.42
416188	BE157260	Hs. 79070	v-myc avian myelocytomatosis viral oncog	8.41E−04	12.75
451029	AA852097	Hs. 25829	ras-related protein	9.37E−03	10.77
434078	AW880709	Hs. 283683	chromosome 8 open reading frame 4	1.93E−03	10.32
442941	AU076728	Hs. 8867	cysteine-rich, angiogenic inducer, 61	9.18E−05	10.10
405278			NM_002864: Homo sapiens pregnancy-zone pr	5.19E−03	8.45
428106	BE620016	Hs. 182470	PTD010 protein	5.03E−04	7.47
446066	AI343931	Hs. 149383	ESTs	2.01E−03	7.30
407173	T64349		gb: yc10d08.s1 Stratagene lung (937210) H	4.77E−03	6.90
414220	BE298094	Hs. 101150	gb: 601118231F1 NIH_MGC_17 Homo sapiens c	5.74E−02	6.65
431319	AA873350	Hs. 302232	ESTs	1.19E−02	6.52
416434	AW163045	Hs. 79334	nuclear factor, interleukin 3 regulated	2.63E−02	6.50
448607	AL042506	Hs. 21599	Kruppel-like factor 7 (ubiquitous)	4.36E−03	6.50
420101	AW500529	Hs. 95180	KIAA0767 protein	6.53E−04	6.49
414327	BE408145	Hs. 185254	ESTs, Weakly similar to T24435 hypotheti	3.13E−04	6.32
446584	U53445	Hs. 15432	downregulated in ovarian cancer 1	5.39E−02	5.82
404501			nucleoside phosphorylase	6.12E−02	5.70
420548	AA278246	Hs. 920	ESTs	7.62E−03	5.68
409233	AK002001	Hs. 51305	v-maf musculoaponeurotic fibrosarcoma (a	1.09E−04	5.55
427509	M62505	Hs. 2161	complement component 5 receptor 1 (C5a I	7.95E−03	5.48
400425	AY004252	Hs. 287385	PR domain containing 12	1.91E−04	5.40
401149			Target Exon	2.04E−05	5.35
427557	NM_002659	Hs. 179657	plasminogen activator, urokinase recepto	3.33E−05	5.26
449986	AW864502		gb: PM4-SN0016-120400-004-b12 SN0016 Homo	3.61E−02	5.25
419299	AI311085		hypothetical protein FLJ22573	3.50E−03	5.15
450335	BE218355	Hs. 201781	ESTs, Weakly similar to B34087 hypotheti	3.06E−03	5.15
417752	C15737	Hs. 269386	ESTs	5.87E−04	5.07
423053	BE312679		gb: 601148138F1 NIH_MGC_19 Homo sapiens c	1.81E−04	5.02
448871	BE616709	Hs. 159265	kruppel-related zinc finger protein hcKr	2.22E−03	5.02
408278	AW876813		phosphoglycerate dehydrogenase	2.66E−04	5.00
431326	AW970580	Hs. 198689	KIAA0728 protein	6.12E−02	4.92
436068	AK000038	Hs. 300979	ESTs, Weakly similar to I38022 hypotheti	5.92E−03	4.85
409795	AI934808		ESTs, Weakly similar to T46338 hypotheti	2.32E−03	4.84
430070	AF197927	Hs. 231967	ALL1 fused gene from 5q31	2.94E−05	4.83
411929	AA098880	Hs. 69297	ESTs	1.14E−02	4.75
402273			Target Exon	2.11E−03	4.72
453196	AW003567		ESTs	3.50E−03	4.72
418303	AA215701	Hs. 186541	ESTs, Weakly similar to I38022 hypotheti	2.63E−02	4.70
455510	AA422029	Hs. 143640	ESTs, Weakly similar to hyperpolarizatio	6.12E−02	4.65
423720	AL044191	Hs. 23388	hypothetical protein DKFZp434F0318	1.13E−03	4.63
402517			Target Exon	1.13E−03	4.61
454598	AW809716		gb: MR4-ST0124-241199-026-h09 ST0124 Homo	3.06E−03	4.40
448429	D17408	Hs. 21223	calponin 1, basic, smooth muscle	1.89E−02	4.35
429258	AA448765	Hs. 184252	gb: zx10e09.r1 Soares_total_fetus_Nb2HF8—	7.00E−03	4.34
412176	AW898334		gb: RC3-NN0070-270400-011-f02 NN0070 Homo	7.60E−04	4.27
441269	AW015206	Hs. 178784	ESTs	1.29E−02	4.22
458867	AW995393		gb: QV0-BN0042-170300-163-g12 BN0042 Homo	1.16E−06	4.22
417732	R36065		gb: yg69h06.r1 Soares infant brain 1NIB H	9.14E−05	4.13
444863	AW384082	Hs. 104879	serine (or cysteine) proteinase inhibito	6.12E−02	4.13
415477	NM_002228	Hs. 78465	v-jun avian sarcoma virus 17 oncogene ho	7.23E−04	4.12
415994	NM_002923	Hs. 78944	regulator of G-protein signalling 2, 24 k	9.78E−04	4.05
417551	AI816291	Hs. 82273	hypothetical protein	4.30E−04	3.98
426006	R49031	Hs. 22627	ESTs	3.61E−02	3.95
401553			Target Exon	8.32E−02	3.95
432877	AW974111	Hs. 292477	ESTs	9.36E−02	3.92
410052	AA525225	Hs. 334630	Homo sapiens cDNA FLJ14462 fis, clone MA	1.14E−02	3.92
459476	BE185844		gb: IL5-HT0731-110500-087-c08 HT0731 Homo	7.31E−03	3.92
404958			Target Exon	9.30E−04	3.90
431394	AK000692	Hs. 252351	HERV-H LTR-associating 2	4.76E−03	3.88
403324			C2000428*: gi|7705383|ref|NP_057536.1|GC	1.34E−02	3.88
447744	AA313230	Hs. 19413	S100 calcium-binding protein A12 (calgra	1.69E−02	3.88
447802	AW593432	Hs. 161455	ESTs	1.83E−03	3.87
424946	M64572	Hs. 153932	protein tyrosine phosphatase, non-recept	5.38E−02	3.85
401913			ENSP00000249158*: CDNA	8.32E−02	3.84
430389	AL117429	Hs. 240845	DKFZP434D146 protein	1.10E−02	3.83
441188	AW292830	Hs. 255609	ESTs	3.14E−02	3.82
449236	AJ403126	Hs. 26373	Homo sapiens cDNA: FLJ23449 fis, clone H	4.73E−02	3.82
446052	AA358760	Hs. 95893	gb: EST67699 Fetal lung II Homo sapiens c	2.16E−05	3.81
431861	AA521072	Hs. 292128	ESTs	5.29E−04	3.76
411993	AA099329	Hs. 151764	ESTs	2.54E−02	3.75
449335	AW150717	Hs. 345728	STAT induced STAT inhibitor 3	2.11E−03	3.73
403794			Target Exon	1.08E−03	3.71
409840	AW502122		gb: UI-HF-BR0p-ajr-c-08-0-Ul.r1 NIH_MGC_5	4.51E−05	3.67
410057	R66634	Hs. 268107	multimerin	1.39E−02	3.65
456525	AW468397	Hs. 100000	S100 calcium-binding protein A8 (calgran	4.57E−02	3.65
447572	AI631546	Hs. 287331	zinc finger protein ZNF286	1.45E−03	3.65
449785	AI225235	Hs. 288300	hypothetical protein FLJ23231	1.69E−02	3.65
412568	AI878826	Hs. 74034	caveolin 1, caveolae protein, 22 kD	2.93E−02	3.64
454985	AW849292		gb: IL3-CT0215-020300-090-E06 CT0215 Homo	2.04E−02	3.63
424554	AA747563	Hs. 131799	ESTs, Weakly similar to ALU8_HUMAN ALU S	2.93E−02	3.60
440535	AI590563	Hs. 125910	ESTs	5.43E−03	3.60
403180			Target Exon	1.15E−04	3.58
435715	T78013	Hs. 167279	FYVE-finger-containing Rab5 effector pro	7.62E−03	3.57
402651			NM_000721*: Homo sapiens calcium channel,	1.31E−03	3.57
419555	AA244416		gb: nc07d11.s1 NCI_CGAP_Pr1 Homo sapiens	1.53E−04	3.54
404359			Target Exon	5.67E−03	3.52
418525	AW450369	Hs. 86937	ESTs	2.32E−03	3.52
453899	AW134536	Hs. 243994	ESTs	5.20E−03	3.52
402889			ENSP00000217123*: FLJ00118 protein (Fragm	1.31E−03	3.52
403796			Target Exon	9.27E−04	3.50
404473			ENSP00000247423: D-siglec precursor.	1.18E−03	3.50
408120	AW299900	Hs. 267632	TATA element modulatory factor 1	2.55E−03	3.50
447819	U90544	Hs. 19710	solute carrier family 17 (sodium phospha	2.45E−02	3.50
402023			Target Exon	7.83E−02	3.47
415897	H08323	Hs. 268712	ESTs	2.13E−04	3.47
445402	AI222415	Hs. 147852	ESTs	1.08E−03	3.47
404518			CD83 antigen (activated B lymphocytes, i	7.15E−02	3.45
450875	AK000724		karyopherin alpha 6 (importin alpha 7)	2.65E−04	3.45
454636	AW811502		gb: QV2-ST0145-061299-015-b04 ST0145 Homo	5.43E−03	3.44
403579			Target Exon	1.96E−02	3.40
456782	AK000462	Hs. 132071	ovarian carcinoma immunoreactive antigen	1.15E−04	3.39
433010	AW970018		gb: EST382097 MAGE resequences, MAGK Homo	3.05E−03	3.35
443725	AW245680	Hs. 9701	growth arrest and DNA-damage-inducible,	1.92E−05	3.33
400407	AF210247	Hs. 283949	enamelin	7.19E−04	3.32
432304	AA932186	Hs. 69297	ESTs	1.25E−03	3.32
447721	BE619620		lysyl oxidase	5.40E−05	3.32
433095	AK001092	Hs. 302480	Homo sapiens cDNA FLJ10230 fis, clone HE	2.92E−03	3.30
442364	AA993149	Hs. 129895	ESTs, Moderately similar to TBX3_HUMAN T	5.58E−04	3.30
444080	AW812664		gb: RC4-ST0185-191099-012-h10 ST0185 Homo	4.41E−02	3.30
403545			Target Exon	1.03E−03	3.26
454741	BE154396		gb: CM2-HT0342-091299-050-b05 HT0342 Homo	8.27E−03	3.24
428177	AA423967		ESTs	8.37E−04	3.24
454292	N57559	Hs. 82273	hypothetical protein	5.05E−02	3.22
427536	BE277141	Hs. 115803	gb: 601178666F1 NIH_MGC_20 Homo sapiens c	8.81E−04	3.20
439760	AL355741	Hs. 21641	Homo sapiens mRNA full length insert cDN	1.31E−03	3.20
450799	AW407504		gb: UI-HF-BM0-adk-g-12-0-UI.r1 NIH_MGC_38	1.08E−03	3.16
447135	T58148		gb: yb98g06.s1 Stratagene lung (937210) H	2.38E−04	3.13
417079	U65590	Hs. 81134	interleukin 1 receptor antagonist	5.21E−03	3.11
428568	AC004755		Homo sapiens chromosome 19, fosmid 37502	1.19E−03	3.11
406060			Target Exon	2.02E−03	3.07
421224	AW402154	Hs. 125812	ESTs	1.92E−03	3.05
459399	BE407712	Hs. 153998	creatine kinase, mitochondrial 1 (ubiqui	3.06E−03	3.05
440509	BE410132	Hs. 134202	ESTs, Weakly similar to T17279 hypotheti	2.25E−04	3.05
408952	S79854	Hs. 49322	deiodinase, iodothyronine, type III	6.52E−04	3.04
410619	BE512730	Hs. 65114	keratin 18	8.62E−03	3.03
452236	AI130858	Hs. 143218	ESTs	1.29E−02	3.02
436651	BE045962	Hs. 275998	ESTs	5.55E−02	2.97
430071	AA355986	Hs. 232068	transcription factor 8 (represses interl	2.04E−02	2.97
405600			C12001673: gi|9631264|ref|NP_048045.1|or	2.19E−02	2.97
416666	H73028	Hs. 268992	ESTs	2.13E−04	2.96
414141	BE255083	Hs. 145729	hypothetical protein DKFZp564A1164	2.92E−03	2.95
427408	AA583206	Hs. 2156	RAR-related orphan receptor A	9.92E−02	2.92
422017	NM_003877	Hs. 110776	STAT induced STAT inhibitor-2	4.57E−03	2.92
444047	AI097452		ESTs	2.73E−02	2.90
440898	AL035690	Hs. 165	glucagon-like peptide 1 receptor	1.96E−02	2.90
408253	AW807476	Hs. 21051	Homo sapiens mRNA for FLJ0012 protein,	2.11E−02	2.88
446912	AI347650	Hs. 128521	ESTs, Moderately similar to ALU4_HUMAN A	2.54E−03	2.88
457148	AF091035	Hs. 184627	KIAA0118 protein	2.32E−03	2.86
444207	AI565004		cathepsin D (lysosomal aspartyl protease	3.53E−05	2.84
438460	AB020702	Hs. 6224	KIAA0895 protein	1.51E−03	2.82
405502			C7000609*: gi|628012|pir||A53933 myosin I	4.72E−02	2.82
453560	AA348626	Hs. 5890	hypothetical protein FLJ23306	1.19E−02	2.82
417213	BE257508	Hs. 24719	modulator of apoptosis 1	5.05E−05	2.81
403582			Target Exon	8.57E−02	2.80
408112	AW451982	Hs. 248613	ESTs	2.83E−02	2.80
437180	BE180234	Hs. 281462	Homo sapiens cDNA FLJ14793 fis clone NT	2.67E−03	2.79
412429	AV650262	Hs. 75765	GRO2 oncogene	1.01E−06	2.79
421993	R22497	Hs. 110571	growth arrest and DNA-damage-inducible,	1.62E−04	2.79
407338	AA773213	Hs. 200558	gb: ab66f10.s1 Stratagene lung carcinoma	2.32E−03	2.78
448778	AF074913		gb: Homo sapiens transcription factor Pax	1.14E−02	2.77
422743	BE304678	Hs. 119598	ribosomal protein L3	2.36E−02	2.75
427413	BE547647	Hs. 177781	hypothetical protein MGC5618	5.43E−03	2.70
447306	AI373163	Hs. 170333	ESTs	5.21E−02	2.70
447526	AL048753	Hs. 303649	small inducible cytokine A2 (monocyte ch	2.20E−02	2.69
400818			Target Exon	2.26E−04	2.69
432128	AA127221	Hs. 296502	ESTs	3.25E−02	2.67
414890	BE281095	Hs. 77573	uridine phosphorylase	1.59E−03	2.65
413731	BE243845	Hs. 75511	connective tissue growth factor	2.45E−02	2.65
434180	AA921757	Hs. 116180	ESTs	1.37E−04	2.64
435992	AI033259	Hs. 118317	Homo sapiens cDNA FLJ12088 fis, clone HE	2.83E−02	2.63
419180	T95449	Hs. 220817	ESTs	1.56E−02	2.63
457054	NM_014137	Hs. 177258	PRO0650 protein	1.75E−02	2.63
432745	AI821926		gb: nt78f05.x5 NCI_CGAP_Pr3 Homo sapiens	7.21E−04	2.62
427899	AA829286	Hs. 332053	serum amyloid A1	1.75E−03	2.61
405443			Target Exon	6.44E−03	2.61
428403	AI393048	Hs. 326159	leucine rich repeat (in FLII) interactin	6.94E−02	2.61
409463	AI458165	Hs. 17296	hypothetical protein MGC2376	2.63E−02	2.60
402878			ENSP00000217420*: BA122O1.1 (A novel prot	3.12E−04	2.57
404046			NM_019120*: Homo sapiens protocadherin be	1.66E−03	2.56
458873	AW150717	Hs. 345728	STAT induced STAT inhibitor 3	3.05E−03	2.55
426653	AA530892	Hs. 171695	dual specificity phosphatase 1	2.52E−04	2.55
411920	AW876263		gb: PM4-PT0019-131299-006-E09 PT0019 Homo	1.75E−02	2.54
454339	AW381980		gb: QV4-HT0316-091199-028-05 HT0316 Homo	2.04E−02	2.52
432909	AA570111		ESTs, Weakly similar to ALUE_HUMAN !!!!	1.30E−03	2.51
411283	AW852754		gb: PM1-CT0247-180100-009-c05 CT0247 Homo	3.03E−02	2.50
415759	AA169182	Hs. 182740	gb: zp20e02.s1 Stratagene fetal retina 93	2.43E−03	2.50
447650	AW581199	Hs. 161137	ESTs, Moderately similar to 154374 gene	8.28E−03	2.50
402012			ubiquitin specific protease 15	3.88E−04	2.50
423499	AW608884	Hs. 28068	ESTs	2.96E−04	2.49
402124			NM_031891: Homo sapiens cadherin 20, type	3.05E−03	2.47
412755	BE144306	Hs. 179891	ESTs, Weakly similar to P4HA_HUMAN PROLY	1.38E−03	2.47
418443	NM_005239	Hs. 85146	v-ets avian erythroblastosis virus E26 o	1.37E−04	2.47
419239	AA468183	Hs. 184598	Homo sapiens cDNA: FLJ23241 fis, clone C	6.72E−02	2.47
419909	AL136653	Hs. 93675	decidual protein induced by progesterone	1.08E−03	2.45
402608			CD83 antigen (activated B lymphocytes, i	4.57E−02	2.44
402022			Target Exon	4.00E−03	2.42
458568	AI769067	Hs. 127824	ESTs, Weakly similar to T28770 hypotheti	8.65E−05	2.42
442702	AW235697	Hs. 130980	ESTs	6.12E−02	2.42
424236	AW058114	Hs. 7837	phosphoprotein regulated by mitogenic pa	6.17E−03	2.42
427700	AA262294	Hs. 180383	dual specificity phosphatase 6	2.04E−02	2.41
410204	AJ243425	Hs. 326035	early growth response 1	4.00E−03	2.41
424221	NM_014478	Hs. 300684	calcitonin gene-related peptide-receptor	8.59E−05	2.41
401376			Target Exon	8.26E−03	2.40
456147	H41324	Hs. 31581	ESTs, Moderately similar to ST1B_HUMAN S	4.28E−02	2.40
407654	AW064121	Hs. 279175	ESTs	1.83E−03	2.38
402364			CCAAT/enhancer binding protein (C/EBP),	3.25E−02	2.37
438808	M73980	Hs. 129053	Homo sapiens NOTCH 1 (N1) mRNA, complete	1.30E−05	2.36
401942			C17001396*: gi|3212355|pdb|1A4P|A Chain A	3.80E−03	2.33
426521	AF161445	Hs. 170219	hypothetical protein	3.03E−02	2.32
446378	AI905699		citrate synthase	3.18E−03	2.31
408935	BE539706	Hs. 285363	ESTs	4.77E−03	2.31
424028	AF055084	Hs. 153692	Homo sapiens cDNA FLJ14354 fis, clone Y7	6.93E−02	2.29
433070	N75346		CDC20 (cell division cycle 20, S. cerevi	5.56E−02	2.29
456825	H67220	Hs. 169681	death effector domain-containing	1.24E−02	2.26
459711	BE386801	Hs. 21858	trinucleotide repeat containing 3	8.29E−03	2.26
406140			Target Exon	8.12E−05	2.26
400327	M18679		Human variant 5S rRNA-like gene and ORF,	8.07E−02	2.25
455968	BE168828		gb: QV1-HT0517-020400-145-f04 HT0517 Homo	2.65E−04	2.25
431387	AI878854	Hs. 252229	v-maf musculoaponeurotic fibrosarcoma (a	1.75E−02	2.24
421233	AA209534	Hs. 284243	tetraspan NET-6 protein	1.82E−02	2.23
401522			CGI-35 protein	5.42E−03	2.22
422831	R02504	Hs. 332943	ESTs	1.14E−02	2.22
401346			hypothetical protein	2.93E−02	2.21
410268	AA316181	Hs. 61635	six transmembrane epithelial antigen of	2.36E−02	2.20
434495	AW352170	Hs. 129086	Homo sapiens cDNA FLJ12007 fis, clone HE	1.56E−02	2.20
442321	AF207664	Hs. 8230	a disintegrin-like and metalloprotease (	1.69E−05	2.19
458692	BE549905	Hs. 231754	ESTs	7.60E−02	2.19
403750			C5001092: gi|6671939|gb|AAF23199.1|AC0167	5.90E−03	2.18
441516	F06700	Hs. 7879	interferon-related developmental regulat	2.93E−02	2.18
423503	M92843	Hs. 343586	zinc finger protein homologous to Zfp-36	1.19E−03	2.18
456465	M94065	Hs. 94925	dihydroorotate dehydrogenase	6.84E−05	2.17
440249	AI246590	Hs. 249175	ESTs	1.53E−04	2.16
459235	BE246010		Homo sapiens mRNA for FLJ00038 protein,	4.54E−04	2.15
409540	AW409569	Hs. 101550	gb: fh01e09.x1 NIH_MGC_17 Homo sapiens cD	7.98E−04	2.14
412541	BE009398	Hs. 74002	nuclear receptor coactivalor 1	7.31E−03	2.13
449713	AW027025		ESTs	6.19E−04	2.13
442351	W52642	Hs. 8261	hypothetical protein FLJ22393	8.39E−04	2.13
407869	AI827976	Hs. 24391	hypothetical protein FLJ13612	3.06E−03	2.13
411372	AI147861	Hs. 213289	low density lipoprotein receptor (famili	7.71E−05	2.12
423168	R34385	Hs. 124940	GTP-binding protein	1.06E−02	2.11
414002	NM_006732	Hs. 75678	FBJ murine osteosarcoma viral oncogene h	4.02E−06	2.10
419048	T91158	Hs. 268605	ESTs	1.37E−03	2.09
433178	AB038269	Hs. 253706	cysteinyl leukotriene CysLT2 receptor; c	1.92E−03	2.08
432190	T80206	Hs. 14716	ESTs	1.25E−03	2.07
447261	NM_006691	Hs. 17917	extracellular link domain-containing 1	9.36E−02	2.07
436869	NM_014867	Hs. 5333	KIAA0711 gene product	2.67E−03	2.06
402441			Target Exon	4.77E−03	2.05
441475	AI929602	Hs. 177	phosphatidylinositol glycan, class H	2.02E−04	2.05
404126			ENSP00000211797*: Helicase SKI2W (Helicas	1.08E−03	2.05
443514	BE464288	Hs. 141937	ESTs	8.57E−02	2.05
404187			NM_019602: Homo sapiens butyrophilin-like	3.35E−03	2.03
424125	M31669	Hs. 1735	inhibin, beta B (activin AB beta polypep	1.82E−02	2.03
400409	AF153341		Homo sapiens winged helix/forkhead trans	4.37E−03	2.02
404752			NM_024778: Homo sapiens hypothetical prot	2.82E−02	2.02
449338	H73444	Hs. 394	adrenomedullin	2.36E−02	2.02
437389	AL359587	Hs. 271586	hypothetical protein DKFZp762M115	2.63E−02	2.02
401405			Target Exon	3.49E−02	2.01
429446	AI547111		gb: PN2.1_A01_G12.r mynorm Homo sapiens c	2.36E−02	2.01
431111	AB033072	Hs. 250015	KIAA1246 protein	1.44E−04	2.01
406210			Target Exon	1.82E−02	2.01
417076	AW973454	Hs. 115175	ESTs, Moderately similar to ALU7_HUMAN A	2.04E−02	2.00
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of Hep C− Liver over Trimean of Hep C+ liver Ratio

[0358]

TABLE 8B
Pkey	CAT Number	Accession
449986	2292_10	AK055879 AW007836 AA873089 N74374 AV720071 AA702706 AW055276
		BE672779 AW864502 AI678780 AW864369 AI052145 T40984
		N74426
419299	36328_1	BM477587 BE675426 AA827059 AI597639 AI571409 AI719948 AI311085
		AA953361 AI498787 AI364049 AI311084 BF871020 BE549868
		AI356384 AA236660
423053	367623_1	BE314223 AA320990 BE312679 BI054000 BI324838 AW057717
408278	MH337_68	BG422281 BG422108 AW177973 BG750536 AW876813 AW876814
409795	MH905_27	AI498073 AI934808 AW374654 BI036066 BE709215 AA077985 BI831355
		BF932450 BF770705 BF379220 AA077682 AA076814 AA076875
		BI027970 AA077787 AA077311 BF811798 AW393752 BF327269 AA077305
		AA078114 BF800885 BF942930 AW903223 BF916052 AW903170
		AW903224 BF352664 BF379209
453196	505145_1	AW003567 AI963955 AI990231
454598	1063474_1	BF374577 AW809840 AW809996 AW809798 AW809695 AW809646 AW809738 BF374582
		AW809716 AW809826 AW809802 AW809747
		AW810152
412176	199671_1	BF818635 AW898334 H66426 AW899792
458867	1246993_1	AW995393 AJ403118
417732	299677_1	R12062 R12616 Z43412 R36065
459476	169217_1	AA584407 BE185844 BF764955
409840	915929_1	AW502122 AW501663 AW501720 AW502125
454985	1087722_1	AW849431 AW849428 AW849424 AW849422 AW849420 AW849292 AW849427
419555	252042_1	AA244401 AA244416
450875	10801_1	AL041364 BE393266 AA573189 BF589066 AI623423 AI889612 H54292
		AA085863 AA669816 BE542832 BI094274 AI360690 T61853 AW081194
		AI541147 AW750358
454636	1064998_2	AW811471 AW811548 AW811521
433010	1234715_1	AW970018 BE843649 BE843644 AA573622 R08736 AA573669
447721	1889_2	BC013767 AL572931 BE742185 BI520113 AW959076 AI341487 AI623222 BM091074
		AW593800 AI983635 AW275114 AI952164 BM091378
		AA977038 AW513859 AI801910 AW273202 AW166266 AW337946 AI086791
		BE907359 AW273147 AI453134 AA250733 AW072844 AI818468
		AI561259 AW470887 AW300481 AW103087 AW175624 BE048584 BF063936
		AI207341 AW193240 AW193322 AW264492 AI682412 AI631778
		AI669677 AI128695 AA448630 AA456607 BF313680 BG898294 BI195544
		BG421755 BI760100 BE383304 BF329916 BF526599 AA385255
		BI520887 AA410939 AA448721 BF525380 BG423666 BI761786 BF944570
444080	20054_4	AL545854 H05874 AW812663 BE146011 AW812664 AV647861
		AW812655 AW812611 BG718126
454741	220369_1	BE154396 BF846839 AW842318 AW817959 BE154393 BI050168
428177	8737_7	AA779866 AA423967 AA423968
450799	819959_1	W31274 AW407504 AI738877
447135	579607_1	T58148 AW516579 AW059603
428568	738084_1	BE259137 BE251523
444047	56634_1	AK057279 AI939345 BF748883 AI161300 AI097452 AI097450 BF958187 BE936529
		AW890840 AW890825 BE763814 AW408933 BI038453
		BE735308
444207	9172_3	BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464
		AA514889 AW819039 AW819083 BE843048 AI432496
		AI470335 AI247243 BG533994 AA513783 AI887309 AA528036 AW972006 AW873028 AI924914 AI818810
		AW152378 AW084946 AI521413
		AI669583 BE932521 AI581370 BE180238 AW089750 AW771461 AW089714 AI590949 AI819148
		AA731056 BF815234 BF911506 AA235803
		AA485373 AI735658 AW393133 AW073080 AI707637 BF353320 BE843111 AW819036 AW393135
		BG697291 AV648670 AV654332 AV687530
		BG566964 AI807430 AI676072 AA837010 AI452482 AI625817 AW241750 BE048616 AI290928
		AI680714 AA485530 BE175687 AV648513
		AW130312 AI000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345
		AI244948 AA602956 AA483492 AA918178
		AW802049 BG675859 AV658871 BG678060 AI565004 AW819026 BE843092 AV686437 AV723049
		BG616948 AI911647 AI743490 AI091096
		BE857251 AI962074 AA040027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876
		BE843095 BE843140 BG536641
		BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996
		AI749532 BE768614 BE857252 BE932516
		BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793
		BE180119 BG617338 H45942 T55897 AV657718
		BG563497
448778	7800_1	AW505435 U62539
432745	112643_1	AA658826 AI821926 AI791191 AA635129 AA564492
411920	1141803_1	AW876134 AW876141 AW876398 AW876328 AW876308 AW876331 AW876415 AW876326
		AW876181 AW876138 AW876131 AW876240
		AW876206 AW876289 AW876218 AW876261 AW876343 AW876347 AW876188
		AW876371 AW876273 AW876231 AW876191 AW876209
		AW876322 AW876314 AW876165 AW876363 AW876378 AW876376 AW876169 AW876412 AW876426
		AW876407 AW876257 AW876263
		AW876366 AW876334
454339	789006_1	BE152238 AW381980 BE152235 BE152244 BE152232
432909	137712_1	AA702596 AA570111 AI348435 AW192161
411283	215263_1	AW852754 AW852757 AW852617 BE172755 AW852897 AW835444 AW835440
		AW801490 AW801489 BF839901 AW835520
446378	10288_1	BC010106 AL560552 AU133296 AU133086 BE268567 BE268523 BI544879
		BE398161 BG473088 BI544445 BE258021 BE296339 BE255040
		BE263020 BG706790 AL598627 AW952337 BG758113 AW512753 BE267666 BE253415 BI225718 BE268350
		BE258245 BI224965 AW772605
		BG723903 BE397282 BI196341 BG702880 AI878949 AL600437 AA416759 BE259917 AI031582 BF512142
		AI088248 BE560328 AI802623
		AI288613 AL597585 AW768553 AI816352 BF732831 BI225687 AA833686 AA722593 AA807750
		AW068064 AA405187 AI923236 N51593
		AL527710 BG282576 AL525927 AL525971 BI869547 AI064725 R91856 H46814 H20112
		W01682 AW848870 AW848585 AW376662 AW848985
		AW848937 AW848862 AW848581 AW848512 AW848176 AW752623 AW752618 AW376822
		AW376821 AW376684 AW376623 AW376622
		BE706047 AW752602 AW752691 AW752674 AW752652 AA379167 AW752610 AW752684
		AW752613 AW752660 AW848709 AW848576
		AW849155 AW848981 AW848980 AW848979 AW848978 AW848973 AW848916 AW848713
		AW848708 AW848642 AW848641 AW848639
		AW848573 AW848493 AW848492 AW848489 AW848488 AW848487 AW848353 AW848352
		AW848220 AW752698 AW752697 AW752682
		AW752681 AW752680 AW752679 AW752664 AW752651 AW752638 AW752637 AW752636
		AW752628 AW752626 AW752624 AW752619
		AW752596 AW752608 AL582019 BE875587 AL529175 AW965868 BG686208 AA259073
		BE696973 AA459543 AA358314 W40564 BF926427
		AW849000 AW848718 AW848515 AW848507 AW848444 AW848440 AW848232 AW848222
		AW752657 AW376786 AW376781 AW376615
		AW376614 BI752581 AA534520 AI748906 AA047799 AI014753 AL514460 AL581982
		BG743146 W24171 H20102 H11227 AW752607 AW006596
		AW130378 BE716519 AW752661 AW848289 BF349557 AW752612 AW752632 AW848910
		NM_004077 AF047042 AL560606 BI765896
		BI196831 BI855656 BE906674 BG749937 BE535486 BE019810 AA313713 AA992542
		AA332541 AA682985 AA356125 BE140478 BG750945
		BI457548 BG025661 BF326302 AA325019 BG980676 AA337465 AA321974 BG949285
		BG427585 R23979 BG611485 BE560678 W16977
		N50379 BG824101 BG471750 BI463171 W04691 AU099360 BG471590
		BM011999 BE262945 BE559801 BF756438 BE881957 BE314546
		BG911831 BG150811 BG112017 AA157518 T92368 AW752620
433070	22399_1	BE794397 BG121933 BI194378 AW410585 AW954321 BI045952 AW024741
		AW444579 AI973044 AI075432 AI093319 AI635673 AA625246
		D45465 BE173394 AV724875 AW954889 AI366776 AI498872 AA027096 AI351434 AA916072
		AA302868 AA535890 AI420076 AI669179
		AI240010 AI201405 AW451691 AA317478 AA424952 AW772292 BE857671
		AI869583 AI470411 AI804946 AI744155 D80532
455968	1557068_1	BE168828 BE168823 BE168830 BE168820 BE168931 BE168826 BE168928
459235	26808_3	AW814516 AW815927 AW814504 BF375203 AW814522 AW814521
		AW814524 BF375206 AW814518 AW814517 AI940652 BF837881
		AW751232 BF374342 AW176453 AW814505 BF886651
		AW814525 BG001382 BE933380
449713	519163_1	AW027025 AW028264 AI660390
429446	352_30	AI547111 BG945630 BG913104 AA558007 AW973749
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0359]

TABLE 8C
Pkey	Ref	Strand	Nt_position
405278	6139075	Minus	3863-3965, 4823-4891,
			5439-5529, 6043-6170
404501	7229859	Minus	37270-37526
401149	7229925	Plus	73117-74019
402273	2979528	Plus	28990-29203, 32299-32402,
			32474-32668
402517	9798106	Plus	17569-17721
401553	8099284	Minus	83990-84161
404958	7407941	Minus	2731-4531
403324	8440025	Minus	107104-107309
401913	9369520	Minus	33753-33904
403794	8096910	Plus	163292-163884
403180	7523976	Minus	63603-63759
402651	7960391	Plus	174215-174380
404359	7630876	Minus	11789-12516
402889	9931133	Plus	89392-89498, 90358-90571
403796	8099896	Minus	75073-77664
404473	8079921	Plus	22639-22773
402023	7528158	Minus	132872-133040
404518	8151988	Plus	84494-84603
403579	8101179	Minus	36167-36365
403545	8078400	Plus	25293-25640
406060	6899623	Minus	20339-20746
405600	5923640	Plus	26662-27225
405502	9211311	Minus	50360-50584
403582	8101186	Plus	18308-18458
400818	8569994	Plus	172644-172765, 173085-173200
405443	7408143	Plus	90716-90887, 101420-101577
402878	9908870	Minus	56133-56522
404046	3688074	Minus	2-773
402012	7407997	Minus	111771-111909, 112107-112226,
			112519-11269
402124	4033680	Plus	164206-164459
402608	9910096	Plus	37495-37669
402022	7139714	Plus	165595-165748
401376	7417809	Plus	40584-40963
402364	9454515	Minus	54983-55240, 56507-56785,
			56982-57365
401942	4982556	Minus	130749-131044
406140	9168231	Minus	49887-50219
401522	7717114	Minus	154437-154847, 155420-155505,
			155568-15615
401346	9926605	Minus	12031-13032
403750	7229814	Minus	133638-134110
402441	9796503	Plus	140903-141106
404126	9796876	Plus	48919-49155
404187	4481839	Plus	7644-7991
404752	7109522	Minus	120168-120326
401405	7768126	Minus	69276-69452, 69548-69958
406210	7341959	Plus	58546-58687
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0360] Table 9A lists about 100 genes up-regulated in Hepatitis C positive liver tissues from patients that are non-responsive to pegylated-interferon-alpha plus ribavirin treatment (non-responders) compared to Hepatitis C positive liver tissues from patients that are responsive to the treatment (responders). In both cases, the liver biopsies were obtained prior to treatment. The 100 genes have the potential to be diagnostics and/or prognostic markers for determining the responsiveness of Hepatitis C infected liver tissues to pegylated-interferon-alpha plus ribavirin treatment. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of non-responders to the “weighted average” of responders was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the non-responders was set to the trimean of several different non-responders. The “weighted average” of the responders was set to the either 10 or the trimean of several different responders, whichever value was greater to eliminate ratios with a denominator of zero or less.

TABLE 9A
Pkey	ExAccn	UniGene	UnigeneID	R1	R2
444342	NM_014398	Hs. 10887	similar to lysosome-associated membrane	2.34E−02	5.21
431326	AW970580	Hs. 198689	KIAA0728 protein	2.34E−02	4.92
424017	AA333789		gb: EST37925 Embryo, 9 week Homo sapiens	5.29E−02	4.82
410099	AA081630		KIAA0036 gene product	1.13E−02	4.77
407360	X13075		gb: Human 2a12 mRNA for kappa-immunoglobu	6.19E−02	4.52
447514	AI809314	Hs. 208501	ESTs, Weakly similar to B34087 hypotheti	8.30E−02	4.52
437233	D81448	Hs. 339352	Homo sapiens brother of CDO (BOC) mRNA,	1.34E−02	4.47
454525	BE280421	Hs. 94499	ESTs	4.53E−02	4.47
452455	N25153		ESTs, Weakly similar to AF174605 1 F-box	2.31E−02	4.45
458393	AI792868	Hs. 135365	ESTs	8.24E−02	4.30
458026	H12028	Hs. 6396	jumping translocation breakpoint	1.63E−02	4.20
459171	AW967801	Hs. 151293	ESTs, Weakly similar to T42705 hypotheti	4.55E−02	4.17
426798	AA385062	Hs. 130260	ESTs	8.27E−02	4.13
447339	AI770001	Hs. 209445	ESTs	4.55E−02	4.10
447686	AI939440		ESTs	9.52E−02	4.10
433312	AI241331	Hs. 131765	ESTs, Moderately similar to I38937 DNA/R	3.29E−02	4.09
435391	AA704588	Hs. 58934	ESTs	5.29E−02	4.05
437994	U92012	Hs. 251659	ESTs, Weakly similar to mariner transpos	3.83E−02	4.00
437990	AI686579	Hs. 121784	ESTs	7.15E−02	3.97
406355			C5000598: gi|2136258|pir||I59377 template	8.30E−02	3.95
401745			Target Exon	2.34E−02	3.92
435903	AA701890	Hs. 118163	ESTs	4.43E−02	3.92
407366	AF026942	Hs. 17518	gb: Homo sapiens cig33 mRNA, partial sequ	1.64E−02	3.80
442269	AI797066	Hs. 201995	ESTs	1.10E−02	3.75
452941	AL110347	Hs. 31074	N-sulfoglucosamine sulfohydrolase (sulfa	5.11E−03	3.72
455604	BE011183		gb: PM3-BN0218-100500-003-d09 BN0218 Homo	4.55E−02	3.58
401376			Target Exon	8.27E−02	3.55
456445	AK000735	Hs. 93581	hypothetical protein FLJ10512	3.86E−02	3.52
416814	AW192307	Hs. 80042	dolichyl-P-Glc: Man9GlcNAc2-PP-dolichylgl	8.30E−02	3.50
444640	AL133933	Hs. 64310	interleukin 11 receptor, alpha	3.27E−02	3.48
445882	AI948717	Hs. 225155	ESTs, Weakly similar to A46302 PTB-assoc	6.17E−02	3.42
453471	AL037887	Hs. 208179	ESTs	8.30E−02	3.42
449756	W16700	Hs. 94542	ESTs	8.27E−02	3.42
437774	AW978199	Hs. 291648	ESTs, Weakly similar to I38022 hypotheti	6.17E−02	3.30
437929	T09353	Hs. 106642	ESTs, Weakly similar to T09052 hypotheti	6.19E−02	3.30
405513			ENSP00000241075: TRRAP PROTEIN.	7.15E−02	3.28
404098			Target Exon	8.27E−02	3.25
408570	AL046406	Hs. 103483	KIAA1798 protein	7.12E−02	3.22
426101	AL049987		Homo sapiens mRNA; cDNA DKFZp564F 112 (fr	4.55E−02	3.22
447164	AF026941	Hs. 17518	vipirin; similar to inflammatory respon	8.30E−02	3.20
401242			mitogen-activated protein kinase 8 inter	4.55E−02	3.10
435154	AA668764		ESTs	8.30E−02	3.10
449137	AW134478	Hs. 196033	ESTs	3.32E−03	3.05
448497	BE613269	Hs. 21893	hypothetical protein DKFZp761N0624	2.31E−02	3.02
410541	AA065003	Hs. 64179	syntenin-2 protein	8.30E−02	3.02
405723			Target Exon	8.30E−02	3.00
449613	N63808	Hs. 34299	ESTs	2.76E−02	3.00
459697	AA406062	Hs. 98002	ESTs	7.59E−03	3.00
417958	AA767382	Hs. 193417	ESTs	8.27E−02	2.97
444736	AA533491	Hs. 23317	hypothetical protein FLJ14681	9.49E−02	2.96
417042	C75563	Hs. 113029	ribosomal protein S25	6.14E−02	2.92
403512			C3000579*: gi|12643308|sp|Q9Y4K1|AIM1_HUM	7.66E−03	2.92
404226			Target Exon	4.53E−02	2.90
443884	N20617	Hs. 194397	leptin receptor	8.30E−02	2.88
432222	AI204995		gb: an03c03.x1 Stratagene schizo brain S1	8.30E−02	2.88
407284	AI539227	Hs. 214039	hypothetical protein FLJ23556	6.19E−02	2.86
439737	AI751438	Hs. 41271	Homo sapiens mRNA full length insert cDN	2.34E−02	2.83
408503	AW119059		ESTs, Weakly similar to T12552 hypotheti	8.30E−02	2.80
419743	AW408762	Hs. 5957	Homo sapiens clone 24416 mRNA sequence	8.30E−02	2.77
456727	BE350986	Hs. 33254	hypothetical protein FLJ21817 similar to	1.11E−02	2.75
440409	AW294316	Hs. 125608	ESTs	3.27E−02	2.73
408891	NM_006577	Hs. 284284	ESTs, Highly similar to beta-1,3-N-acety	4.53E−02	2.70
430291	AV660345	Hs. 238126	CGI-49 protein	2.34E−02	2.66
410851	AW612147	Hs. 32058	Homo sapiens C1orf19 mRNA, partial cds	7.15E−02	2.65
414737	AI160386	Hs. 125087	ESTs	3.86E−02	2.65
422744	AW268803	Hs. 119640	hBKLF for basic kruppel like factor	5.24E−02	2.60
429867	AW204372		tomosyn	5.19E−02	2.56
431926	AW972724		gb: EST384816 MAGE resequences, MAGL Homo	5.29E−02	2.55
430259	BE550182	Hs. 127826	RalGEF-like protein 3, mouse homolog	3.35E−03	2.54
428558	AI587502		ESTs	9.52E−02	2.53
435145	AI277259	Hs. 116631	ESTs	2.76E−02	2.52
403436			NM_006548*: Homo sapiens IGF-II mRNA-bind	8.30E−02	2.52
447698	AI420156	Hs. 326733	ESTs	7.15E−02	2.52
407339	AA777542	Hs. 132670	ESTs	2.76E−02	2.50
410401	AW673335	Hs. 259641	ESTs	2.34E−02	2.50
418481	M81945		CD34 antigen	3.29E−02	2.50
430654	AW970081	Hs. 325603	ESTs	8.27E−02	2.50
433102	AI343966	Hs. 158528	ESTs	1.13E−02	2.44
442191	W95186	Hs. 8136	endothelial PAS domain protein 1	3.86E−02	2.42
447384	AI377221	Hs. 40528	ESTs	7.15E−02	2.40
430552	AA176374	Hs. 243886	nuclear autoantigenic sperm protein (his	6.14E−02	2.38
444811	AW137791	Hs. 148419	ESTs	1.64E−02	2.37
435519	AI218950	Hs. 125461	hypothetical protein FLJ11539	5.29E−02	2.37
435675	AA694099	Hs. 266820	ESTs	8.30E−02	2.36
402305			C19000735*: gi|4508027|ref|NP_003414.1|z	1.12E−02	2.35
438084	AW516099	Hs. 121925	ESTs	8.30E−02	2.32
450747	AI064821	Hs. 318535	ESTs, Highly similar to 1818357A EWS gen	7.15E−02	2.32
452032	BE244005	Hs. 27610	retinoic acid-and interferon-inducible	8.27E−02	2.25
455751	BE075281		gb: PM1-BT0585-290200-005-d07 BT0585 Homo	8.10E−02	2.21
427471	AA403131	Hs. 266782	KIAA1826 protein	8.30E−02	2.20
437210	AA311443	Hs. 293563	Homo sapiens mRNA; cDNA DKFZp586E2317 (f	6.19E−02	2.17
458025	AI275406	Hs. 32450	gb: ql63c10.x1 Soares_NhHMPu_S1 Homo sapi	2.76E−02	2.17
444830	AI198854	Hs. 145437	ESTs	6.17E−02	2.12
455086	AW855386		gb: CM3-CT0275-191099-024-d05 CT0275 Homo	8.30E−02	2.10
421904	BE143533	Hs. 109309	hypothetical protein FLJ20035	4.55E−02	2.07
414395	BE304888	Hs. 279834	EST	3.27E−02	2.02
404973			Target Exon	8.27E−02	2.01
428701	NM_013276	Hs. 190207	carbohydrate kinase-like	3.86E−02	2.01
436651	BE045962	Hs. 275998	ESTs	1.34E−02	2.00
448959	AI610343	Hs. 293267	ESTs	7.12E−02	2.00
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of non-responders over Trimean of responders Ratio

[0361]

TABLE 9B
Pkey	CAT Number	Accession
424017	888651_1	AW966107 AA334317 AA333789
410099	16732_1	AK055674 AW965247 AV751598 AA290926 R53043 AA331387 AK056148 BI917678
		BG819395 BG911971 BG820167 AI174254 AA348720
		AA364503 BG714279 AW893230 AA081774 H24222 AV727176 BF875715
		AA081630 BE000834 AA334880 AL563737 BG029709 W52882
		AI439658 BE551237 AA283724 BF109530 AI457096 AI805992 BE467736 AA693467
		AI697593 AI887863 AI167419 AW901980 AW901768
		BE702179 AA484549 T23811 BE327043 AA716027 AA917004 AA167714 BF339675
		AA084618 AI418634 T31586 AA436630 AI366472
		AA706191 AI422304 AI204899 AI041169 AA211402 AW827081 AA788593 T32736
		AI767935 AA747914 T03534 AW959843 AL119527
		BE327037 AW901982 AW993370 AW901977 AW902071 W60090 N79906 D52685
		T07735 BE702069 BE702172 T08671 BE767121 BE767117
		BE767113
452455	928588_1	BE877195 BG988071 AI902576 N25153 AW518714 N25154
447686	2958543_1	AI939440 AI424128 AI419682
455604	1478710_1	BE011183 BE011324 BE011170 BE011188 BE011181 BE011333 BE011169 BE011161
426101	3211_1	AL049987 BG620667 BG571984 AW362842 BE150456 BE326465
		AW872412 AA868553 AI024689 AA442638 AA813604 AA442648 AA663108
		AA442379 AA229448 N56349 AA460220 AW971193 AA453725 AI742087
		AI860142 AW769479 AI917507 AI860141 BE045272 AW277065
		AI921333 AI354470 BE466760 AI827987 AI005467 AA833517 AA563934
		AA522837 AA812876 AW020895 AA600372 AA663178 AI187977
		AA229164 AW270324 AA703066 T78981 AA632986 BE708493 R31132 AI253986
		AI916737 T84796 T84294 AW961515 AI459289 BF109829
		BI491853 AI084517 AW103830 BE835233 A1472712 AV741009 AA551512
		N28268 AA436880 AA447794 BE835410 BE835385 BE818352
		BE818350 R64648 BE646467 AA493776 AA437299 BE818343 R95914 R31089
		BF576826 AU186065 BF802058 AI217018 AA247541 AI191725
		BE766918
435154	126605_1	AW972063 AA668764 AA804491 AW665688 AA765069
432222	539529_1	BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354
408503	24663_2	NM_054110 BC014789 BI552129 BG896227 BG900557 AY035399 AW119059
		BF432376 AW629242 AA971319 AI378176 AI275884 AA236602
		BG898257 BG897636 BG900588 AF361251 BG926353 BG714178
		AA368180 BG896473 BG715977 BG900230 BG901163 BF342939
429867	1003_2	BE467551 AI214965 AW204372
431926	1237041_1	AW972724 AA877998 AA522631 AU185388
428558	1382530_1	AA430150 AA888768 AI587502
418481	17381_1	S53911 NM_001773 AL572644 AL550179 AI688653 AW025002 AW614285
		AU158779 AI017002 AA434387 AI252665 AI262206 AU147582
		AI144193 AW952860 AI128776 AI017793 AI160509 AA906021 AI149563
		AU154950 AI128488 W74409 AI970362 AI141453 AU158772 W58493
		BM148338 R73091 AW020496 BI491517 AA022917 AI432610 AI879448
		R69099 AI708954 AW014274 AA483672 AA528783 AA912271
		AI926942 BE677587 AI874217 AA152376 AA640408 AI287334 BF830285
		AA311473 C18678 AA922603 C00910 AI124073 R38730 AA043439
		W94644 W58646 AA664247 BE061934 H01096 R69613 AI383162 AU133723
		AA311526 R67942 H01097 H72113 R72430 R39494 AV744074
		AA535925 BI759288 BI052385 BF854687 AW608286 AA043438 R72478
		AL513811 R69214 AA188435 AA054965
455751	1497052_1	BE075281 BE075119 BE075123 BE075219 BE075046
455086	1095746_1	AW855553 AW855417 AW855386
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0362] Table 10A lists about 149 genes up-regulated in Hepatitis C positive liver tissues from patients that are responsive to pegylated-interferon-alpha plus ribavirin treatment (responders) compared to Hepatitis C positive liver tissues from patients that are not responsive to the treatment (non-responders). In both cases, the liver biopsies were obtained prior to treatment. The 149 genes have the potential to be diagnostics and/or prognostic markers for determining the responsiveness of Hepatitis C infected liver tissues to pegylated-interferon-alpha plus ribavirin treatment. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the Wilcoxon rank-sum test p-value between the 2 groups was less than 0.10, the ratio of the “weighted average” of responders to the “weighted average” of non-responders was equal to or above 2.0, and that the differences between the same 2 groups was equal to or above 30.0. The “weighted average” of the responders was set to the trimean of several different responders. The “weighted average” of the non-responders was set to the either 10 or the trimean of several different non-responders, whichever value was greater to eliminate ratios with a denominator of zero or less.

TABLE 10A
Pkey	ExAccn	UniGene	Unigene Title	R1	R2
400301	X03635	Hs. 1657	estrogen receptor 1	5.11E−03	8.42
440700	AW952281	Hs. 296184	guanine nucleotide binding protein (G pr	1.63E−02	6.41
421911	AL041520		gb: DKFZp434G2317_s1 434 (synonym: htes3)	3.27E−02	5.67
400302	N48056	Hs. 283946	folate hydrolase (prostate-specific memb	2.34E−02	5.61
414559	AV656184	Hs. 76452	C-reactive protein, pentraxin-related	3.86E−02	5.60
418363	AA218628	Hs. 202977	ESTs	8.30E−02	5.50
427450	AB014526	Hs. 178121	KIAA0626 gene product	1.63E−02	5.29
404354			Target Exon	1.64E−02	5.05
436674	AA725002	Hs. 272018	low molecular mass ubiquinone-binding pr	8.30E−02	5.00
455191	AW864547		gb: PM4-SN0016-120500-003-b12 SN0016 Homo	6.17E−02	4.90
415374	F06904	Hs. 8346	ESTs	6.19E−02	4.83
404483			C8000657*: gi|1504040|dbj|BAA13219.1|(D8	1.13E−02	4.77
444813	AW054834	Hs. 210356	ESTs	8.30E−02	4.77
401197			ENSP00000229263*: HSPC213.	8.27E−02	4.75
449959	AI076834	Hs. 21160	ESTs	2.76E−02	4.60
444402	AL138436	Hs. 49359	hypothetical protein DKFZp547E052	2.30E−02	4.57
451898	T92572	Hs. 142019	ESTs, Weakly similar to 1207289A reverse	1.64E−02	4.55
457231	AI472022	Hs. 301959	praline synthetase co-transcribed (bacte	4.55E−02	4.52
413303	AW836130	Hs. 75277	hypothetical protein FLJ3910	8.20E−02	4.40
435147	AL133731	Hs. 4774	Homo sapiens mRNA; cDNA DKFZp761C1712 (f	6.19E−02	4.40
442552	R20624		son of sevenless (Drosophila) homolog 1	6.19E−02	4.40
401635			C11000702: gi|10048448|ref|NP_065258.1|g	9.52E−02	4.27
430048	T65054	Hs. 73605	ESTs	8.27E−02	4.27
406570			NM_024889*: Homo sapiens hypothetical pro	2.34E−02	4.17
433122	AB019391	Hs. 58049	ESTs	7.15E−02	4.13
431940	H06075	Hs. 270232	ESTs	3.35E−03	4.07
411047	AW938479		gb: CM0-DT0057-290200-253-h06 DT0057 Homo	8.27E−02	4.04
403609			C3001199: gi|7494834|pir||T15308 hypothet	3.29E−02	4.00
430165	AW849764	Hs. 314330	ESTs	3.25E−02	4.00
443935	NM_000236	Hs. 9994	lipase, hepatic	9.52E−02	3.98
458875	AA814517	Hs. 321775	hypothetical protein DKFZp434D1428	1.13E−02	3.96
403686			C4001366*: gi|9837427|gb|AAG00570.1|AF287	5.29E−02	3.95
403767			Target Exon	7.15E−02	3.95
401114			Target Exon	4.55E−02	3.89
412286	AW935866		gb: QV3-DT0019-120100-055-b04 DT0019 Homo	2.33E−02	3.88
417505	T73280	Hs. 193228	alanine-glyoxylate aminotransferase 2	6.19E−02	3.85
440798	AB020648	Hs. 7426	KIAA0841 protein	3.29E−02	3.85
403743			C1002604: gi|8393668|ref|NP_058989.1|kin	8.30E−02	3.81
429031	BE002237	Hs. 239666	Homo sapiens cDNA FLJ13495 fis, clone PL	6.17E−02	3.79
453815	AL135365	Hs. 126857	Homo sapiens cDNA FLJ12936 fis, clone NT	3.29E−02	3.77
423983	AA333261		gb: EST37476 Embryo, 8 week 1 Homo sapien	4.55E−02	3.75
405206			Target Exon	7.12E−02	3.72
425057	AA826434	Hs. 1619	achaete-scute complex (Drosophila) homol	4.55E−02	3.72
446847	T51454	Hs. 82845	Homo sapiens cDNA: FLJ21930 fis, clone H	4.55E−02	3.71
414535	W27834	Hs. 333417	capping protein (actin filament) muscle	8.13E−02	3.70
456250	U09196	Hs. 82520	polymerase (DNA-directed), delta 4	9.52E−02	3.69
446885	T74107	Hs. 122613	ESTs	2.31E−02	3.67
409313	NM_001325	Hs. 693	cleavage stimulation factor, 3′pre-RNA,	2.33E−02	3.65
441159	AI198604	Hs. 126682	ESTs	4.53E−02	3.63
422519	AA347877	Hs. 122730	ESTs	5.29E−02	3.63
435545	AA687415	Hs. 28107	ESTs	1.12E−02	3.63
439910	H66765	Hs. 339397	ESTs	2.34E−02	3.55
458991	AI743502		gb: wf63h12.x2 Soares_NFL_T_GBC—	8.30E−02	3.54
			S1 Homo s
403789			NM_001334*: Homo sapiens cathepsin O (CTS	8.30E−02	3.52
433156	R59206	Hs. 17519	Homo sapiens cDNA: FLJ22539 fis, clone H	3.29E−02	3.52
404902			NM_025213: Homo sapiens spectrin, beta, n	5.29E−02	3.50
436499	AJ276678	Hs. 283102	HEF like Protein	5.29E−02	3.50
424092	AI085286	Hs. 133476	ESTs	6.19E−02	3.38
458443	AV647010	Hs. 27	glycine dehydrogenase (decarboxylating;	1.63E−02	3.35
446681	AJ003624	Hs. 15896	kendrin	4.55E−02	3.32
401778			MCT-1 protein	8.30E−02	3.25
402244			C19000767*: gi|4508027|ref|NP_003414.1|z	6.19E−02	3.23
419287	X91906	Hs. 89872	chloride channel 5 (nephrolithiasis 2, X	1.64E−02	3.22
405543			C2002468*: gi|3334856|emb|CAA11279.1|(AJ	8.17E−02	3.20
429624	AA458648	Hs. 99476	ESTs, Weakly similar to 1313184B alpha 1	8.27E−02	3.18
453751	R36762	Hs. 101282	Homo sapiens cDNA: FLJ21238 fis, clone C	4.55E−02	3.17
404511			NM_004349: Homo sapiens core-binding fact	1.35E−02	3.13
445159	AI631036	Hs. 196843	ESTs	3.27E−02	3.10
457565	BE294029	Hs. 279903	Ras homolog enriched in brain 2	3.29E−02	3.10
404717			NM_007313*: Homo sapiens v-abl Abelson mu	6.19E−02	3.07
403920			suppressor of potassium transport defect	3.29E−02	3.07
445664	AW968638	Hs. 237691	ESTs, Weakly similar to KIAA0601 protein	5.27E−02	3.05
403442			Target Exon	6.19E−02	3.02
436336	AJ011378		ESTs	4.41E−02	3.00
446783	AW138343	Hs. 141867	ESTs	1.64E−02	2.97
451790	AA927403	Hs. 3803	reticulon 2	8.30E−02	2.96
427958	AA418000	Hs. 98280	potassium intermediate/small conductance	1.62E−02	2.92
430989	AB009249	Hs. 248192	fibroblast growth factor 17	8.27E−02	2.91
425744	AA362985		gb: EST72769 Ovary II Homo sapiens cDNA 5	8.30E−02	2.91
419511	AA429750	Hs. 75113	general transcription factor IllA	4.55E−02	2.89
446001	AI827473		ESTs	6.19E−02	2.88
442602	R46488	Hs. 187497	ESTs	4.50E−02	2.85
443589	H52931	Hs. 165067	ESTs	8.27E−02	2.85
457142	AI924353	Hs. 290969	EST	7.59E−03	2.83
404956			C1003210*: gi|6912582|ref|NP_036524.1|pe	3.27E−02	2.83
426181	AA371422	Hs. 334371	hypothetical protein MGC13096	6.19E−02	2.83
454086	AW885909	Hs. 279789	PRO1073 protein	6.19E−02	2.82
450770	AA019924	Hs. 28803	ESTs	8.30E−02	2.81
452357	AI638176	Hs. 283865	ESTs	6.19E−02	2.80
456758	AA325170	Hs. 224627	ESTs, Weakly similar to FAHUAA alpha-act	6.17E−02	2.79
409959	BE349470		mucin 6, gastric	1.11E−02	2.77
417674	R07915	Hs. 20039	ESTs	6.19E−02	2.75
446548	AI769392	Hs. 200215	ESTs	8.30E−02	2.75
407988	N47760	Hs. 285107	hypothetical protein FLJ13397	9.24E−03	2.70
435236	T03890	Hs. 157208	ESTs, Highly similar to ARX MOUSE HOMEOB	9.52E−02	2.69
447090	AI361114	Hs. 270711	ESTs	7.59E−03	2.67
451068	AW294432	Hs. 144252	ESTs	3.29E−02	2.63
431668	AW969610	Hs. 151179	ESTs	3.29E−02	2.63
449000	U69560	Hs. 3826	kelch-like protein C3IP1	9.17E−03	2.63
443832	AI829610	Hs. 23531	ESTs	8.27E−02	2.62
405481			Target Exon	7.15E−02	2.60
438922	R71288	Hs. 259664	ESTs	4.53E−02	2.60
402168			NM_022046*: Homo sapiens kallikrein 14 (K	1.95E−02	2.59
444280	AI380835	Hs. 148505	ESTs	3.27E−02	2.58
435471	AA682544		ESTs	4.55E−02	2.58
452137	AI861840	Hs. 211687	ESTs	2.76E−02	2.58
424049	AB014524	Hs. 138380	KIAA0624 protein	1.62E−02	2.55
418154	BE165866		nuclear receptor subfamily 1, group I, m	6.19E−02	2.52
447113	AA741545	Hs. 282832	ESTs, Weakly similar to T24961 hypotheti	1.13E−02	2.50
439389	AA318940	Hs. 56004	ESTs	3.77E−02	2.48
442049	AA310393	Hs. 190044	ESTs	7.15E−02	2.47
445119	AF035121	Hs. 12337	kinase insert domain receptor (a type II	1.12E−02	2.47
454341	AI654712	Hs. 54424	hepatocyte nuclear factor 4, alpha	4.48E−02	2.45
420028	AB014680	Hs. 8786	carbohydrate (N-acetylglucosamine-6-O) s	4.55E−02	2.45
420556	AA278300	Hs. 124292	Homo sapiens cDNA: FLJ23123 fis, clone L	6.19E−02	2.45
456558	BE410992	Hs. 258730	heme-regulated initiation factor 2-alpha	6.17E−02	2.45
423954	AW753164	Hs. 288604	KIAA1632 protein	8.30E−02	2.43
450565	T72234	Hs. 193228	alanine-glyoxylate aminotransferase 2	5.29E−02	2.40
446068	AL049801	Hs. 13649	Novel human gene mapping to chomosome 13	5.27E−02	2.39
419662	W87674		gb: zh66a01.r1 Soares_fetal_liver_spleen—	1.55E−02	2.38
432547	BE350533	Hs. 306418	Homo sapiens cDNA FLJ10958 fis, clone PL	6.19E−02	2.38
403440			Target Exon	4.55E−02	2.37
407625	AA148766	Hs. 293885	hypothetical protein FLJ14902	2.33E−02	2.35
415770	M79237		gb: EST01385 Subtracted Hippocampus, Stra	7.59E−03	2.34
433224	AB040919	Hs. 210958	KIAA1486 protein	4.53E−02	2.32
421573	AI302850	Hs. 262455	ESTs	5.29E−02	2.30
459283	NM_016940	Hs. 34136	chromosome 21 open reading frame 6	4.55E−02	2.26
424602	AK002055	Hs. 151046	hypothetical protein FLJ11193	8.30E−02	2.25
406180			small inducible cytokine subfamily A (Cy	3.29E−02	2.24
404810			Target Exon	8.30E−02	2.24
457841	AI678031	Hs. 122813	ESTs, Weakly similar to ZN22_HUMAN ZINC	8.30E−02	2.24
458492	AI143655		ESTs	2.76E−02	2.22
443708	AI082689	Hs. 63970	ESTs	2.31E−02	2.21
444758	AL044878	Hs. 11899	3-hydroxy-3-methylglutaryl-Coenzyme A re	8.30E−02	2.21
454302	AA306105	Hs. 50785	SEC22, vesicle trafficking protein (S. c	5.29E−02	2.20
456400	W28090		gb: 41h3 Human retina cDNA randomly prime	6.19E−02	2.20
408568	AW448965	Hs. 270087	ESTs, Weakly similar to I39295 X-linked	8.30E−02	2.18
444073	H68409	Hs. 38715	ESTs	8.27E−02	2.15
404437			C1000815: gi|9653274|gb|AAF27628.2|AF2175	8.30E−02	2.14
453315	BE544203	Hs. 24831	ESTs	6.19E−02	2.13
408931	AA251995	Hs. 334648	poly(A) polymerase alpha	8.30E−02	2.10
433444	AW975324	Hs. 129816	ESTs	4.55E−02	2.09
446226	AW889132	Hs. 11916	ribokinase	4.55E−02	2.08
452266	AI767250	Hs. 201446	ESTs	8.30E−02	2.05
436869	NM_014867	Hs. 5333	KIAA0711 gene product	3.86E−02	2.04
433906	AI167816	Hs. 43355	ESTs	5.29E−02	2.02
402370			Target Exon	8.30E−02	2.02
434306	AW081757	Hs. 44241	Homo sapiens cDNA: FLJ21447 fis, clone C	6.19E−02	2.01
422721	R41154	Hs. 275711	hypothetical protein MGC2452	6.19E−02	2.01
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: Wilcoxon rank-sum test p-value
R2: Trimean of responders over Trimean of non-responders Ratio

[0363]

TABLE 10B
Pkey	CAT Number	Accession
421911	863300_1	AL041520 AA300086
455191	1107840_1	AW864356 AW864547 AW864277 AW864496
442552	3248_3	BE566571 BE143063 BF367361 AW954369 AA412572 W95547 BE005367
		AA374200 AI769772 AA809852 AI918702 AW025682 AI272033
		AA713679 AI638383 Al364631 AW518885 N51823 AA256588 N47774 BE707161
		BF980035 AI628605 AW292949 BE350976 AW263078 AI885558
		AI261878 BE671974 N51071 AI695006 BM264289 BG055084 AI922512 AA633530 BM263987
		N56889 AW075473 BE700841 AW023886 BF527967
		AW591478 BE669905 N51720 AA806021 AA846566 W95290 AI453800 AI783684 AI417702 AW086132
		BE552047 AA227699 AW076131 AI126790
		AI654491 H01465 BF437982 AA400937 R20624 BF825527 H02691 W56480 BF944773
		R21195 R82844 H02596 BE243273 H50040
411047	1067666_1	AW850678 AW938479 AW814826
412286	210181_1	AW935866 BE069200 BF838900 BG989737 BG989811 BF833185 BF837808
423983	888204_1	AA333365 AA552870 AA333261
458991	3076691_1	AI743502 AI807438
436336	53728_1	AJ011378 AA416944 AA469902 AI015437
425744	320952_2	AW963337 AA362985 T27244
446001	647827_1	AI827473 AW510751 AW182908 AI269760
409959	2781_3	AW513804 BE179199 BE179195 BE179198 BE179204 BE162686
435471	131589_1	AA682544 AI248010 AA703577
418154	23972_1	X56199 AU119734 AW967136 W38705 W90159 AW444647 BF094079
		BE694692 AA339496 AA029093 BG925977 AA401072 AA348138 N90874
		BF055081 BF111983 BF091812 AI399764 BE931041 BF999882 BF352250
		BI049436 AA010244 AW374411 H52942 BF364437 AL538880
		AU137031 BE218742 BE175700 BE708041 AV651847 AV649491 AV649227
		AV649164 AV698455 AV651656 M78602 BF910285 AA333298 H75493
		AA332039 BM463335 AL603109 BF753137 BF083242 AI309717 AI349651
		BE174377 AW361207 BE159533 AL603126 BI003025 AA319706
		AW903950 AU118470 AU135122 AI811901 AA401166 BE165866 BE165832
		AA319621 BF749419 AI903726 BE833899 BI061305 BI061311 H78857
		BF912227 BF912224 AV747164 AA126644 W17094 T05342 AW374665 AA091968
		AA095633 BI009746 AL038020 BE010083 BE008038 BF808424
		BE010133 BF364245 BF328029 BE010189 AW903901 AW844209 AW879041 AL037999
		AV690829 AV693074 AV693056 AV690862 BE159515
		BE074613 AW905394
419662	2431548_1	W87872 W87674 W87774
415770	2051914_1	AA169260 AI267298 M79237
458492	2797412_1	AI869287 AI143655
456400	2391890_1	W27943 W28090
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0364]

TABLE 10C
Pkey	Ref	Strand	Nt_position
404354	7630858	Minus	115516-115702
404483	8096904	Minus	162212-163710
401197	9719705	Plus	176341-176452
401635	7145001	Minus	51895-52764
406570	3983519	Minus	88469-88570
403609	8308266	Minus	125974-126320
403686	7387348	Minus	66625-68364
403767	7767782	Plus	142903-143081
401114	9966554	Plus	52327-53385
403743	7652003	Minus	136463-136646
405206	6692345	Plus	17807-18338, 20430-20538
403789	8084957	Minus	64056-64148, 65262-65425
404902	7331453	Plus	36243-36358
401778	7249133	Minus	136881-137147, 137499-137628,
			137858-13814
402244	7690152	Plus	36938-38272
405543	9857582	Minus	104338-104449
404511	8151864	Minus	148501-148659
404717	9838068	Minus	165900-166052, 169415-169599,
			171430-17160
403920	7710868	Plus	40312-40490
403442	7210003	Plus	174560-175270
404956	7387343	Plus	55883-56203
405481	3688109	Plus	5718-5837, 8719-8818
402168	7458725	Minus	43245-43397
403440	9743372	Minus	34592-34661, 41940-42100
406180	7283201	Minus	38923-39107
404810	3702433	Minus	65278-65642
404437	5354481	Minus	17773-17938, 20263-20429
402370	9558580	Minus	14525-15733
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham. et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0365] Table 11A lists about 2410 genes up-regulated in Hepatitis C positive liver tissues compared to Hepatitis C negative liver tissues. These genes have the potential to be diagnostics and/or prognostic markers for Hepatitis C infected liver tissues. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the t-test p-value between the Hepatitis C positive liver tissues group and the Hepatitis C negative liver tissues was less than 0.01, and that the differences between the average “standardized values” of the different Hepatitis C positive liver tissues was equal to or above 1.0 more than the average standardized values of the different Hepatitis C negative liver tissues. The “standardized values” of the Hepatitis C liver tissues were derived by subtracting the median of the several different Hepatitis C negative liver tissue values from each probeset value, then divided by the interquantile range (IQR) of the same Hepatitis C negative liver tissue values.

TABLE 11 A
Pkey	ExAccn	UnigeneID	Unigene Title	R1	R2
413278	BE563085	Hs. 833	interferon-stimulated protein, 15 kDa	1.24E−10	13.42
447164	AF026941	Hs. 17518	vipirin; similar to inflammatory respon	1.68E−07	11.03
426312	AF026939	Hs. 181874	interferon-induced protein with tetratri	8.68E−10	9.84
431629	AU077025	Hs. 265827	interferon, alpha-inducible protein (clo	9.17E−13	9.06
422596	AF063611	Hs. 118633	2′-5′-oligoadenylate synthetase−like	4.59E−09	8.28
426711	AA383471	Hs. 343800	conserved gene amplified in osteosarcoma	3.15E−15	6.94
427579	AA366143	Hs. 179669	hypothetical protein FLJ20637	4.05E−09	6.76
409461	AA382169	Hs. 54483	N-myc (and STAT) interactor	5.26E−12	6.61
453779	N35187	Hs. 43388	28 kD interferon responsive protein	1.47E−11	6.48
418396	AI765805	Hs. 26691	ESTs	4.41E−08	6.33
433364	AI075407	Hs. 296083	ESTs, Moderately similar to I54374 gene	2.97E−15	6.27
414404	W16712		KIAA0306 protein	1.42E−06	6.25
455705	AW161061		ESTs, Weakly similar to zinc finger prot	5.43E−11	6.24
430478	NM_014349	Hs. 241535	apolipoprotein L, 3	3.88E−17	6.09
413880	AI660842	Hs. 110915	interleukin 22 receptor	5.13E−05	5.91
417621	AV654694	Hs. 82316	interferon-induced, hepatitis C-associat	2.55E−12	5.55
432680	T47364	Hs. 278613	interferon, alpha-inducible protein 27	2.59E−15	5.35
418622	AW971960	Hs. 236456	ESTs, Weakly similar to A46010 X-linked	9.09E−04	5.26
448569	BE382657	Hs. 21486	signal transducer and activator of trans	1.56E−15	5.00
421379	Y15221	Hs. 103982	small inducible cytokine subfamily B (Cy	9.16E−09	4.97
414004	AA737033	Hs. 7155	ESTs, Moderately similar to 2115357A TYK	3.33E−10	4.73
414760	BE298063	Hs. 77254	chromobox homolog 1 (Drosophila HP1 beta	3.99E−10	4.66
446217	AI651594	Hs. 99709	ESTs	2.36E−09	4.63
431620	AA126109	Hs. 264981	2′-5′-oligoadenylate synthetase 2 (69-71	4.54E−12	4.57
414737	AI160386	Hs. 125087	ESTs	4.78E−06	4.43
421904	BE143533	Hs. 109309	hypothetical protein FLJ20035	2.86E−10	4.36
402994			NM_002463*: Homo sapiens myxovirus (influ	7.92E−05	4.29
428467	AK002121	Hs. 184465	hypothetical protein FLJ11259	2.14E−04	4.28
409703	NM_006187	Hs. 56009	2′-5′-oligoadenylate synthetase 3 (100 k	4.28E−14	4.25
438154	AI671957	Hs. 19523	Homo sapiens clone 022f05 My030 protein	6.70E−09	4.13
437938	AI950087		gb: wq05c02.x1 NCI_CGAP_Kid12 Homo sapien	1.51E−08	4.08
432204	AI916132	Hs. 121593	Homo sapiens cDNA FLJ13123 fis, clone NT	6.22E−09	4.07
406659	AA663985	Hs. 277477	major histocompatibility complex, class	1.50E−06	4.06
406621	X57809	Hs. 8997	immunoglobulin lambda locus	1.85E−04	4.03
414915	NM_002462	Hs. 76391	myxovirus (influenza) resistance 1, homo	2.02E−12	4.03
435665	AI248952	Hs. 12320	ESTs	3.98E−07	4.01
442700	AA377618	Hs. 103834	hypothetical protein MGC5576	2.54E−07	3.96
410240	AL157424	Hs. 61289	synaptojanin 2	7.09E−06	3.95
447747	AW853144	Hs. 49203	ESTs	1.01E−03	3.88
452194	AI694413		Ubiquitin-like protein FAT10??? - diubiq	4.53E−08	3.85
409614	BE297412	Hs. 55189	hypothetical protein	1.22E−08	3.85
419071	AL137330	Hs. 301055	hypothetical protein DKFZp434F0272	7.16E−06	3.80
427283	AL119796	Hs. 174185	ectonucleotide pyrophosphatase/phosphodi	6.28E−07	3.78
437834	AA769294		gb: nz36g03.s1 NCI_CGAP_GCB1 Homo sapiens	9.13E−06	3.75
419200	AW966405		prefoldin 5	1.36E−09	3.75
419150	T29618	Hs. 89640	TEK tyrosine kinase, endothelial (venous	8.23E−04	3.74
434210	AA665612		ESTs	2.80E−10	3.73
427094	AB025254	Hs. 283761	tudor repeat associator with PCTAIRE 2	3.92E−10	3.71
407151	H25836	Hs. 301527	ESTs, Moderately similar to unknown [H. s	1.13E−09	3.69
427562	R56424	Hs. 134191	ESTs	1.84E−06	3.67
452690	AI536070	Hs. 15085	ESTs	5.53E−05	3.64
416126	R66415		gb: yh01a04.s2 Soares infant brain 1NIB H	7.65E−03	3.64
442439	U09759	Hs. 246857	mitogen-activated protein kinase 9	1.51E−07	3.62
443378	AW392550	Hs. 9280	proteasome (prosome, macropain) subunit,	4.69E−10	3.62
419550	D50918	Hs. 90998	KIAA0128 protein; septin 2	2.13E−10	3.57
451578	NM_016323	Hs. 26663	cyclin-E binding protein 1	1.88E−08	3.54
419438	AA406400	Hs. 12482	glyceronephosphate O-acyltransferase	2.63E−04	3.53
409899	U07418	Hs. 57301	mutL (E. coli) homolog 1 (colon cancer,	7.69E−05	3.51
441423	AI793299	Hs. 126877	ESTs	4.67E−06	3.50
409153	W03754	Hs. 50813	hypothetical protein FLJ20022	9.52E−06	3.50
448128	U71267	Hs. 20423	CCR4-NOT transcription complex, subunit	5.13E−09	3.48
409893	AW247090	Hs. 57101	minichromosome maintenance deficient (S.	1.21E−06	3.48
444342	NM_014398	Hs. 10887	similar to lysosome-associated membrane	7.46E−09	3.43
406906	Z25424		gb: H. sapiens protein-serine/threonine ki	5.22E−05	3.42
409512	AW979187	Hs. 293591	melanoma differentiation associated prot	7.83E−13	3.41
416844	AA299330	Hs. 1042	Sjogren syndrome antigen A1 (52 kD, ribon	3.64E−08	3.40
446452	AB018283	Hs. 15099	KIAA0740 gene product	3.88E−07	3.39
448111	AA053486	Hs. 20315	interferon-induced protein with tetratri	3.07E−11	3.39
400244			Eos Control	1.17E−09	3.36
433409	AI278802	Hs. 25661	ESTs	2.37E−03	3.33
408411	C15118	Hs. 322482	hypothetical protein DKFZp566J2046	2.97E−08	3.31
408393	AW015318	Hs. 23165	ESTs	6.98E−08	3.29
439971	W32474	Hs. 301746	RAP2A, member of RAS oncogene family	1.02E−08	3.28
453023	AW028733	Hs. 31439	serine protease inhibitor, Kunitz type,	7.29E−06	3.27
428706	AA432030	Hs. 265827	interferon, alpha-inducible protein (clo	1.46E−08	3.26
424865	AF011333	Hs. 153563	lymphocyte antigen 75	2.38E−06	3.22
422598	W93032	Hs. 325568	ESTs, Weakly similar to A46010 X-linked	9.27E−13	322
423436	R21176	Hs. 100926	ESTs	2.71E−03	3.21
418918	X07871	Hs. 89476	CD2 antigen (p50), sheep red blood cell	3.03E−09	3.20
438769	AA830684	Hs. 163426	ESTs	4.96E−05	3.19
458379	T78886	Hs. 284450	ESTs	2.70E−05	3.17
426572	AB037783	Hs. 170623	hypothetical protein FLJ11183	1.66E−03	3.15
419257	X53461	Hs. 89781	upstream binding transcription factor, R	7.32E−07	3.13
422746	NM_004484	Hs. 119651	glypican 3	7.65E−06	3.13
427657	AV652249	Hs. 180107	polymerase (DNA directed), beta	7.44E−12	3.10
433679	AA393968	Hs. 180145	HSPC030 protein	2.98E−04	3.09
418838	AW385224	Hs. 35198	ectonucleotide pyrophosphatase/phosphodi	3.18E−06	3.07
417678	X06560	Hs. 82396	2′,5′-oligoadenylate synthetase 1 (40-46	1.67E−09	3.06
428227	AA321649	Hs. 2248	small inducible cytokine subfamily B (Cy	3.03E−12	3.06
408989	AW361666	Hs. 49500	KIAA0746 protein	1.59E−06	3.03
410340	AW182833	Hs. 112188	hypothetical protein FLJ13149	3.80E−05	3.03
417389	BE260964	Hs. 82045	midkine (neurite growth-promoting factor	3.24E−07	3.01
423461	AB020527	Hs. 128827	solute carrier family 17 (sodium phospha	3.52E−06	3.00
411837	AW866282		gb: QV4-SN0024-080400-167-a03 SN0024 Homo	1.26E−03	3.00
427528	AU077143	Hs. 179565	minichromosome maintenance deficient (S.	1.35E−06	2.99
420058	AK001423	Hs. 94694	Homo sapiens cDNA FLJ10561 fis. clone NT	1.16E−06	2.99
432967	AA572949	Hs. 207566	ESTs	2.85E−03	2.98
415653	AA165400	Hs. 5321	hypothetical protein R33729_1	1.33E−04	2.95
419329	AY007220	Hs. 288998	S100-type calcium binding protein A14	1.31E−04	2.94
450937	R49131	Hs. 26267	ATP-dependant interferon response protei	1.74E−08	2.93
414617	AI339520	Hs. 288817	ESTs, Moderately similar to N Chain N, M	5.82E−05	2.92
450236	AW162998	Hs. 24684	KIAA1376 protein	1.00E−03	2.91
413179	N99692	Hs. 75227	Target CAT	2.78E−03	2.90
436746	AA730045	Hs. 187866	ESTs	1.29E−05	2.89
448879	Z44154	Hs. 22394	hypothetical protein FLJ10893	3.34E−06	2.88
414052	AW578849	Hs. 283552	ESTs, Weakly similar to unnamed protein	7.88E−08	2.87
408080	AW149754	Hs. 248652	ESTs, Weakly similar to T00273 hypotheti	5.99E−07	2.87
406990	S82075		gb: PA4 = candidate oncogene {3′region} [h	1.14E−05	2.86
409444	H47933	Hs. 33983	ESTs, Weakly similar to ALU6_HUMAN ALU S	6.32E−05	2.85
453883	AI638516	Hs. 347524	cofactor required for Sp1 transcriptiona	3.20E−09	2.85
434130	AL036067	Hs. 18925	protein x 0001	4.32E−05	2.84
408510	AA731642	Hs. 285017	hypothetical protein FLJ21799	8.74E−06	2.84
409231	AA446644	Hs. 692	GA733-2 antigen; epithelial glycoprotein	1.04E−04	2.83
448465	AW500269	Hs. 21264	KIAA0782 protein	8.90E−03	2.83
422440	NM_004812	Hs. 116724	aldo-keto reductase family 1, member B10	1.65E−03	2.83
432378	AI493046	Hs. 146133	ESTs	5.01E−07	2.82
432279	N95104	Hs. 274260	ATP-binding cassette, sub-family C (CFTR	8.30E−08	2.81
443119	AA312264	Hs. 7980	hypothetical protein MGC12966	6.95E−06	2.80
402264			NM_020657*: Homo sapiens zinc finger prot	4.15E−04	2.75
422112	BE540240	Hs. 111783	Lsm1 protein	3.36E−06	2.74
422553	AI697720	Hs. 171455	ESTs, Weakly similar to T31613 hypotheti	2.97E−05	2.74
432401	NM_013330	Hs. 274479	NME7	5.36E−05	2.73
442607	AA507576	Hs. 288361	Homo sapiens cDNA: FLJ22696 fis, clone H	4.35E−05	2.73
448550	AL161983	Hs. 21415	Homo sapiens mRNA; cDNA DKFZp761K2024 (f	2.37E−06	2.73
439237	AW408158	Hs. 318893	ESTs, Weakly similar to A47582 B-cell gr	5.16E−08	2.73
417308	H60720	Hs. 81892	KIAA0101 gene product	3.87E−07	2.71
433489	AW629150		ESTs	2.41E−04	2.68
433437	U20536	Hs. 3280	caspase 6, apoptosis-related cysteine pr	1.32E−07	2.67
452327	AK000196	Hs. 29052	hypothetical protein FLJ20189	1.23E−06	2.67
447880	AA214240	Hs. 301226	KIAA1085 protein	6.35E−08	2.65
430308	BE540865	Hs. 238990	cyclin-dependent kinase inhibitor 1B (p2	5.39E−08	2.65
431967	AJ243653	Hs. 283404	organic cation transporter	6.95E−03	2.62
425342	AA534073	Hs. 155751	voltage-dependent anion channel 3	2.81E−05	2.61
441737	X79449	Hs. 7957	adenosine deaminase, RNA-specific	1.72E−10	2.61
431939	AW008061	Hs. 231994	ESTs	1.34E−04	2.60
456463	AA380180	Hs. 56896	ESTs	3.87E−03	2.60
407756	AA116021	Hs. 38260	ubiquitin specific protease 18	1.46E−11	2.59
411060	NM_006074	Hs. 318501	Homo sapiens mRNA full length insert cDN	1.27E−12	2.58
435839	AF249744	Hs. 25951	Rho guanine nucleotide exchange factor	7.50E−03	2.57
413431	AW246428	Hs. 75355	(ubiquitin-conjugating enzyme E2N (homolo	4.19E−03	2.57
411605	AW006831		ESTs	1.58E−04	257
423545	AP000692	Hs. 129781	chromosome 21 open reading frame 5	7.99E−04	2.57
453917	BE297466	Hs. 36587	protein phosphatase 1, regulatory subuni	1.90E−06	2.57
429680	AL035754	Hs. 2474	toll-like receptor 1	9.61E−06	2.56
449718	AA459480	Hs. 23956	hypothetical protein FLJ20502	6.31E−07	2.56
433163	R40468	Hs. 163582	ESTs	1.53E−03	2.56
423753	Y11312	Hs. 132463	phosphoinositide−3-kinase, class 2, beta	1.90E−05	2.55
419082	AW953977	Hs. 78825	matrin3	3.07E−05	2.54
450698	W31489	Hs. 95044	ESTs, Weakly similar to I38022 hypotheti	8.19E−05	2.54
447400	AK000322	Hs. 18457	hypothetical protein FLJ20315	1.76E−10	2.54
426172	AA371307	Hs. 125056	ESTs	9.68E−06	2.54
431685	AW296135	Hs. 267659	vav 3 oncogene	1.05E−06	2.54
423617	AA741058	Hs. 20065	ESTs	3.05E−06	2.54
413670	AB000115	Hs. 75470	hypothetical protein, expressed in osteo	6.06E−08	2.53
449613	N63808	Hs. 34299	ESTs	4.88E−06	2.53
432388	X15218	Hs. 2969	v-ski avian sarcoma viral oncogene homol	2.62E−04	2.51
416795	AI497778	Hs. 20509	HBV pX associated protein-8	7.52E−05	2.51
409259	AW608930	Hs. 52184	hypothetical protein FLJ20618	1.37E−09	2.51
435017	AA336522	Hs. 12854	angiotensin II, type I receptor-associat	1.94E−08	2.51
420292	AW991781		gb: QV2-BN0007-280300-104-d06 BN0007 Homo	3.31E−03	2.51
410582	AW867197	Hs. 337561	hypothetical protein FLJ21616	5.40E−07	2.50
449478	AA829848	Hs. 193059	ESTs	3.55E−03	2.50
409346	AL162066	Hs. 54320	hypothetical protein DKFZp762D096	6.84E−08	2.50
418416	U11700	Hs. 84999	ATPase, Cu transporting, beta polypeptid	3.76E−08	2.49
448570	AI923944	Hs. 30913	ESTs	8.37E−06	2.47
418476	AA648431	Hs. 37883	hypothetical protein PNAS-131	6.13E−05	2.46
432710	AA609685	Hs. 278672	membrane component, chromosome 11, surfa	8.84E−08	2.45
442679	R53718		hypothetical protein FLJ10659	2.05E−07	2.45
416309	R84694	Hs. 79194	cAMP responsive element binding protein	6.20E−06	2.45
424090	X99699	Hs. 139262	XIAP associated factor-1	1.47E−06	2.44
448901	AK001021	Hs. 22505	hypothetical protein FLJ10159	1.09E−08	2.44
429635	AW968360	Hs. 14355	Homo sapiens cDNA FLJ13207 fis, clone NT	2.80E−03	2.44
422173	BE385828	Hs. 250619	phorbolin-like protein MDS019	2.07E−08	2.44
439708	AI761369	Hs. 59584	hypothetical protein FLJ21144	4.54E−05	2.43
449239	T24653	Hs. 23360	likely ortholog of yeast ARV1	1.44E−06	2.43
441327	AK001706	Hs. 7778	hypothetical protein FLJ10751	1.41E−07	2.43
407366	AF026942	Hs. 17518	gb: Homo sapiens cig33 mRNA, partial sequ	7.03E−06	2.43
412898	AI129903	Hs. 74669	vesicle-associated membrane protein 5 (m	1.35E−04	2.42
452355	N54926	Hs. 29202	G protein-coupled receptor 34	1.31E−05	2.42
446526	H89616		Homo sapiens cDNA FLJ13357 fis, clone PL	9.78E−04	2.42
421915	AW207000	Hs. 126857	Homo sapiens cDNA FLJ12936 fis, clone NT	7.84E−06	2.41
443486	NM_003428	Hs. 9450	zinc finger protein 84 (HPF2)	4.22E−03	2.40
457465	AW301344	Hs. 122908	DNA replication factor	1.19E−04	2.40
439718	AA307634	Hs. 6650	vacuolar protein sorting 45B (yeast homo	6.66E−08	2.40
440874	NM_003188	Hs. 7510	mitogen-activated protein kinase kinase	5.30E−05	2.40
420137	AA306478	Hs. 95327	CD3D antigen, delta polypeptide (TiT3 co	1.30E−05	2.40
429164	AI688663	Hs. 116586	ESTs	4.14E−04	2.40
427484	N32859	Hs. 37288	nuclear receptor subfamily 1, group D, m	1.58E−07	2.39
413815	AL046341	Hs. 75562	discoidin domain receptor family, member	5.22E−04	2.39
452835	AK001269	Hs. 30738	hypothetical protein FLJ10407	2.27E−09	2.39
414669	Z83850	Hs. 76838	serine (or cysteine) proteinase inhibito	2.67E−13	2.39
409154	U72882	Hs. 50842	interferon-induced protein 35	2.65E−09	2.39
420952	AA282067	Hs. 88972	ESTs, Moderately similar to A46010 X-lin	8.44E−04	2.39
416068	R45985	Hs. 115175	sterile-alpha motif and leucine zipper c	2.72E−03	2.38
450607	AL050373	Hs. 25213	hypothetical protein	2.15E−06	2.38
421040	AA715026	Hs. 135280	ESTs	1.18E−06	2.38
450206	AI796450	Hs. 201600	ESTs	4.49E−06	2.38
426805	AB032945	Hs. 172506	myosin VB	8.69E−05	2.37
436436	AI417516	Hs. 202091	ESTs	6.37E−04	2.37
428928	BE409838	Hs. 194657	cadherin 1, type 1, E-cadherin (epitheli	3.30E−07	2.37
414489	AI620677	Hs. 73105	ESTs	3.01E−08	2.37
443854	AI089079	Hs. 135214	hypothetical protein FLJ12800	3.53E−05	2.36
402424			NM_024901: Homo sapiens hypothetical prot	1.01E−05	2.36
451752	AB032997		KIAA1171 protein	1.18E−14	2.36
435458	F11872	Hs. 4892	Homo sapiens clone 24841 mRNA sequence	2.25E−03	2.36
428180	AI129767	Hs. 182874	guanine nucleotide binding protein (G pr	2.38E−05	2.35
448760	AA313825	Hs. 323583	AD036 protein	1.47E−07	2.35
425235	AA353113	Hs. 112497	Homo sapiens cDNA: FLJ22743 fis, clone H	2.65E−06	2.34
404649			Target Exon	1.06E−08	2.34
420174	AI824144	Hs. 199749	ESTs	5.79E−07	2.34
423258	L13460	Hs. 1644	cytochrome P450, subfamily VIIA (cholest	1.20E−05	2.34
444324	AI301330	Hs. 143838	ESTs	3.55E−05	2.33
414283	AW960011	Hs. 154993	ESTs	1.70E−07	2.33
412802	U41518	Hs. 74602	aquaporin 1 (channel-forming integral pr	5.06E−04	2.33
425375	AA631977	Hs. 155995	KIAA0643 protein	4.34E−05	2.33
428514	AW236861	Hs. 193139	ESTs	6.38E−09	2.32
423645	AI215632	Hs. 147487	ESTs	5.17E−06	2.32
448222	AI648587	Hs. 20725	Mov10 (Moloney teukemia virus 10, mouse)	7.56E−06	2.31
422633	X56832	Hs. 118804	enolase 3, (beta, muscle)	2.83E−09	2.31
429756	AB022663	Hs. 215857	ring finger protein 14	2.40E−07	2.31
428342	AI739168		Homo sapiens cDNA FLJ13458 fis, clone PL	5.59E−06	2.31
421246	AW582962	Hs. 102897	CGI-47 protein	1.36E−06	2.30
442821	BE391929	Hs. 8752	transmembrane protein 4	7.86E−06	2.30
410541	AA065003	Hs. 64179	syntenin-2 protein	2.03E−03	2.29
441872	BE567100	Hs. 154938	hypothetical protein MDS025	2.15E−09	2.29
423804	AW403448	Hs. 16725	interferon-stimulated transcription fact	3.25E−07	2.28
411049	AW814885	Hs. 19553	ESTs	6.16E−05	2.28
426272	AW450671	Hs. 189284	ESTs	6.41E−06	2.28
440975	AW499914	Hs. 7579	hypothetical protein FLJ10402	6.22E−07	2.28
447651	T60407	Hs. 217882	ESTs, Moderately similar to ALU1_HUMAN A	5.50E−08	2.28
410577	X91911	Hs. 64639	glioma pathogenesis-related protein	8.61E−07	2.27
433309	AA807060	Hs. 126558	ESTs	2.10E−03	2.26
447973	AB011169	Hs. 20141	similar to S. cerevisiae SSM4	1.75E−06	2.26
426437	BE076537	Hs. 169895	ubiquitin-conjugating enzyme E2L 6	1.56E−09	2.26
452744	AI267652	Hs. 246107	Homo sapiens mRNA; cDNA DKFZp434E082 (fr	4.59E−11	2.25
418452	BE379749	Hs. 85201	C-type (calcium dependent, carbohydrate-	4.78E−11	2.25
420245	AA256902	Hs. 252433	Homo sapiens cDNA FLJ13794 fis, clone TH	4.55E−05	2.24
431677	AK000496	Hs. 306989	hypothetical protein FLJ20489	2.67E−05	2.24
421902	BE392717		gb: 601307571F1 NIH_MGC_44 Homo sapiens c	1.28E−04	2.24
413869	NM_000878	Hs. 75596	interleukin 2 receptor, beta	2.47E−07	2.24
443787	AV646505	Hs. 122155	ESTs	5.12E−04	2.24
427581	NM_014788	Hs. 179703	KIAA0129 gene product	1.27E−10	2.23
416224	NM_002902	Hs. 79088	reticulocalbin 2, EF-hand calcium bindin	1.37E−07	2.23
405533			Target Exon	1.20E−04	2.23
402230			Fgenesh predicted: CYTOCHROME P450 4F5 (	2.46E−06	2.23
429857	AF089897	Hs. 294030	topoisomerase-related function protein 4	5.01E−06	2.21
437536	X91221	Hs. 144465	ESTs	1.55E−05	2.21
446094	AK001760	Hs. 13801	KIAA1685 protein	1.54E−07	2.20
444097	AW517412	Hs. 150757	ESTs	3.40E−03	2.20
425268	AI807883	Hs. 180059	Homo sapiens cDNA FLJ20653 fis, clone KA	3.58E−04	2.20
400751			NM_003105*: Homo sapiens sortilin-related	4.17E−04	2.20
424145	AW802763	Hs. 193124	pyruvate dehydrogenase kinase, isoenzyme	2.84E−06	2.19
430339	W28608	Hs. 239625	integral membrane protein 2B	2.63E−06	2.19
419287	X91906	Hs. 89872	chloride channel 5 (nephrolithiasis 2, X	1.23E−06	2.19
427374	AI150033	Hs. 143686	ESTs	8.34E−03	2.19
427043	AA397679		ESTs	2.93E−04	2.19
400694			Target Exon	5.84E−07	2.18
421014	NM_012227		Pseudoautosomal GTP-binding protein-like	6.96E−03	2.17
408078	N50928	Hs. 45203	ESTs	8.51E−04	2.17
447009	AB002340	Hs. 16950	KIAA0342 gene product	8.64E−07	2.17
422239	AI878922	Hs. 180139	SMT3 (suppressor of mif two 3. yeast) ho	6.16E−07	2.16
413786	AW613780	Hs. 13500	ESTs	6.01E−10	2.16
438307	AB011093	Hs. 6150	hypothetical protein MGC15913	1.91E−08	2.16
455187	AW864050		gb: PM2-SN0013-120400-003-c12 SN0013 Homo	1.69E−03	2.15
459487	AA699665		gb: zi78b05.s1 Soares_fetal_liver_spleen—	7.20E−04	2.15
449935	AA004798	Hs. 108311	ESTs, Weakly similar to T00351 hypotheti	9.75E−09	2.15
428695	AI355647	Hs. 189999	purinergic receptor (family A group 5)	1.45E−06	2.15
449964	AW001741	Hs. 24243	hypothetical protein FLJ10706	1.23E−04	2.14
427398	AW390020	Hs. 20415	chromosome 21 open reading frame 11	3.46E−04	2.14
440548	AL117408	Hs. 7274	DKFZP434P1750 protein	3.31E−03	2.14
440464	AI917706	Hs. 129997	ESTs	1.49E−05	2.14
422515	AW500470	Hs. 117950	multifunctional polypeptide similar to S	1.55E−05	2.14
451190	H38361	Hs. 26045	protein tyrosine phosphatase, receptor t	2.99E−05	2.13
422649	BE258692	Hs. 118910	tumor susceptibility gene 101	1.82E−06	2.13
435374	AI049889		ESTs	4.37E−04	2.13
423062	NM_003655	Hs. 5637	ESTs	8.76E−07	2.13
425164	R18189		gb: yf98f10.r1 Soares infant brain 1NIB H	4.67E−04	2.12
421685	AF189723	Hs. 106778	ATPase, Ca transporting, type 2C, member	6.05E−05	2.12
440266	AA088809	Hs. 19525	hypothetical protein FLJ22794	5.23E−06	2.12
443574	U83993	Hs. 321709	purinergic receptor P2X, ligand-gated io	7.69E−05	2.12
447735	AA775268	Hs. 6127	Homo sapiens cDNA: FLJ23020 fis, clone L	3.38E−04	2.11
433426	H69125	Hs. 133525	ESTs	1.40E−07	2.11
450056	BE047394	Hs. 8208	ESTs, Weakly similar to S71512 hypotheti	3.36E−04	2.11
418027	AB037807	Hs. 83293	hypothetical protein	1.30E−06	2.11
421650	AA781795	Hs. 122587	ESTs	2.45E−07	2.11
453909	AW004045	Hs. 203365	ESTs	2.51E−04	2.11
444847	AI199345	Hs. 153393	ESTs	1.43E−04	2.11
416448	L13210	Hs. 79339	lectin, galactoside-binding, soluble, 3	3.05E−11	2.10
449140	AW013840	Hs. 202092	ESTs	6.30E−05	2.10
430593	AA985190	Hs. 246875	hypothetical protein FLJ20059	5.90E−04	2.10
408791	AW272251	Hs. 254651	ESTs	1.02E−04	2.10
416435	AI431301		KIAA0129 gene product	4.53E−07	2.10
431637	AI879330	Hs. 265960	hypothetical protein FLJ10563	9.82E−04	2.10
442547	AA306997	Hs. 217484	ESTs, Weakly similar to ALU1_HUMAN ALU S	3.06E−04	2.10
419560	AA456130		KIAA1255 protein	7.10E−05	2.10
441673	AI018657		ESTs	1.80E−04	2.09
452827	AI571835	Hs. 55468	ESTs	9.60E−07	2.09
430341	NM_006348	Hs. 239631	golgi transport complex 1 (90 kDa subuni	2.32E−04	2.09
442160	AI337127	Hs. 156325	ESTs	6.80E−09	2.09
416754	H07145	Hs. 6799	ESTs, Weakly similar to T12483 hypotheti	1.55E−05	2.09
446731	BE378875	Hs. 16059	HSPC009 protein	1.50E−03	2.09
434128	W93170	Hs. 284164	protein x 0004	2.58E−06	2.08
426801	AA486846	Hs. 271795	ESTs, Weakly similar to I38022 hypotheti	4.92E−05	2.08
412556	AW961963		gb: EST374036 MAGE resequences, MAGG Homo	4.04E−03	2.08
401467			NM_022137*: Homo sapiens secreted modular	8.05E−03	2.08
416714	AF283770	Hs. 79630	CD79A antigen (immunoglobulin-associated	2.38E−03	2.08
441297	AW403084	Hs. 7766	ubiquitin-conjugating enzyme E2E 1 (homo	4.09E−05	2.08
449689	AF228421	Hs. 23889	DKFZP564A032 protein	1.72E−04	2.07
432360	BE045243	Hs. 274416	Target CAT	4.08E−07	2.07
424308	AW975531	Hs. 154443	minichromosome maintenance deficient (S.	2.18E−07	2.07
424618	L29472	Hs. 1802	major histocompatibility complex, class	3.53E−06	2.07
421261	AA600853	Hs. 98133	ESTs	1.01E−03	2.06
430200	BE613337	Hs. 234896	geminin	1.10E−11	2.06
423968	AF098277	Hs. 136529	solute carrier family 23 (nucleobase tra	1.34E−07	2.06
453313	BE005771	Hs. 153746	hypothetical protein FLJ22490	3.19E−03	2.06
403789			NM_001334*: Homo-sapiens cathepsin O (CTS	4.24E−05	2.06
427561	AI123333	Hs. 134191	ESTs	1.07E−08	2.06
454877	AW836463		gb: PM3-LT0032-231299-001-d01 LT0032 Homo	6.46E−07	2.06
408716	AI567839	Hs. 151714	Homo sapiens mRNA for KIAA1769 protein,	7.10E−07	2.06
438182	AW342140	Hs. 182545	ESTs, Weakly similar to ALU1_HUMAN ALU S	3.05E−05	2.05
441993	BE395143	Hs. 71523	ESTs, Weakly similar to S44243 endosomal	7.66E−04	2.05
427648	AI376722	Hs. 180062	proteasome (prosome, macropain) subunit,	6.20E−10	2.05
414646	AA353776	Hs. 901	CD48 antigen (B-cell membrane protein)	4.38E−07	2.05
458079	AI796870	Hs. 54277	DNA segment on chromosome X (unique) 992	1.32E−05	2.05
446783	AW138343	Hs. 141867	ESTs	3.84E−03	2.05
406117			C19001795: gi|10434258|dbj|BAB14191.1|(A	3.18E−06	2.05
453255	AA278167	Hs. 19215	Homo sapiens, clone IMAGE: 3605822, mRNA	3.20E−04	2.04
446619	AU076643	Hs. 313	secreted phosphoprotein 1 (osteopontin,	9.85E−03	2.04
437967	BE277414	Hs. 5947	mel transforming oncogene (derived from	1.65E−04	2.04
400137			Eos Control	1.05E−07	2.04
417787	R14948	Hs. 23883	ESTs	9.00E−07	2.04
417600	R01279	Hs. 16179	hypothetical protein FLJ23467	8.47E−03	2.04
411562	AL050201	Hs. 70769	hypothetical protein DKFZp586E1923	1.33E−06	2.04
418733	AA227714		KIAA0129 gene product	1.31E−09	2.03
412651	AA115333	Hs. 107968	ESTs	6.35E−09	2.03
406420			C19000229*: gi|6753826|ref|NP_034311.1|f	1.99E−03	2.03
423397	NM_001838	Hs. 1652	chemokine (C-C motif) receptor 7	4.05E−05	2.03
447002	BE242866	Hs. 16933	HepA-related protein	1.96E−06	2.03
409038	T97490	Hs. 50002	small inducible cytokine subfamily A (Cy	4.88E−04	2.03
419737	H24185	Hs. 92918	hypothetical protein	2.46E−04	2.03
436235	AI084982	Hs. 120790	ESTs	4.48E−05	2.03
447043	BE410773	Hs. 115412	hypothetical protein FLJ13881	3.32E−06	2.02
411987	AA375975	Hs. 24831	ESTs, Moderately similar to ALU8_HUMAN A	5.80E−04	2.02
400245			Eos Control	1.28E−06	2.02
447906	AL050062	Hs. 19999	DKFZP566K023 protein	5.25E−05	2.02
451820	AW058357	Hs. 199248	ESTs	2.88E−05	2.02
418216	AA662240	Hs. 283099	AF15q14 protein	5.20E−10	2.02
408949	AF189011	Hs. 49163	putative ribonuclease III	2.94E−05	2.01
423962	R73257	Hs. 42586	KIAA1560 protein	2.03E−04	2.01
432053	AI024572		ESTs	8.07E−08	2.01
412754	AW160375	Hs. 74565	amyloid beta (A4) precursor-like protein	1.10E−03	2.01
453927	AA082465	Hs. 125031	choline/ethanolaminephosphotransferase	6.17E−08	2.01
430556	AW967807	Hs. 13797	ESTs	3.75E−04	2.01
451494	AI799444	Hs. 247095	ESTs, Moderately similar to ALU7_HUMAN A	9.08E−04	2.00
422546	AB007969	Hs. 301478	KIAA0500 protein	1.62E−06	2.00
424755	AB033094	Hs. 152925	KIAA1268 protein	5.02E−08	2.00
406782	AA430373		gb: zw20f11.s1 Soares ovary tumor NbHOT H	2.29E−03	1.99
427128	AW301984	Hs. 49349	hypothetical protein FLJ12619	1.86E−07	1.99
414159	AW511414	Hs. 257352	apolipoprotein L, 6	5.86E−12	1.99
418348	AI537167	Hs. 96322	hypothetical protein FLJ23560	6.15E−04	1.99
410369	AW975159	Hs. 293097	ESTs, Weakly similar to A55380 faciogeni	5.39E−05	1.99
410315	AI638871	Hs. 152519	Homo sapiens cDNA: FLJ22524 fis, clone H	4.48E−07	1.99
407644	D16815		nuclear receptor subfamily 1, group D, m	1.10E−05	1.98
459107	AA811881	Hs. 28505	ubiquitin-conjugating enzyme E2H (homolo	1.49E−03	1.98
433150	AB035274	Hs. 21320	postreplication repair protein hRAD18p	8.38E−04	1.98
413823	AI341417	Hs. 29406	ESTs	9.53E−08	1.97
409518	BE384836	Hs. 3454	KIAA1821 protein	2.52E−04	1.97
439225	AA192669	Hs. 45032	ESTs	1.00E−06	1.97
430619	AF129756	Hs. 247452	HLA-B associated transcript-5	1.86E−06	1.97
432606	NM_002104	Hs. 3066	granzyme K (serine protease, granzyme 3;	1.05E−06	1.97
441298	AW136267	Hs. 166629	ESTs	6.99E−03	1.96
450931	N25156	Hs. 25648	tumor necrosis factor receptor superfami	4.52E−08	1.96
457234	AW968360	Hs. 14355	Homo sapiens cDNA FLJ13207 fis, clone NT	1.08E−04	1.96
442328	AI952430	Hs. 150614	ESTs, Weakly similar to ALU4_HUMAN ALU S	1.07E−04	1.96
414493	AL133921	Hs. 76272	retinoblastoma-binding protein 2	1.41E−07	1.96
427209	H06509	Hs. 92423	KIAA1566 protein	1.67E−06	1.96
416430	H60487	Hs. 159440	bile acid Coenzyme A: amino acid N-acylt	1.43E−05	1.96
448692	AW013907	Hs. 167531	methylcrotonoyl-Coenzyme A carboxylase 2	2.14E−03	1.95
418707	U97502	Hs. 87497	butyrophilin, subfamily 3, member A2	2.72E−11	1.95
440256	U23841	Hs. 18851	hypothetical protein FLJ10875	5.24E−06	1.95
436578	AI091435	Hs. 134859	ESTs	1.08E−06	1.94
423597	AL043117	Hs. 129872	sperm associated antigen 9	2.72E−04	1.94
446669	AW972832	Hs. 29468	ESTs	1.10E−04	1.93
436061	AI248584	Hs. 190745	Homo sapiens cDNA: FLJ21326 fis, clone C	3.75E−03	1.93
408291	AB023191	Hs. 44131	KIAA0974 protein	4.99E−05	1.93
432485	N90866	Hs. 276770	CDW52 antigen (CAMPATH-1 antigen)	5.39E−07	1.93
420653	AI224532	Hs. 88550	ESTs	6.18E−03	1.93
418504	BE159718	Hs. 85335	Homo sapiens mRNA; cDNA DKFZp564D1462 (f	1.63E−06	1.93
444398	AI146775	Hs. 143550	ESTs	7.61E−03	1.93
408731	R85652		Homo sapiens mRNA; cDNA DKFZp434F1928 (f	3.52E−04	1.93
436395	AJ227900		gb: Homo sapiens partial mRNA; ID EE2-16B	4.64E−08	1.92
429276	AF056085	Hs. 198612	G protein-coupled receptor 51	8.50E−05	1.92
426476	NM_003296	Hs. 2042	testis specific protein 1 (probe H4-1 p3	1.20E−03	1.92
454075	R43826	Hs. 16313	Kruppel-like zinc finger protein GLIS2	7.10E−03	1.92
445245	AB032973	Hs. 12461	LCHN protein	2.74E−10	1.91
457665	BE551196	Hs. 114275	ESTs	5.71E−03	1.91
418090	U57059	Hs. 83429	tumor necrosis factor (ligand) superfami	1.34E−09	1.91
427675	AW138190	Hs. 180248	zinc finger protein 124 (HZF-16)	3.00E−06	1.91
435745	AW967059		Homo sapiens clone 24711 mRNA sequence	5.05E−04	1.91
429798	AL117578	Hs. 222909	DKFZP434C128 protein	5.79E−09	1.91
424637	NM_015057	Hs. 151411	KIAA0916 protein	7.41E−07	1.91
445447	H14522		ribosomal protein S4, X-linked	4.52E−05	1.91
428372	AK000684	Hs. 183887	hypothetical protein FLJ22104	4.09E−08	1.90
444454	BE018316	Hs. 11183	sorting nexin 2	1.42E−06	1.90
431122	AI267593	Hs. 250535	Homo sapiens mRNA; cDNA DKFZp434N2412 (f	2.54E−04	1.90
436318	T77359	Hs. 14040	Homo sapiens cDNA: FLJ21772 fis, clone C	4.82E−04	1.90
446553	AB021179	Hs. 15299	HMBA-inducible	6.90E−08	1.90
433401	AF039698	Hs. 284217	serologically defined colon cancer antig	6.31E−08	1.89
421677	H64092	Hs. 38282	ESTs	2.70E−08	1.89
424194	BE245833	Hs. 169854	gb: TCBAP1E1908 Pedialric pre-B cell acut	2.67E−03	1.89
426990	AL044315	Hs. 173094	Homo sapiens mRNA for KIAA1750 protein.	2.18E−04	1.89
439810	AL109710	Hs. 85568	EST	1.53E−03	1.89
414757	U46922	Hs. 77252	fragile histidine triad gene	6.95E−06	1.89
430587	AK000341	Hs. 246107	elongation of very long chain fatty acid	1.22E−05	1.88
440527	AV657117	Hs. 184164	ESTs, Moderately similar to S65657 alpha	2.16E−06	1.88
414405	AI362533		KIAA0306 protein	1.88E−06	1.88
414171	AA360328	Hs. 865	RAP1 A, member of RAS oncogene family	1.72E−04	1.88
448198	BE622100	Hs. 209406	ESTs, Weakly similar to I38600 zinc fing	7.63E−07	1.88
433017	Y15067	Hs. 279914	zinc finger protein 232	1.66E−06	1.88
449609	BE246434	Hs. 289026	guanine nucleotide binding protein (G pr	4.83E−05	1.88
427600	AW630918	Hs. 179774	proteasome (prosome, macropain) activato	1.19E−06	1.88
409362	AC008044	Hs. 54418	alkylation repair; alkB homolog	6.66E−03	1.88
450379	T77813	Hs. 268590	ESTs	4.05E−04	1.87
404426			C8000068*: gi|5453579|ref|NP_006120.1| bo	1.01E−08	1.87
407949	W21874	Hs. 247057	ESTs, Weakly similar to 2109260A B cell	9.97E−06	1.87
446570	AV659177	Hs. 127160	ESTs	4.44E−07	1.87
409896	AW205479	Hs. 279780	NY-REN-18 antigen	2.36E−08	1.87
419867	NM_014246	Hs. 252387	cadherin, EGF LAG seven-pass G-type rece	3.90E−04	1.87
447178	AW594641	Hs. 192417	ESTs	5.76E−07	1.87
438475	W03856	Hs. 13188	ESTs, Highly similar to Gene product wit	6.54E−09	1.87
443492	AI073989	Hs. 144913	hypothetical protein FLJ23514	3.68E−04	1.87
400303	AA242758	Hs. 79136	LIV-1 protein, estrogen regulated	1.02E−09	1.87
417052	NM_000712	Hs. 81029	biliverdin reductase A	1.44E−08	1.87
452406	AI002968	Hs. 235402	ESTs, Weakly similar to T26525 hypotheti	5.04E−08	1.86
432857	NM_016103	Hs. 279582	GTP-binding protein Sara	4.59E−07	1.86
428933	AA743433	Hs. 119292	ESTs	1.97E−04	1.86
429360	AK000658	Hs. 200332	hypothetical protein FLJ20651	2.52E−06	1.86
422352	AA766296	Hs. 99200	ESTs	6.40E−05	1.86
438449	AK001333	Hs. 6216	Homo sapiens hepatocellular carcinoma-as	5.96E−04	1.86
421524	AA312082	Hs. 105445	GDNF family receptor alpha 1	5.48E−08	1.86
419598	AW410557	Hs. 91471	ATPase, Class II, type 9B	1.54E−03	1.86
445317	AI219856		ESTs	2.25E−04	1.86
401274			Target Exon	9.48E−05	1.86
433028	AI199144	Hs. 283737	AD-017 protein	2.06E−05	1.86
419439	BE252908		thyroglobulin	2.28E−06	1.86
453037	AA045175	Hs. 17914	ESTs	8.76E−07	1.86
432468	AW402155	Hs. 3003	CD3E antigen, epsilon polypeptide (TiT3	2.04E−03	1.86
450997	AW580830	Hs. 35254	hypothetical protein FLB6421	8.02E−10	1.86
441787	AA813278	Hs. 9788	hypothetical protein MGC10924 similar to	1.19E−06	1.86
450381	AW291767	Hs. 189829	hypothetical protein FLJ12765	1.37E−03	1.86
410199	AW377424	Hs. 205126	Homo sapiens cDNA: FLJ22667 fis, clone H	2.36E−08	1.86
423215	C16770		gb: C16770 Clontech human aorta polyA mRN	8.56E−03	1.85
422085	AB018257	Hs. 288773	zinc finger protein 294	1.80E−04	1.85
429358	AB037825	Hs. 200317	KIAA1404 protein	1.28E−08	1.85
447631	AW140016	Hs. 161415	ESTs	4.33E−06	1.85
453954	AW118336	Hs. 75251	DEAD/H (Asp-Glu-Ala-Asp/His) box binding	6.32E−04	1.85
438050	BE262816	Hs. 6061	protein kinase, AMP-activated, beta 1 no	6.39E−04	1.85
425939	AK001527	Hs. 163953	hypothetical protein FLJ10665	2.37E−03	1.85
426911	AA812691	Hs. 278985	ESTs	1.44E−04	1.85
426126	AL118747	Hs. 26691	ESTs	7.85E−05	1.85
400929			ENSP00000252232*: Sterol regulatory eleme	1.42E−03	1.85
413048	M93221	Hs. 75182	mannose receptor, C type 1	6.72E−07	1.85
420613	AI873871	Hs. 7041	ESTs, Weakly similar to A47582 B-cell gr	5.30E−09	1.85
409533	AW969543	Hs. 21291	mitogen-activated protein kinase kinase	2.39E−04	1.85
430024	AI808780	Hs. 227730	integrin, alpha 6	5.50E−07	1.85
407110	AA018042	Hs. 252085	Prader-Willi/Angelman syndrome-5	1.23E−05	1.85
403790			NM_001334*: Homo sapiens cathepsin O (CTS	1.67E−05	1.84
408214	AL120445	Hs. 77823	hypothetical protein FLJ21343	9.69E−06	1.84
443285	AI301918	Hs. 334264	ESTs	7.83E−04	1.84
445615	AW449905	Hs. 40919	Homo sapiens cDNA FLJ14511 fis. clone NT	321E−04	1.84
449720	AA311152	Hs. 288708	hypothetical protein FLJ21562	4.25E−06	1.84
445806	AL137516	Hs. 13323	hypothetical protein FLJ22059	1.57E−04	1.84
457400	AF032906	Hs. 252549	cathepsin Z	1.05E−07	1.84
424571	BE379766		polymerase (RNA) II (DNA directed) polyp	1.04E−10	1.84
408328	R93852	Hs. 28411	ESTs	5.70E−04	1.84
436363	AA843926	Hs. 124434	ESTs	6.44E−05	1.84
418850	AJ242977	Hs. 89278	hypothetical protein FLJ11186	4.88E−09	1.83
422711	D60641		Homo sapiens mRNA; cDNA DKFZp586l1518 (f	3.71E−05	1.83
444889	AI917770		ESTs	6.36E−05	1.83
446506	AI123118	Hs. 15159	chemokine-like factor, alternatively spl	3.56E−11	1.83
424437	BE244700	Hs. 147049	cut (Drosophila)-like 1 (CCAAT displacem	1.49E−04	1.83
422371	NM_001882	Hs. 115617	corticotropin releasing hormone-binding	2.26E−07	1.83
419461	AI452601	Hs. 288869	nuclear receptor subfamily 2, group F, m	5.42E−09	1.83
434629	AA789081	Hs. 4029	glioma-amplified sequence-41	1.80E−05	1.83
425367	BE271188	Hs. 155975	protein tyrosine phosphatase, receptor t	1.53E−05	1.82
453275	AW247236	Hs. 32826	CGI-130 protein	1.86E−07	1.82
418751	BE389014		phosphoinositide-3-kinase, regulatory su	1.59E−07	1.82
445525	BE149866	Hs. 14831	Homo sapiens, Similar to zinc linger pro	5.85E−07	1.82
432107	AA779945	Hs. 303294	ESTs, Weakly similar to ALUB_HUMAN !!!!	3.18E−03	1.82
407355	AA846203	Hs. 193974	ESTs, Weakly similar to ALU1_HUMAN ALU S	5.23E−04	1.82
422646	H87863	Hs. 151380	ESTs, Weakly similar to T16584 hypotheti	1.30E−04	1.82
414485	W27026	Hs. 182625	VAMP (vesicle-associated membrane protei	4.19E−03	1.82
421931	NM_000814	Hs. 1440	gamma-aminobutyric acid (GABA) A recepto	9.00E−05	1.82
454056	AI368836	Hs. 24808	ESTs, Weakly similar to I38022 hypotheti	2.84E−04	1.82
459067	AW207623	Hs. 262716	ESTs, Moderately similar to S65657 alpha	1.04E−03	1.81
422530	AW972300	Hs. 118110	bone marrow stromal cell antigen 2	5.31E−11	1.81
432051	AF112461	Hs. 272383	G protein-coupled receptor 57	2.98E−03	1.81
405268			ENSP00000223174*: KIAA0783 PROTEIN.	7.25E−05	1.81
419951	AI653415	Hs. 195789	ESTs	3.51E−06	1.81
457259	AA459713	Hs. 36475	KIAA0493 protein	1.47E−04	1.81
441683	BE564214	Hs. 102946	ESTs	4.30E−07	1.81
421263	AB020638	Hs. 103000	KIAA0831 protein	4.10E−08	1.80
431696	AA259068	Hs. 267819	protein phosphatase 1, regulatory (inhib	2.00E−03	1.80
437143	AW204056	Hs. 8917	ESTs	2.07E−09	1.80
450728	AW162923	Hs. 25363	presenilin 2 (Alzheimer disease 4)	5.41E−05	1.80
417312	AW888411	Hs. 250811	leukemia-associated phosphoprotein p18 (	3.81E−06	1.80
432647	AI807481	Hs. 278581	fibroblast growth factor receptor 2 (bac	8.16E−07	1.80
424232	AB015982	Hs. 143460	protein kinase C, nu	1.49E−04	1.80
412715	NM_000947	Hs. 74519	primase, polypeptide 2A (58 kD)	8.01E−05	1.80
450260	AW090384	Hs. 7739	hypothetical protein MGC12904	1.06E−04	1.80
424862	AB011472	Hs. 153546	CDC23 (cell division cycle 23, yeast, ho	9.20E−08	1.80
430060	NM_002941	Hs. 301198	roundabout (axon guidance receptor, Dros	4.39E−03	1.80
420338	AA825595	Hs. 88269	Homo sapiens, clone MGC: 17339, mRNA, com	8.17E−07	1.80
402855			NM_001839*: Homo sapiens calponin 3, acid	8.44E−04	1.80
430043	AI040009	Hs. 306327	Homo sapiens mRNA; cDNA DKFZp434A012 (fr	4.12E−07	1.79
438122	AI620270	Hs. 129837	ESTs, Weakly similar to Z263_HUMAN ZINC	1.45E−03	1.79
432460	H12912	Hs. 274691	adenylate kinase 3	4.12E−10	1.79
445523	Z30118	Hs. 293788	ESTs, Moderately similar to unnamed prot	7.17E−05	1.79
406765	AA609132	Hs. 76662	hypothetical protein MGC2993	9.48E−08	1.79
400517			lengsin	4.89E−07	1.79
421804	AF032105	Hs. 108447	spinocerebellar ataxia 7 (olivopontocere	2.48E−05	1.79
424653	AW977534	Hs. 151469	calcium/calmodulin-dependent serine prot	8.73E−04	1.79
418240	BE019261	Hs. 83869	hypothetical protein	1.76E−05	1.79
458196	AI802408		ubiquitin A-52 residue ribosomal protein	1.02E−03	1.79
433528	AK001605	Hs. 3376	hypothetical protein FLJ10743	2.88E−05	1.79
402976			Target Exon	3.60E−04	1.78
433730	AK002135	Hs. 3542	hypothetical protein FLJ11273	6.69E−06	1.78
446874	AW968304	Hs. 56156	ESTs	1.09E−05	1.78
436856	AI469355	Hs. 127310	ESTs	5.43E−09	1.78
459724	AI732889	Hs. 47341	ESTs, Weakly similar to alternatively sp	2.77E−03	1.78
433707	AI791584	Hs. 130741	ESTs	3.51E−03	1.78
449523	NM_000579	Hs. 54443	chemokine (C-C motif) receptor 5	3.38E−06	1.78
453250	AI346520	Hs. 121619	chromosome 11 open reading frame 15	2.30E−08	1.77
430718	AI792814		Homo sapiens BAC clone RP11-335J18 from	8.53E−04	1.77
452065	AK000360	Hs. 27721	Wolf-Hirschhorn syndrome candidate 1-lik	8.41E−04	1.77
426899	AL043221	Hs. 172825	KIAA1037 protein	9.25E−07	1.77
441791	AW372449	Hs. 61271	hypothetical protein FLJ21159	1.05E−04	1.77
413029	AL119399	Hs. 293850	ESTs	7.99E−05	1.76
453319	AI985369	Hs. 301134	ESTs	1.19E−03	1.76
457425	AW139202	Hs. 301209	myeloid/lymphoid or mixed-lineage leukem	5.83E−05	1.76
445786	AW629819	Hs. 144502	hypothetical protein FLJ22055	3.11E−06	1.76
419175	AW270037		KIAA0779 protein	7.55E−08	1.76
428291	AA534009	Hs. 183487	interferon stimulated gene (20 kD)	9.79E−06	1.76
408405	AK001332	Hs. 44672	hypothetical protein FLJ10470	2.98E−11	1.76
426310	NM_000909	Hs. 169266	neuropeptide Y receptor Y1	1.50E−03	1.75
414812	X72755	Hs. 77367	monokine induced by gamma interferon	5.22E−06	1.75
453020	AL162039	Hs. 31422	Homo sapiens mRNA; cDNA DKFZp434M229 (fr	2.69E−04	1.75
403743			C1002604: gi|8393668|ref|NP_058989.1| kin	1.47E−04	1.75
433675	AW977653	Hs. 75319	ribonucleotide reductase M2 polypeptide	7.35E−05	1.75
410691	AW239226	Hs. 65450	reticulon 4	3.22E−06	1.75
421443	BE550141	Hs. 156148	hypothetical protein FLJ13231	9.38E−05	1.74
414183	AW957446	Hs. 301711	ESTs	1.83E−04	1.74
427221	L15409	Hs. 174007	von Hippel-Lindau syndrome	3.24E−04	1.74
443589	H52931	Hs. 165067	ESTs	3.32E−05	1.74
449480	AI741617	Hs. 108447	spinocerebellar ataxia 7 (olivopontocere	1.75E−05	1.74
442272	AA988302	Hs. 129172	ESTs	2.85E−03	1.74
429747	M87507	Hs. 2490	caspase 1, apoptosis-related cysteine pr	2.73E−07	1.74
414261	BE267466	Hs. 13561	hypothetical protein MGC4692	9.05E−03	1.74
442138	AA445973	Hs. 13303	Homo sapiens cDNA: FLJ21784 fis, clone H	3.64E−05	1.74
412584	X54870	Hs. 74085	DNA segment on chromosome 12 (unique) 24	1.90E−06	1.74
406825	AI982529	Hs. 84298	CD74 antigen (invariant polypeptide of m	9.75E−06	1.73
421893	NM_001078	Hs. 109225	vascular cell adhesion molecule 1	6.57E−07	1.73
432094	AI658580	Hs. 61426	Homo sapiens mesenchymal stem cell prote	7.20E−07	1.73
420344	BE463721	Hs. 97101	putative G protein-coupled receptor	9.18E−04	1.73
431740	N75450	Hs. 183412	ESTs, Moderately similar to AF116721 67	4.00E−04	1.73
419652	AL157485	Hs. 91973	hypothetical protein	1.88E−04	1.73
453173	AB007902	Hs. 32168	KIAA0442 protein	6.67E−07	1.72
407690	R47799	Hs. 266957	hypothetical protein FLJ14281	4.68E−08	1.72
426817	AL122088	Hs172627	Homo sapiens mRNA; cDNA DKFZp564C0671 (f	4.70E−08	1.72
418945	BE246762	Hs. 89499	arachidonate 5-lipoxygenase	2.44E−04	1.72
403828			C4000447*: gi|7705570|ref|NP_038851.1| KI	1.13E−04	1.72
427920	Z11502	Hs. 181107	annexin A13	7.84E−04	1.72
421394	S49953	Hs. 103989	DNA-binding transcriptional activator	1.79E−03	1.72
447513	AW955776	Hs. 313500	ESTs, Moderately similar to ALU7_HUMAN A	3.04E−08	1.71
405689			NM_018850*: Homo sapiens ATP-binding cass	2.61E−04	1.71
441879	AI521936	Hs. 107149	novel protein similar to archaeal, yeast	4.46E−06	1.71
414781	D50917	Hs. 77293	KIAA0127 gene product	3.90E−05	1.71
444619	BE538082	Hs. 8172	ESTs, Moderately similar to A46010 X-lin	4.33E−04	1.71
451334	AI122691	Hs. 13268	ESTs	2.68E−05	1.71
446436	BE392690		activating transcription factor 5	4.25E−08	1.71
423332	AI091466	Hs. 127241	sorting nexin 7	7.16E−08	1.71
431660	T30267	Hs. 267120	hypothetical protein DKFZp434O1427	1.48E−04	1.70
425274	BE281191	Hs. 155462	minichromosome maintenance deficient (mi	4.90E−09	1.70
442961	BE614474		F-box only protein 22	4.42E−08	1.70
425995	M92432	Hs. 1974	guanylate cyclase 2D, membrane (retina-s	1.35E−03	1.70
429937	AL080155	Hs. 226372	DKFZP434J154 protein	1.69E−06	1.70
410660	AI061118	Hs. 65328	Fanconi anemia, complementation group F	3.51E−04	1.70
444866	BE620779	Hs. 12094	mitochondrial ribosomal protein L30	8.52E−05	1.70
416602	NM_006159	Hs. 79389	Protein kinase C-binding protein NELL2	5.82E−05	1.70
431263	AW129203	Hs. 322915	ESTs	2.31E−03	1.69
423201	NM_000163	Hs. 125180	growth hormone receptor	1.38E−05	1.69
430844	T94960		gb: ye38d07.r1 Stratagene lung (937210) H	8.59E−05	1.69
403742			Target Exon	9.17E−06	1.69
433001	AF217513	Hs. 279905	clone HQ0310 PRO0310p1	1.05E−05	1.69
426214	H59846	Hs. 321127	ESTs, Moderately similar to ALU7_HUMAN A	7.93E−03	1.69
430007	NM_014892	Hs. 227602	KIAA1116 protein	9.67E−06	1.69
429689	R77698	Hs. 337778	ESTs	4.90E−04	1.69
424626	AA344308	Hs. 128427	Homo sapiens BAC clone RP11-335J18 from	1.61E−04	1.69
410678	BE540516	Hs. 293732	hypothetical protein MGC3195	1.88E−05	1.69
439645	BE091801	Hs. 27167	ESTs, Weakly similar to I38022 hypotheti	7.02E−09	1.69
431530	X61615	Hs. 2798	leukemia inhibitory factor receptor	7.86E−05	1.69
434995	AW974995		gb: EST387100 MAGE resequences, MAGN Homo	2.70E−04	1.69
423420	AI571364	Hs. 128382	Homo sapiens mRNA; cDNA DKFZp761l1224 (f	3.52E−05	1.69
453210	AL133161	Hs. 32360	hypothetical protein FLJ10867	1.57E−05	1.69
446096	AI276454		gb: ql71a12.x1 Soares_NhHMPu_S1 Homosapi	3.79E−04	1.69
433546	AI075877	Hs. 125461	hypothetical protein FLJ11539	1.21E−03	1.68
435496	AW840171	Hs. 265398	PAR-6 beta	6.80E−05	1.68
447211	AL161961	Hs. 17767	KIAA1554 protein	1.96E−11	1.68
438277	AL022326	Hs. 6139	synaptogyrin 1	4.42E−03	1.68
403319			fms-related tyrosine kinase 3	4.52E−05	1.68
436332	AL049679	Hs. 82302	Homo sapiens cDNA FLJ14814 fis, clone NT	2.08E−05	1.68
434669	AF151534	Hs. 92023	core histone macroH2A2.2	3.36E−07	1.68
428123	AI702275	Hs. 104842	hypothetical protein FLJ23407	6.64E−05	1.68
436957	AA902488	Hs. 122952	ESTs	1.38E−05	1.68
421777	BE562088	Hs. 108196	HSPC037 protein	6.55E−04	1.68
437708	AB033020	Hs. 5801	KIAA1194 protein	8.24E−07	1.68
444821	AA053564	Hs. 12040	STE20-like kinase	1.25E−05	1.68
400170			Eos Control	3.70E−04	1.68
450221	AA328102	Hs. 24641	cytoskeleton associated protein 2	9.27E−06	1.68
448440	AA173467	Hs. 62402	p21/Cdc42/Rac1-activated kinase 1 (yeast	1.29E−06	1.68
424354	NM_014314	Hs. 145612	RNA helicase	2.12E−03	1.68
407369	AA989060	Hs. 193989	TAR DNA binding protein	4.61E−07	1.68
423054	AW449073	Hs. 278346	CDC2-related protein kinase 7	6.94E−08	1.67
443542	AI927065	Hs. 146040	ESTs	3.92E−05	1.67
452696	AI826645	Hs. 211534	ESTs	8.04E−06	1.67
438378	AW970529	Hs. 86434	hypothetical protein FLJ21816	2.17E−07	1.67
446552	AW470827	Hs. 156241	ESTs	2.20E−06	1.67
417707	AL035786	Hs. 82425	actin related protein 2/3 complex, subun	1.18E−07	1.67
442993	BE018682	Hs. 166196	ATPase, Class I, type 88, member 1	2.23E−07	1.67
430048	T65054	Hs. 73605	ESTs	3.31E−03	1.67
451050	AW937420		ESTs	5.05E−04	1.67
404602			C9001493*: gi|12735190|ref|XP_005622.2| t	1.97E−05	1.66
423882	BE387203	Hs. 134406	hypothetical protein FLJ20511	2.36E−03	1.66
421508	NM_004833	Hs. 105115	absent in melanoma 2	6.80E−05	1.66
419131	AA406293	Hs. 109526	ESTs	8.36E−06	1.66
452207	NM_014517	Hs. 28423	upstream binding protein 1 (LBP-1a)	1.14E−06	1.66
445411	AL137255	Hs. 12646	hypothetical protein FLJ22693	2.80E−08	1.66
403654			NM_003071: Homo sapiens SWI/SNF related,	1.90E−04	1.66
423450	AJ290445	Hs. 128759	KIAA0524 protein	1.00E−03	1.66
430315	NM_004293	Hs. 239147	guanine deaminase	2.69E−05	1.66
443547	AW271273		hypothetical protein FLJ12666	2.60E−10	1.66
417758	U27699	Hs. 82535	solute carrier family 6 (neurotransmitte	8.60E−07	1.66
417689	AA828347	Hs. 90998	KIAA0128 protein; septin 2	3.65E−09	1.66
449901	AI674072		gb: wd15h01.x1 Soares_NFL_T_GBC_S1 Homos	8.34E−07	1.66
425905	AB032959	Hs. 318584	novel C3HC4 type Zinc finger (ring finge	1.11E−03	1.66
407976	AI633875	Hs. 77823	hypothetical protein FLJ21343	2.07E−05	1.65
416276	U41060	Hs. 79136	LIV-1 protein, estrogen regulated	1.29E−05	1.65
418419	X55039	Hs. 85004	centromere protein B (80 kD)	1.89E−09	1.65
438384	W22358	Hs. 109778	KIAA1449 protein	9.10E−08	1.65
443065	H29584	Hs. 288198	hypothetical protein FLJ13949	3.07E−06	1.65
438527	AI969251	Hs. 115325	RAB7, member RAS oncogene family-like 1	2.96E−04	1.65
427507	AF240467	Hs. 179152	toll-like receptor 7	5.62E−03	1.65
439980	AL039706	Hs. 19414	ESTs, Weakly similar to S25150 gene p27	7.11E−05	1.64
419493	AF001212	Hs. 90744	proteasome (prosome, macropain) 26S subu	1.48E−04	1.64
437325	AF142481	Hs. 5548	f-box and leucine-rich repeat protein 5	9.02E−08	1.64
435525	AI831297	Hs. 123310	ESTs	2.20E−03	1.64
430515	AA746503	Hs. 283313	ESTs	6.68E−05	1.64
410165	BE560228	Hs. 71869	apoptosis-associated speck-like protein	1.09E−06	1.64
425996	W67330		hypothetical protein AL110115	6.40E−08	1.64
444665	BE613126	Hs. 47783	B aggressive lymphoma gene	7.26E−08	1.64
424960	BE245380	Hs. 153952	5′ nucleotidase (CD73)	2.14E−04	1.64
449722	BE280074	Hs. 23960	cyclin B1	2.23E−05	1.64
435427	AA682573	Hs. 188982	ESTs, Weakly similar to organic anion tr	4.66E−04	1.64
437186	AA338305	Hs. 5472	hypothetical protein FLJ20173	1.90E−04	1.64
448797	BE614460		ribosomal protein L17	6.90E−06	1.64
446684	AI910777	Hs. 125087	ESTs	2.60E−03	1.63
428413	AI984187	Hs. 245798	ESTs	4.04E−04	1.63
435787	AW162767	Hs. 100914	hypothetical protein FLJ10352	3.26E−05	1.63
448377	AI494514	Hs. 21264	ESTs	5.24E−04	1.63
451684	AF216751	Hs. 26813	CDA14	1.14E−03	1.63
402396			Target Exon	2.00E−04	1.63
441969	AI733386		ESTs, Weakly similar to ALU1_HUMAN ALU S	1.84E−04	1.63
421138	AA687420	Hs. 190145	ESTs	1.54E−05	1.63
417353	AA375752	Hs. 348140	Homo sapiens mRNA; cDNA DKFZp586F1822 (f	5.38E−04	1.63
410261	AF145713	Hs. 61490	schwannomin-interacting protein 1	3.36E−04	1.63
458476	AA336878	Hs. 9842	Human DNA sequence from clone RP4-788L20	4.80E−05	1.63
405372			NM_006841: Homo sapiens transporter prote	2.82E−04	1.63
452059	AI222069	Hs. 13015	hypothetical protein similar to mouse Dn	1.82E−05	1.63
410568	AW162948	Hs. 64542	cleavage and polyadenylation specific fa	1.28E−04	1.63
407502	U52096		gb: Human zinc finger protein (kr-znf1) m	2.30E−04	1.63
420560	AW207748	Hs. 59115	ESTs	4.40E−05	1.63
412530	AA766268	Hs. 266273	hypothetical protein FLJ13346	2.49E−06	1.63
448888	AW196663	Hs. 200242	caspase recruitment domain protein 6	2.43E−05	1.62
428220	BE183533	Hs. 347128	Human DNA sequence from clone 34B21 on c	1.64E−07	1.62
450621	AW297288	Hs. 55918	hypothetical protein FLJ11354	2.40E−06	1.62
419437	U61262	Hs. 90408	neogenin (chicken) homolog 1	7.24E−05	1.62
403694			Target Exon	8.29E−06	1.62
441253	AI632744	Hs. 129501	ESTs	4.42E−03	1.62
457770	BE065030	Hs. 124179	ESTs	7.93E−04	1.62
416647	BE297139	Hs. 79411	replication protein A2 (32 kD)	1.54E−06	1.62
410408	NM_012260	Hs. 63290	2-hydroxyphytanoyl-CoA lyase	3.56E−05	1.62
430248	AW958965	Hs. 236774	high-mobility group (nonhistone chromoso	1.57E−09	1.62
447547	NM_007229	Hs. 18842	protein kinase C and casein kinase subst	3.40E−06	1.61
431863	AA188185	Hs. 289043	spindlin	1.87E−08	1.61
430422	AI078115	Hs. 54680	ESTs	1.05E−06	1.61
445657	AW612141	Hs. 279575	Homo sapiens G-protein coupled receptor	1.89E−05	1.61
456740	AF068302	Hs. 125031	choline/ethanolaminephosphotransferase	2.48E−05	1.61
410382	AW664971	Hs. 259546	ESTs	5.40E−05	1.61
421410	AI472323	Hs. 134353	ESTs	7.65E−05	1.61
438176	AW138970	Hs. 144759	ESTs	7.85E−05	1.61
404584			Target Exon	3.42E−03	1.61
422423	AF283777	Hs. 116481	CD72 antigen	1.72E−03	1.61
441894	AA134329		Homo sapiens, clone IMAGE: 3685398, mRNA,	7.36E−04	1.61
421801	AI431597	Hs. 284294	Breakpoint cluster region protein, uteri	2.69E−05	1.61
428379	X06026	Hs. 2259	CD3G antigen, gamma polypeptide (TiT3 co	8.68E−05	1.61
451788	BE242857	Hs. 27021	hypothetical protein FLJ11159	2.35E−06	1.61
444708	AW971049	Hs. 11774	protein (peptidyl-prolyl cis/trans isome	9.22E−05	1.61
442358	BE567985	Hs. 18585	ESTs, Moderately similar to ALU4_HUMAN A	3.12E−06	1.60
422521	AW363324	Hs. 126906	hypothetical protein FLJ 12598	1.19E−07	1.60
428475	AF172940	Hs. 184542	CGI-127 protein	1.11E−06	1.60
449027	AJ271216	Hs. 22880	dipeptidylpeptidase III	7.55E−04	1.60
404240			NM_018950: Homo sapiens major histocompat	3.66E−09	1.60
414792	BE314949	Hs. 87128	hypothetical protein FLJ23309	1.12E−08	1.60
416747	AW876523	Hs. 15929	hypothetical protein FLJ12910	9.45E−06	1.60
418001	R80582	Hs. 24625	ESTs	1.62E−03	1.60
433009	AA761668		gb: nz24c08.s1 NCI_CGAP_GCB1 Homo sapiens	6.37E−03	1.60
421016	AA504583	Hs. 101047	transcription factor 3 (E2A immunoglobul	9.01E−06	1.60
436256	T87113	Hs. 193825	ESTs	1.46E−04	1.60
428418	AI368826	Hs. 8768	ESTs	1.04E−06	1.60
451253	H48299	Hs. 26126	claudin 10	1.22E−03	1.60
425913	AA365799		SEC22, vesicle trafficking protein (S. c	1.11E−06	1.60
418460	M26315	Hs. 85258	CD8 antigen, alpha polypeptide (p32)	4.30E−04	1.60
420680	AA648758	Hs. 187791	ESTs	2.56E−04	1.60
425691	NM_005328	Hs. 159226	hyaluronan synthase 2	3.04E−03	1.60
446307	T50083	Hs. 22247	ESTs	5.05E−03	1.60
422805	AA436989	Hs. 121017	H2A histone family, member A	2.11E−05	1.60
420092	AA814043	Hs. 88045	ESTs	2.86E−03	1.59
443959	AL120546		gb: DKFZp761A069_r1 761 (synonym: hamy2)	3.44E−04	1.59
404409			C8001172*: gi|10432395|emb|CAC10285.1| (A	5.86E−04	1.59
405601			Target Exon	5.21E−04	1.59
431543	AW969619	Hs. 259768	adenylate cyclase 1 (brain)	1.20E−03	1.59
428826	AL048842	Hs. 194019	atlractin	3.04E−07	1.59
439498	AA908731	Hs. 58297	CLLL8 protein	2.01E−04	1.59
438661	AA813539	Hs. 123414	ESTs, Weakly similar to I37570 zinc fing	7.79E−06	1.59
447105	AW377610	Hs. 11123	DKFZP564G092 protein	2.19E−05	1.59
412983	AI478828	Hs. 16570	ESTs, Weakly similar to I38022 hypotheti	6.13E−05	1.59
440764	AA905406	Hs. 9905	ESTs, Weakly similar to unnamed protein	1.78E−03	1.59
452806	AW014549	Hs. 58373	ESTs	4.21E−04	1.59
404919			ENSP00000237577*: Polycystin 2 (Autosomal	5.59E−03	1.59
424737	BE301883	Hs. 152707	glioblastoma amplified sequence	7.59E−05	1.59
435205	X54136	Hs. 181125	immunoglobulin lambda locus	5.77E−03	1.59
403738			C4000675*: gi|3426332|gb|AAC32272.1| (AF0	4.04E−09	1.59
408705	AA312135	Hs. 46967	HSPCO34 protein	7.26E−09	1.59
431377	AW178807	Hs. 246182	ESTs	2.46E−03	1.58
433359	H70007		gb: yr89e07.r1 Soares fetal liver spleen	2.39E−03	1.58
447809	AW207605	Hs. 164230	ESTs, Highly similar to JC7266 3′,5′-cyc	3.29E−08	1.58
415938	BE383507	Hs. 78921	A kinase (PRKA) anchor protein 1	1.35E−06	1.58
434375	BE277910	Hs. 3833	3′-phosphoadenosine 5′-phosphosulfate sy	7.89E−08	1.58
408412	AW193033	Hs. 124436	ESTs	9.63E−04	1.58
419672	AA465113	Hs. 23853	ESTs, Weakly similar to A34615 profilagg	4.60E−04	1.58
435931	AI077464		RNA binding motif protein 9	1.37E−04	1.58
432645	014041	Hs. 347340	H-2K binding factor-2	3.91E−03	1.58
412886	AF041163	Hs. 74647	Human T-cell receptor active alpha-chain	3.77E−06	1.58
424696	BE439547	Hs. 151903	GrpE-like protein cochaperone	2.03E−04	1.57
446725	AL050173	Hs. 16007	chromosome 21 open reading frame 25	1.32E−05	1.57
439788	N71241	Hs. 119275	ESTs	1.99E−03	1.57
431736	AI912234	Hs. 3297	ribosomal protein S27a	2.14E−05	1.57
449368	AW009668	Hs. 232284	ESTs	1.48E−03	1.57
452866	R26969	Hs. 268016	Homo sapiens cDNA: FLJ21243 fis, clone C	4.10E−05	1.57
429586	T73510	Hs. 209153	angiopoietin-like 3	4.09E−07	1.57
453887	BE564037	Hs. 36237	hypothetical protein	4.59E−06	1.57
428759	AC007059	Hs. 193065	hypothetical protein DKFZp547M136 simila	8.66E−06	1.57
401847			C17000828: gi|1666071|emb|CAA69174.1| (Y0	6.56E−05	1.57
434747	M837085		ESTs	4.24E−03	1.57
449601	AA461509	Hs. 293565	ESTs, Weakly similar to putative p150 [H	4.36E−05	1.57
457758	AI475671	Hs. 88607	ESTs, Highly similar to F-box protein FB	3.83E−04	1.57
447574	AF162666	Hs. 18895	tousled-Iike kinase 1	7.59E−07	1.57
401928			Target Exon	2.68E−03	1.57
406274			Target Exon	6.32E−05	1.56
449291	BE176893	Hs. 23440	KIAA1105 protein	1.17E−06	1.56
429280	AI445960	Hs. 3685	hypothetical protein FLJ20209	5.66E−09	1.56
419946	AI298508	Hs. 18963	ESTs	1.24E−04	1.56
439008	AF075072	Hs. 167535	ESTs, Weakly similar to ALU1_HUMAN ALU S	3.38E−03	1.56
444756	AA278501	Hs. 200332	hypothetical protein FLJ20651	5.36E−03	1.56
425409	H18021	Hs. 25005	hypothetical protein MGC3329	1.55E−03	1.56
453387	AI990741	Hs. 252809	ESTs	5.19E−04	1.56
438156	Z20244	Hs. 192906	ESTs	3.43E−05	1.56
401558			ENSP00000220478*: SECRETOGRANIN III.	1.17E−04	1.56
420807	M280627	Hs. 57846	ESTs	6.07E−04	1.56
434942	M021562	Hs. 347950	Homo sapiens. Similar to nuclear localiz	3.13E−06	1.55
444479	AA194980	Hs. 30818	Homo sapiens cDNA FLJ13681 fis. clone PL	2.39E−03	1.55
444078	BE246919	Hs. 10290	U5 snRNP-specific 40 KDa protein (hPrp8-	6.70E−04	1.55
421612	AF161254	Hs. 106196	8D6 antigen	7.97E−10	1.55
432740	AF061034	Hs. 278898	tumor necrosis factor alpha-inducible ce	1.66E−07	1.55
456563	AA989220	Hs. 766	ESTs	1.09E−04	1.55
420573	AA278407	Hs. 88528	ESTs	4.79E−03	1.55
437998	U92025	Hs. 200680	ESTs, Moderately similar to KIAA0573 pro	3.78E−03	1.55
423570	AW838306	Hs. 129819	hypothetical protein FLJ11160	2.25E−05	1.55
425356	BE244879	Hs. 155939	inositol polyphosphate-5-phosphatase, 14	6.94E−04	1.55
443661	AA336609	Hs. 10862	Homo sapiens cDNA: FLJ23313 fis, clone H	1.04E−04	1.55
433878	AA613245	Hs. 259181	ESTs	4.25E−04	1.55
449337	AW772245	Hs. 223978	ESTs	2.97E−05	1.55
434608	AA805443	Hs. 179909	hypothetical protein FLJ22995	3.60E−04	1.55
418310	AA814100	Hs. 86693	ESTs	9.87E−04	1.54
436388	AI806172	Hs. 166486	Homo sapiens cDNA FLJ11432 fis, clone HE	4.35E−06	1.54
417848	AA206581	Hs. 116586	ESTs, Weakly similar to JC5314 CDC28/cdc	1.02E−05	1.54
435438	H84421	Hs. 4890	ubiquitin-conjugating enzyme E2E 3 (homo	2.83E−04	1.54
427790	NM_002887	Hs. 180832	hypothetical protein MGC8641	2.02E−05	1.54
442968	AK000606	Hs. 8868	golgi SNAP receptor complex member 1	3.73E−09	1.54
416727	W05023		gb: za45a11.ri Soares fetal liver spleen	4.98E−03	1.54
440201	AL359588	Hs. 7041	hypothetical protein DKFZp762B226	4.87E−04	1.54
415670	AA166633	Hs. 117183	gb: zq39b01.r1 Stratagene hNT neuron (937	4.54E−04	1.54
408380	AF123050	Hs. 44532	diubiquitin	3.89E−09	1.54
403746			ENSP00000226812*: KIAA1494 protein (Fragm	9.67E−04	1.53
420172	AA601122	Hs. 95655	secreted and transmembrane 1	5.53E−03	1.53
415200	AL040328	Hs. 78202	SWI/SNF related, matrix associated, acti	6.23E−08	1.53
441488	AW450935	Hs. 7862	hypothetical protein FLJ20312	7.06E−07	1.53
413859	AW992356	Hs. 8364	Homo sapiens pyruvate dehydrogenase kina	1.25E−04	1.53
425601	AW629485	Hs. 140720	GSK-3 binding protein FRAT2	1.63E−06	1.53
439704	AW020018	Hs. 293267	ESTs	2.65E−05	1.53
409344	R47279	Hs. 285673	hypothetical protein FLJ20950	2.38E−06	1.53
424602	AK002055	Hs. 151046	hypothetical protein FLJ11193	1.23E−04	1.53
429556	AW139399	Hs. 98988	ESTs	2.67E−03	1.53
446756	AW028485	Hs. 26136	hypothetical protein MGC14156	5.35E−07	1.53
418827	BE327311	Hs. 47166	HT021	1.00E−05	1.53
438204	AI589645	Hs. 128690	ESTs	2.96E−04	1.53
417377	NM_016603	Hs. 82035	potential nuclear protein C5ORF5; GAP-li	3.15E−08	1.52
422536	AA311915	Hs. 187726	gb: EST182621 Jurkat T-cells VI Homo sapi	6.56E−05	1.52
431945	AW000827	Hs. 11962	apoptosis regulator BCL-G	3.53E−03	1.52
421025	AW958975	Hs. 29397	Homo sapiens cDNA FLJ13226 fis. clone OV	7.11E−06	1.52
444652	BE513613	Hs. 11538	actin related protein 2/3 complex, subun	7.17E−03	1.52
458345	AI864078	Hs. 144076	ESTs	3.45E−04	1.52
425692	D90041	Hs. 155956	N-acetyltransferase 1 (arylamine N-acety	2.04E−06	1.52
400120			Eos Control	8.78E−04	1.52
440591	AA431599	Hs. 132799	hypothetical protein FLJ23451	7.90E−05	1.52
412826	BE001722	Hs. 14877	ESTs, Weakly similar to (defline not ava	1.45E−03	1.52
408683	R58665	Hs. 46847	TRAF and TNF receptor-associated protein	2.29E−09	1.52
424852	AI222779	Hs. 144848	ESTs	9.90E−03	1.52
423694	NM_003747	Hs. 131814	tankyrase, TRF1-interacting ankyrin-rela	2.70E−08	1.52
432134	AI816782	Hs. 122583	hypothetical protein FLJ21934	7.31E−06	1.52
447131	NM_004585	Hs. 17466	retinoic acid receptor responder (tazaro	3.80E−06	1.52
427212	AW293849	Hs. 58279	ESTs, Weakly similar to ALU7_HUMAN ALU S	4.87E−06	1.52
423524	AF055989	Hs. 129738	potassium voltage gated channel, Shaw-re	4.04E−04	1.52
457933	AA759062	Hs. 121434	ESTs	1.63E−03	1.52
425769	U72513	Hs. 159486	Human RPL13-2 pseudogene mRNA, complete	3.40E−06	1.51
431262	NM_006672	Hs. 251395	solute carrier family 22 (organic anion	6.08E−05	1.51
457764	AW028284	Hs. 4815	nudix (nucleoside diphosphate linked moi	3.11E−04	1.51
438712	AW978161	Hs. 268555	5′-3′ exoribonuclease 2	1.00E−03	1.51
420514	N32301	Hs. 102496	ESTs	6.01E−04	1.51
410972	AW812259		gb: RC0-ST0174-191099-031-b05 ST0174 Homo	2.97E−03	1.51
446493	AK001389	Hs. 15144	hypothetical protein DKFZp564O043	2.66E−06	1.51
415000	AW025529	Hs. 239812	Homo sapiens serologically defined breas	8.80E−08	1.51
427647	W19744	Hs. 180059	Homo sapiens cDNA FLJ20653 fis, clone KA	7.28E−06	1.50
409022	BE222648	Hs. 241432	ESTs, Highly similar to C380A1.1b [H. sap	3.80E−06	1.50
441980	AK001441	Hs. 8055	hypothetical protein FLJ10579	1.53E−03	1.50
445424	AB028945	Hs. 12696	cortactin SH3 domain-binding protein	9.78E−07	1.50
414948	C15240	Hs. 182155	ESTs	2.68E−06	1.50
442878	AI868648	Hs. 22315	ESTs	7.00E−05	1.50
438021	AV653790		WW domain-containing protein 1	1.28E−06	1.50
426723	AW003069	Hs. 183860	ESTs	7.02E−06	1.50
420847	AI356920	Hs. 23510	ESTs	2.14E−03	1.50
406972	M32053		gb: Human H19 RNA gene, complete cds.	6.00E−03	1.50
445309	AL157474	Hs. 12504	likely ortholog of mouse Arkadia	3.14E−05	1.50
421712	AK000140	Hs. 107139	hypothetical protein	9.42E−09	1.50
414091	T83742	Hs. 334616	gb: yd67g02.s1 Soares fetal liver spleen	2.35E−05	1.50
402945			Target Exon	1.02E−03	1.50
400487			ENSP00000238977*: lnterferon-induced prot	1.77E−04	1.50
438308	AI343469	Hs. 127685	KIAA1627 protein	7.96E−06	1.50
411227	AW833258		gb: RC2-TT0007-131099-011-b10_1 TT0007 Ho	7.01E−04	1.50
451452	BE560065	Hs. 26433	dolichyl-phosphate(UDP-N-acetylglucosam	1.34E−04	1.49
451806	NM_003729	Hs. 27076	RNA 3′-terminal phosphate cyclase	1.25E−04	1.49
424924	AL039103	Hs. 153834	pumilio (Drosophila) homolog 1	3.26E−06	1.49
452136	AU076713	Hs. 479	RAB5C, member RAS oncogene family	4.25E−03	1.49
439375	AA689526	Hs. 344249	steroid dehydrogenase homolog	3.64E−06	1.49
410177	NM_015425	Hs. 59475	DKFZP586M0122 protein	1.00E−03	1.49
407813	AL120247	Hs. 40109	KIAA0872 protein	1.86E−05	1.49
420505	AW967984	Hs. 122552	G-2 and S-phase expressed 1	4.16E−03	1.49
456373	BE247706	Hs. 89751	membranE−spanning 4-domains, subfamily A	4.10E−03	1.49
412853	M34175	Hs. 74626	adaptor-related protein complex 2, beta	2.89E−04	1.49
434369	AI650363	Hs. 116462	ESTs	1.34E−03	1.49
442751	AI358404		gb: qw20f03.x1 NCI_CGAP_Ut3 Homo sapiens	2.61E−05	1.49
442432	BE093589	Hs. 38178	hypothetical protein FLJ23468	3.18E−06	1.49
408784	AW971350	Hs. 63386	ESTs	9.38E−05	1.49
449629	AA031547	Hs. 298442	adaptor-related protein complex 3, mu 1	4.62E−05	1.49
419110	AA234171	Hs. 187626	ESTs	2.44E−04	1.49
457238	U07358	Hs. 211601	mitogen-activated protein kinase kinase	2.21E−03	1.49
408483	AA464836	Hs. 291079	ESTs, Weakly similar to T27173 hypotheti	5.75E−07	1.49
456633	AW139036	Hs. 108957	40S ribosomal protein S27 isoform	6.06E−04	1.48
450746	D82673	Hs. 278589	general transcription factor II, i	1.58E−09	1.48
438637	BE500941	Hs. 126730	ESTs, Weakly similar to KIAA1214 protein	1.08E−03	1.48
444775	AI040384	Hs. 19102	ESTs, Weakly similar to organic anion tr	1.50E−07	1.48
426335	AI054347	Hs. 2017	ribosomal protein L38	6.98E−03	1.48
450253	AL133047	Hs. 24715	Homo sapiens mRNA; cDNA DKFZp434D0215 (f	4.78E−05	1.48
434466	AB037829	Hs. 3862	regulator of nonsense transcripts 2; DKF	2.91E−06	1.48
446164	AW273539		hypothetical protein FLJ23577	3.00E−03	1.48
458533	AA314487	Hs. 11123	DKFZP564G092 protein	7.99E−05	1.48
450377	AB033091		KIAA1265 protein	7.22E−05	1.48
411798	AW864049	Hs. 133505	gb: PM2-SN0013-120400-003-c06 SN0013 Homo	1.10E−03	1.48
419715	AF070523	Hs. 92384	vitamin A responsive; cytoskeleton relat	4.88E−07	1.48
422611	AA158177	Hs. 118722	fucosyltransferase 8 (alpha (1, 6) fucosy	1.93E−06	1.48
453186	AK001708	Hs. 32271	hypothetical protein FLJ10846	3.21E−04	1.48
403330			Target Exon	4.62E−05	1.47
447095	AI361424	Hs. 265174	ESTs	1.74E−03	1.47
445175	AV652851	Hs. 20255	ESTs	3.04E−05	1.47
406868	AA505445	Hs. 300697	immunoglobulin heavy constant gamma 3 (G	1.24E−04	1.47
424683	N87519	Hs. 27196	ESTs	1.58E−05	1.47
453394	AW960474	Hs. 40289	ESTs	5.61E−06	1.47
416744	AL135579	Hs. 79709	phosphotidylinositol transfer protein	3.24E−07	1.47
416206	AW206248	Hs. 111092	hypothetical protein FLJ22332	1.53E−09	1.47
400975			Target Exon	1.06E−03	1.47
452068	W76412	Hs. 57877	ESTs	1.45E−04	1.47
444985	AI677737	Hs. 28329	hypothetical protein FLJ14005	3.04E−05	1.47
430945	U80669	Hs. 55999	NK homeobox (Drosophila), family 3. A	1.72E−05	1.47
424180	AB032987	Hs. 320861	KIAA1161 protein	1.08E−04	1.47
446189	H85224	Hs. 214013	ESTs	4.67E−05	1.47
433991	AA912749		ESTs	7.45E−03	1.47
412972	AA771898	Hs. 33412	ESTs	2.53E−03	1.47
433418	AA587831	Hs. 87134	ESTs	2.47E−03	1.47
429520	AA160142	Hs. 205058	hypothetical protein FLJ20075	2.48E−03	1.46
452852	AK001972	Hs. 30822	hypothetical protein FLJ11110	1.77E−08	1.46
419083	AI479560	Hs. 98613	Homo sapiens cDNA FLJ12292 fis. clone MA	5.14E−06	1.46
422643	D42045	Hs. 1560	DNA-crosslink repair gene SNM1	2.05E−04	1.46
421965	AA301100	Hs. 346482	gb: EST14128 Testis tumor Homo sapiens cD	1.07E−06	1.46
448277	BE622827	Hs. 99486	hypothetical protein FLJ13044	1.67E−07	1.46
423979	AF229181	Hs. 136644	CS box-containing WD protein	1.77E−03	1.46
459169	AI905517		gb: RC-BT091-210199-105 BT091 Homo sapien	1.19E−03	1.46
442220	AL037800	Hs. 8148	selenoprotein T	1.41E−05	1.46
407807	AL031427	Hs. 40094	Human DNA sequence from clone 167A19 on	5.25E−04	1.46
426642	AW068223	Hs. 171581	ubiquitin C-terminal hydrolase UCH37	4.71E−06	1.46
442348	BE315496	Hs. 8258	DKFZP434D1335 protein	1.18E−03	1.46
443487	AI073491	Hs. 269887	ESTs, Highly similar to KPBB_HUMAN PHOSP	1.03E−03	1.46
419586	AI088485	Hs. 144759	ESTs, Weakly similar to I38022 hypotheti	6.52E−08	1.46
433514	AW183734	Hs. 189782	hypothetical protein FLJ10747	7.13E−04	1.46
417321	N68722	Hs. 191368	ESTs	6.13E−04	1.46
408521	AA055264	Hs. 260848	ESTs, Weakly similar to S23650 retroviru	7.91E−07	1.45
438510	AL080220	Hs. 6285	DKFZP586P0123 protein	1.59E−05	1.45
441458	AW815108		gb: QV4-ST0212-091199-023-h01 ST0212 Homo	4.05E−04	1.45
420568	F09247	Hs. 247735	protocadherin alpha 10	1.65E−05	1.45
431186	NM_012249	Hs. 250697	ras-like protein	4.34E−07	1.45
451987	AA815092	Hs. 77554	Homo sapiens cDNA FLJ14967 fis, clone TH	6.89E−04	1.45
419998	AA252691	Hs. 346200	gb: zs26d09.r1 NCI_CGAP_GCB1 Homo sapiens	2.32E−03	1.45
421272	AA704157		ESTs	2.59E−04	1.45
400200			NM_002788*: Homo sapiens proteasome (pros	7.15E−05	1.45
400440	X83957	Hs. 83870	nebulin	3.35E−03	1.45
444654	AV650572	Hs. 23440	KIAA1105 protein	6.77E−06	1.45
446793	AW590131	Hs. 156468	ESTs	5.34E−03	1.45
445919	T53519	Hs. 334692	hypothetical protein MGC14141	5.08E−03	1.45
433422	AW976627	Hs. 284294	Breakpoint cluster region protein, uteri	2.98E−07	1.45
421721	AB037799	Hs. 107279	KIAA1378 protein	4.59E−03	1.45
444913	AI362726	Hs. 193656	Homo sapiens mRNA for KIAA1658 protein,	1.15E−06	1.45
421957	AW068637	Hs. 109857	hypothetical protein DKFZp434H0820	8.29E−03	1.45
412935	BE267045	Hs. 75064	tubulin-specific chaperone c	4.27E−08	1.44
413884	AI668892	Hs. 239758	hypothetical protein FLJ12389 similar to	1.04E−04	1.44
417961	Z44190	Hs. 83023	peroxisomal biogenesis factor 11B	1.35E−07	1.44
442619	AA447492	Hs. 20183	ESTs, Weakly similar to AF164793 1 prote	3.67E−06	1.44
439894	AA853077	Hs. 300697	immunoglobulin heavy constant gamma 3 (G	7.44E−03	1.44
422241	Y00062	Hs. 170121	protein tyrosine phosphatase, receptor t	1.57E−08	1.44
407687	AK002011	Hs. 37558	hypothetical protein FLJ11149	8.19E−04	1.44
427929	BE613835	Hs. 181159	Homo sapiens mRNA; cDNA DKFZp434F0217 (f	2.28E−05	1.44
410054	AL120050	Hs. 58220	Homo sapiens cDNA: FLJ23005 fis, clone L	1.21E−03	1.44
443639	BE269042	Hs. 9661	proteasome (prosome, macropain) subunit,	4.08E−07	1.44
449437	AI702038	Hs. 100057	Homo sapiens cDNA: FLJ22902 fis, clone K	2.51E−05	1.44
406918	M88357		gb: Homo sapiens DNA-binding protein (ZNF	6.10E−03	1.44
424286	AA338285	Hs. 90744	proteasome (prosome, macropain) 26S subu	2.50E−07	1.44
425261	BE385099		hypothetical protein MGC3017	1.12E−04	1.44
452822	X85689	Hs. 288617	hypothetical protein FLJ22621	6.51E−04	1.44
425289	AW139342	Hs. 155530	interferon, gamma-inducible protein 16	8.16E−06	1.44
428894	AA437066	Hs. 271736	ESTs	2.54E−03	1.44
418533	NM_004533	Hs. 85937	myosin-binding protein C, fast-type	8.68E−03	1.43
411030	BE387193	Hs. 67896	7-60 protein	8.65E−06	1.43
435882	AW194987		ESTs	2.85E−04	1.43
444773	BE156256	Hs. 11923	hypothetical protein	6.80E−03	1.43
435522	N64214	Hs. 9774	synovial sarcoma translocation gene on c	2.42E−07	1.43
400552			Target Exon	2.09E−04	1.43
449103	T24968	Hs. 23038	HSPC071 protein	6.24E−06	1.43
411492	T46848	Hs. 70337	immunoglobulin superfamily, member 4	2.14E−06	1.43
450456	AA600192		ESTs, Weakly similar to ALUB_HUMAN !!!!	6.66E−06	1.43
440515	AJ131245	Hs. 7239	SEC24 (S. cerevisiae) related gene famil	3.40E−03	1.43
434924	AA443164	Hs. 23259	hypothetical protein FLJ13433	7.81E−07	1.43
439981	AI348408	Hs. 124675	ESTs, Weakly similar to T14742 hypotheti	3.16E−07	1.43
452268	NM_003512	HS. 28777	H2A histone family, member L	6.16E−09	1.43
408358	D20044	Hs. 12929	hypothetical protein FLJ20721	2.62E−04	1.42
446755	AW451473	Hs. 16134	serine/threonine kinase 10	1.34E−03	1.42
435772	AA700019	Hs. 132992	ATP-binding cassette, sub-family G (WHIT	1.62E−05	1.42
457250	AA811987	Hs. 125779	ESTs	5.09E−03	1.42
415192	D17793	Hs. 78183	aldo-keto reductase family 1, member C3	1.35E−05	1.42
418506	AA084248	Hs. 85339	G protein-coupled receptor 39	1.28E−03	1.42
407972	AA827639	Hs. 18587	KIAA1588 protein	8.57E−03	1.42
452718	AI762301	Hs. 44017	sirtuin (silent mating type information	1.90E−04	1.42
443325	BE398006	Hs. 90462	Homo sapiens, clone IMAGE: 4132043, mRNA,	3.44E−03	1.42
422040	AA172106	Hs. 110950	Rag C protein	9.07E−05	1.42
442296	NM_007275	Hs. 8186	lung cancer candidate	1.13E−05	1.42
418475	AI858732	Hs. 30443	sentrin/SUMO-specific protease	1.94E−04	1.42
403147			Target Exon	4.29E−03	1.42
452647	N29495	Hs. 96870	staufen (Drosophila, RNA-binding protein	4.56E−03	1.42
415049	N67334	Hs. 50158	ESTs	1.54E−03	1.41
406605			Target Exon	9.18E−05	1.41
434152	AI792665	Hs. 291190	ESTs	1.11E−03	1.41
433307	AI393009	Hs. 153385	hypothetical protein MGC5509	6.73E−04	1.41
414245	BE148072	Hs. 75850	WAS protein family, member 1	1.25E−03	1.41
419407	AW410377	Hs. 41502	hypothetical protein FLJ21276	2.41E−07	1.41
414548	AW937036	Hs. 183506	hypothetical protein FLJ14213	5.51E−04	1.41
421958	AA357185	Hs. 109918	ras homolog gene family, member H	3.31E−04	1.41
450122	BE313765		ESTs, Weakly similar to I38022 hypotheti	6.86E−06	1.41
445308	AW975748	Hs. 5724	sclerostin	5.31E−05	1.41
434045	AI065133	Hs. 152316	hypothetical protein PRO0971	1.76E−04	1.41
423262	NM_005479	Hs. 126057	frequently rearranged in advanced T-cell	1.49E−07	1.41
451413	AA448974	Hs. 26367	PC3-96 protein	1.90E−06	1.41
434978	AA321238	Hs. 4310	eukaryotic translation initiation factor	2.64E−03	1.41
417100	AI828908	Hs. 4552	ubiquilin 2	1.80E−04	1.41
445692	AI248322	Hs. 182099	ESTs	2.29E−05	1.41
436486	AA742221	Hs. 120633	ESTs	3.93E−03	1.41
441976	AA428403	Hs. 106131	ESTs	1.08E−05	1.41
445530	BE294791		hypothetical protein FLJ12666	3.72E−04	1.41
402907			NM_024777*: Homo sapiens hypothetical pro	9.75E−03	1.41
419165	AW860767	Hs. 118879	ESTs	1.90E−03	1.41
406815	AA833930		tRNA isopentenylpyrophosphate transferas	1.03E−03	1.41
421726	AK001237	Hs. 319088	hypothetical protein FLJ10375	1.04E−07	1.41
437392	AL359943	Hs. 132272	Homo sapiens mRNA; cDNA DKFZp762D186 (fr	3.68E−03	1.41
439128	AI949371	Hs. 13854	ESTs	9.06E−06	1.41
457393	AW970603		gb: EST382684 MAGE resequences, MAGK Homo	7.71E−03	1.40
449975	BE546004	Hs. 22350	hypothetical protein LOC56757	8.49E−04	1.40
451436	W86497		KIAA0729 protein	9.49E−05	1.40
429490	AI971131	Hs23889	ESTs, Weakly similar to ALU7_HUMAN ALU S	2.97E−06	1.40
454117	BE410100	Hs. 40368	adaptor-related protein complex 1, sigma	5.93E−04	1.40
401431			Target Exon	1.27E−03	1.40
442445	AA082665	Hs. 209561	KIAA1715 protein	1.22E−04	1.40
410297	AA148710		lumican	3.82E−08	1.40
444960	AI611317	Hs. 341531	ESTs	6.84E−07	1.40
418835	AL023694	Hs. 88977	hypothetical protein dJ511E16.2	1.04E−05	1.40
446178	AI278844	Hs. 149450	ESTs	2.18E−04	1.40
430299	W28673	Hs. 106747	serine carboxypeptidase 1 precursor prot	8.74E−05	1.40
420790	L04791	Hs. 99924	excision repair cross-complementing rode	5.78E−03	1.40
427701	AA411101	Hs. 243886	nuclear autoantigenic sperm protein (his	3.52E−04	1.40
433225	AW816515	Hs. 173540	ATPase, Class V, type 10D	9.45E−05	1.40
444670	H58373	Hs. 332938	hypothetical protein MGC5370	1.04E−05	1.40
435099	AC004770	Hs. 4756	flap structure-specific endonuclease 1	1.89E−03	1.40
446291	BE397753	Hs. 14623	interferon, gamma-inducible protein 30	1.32E−03	1.40
417628	T84214		gb: yd32f10.r1 Soares fetal liver spleen	2.53E−05	1.40
428820	AA436187	Hs. 172631	integrin, alpha M (complement component	2.63E−06	1.39
438356	AA805530	Hs. 48527	ESTs	7.22E−03	1.39
422310	AA316622	Hs. 98370	cytochrome P450, subfamily IIS, polypept	2.06E−05	1.39
441149	AI569766	Hs. 13205	ESTs	2.12E−03	1.39
443490	AB018313	Hs. 9452	KIAA0770 protein	1.66E−07	1.39
425272	AA354138	Hs. 47209	ESTs, Weakly similar to C35826 hypotheti	3.57E−03	1.39
443037	AW500305	Hs. 8906	syntaxin 7	1.61E−05	1.39
409330	AK001231	Hs. 53940	hypothetical protein FLJ10369	9.63E−04	1.39
408822	AW500715	Hs. 57079	Homo sapiens cDNA FLJ13267 fis, clone OV	2.44E−06	1.39
426809	BE313114	Hs. 29706	ESTs	2.91E−05	1.39
416197	AA176253	Hs. 110309	major histocompatibility complex, class	2.96E−07	1.39
410334	AW979261	Hs. 291993	ESTs	5.81E−05	1.39
422645	L40027	Hs. 118890	glycogen synthase kinase 3 alpha	3.13E−05	1.39
414931	AK000342	Hs. 77646	Homo sapiens mRNA; cDNA DKFZp761M0223 (f	2.07E−04	1.39
434809	AW974687		gb: EST386776 MAGE resequences, MAGM Homo	6.88E−03	1.39
421315	D78791	Hs. 103419	fasciculation and elongation protein zet	4.60E−07	1.39
420985	X94703		RAB28, member RAS oncogene family	8.20E−05	1.39
422653	AI092590	Hs. 118962	far upstream element (FUSE) binding prot	1.20E−03	1.39
401047			Target Exon	5.92E−03	1.39
408417	AI124541	Hs. 44720	hypothetical protein P1 p373c6	3.93E−04	1.39
415130	W85893	Hs. 249867	ESTs	1.44E−05	1.39
447511	BE274845	Hs. 17110	Homo sapiens mRNA; cDNA DKFZp434C2016 (f	9.71E−03	1.39
421970	AF227156	Hs. 110103	RNA polymerase l transcription factor RR	9.45E−04	1.38
414733	BE514535	Hs. 77171	minichromosome maintenance deficient (S.	8.98E−06	1.38
451107	AA235108	Hs. 17639	Homo sapiens ubiquitin protein ligase (U	1.06E−04	1.38
428104	AA421350		ESTs	1.62E−04	1.38
435124	AA725362	Hs. 120456	ESTs	2.46E−04	1.38
423558	AW865643	Hs. 275865	ribosomal protein S18	7.10E−05	1.38
430933	AW863635		gb: MR3-SN0010-270300-103-h02 SN0010 Homo	1.88E−03	1.38
419511	AA429750	Hs. 75113	general transcription factor IIIA	3.02E−05	1.38
423787	AJ295745	Hs. 236204	nuclear pore complex protein	2.58E−04	1.38
438441	AW664960	Hs. 205319	ESTs	5.62E−05	1.38
457186	AW371847	Hs. 313499	ESTs	2.77E−04	1.38
444388	AB033058	Hs. 11101	KIAA1232 protein	2.86E−03	1.38
419135	R61448	Hs. 106728	ESTs, Weakly similar to KIAA1353 protein	1.43E−08	1.38
417386	AL037228	Hs. 82043	D123 gene product	7.23E−04	1.38
444363	AI142827	Hs. 143656	ESTs	8.10E−05	1.38
447829	AI433029	Hs. 164104	ESTs	7.35E−03	1.38
434848	BE256304	Hs. 32148	AD-015 protein	1.74E−03	1.38
443186	AI885827	Hs. 7149	ESTs, Weakly similar to T13963 formin re	1.89E−03	1.38
436563	AJ239450	Hs. 157874	ESTs	1.04E−04	1.38
414176	BE140638	Hs. 75794	EDG-2 (endothelial differentiation, lys	6.98E−03	1.38
413771	AA810047	Hs. 4112	acetyl-Coenzyme A acetyltransferase 2 (a	3.74E−04	1.38
430027	AB023197	Hs. 227743	KIAA0980 protein	3.32E−09	1.38
432403	AA550815	Hs. 124840	ESTs	1.03E−05	1.37
454038	X06374	Hs. 37040	platelet-derived growth factor alpha pol	2.84E−03	1.37
409593	AB032985	Hs. 55069	neurexophilin 3	7.75E−04	1.37
408124	U89337	Hs. 42853	cAMP responsive element binding protein-	4.40E−07	1.37
457062	AA404520	Hs. 125845	ribulose-5-phosphate-3-epimerase	8.18E−04	1.37
434894	AW977850	Hs. 23856	hypothetical protein MGC5297	4.62E−03	1.37
456619	AV647917	Hs. 107153	inhibitor of growth family, member 1-lik	1.49E−08	1.37
447811	C15005	Hs. 17121	ESTs, Moderately similar to GRPM MOUSE G	2.97E−04	1.37
421662	NM_014141	Hs. 106552	cell recognition molecule Caspr2	1.32E−03	1.37
411678	AI907114	Hs. 71465	squalene epoxidase	7.96E−04	1.37
411352	NM_002890	Hs. 758	RAS p21 protein activator (GTPase activa	2.60E−05	1.37
420962	NM_005904	Hs. 100602	MAD (mothers against decapentaplegic, Dr	2.22E−07	1.37
408388	AF091086	Hs. 44563	hypothetical protein	1.02E−04	1.37
438517	AI439688	Hs. 6289	hypothetical protein FLJ20886	4.50E−05	1.37
404813			Target Exon	1.79E−03	1.37
448361	H82028	Hs. 238707	hypothetical protein FLJ22457	1.29E−04	1.37
441077	AI241273	Hs. 15312	ESTs	5.25E−08	1.36
459190	AW410601	Hs. 30026	HSPC182 protein	2.26E−04	1.36
421297	AB037360		KIAA1255 protein	1.33E−07	1.36
417929	R27219	Hs. 74647	Human T-cell receptor active alpha-chain	9.13E−05	1.36
421983	AI252640	Hs. 110364	peptidylprolyl isomerase C (cyclophilin	4.89E−06	1.36
444842	AF084479	Hs. 194688	bromodomain adjacent to zinc finger doma	1.24E−05	1.36
423485	AB037809	Hs. 129268	KIAA1388 protein	2.34E−03	1.36
446110	AI305223	Hs. 148056	ESTs	3.07E−04	1.36
435635	AF220050	Hs. 181385	uncharacterized hematopoietic stem/proge	1.29E−04	1.36
408360	AI806090	Hs. 44344	hypothetical protein FLJ20534	1.33E−08	1.36
412622	AW664708	Hs. 171959	ESTs	9.40E−03	1.36
414718	H95348	Hs. 107987	ESTs	1.35E−03	1.36
444886	AW340504	Hs. 148557	ESTs	1.75E−03	1.36
449188	AW072939	Hs. 347187	myotubularin related protein 1	6.45E−07	1.36
410804	U64820	Hs. 66521	Machado-Joseph disease (spinocerebellar	2.44E−04	1.36
400296	AA305627	Hs. 139336	ATP-binding cassette, sub-family C (CFTR	3.61E−03	1.36
427080	AW068287	Hs. 301175	ras-related C3 botulinum toxin substrate	6.15E−05	1.36
452934	AA581322	Hs. 4213	hypothetical protein MGC16207	4.31E−05	1.36
409353	NM_006858	Hs. 54411	putative T1/ST2 receptor binding protein	7.85E−05	1.36
410426	AA085039	Hs. 285013	putative human HLA class II associated p	8.45E−03	1.36
421944	AA344367	Hs. 109760	Target CAT	5.43E−05	1.36
412288	NM_003005	Hs. 73800	selectin P (granule membrane protein 140	9.21E−03	1.35
445165	AV652831	Hs. 234058	gb: AV652831 GLC Homo sapiens cDNA clone	2.67E−06	1.35
432372	AI659280	Hs. 155004	ESTs	3.61E−05	1.35
421887	AW161450	Hs. 109201	CGI-86 protein	9.93E−06	1.35
418962	AA714835	Hs. 271863	ESTs	1.92E−07	1.35
407885	AA373889	Hs. 41007	mitochondrial ribosomal protein L22	4.57E−07	1.35
443835	AF016371	Hs. 9880	peptidyl prolyl isomerase H (cyclophilin	1.23E−06	1.35
456113	H71616	Hs. 135233	ESTs	2.62E−03	1.35
423878	AI907090	Hs. 52891	hypothetical protein PRO1853	4.29E−05	1.35
434509	AA193565	Hs. 79276	Homo sapiens clone IMAGE: 121558 mRNA seq	2.52E−03	1.35
413129	AF292100	Hs. 104613	RP42 homolog	7.65E−06	1.35
419985	H66373	Hs. 5856	ESTs, Highly similar to bA393J16.3 [H. sa	8.31E−04	1.35
432623	AA557351	Hs. 152448	ESTs, Moderately similar to S14147 multi	7.55E−04	1.35
421489	AI922821	Hs. 32433	ESTs	2.40E−03	1.35
424539	L02911	Hs. 150402	Activin A receptor, type I (ACVR1) (ALK	5.27E−05	1.35
410256	AB037732	Hs. 61441	KIAA1311 protein	1.95E−05	1.35
410365	AI287518		Homo sapiens mRNA; cDNA DKFZp586D0923 (f	1.10E−03	1.35
458439	AV647220	Hs. 106576	alanine-glyoxylate aminotransferase 2-li	1.43E−05	1.35
406137			NM_000179*: Homo sapiens mutS (E. coli) h	1.43E−03	1.35
428466	AF151063	Hs. 184456	hypothetical protein	1.07E−04	1.35
432358	AI093491	Hs. 274413	hypothetical protein FLJ11218	5.55E−04	1.35
416676	AW392022	Hs. 79507	KIAA0582 protein	2.42E−03	1.35
447139	AL134744	Hs. 10852	ESTs	4.56E−08	1.35
436137	AI056769	Hs. 133512	ESTs	9.06E−05	1.35
438459	T49300	Hs. 35304	Homo sapiens cDNA FLJ13655 fis, clone PL	3.65E−05	1.35
424649	BE242035	Hs. 151461	embryonic ectoderm development	9.97E−07	1.35
413806	L12535	Hs. 75551	Ras suppressor protein 1	3.39E−05	1.35
424972	BE247567	Hs. 154045	KIAA0082 protein	8.45E−07	1.35
447387	AI268331	Hs. 102237	tubby super-family protein	1.42E−07	1.34
413858	NM_001610	Hs. 75589	acid phosphatase 2, lysosomal	1.36E−03	1.34
427399	NM_014883	Hs. 177664	KIAA0914 gene product	2.29E−06	1.34
455631	BE063031		gb: MR0-BT0265-231199-002-e09 BT0265 Homo	3.66E−03	1.34
409542	AA503020	Hs. 36563	hypothetical protein FLJ22418	6.76E−03	1.34
429598	AA811257	Hs. 269710	ESTs	8.67E−05	1.34
421166	AA305407	Hs. 102308	potassium inwardly-rectifying channel, s	4.96E−07	1.34
432523	AA551756		ESTs	7.86E−06	1.34
445652	AL117473	Hs. 13036	DKFZP727A071 protein	2.35E−05	1.34
433923	AI823453	Hs. 146625	ESTs	2.49E−05	1.34
420843	H96982	Hs. 42321	ESTs	1.00E−03	1.34
440328	AW392243		endogenous retroviral protease	5.80E−04	1.34
442406	NM_014846	Hs. 8294	KIAA0196 gene product	5.90E−05	1.34
400763			Target Exon	2.50E−03	1.34
440973	AI656743	Hs. 127514	ESTs	9.83E−03	1.34
427674	NM_003528	Hs. 2178	H2B histone family, member Q	1.03E−04	1.34
429837	NM_003896	Hs. 225939	sialyltransferase 9 (CMP-NeuAc: lactosylc	1.21E−04	1.34
452887	AI702223	Hs. 107253	hypothetical protein DKFZp761F241	1.70E−03	1.34
424321	W74048	Hs. 1765	lymphocyte-specific protein tyrosine kin	1.54E−05	1.34
412347	AW970026	Hs. 73818	ubiquinol-cytochrome c reductase hinge p	1.38E−05	1.34
425843	BE313280	Hs. 159627	death associated protein 3	5.79E−05	1.34
412710	AA115819	Hs. 187593	ESTs	1.53E−03	1.34
422607	Z45471	Hs. 118684	stromal cell-derived factor 2	1.25E−06	1.34
441004	AL137488	Hs. 7615	Homo sapiens mRNA; cDNA DKFZp434N2030 (f	1.10E−04	1.34
441229	AW083064		ESTs	8.72E−05	1.33
445718	H79791	Hs. 15227	ESTs	1.85E−06	1.33
426032	H63477	Hs. 81188	ESTs, Moderately similar to ALU1_HUMAN A	7.52E−04	1.33
414080	AA135257	Hs. 47783	B aggressive lymphoma gene	1.15E−04	1.33
407309	AA526438	Hs. 281680	peroxisomal trans 2-enoyl CoA reductase;	9.94E−06	1.33
409977	AW805510	Hs. 97056	hypothetical protein FLJ21634	2.34E−04	1.33
447347	AA570056	Hs. 122730	ESTs, Moderately similar to KIAA1215 pro	1.70E−07	1.33
429682	NM_006306	Hs. 211602	SMC1 (structural maintenance of chromoso	6.55E−03	1.33
428023	AL038843		Homo sapiens cDNA; FLJ23602 fis, clone L	1.70E−03	1.33
412677	AW029608	Hs. 17384	ESTs	1.00E−03	1.33
424967	AI188435		RAB27A, member RAS oncogene family	5.80E−05	1.33
403608			C3001199: gi|7494834|pir||T15308hypothet	1.24E−03	1.33
445292	AV653264	Hs. 13982	Homo sapiens cDNA FLJ14666 fis, clone NT	1.47E−04	1.33
425882	U83115	Hs. 161002	absent in melanoma 1	2.79E−09	1.33
421767	AW390255	Hs. 108112	histone fold protein CHRAC17; DNA polyme	4.64E−05	1.33
439908	AI168031	Hs. 155507	ESTs	1.11E−04	1.33
421282	AA286914	Hs. 40782	ESTs	6.68E−06	1.33
420838	AW118210	Hs. 42321	ESTs	2.32E−04	1.33
453403	BE466639	Hs. 61779	Homo sapiens cDNA FLJ13591 fis, clone PL	4.15E−04	1.33
426343	NM_014642	Hs. 169387	KIAA0036 gene product	1.55E−04	1.33
445592	AV654382	Hs. 17947	ESTs, Weakly similar to T16534 hypotheti	1.22E−05	1.33
446048	AI272364	Hs. 182081	KIAA1811 protein	4.47E−03	1.33
415023	AA932146		Homo sapiens clone TCCCIA00164 mRNA sequ	9.58E−07	1.33
427726	AI359144	Hs. 143688	Homo sapiens cDNA: FLJ23031 fis, clone L	8.02E−07	1.33
417947	AA323563	Hs. 325309	hypothetical protein FLJ14596	2.89E−04	1.33
434260	AF121856	Hs. 284291	sorting nexin 6	2.30E−08	1.33
437306	AW270552		ESTs	1.55E−03	1.32
410125	AK000846	Hs. 58679	solute carrier family 7, (cationic amino	1.60E−04	1.32
451168	D31770	Hs. 26014	activin A receptor, type II	4.12E−03	1.32
416315	AA179483	Hs. 73605	ESTs	1.38E−05	1.32
411784	AK001715	Hs. 72085	hypothetical protein FLJ10853	5.04E−08	1.32
452144	AA032197	Hs. 102558	Homo sapiens, clone MGC: 5352, mRNA, comp	3.29E−05	1.32
426012	AA367507	Hs. 75874	pregnancy-associated plasma protein A	7.29E−03	1.32
425295	AA431366	Hs. 37251	ESTs	4.74E−04	1.32
437986	AA774575	Hs. 121776	testis expressed sequence 11	2.42E−03	1.32
442332	AI693251	Hs. 8248	Target CAT	1.30E−05	1.32
439208	AK000299	Hs. 180952	dynactin 4 (p62)	1.04E−05	1.32
456073	AA587775	Hs. 66295	multi-PDZ-domain-containing protein	3.40E−05	1.32
428738	NM_000380	Hs. 192803	xeroderma pigmentosum, complementation g	1.52E−05	1.32
452479	AI903573		gb: RC-BT031-280199-114 BT031 Homo sapien	5.19E−03	1.32
452548	AL050321	Hs. 301532	CRP2 binding protein	3.09E−06	1.32
450016	AA249590	Hs. 4747	ESTs, Weakly similar to A28996 proline-r	5.01E−06	1.32
431675	AA699965		ESTs	6.72E−04	1.32
430261	AA305127	Hs. 4147	hypothetical protein HT023	4.00E−06	1.32
411885	AA452636	Hs. 131057	ESTs, Moderately similar to CRGD_HUMAN G	2.36E−03	1.32
426857	AW581992	Hs. 301434	KIAA1387 protein	7.58E−04	1.32
407825	NM_006152	Hs. 40202	lymphoid-restricted membrane protein	3.74E−03	1.32
441647	AA534210	Hs. 285280	Homo sapiens cDNA: FLJ22096 fis, clone H	5.30E−04	1.32
409401	AI201895	Hs. 181309	proteasome (prosome, macropain) subunit,	2.42E−05	1.32
437293	AA836401	Hs. 87860	ESTs	1.61E−04	1.32
418780	AA228078	Hs. 255096	ESTs	2.84E−03	1.31
431586	AW971100	Hs. 293189	ESTs	6.50E−04	1.31
438979	AW976218	Hs. 32565	ESTs	2.44E−06	1.31
458207	T28472	Hs. 7655	U2 small nuclear ribonucleoprotein auxil	1.40E−03	1.31
453320	AW450240	Hs. 257274	ESTs	5.85E−03	1.31
426796	S78234	Hs. 172405	cell division cycle 27	1.75E−04	1.31
432600	AI821085		gb: ns95a12.y5 NCl_CGAP_Pr3 Homo sapiens	1.05E−03	1.31
409572	AL048938	Hs. 54971	hypothetical protein	1.72E−08	1.31
408758	NM_003686	Hs. 47504	exonuclease 1	1.43E−04	1.31
445648	AW362302	Hs. 164090	ESTs	4.03E−04	1.31
432987	AI864771	Hs. 27954	CD86 antigen (CD28 antigen ligand 2, B7-	1.27E−06	1.31
419943	AA252111	Hs. 15200	ESTs	9.35E−05	131
413274	NM_004893	Hs. 75258	H2A histone family, member Y	5.15E−04	1.31
449365	AW968261	Hs. 118913	ESTs, Moderately similar to T46371 hypot	4.97E−03	1.31
414411	X54079	Hs. 76067	heat shock 27 kD protein 1	1.14E−06	1.31
400271			NM_004344: Homo sapiens centrin, EF-hand	2.70E−04	1.31
448071	BE621584	Hs. 6983	Homo sapiens cDNA: FLJ22646 fis, clone H	1.50E−05	1.31
450289	AI690295	Hs. 243598	ESTs	6.16E−04	1.31
417089	H52280	Hs. 18612	Homo sapiens cDNA: FLJ21909 fis, clone H	6.27E−10	1.31
418876	AA740616		gb: ny97f11.s1 NCI_CGAP_GCB1 Homo sapiens	2.19E−06	1.31
443199	AJ002030	Hs. 9071	progesterone membrane binding protein	1.42E−06	1.31
411529	AA430348	Hs. 317596	Homo sapiens cDNA FLJ12927 fis, clone NT	7.08E−03	1.31
453407	AW409745	Hs. 32967	Cockayne syndrome 1 (classical)	2.06E−03	1.31
416365	U15131	Hs. 79265	suppression of tumorigenicity 5	4.90E−04	1.31
440188	AK001812	Hs. 7036	N-Acetylglucosamine kinase	9.80E−05	1.31
440779	AI651910	Hs. 128556	ESTs	9.12E−03	1.31
400840			Target Exon	2.57E−05	1.31
431663	NM_016569	Hs. 267182	TBX3-iso protein	9.11E−05	1.31
409052	AW898179	Hs. 50123	zinc finger protein 189	5.93E−05	1.31
446254	BE179829	Hs. 179852	Homo sapiens cDNA FLJ12832 fis, clone NT	9.61E−03	1.31
407177	W88954	Hs. 203709	ESTs	3.43E−03	1.31
417933	X02308	Hs. 82962	thymidylate synthetase	9.19E−06	1.31
418207	C14685	Hs. 34772	ESTs	3.94E−03	1.31
452139	AA099969	Hs. 16331	Homo sapiens cDNA: FLJ21482 fis, clone C	1.07E−07	1.31
446641	AL049229	Hs. 15787	Homo sapiens mRNA; cDNA DKFZp564O1016 (f	2.24E−03	1.31
407890	AK001607	Hs. 41127	hypothetical protein FLJ13220	1.58E−06	1.30
417928	AA209344	Hs. 30177	ESTs	5.53E−06	1.30
446044	H67567	Hs. 13572	calcium modulating ligand	7.83E−09	1.30
431921	N46466	Hs. 58879	ESTs	2.21E−05	1.30
418020	R35510	Hs. 24990	ESTs	7.14E−04	1.30
409619	AK001015	Hs. 55220	BCL2-associated athanogene 2	3.09E−05	1.30
425836	AW955696	Hs. 90960	ESTs	2.22E−06	1.30
444735	BE019923	Hs. 243122	hypothetical protein FLJ13057 similar to	5.41E−04	1.30
436535	AW295687	Hs. 254420	ESTs	1.12E−05	1.30
415910	U20350	Hs. 78913	chemokine (C-X3-C) receptor 1	8.53E−05	1.30
445388	AI925280	Hs. 128777	EST	2.59E−06	1.30
448965	AF092134	Hs. 22679	CGI-24 protein	3.13E−08	1.30
445757	AW449065	Hs. 13264	KIAA0856 protein	7.74E−04	1.30
414783	AW069569		unactive progesterone receptor, 23 kD	8.35E−06	1.30
448244	BE613416	Hs. 336425	Homo sapiens, clone MGC: 17296. mRNA, com	3.74E−06	1.30
423032	AI684746	Hs. 119274	RAS p21 protein activator (GTPase activa	1.31E−04	1.30
437527	AI241019	Hs. 145644	ESTs	3.77E−04	1.30
408063	BE086548	Hs. 42346	calcineurin-binding protein calsarcin-1	3.50E−04	1.30
437065	AL036450	Hs. 103238	ESTs	1.43E−03	1.29
446841	AV660567		gb: AV660567 GLC Homo sapiens cDNA clone	4.29E−04	1.29
418673	NM_005582	Hs. 87205	lymphocyte antigen 64 (mouse) homolog (	4.79E−04	1.29
433671	AW138797	Hs. 132906	19A24 protein	1.26E−03	1.29
420919	M57892	Hs. 100322	carbonic anhydrase VI	6.69E−04	1.29
447094	X65232	Hs. 17364	zinc finger protein 79 (pT7)	2.23E−04	1.29
417437	U52682	Hs. 82132	interferon regulatory factor 4	9.46E−04	1.29
453929	AW190054		gb: xl11d05.x1 NCI_CGAP_Ut4 Homo sapiens	3.94E−03	1.29
417782	T10149	Hs. 4243	hypothetical protein FLJ12650	9.78E−07	1.29
414438	AI879277	Hs. 76136	thioredoxin	7.32E−05	1.29
459436	AA323121		gb: EST25881 Cerebellum II Homo sapiens c	1.90E−04	1.29
424650	AW576156	Hs. 250824	Homo sapiens cDNA: FLJ23435 fis. clone H	1.85E−04	1.29
422843	AA317826	Hs. 188361	gb: EST19817 Retina II Homo sapiens cDNA	1.68E−04	1.29
458389	H70284	Hs. 160152	ESTs, Weakly similar to FPHU alpha-fetop	2.39E−06	1.29
443562	AF118838	Hs. 9599	solute carrier family 25, member 13 (cit	3.94E−04	1.29
452617	H22717	Hs. 7174	hypothetical protein FLJ22759	5.18E−04	1.29
430488	D19589	Hs. 13453	hypothetical protein FLJ14753	2.68E−04	1.29
413568	AA130381	Hs. 180257	ESTs	1.58E−07	1.29
458725	AW970192	Hs. 171942	ras responsive element binding protein 1	2.03E−05	1.29
403827			C4000447*: gi|7705570|ref|NP_038851.1|KI	9.50E−03	1.29
440740	H87832	Hs. 7388	ketch (Drosophila)-like 3	1.23E−05	1.29
410434	AF051152	Hs. 63668	toll-like receptor 2	5.21E−04	1.29
409161	W07662	Hs. 50861	sirtuin (silent mating type information	5.83E−04	1.29
440213	AW246253	Hs. 7043	succinate-CoA ligase, GDP-forming, alpha	1.79E−08	1.29
443316	AI478463	Hs. 18443	aldehyde dehydrogenase 8 family, member	5.31E−05	1.29
436139	AA765786	Hs. 120936	ESTs	5.79E−06	1.29
427224	AL135554		sine oculis homeobox (Drosophila) homolo	2.33E−06	1.29
412520	AA442324	Hs. 795	H2A histone family, member O	1.46E−06	1.29
452303	R27257	Hs. 57734	heat shock 70 kD protein 1B	1.14E−04	1.28
420151	AA255931	Hs. 186704	ESTs	7.07E−06	1.28
443601	AI078554	Hs. 42658	ESTs	1.61E−05	1.28
450305	AA009477	Hs. 17572	ESTs, Weakly similar to A46010 X-linked	2.83E−05	1.28
431255	AA497043	Hs. 115685	ESTs	9.13E−03	1.28
419935	AB020980	Hs. 93832	putative membrane protein	1.02E−06	1.28
429686	AI871613	Hs. 28538	Homo sapiens cDNA: FLJ21086 fis, clone C	3.27E−03	1.28
442484	AF075360		gb: AF075360 Human fetal liver cDNA libra	1.79E−03	1.28
437916	BE566249	Hs. 20999	hypothetical protein FLJ23142	2.64E−03	1.28
451789	AW291532	Hs. 211297	ESTs	9.14E−03	1.28
429529	AA454190	Hs. 24283	ESTs, Moderately similar to reduced expr	1.14E−03	1.28
434658	AI624436	Hs. 310286	ESTs	8.22E−06	1.28
418831	AA488082		gb: ab13e05.s1 Stratagene lung (937210) H	8.61E−04	1.28
429673	AA884407	Hs. 211595	protein tyrosine phosphatase, non-recept	3.23E−03	1.28
414430	AI346201	Hs. 76118	ubiquitin carboxyl-terminal esterase L1	6.36E−03	1.28
448079	R76981		thyroid hormone receptor-associated prot	7.51E−04	1.28
408677	AI279892	Hs. 46801	sorting nexin 14	4.91E−05	1.28
456508	AA502764	Hs. 123469	ESTs, Weakly similar to AF208855 1 BM-01	8.25E−05	1.28
421290	NM_014368	Hs. 103137	LIM homeobox protein 6	3.64E−04	1.28
431829	BE467737	Hs. 146125	ESTs	1.95E−03	1.28
431892	AA521315	Hs. 194424	ESTs	5.86E−03	1.28
425587	AB018332	Hs. 158319	KIAA0789 gene product	1.52E−03	1.28
428248	AI126772	Hs. 40479	ESTs	4.53E−03	1.28
428580	AF118452	Hs. 184945	gastrulation brain homeo box 2	2.37E−03	1.28
447023	AA356764	Hs. 17109	integral membrane protein 2A	2.36E−05	1.28
442287	AW952703	Hs. 8182	synaptic nuclei expressed gene 1b	6.33E−05	1.28
421215	AI868634	Hs. 246358	ESTs, Weakly similar to T32250 hypotheti	2.84E−06	1.28
410383	AA084561	Hs. 151093	hypothetical protein DKFZp434G1415	9.07E−04	1.28
446832	NM_006314	Hs. 16232	connector enhancer of KSR-like (Drosophi	1.67E−03	1.28
453648	W21493	Hs. 28329	hypothetical protein FLJ14005	3.53E−05	1.27
450869	R05747		ESTs, Weakly similar to organic anion tr	4.55E−05	1.27
429722	U48629	Hs. 12731	ESTs	3.48E−03	1.27
427247	AW504221	Hs. 174103	integrin, alpha L (antigen CD11A (p180).	7.71E−03	1.27
415276	U88666	Hs. 78353	SFRS protein kinase 2	2.57E−05	1.27
437406	AL390182		Homo sapiens mRNA full length insert cDN	8.76E−04	1.27
451743	AW074266	Hs. 23071	ESTs	3.36E−06	1.27
429379	NM_014840	Hs. 200598	KIAA0537 gene product	2.54E−03	1.27
409205	AI952884	Hs. 14832	ESTs, Moderately similar to unnamed prot	4.80E−04	1.27
433590	N98410	Hs. 48364	Homo sapiens regulator of G-protein sign	2.79E−07	1.27
411096	U80034	Hs. 68583	mitochondrial intermediate peptidase	5.65E−03	1.27
433658	L03678	Hs. 156110	immunoglobulin kappa constant	1.89E−03	1.27
411202	AW163223	Hs. 315482	ESTs, Weakly similar to I38022 hypotheti	7.62E−06	1.27
437612	AA827715	Hs. 105153	Homo sapiens, clone IMAGE: 3461987, mRNA,	5.16E−03	1.27
450459	AI697193	Hs. 299254	Homo sapiens cDNA: FLJ23597 fis, clone L	1.63E−03	1.27
458172	BE007237		gb: PM0-BN0139-050500-003-g09 BN0139 Homo	6.27E−04	1.27
437543	H16443	Hs. 7117	glutamate receptor, ionotropic, AMPA 1	6.23E−08	1.27
430958	M81829	Hs. 248160	somatostatin receptor 1	6.82E−06	1.27
408196	AL034548	Hs. 43627	SRY (sex determining region Y)-box 22	1.40E−05	1.27
422385	BE549407	Hs. 115823	ribonuclease P, 40 kD subunit	6.73E−05	1.27
449736	R50120	Hs. 25367	ESTs, Weakly similar to ALR H. sapiens	1.37E−03	1.27
414992	D63302		gb: HUM521A10B Clontech human placenta po	4.14E−06	1.27
438847	AA827232	Hs. 245362	ESTs	1.91E−03	1.27
447445	AW169369	Hs. 158936	ESTs	1.04E−03	1.27
452386	R12499	Hs. 20468	ESTs	1.20E−04	1.27
410215	AI694353		ESTs, Weakly similar to AF205600 1 trans	9.81E−03	1.27
411115	AW818453		gb: RC1-ST0278-020300-015-d01 ST0278 Homo	4.06E−03	1.27
445589	AI565993	Hs. 222189	ESTs	5.35E−05	1.27
433689	AI802331	Hs. 98289	ESTs, Weakly similar to I38022 hypotheti	2.84E−03	1.27
449704	AK000733	Hs. 23900	GTPase activating protein	2.01E−05	1.27
407604	AW191962		collagen, type VIII, alpha 2	6.07E−03	1.27
453985	N44545	Hs. 251865	ESTs	3.21E−05	1.27
409652	BE208589	Hs. 55601	host cell factor 2	1.24E−04	1.26
403809			NM_024743*: Homo sapiens hypothetical pro	2.01E−03	1.26
417798	Y09858	Hs. 82577	spindlin-like	1.17E−03	1.26
445813	Z42023	Hs. 106576	alanine-glyoxylate aminotransferase 2-li	5.56E−06	1.26
447769	AW873704	Hs. 320831	Homo sapiens cDNA FLJ14597 fis, clone NT	1.34E−05	1.26
451593	AF151879	Hs. 26706	CGI-121 protein	9.80E−06	1.26
452780	BE171598		ESTs, Weakly similar to I38022 hypotheti	5.91E−07	1.26
438032	BE045624	Hs. 152992	ESTs	2.14E−03	1.26
426925	NM_001196	Hs. 315689	Homo sapiens cDNA: FLJ22373 fis, clone H	5.81E−07	1.26
445870	AW410053	Hs. 13406	syntaxin 18	7.80E−10	1.26
422043	AL133649	Hs. 110953	retinoic acid induced 1	4.15E−04	1.26
403142			NM_002706*: Homo sapiens protein phosphat	8.57E−05	1.26
437109	AW006781	Hs. 5457	hypothetical protein FLJ10738	2.23E−06	1.26
443551	AI654356	Hs. 272792	hypothetical protein FLJ20307	1.53E−06	1.26
439161	Y15164	Hs. 6483	oral-facial-digital syndrome 1	3.38E−04	1.26
411143	AI525989	Hs. 9088	hypothetical protein MGC3200	4.14E−04	1.26
449082	BE387561	Hs. 22981	DKFZP586M1523 protein	2.46E−06	1.26
441700	AA233556	Hs. 126908	hypothetical protein FLJ12994	7.57E−03	1.26
402813			ENSP00000236495*: DJ1024N4.1 (novel Sodiu	4.14E−03	1.26
440043	BE277457	Hs. 30661	hypothetical protein MGC4606	7.22E−05	1.26
427629	AA233210	Hs. 179943	ribosomal protein L11	6.93E−04	1.26
437231	BE303000	Hs. 288929	hypothetical protein FLJ13258 similar to	8.51E−05	1.25
433043	W57554	Hs. 125019	lymphoid nuclear protein (LAF-4) mRNA	1.39E−04	1.25
408088	AW157022	Hs. 343551	hypothetical protein FLJ22584	6.02E−05	1.25
423598	BE247600	Hs. 155538	ESTs	1.11E−03	1.25
452767	AW014195	Hs. 61472	ESTs, Weakly similar to YAE6_YEAST HYPOT	9.61E−06	1.25
459245	BE242623	Hs. 31939	manic fringe (Drosophila) homolog	1.38E−03	1.25
448984	AW751955	Hs. 22753	hypothetical protein FLJ22318	3.98E−04	1.25
409513	AW966728	Hs. 54642	methionine adenosyltransferase II, beta	1.85E−06	1.25
425508	AA991551	Hs. 97013	Homo sapiens, Similar to RIKEN cDNA 2310	4.63E−05	1.25
408348	AW269752	Hs. 249828	ESTs	2.09E−03	1.25
407783	AW996872	Hs. 172028	a disintegrin and metalloproteinase doma	4.38E−04	1.25
451188	AA054214	Hs. 60684	ESTs	7.70E−03	1.25
458311	AF069478		gb: AF069478 Homo sapiens astrocytoma lib	3.91E−04	1.25
439747	AK001148	Hs. 6671	COP9 complex subunit 4	1.38E−05	1.25
422481	AL050163	Hs. 117339	DNAX-activation protein 10	1.87E−03	1.25
417954	AI633943	Hs. 26613	ESTs, Weakly similar to no similarities	1.54E−03	1.25
417831	H16423	Hs. 82685	CD47 antigen (Rh-related antigen, integr	7.34E−07	1.25
411252	AB018549	Hs. 69328	MD-2 protein	1.16E−08	1.25
403538			Target Exon	4.75E−03	1.25
424464	R68537	Hs. 17962	ESTs	9.59E−05	1.25
413533	BE146973		gb: QV4-HT0222-011199-019-e05 HT0222 Homo	6.62E−07	1.25
416959	D28459	Hs. 80612	ubiquitin-conjugating enzyme E2A (RAD6 h	2.81E−05	1.25
445715	AB012958	Hs. 13137	UV radiation resistance associated gene	1.01E−05	1.25
408738	NM_014785	Hs. 47313	KIAA0258 gene product	3.07E−05	1.25
424931	BE244070	Hs. 1845	MHC class 1 region ORF	2.06E−07	1.24
431118	BE264901	Hs. 250502	carbonic anhydrase VIII	4.32E−03	1.24
450196	AW956868	Hs. 24608	DKFZP564D177 protein	1.20E−08	1.24
452537	AW247390	Hs. 77735	hypothetical protein FLJ11618	9.35E−04	1.24
439653	AW021103	Hs. 6631	hypothetical protein FLJ20373	8.13E−04	1.24
407827	BE278431	Hs. 40323	BUB3 (budding uninhibited by benzimidazo	4.90E−05	1.24
457300	AW297436	Hs. 40328	Homo sapiens cDNA: FLJ21663 fis, clone C	2.26E−04	1.24
425575	AB012851	Hs. 158311	Musashi (Drosophila) homolog 1	7.90E−03	1.24
442410	AW996503	Hs. 197680	ESTs	6.94E−03	1.24
402969			ENSP00000217067*: DJ781B1.3 (A novel prot	7.49E−05	1.24
438899	AF085833	Hs. 135624	ESTs	3.90E−03	1.24
416877	BE386266	Hs. 85658	hypothetical protein FLJ23436	1.12E−05	1.24
434664	R98754	Hs. 271119	ESTs	5.52E−03	1.24
423846	AW978332	Hs. 133260	hypothetical protein FLJ20354	5.39E−03	1.24
442952	AI743261	Hs. 131860	ESTs	4.40E−03	1.24
432201	AI538613	Hs. 298241	Transmembrane protease, serine 3	2.00E−04	1.24
439921	AL110209	Hs. 6770	LCAT-like lysophospholipase	4.54E−06	1.24
431183	NM_006855	Hs. 250696	KDEL (Lys-Asp-Glu-leu) endoplasmic retic	2.31E−03	1.24
407705	AB023139	Hs. 37892	KIAA0922 protein	8.97E−06	1.24
406182			Target Exon	3.52E−03	1.24
433394	AI907753	Hs. 93810	cerebral cavernous malformations 1	5.10E−06	1.24
451687	AL041260	Hs. 26837	Homo sapiens mRNA; cDNA DKFZp586K1123 (f	1.55E−04	1.24
456497	AW967956	Hs. 123648	ESTs, Weakly similar to AF108460 1 ubinu	1.58E−04	1.24
408392	U28831	Hs. 44566	KIAA1641 protein	1.52E−03	1.24
446501	AI302616		ESTs	1.06E−04	1.24
456023	R00028	Hs. 274344	gb: ye70a06.s1 Soares fetal liver spleen	8.92E−04	1.24
433215	AB040912	Hs. 191098	hypothetical protein FLJ11598	1.73E−04	1.24
415261	T40928	Hs. 8346	ESTs	4.69E−04	1.24
414408	BE294783	Hs. 279497	hypothetical protein MGC4638	3.34E−04	1.24
407478	L77559		gb: Homo sapiens DGS-B partial mRNA.	6.01E−03	1.24
406364			Target Exon	2.36E−03	1.24
445006	W91903	Hs. 124814	ESTs	1.24E−03	1.24
411821	BE299339	Hs. 72249	three-PDZ containing protein similar to	1.81E−05	1.24
430275	Z11773	Hs. 237786	zinc finger protein 187	1.54E−03	1.24
445932	BE046441	Hs. 333555	Homo sapiens clone 24859 mRNA sequence	1.72E−03	1.24
409324	W76202	Hs. 9280	lipoic acid synthetase	8.62E−04	1.24
450371	R34926		son of sevenless (Drosophila) homolog 1	2.33E−04	1.24
419309	AW574793	Hs. 321687	Homo sapiens. Similar to F-box only prot	8.89E−04	1.24
436343	H08024	Hs. 5148	FLN29 gene product	1.34E−05	1.24
413654	AA331881	Hs. 75454	peroxiredoxin 3	1.24E−04	1.23
420776	W38672	Hs. 184067	ESTs	8.11E−04	1.23
414496	W73853		ESTs	3.85E−04	1.23
434521	NM_002267	Hs. 3886	karyopherin alpha 3 (importin alpha 4)	5.40E−05	1.23
434158	T86534	Hs. 14372	ESTs	6.53E−04	1.23
430367	AW607425	Hs. 239938	hypothetical protein	1.32E−03	1.23
447783	AF054178	Hs. 19561	NM_005001: Homo sapiens NADH dehydrogenas	2.94E−04	1.23
459697	AA406062	Hs. 98002	ESTs	1.09E−03	1.23
434519	AA635727	Hs. 136581	ESTs, Weakly similar to ARNO_HUMAN ARF N	1.26E−04	1.23
449843	R85337	Hs. 24030	solute carrier family 31 (copper transpo	1.12E−05	1.23
457000	NM_006750	Hs. 172278	syntrophin, beta 2 (dystrophin-associate	3.72E−03	1.23
423743	AB023148	Hs. 173373	KIAA0931 protein	1.13E−03	1.23
457231	AI472022	Hs. 301959	proline synthetase co-transcribed (bacte	8.57E−05	1.23
433192	AB040880	Hs. 98968	ESTs	8.41E−05	1.23
444636	T96667	Hs. 17877	ESTs	8.18E−07	1.23
430289	AK001952	Hs. 238039	hypothetical protein FLJ11090	5.85E−03	1.23
459647	R34107	Hs. 321450	pregnancy specific beta-1-glycoprotein 1	1.04E−04	1.23
427729	AB033100	Hs. 300646	KIAA1274 protein (similar to mouse palad	1.97E−03	1.23
414884	R54418	Hs. 183745	hypothetical protein FLJ13456	7.32E−07	1.23
448554	NM_016169	Hs. 21431	suppressor of fused	2.82E−06	1.23
413116	AA127161	Hs. 4783	hypothetical protein FLJ22035	6.43E−05	1.23
453563	AW608906. comp	Hs. 181163	hypothetical protein MGC5629	9.15E−03	1.23
407955	BE536739	Hs. 109909	ESTs	3.61E−04	1.23
405232			NM_015832: Homo sapiens methyl-CpG bindin	2.82E−03	1.23
457634	AA609738	Hs. 16525	ESTs	5.66E−05	1.23
455100	BE160198		gb: QV1-HT0413-010200-059-h03 HT0413 Homo	2.91E−03	1.23
419424	BE041820	Hs. 38516	Homo sapiens, clone MGC: 15887, mRNA, com	4.91E−04	1.23
408770	AW270608	Hs. 170195	bone morphogenetic protein 7 (osteogenic	1.86E−03	1.23
433854	AA610649	Hs. 333239	ESTs	5.52E−05	1.23
440453	AA885523	Hs. 157003	ESTs	6.78E−03	1.23
439452	AA918317	Hs. 57987	B-cell CLL/lymphoma 11B (zinc finger pro	3.39E−03	1.22
403417			C18000266*: gi|7243027|dbj|BAA92561.1|(A	5.34E−03	1.22
452582	AL137407	Hs. 29911	Homo sapiens mRNA; cDNA DKFZp434M232 (fr	4.03E−04	1.22
410043	D30612	Hs. 58167	zinc finger protein 282	1.77E−06	1.22
405257			Target Exon	1.89E−03	1.22
441869	NM_003947	Hs. 8004	huntingtin-associated protein interactin	7.73E−03	1.22
442103	AA333367	Hs. 8088	similar to S. cerevisiae Sec6p and R. no	3.85E−03	1.22
450256	AA286887	Hs. 24724	MFH-amplified sequences with leucine−ric	7.06E−07	1.22
444693	AB002327	Hs. 11711	KIAA0329 gene product	8.55E−05	1.22
429574	BE268321	Hs. 208912	hypothetical protein MGC861	5.48E−03	1.22
436906	H95990	Hs. 181244	major histocompatibility complex, class	7.11E−06	1.22
444476	AF020038	Hs. 11223	isocitrate dehydrogenase 1 (NADP), solub	2.03E−03	1.22
438393	AA351815	Hs. 50740	Homo sapiens cDNA: FLJ22272 fis, clone H	3.30E−08	1.22
422267	AB033044	Hs. 114012	KIAA1218 protein	1.57E−05	1.22
436796	BE515260	Hs. 5320	hypothetical protein	9.92E−05	1.22
431328	AA502999	Hs. 291591	ESTs	1.24E−04	1.22
450273	AW296454	Hs. 24743	hypothetical protein FLJ20171	6.29E−03	1.22
457284	AF102850	Hs. 227933	Alg5, S. cerevisiae, homolog of	3.22E−05	1.22
417767	BE242241	Hs. 82542	acyloxyacyl hydrolase (neutrophil)	1.33E−05	1.22
438010	BE243045	Hs. 5990	tetratricopeptide repeat domain 4	1.84E−06	1.22
408981	AW500797	Hs. 49427	Gem-interacting protein	1.50E−05	1.22
403585			Target Exon	6.89E−05	1.22
433556	W56321	Hs. 111460	calcium/calmodulin-dependent protein kin	2.49E−06	1.22
418077	AA112036	Hs. 83419	KIAA0252 protein	8.72E−05	1.22
411806	AW864547		gb: PM4-SN0016-120500-003-b12 SN0016 Homo	9.46E−04	1.22
452664	AA398859	Hs. 18397	hypothetical protein FLJ23221	1.42E−08	1.22
432458	AI968598	Hs. 78768	malignant cell expression-enhanced gene/	9.31E−07	1.22
453122	AI953717	Hs. 232214	ESTs	3.42E−04	1.22
424914	AA348410	Hs. 119065	ESTs	3.37E−04	1.22
412633	AF001691	Hs. 74304	periplakin	2.95E−04	1.21
451254	AI571016	Hs. 172967	ESTs	6.90E−04	1.21
439136	AA830610	Hs. 209011	ESTs	1.64E−03	1.21
420231	R06866	Hs. 19813	ESTs	4.37E−04	1.21
428720	T90468	Hs. 178154	ESTs	7.33E−04	1.21
452032	BE244005	Hs. 27610	retinoic acid-and interferon-inducible	3.55E−05	1.21
422032	AA476966	Hs. 110857	polymerase (RNA) III (DNA directed) poly	6.42E−03	1.21
430107	AA465293	Hs. 105069	ESTs	2.55E−04	1.21
442202	BE272862	Hs. 106534	hypothetical protein FLJ22625	1.28E−05	1.21
429012	AW629596	Hs. 194726	BCL2-associated athanogene 4	9.71E−05	1.21
432676	AI187366		gb: qf29c01.x1 Soares_testis_NHT Homo sap	2.09E−05	1.21
407946	AA226495	Hs. 154292	ESTs	2.27E−05	1.21
458216	AW024282	Hs. 104938	hypothetical protein MGC15906	5.72E−07	1.21
403832			C4000013*: gi|11427234|ref|XP_009399.1|z	2.50E−03	1.21
448334	AA767011	Hs. 119960	DKFZP727G051 protein	6.83E−03	1.21
437378	AI198823	Hs. 160473	ESTs	7.48E−04	1.21
425604	U94320	Hs. 158330	neuropeptide Y receptor Y5	5.70E−05	1.21
423024	AA593731	Hs. 325823	ESTs, Moderately similar to ALU5_HUMAN A	6.88E−04	1.21
423609	AA328348	Hs. 218289	ESTs	5.96E−04	1.21
439317	AF086127	Hs. 50600	ESTs, Weakly similar to T47156 hypotheti	1.32E−04	1.21
441765	AI474058	Hs. 170514	ESTs	5.09E−03	1.21
425251	Z22521	Hs. 155342	protein kinase C, delta	3.47E−07	1.21
452185	AA076467	Hs. 246218	Homo sapiens cDNA: FLJ21781 fis, clone H	2.31E−03	1.21
433018	AI669760	Hs. 188881	ESTs	4.27E−05	1.21
450622	AI660285	Hs. 58210	ESTs, Highly similar to ITH4_HUMAN INTER	1.13E−04	1.21
453314	R05604	Hs. 19507	ESTs	9.85E−03	1.21
431375	AI767882	Hs. 264347	ESTs	1.96E−05	1.21
435521	W23814	Hs. 6361	mitogen-activated protein kinase kinase	6.96E−07	1.21
422642	AA314041		gb: EST185894 Colon carcinoma (HCC) cell	2.63E−03	1.21
429855	AW385597	Hs. 199630	ESTs, Weakly similar to B34087 hypotheti	8.01E−03	1.21
412141	AI183838	Hs. 48938	hypothetical protein FLJ21802	2.02E−03	1.21
423799	AW026300	Hs. 132906	19A24 protein	6.14E−03	1.21
432377	AA534670		ESTs, Weakly similar to 2004399A chromos	2.76E−03	1.21
450663	H43540	Hs. 25292	ribonuclease HI, large subunit	2.34E−03	1.21
435561	AA351978	Hs. 4943	hepatocellular carcinoma associated prot	9.96E−04	1.21
415660	AI909007	Hs. 78563	ubiquitin-conjugating enzyme E2G 1 (homo	4.03E−04	1.21
432387	BE094222	Hs. 274457	Homo sapiens mRNA; cDNA DKFZp434H2226 (f	1.53E−03	1.21
458443	AV647010	Hs. 27	glycine dehydrogenase (decarboxylating;	9.56E−04	1.21
442281	N34742	Hs. 170065	Homo sapiens cDNA FLJ13492 fis, clone PL	6.38E−06	1.21
428553	AA181641	Hs. 184907	G protein-coupled receptor 1	3.19E−04	1.21
431604	AF175265	Hs. 264190	vacuolar protein sorting 35 (yeast homol	1.69E−05	1.20
458468	AV648170	Hs. 58756	ESTs	8.67E−04	1.20
427546	AA405280	Hs. 36793	hypothetical protein FLJ23188	2.59E−04	1.20
402964			NM_022095*: Homo sapiens hypothetical C2H	1.55E−04	1.20
442818	AK001741	Hs. 8739	hypothetical protein FLJ10879	3.66E−03	1.20
417957	H53497	Hs. 83006	CGI-139 protein	2.93E−06	1.20
445298	AW295700		ESTs	1.03E−03	1.20
437594	AA761431	Hs. 74335	heat shock 90 kD protein 1, beta	1.32E−03	1.20
414704	NM_014757	Hs. 76986	mastermind (Drosophila), homolog of	3.10E−03	1.20
420339	AW968259	Hs. 186647	ESTs	6.90E−06	1.20
436754	AI061288	Hs. 133437	ESTs	3.43E−03	1.20
422798	R92347	Hs. 34574	ESTs, Weakly similar to ALU1_HUMAN ALU S	254E−03	1.20
444059	R69743	Hs. 116774	integrin, alpha 1	9.70E−06	1.20
433032	AI084066	Hs. 20072	myosin regulatory light chain interactin	9.91E−06	1.20
408761	AA057264	Hs. 238936	ESTs, Weakly similar to (defline not ava	3.30E−07	1.20
443791	N64458	Hs. 143345	ESTs	1.29E−05	1.20
434359	AF129536	Hs. 284226	F-box only protein 6	6.18E−06	1.20
413277	H24177	Hs. 75262	cathepsin O	1.91E−07	1.20
445464	AW172389	Hs. 249999	ESTs	1.75E−03	1.20
401060			Target Exon	3.25E−05	1.20
407588	AW969534	Hs. 267905	hypothetical protein FLJ10422	1.12E−06	1.20
415245	N59650	Hs. 27252	ESTs	1.05E−03	1.20
456577	BE246444	Hs. 283685	hypothetical protein FLJ20396	2.94E−03	1.20
456761	D59899	Hs. 127842	CGI-142	8.55E−03	1.20
446868	AV660737		ESTs	6.71E−03	1.20
421506	BE302796	Hs. 105097	thymidine kinase 1, soluble	2.57E−04	1.20
426181	AA371422	Hs. 334371	hypothetical protein MGC13096	6.57E−05	1.20
417177	NM_004458	Hs. 81452	fatty-acid-Coenzyme A ligase, long-chain	1.65E−04	1.20
425199	R97184		gb: yq58f12.r1 Soares fetal liver spleen	6.03E−03	1.20
414709	AA704703	Hs. 77031	Sp2 transcription factor	1.06E−04	1.20
406350			Target Exon	5.04E−03	1.20
418253	AA215539	Hs. 283643	Homo sapiens cDNA FLJ11606 fis, clone HE	1.06E−04	1.20
419367	AW132011	Hs. 118236	Homo sapiens cDNA: FLJ22132 fis, clone H	3.41E−04	1.19
420517	AB011115	Hs. 98507	KIAA0543 protein	1.61E−04	1.19
432441	AW292425	Hs. 163484	ESTs	6.62E−05	1.19
434163	AW974720	Hs. 25206	group XII secreted phospholipase A2	2.63E−03	1.19
408688	AI634522	Hs. 152925	KIAA1268 protein	4.18E−05	1.19
434560	R13052	Hs. 3964	Homo sapiens clone 24877 mRNA sequence	6.15E−03	1.19
420468	NM_006980	Hs. 97996	transcription termination factor, mitoch	5.07E−04	1.19
409646	AW161391	Hs. 709	deoxycytidine kinase	8.94E−05	1.19
431234	AL389985	Hs. 301637	zinc finger protein 258	6.12E−04	1.19
449259	AW452058	Hs. 257519	ESTs	6.09E−05	1.19
420104	U09825	Hs. 1287	zinc finger protein 173	3.24E−08	1.19
436692	AW243158	Hs. 5297	DKFZP564A2416 protein	6.42E−10	1.19
452715	Z21093	Hs. 30352	ribosomal protein S6 kinase, 52 kD, polyp	8.38E−06	1.19
412372	R65998	Hs. 285243	hypothetical protein FLJ22029	8.03E−04	1.19
452007	AA426234	Hs. 34906	ESTs, Weakly similar to T17210 hypotheti	1.59E−07	1.19
437943	NM_016353	Hs. 5943	rec	6.25E−05	1.19
452983	L32140	Hs. 531	afamin	8.93E−06	1.19
422283	AW411307	Hs. 114311	CDC45 (cell division cycle 45, S.cerevis	2.07E−04	1.19
422061	BE178434	Hs. 267995	ESTs, Moderately similar to G02654 ribos	2.33E−03	1.19
439318	AW837046	Hs. 6527	G protein-coupled receptor 56	4.41E−03	1.19
428972	AK001470	Hs. 194692	cysteine desulfurase	5.56E−03	1.19
418384	AW149266	Hs. 25130	Homo sapiens cDNA FLJ14923 fis, clone PL	1.66E−03	1.19
409442	AA310162	Hs. 169248	cytochrome c	8.53E−05	1.19
411299	BE409857	Hs. 69499	hypothetical protein	1.40E−06	1.19
441307	AW071696	Hs. 209065	hypothetical protein FLJ14225	1.90E−06	1.19
421413	AI826128	Hs. 55209	ESTs, Weakly similar to A49364 59 protei	1.64E−04	1.19
418560	AW291332	Hs. 194414	ESTs	9.68E−03	1.19
428873	AI701609	Hs. 98908	ESTs	8.52E−03	1.19
433330	AW207084	Hs. 132816	hypothetical protein MGC14801	1.55E−04	1.19
424212	NM_005814	Hs. 143131	glycoprotein A33 (transmembrane)	2.16E−03	1.19
444445	AA342329	Hs. 115920	Homo sapiens cDNA: FLJ22816 fis, clone K	1.88E−07	1.19
412994	D32257	Hs. 75113	general transcription factor IIIA	1.32E−04	1.19
439077	AW297762	Hs. 255690	ESTs	2.12E−03	1.19
437714	AA766346		ESTs	4.83E−04	1.19
407142	AA412535		gb: zt99b10.s1 Soares_testis_NHT Homo sap	3.74E−04	1.18
407331	AI570416	Hs. 99910	phosphofructokinase, platelet	5.67E−03	1.18
447960	AW954377	Hs. 26412	ring finger protein 26	9.47E−04	1.18
428829	R14050	Hs. 194051	Homo sapiens mRNA; cDNA DKFZp566B213 (fr	1.47E−05	1.18
426888	H41090	Hs. 97373	ESTs	6.98E−06	1.18
418539	AA224753	Hs. 159500	ESTs	1.06E−05	1.18
435037	AA355113	Hs. 35380	x 001 protein	1.26E−07	1.18
416987	D86957	Hs. 80712	KIAA0202 protein	8.14E−05	1.18
428828	AL117508	Hs. 194035	KIAA0737 gene product	2.66E−06	1.18
427433	D82070	Hs. 177972	chromosome 4 open reading frame 6	2.70E−05	1.18
434707	AI378570	Hs. 116397	ESTs	5.75E−04	1.18
445266	BE222118	Hs. 12479	associated molecule with the SH3 domain	3.36E−05	1.18
427792	M63928	Hs. 180841	tumor necrosis factor receptor superfami	4.60E−03	1.18
403056			eukaryotic translation elongation factor	5.76E−04	1.18
415080	X81789	Hs. 77897	splicing factor 3a, subunit 3, 60 kD	4.92E−04	1.18
418473	AA243335	Hs. 309943	nuclear body protein Sp140	2.69E−03	1.18
419270	NM_005232	Hs. 89839	EphA1	2.89E−03	1.18
419856	AK001401	Hs. 93391	hypothetical protein FLJ10539	5.31E−04	1.18
446207	AW968535	Hs. 14328	hypothetical protein FLJ20071	1.49E−05	1.18
416999	AW195747	Hs. 21122	hypothetical protein FLJ11830 similar to	9.52E−06	1.18
415013	R35274	Hs. 24951	ESTs	1.63E−04	1.18
426143	BE379836		proteasome (prosome, macropain) subunit,	3.16E−07	1.18
439815	AA206079	Hs. 6693	hypothetical protein FLJ20420	4.52E−07	1.18
412723	AA648459	Hs. 335951	hypothetical protein AF301222	2.94E−04	1.18
420882	AA830074	Hs. 291915	ESTs	5.89E−03	1.18
434198	AF119849	Hs. 283028	hypothetical protein PRO1598	2.28E−04	1.18
414602	AW630088	Hs. 76550	Homo sapiens mRNA; cDNA DKFZp564B1264 (f	5.33E−06	1.18
425729	L22647	Hs. 159360	prostaglandin E receptor 1 (subtype EP1)	5.73E−03	1.18
420123	W24330	Hs. 5301	hypothetical protein FLJ14936	5.77E−05	1.18
456495	NM_003403	Hs. 97496	YY1 transcription factor	1.59E−05	1.18
440350	AA883475	Hs. 257103	ESTs	5.34E−03	1.18
437374	AL359571	Hs. 44054	ninein (GSK3B interacting protein)	1.17E−06	1.17
424006	AF054815	Hs. 137548	CD84 antigen (leukocyte antigen)	1.93E−04	1.17
444372	AW377983	Hs. 298140	Homo sapiens cDNA: FLJ22502 fis, clone H	2.17E−07	1.17
426523	S68616	Hs. 170222	solute carrier family 9 (sodium/hydrogen	1.42E−05	1.17
410388	AA831460		KIAA0758 protein	2.88E−03	1.17
421660	R17959	Hs. 106529	CGI-65 protein	8.90E−03	1.17
434759	BE279230	Hs. 4113	S-adenosylhomocysteine hydrolase like 1	9.02E−04	1.17
459122	AI002968	Hs. 235402	ESTs, Weakly similar to T26525 hypotheti	1.59E−03	1.17
450850	AA648886	Hs. 151999	ESTs	5.32E−06	1.17
416326	AF186780	Hs. 79219	RalGDS-like gene; KIAA0959 protein	9.26E−03	1.17
450038	AA005159	Hs. 188489	ESTs	3.51E−03	1.17
447315	AI613123	Hs. 342148	ESTs	1.28E−05	1.17
426773	NM_015556	Hs. 172180	KIAA0440 protein	9.85E−03	1.17
443035	Z45822	Hs. 8906	Homo sapiens clone 24889 mRNA sequence	3.24E−06	1.17
420705	A8032251	Hs. 99872	fetal Alzheimer antigen	9.87E−04	1.17
431661	AB037830	Hs. 267150	KIAA1409 protein	7.91E−06	1.17
435314	AA677891	Hs. 272138	ESTs, Weakly similar to ALU1_JHUMAN ALU S	9.44E−04	1.17
439798	AA203345	Hs. 102178	syntaxin 16	6.96E−04	1.17
430629	AA482392	Hs. 275184	ESTs, Weakly similar to ATS1_HUMAN ADAM-	1.78E−03	1.17
450612	AL359946	Hs. 14779	acetyl-CoA synthetase	2.31E−04	1.17
416771	AA868956	Hs. 13794	sorting nexin 5	2.18E−03	1.17
426244	AI064808	Hs. 168289	succinate dehydrogenase complex, subunit	1.87E−05	1.17
451338	AW612322	Hs. 19131	transcription factor Dp-2 (E2F dimerizat	3.41E−05	1.17
443209	AI040125	Hs. 150521	ESTs	1.48E−03	1.17
458455	AV648310	Hs. 213488	ESTs	2.67E−03	1.17
446975	BE246446	Hs. 16695	ubiquitin-activating enzyme E1-like	3.39E−07	1.17
418796	AA228351	Hs. 34060	ESTs	1.16E−04	1.17
453209	AW887701	Hs. 32356	hypothetical protein FLJ20628	1.00E−04	1.17
416240	NM_001981	Hs. 79095	epidermal growth factor receptor pathway	1.15E−06	1.17
449773	R76294	Hs. 302383	ESTs	7.90E−03	1.17
435918	AF263538	Hs. 86232	growth differentiation factor 3	2.72E−03	1.17
448694	AA478756	Hs. 194477	E3 ubiquitin ligase SMURF2	1.00E−05	1.17
445866	H20899	Hs. 13399	Homo sapiens clone 25032 mRNA sequence	1.92E−05	1.17
411122	F00809	Hs. 172004	coactivator-associated arginine methyltr	4.93E−04	1.17
426307	F24978	Hs. 297962	ESTs	1.19E−05	1.17
442107	AI692286		ESTs	7.80E−03	1.17
416133	NM_001683	Hs. 89512	ATPase, Ca transporting, plasma membrane	7.02E−04	1.17
445784	AI253155	Hs. 146065	ESTs	1.22E−04	1.17
427750	AA693991	Hs. 224737	ESTs	1.79E−03	1.16
406341			C5000881*: gi|2661590|emb|CAA15709.1|(AL	5.21E−05	1.16
430006	BE144167	Hs. 321056	hypothetical protein similar to RNA-bind	2.21E−07	1.16
407821	AA346172	Hs. 195614	ESTs	2.93E−04	1.16
452299	AW206330		hypothetical protein FLJ10901	2.86E−03	1.16
457701	AW855466	Hs. 271866	ESTs, Weakly similar to ALU 1_HUMAN ALU S	4.53E−05	1.16
446106	AA377165	Hs. 44833	ESTs	2.32E−05	1.16
415382	AI743539	Hs. 72465	ESTs, Weakly similar to non-lens beta ga	1.22E−03	1.16
426261	AW242243	Hs. 168670	peroxisomal farnesylated protein	1.89E−05	1.16
440248	AA876138		ESTs	8.70E−04	1.16
452600	AI910842	Hs. 103381	ESTs	2.27E−04	1.16
433023	AW864793		thrombospondin 1	6.72E−06	1.16
404694			Target Exon	6.77E−03	1.16
402668			C1003810: gi|3766132|gb|AAC64377.1| (AC00	1.80E−03	1.16
409141	AW341059	Hs. 250664	EST	2.66E−03	1.16
418757	AI864193	Hs. 169728	hypothetical protein FLJ13150	1.50E−03	1.16
431828	AA572994	Hs. 325489	ESTs	3.69E−06	1.16
410086	AI268405	Hs. 13467	hypothetical protein MGC3251	6.24E−06	1.16
435515	N40080	Hs. 6879	DC13 protein	4.50E−04	1.16
458965	AA010319	Hs. 60389	ESTs	1.59E−04	1.16
442127	AW276851	Hs. 8107	Homo sapiens mRNA; cDNA DKFZp586B0918 (f	7.48E−05	1.16
408127	AW957168	Hs. 289064	hypothetical protein FLJ22251	1.95E−07	1.16
446259	AA425204	Hs. 334721	hypothetical protein FLJ13391	1.62E−03	1.16
405296			C7000453: gi|7301410|gb|AAF56536.1| (AE00	4.75E−04	1.16
410184	AW503667	Hs. 59545	ring finger protein 15	3.38E−06	1.16
445893	AI610702	Hs. 202613	ESTs, Weakly similar to TRHY_HUMAN TRICH	6.11E−08	1.16
432599	R99849	Hs. 269434	Homo sapiens cDNA FLJ12206 fis, clone MA	5.84E−05	1.16
417601	NM_014735	Hs. 82292	KIAA0215 gene product	1.84E−05	1.16
443804	AL135352	Hs. 255883	ESTs, Weakly similar to I38022 hypotheti	1.76E−04	1.16
422302	AF018253	Hs. 114676	tumor necrosis factor receptor superfami	3.44E−04	1.16
416215	BE397505	Hs. 79081	protein phospbatase 1, catalytic subunit	4.93E−08	1.16
433037	NM_014158	Hs. 279938	HSPC067 protein	1.44E−06	1.16
449971	AA807346	Hs. 288581	Homo sapiens cDNA FLJ14296 fis, clone PL	4.28E−06	1.16
447313	U92981	Hs. 18081	Homo sapiens clone DT1P1B6 mRNA, CAG rep	1.16E−03	1.16
430661	AC005551	Hs. 130714	Homo sapiens HSPC323 mRNA, partial cds	6.11E−04	1.16
445817	NM_003642	Hs. 13340	histone acetyltransferase 1	3.99E−04	1.16
430665	BE350122	Hs. 157367	ESTs, Weakly similar to I78885 serine/th	8.58E−06	1.16
428019	W85913	Hs. 30827	insulin receptor substrate 3-like	8.44E−03	1.16
440351	AF030933	Hs. 7179	RAD1 (S. pombe) homolog	3.92E−05	1.15
426455	AK002196	Hs. 264076	Homo sapiens cDNA FLJ11334 fis, clone PL	1.58E−03	1.15
448905	BE242730	Hs. 79093	EBNA-2 co-activator (100 kD)	3.95E−03	1.15
429966	BE081342	Hs. 283037	HSPC039 protein	2.93E−04	1.15
450353	AI244661	Hs. 103296	ESTs, Weakly similar to S65657 alpha-1C-	3.41E−04	1.15
432650	D00860	Hs. 56	phosphoribosyl pyrophosphale synthetase	4.23E−07	1.15
453085	AW954243		KIAA0251 protein	1.99E−03	1.15
407832	AW976516	Hs. 283707	Homo sapiens cDNA: FLJ21354 fis, clone C	7.53E−04	1.15
442159	AW163390	Hs. 278554	heterochromatin-like protein 1	1.35E−05	1.15
444635	Al184268	Hs. 339665	ESTs	2.17E−03	1.15
432541	AW131368		ESTs	9.15E−04	1.15
414134	X60188	Hs. 861	mitogen-activated protein kinase 3	4.95E−04	1.15
437644	AA748575	Hs. 136748	lectin-like NK cell receptor	2.69E−06	1.15
409193	AA131483		gb: zo08e05.r1 Stratagene neuroepithelium	4.60E−03	1.15
422451	AA310753	Hs. 42491	ESTs, Weakly similar to S65657 alpha-1C-	2.28E−04	1.15
402729			Target Exon	7.41E−05	1.15
447505	AL049266	Hs. 18724	Homo sapiens mRNA; cDNA DKFZp564F093 (fr	1.57E−04	1.15
458140	BE268806		gb: 601139917F1 NIH_MGC_8 Homo sapiens cD	2.74E−05	1.15
424670	W61215	Hs. 116651	epithelial V-like antigen 1	2.25E−06	1.15
405122			NM_006798*: Homo sapiens UDP glycosyltran	6.77E−06	1.15
416022	R44729	Hs. 21286	ESTs	6.32E−04	1.15
421772	Z24958	Hs. 108139	zinc finger protein 212	2.77E−07	1.15
422965	H90576	Hs. 28113	ESTs	1.18E−03	1.15
430464	BE393070	Hs. 188541	ESTs	2.44E−03	1.15
416710	AI268325	Hs. 54890	hypothetical protein FLJ23590	2.20E−03	1.15
448366	AI970841	Hs. 271269	ESTs	2.44E−03	1.15
428464	BE615473	Hs. 184447	sirtuin (silent mating type information	9.06E−04	1.15
427879	AA435939	Hs. 98186	chromosome 21 open reading frame 22	2.46E−04	1.15
417226	AW505054	Hs. 4283	ESTs	3.24E−04	1.15
447757	AA071276	Hs. 19469	KIAA0859 protein	7.22E−04	1.15
407575	W27235	Hs. 64311	a disintegrin and metalloproteinase doma	4.80E−04	1.15
446064	AV656376	Hs. 282851	ESTs, Weakly similar to I38022 hypotheti	1.02E−03	115
425372	NM_14663	Hs. 155983	KIAA0677 gene product	4.28E−04	1.15
402737			Target Exon	4.79E−04	1.15
428107	AA421443	Hs. 104835	ESTs	2.00E−04	1.15
434667	D61329	Hs. 32196	mitochondrial ribosomal protein L36	3.49E−06	1.15
423067	AA321355	Hs. 285401	colony stimulating factor 2 receptor, be	2.94E−03	1.15
445208	AI216103		ESTs	1.56E−03	1.15
439581	AI539852	Hs. 118738	KIAA0800 gene product	6.14E−03	1.15
446012	AV656098	Hs. 172382	betainE-homocysteine methyltransferase 2	1.27E−04	1.15
437234	AI472213	Hs. 247711	hypothetical protein FLJ20557	6.90E−03	1.15
408203	AA053137	Hs. 42390	nasopharyngeal carcinoma susceptibility	6.04E−05	1.15
456352	AA233094	Hs. 191517	ESTs	3.71E−03	1.15
422497	D29642	Hs. 1528	KIAA0053 gene product	9.72E−05	1.15
414762	AW068349	Hs. 77257	KIAA0068 protein	9.50E−05	1.15
458799	AI688547		ESTs	3.89E−03	1.15
434271	AA897778	Hs. 201677	ESTs, Weakly similar to Z257_HUMAN ZINC	6.94E−03	1.15
410423	AW402432	Hs. 63489	protein tyrosine phosphatase, non-recept	4.56E−04	1.15
434421	AI915927	Hs. 34771	ESTs	2.00E−04	1.14
423623	AB011117	Hs. 129943	KIAA0545 protein	1.39E−09	1.14
404231			Target Exon	2.75E−03	1.14
423717	AA330036	Hs. 152003	ESTs	8.79E−03	1.14
453370	AI470523	Hs. 139336	ATP-binding cassette, sub-family C (CFTR	6.17E−05	1.14
420820	W26096		Homo sapiens, clone IMAGE: 4179482, mRNA	1.41E−09	1.14
448959	AI610343	Hs. 293267	ESTs	2.10E−04	1.14
423582	BE000831	Hs. 23837	Homo sapiens cDNA FLJ11812 fis, clone HE	6.93E−03	1.14
428310	AF100749	Hs. 183655	sec22 homolog	5.55E−06	1.14
405287			Target Exon	7.91E−04	1.14
426532	AA486725		hypothetical protein FLJ20489	7.45E−04	1.14
423494	AW504365	Hs. 24143	Wiskott-Aldrich syndrome protein interac	1.50E−03	1.14
446161	AA628206	Hs. 14125	p53 regulated PA26 nuclear protein	1.05E−06	1.14
433481	AL040235	Hs. 3346	hypothetical protein FLJ11280	3.23E−03	1.14
434072	H70854		Homo sapiens PRO1082 mRNA, complete cds	7.75E−04	1.14
427691	AW194426	Hs. 20726	ESTs	3.63E−04	1.14
437825	AA769123	Hs. 291947	ESTs	9.72E−04	1.14
430255	AK000703	Hs. 323822	Homo sapiens mRNA for KIAA1551 protein,	3.00E−04	1.14
414872	U82010	Hs. 77513	COX10 (yeast) homolog. cytochrome c oxid	4.26E−03	1.14
439741	BE379646	Hs. 6904	Homo sapiens mRNA full length insert cDN	7.07E−06	1.14
417025	AA262170	Hs. 80917	adaptor-related protein complex 3, sigma	4.41E−05	1.14
418917	X02994	Hs. 1217	adenosine deaminase	2.96E−03	1.14
426367	AW611704	Hs. 48578	ESTs	7.75E−03	1.14
423855	AA331761	Hs. 254859	ESTs	5.33E−05	1.14
450832	AW970602	Hs. 105421	ESTs	4.74E−04	1.14
449028	BE616023	Hs. 25298	KIAA1813 protein	5.52E−04	1.14
426384	AI472078	Hs. 303662	hypothetical protein FLJ13189 (FLJ13189)	1.75E−03	1.14
429652	AA766810	Hs. 259290	ESTs	6.17E−03	1.14
415205	H71616	Hs. 135233	ESTs	5.85E−06	1.14
436860	H12751	Hs. 5327	PRO1914 protein	1.93E−06	1.14
427973	AW851123	Hs. 98286	gb: IL3-CT0220-150200-070-H02 CT0220 Homo	1.93E−03	1.14 ,
426940	AA393537	Hs. 98347	ESTs, Weakly similar to JC5308 testis-sp	2.52E−03	1.14
455588	AI129903	Hs. 74669	vesicle-associated membrane protein 5 (m	4.99E−06	1.14
422532	AL008726	Hs. 118126	protective protein for beta-galactosidas	1.22E−03	1.14
431316	AA502663	Hs. 145037	ESTs	1.70E−04	1.14
408329	AF155510	Hs. 44227	heparanase	7.40E−03	1.14
457415	AK000010	Hs. 258798	hypothetical protein FLJ20003	9.74E−04	1.14
409509	AL036923	Hs. 322710	ESTs	8.97E−03	1.14
414713	BE465243	Hs. 12664	ESTs	8.42E−03	1.13
422567	AF111178	Hs. 118407	glypican 6	4.15E−08	1.13
457346	AI734178	Hs. 93379	ESTs, Highly similar to 1207289A reverse	7.22E−03	1.13
449559	AW614016	Hs. 282131	ESTs	8.76E−05	1.13
447932	AA837474	Hs. 20021	vesicle-associated membrane protein 1 (s	3.47E−06	1.13
434981	AW182577	Hs. 293077	ESTs	1.26E−03	1.13
452186	M120761	Hs. 28307	WW domain binding protein 4 (formin bind	6.11E−03	1.13
442161	AI733230	Hs. 128805	ESTs	6.46E−04	1.13
438580	AA811262	Hs. 299202	ESTs	6.12E−04	1.13
424941	AA128376	Hs. 153884	ATP binding protein associated with cell	7.86E−06	1.13
424867	AI024860	Hs. 153591	Not56 (D. melanogaster)-like protein	1.15E−04	1.13
455063	AW854160		gb: RC3-CT0254-060400-029-f09 CT0254 Homo	4.21E−04	1.13
431874	AW610031	Hs. 323914	translocase of inner milochondrial membr	6.87E−04	1.13
405695			Target Exon	5.77E−03	1.13
424065	NM_016388	Hs. 138701	T-cell receptor interacting molecule	9.24E−05	1.13
441192	AA526626	Hs. 7736	mitochondrial ribosomal protein L27	3.59E−05	1.13
450316	W84446	Hs. 226434	hypothetical protein M6C4643	5.68E−05	1.13
456859	X92521	Hs. 154057	matrix metalloproteinase 19	3.33E−03	1.13
421639	NM_012082	Hs. 106309	Friend of GATA2	5.03E−03	1.13
427844	AV658308	Hs. 2210	thyroid hormone receptor interactor 3	4.55E−05	1.13
412019	AA485890	Hs. 69330	Homo sapiens cDNA FLJ13835 fis. clone TH	4.85E−06	1.13
441892	AB028981	Hs. 8021	KIAA1058 protein	7.83E−06	1.13
416033	NM_012201	Hs. 78979	Golgi apparatus protein 1	1.08E−04	1.13
450455	AL117424	Hs. 25035	chloride intracellular channel 4	3.45E−05	1.13
406658	AI920965	Hs. 77961	major histocompatibility complex, class	3.18E−05	1.13
406827	AA971409		gb: op92c04.s1 NCI_CGAP_Lu5 Homo sapiens	2.85E−05	1.13
457065	AI476318	Hs. 192480	ESTs	4.47E−03	1.13
425538	BE270918	Hs. 164026	Homo sapiens, clone IMAGE: 3534875, mRNA,	1.63E−03	1.13
416852	AF283776	Hs. 80285	Homo sapiens mRNA; cDNA DKFZp586C1723 (f	4.61E−04	1.13
422929	AA356694	Hs. 94011	ESTs, Weakly similar to MGB4_HUMAN MELAN	1.74E−04	1.13
435274	AA887547	Hs. 150905	ESTs	7.03E−06	1.13
415825	Y18024	Hs. 78877	inositol 1,4,5-trisphosphate 3-kinase B	6.01E−04	1.13
416957	U86749	Hs. 80598	transcription elongation factor A (Sll),	4.33E−06	1.13
420721	AA927802	Hs. 159471	ZAP3 protein	3.70E−03	1.13
421313	NM_014923	Hs. 103329	KIAA0970 protein	1.14E−04	1.13
420885	NM_005652	Hs. 100030	telomeric repeat binding factor 2	1.65E−05	1.13
437156	AI916600	Hs. 121194	Homo sapiens cDNA: FLJ21569 fis, clone C	1.03E−03	1.13
436614	AW104388	Hs. 149091	ESTs	6.83E−03	1.13
451591	AA886446	Hs. 23590	solute carrier family 16 (monocarboxylic	5.25E−04	1.13
445977	BE550048	Hs. 145735	ESTs	7.77E−05	1.13
401112			NM_024997*: Homo sapiens hypothetical pro	2.93E−03	1.13
418096	AA282660	Hs. 193520	ESTs	3.07E−03	1.13
410247	AF181721	Hs. 61345	RU2S	2.71E−03	1.13
407754	AA527348	Hs. 288967	Homo sapiens cDNA FLJ14105 fis, clone MA	2.18E−03	1.13
403671			C4001270*: gi|7509005|pir||T26190 hypothe	2.04E−04	1.13
448294	AI479918	Hs. 192859	ESTs	5.40E−04	1.13
414726	BE466863	Hs. 280099	ESTs	1.35E−04	1.13
422489	AA311216	Hs. 183953	ESTs	3.48E−03	1.13
429595	AI910584	Hs. 127639	ESTs	9.52E−04	1.13
419854	AW664873	Hs. 87836	Homo sapiens PAC clone RP5-1087M19 from	1.17E−05	1.12
418522	AA605038	Hs. 7149	Homo sapiens cDNA: FLJ21950 (is, clone H	2.05E−05	1.12
452717	AW160399	Hs. 30376	hypothetical protein	9.03E−04	1.12
445495	BE622641	Hs. 38489	ESTs, Weakly similar to I38022 hypotheti	6.31E−05	1.12
438724	AW612553	Hs. 114670	Human DNA sequence from clone RP11-16L21	7.89E−08	1.12
426110	NM_002913	Hs. 166563	replication factor C (activator 1) 1 (14	5.22E−09	1.12
416411	AA180188	Hs. 10706	ADP-ribosylation factor-like 4	1.05E−04	1.12
422614	AI908006	Hs. 295362	Homo sapiens cDNA FLJ14459 fis, clone HE	5.79E−04	1.12
438650	AA843728	Hs. 123533	ESTs	5.65E−03	1.12
437175	AW968078	Hs. 87773	protein kinase, cAMP-dependent, catalyti	2.02E−O6	1.12
445278	BE391904	Hs. 12482	glyceronephosphate O-acyltransferase	1.81E−03	1.12
424577	AI346124	Hs. 28813	ESTs, Weakly similar to A23772 UNE-1 hy	1.80E−03	1.12
410575	BE207480	Hs. 6994	Homo sapiens cDNA: FLJ22044 fis, clone H	2.56E−06	1.12
424779	AL046851	Hs. 153053	CD37 antigen	7.40E−03	1.12
452057	AW952005	Hs. 14928	hypothetical protein FLJ12903	2.36E−04	1.12
427008	Z45258	Hs. 286013	short coiled-coil protein	2.52E−06	1.12
417944	AU077196	Hs. 82985	collagen, type V, alpha 2	6.04E−05	1.12
443260	AW896265	Hs. 127310	ESTs, Weakly similar to 1805352A splicin	3.66E−05	1.12
420152	AW968080	Hs. 171553	Homo sapiens clone 24630 mRNA sequence	2.74E−05	1.12
430050	AA430993	Hs. 227913	APIS-like 1	6.41E−04	1.12
425302	U79115	Hs. 155566	CASP2 and RIPK1 domain containing adapto	9.39E−05	1.12
411988	AA455459	Hs. 164480	ESTs, Weakly similar to T50609 hypotheti	3.48E−05	1.12
406657	AI678644	Hs. 277477	major histocompatibility complex, class	2.78E−05	1.12
421940	AA311445	Hs. 9052	Homo sapiens cDNA: FLJ22042 fis, clone H	1.17E−05	1.12
458812	W57902	Hs. 90744	proteasome (prosome, macropain) 26S subu	2.72E−06	1.12
409008	AA059392	Hs. 66791	ESTs	2.07E−04	1.12
410700	AA352335	Hs. 65641	hypothetical protein FLJ 20073	4.95E−04	1.12
458229	AI929602	Hs. 177	phosphatidylinositol glycan, class H	6.18E−03	1.12
400886			Target Exon	4.47E−04	1.12
422993	AF154415	Hs. 122843	CASP8 associated protein 2	1.49E−03	1.12
452501	AB037791	Hs. 29716	hypothetical protein FLJ 10980	1.47E−03	1.12
443202	AW843882	Hs. 19669	ESTs, Weakly similar to T17346 hypotheti	8.03E−04	1.12
402474			NM_004079: Homo sapiens cathepsin S (CTSS	7.68E−07	1.12
440993	A1274880	Hs146339	ESTs	6.87E−03	1.12
400157			Eos Control	5.48E−05	1.12
449209	BE616830	Hs. 294145	ESTs	5.38E−07	1.12
446771	AA128965	Hs. 60679	TATA box binding protein (TBP)-associate	6.52E−07	1.12
433533	D53304	Hs. 9028	fusion, derived from t(12;16) malignant	1.09E−04	1.12
430799	C19035	Hs. 164259	ESTs	6.28E−04	1.12
453870	AW385001	Hs. 8042	Homo sapiens cDNA: FLJ23173 fis, clone L	1.66E−03	1.12
421748	NM_014718	Hs. 107809	KIAA0726 gene product	8.58E−05	1.11
414181	AK000476	Hs. 75798	hypothetical protein	5.55E−06	1.11
409327	L41162	Hs. 53563	collagen, type IX, alpha 3	2.49E−05	1.11
407804	AF228603	Hs. 39957	pleckstrin 2 (mouse) homolog	2.09E−03	1.11
434821	AA159111	Hs. 284281	Human putative ribosomal protein S1 mRNA	2.44E−07	1.11
411887	AW182924	Hs. 128790	ESTs	4.06E−03	1.11
414515	AA947457	Hs. 135560	ESTs, Weakly similar to T43458 hypotheti	8.13E−03	1.11
440706	AA927562	Hs. 148234	ESTs	2.22E−03	1.11
424928	AW753193	Hs. 188361	Homo sapiens cDNA FLJ12807 fis, clone NT	1.01E−03	1.11
410342	R31350	Hs. 743	Fc fragment of IgE, high affinity I, rec	7.13E−03	1.11
449261	AI637592		ESTs	5.50E−03	1.11
448391	H71025	Hs. 21075	GTF2I repeat domain-containing 1	4.49E−06	1.11
419384	AA490866	Hs. 39429	ESTs	9.16E−04	1.11
414256	AW410035	Hs. 75862	MAD (mothers against decapentaplegic, Dr	3.56E−04	1.11
451652	AA018968	Hs. 133536	ESTs	2.21E−05	1.11
430235	BE268048	Hs. 236494	RAB10, member RAS oncogene family	2.93E−06	1.11
452694	AK001736	Hs. 30318	hypothetical protein FLJ10874	9.45E−03	1.11
444377	AA134369	Hs. 11042	hypothetical protein	5.02E−07	1.11
420309	AW043637	Hs. 21766	ESTs, Weakly similar to ALU5_HUMAN ALU S	1.91E−04	1.11
436845	AA732297	Hs. 113928	ESTs	2.01E−03	1.11
443530	BE563088	Hs. 9552	binder of Arl Two	1.45E−04	1.11
414618	AI204600	Hs. 96978	hypothetical protein MGC10764	8.68E−04	1.11
434636	AA083764		hypothetical protein MGC3178	4.36E−04	1.11
422001	AW891476	Hs. 122764	BRCA1 associated protein	2.23E−03	1.11
413186	AU077141		solute carrier family 16 (monocarboxylic	2.27E−04	1.11
423692	BE621056	Hs. 131731	hypothetical protein FLJ11099	1.29E−03	1.11
417890	R79048		gb: yi87gO2.r1 Soares placenta Nb2HP Homo	3.79E−03	1.11
453823	AL137967		gb: DKFZp761D2315_r1 761 (synonym: hamy2)	8.96E−03	1.11
431976	AA719001	Hs. 291065	ESTs	3.97E−06	1.11
421183	AL135740	Hs. 102447	TSC-22-like	1.31E−04	1.11
417382	AI818489	Hs. 139709	hypothetical protein FLJ12572	6.22E−03	1.11
436643	AA757626	Hs. 10941	ESTs, Weakly similar to IPP1_HUMAN PROTE	6.13E−06	1.11
436763	AI168278		ESTs	9.15E−03	1.11
422426	W79117	Hs. 58559	ESTs	7.92E−03	1.11
418018	AW973655	Hs. 286184	hypothetical protein dJ551D2.5	8.85E−03	1.11
425145	BE242802	Hs. 154797	KIAA0090 protein	4.53E−04	1.11
435313	AI769400	Hs. 189729	ESTs	3.81E−03	1.11
421305	BE397354	Hs. 324830	diptheria toxin resistance protein requi	5.71E−03	1.11
427939	T92459	Hs. 16886	ESTs	1.26E−03	1.11
433365	AF026944	Hs. 293797	ESTs	1.03E−04	1.11
458524	N63262	Hs. 135965	ESTs	1.76E−03	1.11
419590	AFO05043	Hs. 91390	poly (ADP-ribose) glycohydrolase	4.96E−06	1.11
418224	AL036057	Hs. 83795	interferon regulatory lactor 2	3.93E−05	1.10
429272	W25140	Hs. 110667	ESTs	3.57E−03	1.10
452586	AW958479	Hs. 289043	spindlin	9.58E−05	1.10
438363	AI886351	Hs. 22353	hypothetical protein FLJ21952	8.36E−06	1.10
437042	AK000702	Hs. 5420	hypothetical protein FLJ20695	3.05E−03	1.10
457130	NM_005651	Hs. 183671	tryptophan 2,3-dioxygenase	9.64E−06	1.10
456651	AA302420	Hs. 163622	ESTs	1.91E−03	1.10
446002	AI346468		ESTs	1.53E−04	1.10
441389	AF134838	Hs. 7835	endocytic receptor (macrophage mannose r	3.16E−03	1.10
442524	H45879	Hs. 37288	nuclear receptor subfamily 1, group D, m	1.56E−04	1.10
437888	AA373314	Hs. 5897	Homo sapiens mRNA; cDNA DKFZp586P1622 (f	1.82E−08	1.10
448822	BE149845	Hs. 289038	hypothetical protein MGC4126	2.67E−04	1.10
409835	AW501362		gb: UI-HF-BP0p-aiv-a-08-0-Ul.r1 NIH_MGC_5	2.67E−04	1.10
420181	AI380089	Hs. 158951	ESTs	6.82E−04	1.10
457650	AA649162	Hs. 236456	ESTs	3.31E−09	1.10
409717	AW452871	Hs. 56043	CGI-115 protein	3.69E−03	1.10
408831	AF090114	Hs. 48433	endocrine regulator	5.13E−05	1.10
420131	F08286	Hs. 95262	nuclear factor related to kappa B bindin	2.43E−05	1.10
427468	AB036829	Hs. 178347	SKIP for skeletal muscle and kidney enri	3.88E−04	1.10
442990	AA197226	Hs. 19347	hypothetical protein MGC11321	1.85E−04	1.10
420867	NM_014183	Hs. 100002	HSPC162 protein	1.64E−08	1.10
450401	AW959281	Hs. 8184	ESTs	4.53E−04	1.10
453259	R93125	Hs. 124187	ESTs	4.73E−03	1.10
448384	R12314	Hs. 21056	Homo sapiens cDNA: FLJ21366 fis, clone C	1.32E−04	1.10
446141	AW631255	Hs. 324470	L-3-hydroxyacyl-Coenzyme A dehydrogenase	4.46E−04	1.10
428746	AW503820	Hs. 192861	Spi-B transcription factor (Spi-1/PU.1 r	1.56E−03	1.10
435523	T62849	Hs. 11090	membrane-spanning 4-domains, subfamily A	3.95E−06	1.10
418816	T29621	Hs. 88778	carbonyl reductase 1	2.36E−08	1.10
450222	U75308	Hs. 24644	TATA box binding protein (TBP)-associate	3.72E−04	1.10
408633	AW963372	Hs. 46677	PRO2000 protein	8.12E−04	1.10
439898	AW505514	Hs. 209561	KIAA1715 protein	3.80E−04	1.10
411111	AW818127		gb: CM1-ST0277-061299-059-b07 ST0277 Homo	5.18E−04	1.10
435010	N89307	Hs. 124696	oxidoreductase UCPA	2.08E−07	1.10
434039	L32977	Hs. 3712	ubiquinol-cytochrome c reductase, Rieske	4.10E−04	1.10
417094	NM_006895	Hs. 81182	histamine N-methyltransferase	4.50E−07	1.10
408655	AJ243950	Hs. 46735	deafness locus associated putative guani	1.30E−04	1.10
421968	W22587	Hs. 110095	Homo sapiens mRNA; cDNA DKFZp761E0711(f	3.52E−03	1.10
427172	AA398844	Hs. 64595	ESTs, Weakly similar to AF151831 1 CGI-7	2.07E−06	1.10
426059	BE292842	Hs. 166120	interferon regulatory factor 7	4.26E−06	1.10
408047	AW205461	Hs. 243612	ESTs	5.99E−05	1.10
446616	R65964	Hs. 334873	ESTs, Weakly similar to ALU8_HUMAN ALU S	1.80E−03	1.10
423252	AB005289	Hs. 125856	ATP-binding cassette, sub-family B (MDR/	5.53E−03	1.09
437869	W91976	Hs. 290834	ESTs	2.89E−05	1.09
412577	Z22968	Hs. 74076	CD163 antigen	8.49E−06	1.09
420664	AI681270	Hs. 99824	BCE-1 protein	1.33E−06	1.09
432891	AF161483	Hs. 279761	HSPC134 protein	9.54E−03	1.09
448346	AW515030	Hs. 258526	ESTs	1.07E−04	1.09
408594	BE144666		gb: CM2-HT0176-041099-017-c02 HT0176 Homo	4.37E−05	1.09
437730	AW071087	Hs. 239176	insulin-like growth factor 1 receptor	3.49E−03	1.09
414966	BE544579	Hs. 77690	RAB5B, member RAS oncogene family	8.08E−03	1.09
422722	H74219	Hs. 269772	ESTs	1.24E−03	1.09
446392	AF142419	Hs. 15020	homolog of mouse quaking QKI (KH domain	8.53E−05	1.09
405064			Target Exon	4.07E−03	1.09
453555	N23574	Hs. 123649	ESTs, Moderately similar to ALU7_HUMAN A	3.02E−06	1.09
448928	AI350260	Hs. 301539	mitochondrial ribosomal protein L34	2.32E−03	1.09
421643	BE281170	Hs. 106357	valosin-containing protein	8.84E−06	1.09
436749	AA584890	Hs. 5302	leclin, galactoside-binding, soluble, 4	9.82E−04	1.09
449223	AB002348	Hs. 23263	KIAA0350 protein	3.59E−05	1.09
446927	AW503484	Hs. 16533	myosin phosphatase, target subunit 1	1.36E−03	1.09
439616	BE018635	Hs. 58582	Homo sapiens cDNA FLJ12789 fis, clone NT	4.53E−06	1.09
433361	AW469373		ribosomal protein L39	6.62E−03	1.09
410781	AI375672	Hs. 165028	ESTs	4.93E−05	1.09
421535	AB002359	Hs. 105478	phosphoribosylformylglycinamidine syntha	6.66E−04	1.09
442079	AW183787		ESTs	2.49E−03	1.09
443274	BE540891		protein kinase, cAMP-dependent, regulato	3.02E−04	1.09
437070	AA765471	Hs. 154494	ESTs, Weakly similar to 2109260A B cell	4.49E−03	1.09
424690	BE538356	Hs. 151777	eukaryotic translation initiation factor	1.30E−05	1.09
418510	R94322	Hs. 271642	ESTs, Weakly similar to I38022 hypotheti	2.87E−03	1.09
422773	AB028962	Hs. 301552	KIAA1039 protein	1.54E−03	1.09
436907	AA737171	Hs. 131809	ESTs	1.38E−05	1.09
420087	AI653368	Hs. 81889	ESTs	2.56E−03	1.09
426407	BE272112	Hs. 48563	ESTs, Moderately similar to ALU2_HUMAN A	3.11E−04	1.09
425917	W28517	Hs. 117167	Homo sapiens cONA: FLJ23067 fis, clone L	5.77E−08	1.09
417973	NM_004490	Hs. 83070	growth factor receptor-bound protein 14	2.92E−03	1.09
444026	AA205759	Hs. 10119	hypothetical protein FLJ14957	1.40E−06	1.09
413840	AI301558		RNA binding motif protein, X chromosome	1.30E−04	1.09
451612	AI928962	Hs. 26761	DKFZP586L0724 protein	3.91E−05	1.09
414839	X63692	Hs. 77462	DNA (cytosine-5-)-methyltransferase 1	1.24E−03	1.09
438827	AI288188	Hs. 32124	ESTs, Moderately similar to ALU1 _HUMAN A	9.62E−06	1.09
438897	R52285	Hs. 289018	Homo sapiens cDNA: FLJ22918 fis, clone K	2.03E−03	1.08
427547	BE047653	Hs. 119183	ESTs, Weakly similar to ZN91_HUMAN ZINC	4.93E−04	1.08
439205	AF087990	Hs. 42758	Homo sapiens, clone IMAGE: 3354845, mRNA,	4.77E−03	1.08
427095	AA316080	Hs. 173554	ubiquinol-cytochrome c reductase core pr	4.13E−06	1.08
425154	NM_001851	Hs. 154850	collagen, type IX, alpha 1	1.08E−03	1.08
426466	BE619053	Hs. 170001	eukaryotic translation initiation factor	2.34E−04	1.08
413580	T64632	Hs. 202974	ESTs, Weakly similar to B57785 zinc fing	1.99E−03	1.08
443084	AI827639	Hs. 125539	ESTs	1.18E−03	1.08
434724	AA644555	Hs. 136568	ESTs	3.11E−03	1.08
429292	AW161453	Hs. 198767	COP9 (constitutive photomorphogenic, Ara	2.29E−09	1.08
423120	AW160551	Hs. 124021	soggy-1 gene	1.53E−03	1.08
433350	BE563152	Hs. 10362	Homo sapiens cDNA: FLJ20944 fis, clone A	1.35E−06	1.08
421759	AA027968	Hs. 107979	small membrane protein 1	4.31E−05	1.08
434645	AF255303	Hs. 112227	membrane-associated nucleic acid binding	1.47E−08	1.08
435632	AF220049	Hs. 43549	uncharacterized hematopoietic stem/proge	3.86E−04	1.08
410196	AI936442	Hs. 59838	hypothetical protein FLJ10808	3.40E−05	1.08
430010	AI434760	Hs. 279949	KIAA1007 protein	2.32E−03	1.08
402007			C18000503: gi|8922165|ref|NP_060080.1| h	3.30E−03	1.08
423303	AW593818	Hs. 186421	ESTs	6.72E−03	1.08
445529	H14421	Hs. 180513	ATP-binding cassette, sub-family A (ABC1	2.31E−04	1.08
414038	BE242722	Hs. 180040	hypothetical protein FLJ22439	3.84E−05	1.08
456640	AW207000	Hs. 126857	Homo sapiens cDNA FLJ12936 fis, clone NT	2.91E−07	1.08
450649	NM_001429	Hs. 25272	E1A binding protein p300	3.10E−03	1.08
422461	NM_003417	Hs. 117077	zinc finger protein 264	4.28E−04	1.08
411850	AK002033	Hs. 72782	hypothetical protein FLJ11171	6.36E−04	1.08
433847	AA610266	Hs. 3631	ESTs	5.50E−04	1.08
431049	AA846576	Hs. 103267	hypothetical protein FLJ22548 similar to	1.17E−05	1.08
400967			Target Exon	2.95E−03	1.08
415987	R41275	Hs. 346886	gb: yf85c07.s1 Soares infant brain 1NIB H	2.19E−04	1.08
414427	L19711	Hs. 76111	dystroglycan 1 (dystrophin-associated gl	5.18E−07	1.08
416039	AA376989	Hs. 78989	alcohol dehydrogenase 5 (class III), chi	2.67E−05	1.08
438951	U51336	Hs. 6453	inositol 1,3,4-triphosphate 5/6 kinase	7.07E−04	1.08
427979	BE379776	Hs. 181309	proteasome (prosome, macropain) subunit.	1.02E−05	1.08
419852	AW503756	Hs. 286184	hypothetical protein dJ551D2.5	8.58E−06	1.08
456115	F01082	Hs. 172004	titin	3.41E−03	1.08
416396	R91986	Hs. 209508	ESTs, Moderately similar to ALU1_HUMAN A	7.17E−05	1.08
419080	AW150835	Hs. 18878	hypothetical protein FLJ21620	3.78E−05	1.08
421013	M62397	Hs. 1345	mutated in colorectal cancers	9.61E−04	1.08
425465	L18964	Hs. 1904	protein kinase C, iota	1.12E−04	1.08
433198	AA992841	HS27263	KIAA1458 protein	4.26E−03	1.08
456792	BE502835	Hs. 15463	Homo sapiens, clone IMAGE: 2959994, mRNA	2.30E−05	1.08
424904	AI221739	Hs. 96899	ESTs	2.08E−03	1.08
439655	AI925740	Hs. 91559	ESTs, Weakly similar to S72576 hypotheti	2.14E−03	1.08
409026	AL137554	Hs. 49927	protein kinase NYD-SP15	9.99E−05	1.08
430715	AC004908		Homo sapiens PAC clone RP5-855D21	2.72E−06	1.08
456647	AI252640	Hs. 110364	peptidylprolyl isomerase C (cyclophilin	4.65E−06	1.08
429261	AW176254	Hs. 342389	ESTs	3.21E−03	1.08
451813	NM_16117	Hs. 27182	phospholipase A2-activating protein	7.17E−05	1.07
438117	AA328041	Hs. 194329	hypothetical protein FLJ21174	6.88E−07	1.07
451326	AW296946	Hs. 256078	ESTs	5.35E−05	1.07
425116	AU076686	Hs. 154668	KIAA0391 gene product	1.18E−03	1.07
451938	AI354355	Hs. 16697	down-regulator of transcription 1, TBP-b	1.61E−06	1.07
450234	AI688524		ESTs	2.54E−04	1.07
411739	AW859623	Hs. 8262	lysosomal-associated membrane protein 2	1.96E−03	1.07
445372	N36417	Hs. 144928	ESTs	1.34E−03	1.07
421522	R48881	Hs. 102991	hypothetical protein FLJ13956	9.67E−03	1.07
419426	AI214690	Hs. 346257	aldo-keto reductase family 1, member B1	2.34E−05	1.07
459126	AA478866	Hs. 288809	hypothetical protein FLJ20159	2.40E−04	1.07
417395	BE564245	Hs. 82084	integrin beta 3 binding protein (beta3-e	9.69E−03	1.07
445133	AW157646	Hs. 198689	ESTs	3.39E−03	1.07
417688	R09170	Hs. 284350	ESTs	1.12E−05	1.07
432858	BE618609	Hs. 279591	Homo sapiens clone 25056 mRNA sequence	3.83E−05	1.07
439363	AW979183	Hs. 292414	ESTs, Weakly similar to I38022 hypotheti	8.83E−03	1.07
452260	AA453208	Hs. 330994	RAB9, member RAS oncogene family	4.08E−05	1.07
449838	AB020653	Hs. 24024	KIAA0846 protein	9.84E−04	1.07
451900	AB023199	Hs. 27207	KIAA0982 protein	8.47E−07	1.07
450014	N41322	Hs. 18441	ESTs	2.19E−06	1.07
414257	AI828600	Hs. 21124	ESTs, Weakly similar to ALU8_HUMAN ALU S	8.09E−05	1.07
424906	AI566086	Hs. 153716	Homo sapiens mRNA for Hmob33 protein, 3′	5.69E−04	1.07
404497			Target Exon	5.11E−04	1.07
448598	NM_005701	Hs. 21577	RNA, U transporter 1	4.71E−07	1.07
423767	H18283	Hs. 132753	F-box only protein 2	3.06E−04	1.07
454514	AW802838		gb: IL2-UM0076-130500-084-B12 UM0076 Homo	5.61E−04	1.07
441356	BE384361	Hs. 182885	ESTs, Weakly similar to JC5024 UDP-galac	6.59E−06	1.07
426378	U80082	Hs. 169600	KIAA0826 protein	4.00E−04	1.07
428420	AL096858	Hs. 184245	KIAA0929 protein Msx2 interacting nuclea	8.62E−09	1.07
453827	AF201948	Hs. 35660	BUP protein	5.87E−07	1.07
454462	AW754153	Hs. 155976	cullin 4B	5.88E−03	1.07
427120	R42099	Hs. 21965	ESTs	3.67E−04	1.07
427297	AW292593	Hs. 334907	Homo sapiens, clone MGC: 17333, mRNA, com	3.42E−06	1.07
408876	AI961060	Hs. 129908	KIAA0591 protein	4.75E−04	1.07
445929	AI089660	Hs. 323401	dpy-30-like protein	1.14E−05	1.07
457913	AA748613	Hs. 311977	ESTs, Highly similar to SWI/SNF related,	4.55E−03	1.07
409278	AA346683	Hs. 52763	anaphase-promoting complex subunit 7	1.06E−03	1.07
430939	AI269471	Hs. 187018	ESTs	5.61E−03	1.07
450943	AA020964	Hs. 24734	oxysterol binding protein	6.29E−03	1.07
449893	T97999	Hs. 18214	ESTs, Weakly similar to B34087 hypotheti	1.03E−03	1.07
428821	H91282	Hs. 286232	Homo sapiens cDNA: FLJ23190 fis, clone L	4.16E−03	1.07
449540	AA001713		gb: zh86e08.s1 Soares_fetal_liver_spleen—	1.69E−03	1.07
447060	H79103	Hs. 270997	ESTs, Weakly similar to S47072 finger pr	9.50E−05	1.07
404692			Target Exon	4.70E−04	1.07
421307	BE539976	Hs. 103305	Homo sapiens mRNA; cDNA DKFZp434B0425 (f	1.04E−04	1.07
440523	AW501153	Hs. 7243	ubiquitin specific protease 24	8.40E−07	1.07
418627	AL079835	Hs. 86858	ribosomal protein S6 kinase, 70 kD, polyp	2.28E−05	1.07
439427	AA938150	Hs. 190534	ESTs	4.17E−04	1.07
451923	BE019040	Hs. 27258	calcyclin binding protein	3.75E−05	1.07
405166			Target Exon	1.21E−03	1.06
434825	N87549	Hs. 125287	zinc finger protein ZNF140-like protein	3.48E−06	1.06
425395	NM_014102	Hs. 156243	PRO1848 protein	1.37E−05	1.06
422008	AJ000534	Hs. 110708	sarcoglycan, epsilon	1.10E−05	1.06
407656	AW747986	Hs. 37443	Homo sapiens mRNA; cDNA DKFZp434B2119 (f	1.28E−05	1.06
433935	AF112208	Hs. 44163	13 kDa differentiation-associated protein	8.27E−07	1.06
446045	AV656268	Hs. 209153	angiopoietin-like 3	7.72E−05	1.06
444156	AW500059		ESTs, Highly similar to AF219140 1 gastr	1.00E−04	1.06
407621	AA128805	Hs. 6815	Homo sapiens, clone IMAGE: 3626458, mRNA,	8.90E−07	1.06
409506	NM_006153	Hs. 54589	NCK adaptor protein 1	6.83E−03	1.06
458287	AA987556	Hs. 12867	ESTs	1.25E−03	1.06
454552	AW806924		gb: QV4-ST0023-160400-172-h10 ST0023 Homo	5.69E−03	1.06
408931	AA251995	Hs. 334648	poly(A) polymerase alpha	5.04E−03	1.06
417414	AA434589		dUTP pyrophosphatase	1.69E−04	1.06
405270			NM_018850*: Homo sapiens ATP-binding cass	5.68E−03	1.06
421544	AK001445	Hs. 105633	hypothetical protein FLJ10583	7.06E−04	1.06
449881	Z28444	Hs. 24119	Homo sapiens mRNA; cDNA DKFZp586G2222 (f	1.68E−04	1.06
450295	AI766732	Hs. 210628	ESTs	2.38E−03	1.06
413530	AA130158	Hs. 19977	ESTs, Moderately similar to ALU8_HUMAN A	9.93E−04	1.06
422622	AW753452	Hs. 118757	enhancer of rudimentary (Drosophila) horn	6.78E−04	1.06
410602	AI370306	Hs. 158622	ESTs	4.91E−04	1.06
453959	Z18859		guanine nucleotide binding protein (G pr	4.95E−04	1.06
436503	AJ277750	Hs. 183924	ubiquitin associated and SH3 domain cont	9.83E−04	1.06
424459	R56570	Hs. 50547	ESTs	1.03E−03	1.06
433230	AW136134	Hs. 220277	ESTs	1.55E−05	1.06
453436	AW504292	Hs. 193261	ESTs	1.05E−04	1.06
459097	AW062839	Hs. 154230	nuclear domain 10 protein	5.24E−03	1.06
426934	AI301623	Hs. 172918	hypothetical protein	1.56E−05	1.06
449240	AF107455	Hs. 334540	Homo sapiens, clone IMAGE: 4138787, mRNA,	3.35E−03	1.06
439195	H89360		gb: yw28d08.s1 Morton Fetal Cochlea Homo	2.58E−03	1.06
440367	BE091101	Hs. 188606	ESTs	1.63E−05	1.06
431689	AA305688	Hs. 267695	UDP-Gal: betaGlcNAc beta 1,3-galactosyltr	8.24E−03	1.06
409598	NM_014018	Hs. 55097	mitochondrial ribosomal protein S28	1.16E−06	1.06
402109			Target Exon	547E−03	1.06
437207	T27503	Hs. 15929	hypothetical protein FLJ12910	8.55E−05	1.06
430607	AW973521	Hs. 247324	mitochondrial ribosomal protein S14	5.97E−04	1.06
420893	AK001326	Hs. 100090	tetraspan 3	1.73E−06	1.06
422868	AA425589	Hs. 121076	peptidylprolyl isomerase (cyclophilin)-l	1.42E−05	1.06
418977	AA233094	Hs. 191517	ESTs	2.97E−03	1.06
411388	X72925	Hs. 69752	desmocollin 1	1.80E−03	1.06
440417	AW298070	Hs. 278675	ESTs	1.24E−04	1.06
448780	W92071	Hs. 22033	Human DNA sequence from clone 366N23 on	6.62E−06	1.06
452405	AW451241	Hs. 225641	hypothetical protein FLJ13171	4.88E−07	1.06
439259	BE464643	Hs. 242322	ESTs	1.85E−03	1.05
423652	AF052122	Hs. 130712	Homo sapiens clone 23929 mRNA sequence	1.77E−03	1.05
409939	AA463437	Hs. 11556	Homo sapiens cDNA FLJ12566 fis, clone NT	9.73E−06	1.05
403363			Target Exon	6.72E−03	1.05
406023			Target Exon	5.18E−04	1.05
416363	T78325	Hs. 81001	F-box only protein 25	6.64E−03	1.05
441736	AW292779	Hs. 8182	ESTs	2.58E−03	1.05
403185			Target Exon	5.61E−04	1.05
432538	BE258332	Hs. 278362	male-enhanced antigen	9.50E−04	1.05
447042	AB035863	Hs. 182217	succinate-CoA ligase, ADP-forming, beta	1.08E−06	1.05
450631	AW139773	Hs. 246827	ESTs	8.76E−03	1.05
453195	BE241876	Hs. 32352	hypothetical protein DKFZp434K1210	1.16E−04	1.05
407596	R86913	Hs. 107622	gb: yq30f05.r1 Soares fetal liver spleen	2.86E−03	1.05
431752	AW337166	Hs. 43018	ESTs	4.94E−04	1.05
445637	W58459	Hs. 8949	hypothetical protein MGC4172	4.47E−05	1.05
424285	BE207168	Hs. 144630	nuclear receptor subfamily 2, group F, m	2.95E−04	1.05
408395	BE072425	Hs. 44579	hypothetical protein FLJ20199	8.66E−05	1.05
420825	AI656727	Hs. 194657	gb: tt53f12.x1 NCI_CGAP_GC6 Homo sapiens	1.85E−05	1.05
414291	AI289619	Hs. 13040	G protein-coupled receptor 86	2.40E−06	1.05
406922	S70284	Hs. 119597	gb: stearoyl-CoA desaturase [human, adipo	2.97E−04	1.05
438805	AA826048	Hs. 117887	ESTs	8.57E−04	1.05
400223			Eos Control	1.09E−04	1.05
432332	AA305351	Hs. 274369	uncharacterized hypothalamus protein HAR	2.30E−03	1.05
413628	L42542	Hs. 75447	ralA binding protein 1	1.23E−07	1.05
454067	AA041455		ESTs	2.09E−04	1.05
442965	AL134235	Hs. 222442	ESTs	8.21E−03	1.05
422174	AL049325	Hs. 112493	Homo sapiens mRNA; cDNA DKFZp564D036 (fr	1.08E−03	1.05
431799	AK000283	Hs. 270502	hypothetical protein FLJ20276	1.53E−03	1.05
413004	T35901	Hs. 75117	interleukin enhancer binding factor 2, 4	1.60E−03	1.05
442092	AW578669		hypothetical protein FLJ12439	6.77E−04	1.05
424201	L33075	Hs. 1742	IQ motif containing GTPase activating pr	2.54E−04	1.05
415673	BE242249	Hs. 78592	eukaryotic translation initiation factor	4.67E−05	1.05
424909	S78187	Hs. 153752	cell division cycle 25B	3.66E−05	1.05
432467	T03667	Hs. 239388	Human DNA sequence from clone RP1-304B14	3.85E−03	1.05
429623	NM_005308	Hs. 211569	G protein-coupled receptor kinase 5	6.02E−03	1.05
403611			NM_017886*: Homo sapiens hypothetical pro	4.13E−04	1.05
449517	AW500106	Hs. 23643	serine/threonine protein kinase MASK	8.52E−05	1.05
422480	AB029016	Hs. 117333	Homo sapiens mRNA for KIAA1093 protein,	8.52E−03	1.05
440719	AA150869	Hs. 26267	ATP-dependant interferon response protei	6.72E−03	1.05
420520	AK001978	Hs. 98510	similar to rab11-binding protein	1.06E−04	1.05
409439	AW390511	Hs. 288862	Homo sapiens cDNA: FLJ21260 fis, clone C	2.58E−03	1.05
430504	H52761		Homo sapiens, clone MGC: 12617, mRNA, com	9.26E−05	1.05
429750	AB007916	Hs. 214646	KIAA0447 gene product	3.20E−05	1.05
438887	R68857	Hs. 265499	ESTs	5.09E−04	1.05
447726	AL137638	Hs. 19368	matrilin 2	2.15E−03	1.05
448859	BE272446	Hs. 265317	hypothetical protein MGC2562	8.34E−04	1.05
409132	AJ224538	Hs. 50732	protein kinase, AMP-activated, beta 2 no	9.27E−09	1.04
446838	AW978336	Hs. 20999	nucleolar protein p40; homolog of yeast	6.42E−05	1.04
426441	AA297257	Hs. 169907	glutathione S-transferase A4	4.55E−05	1.04
458096	AF052138	Hs. 6580	Homo sapiens cDNA: FLJ23227 fis, clone C	6.20E−04	1.04
406731	AI559131		gb: tq31g07.x1 NCI_CGAP_Ut1 Homo sapiens	3.80E−04	1.04
403707			Target Exon	9.16E−03	1.04
451572	AA018556	Hs. 268691	ESTs, Moderately similar to ALU2_HUMAN A	2.08E−04	1.04
434959	AW974949	Hs. 186564	ESTs, Weakly similar to I38022 hypotheti	8.06E−03	1.04
439802	R06364	Hs. 18001	ESTs	1.02E−07	1.04
457447	X78261		H. sapiens mRNA for TRE17 5′ extremity an	1.60E−03	1.04
425866	BE270097	Hs. 159971	SWI/SNF related, matrix associated, acti	2.57E−03	1.04
416065	BE267931	Hs. 78996	proliferating cell nuclear antigen	1.96E−07	1.04
426506	AW935187	Hs. 170162	KIAA1357 protein	7.93E−06	1.04
424088	AL049942	Hs. 139240	DKFZP564F1422 protein	2.35E−04	1.04
438374	AA321866	Hs. 6193	hypothetical protein FLJ14590	4.88E−03	1.04
455833	BE145360	Hs. 190064	ESTs, Weakly similar to I38022 hypotheti	1.77E−03	1.04
407874	AI766311	Hs. 289047	Homo sapiens cDNA FLJ14059 fis, clone HE	1.27E−08	1.04
432656	NM_000246	Hs. 3076	MHC class II transactivator	1.71E−03	1.04
413781	J05272	Hs. 850	IMP (inosine monophosphate) dehydrogenas	6.46E−03	1.04
449865	AW204272	Hs. 199371	ESTs	1.78E−08	1.04
452420	BE564871	Hs. 29463	centrin, EF-hand protein, 3 (CDC31 yeast	1.33E−06	1.04
423314	AI400661	Hs. 127811	disintegrin metalloproteinase with throm	1.34E−03	1.04
443303	U67319	Hs. 9216	caspase 7, apoptosis-related cysteine pr	1.41E−06	1.04
456175	BE241702	Hs. 79402	polymerase (RNA) II (DNA directed) polyp	8.45E−03	1.04
420179	N74530	Hs. 21168	ESTs	7.87E−04	1.04
410209	AI583661	Hs. 60548	hypothetical protein PRO1635	5.97E−04	1.04
434148	AW291716	Hs. 116113	Homo sapiens cDNA FLJ14182 fis, clone NT	1.60E−03	1.04
459274	AA382590	Hs. 46366	KIAA0948 protein	1.05E−06	1.04
450848	AI677994	Hs. 428	fms-related tyrosine kinase 3 ligand	5.70E−04	1.04
411580	AL080088	Hs. 70877	DKFZP564K2062 protein	3.19E−06	1.04
436523	BE612990	Hs. 5212	single-strand selective monofunctional u	3.67E−03	1.04
428137	AA421792	Hs. 170999	ESTs	8.38E−04	1.04
426494	AL119528	Hs. 170098	KIAA0372 gene product	1.22E−03	1.04
434805	AW974666	Hs. 293024	ESTs	3.83E−03	1.04
455679	BE066529		gb: RC3-BT0333-300300-017-a12 BT0333 Homo	5.56E−04	1.04
437739	AW579216	Hs. 264610	ESTs, Moderately similar to Ibd1 [H. sapi	3.46E−05	1.04
412672	AA158910	Hs. 74441	chromodomain helicase DNA binding protei	2.77E−03	1.04
447749	T53260	Hs. 191091	ESTs	4.48E−05	1.04
452461	N78223	Hs. 108106	transcription factor	7.56E−04	1.04
447915	AW450650	Hs. 20013	GCIP-interacting protein p29	1.82E−05	1.04
447030	AW444659	Hs. 232184	ESTs	9.89E−03	1.04
430919	AA489041	Hs. 295448	ESTs	1.01E−03	1.04
406684	X16354	Hs. 50964	carcinoembryonic antigen-related cell ad	4.34E−04	1.03
433882	U90441	Hs. 3622	procollagen-proline, 2-oxoglutarate 4-di	2.44E−04	1.03
430534	AA480908		gb: aa28f09.s1 NCI_CGAP_GCB1 Homo sapiens	3.51E−03	1.03
413010	AA393273	Hs. 75133	transcription factor 6-like 1 (mitochond	1.08E−05	1.03
409490	AA075064		gb: zm85e12.s1 Stratagene ovarian cancer	2.11E−03	1.03
422231	AA443512	Hs. 101383	ESTs	3.11E−04	1.03
425376	H10612		gb: ym08f03.r1 Soares infant brain 1NIB H	2.49E−03	1.03
434733	AI334367	Hs. 159337	ESTs	1.56E−04	1.03
425973	BE379570	Hs. 165439	arsA (bacterial) arsenite transporter, A	1.41E−03	1.03
458477	NM_000314	Hs. 10712	phosphatase and tensin homolog (mutated	2.73E−04	1.03
440708	AF038962	Hs. 7381	voltage−dependent anion channel 3	1.07E−04	1.03
412338	AA151527	Hs. 69485	hypothetical protein FLJ12436	1.38E−05	1.03
424277	AA338057	Hs. 29131	nuclear receptor coactivator 2	1.94E−03	1.03
427625	AF008216	Hs. 285013	putative human HLA class II associated p	2.54E−03	1.03
410017	AW952426	Hs. 109438	Homo sapiens clone 24775 mRNA sequence	6.00E−06	1.03
404124			Target Exon	6.53E−04	1.03
446895	AA166655	Hs. 26860	ESTs	8.18E−05	1.03
448848	AF131851	Hs. 22241	hypothetical protein	1.70E−03	1.03
403292			Target Exon	4.58E−03	1.03
425728	T84535	Hs. 303001	Homo sapiens cDNA: FLJ21335 fis, clone C	3.27E−03	1.03
437440	AA846804		ESTs	1.45E−03	1.03
433486	AW976937	Hs. 54452	ESTs, Weakly similar to T00329 hypotheti	7.37E−06	1.03
445790	AV655170	Hs. 49015	chromosome 21 open reading frame 35	4.70E−03	1.03
424139	D86979	Hs. 141296	KIAA0226 gene product	1.13E−05	1.03
451658	AW195351	Hs. 250520	ESTs, Moderately similar to I38022 hypot	7.97E−06	1.03
458409	AV645567	Hs. 120391	ESTs	7.85E−04	1.03
425210	AA054679	Hs. 155150	ribonuclease P (14 kD)	1.78E−03	1.03
429762	AI346255	Hs. 216354	ring finger protein 5	5.43E−06	1.03
449578	AL050331	Hs. 284141	KIAA0721 protein	5.02E−06	1.03
440244	AI743977	Hs. 205144	ESTs	5.07E−04	1.03
453784	AA456246	Hs. 271541	Homo sapiens cDNA FLJ11653 fis, clone HE	3.05E−04	1.03
453327	AW500180		tryptophanyl-tRNA synthetase	1.81E−05	1.03
422298	NM_005683	Hs. 114545	G protein-coupled receptor 55	1.63E−04	1.03
428384	M54968		v-Ki-ras2 Kirsten rat sarcoma 2 viral on	7.06E−04	1.03
447982	H22953	Hs. 137551	ESTs	1.77E−05	1.03
436911	AA142984	Hs. 5344	adaptor-related protein complex 1, gamma	1.96E−03	1.03
421873	AI132988	Hs. 109052	chromosome 14 open reading frame 2	2.16E−05	1.03
432221	M21191	Hs. 273415	aldolase A, fructose-bisphosphate	4.65E−03	1.03
403027			C21000364*: gi|8394509|ref|NP_058778.1|u	2.37E−04	1.03
449845	AW971183	Hs. 6019	DnaJ (Hsp40) homolog, subfamily C, membe	1.48E−05	1.03
447221	AB007861	Hs. 17803	KIAA0401 protein	1.88E−05	1.03
419725	U66048	Hs. 92683	Homo sapiens clone 161455 breast express	1.11E−05	1.03
456863	T16837	Hs. 4241	ESTs	1.83E−05	1.03
430599	NM_004855	Hs. 247118	phosphatidylinositol glycan, class B	1.54E−04	1.03
426295	AW367283		zinc finger protein 6 (CMPX1)	1.72E−06	1.03
414312	AA155694	Hs. 191060	ESTs	1.81E−04	1.03
428484	AF104032	Hs. 184601	solute carrier family 7 (cationic amino	9.02E−08	1.03
452019	AL157503	Hs. 27552	Homo sapiens mRNA; cDNA DKFZp586N2424 (f	6.94E−04	1.02
445896	W37944	Hs. 4007	Sarcolemmal-associated protein	8.01E−04	1.02
452606	N45202	Hs. 90012	hypothetical protein FLJ23441	9.66E−04	1.02
438940	AF075045	Hs. 271609	ESTs	5.84E−04	1.02
436685	W28661	Hs. 5288	Homo sapiens mRNA; cDNA DKFZp434M245 (fr	1.76E−05	1.02
407233	X16354	Hs. 50964	carcinoembryonic antigen-related cell ad	6.24E−04	1.02
432021	AA524470	Hs. 58753	ESTs	1.30E−04	1.02
444239	R57988	Hs. 10706	epithelial protein lost in neoplasm beta	2.69E−03	1.02
444461	R53734	Hs. 25978	ESTs, Weakly similar to 2109260A B cell	4.54E−03	1.02
439467	AW292275	Hs. 158365	ESTs	4.93E−03	1.02
417713	D42047	Hs. 82432	KIAA0089 protein	7.09E−04	1.02
443968	AA287702	Hs. 10031	KIAA0955 protein	2.40E−03	1.02
411400	AA311919	Hs. 69851	nucleolar protein family A, member 1 (H/	1.09E−05	1.02
406535			Target Exon	2.33E−05	1.02
426007	AA724983	Hs. 144743	ESTs, Weakly similar to AD08_HUMAN ADAM	4.26E−04	1.02
408103	AA992592	Hs. 42712	MAX protein	1.83E−08	1.02
436024	AI800041		ESTs	1.16E−05	1.02
448393	AW117691	Hs. 224517	ESTs, Moderately similar to hypothetical	5.08E−04	1.02
410277	R88621	Hs. 26249	ESTs, Weakly similar to T2D3_HUMAN TRANS	2.62E−03	1.02
443985	BE613332	Hs. 132055	ESTs, Weakly similar to GNMSLL retroviru	5.17E−03	1.02
420168	AF217508	Hs. 95594	serine carboxypeptidase vitellogenic-lik	7.46E−06	1.02
458649	AI291047	Hs. 49053	ESTs	1.64E−03	1.02
439462	AL133026	Hs. 6567	Homo sapiens mRNA; cDNA DKFZp434C136 (fr	1.26E−04	1.02
439871	R88518	Hs. 46736	hypothetical protein FLJ23476	5.31E−03	1.02
443724	AA446783	Hs. 288932	hypothetical protein FLJ13194	1.35E−03	1.02
408627	BE313882	Hs. 46659	DKFZP58612223 protein	3.10E−03	1.02
443291	AA325633	Hs. 136102	KIAA0853 protein	4.07E−04	1.02
441243	AI767056	Hs. 193002	ESTs	1.55E−03	1.02
419881	AA329340		mannosyl (alpha-1,3-)-glycoprotein beta-	3.38E−05	1.02
438081	H49546	Hs. 251391	claudin 16	3.84E−03	1.02
423456	AL110151	Hs. 128797	DKFZP586D0824 protein	3.80E−06	1.02
422090	W05345	Hs. 293884	ESTs	1.52E−05	1.02
433920	NM_000430	Hs77318	platelet-activating factor acetylhydrola	2.37E−04	1.02
411142	NM_014256	Hs. 69009	transmembrane protein 3	7.98E−04	1.02
437119	AI379921	Hs. 177043	ESTs	5.38E−04	1.02
414022	W44916		myosin regulatory light chain 2, smooth	2.93E−03	1.02
415524	F11541		gb: HSC2YD011 normalized infant brain cDN	5.94E−03	1.02
442119	AW970826	Hs. 6185	KIAA1557 protein	2.43E−03	1.02
440865	AI281525	Hs. 130180	ESTs	2.56E−03	1.02
449227	AJ403106	Hs. 121824	ESTs	3.98E−03	1.02
426224	BE085860	Hs. 168075	karyopherin (importin) beta 2	9.60E−07	1.02
435272	AA906415	Hs. 110041	ESTs	2.06E−03	1.02
449269	AI564682	Hs. 175870	ESTs	3.26E−05	1.02
438685	AA814034	Hs. 123581	ESTs	1.79E−03	1.02
422558	NM_006420	Hs. 118249	brefeldin A-inhibited guanine nucleotide	5.07E−05	1.02
441244	BE612935	Hs. 184052	PP1201 protein	1.09E−04	1.02
420473	AL118782	Hs. 300208	Sec23-interacting protein p125	2.28E−03	1.02
445504	NM_006590	Hs. 12820	SnRNP assembly defective 1 homolog	4.35E−03	1.02
437952	D63209	Hs. 5944	solute carrier family 11 (proton-coupled	7.25E−09	1.02
431109	AA492271	Hs. 143672	ESTs	3.55E−05	1.02
418535	R98238	Hs. 268874	ESTs, Weakly similar to ZN91_HUMAN ZINC	2.05E−03	1.02
425245	AI751768	Hs. 155314	KIAA0095 gene product	1.68E−05	1.02
445903	AI347487	Hs. 132781	class I cytokine receptor	4.56E−04	1.02
445558	R99105	Hs. 173522	ESTs	3.62E−03	1.01
410625	AI753267	Hs. 15220	zinc finger protein 106	5.62E−03	1.01
409162	H25530	Hs. 50868	solute carrier family 22 (organic cation	1.30E−04	1.01
411990	AW963624	Hs. 31707	ESTs, Weakly similar to YEW4_YEAST HYPOT	2.38E−04	1.01
419497	NM_006410	Hs. 90753	Tat-interacting protein (30 kD)	9.78E−05	1.01
428974	AA442693	Hs. 272006	ESTs, Weakly similar to I38022 hypotheti	3.99E−07	1.01
435014	BE560898	Hs. 10026	mitochondrial ribosomal protein L17	3.50E−03	1.01
430268	AK000737	Hs. 237480	hypothetical protein FLJ20730	1.21E−05	1.01
408340	AB037762	Hs. 44268	myelin gene expression factor 2	2.84E−06	1.01
410576	AI421612	Hs. 30864	ESTs	3.10E−03	1.01
444187	AW138466	Hs. 151274	ESTs	1.63E−03	1.01
430487	D87742	Hs. 241552	KIAA0268 protein	1.29E−05	1.01
431214	AA294921	Hs. 348024	v-ral simian leukemia viral oncogene hom	4.89E−04	1.01
428592	AA479487	Hs. 105642	Homo sapiens cDNA: FLJ23271 fis, clone H	1.27E−04	1.01
412938	AU077050	Hs. 75066	translin	3.21E−06	1.01
414355	BE272157	Hs. 75925	proteasome (prosome, macropain) inhibito	4.98E−05	1.01
424026	AI798295	Hs. 137576	ribosomal protein L34 pseudogene 1	2.24E−04	1.01
432975	AA331517	Hs. 286055	chimerin (chimaerin) 2	5.03E−03	1.01
419170	BE002798	Hs. 287850	integral membrane protein 1	3.08E−04	1.01
459428	AA258989		ESTs	5.76E−03	1.01
451579	AW607731	Hs. 26670	Human PAC clone RP3-515N1 from 22q11.2-q	4.45E−06	1.01
408128	N72794	Hs. 37716	ESTs, Weakly similar to ataxin-2-like pr	1.94E−03	1.01
412634	U55984		heat shock 90 kD protein 1, alpha	9.53E−05	1.01
425620	AA447450	Hs. 124219	hypothetical protein FLJ12934	3.30E−03	1.01
421829	AB018330	Hs. 108708	calcium/calmodulin-dependent protein kin	4.76E−05	1.01
434552	AA639618	Hs. 325116	Homo sapiens, clone MGC: 2962, mRNA, comp	3.66E−03	1.01
426348	BE466586	Hs. 17433	hypothetical protein FLJ20967	1.18E−04	1.01
458984	AA011185	Hs. 221189	hypothetical protein FLJ14431	3.93E−04	1.01
420112	NM_005109	Hs. 95220	oxidative-stress responsive 1	4.32E−03	1.01
437142	AI791617	Hs. 145068	ESTs, Moderately similar to A46010 X-lin	2.45E−04	1.01
410913	AL050367	Hs. 66762	Homo sapiens mRNA; cDNA DKFZp564A026 (fr	6.41E−05	1.01
422749	W01076	Hs. 278573	CD59 antigen p18-20 (antigen identified	7.76E−03	1.01
456926	AB018284	Hs. 158688	KIAA0741 gene product	5.40E−06	1.01
444745	AF117754	Hs. 11861	thyroid hormone receptor-associated prot	8.02E−05	1.01
416721	H80001		gb: ys65d09.r1 Soares retina N2b4HR Homo	4.32E−05	1.01
425218	NM_014909	Hs. 155182	KIAA1036 protein	4.15E−03	1.01
415724	NM_003580	Hs. 78687	neutral sphingomyelinase (N-SMase) activ	3.02E−06	1.01
419013	T90378	Hs. 14463	ESTs	2.26E−03	1.01
440461	R52728	Hs. 7193	KIAA1183 protein	4.24E−04	1.01
445760	AW370515	Hs. 13273	KIAA0592 protein	9.19E−07	1.01
422732	AA577455	Hs. 24937	transformer-2 alpha (htra-2 alpha)	3.04E−04	1.01
453528	AL137459	Hs. 33104	Huntingtin interacting protein C	5.40E−05	1.01
454900	AW838129		gb: QV2-LT0051-240300-097-g12 LT0051 Homo	7.63E−03	1.01
421395	D90084	Hs. 1023	pyruvate dehydrogenase (lipoamide) alpha	3.22E−04	1.01
414662	AL036058	Hs. 76807	major histocompatibility complex, class	6.04E−04	1.01
433505	AW504027	Hs. 15301	Homo sapiens cDNA FLJ12596 fis, clone NT	2.97E−05	1.01
431712	R26584	Hs. 267993	hypothetical protein FLJ10143	2.30E−05	1.01
432145	AB040890	Hs. 272759	KIAA1457 protein	1.58E−03	1.01
432878	BE386490	Hs. 279663	Pirin	3.32E−06	1.01
412025	AI827451	Hs. 24143	Wiskott-Aldrich syndrome protein interac	8.61E−06	1.00
408988	AL119844	Hs. 49476	Homo sapiens clone TUA8 Cri-du-chat regi	5.19E−04	1.00
430408	AA478540	Hs. 108336	ESTs, Weakly similar to ALUE_HUMAN !!!!	1.07E−05	1.00
419021	AI908330	Hs. 10554	hypothetical protein FLJ12761	2.11E−07	1.00
447188	H65423	Hs. 17631	hypothetical protein DKFZp434E2135	6.76E−04	1.00
409065	AB033113	Hs. 50187	KIAA1287 protein	1.25E−04	1.00
410868	T06529	Hs. 98518	Homo sapiens cDNA FLJ11490 fis, clone HE	5.88E−04	1.00
442462	AF031405		gb: AF031405 Soares fetal liver spleen 1N	1.37E−03	1.00
434665	AA642125		gb: nr60c01.s1 NCI_CGAP_Lym3 Homo sapiens	8.06E−03	1.00
435869	AF255910	Hs. 54650	junctional adhesion molecule 2	8.84E−04	1.00
405922			Target Exon	2.64E−03	1.00
400239			NM_001610: Homo sapiens acid phosphatase	2.26E−04	1.00
419632	AK000155	Hs. 91684	Homo sapiens mRNA; cDNA DKFZp667I103 (fr	5.91E−03	1.00
431857	W19144	Hs. 271742	ADP-ribosyltransferase (NAD; poly (ADP-r	8.59E−06	1.00
438543	AA810141	Hs. 192182	ESTs	2.40E−06	1.00
458430	AV646505	Hs. 122155	ESTs	6.08E−03	1.00
445106	T10219	Hs. 12329	KIAA0697 protein	2.01E−04	1.00
422926	NM_016102	Hs. 121748	ring finger protein 16	3.85E−03	1.00
443956	Z45647	Hs. 107968	ESTs	3.22E−03	1.00
453128	AW026516	Hs. 31791	acylphosphatase 2, muscle type	2.24E−04	1.00
431195	AA503083	Hs. 79742	ESTs, Weakly similar to T29959 DNA-direc	1.99E−03	1.00
447348	AI270615	Hs. 18192	Ser/Arg-related nuclear matrix protein (	2.85E−04	1.00
455148	AW858403		gb: CM0-CT0341-181299-130-f04 CT0341 Homo	4.78E−03	1.00
434775	AA648983		ESTs	2.20E−05	1.00
433456	AA593447	Hs. 124296	ESTs	1.75E−03	1.00
410800	BE280421	Hs. 94499	ESTs	5.76E−05	1.00
447370	AW248150	Hs. 18349	mitochondrial ribosomal protein L15	1.29E−05	1.00
406238			Target Exon	1.03E−03	1.00
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: T-test p-value
R2: Difference of the average standardized value of Hep C+ Liver vs. the average standardized value of Hep C− Liver

[0366]

TABLE 11B
	CAT
Pkey	Number	Accession
414404	19538_5	BG036308 AW813969 AW579686 BE147476 AW813871 BE147474 BE147589 BE147582 AA767716 AW813960 AW813958
		BE147583
		AW813608 AW813612 AW813965 AW813954 BE706154 BF843546 AW813870 BE147801 AW813962 R80512 BG681408
		AA344564 AW370224
		BG614838 AW582118 AW582114 AW370227 W16712 BF209670 BG117739 BE762802 BE087964 BE888647 R89145
		BF342601 BI752591
		BG435038 AA166732 N79515 BF541709 N79567 BG503029
455705	77478_2	BF971018 BE513812 AA133359 AW581719 BF434402 AL600619 BG699731 BI551395 AW027136 AW055130 BF939512
		AI076048 H18584
		AW161061 AA864334 AI816101 BE049456 AW044012 AA954079 AI274682 AI370526 AW131990 AA853195 AA853191
		BG118295 AA761620
		BG705371 BF355591 BF336596 AA360497 H28072 BG198352 AW364709 H40926 H44214 AA836538 BI059563
437938	66997_1	U71456 AA482911 W78802 AW856538 BF737212 N36809 N35320 AA282915 AW505512 AI653832 W87891 AI961530
		T85904 H59397 R97278
		W01059 AI820532 T82391 AI820501 T63226 R66056 R67840 AW961101 AA337499 W37181 AA180009 AW205862
		AA988777 AA856975
		BF172457 BG751124 AI741346 AI950344 AI689062 AI872193 AW102898 AW173586 AI763273 AI890387 AW150329
		AI762688 AA488892
		AI356394 AI539642 AA642789 AI950087 BF589902 N70208 AA283144 AA488964 H60052 R97040 BF886630 AW967677
		AW971573 AW967671
		AI308119 AA251875 AA908598 AI819225 AI564269 AA908741 AA293273 AA969759 AW276905 AA044209 H83488
		T92487
452194	90339_1	AI694413 AW994700 AI912946 N73548 AI082035 AW271652 W24189 W24182 AI719718 AA024658
		AW810120 AW015394
		T79755 AA988043
		AI709339
437834	294580_1	BG110129 AW749287 BE535498 AW749299 AW749293 AW749302 AW749298 AW749291 AW749294
		AW749289 AW749288
		AW749296
		AA769294 AW749297 AW749295 AW749292 BE002573
419200	9531_1	BF036043 AW190446 BG194731 AW662036 AI445021 BE937550 AW818972 AW393132 AA834685 BF112058 AV721682
		H16423 AI270167
		AI857345 AA937302 AW818444 BE929780 BG498678 BF155010 BI598271 BI599811 BE161728 AW578737 AW753711
		AW379707 AW381918
		BG506608 AW028637 AW994240 BF887392 BF790073 AW381624 AV727105 BF439618 AA443174 AI018009 N42850
		AW573242 AI417258
		AA463483 AI676131 AI167170 AA836627 AA443828 AW592922 AA235129 AA730278 AW439062 AW474332 BI043239
		AW474342 BG708553
		AW362423 BF090028 BE827256 R16550 R39478 R39479 R94368 BG540916 BM314745 AA251087 D54231 D55274
		BF085805 D31589
		AW966405 AW994425 D81879 BE093545 AW901107 AA383529 BI021552 R56420 N39976 AA573281 H82595 AA234955
		BE093539 AW367006
		BF358697 BF366318 AA663856 BE702099 BF035969 AI267384 AI267232 BE348320 AA621574 AA861212 BF083343
		BF083341 AV745131
		D53074 AW954476 AW954472 AA376836 AV724531 D53063 C14928 AA093287 AA062638 BG483558 BE940050
		AA765954
		T70171 BE938775
		BE940057 053502 AW373300 AL118798 BM128728 AA193411 AW444709 AW952455 AI887612 BF431948 BI496876
		AI264159 BM128481
		AI624657 AI689301 AI969467 AA861685 AA251595 AA625761 AA872090 AI826790 AA328366 BE827416 R75951
		D56918 R68122 BE827384
		AL118797 AI184164 AA164411 BI495332 BE858113 AI863860 H00660 T69849 AW780389 C14667 BE934995
		BI018652 R92801 AA164410
		H00752 AW373305 AW373299 AW373302
434210	54921_1	AK057015 AI026834 BE857936 AA149091 AI742972 AW439172 AI253168 AA255613
		BF513175 AI005006 T03406
		AW338149 AA836442
		AA420530 R88566 AI611672 AA433916 AA442855 BF063008 AA812568 AI889706 AA715313 AA768539 AA767620
		AA665471 AA404380
		AA665612 BF056442 AA706388 AI650676 AA627448 AI141769 H78227 AW901852 H78221 BE701982 BF689273
		AA397464
		N33072 R60218
		AW968247 H14833 AA768305 AA043348 R56470 BF739832 R51827 AI474963 BG494574 AA149090 BF238154 AI802210
		BE000129 BF734513
		R41964 H21055 R85253 R17705 R40844 BF790218 BG388356 BF003037 AA703138 AA377348 W24822
416126	12435_2	AK057910 H24547 R46556 BI043624 H20063 R66415
406906
400244	12188_1	X79449 BC017853 AL121035 BF196384 AW119044 AI028023 AW451110 AI971911
		AW015069 AI079170 AI376367
		AI264113 AA829646
		AA737579 AA449679 AA740864 NM_001111 U18121 AL567297 BG773801 BF973874 AV687104 AA527579
		AA843525 BE706355 AI074589
		AI523475 BE890249 AW406263 BE074258 AV729485 BF809610 BG058619 AA677244 BE179838 AA622264 AI460106
		AA740411 AI499168
		AI078223 AI682923 BE696559 AW375385 AA788739 BG984978 240874 T17054 F09669 AW844043 U10439 BI711870
		AW245957 AU158567
		AA679305 AA679316 W72510 AI346029 BG059762 AW251062 AA132373 AI925621 AI860230 AI340172 AW192891
		AI707980 AI094937
		AI042115 AI200901 BE328452 AA644678 AA551209 BE351065 AA970761 N68609 AW002028 AA160826 AI422774
		AW873114 AW073597
		AW664483 AI218710 AW020550 AW190607 AI984545 AI871921 AI333970 AI452887 AI818335 AA398655 AI554424
		AI274187 BE465703
		AW512940 AW241366 AI923954 AA576649 AW168294 AA813181 AA912168 AI049738 AW514073 AA548255 AI569630
		BE710031 AA244182
		AI341697 AA563904 AI537990 AW517908 AW172943 Z39498 AI750294 AW150414 AI253293 BE825720 T31860
		AW150775
		D20310 AA150892
		AU133933 BE781148 AL038957 BF910979 AA352297 BG988142 AW372175 BF229106 AW866705 BE093482 BG990396
		AI499917 AA054452
		H05484 AI828502 BM467331 AU140570 AL135417 BF947202 AW391926 BE813418 BF998473 T92021 BI021048
		BM048783 AW501366
		AW501342 W501549 E939021 BE707147 BE160974 BE305207 N49011 AA947119 AA678801 BE536876 AW897428
		BG329648 BG818540
		BE542344 BI919250 BI253018 AW130996 BE074249 BE895428 BI034862 BE083277 BF952166
411837	1110600_1	AW866303 AW866402 AW866310 AW866282
406990	48529_1	S82075 AA327293
433489	1000815_1	AA594718 AI698673 AA907314 AW629150
411605	10026_3	BG256892 H10532 N46614 R52610 AW977696 BM460488 W56819 BI042183 BG977498 BE767451 BF870009 BG477472
		R61137 R14274
		R20259 R09686 BI838226 BF034269 AA429173 BE741829 AW867495 AI123683 AW006831 BE831162 AW452753
		AV742717 W86152
		BF115102 AI633815 BF921562 AA094230 BE092587 W86151 AA526153 AI672156 BF914496 R12579 BF852352 AA699780
		T57386 BF903022 R09933 AA678298
420292	2556_2	AW991897 AW991891 AW991894 AW991841 AW991840 AW991777 AW991797 AW991779 AW991766
		AW991774 AW991793 AW991786
		AW991782 AW991773 AW991783 AW991828 BF326561 AW991887 AW991888 AW991896 AW991901 AW991893
		AW991898 AW991895
		AW991902 AW991899 BF326532 AW991727 AW991742 AW991731 AW991738 AW991736 AW991739 AW991740
		AW991729 AW991741
		AW991730 AW991733 AW991804 AW991803 AW991808 AW991805 AW991801 AW991806 AW991802 AW991798
		AW991728 AW991807
		AW991776 AW991714 BF326565 BF326506 AW991726 AW991734 AW991732 BF326535 AW991800 AW991809
		BF326568 AW991900
		BF326518 BF326524 AW991716 AW991795 AW991718
442679	31783_3	BG621493 BI056706 BG496376 R53718 W65356 R79357 BG434247 AA357769 AW978686 BG573200 BF132113
		BF086709 AA366938 D79234
		BG494628 AA156754 BG434311 AW978683 AW273417 BM054662 AI799886 AI433351 AI160798 AW33742
		BF056186 AI281606 AW015046
		AI439585 AI245530 AI078267 AA807170 AA837395 W61252 AA831085 AA287371 AW768354 AA890606 AI302539
		AI708575 AI673031
		AI242260 AW514069 AA283958 AA825452 AI371234 AA425696 AA453422 AA827697 R23653 D20240 AA772517 H13802
		R66972 R79360
		R27351 F03379 AA031952 N69504 R33143 R79358 R39136 R38800 R15089 R52937 R37502 H01021 R33634 R46551
		Z40404 BG291052
		BG570357 AW391046 BG496872 H23558
446526	11131_17	AK023419 BE464935 BE221668 AI148885 BI859909 AI374780 AA766892 AI347967 AI582917 AA477117
		AA229236 AA652637 AA636109
		AU134580 F21298 BF802607 BE769124 AV658891 H89616 AV659853
451752	10408_5	AB032997 AI141678 AW978722 BE467119 AI761408 BF727385 AW237035 AI934521 BF436248 AI479668
		Z40632 AA832081
		AW295901
		BF057835 BE465977 AI621269 BE465983 BF756369 N74056 AI817896 AA716567 AA934774 H62600 H09497 BF943762
		BE395335 BE883333
428342	6712_1	AK056315 AI015524 AA724079 BI713619 AI377728 AW293682 AI928140 AI092404 AI085630 AA731340 BM469629
		AW968804
		AA425658
		AA769094 BF446026 AW118719 AI332765 AW500888 AW576556 AI859571 AW499664 AW614573 AW629495 AW505314
		W74704 AI356361
		AI923640 AW070509 AI521500 AL042095 AA609309 AA761319 AI381489 H45700 AA761333 AW265424 AA909524
		AA635311 AA649040
		AI392620 Z40708 AI985564 AW263513 AA913892 AI693486 AW263502 AI806164 AW291137 BI061872 BI059498
		AA134476 AW084888
		AA036967 AW370823 T55263 BI002756 AA489664 BF827261 W74741 BF963166
421902	276321_1	BG171436 BE079601 BE079534 AA299964 BE392717 BE883402 BE079532 BE018148 BF889427 W00396
427043	2736_6	BF511666 BF447624 BF817650 AW974087 BF437901 BE504352 AA568952 AA460669 BE220596 AA397679 AI217920
		AA399531
421014	24169_1	NM_012227 Y14391 AK024630 BC014636 BG281479 AL556021 AW778818 BF196455 AW592274 AI376720
		BI438310 AW511106 AW304443
		AI568597 BE326797 BG056985 AI569473 AI475975 BF448109 AA853022 AI886592 BG755959 BI084711 BF683496
		BE177141 AI742415
		AW001158 BG747230 BI116434 AI984821 AW0816S9 AL543852 T08792 BF526529 AL582296 AA830141 AA789136
		H26527 AA425013 F32744
		N62859 AA535316 BE872483
455187	1107511_1	AW864071 AW864059 AW864056 AW864070 AW864050 AW864067 AW864072 AW864057 AW864065
459487	135353_1	AA699665 R84889
435374	129988_1	AI049889 AI733663 AA678730
425164	1276257_1	BM462532 R18189 R22638 R22639 AA351604 R17880
416435	18099_1	BF107196 BF804739 AA249165 AA227714 BI002580 BI254772 BE856761 AA843533 AI692783 AI769103 AI479234
		BF055564 AI332623
		AI560964 AI431301 BE675257 AA406642 AA707195 AI961161 AI218736 AI149261 AW474460 BE466679 AI989624
		AA765123 AA180333
		BF507849 AI281064 AI500253 AW468519 AI473781 AI263097 BF433898 AI912120 AI692780 AI262308 AI266734
		AA923774 AA227960
		BE644676 AI034302 AI352401 AI869528 AA862001 AI221573 AI565227 R60069 AW593430 N67562 AI346969
		AI925794 C21540 BG291961
		BG255029 BF852350 BF805364 BF852050 BE504626 BF432250 AW947402 AW071704 AW008413 BE717229 H94353
419560	16064_1	AB033081 AK074324 AW450283 BM128413 BE550945 BE670081 BE674137 AI298087 N30050 BF110807 N30072
		AI288098 N30068
		AW861931 AW858575 AI363734 AK025483 BF882045 BM128581 AW771330 BE669540 NM_016376 AB037360
		AA399607 R94364 BE514643
		BG684040 BG759578 T83725 AW858561 AW858524 H65293 AW754345 AK025960 BM477612 BE071291 BF087041
		BG995615 BE071350
		AI917153 AA436381 BE815318 AK025717 BE857148 AI741138 AW027718 BI789162 AI492263 AI690072 AI420179
		BI789249 AI637804
		AW957459 BF222458 AI094328 AW510893 AW295994 AI760430 BE464934 BE220458 AI042022 AI653315 BM128472
		AW337972 AW515837
		AI669489 AW664176 AI768730 AW271660 T16381 AI823834 AJ346113 AI242353 BF437578 AI273673 AW513498
		AI797424 AI674242 AI277236
		AW731756 AA373089 AW207589 AW467879 AL550999 N30075 BE883669 BF155456 AI423079 R60281 T16974
		BG676892 BF927070
		BI962758 BE811485 BE811591 BE811702 BE811600 BE811483 BE811533 BF927061 BG008257 BF873368
		AL574815 BF946447 H70934
		BF939868 BF378761 BE082381 BG984527 AA244447 BG983567 AW885571 AW293182 AW885607 AA811057
		AA610310 AI434406 AA514352
		H71020 BF740351 BE814815 N66648 AA737686 AI025403 AA255490 N26754 AI094233 AA629548 AA716234
		BF343632 AW363633 H62663
		N40757 N55959 AW858569 AW604731 N40773 N40777 T83895 AI905899 BG007487 BF820299 R60231 R60787 AA456130
		AW383736 BF087045 BG995619
441673	2674292_1	AI018657 AA952933
412556	1227313_1	AW961963 T08284 R14658
454877	195659_1	AW836463 AW836621 AW836541 AW836569 BF948429 AW836577 AW836640 BE072108 BF813547 BE072090
		BE072048
400137	22730_1	L42572 NM_006839 D21094 BC002412 D21092 AL581583 BG744690 BE890015 BM145018
		AW780309
		AW117715 AW273302 AI935295
		AI017768 AW117697 AA528074 BM091568 AW026362 AI807072 AI217643 AI754482 BE220790 AU150440 AA488365
		AU150883 AU149798
		AW136866 AI037898 AA948432 AL044717 BM091271 AA165119 AI572998 AI159802 AI420707 AA988336 AA465659
		AA773194 AU146496
		AA910663 AA584371 AI310749 AI305278 AI951728 AI266446 AI446326 AI283854 AI270681 AI016194 W26444 AI984515
		AA261848 AI498094
		AW514651 AA627739 BE887828 AI123491 AA868942 AA677859 AI809730 AI810303 AA496031 AI952462 AA996053
		AI184087 AA693666
		AA136578 AA773609 AW900608 AA928404 AW405313 AI907129 AI907123 AI986051 AU150633 AU153325 AU153368
		AU153017 AI285394
		AW592096 AI250862 AI869677 AI084968 AA857716 AA862132 AA931138 T96072 H71166 AU151501 AU153688
		AU150884 AU160131
		AU152428 AU151809 AU153189 AU152726 AU153115 AU153153 AA191478 AU152952 AA085945 AI092312 AA489369
		AU144684 R89265
		AU153572 AW969804 N62534 H04597 BE893641 BE613265 AA136661 AI912911 AA834897 AI886988 AI364744
		AA813233 H27147 AW874123
		AI263151 AW732074 AI439378 AI283359 AI203130 BF477675 T10242 AA528336 Z41162 AA502970 AI611989
		AI802818 AI907127 F03630
		AA427945 AA928575 AI926261 BE165012 AA188614 AA864217 F25274 AI264826 AI003178 AA115133 AA579080
		N64601 AA807718
		AA079255 W37786 H02330 T49457 R49175 H64168 AF148646 BC005983 AU142948 AU131105 BG388364 BM006108
		BM011315 BG459126
		AA631333 BI552181 BF220333 AU128630 AU128629 AU129731 AU120428 BI560973 AA075620 AW862160 AW411337
		AI906984 BE966671
418733	18099_4	BM473699 N33854 N35083 BE090367 AI306129 AA911920 AA633160 AI302415 AA609954
		AI365203 AA911919
		AW995271 AA234587
		BF996091 AW956344 AW389533 R60133
400245	12188_1	X79449 BC017853 AL121035 BF196384 AW119044 AI028023 AW451110 AI971911 AW015069 AI079170 AI376367
		AI264113 AA829646
		AA737579 AA449679 AA740864 NM_001111 U18121 AL567297 BG773801 BF973874 AV687104 AA527579 AA843525
		BE706355 AI074589
		AI523475 BE890249 AW406263 BE074258 AV729485 BF809610 BG058619 AA677244 BE179838 AA622264 AI460106
		AA740411 AI499168
		AI078223 AI682923 BE696559 AW375385 AA788739 BG984978 Z40874 T17054 F09669 AW844043 U10439 BI711870
		AW245957 AU158567
		AA679305 AA679316 W72510 AI346029 BG059762 AW251062 AA132373 AI925621 AI860230 AI340172 AW192891
		AI707980 AI094937
		AI042115 AI200901 BE328452 AA644678 AA551209 BE351065 AA970761 N68609 AW002028 AA160826 AI422774
		AW873114 AW073597
		AW664483 AI218710 AW020550 AW190607 AI984545 AI871921 AI333970 AI452887 AI818335 AA398655 AI554424
		AI274187 BE465703
		AW512940 AW241366 AI923954 AA576649 AW168294 AA813181 AA912168 AI049738 AW514073 AA548255 AI569630
		BE710031 AA244182
		AI341697 AA563904 AI537990 AW517908 AW172943 Z39498 AI750294 AW150414 AI253293 BE825720 T31860
		AW150775 D20310 AA150892
		AU133933 BE781148 AL038957 BF910979 AA352297 BG988U2 AW372175 BF229106 AW866705 BE093482 BG990396
		AI499917
		AA054452
		H05484 AI828502 BM467331 AU140570 AL135417 BF947202 AW391926 BE813418 BF998473 T92021 BI021048
		BM048783 AW501366
		AW501342 AW501549 BE939021 BE707147 BE160974 BE305207 N49011 AA947119 AA678801 BE536876 AW897428
		BG329648 BG818540
		BE542344 BI919250 81253018 AW130996 BE074249 BE895428 BI034862 BE083277 BF952166
432053	11371_6	AL519914 AL562407 AA778932 BF111318 AW467038 AV729266 AI269598
		BE939277 AI026690 AW269662 AI024572
		BF909447 N58843
		R06838 R07017 T83038 R07054 T90358 N75259
406782	0_0	AA430373 AA968771
407644	27910_1	D16815 AL563603 BG399756 AI935028 N41813 L31785 AL529953 AA428473 AA401262 BF802576
		AA373868 BE886120 BM479352 T28309
		N57167 BI551531 BG037160
408731	11725_2	AF305826 BE350971 AI765355 AW172600 AI310231 BM271766 AI547292 AW612019 AI674617
		AW138666 AI147629 AI147620 BF857810
		BF886300 BF885952 BF886303 BF885956 BG565497 BE670834 AA114025 BF886396 BF886928 AV750861 D62864
436395	47269_1	AJ227900 BF512806 F00947 BG614207 BF103731 AA310707 AI094933 BM023235 AW051119
		BE882892 BG567751 BG567665 BG504662
		BG562750
435745	37547_1	AK056461 BG686518 BE387225 AW967059 BE297996 AL135538 BE294837 AW449002 AW451121
		T16848 AF055029 AL134724 W60898
		BE856266 AU148963 AW575704 AW152356 AI084072 AW054888 AI935155 AA284068 AW007543 AI986179 AI857721
		AW190129 AA150977
		BE208028 BF439037 AA833823 AI377038 BF941216 AI829982 AA468807 AA847169 AI218694 AI129353 AI934898
		AI184525 AI379211
		AW769491 AI307200 AI128809 N27928 AA431873 AA136861 AI750062 T03747 AA554767 AA450096 AI278743
		AA706407 AI039607 AI654580
		AI031667 AI061299 AA733104 AI359421 AI869544 AI200267 BI335847 BF589867 AW008863 AI471924 AI222650
		AW662717 AI803848
		AA887775 AI282703 AI246010 AA721306 AA470395 AI245744 F10546 F09656 N67194 C04809 Z38698 AW580747
		AA769725 AW374451
		AW953981 AW578740 BF887002 BE617814 BG685745 AW855788 AW578790 AW578794 BE767704 BF874200 BE767729
		AA365623
		AW057997 BE938847 BG572984 BE536806 BI598918 W76362 AA371887 BE703956 AA143026 AW578800 AW578799
		AW578802 AW578791
		AW578764 AA193300 AA284124 BF369529 BM458893 AW403361 F12947 AA336566 AA331865 T75183 H00830
		BM469137 BI256518
		AA344657 T08539 BG980264 AA873643 BI871195 N40688 H14973 AA337355 AW977829 AL134723 AW452446
		BE785578 BG977972
		AA317124 BE962224 BE962220 AW379371 BE935858
445447	6500_2	BF966635 BF672146 BE180458 AI686634 AA523860 AW271362 AI861821 BF431163 AI022823
		BF444980 AI765435 AA573781 BI712102
		AW612498 AI262492 AA398744 AA505593 AW196232 BF941119 AI685545 AW130178 AW044369 BF430926
		AI275587 AI025611 AI309750
		AA815111 AI149346 AI174556 AW003736 AI469520 AW992548 AI204623 AI270522 AI084323 AW576339
		AA922706 AI306116 AI554469
		AA825775 T03628 BE243372 AA436568 AW263457 AA587932 AA587928 AW262892 R79805 AI681690 AI681693
		AA393332 BE221894 N50660
		AA915886 BE702216 H24038 AA074283 R70676 AW576178 H01876 R81147 R81148 R76841 N27519 AW593637
414405	112689_1	AL047596 AA393792 AI670731 AI037957 AW874364 AI038137 N62286 AI241379
		BE501096 AW090696 AI927369 AI669226 AI369437 AI371075
		AW612409 AI686711 AI183289 AA477717 AI076122 AA635190 AA700984 AA781508 D81020 BF575223 AI356183
		D79312 AI375558 H61111
		BG283489 BE090666 BE090664 BE090662 H26545
445317	844744_1	AW468777 AI219856 AI873492
419439	62687_1	BC007205 BI757428 BG768253 BE793505 BI756175 BG700401 AW247795 BE378793
		AA485818 BG110861 BM006282
		AI003793 AI351302
		D80663 AI457745 AW248460 AA242934 AA456472 AL532788 AA536088 AW119049 AI472227 BF056172 AA827644
		AI688691 AI590089
		AI885138 AI885668 AW514618 AI368119 AI312763 AA587359 AI800927 AW629702 AI083644 AI306565 AI569261
		AI311737 AW514616
		AI309534 AI167269 AI220241 AI290334 AI352197 AA470701 AW613233 AA252032 AW248068 AA668416 AA252804
		AI038616 AA909996
		AA872009 AI272751 AI334419 AA454578 AI688702 AA485686 AA665245 AA878526 AI245998 AI871261 AW058650
		N31716 AI869672 H20492
		AA639593 R85327 AI951564 AI954026 BM007182 BI836891 BI758274 BI256473 BG331377 BG679123 AL532835
		BE393403 AI400134
		BG742026 BE389332 BI601732 BG698900 AA314318 BM006355 BI002658 BE252908 BG029560 BI196755 AA991163
423215	880395_1	AW963653 AA323281 AA372970 C16770
424571	9758_1	BE379766 AW152643 AI803450 AI564343 AI092711 AI140525 AW152156 AI620740 AI554689 AI161209
		AI290242 AI339745 AI374611 AI347388
		AI858296 AI140529 AI366124 AA493912 AA406235 AA493889 AI057160 AW022264 AI097277 AI144126 AI080051
		AA983529 AA860507
		N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004 AA626688 AA235977 AI057152 AI095366 AI095356
		AA458646 AW194479
		AA150439 AI375272 AW571777 AI359198 AA993793 BE614394 BE738239 AA127883 AI034344 T59504 D81608
		AA908704 AW051665
		AA382785 AA307208 N24639 AI370715 BE244980 AA548596 AW449675 AI191008 BF223749 N70752 N22266 AI191012
		AA028001 AI419106
		BF215661 BF591548 BG942356 AI474968 BE858217 BF793358 AV756758 BG483603 AI093724 BF693395 BG545345
		AI744294 T59549 AA811773 BG499757
422711	16701_1	AK055669 AL049378 AW377544 AI033709 AI472253 BI963224 AI743449 AA621561 AI749846 AW804052
		AW020579 AI097382 AA016179
		AI290937 AI016441 AA988531 AI339453 AW470330 AA931074 AA026185 BI491566 AA953819 D80556 AI479362
		BE856176 BE856995
		AI418530 AA453318 AA315363 AA974727 AU185136 BE817293 AI825808 AW117512 AA993526 AW517982 AI937289
		AW005886 BG034928
		AV716846 BG655435 BI964900 AW371588 AA811110 W31610 C15669 AW161626 AI683982 AA120857 BF222558
		N39089 AW261816
		AW167241 AW003602 AA873113 AI633319 AI953905 AA451704 AA287917 AA588470 AA134756 AA872118 AA554169
		N59186 BG655495
		AA026186 BF435907 BE049379 AA984507 AA987200 AI803323 BF445688 AW440533 AW439141 AW661740 R76524
		D60440 BF942226
		BI850115 AI432094 BF942170 AW262510 AA370302 AA885665 R62142 AI567199 C00263 BI495346 W15536 R37823
		AW673791 BF989408
		AA134662 BE300698 R15856 AI625064 AW591350 BM148617 D80991 BE004938 R76240 AV735001 D60083
444889	722791_1	AI201251 AI917770 AW293546
418751	21393_1	BF690141 BE159368 AI937311 AU151256 AW341542 AW274231 AW341609 AW450447
		AA843698 AW188066 AW007171 AW007027 AI075008
		AL520351 AA608992 AW151842 AA622181 AI273454 AI005661 AA205946 AA677899 AW473512 AW296620 AA872899
		AI094216 AI025188
		AA256998 AI539154 AI500192 AI289493 AI040740 BE167841 AW151374 BE167754 BF036108 AA299181 N23237 T62967
		W96060 AA574412
		AW606697 W96059 R51303 R09158 R59113 T48473 T59023 AA122066 AW606643 R38386 R06567
458196	60860_1	AK057790 AU159145 AI802408 BE856709 AI302762 AA907424 BE045678 AI302328 025594 N33153
		BE326823 AI863332 AV739134 AU149843
		AI279233 Z20793 AW173558
430718	583102_−3	AI792814
419175	35068_1	AB018322 BC012480 BI524873 AW665554 AI934469 AI479916 BF096179 BF096162 BF096132
		AA744972 AI951988 AI858339 BE076331
		AA886998 AI570585 AI916688 AI678811 AI693109 AI308135 AA669046 AA961064 AI018062 H80618 BE221942 R52609
		AI915164 AA365626
		Z44671 BI052776 BF882486 BG286184 AI589558 AA931663 AA534979 AI275392 AI273455 R52553 AA829920 H80652
		AA360728 F10618
		AW953666 AW176773 H85527 AA765570 AA081927 BF093262 BG743753 AL037576 AA534314 BE814964 BE973713
		N49493 BE006634
		BE006630 AW270037 AA234765 AI334004 BF057179 AI857450 AI341191 AI434143 AI917449 AW517207 AA255424
		AW008334 AA847572
		AA994211 AA861901 AA581873 AI580157 AI364363 AW242357 AW235291 N55645 AA319869 R36911 AA256551
		AW044188 AI203159 N49403
		F02090 AI187299 AI609644 Z40516 AW952314
446436	12330_1	BG474471 AW963784 AL541138 BI091480 AI023457 AV658395 BG991788 BG168902 AL568755 BF515750
		BG413457 AI073545 AI457986
		AA553973 AA826823 AI025831 AA722816 AI078414 AI252218 AA570134 AA313183 AI689327 AI609660 BI089971
		AW614345 BM145877
		AW182468 AI138446 AW054973 AI433252 BE392690 AA644254 AA621649 AI027916 H74280 H74279 R05903 BG504738
		BE243125 BG398720
442961	60316_2	BE966247 BE220885 BE467384 BE350135 BE672094 AI811582 AW665254 AA772731 AI283601 AA417067 AW197746
		AI868357 AI792143
		AA931120 AI758506 AA843761 BE737582 AW379586 N38812 BG567321 H13257
430844	450932_1	BM470823 AA487679 AV736625 T94960 T95013
434995	122184_1	AW974995 AI791196 AI821880 AI821932 AA659617 AI821137 AA658925
446096	2855992_1	AI633717 AI276454 AI275116
451050	11847_4	BM453041 AA760783 BE218582 AI340046 AW166131 BF515854 AI630296 AA461307 AI090881 AW023059 AA155797
		AA115486 AL597396
		AW889004 AW937420 AA137082 AA013374 BG619478 BG401839
443547	137089_2	AV645808 AA701657 AW271273 AI796734 AI472316 AI017531 AI061178 BF109096 AA548964 N83805 AA131648
		AA156589 BE708349
		AW952494 D30877 AV684717 Z24837 F00167 BF576150 T63841 R78995 N87474
449901	1269988_2	BI227033 AI674072
425996	138046_1	BM006551 AA367152 AW953705 AI631833 AW237429 AW027804 AA729038 BE503409 AI521935 BF739953
		AA702982 AA557633 AA780065
		AI218139 AW194264 D20120 AI082715 AI969980 BE857686 BE326711 AW953706 AI393749 AI383821 W67199 AI431759
		AI796526
		AI521794 AI796380 AW117545 AI749657 AI537634 N50122
448797	14543_1	BE614460 BF115119 AI670868 AW590674 AW003998 AI925103 AI521807 AI861967 AI765452 AI758865 AW028509
		AA708099 AA836286
		AI468465 AI208587 AW952300 AI824281 AA447219 AA468043 AI373421 AA708115 H13541 BF093497 AA461538
		BF377943 C01108 BF377920
		AV714521 AW206741 AW968126 AA774415 AI350171 AI275658
441969	2681178_1	AI733449 AI733386 AA972780 AA988876 AI791798 AI791748
441894	2338_5	BE869838 AI148042 AI827471 BG426916 AI684451 AI949551 AW006378 AA535914 BF222911 AI925829 AL044604
		AW769002 N62372 N52347
		AW002732 AI537926 AI886148 AA953912 BI862037 D61326 AA055633 BE544632 AW954810 N75119
433009	2142268_1	AA761668 AA573621 R09670 R92814
425913	4123_2	AV703649 AW959818 AI582119 AI523459 AI674473 AW663543 AA825476 AI935231 BF742805 AA426156 AI253626
		AA846477 AI024230
		BF221780 AI493027 AW006841 AA814699 H99650 AI088977 AA442691 AI783526 BF207915 AI752847
		AA782635 AI978980
		AA788634
		BG119454 BF678528 AI627829 BG993975 AV701283
443959	2780939_1	AL120546 AI093444
433359	1155535_1	H70007 AW896257 AW896334 AA584680 AW896386
435931	55043_1	AK057055 BI868744 AL537388 AL601343 BI917121 AW965676 BE163455 AA401842 BI836992 BE169604
		AW603254 BF224353 BI000120
		T09411 T33851 AL566789 AW383995 E504296 BE670066 BE221088 AW612265 A421866 AW044202 BG107771 BE621522
		AA400384
		AI668813 AI680704 BE855622 AL047416 AI085944 BE328123 AI951915 AI693159 AI633745 AI472220 AI127849
		AI601128 BF224203
		AA403117 AI624409 AW510999 AI199722 AI375679 AI369300 AW008158 BF437759 AI142992 AI299713 AA987655
		AA954216 AA081613
		D53173 N90948 N40544 AW172528 N94307 AW274872 AA833541 T03787 AI144167 AI678975 N58937 AI864431
		AI064741 AW664341
		BF222277 BE327850 AI625361 AI032746 N73790 W58072 AW204818 W02128 BF445630 AI073621 AA022615 AA084503
		AI215722 BE856978
		T56046 AI581993 AI139961 AI569338 AI207177 AI873359 AI682604 AI215528 AI700342 N90316 AA610054 F08873
		AI459512 AA676678
		BF589573 AI383046 AA947775 T90475 T90482 T33850 AA009789 W73132 H22902 F10123 H67882 T56062
		R11653 T89037 N27199 BE169725
		AA022614 D81394 AA502780 AI093041 T03878 W32393 N99415 AW418560 BE834542 AW197315 AI025774 BF793398
		AA994729 H50611 BE965743 BI766426 BE536391
434747	117643_1	AW976537 AI033582 AA837085 AA745261 AA648395
416727	1988165_1	W05023 N59520 H80405
400120	133_1	BC014030 NM_004068 BC004996 AK057883 D63475 BM468205 BG386792 BG750447 BG575842 BG479084
		BG741027 AU118129 BE901043
		AU141281 BG825395 BG338276 BE396231 AU121493 AU131489 BF341132 BG335659 BI769251 AU142779 AU124483
		BG480828 AU121353
		BG702326 AU137866 BG759046 BI460601 BE887290 BG750415 BF127710 BG757819 BI160266 AU122086 BG824046
		BG744180 BE884943
		BM006610 BG702599 BI870749 BF307033 BI334771 BG480606 AU142599 AU141336 BM018563 BI335565 AU138308
		BE391241 BG774488
		BE278025 BG717959 BG706920 BE312567 AU138300 BE303034 BE303016 AU139252 BE336797 BG470940 BE336735
		BF305197 AU134288
		AU139907 BE261245 BE208718 BG761912 BF212890 AW732692 BM011258 AW247629 AU136696 BF530078 BF204146
		AL048752 BG328927
		BE388385 BE260122 AU138789 BE253465 BF733914 AW249415 AW239535 BE311791 BE256236 BF529742 BG770465
		AW245777 AW245813
		BE296677 BE266852 BE168115 BE396596 BE280057 BE168229 AI750820 AU134137 BF792191 AI272215 AI907348
		AW238875 BF805152
		BF568397 BE712727 BE081443 BE001805 BF724536 BF744705 AW247385 BE796369 AU133759 AV705142 BE794402
		BM465821 BG281284
		AW384831 BM450689 AU134125 BE311650 BF356318 BM462831 BG420555 BE749127 AU134590 BM019438 BC013796
		BG761223 BG122058
		BE872076 BG748496 BG821374 BE619159 BG423244 AU137110 AU127210 BE270081 AA496860 AA351380 AA356303
		AU099781 AA355912
		AA371411 AA325535 U36188 AL569574 AL577204 AL525543 AL567342 AL567334 AL567122 AL536527 AL567098
		BG681585 BG824951
		BI870652 BI225855 AW393878 BG750632 BI223803 BE877552 BE270473 BE389392 BE779021 BM017845 81117816
		BE396513 BM049006
		AW393945 BE786941 BE267724 BE562981 BE314236 BF744102 BM019781 BF806063 BF828673 BF829181 BI008788
		BF829180 BF829175
		BF433802 BE909928 BF839784 AW578564 BF943095 AW328030 AA448596 AW882688 AA909846 BF924341 AW361460
		AA425174 BE940557
		BF761585 BF931276 BF934886 W68597 BF933977 BI035906 BE836064 BF837576 BI018368 AA205908 H54612 R88902
		BE812330 BE932300
		BF924562 AW805376 BE769859 R87381 AA371901 BE838855 AA326381 W56191 AA341231 AA464093 AL575977
		AL518650 AL547393
		BG338327 AL517563 AL536921 BG207096 BG207589 BG199290 BG220159 BG744842 BG104730 AA555035 AA618009
		AA861062 AA610582
		AW245418 AI040983 AA521380 AW245455 AU147292 AU155236 BE620286 AW250767 BF888236 BE620819 AU154343
		AU150827 AU148334
		AW069495 AA701091 AU155225 AW250019 AA666235 AU147764 AA449739 BF907598 AW043731 AU144390 AI924565
		BE300631 AW874021
		BE208088 BF732773 BF594057 AI159873 AU143930 N24100 AI052499 AI989370 AI366151 AI139248 AU144776
		AA838250 AI095433 AI269227
		BF811358 AU151352 AA477554 AI131290 AI049797 AU157349 AA620559 AA581533 AI338299 AA402755 AI050079
		AU157614 AI280691
		AA706590 BE206615 AA861056 AU153214 AU155712 AW069554 AI081124 AU155846 AI081123 AA719876 AI754976
		AI027763 AA723095
		BI518782 AW050706 F37521 R79062 AA565530 H39826 AA404670 AU158884 AI139682 AA513633 AI283202 AA651856
		AI623515 AA427413
		AW248474 BF841432 BM453246 AI302390 AA808269 AI249357 AA132775 AA716732 AA479932 AI198296 AI208674
		AI088433 F36977
		AA496899 AW615762 AA602541 AA341161 D58785 T15399 AI286077 W69152 F28418 AI272156 AA338034 AA568455
		BE206121 AI080033
		AI699680 AA861255 AI953465 AI613240 AL581773 AL531577 BF526361 AA657809 AW152670 BE621523 AW078705
		AW673719 AA102613
		AA195604 R72209 AA402208 AA404305 N24999 AI963535 D54741 BI461415 BM475959 BI260926 BI116213 BE280120
		BE940258 BE280044
		AI905744 BG001474 BE937718 BF799283 BI091621 BG421006 BG289235 BF736825 BI253429 BG170064 R72512 T92815
		BF931257
		BM455183 BG033362 BG574220 N31395 BF739185 AA371995 BE879011 BI198754 BF378989 T12266 BM019421
		BI194570 BF378992
		AW996595 BI858649 W94605 W61345 AA122384 AA171923 T92736 AA761504 AI819039 AI439358 AL517777 AL565919
		AA622001 AA642695
		AA704144 AA081465 AA070621 AA375562 AA700011 AA926863 W37310 AL566236 BF677809 BG760021 AW361433
		BE828605 BE268449
		BF805977 BG292452 BF981071 BF217108 BF928698 R33993 AW882841 AI857453 AW078733 AI433035 AI018103
		R90927 AA804720
		AA551734 R33835 H19741 R78754 BF930494 BG109583 AA631926 BE834008 BG996533
410972	480035_1	BG113822 AW812262 AW812259 AW812255
438021	45849_1	AY043361 NM_007013 AL136739 U96113 AL049041 AI750898 AA054855 BF887778 BF333173
		BI061338 BC015380 BG569062 BM090890
		AI769300 BE466554 AI091728 AI800660 AA832035 AI342285 AI750899 H66486 AA455942 H20821 AI187877 AI417440
		AW198099 AI245158
		T91227 AI373068 AW194829 AA680229 BG291204 AW885601 BF380168 D82380 D82098 BF885552 AL050082 BE552267
		AI458088
		AW137654 BM014715 AA418921 AI159868 AA845398 AI743920 AI159888 AI653531 AA843952 AI799752 AI360957
		R67562 BF445478
		AA854844 AA552895 C21152 BE614563 BI260650 AU155187 AW169673 AI915801 N29619 AA435618 AI361252 AI424627
		AI219018 R67514
		AA548141 AI246669 AA156867 R67561 R67513 AW263860 AA089478 AV653790 AA354846 BI560015 AW794547 R52020
		H18923 R67555
		AI302490 AL582101 AI871884 AW029104 AI582326 AV688960 AL040820 AI804339 T57931 R67554 AA418232
		AA393281 BE076206
		AW189435 AW979344 AW953494 BF056797 AA310720 N64062 W92065 AI761704 AA418824 H89156 H88930 W92048
		AW33096 AW007773
		AI745541 BE504125 AW243111 AI201009 AI187909 R44411 AI795988 BF222383 R29593 AA156952
		BF029856
411227	1073598_1	AW833298 AW833294 AW833272 AW833271 AW833274 AW833308 AW833275 AW833296
		AW833295 AW833258 AW833306
442751	1767112_1	BE567123 AI358404
446164	41648_2	AK026817 AI559708 AW273539 AW892986
450377	12109_1	AB033091 AL520743 BE811813 N53332 N99716 AL561910 AA280655 BE710392 AV705100 AW293978 AW444556
		AA281459 AI679751
		AI873695 BG700891 BI553517 R80518 BG779771 BG534451 AA479402 AW961580 BF061430 AI857643 AI768486
		AW512118 AA479302
		AW770384 AW072470 AI041596 AI049699 AW592865 AA976261 BE879747 BG114119 AW183811 AA909938 BF571621
		BF350794 BF351375
		BE925699 AL050294 BC010371 BF982270 AL042656 BF095732 AW812618 BF095731 BG212397 BF678765 BI038602
		BG388664 AW675337
		BG289398 BE939598 AW805570 AA527097 AW150540 AI693720 AA743364 AI915793 N48185 AI573107 AA043474
		AI351615 AI969490
		AI910763 R50866 AI699181 N73808 H08164
433991	2208777_1	AA824302 AI806816 AA621207 AA621208 AA912749
459169	3146528_1	AI905455 AI905452 AI905517
441458	306062_1	AW815108 BF928501 AW815254 AW815139 BE064292 AA935099 AA934531 BF955469 BI009962
421272	64950_1	BG819964 R87567 BF062036 BF062044 AW014470 BG057316 AI810506 BE466071 R88291 AA704157 C15898
		C15173 AA286825 BF594141
		R84605 H85515
400200	3806_1	BC005265 BG176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 AI092211 BI492387
		AI400449 AW166297 BF939910
		AA232282 AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 AI092748 AA993184 AI126077
		AI081758 AI240686
		AI261863 AI378423 AA465237 AI376096 AA035579 AI087306 AA448162 AA129977 AI090903 AI080686 AI288939
		N33004 AI801240
		AW021546
		AI370773 AI086064 AA669528 AI250053 AI870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283
		AW467587 H40506
		D00762 NM_002788 AA641134 AI582295 AI417525 AI563975 AI093566 AI707743 AI290741 AW073417
		BE875418 BM264076 BG876884
		AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991
		BE937569 BG878291
		BG876450 AW819099 AI908570 AA449871 AU135228 BM478404 BF126296 AA375499 AA248473
425261	MH337_5	AK054563 AF339812 AA528225 AI819825 BF434272 AW009758 BM023283 AI367158 AI954564 AA564676 BM353611
		AI151187 AW518909
		AI688072 BE207868 AA680236 AW001919 BE206150 AI814780 AW513625 AI204573 AW517297 AI276223 N49193
		AI868635 AA877533
		AW514291 T03476 M410444 AA973195 AI826725 AA662719 AW071134 AI620613 AI285995 AI241782 AI243244
		AI344384 AI017846 AI423377
		AI346069 AI399834 AI366843 AA814351 F25816 AA927979 AI141159 AA720769 AA953724 AI383799
		AI572402 AW002178 N29888 AW472873
		AW193742 AA614853 AI476008 AW771672 AW083617 AW591173 BM450662 AI922272 BM463462 BE879542 AA149308
		BG205668 R94706
		T98497 BF917910 BE964015 AI311930 BF303765 F22493 D20169 AA147668
435882	136881_1	AA701431 AW194987 AA704261 AA705688
450456	10568_3	BI869374 AW608173 AA481283 AA779091 AI091407 AI380767 AI161247 AA775262 AI804165 AA742296 AI620960
		BF057560 BE644921
		AI360753 AW271412 AA243424 AI082407 AA779083 AA670202 AA233657 AI032843 AW768251 AW016884 AW838625
		AA233693 AA766578
		AI246454 AI097182 AA774648 AA630743 H25879 AA233157 BF475907 AU153405 AI342173 T50088 N23013 AI817953
		W15432 AA404548
		AA009914 AW014445 AA243486 AA291931 N33512 BG987649 BF981538 BG619175 BG977894
450122	1398_1	BI830320 H45858 BI821969 AA834581 AA999871 BI831412 BI827162 BI826049 AA531076 AA327326 BF344394
		BI860338 BE382517 BI600376
		BI598227 BG754268 BI962938 BE907670 AI339466 BE222828 BE906305 AA662096 AI570621 AI088762 AI817835
		AI310480 BF725056
		AI669307 AI076748 BI966768 AI310414 BE158972 AW444735 AI333025 AI310004 BE393365 BF940054 BE858296
		AI498530 AI376399
		AI138476 AI289161 AI378371 BE857636 N40684 AI301684 AI370578 AI928410 AI568228 AI214670 BE782530 F19317
		AA468593 AI359175
		AI300708 BE070822 AA369484 AW959944 AA371588 BI604202 AI308854 AA636048 AA729907 BE743989 W42852
		AA644403 AA047301
		AA737174 BG054990 BF338479 AA948684 AA807788 AA844504 AI885673 AI927015 M662133 N98291 AA401721
		AA045902 T58832 W42908 BG996868 BI521617
445530	8558_4	BE294791 AA115300 BE677858 AW592684 BF061022 AI969919 H10240 AW183605 AI620788 F13488 AW468877
		BE172330 AA115340
		AV654146 D79658 T75088 T75087 R14638 D63008 BG623753 BG926180 R91348 AW885760 AA249136
		BG926100 BE175717 BE175718 C16690 Z42755
406815	0_0	AA833930 AI684135
457393	5773_1	AW970603 AA503455 M85475 AA503437
451436	5742_10	AA017575 R56724 BE836659 BE836660 BE817256 BE817335 AA258389 AA258459 BE817739 BE817702 BE817325
		BE836614
		BE139090
		AW861931 AW858575 AI363734 AK025483 BF882045 BM128581 AW771330 BE669540 NM_016376
		AB037360 AA399607 R94364 BE514643
		BG684040 BG759578 T83725 AW858561 AW858524 H65293 AW754345 AK025960 BM477612 BE071291 BF087041
		BG995615 BE071350
		AI917153 AA436381 BE815318 AK025717 BE857148 AI741138 AW027718 BI789162 AI492263 AI690072
		AI420179 BI789249 AI637804
		AW957459 BF222458 AI094328 AW510893 AW295994 AI760430 BE464934 BE220458 AI042022 AI653315
		BM128472 AW337972 AW515837
		AI669489 AW664176 AI768730 AW271660 T16381 AI823834 AJ346113 AI242353 BF437578 AI273673 AW513498
		AI797424 AI674242 AI277236
		AW731756 AA373089 AW207589 AW467879 AL550999 N30075 BE883669 BF155456 AI423079 R60281 T16974
		BG676892 BF927070
		BI962758 BE811485 BE811591 BE811702 BE811600 BE811483 BE811533 BF927061 BG008257 BF873368 AL574815
		BF946447 H70934
		BF939868 BF378761 BE082381 BG984527 AA244447 BG983567 AW885571 AW293182 AW885607 AA811057 AA610310
		AI434406 AA514352
		H71020 BF740351 BE814815 N66648 AA737686 AI025403 AA255490 N26754 AI094233 AA629548 AA716234 BF343632
		AW363633 H62663
		N40757 N55959 AW858569 AW604731 N40773 N40777 T83895 AI905899 BG007487 BF820299 R60231 R60787 AA456130
		AW383736
		H05232 R59374 H12223 AI935759 AI362553 D60006 N29572 AI916833 N75273 AA148710 BI597117 BG740471
		AA332671 AA333874
410365	60627_2	AL050199 AI872323 BE883872 AA424083 BG109354 AI243745 AA834941 AW102813 AW196535 AW973796
		AA559860 AI475291 AA559908
		R34681 H96211 Z39807 BF954386
417628	2137209_1	T84214 Z43709 R05654
434809	118540_1	AW974687 AA652145 AA649656
420985	455_7	X94703 NM_004249 AL521205 BF886672 N46403 T87420 Z36855 BF934259 BI549507 BG899191 BI517479
		BI818431 H39666
428104	1376802_1	AI205993 AA421350 AA421440
430933	605836_1	BG284105 BE080356 BF372738 BF372697 AA489179 AW863789 BE179901 BE179402 AW863635 BG995706 BE010747
421297	16064_1	AB033081 AK074324 AW450283 BM128413 BE550945 BE670081 BE674137 AI298087 N30050 BF110807 N30072
		AI288098 N30068
		AW861931 AW858575 AI363734 AK025483 BF882045 BM128581 AW771330 BE669540 NM_016376 AB037360
		AA399607 R94364 BE514643
		BG684040 BG759578 T83725 AW858561 AW858524 H65293 AW754345 AK025960 BM477612 BE071291 BF087041
		BG995615 BE071350
		AI917153 AA436381 BE815318 AK025717 BE857148 AI741138 AW027718 BI789162 AI492263 AI690072 AI420179
		BI789249 AI637804
		AW957459 BF222458 AI094328 AW510893 AW295994 AI760430 BE464934 BE220458 AI042022 AI653315 BM128472
		AW337972 AW515837
		AI669489 AW664176 AI768730 AW271660 T16381 AI823834 AJ346113 AI242353 BF437578 AI273673 AW513498
		AI797424 AI674242 AI277236
		AW731756 AA373089 AW207589 AW467879 AL550999 N30075 BE883669 BF155456 AI423079 R60281 T16974
		BG676892 BF927070
		BI962758 BE811485 BE811591 BE811702 BE811600 BE811483 BE811533 BF927061 BG008257 BF873368 AL574815
		BF946447 H70934
		BF939868 BF378761 BE082381 BG984527 AA244447 BG983567 AW885571 AW293182 AW885607 AA811057 AA610310
		AI434406 AA514352
		H71020 BF740351 BE814815 N66648 AA737686 AI025403 AA255490 N26754 AI094233 AA629548 AA716234
		BF343632 AW363633 H62663
		N40757 N55959 AW858569 AW604731 N40773 N40777 T83895 AI905899 BG007487 BF820299 R60231 R60787
		AA456130 AW383736
		BF087045 BG995619
410365	60627_2	AL050199 AI872323 BE883872 AA424083 BG109354 AI243745 AA834941 AW102813 AW196535 AW973796
		AA559860 AI475291 AA559908
		BE670565 AI919258 BI002664 AA557197 AI581597 AW604533 W69379 N66899 H84695 N53879 AA644631 H24627
455631	1488654_1	BE063040 BE063006 BE063031 BE063002 BE063072 BE063024 BE063008
432523	1031284_1	AW972205 AA551756 AW815357 AI023998 AW895029 AW856039 AW753791
440328	15103_5	BG203047 BG208248 BG211369 AW392243 AW392234 AW392226 AW392246
441229	591349_1	AW083064 AA923345 AI744267 AW517768
428023	MH1660_24	AK027255 BE856281 AW182584 AW027872 AI819831 AI936994 AI278611 AW338658 N29885 AA687514
		AI824306 AI038904 AI034339
		AI292064 AA973469 AI291616 AI079733 AI038683 AA491599 AA776023 BE813865 AA993675 AA837380 BF806738
		BF803246 AI087090
		BE930098 AA911116 AW137988 AI989393 AI283557 AW175908
424967	2139_1	BI116740 BM312146 H84589 BI831716 AW468329 W35384 W37216 BG818478 AI188435 BM311546 AI885302 BF448603
		AI870012 AI797830
		AI185731 AI336328 AI292299 AI240858 AW057899 AI970695 AI350388 AI292131 AA846185 AW665469 AW002306
		AI144304 AI306407
		AA465170 AI283059 AI026124 AA771949 AI038429 AA725179 AA846193 BE773021 AI201261 AI797645 BF593616
		AI245212 AI301420
		BE466901 AI203386 AW592346 AW748053 AA854554 BE719868 BG475523 W33173 BI019056 BI831085 BG005729
		AW075722 AI201542
415023	37164_1	BG763540 BI115604 BG325282 AY007096 BE048206 BE048060 AA356949 BG469451 BE267760 AI683752
		AI702004 BE247172 T47611
		T47612 BE780300 AA932146 AA652369 AI784281 BM055020 BM023299 AI382709 AA159351 BI262171
		AI863355 AI674922 AI754389
		AW295190 BE673083 AW469497 AI949042 AW131720 AI990060 AI623178 BE673420 AI863364 AA620354 BF431793
		AI056058 AI056059
		BI258269 BI823911 BG482172 BI261556 BI519838
437306	708160_1	AW977693 AW270552 AA748487 AA767827 AA827207 AA934962
452479	3144985_1	AI903527 AI903576 AI903573 AI903529 AI903528 AI903525
431675	135623_1	AA699965 AA513572 AI696381
432600	114582_1	AW973464 AI821831 AI821085 AA640756 AA657438 AA554802 AA650339
400271	893_1	BM467047 BI668430 AV723510 AA383564 BM466286 BI756033 BI752301 BE741302 AA312107 BF219348
		BF224233 AA372905 BE972765
		BG530510 BG430596 BG430439 D56385 BE566653 AI761953 AI361096 AW771495 T65962 BI494838 AW271309 AI423700
		AI762323 N72193
		AW007571 BC013873 X72964 NM_004344 BC008415 BC005334 AL554338 AL559625 AL559603 BG696707 AV733516
		BI670087 BI600577
		BI043582 BE866235 BE293715 AI681691 AA283060 AW612235 T29090 BE694176 Z30203 AA379970 W21362 BG179242
		AI681294 AI694310
		AI670881 AI074606 BF940039 AI858065 AI681393 AI991986 AI400174 AI910439 AI089029 BE048642 AW614075
		AW262850 AI431584
		BI495202 AA582224 BI495201 BF197587 AA459997 AA282970 AI769114 AA632011 AI091029 AI375169 AI400216
		AA782032 AW044700
		AI633913 AI129124 AI624690 AI799764 AA916363 BE503032 M492546 AA987867 AI373064 AW772272 AW015455
		AI368642 AW243721
		D45517 AI868673 C20558 AI130836 AI928680 AI191010 AA834469 AI963630 N93012 N67416 AL577079 BG532126
		AI640172 AI670873
		AI457787 AA460091 BE090147 AA614862 BE182933 AV733272 AI909822 BI494839 BG121897 BE293433 BI044033
		BF910106
418876	121279_1	AA740616 AA654854 AA229923
414783	262554_1	BE972667 AW069569 AI392889 H85161 AI074962 AA423935 BE671254 AA912627 H39845 H69083 AA280259
		N67746 AA155722
446841	127420_1	AW958927 AW002054 R00045 AA384616 AA669984 AI571663 BF439133 AA302636 AV660567 R02526 T90529
		AI678912 AI185622 AI963670
453929	97058_1	AA045461 AA284145 AI494193 AI469576 AV700262 BF222563 AW190054 AI263834 AA040074 AA045137
459436	880261_1	AI908449 AA323121
427224	25669_1	BC014914 AW025233 BG433378 AI348364 AA917746 AL135554 AA708134 AI095765 AI291861
		AI264632 AI032834
		BM464145 AW575013
		AI383072 AA815134 AA765181 D59880 H29890 AA825534 AI696290 M399405 BE669700 BF224225 AI914181 AI674625
		AI125811 AI022371
		N63064 R93084 AW977125 BE568027 BG434014 AA403200 AF062366 AW891180 AA401207 AA477849
		BE764638 BE764629 AW891194 AW439069 AW891199
442484	3699_10	AI110863 AF075362 AI110861 AF075360
418831	245538_1	AA488082 AA228970 AA230043
448079	74377_1	AK054894 AW978550 AI984051 AW205843 AW205839 AI379941 AI383948 AW129532 BF197455 AI954133
		AI668869 AI360826 AW614392
		AI619505 AA927599 R64287 AI803003 AI675123 AW023079 AI638324 AW134959 AA831069 BE772132 F29901
		BF210719 AI376624
		AW960171 AI275045 BE856533 AW243724 AI051487 R68631 C17731 Z44230 AA309094 BI837972 AA122297 BE929614
		BE006483 AA098802
		BG252168 BG928816 BI091300 AW963375 AA213871 BE925757 T90131 BG426009 BG611801 BE090425 BF672863
		BF132610 BF184312
450869	2827_1	AK074246 AB062418 AI040384 AA694057 BG566618 R83450 AA011459 H57230 H93947 AA033972 N91333
		AI040705 AA705512 H57154
		R05747 H66758 T97233 H61474 AA033971
437406	5564_1	AL355708 AL390182 AW961056 AW026094 AI201896 AI339096 AW753013 AW377575 AL359597 AA458509
		AA101706 AA430395 BE218599
		AI580153 AI337252 AW672987 AW117483 BF477914 AI159869 AI469834 BE328727 AI800118 AI049995 AI739268
		W40584 AI695716
		AW008980 AI689764 AI393298 AW139228 AI097595 AI762231 AA454591 BE219638 AI291020 BG149193 AI769982
		AW189752 AI418017
		AI363808 AI926110 AW590852 AI524293 AI424269 D30993 AI669931 AW873757 AA355695 AI392826 AU147571
		AU154893 AI685419
		BE326844 AW024382 AI271608 BE856703 AI739564 AI588871 BF437288 D55501 AW883430 AI991167
		AI681404 AA534707 W78925 AI547249
		W85910 AA702573 AA677590 AA971286 AA452238 AA582421 AA262979 AI023007 AI038705 AA977918 AA454590
		AA973696 AI091861
		N66679 R39883 AA868049 AA846818 AA150827 AA151064 AA101707 N50264 N49212 H05824 BF856686 T26533
		AI983044 AA730190
		BE856310 AA009812 N20978 AA009813 T26532 T07386 AI084242 Z38902 AA904453 T78860 H84638
458172	363900_1	BE007237 BE546311 AA984819 BI256810 W19919 BE007263 BG000322 BF327011 AA890198 BE007496
414992	1785181_1	D63302 D78793 C17962
410215	15479_2	BI914830 BG209254 AI694353 AI312853 BF593037 AI088624 AW340577 AW015288 BF589940 BF222096
		BF431760 AA781252 AA449828
		BF436265 AI572104 AI695710 AI627770 AI524498 AW662141 AI572181 AA988863 AA782797 BI766911
411115	1070123_1	AW818312 AW818453 AW818380 AW818207 AW818214 BF375509 AW862010
407604	43771_1	AK074129 AL138071 AI806793 AI453544 AI084616 BF062435 BE672932 AI828296 BF062464 AI803443
		AI264326 AI280956 AI743547
		AW295227 AW139967 AI972561 AI863570 AW062752 AW062756 AW062753 AW176904 AW062755 AW062750
		AW062749 AW176886
		AI751694 BG251391 AA043621 W30872 BI524827 N94581 AI084614 AA776976 AI377572 AI751695 AI016576
		AW439994 AW194255
		AW627763 AA668249 AI079870 AW022524 AI968540 AI248360 AA702490 AA043262 AA631511 AW176883 AW751767
		AW176887 AW062748
		AW062745 AW176862 AW176815 AW176814 AW176846 AW176841 AW176871 AW176874 AW176819
		AI927437 AW191962 R36548 AA853713
		AW196059 AA618567 AW176881 AW062754 AW062751 AW062746 AW176888 AW751772 AW176859
		AW751765 AW751762 AW176833
		AW176873 AW751745 AA694513 AA780815 AW176857 AW176834 AW176839 AW751771 AW176878
		AW176843 AW176842 AW751755
		AW176847 AW176812 AW176830 AW176849 AW176844 AW176877 AW751757 AW176850 AW176851
		AW751758 AW751746 AW176858
		AW176853 AW751766 AW176845 AW176872 AW176840 AW176876 AW176852 AW751754 AW176836
		AW176856 AW751773 AW751760
		AW751751 AL138070 AA639738 AL602588 AA853712 AA317570 R38469 AW291569
452780	73430_3	BF576403 N79410 AA028160 BE171598 BF090519
458311	2694866_1	AF069480 AF069479 AF069478
413533	12274_1	AK055111 BI560412 BI600640 BI549250 BI463611 BG898612 BE468008
		BG675527 BE146768 BF853416 BE146973 BE146972 BE146767
		BE146985 BE147021 BE147018 BE146793 BE146783 BE147020 BE146760 BE146954 BE146771 BE147044
		BE146766 BE146952 BE146776
		BE147048 AI686856 BE147042 BE147019 BE147025 BE146797 BE146781 BE147030 BG420528 AW294469
		AW248308 D29070 BG152458 AA908606
446501	2873469_1	AI308174 AI307311 AI302616
450371	1627928_1	AI694038 BE464839 AI803494 BE241794 H86709 R34926 BE241681
414496	1526_1	AK058006 BF724822 W65303 AW887764 AW023806 Z25353 AW022095 AA730973 W00417 W73819 BF982096
		AI927669 AW188021
		AW770478 AI913512 AA604358 AI697341 AI691028 AI338392 AI079403 H97538 AI144448 AI253102 AI051402 AI335900
		AI868132 N28900
		H98465 AF268386 AI799915 AI819228 BE048413 AW304723 AI819923 BF223106 AA155907 AW298079
		BF055272 BF446804 BF197697
		W58588 BF197538 AA032180 AA992597 AW590254 AA027824 AI129369 AI131331 AI655843 AA932907 AW104493
		AI150615 BF110226
		AW172271 AI312659 M057312 BE673669 AA722984 AW104985 AI129232 AI078648 AI653086 AI703481 AW515897
		AI352206 N67076
		AW297281 AI686162 AA029184 AI610743 AW772016 AI091778 W65401 AI687374 AI218085 AI765158 AI018002
		AI653068 AI335704 AI520850
		AW275228 AW275204 AI420247 AA975336 AI697042 AW182235 AA736386 AI281682 AW169698 AW263325 BE645834
		AI377438 AI146706
		AA613808 AA716538 BI496247 AA032248 AI698930 AI193399 N70026 H86792 AA404489 W61267 BF447230 AA910805
		AA150774 AA621907
		AA902526 AI827634 AW022037 BF059000 BI496246 BG577007 BG571077 AA460779 AW816890 AW816893 AW816891
		AA029183 AA010295
		H86850 T83320 BE160823 H12925 N40087 AA096372 BE160847 AW816892 AW816889 AW816882 AW816868 AW816941
		AW816578
		AW816940 AW816577 AI431628 AI828113 AA033677 AA033654 AA452704 AA317582 AA346971 BF836584 H48669
		BI861605 BG925200
		AA463277 H89048 AA155952 W03252 W01510 W00915 W58589 AA164519 N24017 N24622 N27149 N70109 R43771
		AA010296 W84611
		H98889 H88965 AW594424 AA034139 AA065223 N99696 BG981481 N94371 AA767970 W47146 N70977 H05510 W61268
		T90796 AA164518
		W47244 AA150883 AA034138 BF338483 F13671 H51317 W72716 N21488 AI188071 AI370541 AI754442 AA148524
		AI749182 W95221 W92522
		R20385
455100	1096250_1	BE160198 AW935930 AW856073 AW861034 AW935898 T11520
411806	1107840_1	AW864356 AW864547 AW864277 AW864496
432676	3503_22	AI187366 AA618478 AA558869
422642	873508_1	AW961201 AA314041 D63247 C18669
432377	1620366_1	AA535140 AA534670 AA535021
445298	724820_1	AW295700 AI219199
446868	15525_1	AK074473 BC017997 BI831060 BF971101 AI886394 AI082824 AV708785 W86073 W07772 AV660737 AI816793
		R52250 BG183529 AA633473
		AI191256 R44763 R19947 BF571346 W86257
425199	1276656_1	R97184 H47493 AA352099
437714	845454_1	AW977404 AA836116 AA766346 AA809877 AW469598
426143	3806_1	BC005265 BG176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 AI092211 BI492387
		AI400449 AW166297 BF939910
		AA232282 AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 AI092748 AA993184 AI126077
		AI081758 AI240686
		AI261863 AI378423 AA465237 AI376096 AA035579 AI087306 AA448162 AA129977 AI090903 AI080686 AI288939
		N33004 AI801240 AW021546
		AI370773 AI086064 AA669528 AI250053 AI870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283
		AW467587 H40506
		D00762 NM_002788 AA641134 AI582295 AI417525 AI563975 AI093566 AI707743 AI290741 AW073417
		BE875418 BM264076 BG876884
		AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569
		BG878291
		BG876450 AW819099 AI908570 AA449871 AU135228 BM478404 BF126296 AA375499 AA248473
410388	36281_5	AW386165 AA831460 AA772198 AA687734 AI469486 Z39019 AI829314 AI809944 AI969600 BE348981 AW439586
		AI207192 AI307374 AA084590 AA738148 AA309799 H89072
442107	2684347_1	AI912225 AI692286 AA976601
452299	89203_1	BE221822 AA025352 H43596 AI452797 AW206330 BF824812 BF748930 AA025363 BF856465
440248	2616908_1	AA876138 AI239602 AI698953
433023	3970_8	BE999967 BF438599 AW864793 AI802899 BE815132 AW468888 AI672189 AI052004 BF112024 AA772335 AW275054
		AA573845 AI144148
		AI968683 AA846676 AA927355 H80424 AW973295 R88209 F29868 BE928871
453085	10017_1	BC017336 BG716430 BG501286 BI458528 AI582223 N98532 AI338138 AI273442 AW102617 AA831177
		AA745642 AA412583 AA355375
		BG547492 AW954243 BI766546 BG057641 AI192435 AI338935 AI312651 AI708679 AI191125 AI206832 AA676899
		AI078010 AI888718
		AA452830 BF445542 N69930 AA715017 BF446713 BE046852 AW771909 AA907729 AI143749 AI761290 AA890233
		BF925759 AI783713
		AI767267 AA814538 W56778 AA918481 BG743526 BE645242 AI025328 AI298436 AI290445 H27710 AI475034 BG740023
		AI090348 AI340003
		BI602481 W38495 AI183314 AI927418 BG397181 AA878310 W19369 W56507 C05751 AW380760 AW380770 AW380790
		BF930729 H28425 AA037326 AA375805
432541	625908_1	AW973316 AA552525 AW131368 AA614350
409193	22239_1	BC014317 BC015099 AF229179 NM_020665 BI760941 BG427247 BG429705 BG432624 BG399046
		BG430790 BF940314 AW242855 AI793025
		BE048959 BF589928 AA999850 AI767568 AW612416 AI911520 AI793193 AI373739 AI985237 AI433883 AW779364
		AI253234 AI478325
		AI524824 AI613056 AI650909 AW299600 BE465778 BF431418 AI470468 AA345162 AI671437 AI473091 BE501448
		AI431850 BG400513
		BG429618 BG400845 BG429174 BG429011 BG400319 BG399402 BG427839 BG433974 BG428217 BG426067 BG428990
		BI762437 BG209271
		AV653898 BG188580 BG400436 AI765078 BG184374 BG193796 BG431368 AA131483 AA065156 AA076448 BF031348
458140	1648556_1	BE559806 R12767 BE268806
445208	2826769_1	AI681579 AI216103 AI692734
458799	643053_1	AW173151 AI688547 AI768659 AI476487 AI797300
420820	26124_3	W73822 AI686053 T10508 AA722451 BF750857 BI858823 BF964200 AL577848 W26760
		W73854 AA476662 AA280705 W26998 W27144
426532	1297511_1	AA486726 AA380886 AA486725
434072	73667_1	AF116655 AI114499 BF760333 H70853 BF326768 H70854
455063	1094851_1	AW854160 AW854156 AW854149 AW854147 AW854158
406827	0_0	AA971409
400157	2764_1	BC022339 BC009610 BC010537 X79805 NM_006713 U12979 BM467814 BM450743 AU132951
		AU137129 BG493425 AV758819 BG708412
		BG705885 BG702217 AV716638 BG777009 BI545689 BI552153 BM476712 BG770858 BG527656 BG528277 BG391388
		AV716861 BI602926
		BG290073 BI667399 BM451469 BI667173 BI602139 BG532171 BI669216 BI544727 BG721852 AV716503 AV701327
		BM090738 BI492000
		AI308856 BI544904 AL599813 AV715829 AV716505 AV714587 AV717902 BF668072 AV716385 BI461927 BM090954
		AV717826 BG503676
		AV647719 BG501392 BG428433 BE895629 BM313117 AW021050 BG435032 BM152910 AA313503 AA872377 BG574714
		AV712054 AV732696
		AA252476 AV712759 AL599643 BE790872 BG654930 W73337 AW675377 AV760376 AV725139 AV716379 AA887165
		BE830003 AW023796
		AL599291 AI902948 BG944042 F00781 AA352483 BG217897 N33888 AW581924 BG654730 D31410 AA353088 D31288
		AA295029 H95170
		BE935104 AU139980 BG772963 BG776470 BG532512 BG105449 BI545421 AV715456 AW386083 BG699714 AL535832
		AL514940 BG190861
		BG210593 AW999254 H95138 AA353863 BE764809 N50375 BE091363 BG701255 BI860846 BI832485 BG168150
		BG028647 BE546301
		BG900321 BI909737 BG702363 BG614141 BG611137 BG700121 BF031492 N85802 AV715940 N51590 BG993478
		BE172016 AW893622
449261	3029652_1	AI923721 AI860294 AI637592
434636	15423_1	AJ420454 AF147430 AA910497 BF432963 AI701451 AI743089 AA429326 AI887812 AA315932 AI005464 AL043321
		AI300993 AA425105
		BE467230 BE669770 AA885637 BE503044 AW014324 AI809584 AW167510 AA921331 AA903224 W01644 AI762128
		AA031404 BE550653
		AI694045 BE043088 BE670430 AI630969 AI457315 BE644737 BE327316 AW295247 N92784 AI630807 BE328180
		AI269949 AW245292
		AA083765 AA256898 AI375535 AA430673 AI168735 AI589717 AA015942 AI693885 AW341205 AA931651 BF856764
		BE468094 BF433393
		BF445511 AA928976 AI817684 BF111008 AA428316 AA455858 N25716 AA568727 AI581817 AA427482 H40678
		AA041483 N71630 H51826
		BF969052 AA094470 AI560352 T98937 W52816 AA083764
413186	10095_1	AI800480 AI675873 AI492036 AA285369 AA043133 AI565092 AI094934 AI127591 AA774663 AW262141
		AW184007 AI423287 AI282115
		AI309111 AA206116 AI984711 AI218432 AA565473 AW439256 AI915825 AI690350 AI867581 AA888739 AW135142
		BG202056 Z39676 T16640
		AA765047 AW020940 AI961664 AI636487 AA492375 BF511091 BF511214 AI129459 AW117212 AI968323 AI656300
		BE503348 BE503313
		AI361209 AI925328 AA968416 AW611654 AW614387 BG108803 AA029159 BF176324 R16207 AL567126 AA224460
		BM145135 BE855388
		BI491899 BI493821 AL581038 R49543 AA422156 H92081 AA325525 R66331 BF748472 AI990318 AA279568 R67472
		R32365 AI361184 R66332
		AA029056 BE738339 BM145028 D29452 BE619671 R80926 AA130505 AW271168
417890	6087_3	NM_003777 AJ320497 BF980177 AA489276 AI042319 BF881839 BG999412 BI003305
		W31815 AJ132087 BF369731 BG186912 AI740921
		AI453059 AI027448 AI027859 AI041705 AI087934 BF056332 BF109708 AA937198 W20023 R23111 R79048 N90533
453823	1489490_1	AL137967 BE064160 BE064186
436763	1050498_1	BG928040 AI095270 AI990086 AI991608 AA730741 AA868238 BE815056 BE550792 AI168278 AI522194 AA973538
		AI628424 BE814976 AI819707
446002	2852062_1	AI346468 AI347958 AI269775 AI269780
409835	915194_1	AW501362 AW501275
411111	1070063_1	AW818161 R09719 AW818127
408594	685806_1	BE184942 BE184946 AW238414 BE144666
433361	25962_1	AF026526 BG210339 AW611839 AI333926 AI719252 AI478251 AW469373 AI678201 BF056830 BE552206 AA706678
		AW594061 AI744564
		AI025408 AI744629 AI033875 AI051333 BF438997 AI991433
442079	648638_1	AL046653 AW183787 AA977613 AA975487 AI051504
443274	33097_1	AK023535 BI850449 BI494019 BG113829 BI494020 BF378857 AW262721 AI339175 AW029243 AI417477 AI679401
		AI083840 BF475695
		F26528 AI679908 AA659612 AI453737 AI523378 AW630773 AA251578 AA658039 R72090 AI832404 AV693821
		AV698231 AV685465
		BM423386 R80276 W39196 BI258049 AA508602 T85159 AA156499 AA664240 BF212163 AU156501
413840	38807_1	BC020284 AW953495 AW402677 BF890739 Z44378 AI660081 AI769242 T84954 C05886 AI224851 AI568340 AI024026
		AW015010 AI032051
		AA505095 AA830304 H98001 H63431 BG249610 AI284792 AA205732 AI598130 AW516813 AI123905
		AA132557 AI140199
		H53399 AA928496
		AI200299 AI400044 BE940512 BE940609 H28028 BF913868 AI301558 D79095 AI762695 AA311547 AI673408
		AI673002 N67358 AA885913
		AI288094 N67347 Z40311 T94918 AV722693 AW170339 AW975566 AA452774 AA504759 AA370643 T79706 AA721603
		BF858887 BG982917
		AI343373 AW236167 BE568091 BF747959 BF241262 BE940663 AI435278 R05794 AW027091 AI860259 AI268890
		T94871 AW182884 N67183
		AW149083 H42473 AI678254 R26706 AI419684 R24905 AW388568 AW363261 N31299 H63489 AW195475 AA452592
		BE844216 T91205
		H64955 BF858811 AW962779 AW388295 BF857615 BF856552 BF856548 BF857611 AW866752
430715	32242_1	AI148194
450234	707416_1	AI797978 AI688524 AW270069
454514	1058176_1	AW802838 BE170861
449540	79180_1	AA001803 H63836 AA001713 H63784
444156	7612_13	BM456075 AA287437 AW503282 AW500236 AW505532 BM476391 BM151675 AW500059 AW503519
		AW505387 AV760244 BM463484
		AW499930 AW499907 AW504121 AW504494 AA286674 AI276686 AA286673 AW407901 AW503798 BG177295
		BG389213 BM145086
454552	1061234_1	AW806924 AW866478 AW866473 AW866390 AW866309 BF373982 AW866298 AW866539 AW866521 AW866547
		AW866454 AW866537
		AW866517 BF373957 BF373949 AW866403 AW866369
417414	10043_1	AB049113 U31930 NM_001948 U90223 AK000629 BI091680 BG697899 BG700386 BE644721 BE673841 BE670064
		BE218639 AW160384
		BI489866 AW341118 AW629827 AI697600 BE222283 BF938984 BE550008 BF058963 BE549576 BE504213 AI951891
		BG654389 AW162006
		BE551158 BG655751 BI438412 AI634515 AW967946 AI373097 AI937879 BF477872 AI693247 AA284034
		AW968574 AW968748 AL519489
		AA491130 M89913 BG403290 M504296 AA263067 AA366402 BF899218 AW007239 AU119115 D55898 BI333317
		AI879028 AV651114
		BE502892 AW341323 BF478012 BG705392 BG505144 AV747151 AA416647 W65362 BF170355 AI361859 AI061446
		AA744361 AI800124
		AI888707 AI810305 AW950219 AI266370 AI202472 AA731309 AI352257 BE327789 D19871 AW059539 BM263848
		AI828180 AA994216
		AA721362 R76541 AA806886 AA861025 AA687747 AI304562 BI091131 BF206146 BI255334 BE254729 BG610639
		AA278989 BF698002
		AA446533 BF970255 BE928140 AI348028 AI521455 AW474561 AW591403 AI654314 AV701730 AI433388 AW166689
		AW976899 BE568767
		AA887905 AA766415 BG168154 BF317403 BI855761 BI758597 BF216176
453959	9900_1	NA
439195	21979_1	AF086037 H89360 H89546
400223	2368_1	NM_005648 BC013809 L34587 BF103775 BG702618 BG716553 BI667090 BG505863
		BF983483 BG718195 BI857891 BG501016 BM043599
		AL521812 BG705730 BI495545 BI495546 BF112248 BM023182 BM023123 AI075173 AW051799 BF058224
		BI324885 BF436008 AA398446
		BG822375 BM019558 BM023382 BG164174 N56909 BI467064 BM023464 AI207475 BM311415 BG758430 BG758807
		AI934826 N90351
		BG422026 BE910312 AI027778 AI081950 AI360890 BM009115 AI191829 BG759697 AI138728 AA399403 AI355589
		AI336427 AA868702
		AA393660 AA025127 BG027630 AA962774 AA631224 BG940967 BE791087 AA573315 W81685 AA393525 BG944103
		AI339125 AI149864
		AA977655 N90314 BE612839 BG491847 AI129091 AA461234 AA781198 AA759256 AA888954 AA975844 AI184099
		AI018025 AA398363
		AI003331 AI193380 AA626020 AI244476 AI601114 AW135664 AI206607 AW263599 AA813219 AI684453 AA878626
		AA772222 AI085496
		AI630226 BG940966 AI022010 AA770649 AA887624 AA491739 AA974295 BG530040 AA037091 AA019912 BI160457
		H64512 BG503896
454067	98108_1	AI809849 AW241782 AA041455
442092	22756_2	BM449821 BM069895 BM023170 AW025563 BG152606 BM023452 AI862106 BG959957
430504	5477_6	BE219720 BF475241 AI571723 BE219848 BI789268 AI224899 AA724864 AW771467 AA480255 AW845616
		AI440295 H52800 BE218790
		AI681575 AW300064 AW262133 H21568 AI363015 AI884914 H86948
406731	0_0	AI559131
457447	44331_1	X78261 AI214094 AA483530 AW972127
455679	151610_1	BG007296 BF330853 BF747375 BE066356 BE066292 BF330900 BF747142 BE066419 BF742510 BE066529
		BE066298 BF742516 BF746603
		BE066274 BF334312
430534	1233361_1	AW968508 AA480908 AA480971
409490	2925095_1	AA084745 AA084736 AA075064
425376	34867_1	AB075838 AK056181 AW958603 BE390381 AA356365 BF196303 H10404 Z39522 AV725320 AV727868 BM454236
		AA365277 R38602 H10612
		BF212958 AA481673 R13757 BG026236 AI498819 AA894612 AA610077 AW352149 AA481433 AW079577 AI885666
		AA532463 AI624958
		AI624974 H93131 BE566327 AI955749 AI478116 BE546266
437440	2497201_1	AA846804 AA757581 AI050950 AI092024 AA838807
453327	23886_2	AL562496 BF696621 AV704702 BG898086 AW968374 AA481612 AA431838 AA476509 BM271915 BI438471 AW021944
		AA465428 BI492903
		AW500180 AI337886 AW628927 AI337904 AI865657 AI095827 AI277333 AI192671 M910864 AI056123 AI359717
		AI801670 AA554891
		BF002895 AI146699 AI277967 AI421245 AI554684 AI076969 AA127232 AI090547 AW295617 AI339523 AI144431
		AA857201 AA476409
		AA465393 BF445672 AI247616 AA905002 AA723681 AA465357 AA465372 AI027015 BF939274 BE769036 AA983718
		AI796838 BF373700
		AW864097 AA506221 BE326573 AW368726 AA035002 AA149487 BE887617 AI692779 AI183608 AA858044 BI467397
		AA046036 W67790
		W32699 AA431436 AA035510 AA836772 AA481546 BM264551 AA465448 AA339752 BF698980 AA621703 BE825936
		W67848 BE766805
		N66434 N59817 N26170 AA668310 BE768929
428384	775_1	M54968 AA861543 AA356548 AI469981 NM_004985 BC013572 AW242010 AI740449 BF588730 AA425263
		W21091 AI554920 T28976
		AW966530 BC010502 BM146110 AW504574 BG142117 AA232870 AI539465 AU123937 BI260541 BG261289 N24354
		N32462 H08297 F05452
		AA281203 N80109 AA330460 D51551 BE178107 BE177839 BE178094 BE178141 BE931948 BE178093 BE178215
		AL138354 AI091259
		AW020801 AA287991 BE178352 AA281183 BE178186 R70669 BI833742 BE178449 BE178043 W47526 BE178018
		BE834453 W93668
		BE177936 AL576273 AU151852 AI004579 AW453052 AA287927 BM144801 AU155143 AA281094 AA737010 AA872481
		AA676681 AA843916
		AI697660 AA564243 BF109372 AI015987 BF432094 AA937541 AI334416 AI281159 AA582189 AA553559 AW160515
		AA255527 AA670007
		AA808271 AA281015 AA649252 BE464958 AW167917 BF436494 AA525301 AI889481 AI364302 AW173466 AI676214
		AA243624 AA648116
		AA854442 AA721296 F01713 BE178360 BE178299 BE178460 BE178385 BE178424 AI301629 BE049265 AU151277
		AU155121 AU155337
		AA889246 AU153181 AA342730 AW601642 H08199 R41588 R99351 H84241 W47527 R26447 R49696 H02312 R79833
		AV716970 AA262387
		BE178441 BE178356 BE178100 BI491761 BE178467 BE931952 BF758698 BE177893 BE178336 AA256711 W80934
		BE178447 AV689618
		BE178438 BE177844 AV659669 BG619554 AU134516 R35396 BE178029 R28455 AW368425 BE178017 BE177999
		R34165 R79640 BE178422
		BF761849 BE178196 BE178443
426295	510_1	BE880923 BG390191 AW470082 AW014585 AI423255 BI714731 BG054894 AW780248 N31683 AW664132
		AW467353 AI983152 AA617918
		BF447795 AI088357 AA807328 AA576970 AI741153 AI755003 AI474016 AI422030 AI348114 AW997085 BM271753
		AI363147 BM311311
		AI146640 AI246771 AW512619 AI359020 BG054897 AI292234 AI215830 AI283836 C06205 AW503423 AW272680
		N33205 AW873021
		AA070724 AI753886 AW192487 AI087151 AA658909 AI346368 AI335677 AA825442 AW440066 AW131357 AW513210
		AI082314 AI085455
		BE551404 AA780704 AW008596 AI796964 AA917471 AI400531 AA668626 N72207 AI306482 AW440562 AI084687
		AA347280 AA063536
		BF477389 AI241662 AA931543 AA484310 AA812486 AI032216 AA665779 AI916336 AI350590 BF198106 AI433377
		AI300638 AI672626
		AI282741 AI351487 AW105544 AA973627 AW517914 AA715424 AA508454 BF334080 AI274618 AW367201 AW572619
		AW469088 AA382095
		AI368364 AI146934 AI357180 AI361181 BI911347 BI871044 AA136325 BF084010 BF084007 AA335788 AI920878
		AA809614 BE932941
		AI678261 C75308 AI148479 BE178174 W88513 BM013627
436024	138548_1	AI800041 AA703553 AA984529
419881	3973_1	AL573520 BF058611 AA329340 AL578426 AA748587 AA251524 BG056795 AA989242 AA716558 BI860141
		AW967619 AI949529 AI889732
		AI871690 AA830473 AA769808 AA570708 AA844702 AA838659 AI653883 AW768563 AA442846 AW273448 AA437017
		AI493986 AW628781
		AL562775 AI870399 AI432295 AW439601
414022	32320_46	W44916 F07627
415524	1875412_1	R13958 Z45262 F11541
459428	259201_1	AW502680 AA258989
412634	131633_1	U55984 AA195883 AA447957 AA393452 AA384799 AW958952 W68044 AA197345 AI241933
		R59505 W67965 AA826474 AI336006 AA931733
		AW025414 AI769180 AI355738 AI860952 AA907417 AW408679 AA453139 AA938346 AI279697 AA121899 AA400768
		AI559827 AA448889
		N62400 AW236656 AA904207 W79380 R59504
416721	1987834_1	H80001 H87290
454900	1077113_1	AW838132 AW838129 AW838458 AW838513 AW838430 AW838373
442462	1984399_1	AF031405 H73415
434665	115504_1	AA642125 BG311079 BG311075 AA654516 BG311138 BG311173
400239	16458_1	BC003160 NM_001610 X12548 BG386685 BI760866 BI559619 BG323829 AU135543 BI834101 AU142120
		AU124511 AU124889 AL558171
		AU117286 BI824000 BG386610 BI753285 BI223475 AU134828 BM126369 BE206493 BF751498 AL544274 AY007137
		BI828921 BE870130
		BF771242 BI835451 BI765655 BI820955 BI223344 BG015924 BI759894 AL527413 BF310588 N31870 N23974 BE514914
		T48863 AW860257
		BF334625 AA883860 AU144168 AA442562 AU159491 AU148353 AA564123 AU148667 AI377256 AW664004 AI871712
		AI141486 AI332351
		AI339094 BE206109 AW519033 AI817729 AI332490 AI149455 AI857411 AI763154 AI751608 AI377222 AI081956
		AW664229 AI275872
		AW168546 AA975270 AI367408 AI687729 AI269164 AW105344 BM193081 BE550930 AI082116 AA854691 AI056249
		AI221062 AI290113
		D51818 AA732409 BG055125 N85878 AU156121 BF093671 AA053070 T28548 AL570460 BI006862 BI007207 AA373620
		W95069 AA629136
		AA708164 AI014886 AW168697 D51623 AA577168 AI094208 AA028946 AA975078 R16815 BG151132 AI276297 D51676
455148	1099439_1	AW858423 AW858403 AW858594 AW858406 AW858587 AW858549
434775	118125_1	AA648983 AA741088 AW029205 AI925642 AA715292
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0367]

TABLE 11C
Pkey	Ref	Strand	Nt_position
402994	2996643	Minus	4727-4969
402264	3289984	Plus	184006-185825
402424	9796344	Minus	64925-65073
404649	9796926	Minus	100027-100399
405533	9755498	Minus	75690-75853
402230	9966312	Minus	29782-29932
400751	7331445	Minus	35395-35533
400694	8118802	Plus	94288-94442
401467	6682292	Minus	66845-67037
403789	8084957	Minus	64056-64148, 65262-65425
406117	9142932	Plus	54304-54584
406420	9256411	Plus	157797-158054
404426	7407959	Plus	77842-77954
401274	8954206	Minus	111258-111378
400929	7651921	Minus	122033-122241, 123483-124028
403790	8084957	Minus	87826-87947, 89835-90002
405268	4156151	Minus	24404-24521
402855	9662953	Minus	59763-59909
400517	9796686	Minus	49996-50346
402976	9795206	Minus	25819-25969
403743	7652003	Minus	136463-136646
403828	9838214	Plus	31755-32148
405689	4508117	Minus	92558-92698, 94282-94382,
			97977-98180, 9920
403742	7212067	Plus	84805-85525, 91096-91227,
			93970-94057, 9523
403319	8318526	Plus	124240-124459, 125182-125409
404602	8705107	Minus	138628-138893
403654	8736093	Minus	28634-28758
402396	1905896	Plus	4426-4648
405372	2078459	Minus	10148-10272, 11205-11349,
			11436-11560, 1178
403694	7107765	Plus	142925-143080,
			165505-166186, 167486-16763
404584	9857511	Plus	138651-139153
404240	5002624	Minus	116132-116407, 116653-116922
404409	7342122	Plus	22113-22290
405601	5815493	Minus	147835-147935, 149220-149299
404919	7341872	Plus	1482-1609
403738	7212067	Plus	38434-38562, 56876-57007,
			59789-59876, 6071
401847	7139731	Plus	85447-85593
401928	3873182	Plus	54932-55070
406274	7543787	Plus	932-1123
401558	7139678	Plus	103510-104090
403746	7652036	Plus	93612-93887
402945	9368458	Minus	100591-100710
400487	8919452	Plus	19369-20782
403330	8516153	Plus	116558-116698
400975	7139779	Minus	108473-108847
400552	9801071	Plus	93101-93276
403147	9799812	Plus	171145-171419
406605	8272666	Minus	23275-23493, 23723-23903
402907	6706902	Minus	8561-8692
401431	8217913	Plus	81467-81661
401047	6705887	Minus	4804-5035, 5133-5314
404813	3355600	Plus	2672-2989
406137	9166422	Minus	30487-31058
400763	8131616	Minus	35537-35784
403608	8308266	Minus	121321-121476
400840	9188586	Plus	113882-114121
403827	9838214	Minus	14941-15869
403809	8568861	Plus	33910-34129, 34583-34862
403142	9444521	Plus	89286-90131
402813	6714723	Minus	45613-45781, 47581-47731,
			49698-49805, 5095
403538	8077008	Minus	119579-119926, 120614-120784
402969	9581784	Minus	19036-19175
406182	5923650	Minus	28256-28935
406364	9256114	Minus	50715-50833
405232	7249042	Plus	125904-126063
403417	6862691	Plus	199375-199572
405257	7329310	Plus	73121-73273
403585	8101208	Minus	131266-131769
403832	2121307	Plus	76091-77344
402964	9581599	Minus	46624-46784
401060	8117674	Minus	110262-110791
406350	9256015	Minus	186117-186362, 190904-191095
403056	8954178	Plus	95479-95570, 96434-96703
406341	9255965	Minus	117712-117896
404694	9799957	Minus	128092-128227
402668	7283250	Plus	67493-68044
405296	3779036	Plus	8072-8273
402729	9211639	Plus	78980-79093, 79333-79467,
			80173-80290
405122	8137462	Minus	95449-95646
402737	9212184	Minus	13358-13552
404231	8218035	Minus	61077-61322
405287	3928029	Plus	89802-89999
405695	4309958	Plus	51860-52162
401112	9966198	Minus	60628-61041
403671	7272159	Plus	104461-104701
400886	9958187	Plus	70649-71114
402474	7547175	Minus	53526-53628, 55755-55920,
			57530-57757
405064	7658416	Plus	81207-81416
402007	7381786	Plus	143964-144081
400967	7770682	Minus	32697-32999
404497	8151650	Minus	593-1416
404692	9799952	Plus	49258-49403, 54226-54341,
			63837-63988
405166	9966302	Plus	40526-40891
405270	4156145	Minus	3952-4123, 6886-7010, 8541-8728
402109	8131678	Minus	171722-171859, 173197-173303
403363	8571785	Plus	67156-67285, 67620-68007
406023	8272661	Plus	205623-205936
403185	9838287	Minus	108676-108803
403611	8347965	Minus	130635-130774
403707	7108128	Minus	132794-133294
404124	9796734	Plus	13539-14192
403292	7230870	Plus	99123-99367
403027	7670575	Plus	60696-60932, 61362-61521
406535	7711477	Plus	83135-83362
405922	6758795	Plus	126307-126677
406238	7417725	Plus	31155-31657
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0368] Table 12A lists about 254 genes down-regulated in Hepatitis C positive liver tissues compared to Hepatitis C negative liver tissues. These genes have the potential to be diagnostics and/or prognostic markers for Hepatitis C infected liver tissues. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the t-test p-value between the Hepatitis C positive liver tissues group and the Hepatitis C negative liver tissues was less than 0.01, and that the differences between the average “standardized values” of the several different Hepatitis C negative liver tissues was equal to or above 1.0 more than the average “standardized values” of the several different Hepatitis C positive liver tissues. The “standardized values” of the Hepatitis C liver tissues were derived by subtracting the median of the Hepatitis C negative liver tissue values from each probeset value, then divided by the interquantile range (IQR) of the same Hepatitis C negative liver tissue values.

TABLE 12A
Pkey	ExAccn	UniGene	Unigene Title	R1	R2
441475	AI929602	Hs. 177	phosphatidylinositol glycan, class H	6.80E−05	9.91
453863	X02544	Hs. 572	orosomucoid 1	1.46E−03	5.21
449761	AB009698	Hs. 23965	solute carrier family 22 (organic anion	2.10E−03	4.68
445610	AI831648	Hs. 143993	ESTs	1.53E−03	4.63
404473			ENSP00000247423: D-siglec precursor.	3.16E−03	4.40
440721	AW183540	Hs. 85273	ESTs	9.60E−05	4.14
442820	AW293459	Hs. 6314	ESTs	1.50E−05	4.04
446221	AI744445	Hs. 167073	Homo sapiens cDNA FLJ13047 fis, clone NT	7.92E−05	3.41
449184	AW296295	Hs. 196491	ESTs	5.21E−10	3.23
454947	AW846590		gb: QV0-CT0180-011099-025-d07 CT0180 Homo	1.84E−06	3.21
434180	AA921757	Hs. 116180	ESTs	7.08E−07	3.01
423744	D26158	Hs. 1701	ELAV (embryonic lethal, abnormal vision,	2.94E−03	3.00
410482	AW772187	Hs. 191859	ESTs	7.60E−06	2.93
422472	R59096	Hs. 279939	mitochondrial carrier homolog 1	9.77E−05	2.89
454136	AA046477	Hs. 62813	insulinoma-associated protein IA-6	4.63E−04	2.89
458818	AI523857	Hs. 232257	ESTs	4.91E−05	2.87
457960	AA771881	Hs. 298149	ESTs	3.65E−03	2.84
446433	AW293404	Hs. 211986	ESTs	1.75E−04	2.73
409212	AI082423	Hs. 141892	ESTs	1.60E−06	2.72
435590	AF216389	Hs. 148932	sema domain, transmembrane domain (TM),	8.04E−05	2.72
402845			ENSP00000246267: KIAA0444 PROTEIN (FRAGME	9.30E−06	2.67
400692			Target Exon	4.42E−10	2.67
411449	AW847318	Hs. 290131	KIAA1819 protein	1.36E−04	2.66
455765	BE082222		gb: QV2-BT0636-070500-196-b08 BT0636 Homo	2.68E−03	2.64
458674	AI304386	Hs. 150836	ESTs	5.42E−07	2.59
455919	BE157345		gb: RC3-HT0371-110300-017-b01 HT0371 Homo	6.41E−04	2.58
412998	BE046254		gb: hn38g09.x2 NC_CGAP_RDF2 Homo sapiens	6.95E−05	2.56
417574	R00348		gb: ye69e06.r1 Soares fetal liver spleen	1.30E−03	2.53
437957	T97069	Hs. 282787	gb: ye50f03.r1 Soares fetal liver spleen	7.21E−08	2.51
452777	AW449161	Hs. 217300	ESTs	2.81E−07	2.50
428547	AF120491	Hs. 184889	potassium voltage-gated channel, Shal-re	3.13E−04	2.49
435715	T78013	Hs. 167279	FYVE-finger-containing Rab5 effector pro	2.14E−04	2.48
456636	AW205448		complement component 3	1.09E−05	2.46
432342	AL036128	Hs. 274404	plasminogen activator, tissue	3.57E−05	2.46
427269	AA400147	Hs. 125234	chromosome 21 open reading frame 54	2.37E−07	2.42
409840	AW502122		gb: UI-HF-BR0p-ajr-c-08-0-UI.r1NIH_MGC_5	2.53E−06	2.42
414562	AW955734	Hs. 112195	ESTs, Weakly similar to 2108402A carniti	1.68E−05	2.41
420796	L34355	Hs. 99931	sarcoglycan, alpha (50 kD dystrophin-asso	3.13E−03	2.38
432745	AI821926		gb: nt78f05.x5 NCI_CGAP_Pr3 Homo sapiens	1.10E−04	2.37
428006	AA418743	Hs. 98306	KIAA1862 protein	8.66E−04	2.35
407563	R06177	Hs. 19613	ESTs	1.89E−08	2.34
400435	AF282973		protocadherin beta 8	1.15E−05	2.32
430878	BE500985	Hs. 248107	EDG-3 (endothelial differentiation, sph	2.20E−05	2.30
413946	BE185066	Hs. 2055	gb: MR1-HT0709-100500-002-c09 HT0709 Homo	1.67E−03	2.30
437015	AI970163	Hs. 237198	ESTs	3.21E−03	2.27
458988	AW410431	Hs. 283670	CGI-119 protein	9.83E−06	2.26
454810	AW832917		gb: QV2-TT0003-161199-013-h06 TT0003 Homo	3.07E−03	2.24
458299	AI024834	Hs. 131729	ESTs	2.45E−06	2.22
438397	AA806478	Hs. 123206	ESTs	1.20E−04	2.22
404224			Target Exon	2.72E−10	2.22
405800			Target Exon	1.33E−06	2.22
411772	BE170301		gb: QV4-HT0536-040500-193-f05 HT0536 Homo	5.16E−04	2.21
401149			Target Exon	9.04E−07	2.20
405334			Target Exon	3.80E−04	2.20
441611	AW590829	Hs. 133463	ESTs	1.73E−08	2.19
407457	AJ242724		gb: Homo sapiens mRNA for partial putativ	4.71E−05	2.18
414024	AA134712	Hs. 22410	gb: zm79g08.r1 Stratagene neuroepithelium	3.72E−07	2.18
450703	AA011202		nuclear factor I/C (CCAAT-binding transc	1.02E−06	2.17
436871	X15667		gb: Human mRNA for glutathione peroxidase	3.18E−07	2.16
417752	C15737	Hs. 269386	ESTs	2.59E−05	2.16
404958			Target Exon	8.05E−05	2.16
459235	BE246010		Homo sapiens mRNA for FLJ00038 protein.	3.75E−05	2.14
416626	H69171	Hs. 205978	ESTs, Moderately similar to ZN91_HUMAN Z	3.33E−03	2.14
419695	N99713	Hs. 109514	ESTs	6.58E−04	2.13
412496	R87592	Hs. 12509	gb: ym91b06.r1 Soares adult brain N2b4HB5	9.12E−05	2.12
426505	BE185582		gb: IL5-HT0731-010500-078-g07 HT0731 Homo	7.94E−04	2.12
453840	AW846927	Hs. 46808	gb: RC3-CT0197-150999-011-A01 CT0197 Homo	1.36E−04	2.12
423053	BE312679		gb: 601148138F1 NIH_MGC_19 Homo sapiens c	1.00E−05	2.12
436690	AA373970	Hs. 183096	ESTs, Highly similar to S15536 homeotic	9.53E−05	2.11
405058			Target Exon	5.01E−07	2.11
426402	BE387327	Hs. 80475	polymerase (RNA) II (DNA directed) polyp	3.46E−06	2.10
449243	AW295031	Hs. 198671	ESTs	1.86E−05	2.10
444163	AI126098		FGENESH predicted RNaseH domain-containi	6.37E−04	2.10
440730	BE561722		gb: 601345466F1 NIH_MGC_8 Homo sapiens cD	5.62E−05	2.09
437161	AA054477	Hs. 25391	ESTs	9.90E−05	2.08
447721	BE619620		lysyl oxidase	1.33E−06	2.08
455973	BE175424		gb: RC4-HT0578-170300-012-d01 HT0578 Homo	1.01E−03	2.06
407598	AW083834	Hs. 246397	ESTs	3.87E−03	2.06
457736	AK000390	Hs. 150549	hypothetical protein FLJ20124	2.25E−03	2.05
433303	AW444881	Hs. 77829	ESTs	1.28E−05	2.04
456040	AW390834	Hs. 75874	pregnancy-associated plasma protein A	2.69E−04	2.04
454707	AW814989		gb: MR1-ST0206-170400-024-g05 ST0206 Homo	2.84E−04	2.04
410739	AL157438	Hs. 324473	Homo sapiens mRNA; cDNA DKFZp434A115 (fr	4.80E−03	2.04
430070	AF197927	Hs. 231967	ALL1 fused gene from 5q31	1.38E−06	2.03
452621	N44030		gb: yy50c11.r1 Soares_multiple_sclerosis—	3.48E−06	2.02
422375	AA768234	Hs. 292430	ESTs	5.15E−04	2.02
419555	AA244416		gb: nc07d11.s1 NCI_CGAP_Pr1 Homo sapiens	1.34E−06	2.01
427840	AI216654	Hs. 98251	ESTs	5.62E−06	2.00
431249	NM_004283	Hs. 8036	RAB3D, member RAS oncogene family	2.90E−03	2.00
438573	AW135084	Hs. 127264	ESTs, Weakly similar to JC5314 CDC28/cdc	1.64E−05	1.98
451402	AI793167		ESTs, Highly similar to AC004836 1 simil	1.74E−04	1.98
447715	AW291714	Hs. 221703	ESTs	1.95E−07	1.98
428744	BE267033	Hs. 192853	ubiquitin-conjugating enzyme E2G 2 (homo	2.70E−04	1.98
414063	H26904	Hs. 75736	apolipoprotein D	1.83E−05	1.98
434646	AF147445		gb: Homo sapiens full length insert cDNA	3.61E−03	1.97
425036	BE467912	Hs. 154294	discs, large (Drosophila) homolog 1	1.65E−03	1.97
452742	AW589945	Hs. 97876	hypothetical protein DKFZp564K0322	1.71E−05	1.96
400663			Target Exon	9.40E−04	1.95
454328	AW372097	Hs. 278429	hepatocellular carcinoma-associated anti	5.19E−03	1.95
403686			C4001366*: gi|9837427|gb|AAG00570.1|AF287	2.69E−04	1.94
402399			C19001025*: gi|11275298|dbj|BAB18302.1|(	5.65E−04	1.94
414584	BE409585	Hs. 117715	hypothetical protein MGC10850	2.52E−05	1.94
409795	AI934808		ESTs, Weakly similar to T46338 hypotheti	6.48E−04	1.93
445123	AI762911	Hs. 145369	ESTs	3.97E−07	1.93
457561	AA331517	Hs. 286055	chimerin (chimaerin) 2	7.32E−04	1.93
421511	AA488940	Hs. 105216	hypothetical protein FLJ11125	4.63E−06	1.93
415167	AA160784	Hs. 26410	ESTs	9.17E−03	1.92
445403	AI222423	Hs. 308322	ESTs	8.85E−04	1.92
442793	AI017798		ESTs, Weakly similar to TI47_HUMAN CARGO	7.50E−08	1.91
401624			Target Exon	6.28E−07	1.91
413537	BE146866		gb: QV4-HT0222-211099-014-f06 HT0222 Homo	2.43E−05	1.90
444832	AI807563	Hs. 148452	ESTs	3.77E−03	1.88
455968	BE168828		gb: QV1-HT0517-020400-145-f04 HT0517 Homo	1.48E−05	1.88
401706			Target Exon	2.57E−04	1.87
416648	R97488		gb: yq53b09.r1 Soares fetal liver spleen	7.47E−05	1.87
458867	AW995393		gb: QV0-BN0042-170300-163-g12 BN0042 Homo	2.20E−07	1.86
405263			ATPase, Na? transporting, alpha 2 () pol	1.42E−04	1.86
457148	AF091035	Hs. 184627	KIAA0118 protein	8.35E−05	1.84
403796			Target Exon	2.31E−03	1.84
450657	AK001579	Hs. 25277	hypothetical protein FLJ21065	3.73E−05	1.84
405639			Target Exon	4.60E−03	1.84
425526	AA359933		gb: EST69040 Fetal lung II Homo sapiens c	1.86E−03	1.84
407290	AA633861	Hs. 12106	ESTs, Weakly similar to ALU7_HUMAN ALU S	5.47E−04	1.83
448647	AI702965	Hs. 45005	hypothetical protein FLJ12960	1.49E−04	1.83
448871	BE616709	Hs. 159265	kruppel-related zinc finger protein hcKr	7.64E−05	1.83
432018	AA524447	Hs. 152377	ESTs	2.23E−04	1.81
433545	AA868510	Hs. 112496	ESTs	5.50E−05	1.81
427789	AA412428	Hs. 48642	hypothetical protein FLJ23093	2.54E−03	1.81
429013	AJ012590	Hs. 194728	hexose-6-phosphate dehydrogenase (glucos	2.54E−05	1.80
446887	AI346656	Hs. 156652	hypothetical protein FLJ22800	7.83E−07	1.79
441718	AW573183	Hs. 127380	ESTs	3.62E−06	1.79
454287	AF075292	Hs. 49585	fibroblast growth factor 18	2.82E−05	1.79
435125	AA381895	Hs. 284204	F-box only protein 29	6.24E−07	1.79
408099	AW151637		ESTs, Moderately similar to Z195_HUMAN Z	1.70E−05	1.78
434884	AF161340		Homo sapiens HSPC077 mRNA, partial cds	3.95E−04	1.77
428303	AW974476	Hs. 183601	regulator of G-protein signalling 16	2.82E−04	1.76
435028	AW193035	Hs. 187370	ESTs	2.89E−03	1.75
421472	NM_003323	Hs. 104636	tubby like protein 2	1.28E−04	1.75
438687	AA814084		ESTs	5.89E−04	1.74
412004	NM_005042	Hs. 73952	praline-rich protein Haelll subfamily 2	6.32E−05	1.74
403794			Target Exon	9.24E−05	1.74
441184	AA922009		ESTs	6.67E−07	1.73
430358	AW604424	Hs. 239891	G protein-coupled receptor 35	1.21E−05	1.73
410312	AW850953		gb: IL3-CT0220-150200-068-A11 CT0220 Homo	4.73E−06	1.73
403772			NM_003061: Homo sapiens slit (Drosophila)	1.08E−04	1.73
405126			Target Exon	2.23E−04	1.72
438338	NM_014861	Hs. 6168	KIAA0703 gene product	4.80E−05	1.72
456782	AK000462	Hs. 132071	ovarian carcinoma immunoreactive antigen	8.79E−05	1.72
422097	X61755	Hs. 111473	homeo box C5	6.28E−03	1.71
415593	F13043	Hs. 6918	ESTs	4.22E−03	1.71
409545	BE296182	Hs. 19002	hypothetical protein MGC4675	8.81E−03	1.71
453855	AA039576	Hs. 37858	ESTs, Weakly similar to ALUB_HUMAN !!!!	5.82E−03	1.71
400729			Target Exon	3.52E−05	1.70
457505	AL044659	Hs. 43791	ESTs	6.22E−04	1.70
420548	AA278246	Hs. 920	ESTs	1.27E−03	1.69
433899	AW628168	Hs. 152684	ESTs	1.22E−03	1.69
423103	AA322029		gb: EST24685 Cerebellum II Homo sapiens c	7.95E−04	1.68
435367	AI917684	Hs. 85524	for muscle specific ring finger 2	2.37E−03	1.68
447135	T58148		gb: yb98g06.s1 Stratagene lung (937210) H	2.13E−06	1.68
429642	X68264	Hs. 211579	melanoma cell adhesion molecule (MCAM) (	1.65E−06	1.68
422189	AF252292	Hs. 112933	Tax interaction protein 40	7.46E−03	1.68
422028	AW090340	Hs. 14337	Homo sapiens cDNA FLJ14407 fis, clone HE	3.17E−03	1.67
441777	AI733440	Hs. 127735	ESTs	8.00E−04	1.67
415897	H08323	Hs. 268712	ESTs	3.51E−04	1.67
403243			Target Exon	3.28E−05	1.66
402690			Target Exon	1.11E−05	1.66
445132	Z44811	Hs. 14928	hypothetical protein FLJ12903	1.10E−05	1.66
405677			Target Exon	9.97E−03	1.66
441477	BE379434	Hs. 192127	Homo sapiens, clone IMAGE: 3609326, mRNA,	1.03E−03	1.66
400522			Target Exon	1.90E−06	1.66
407283	T51008		gb: yb55e08.s1 Stratagene ovary (937217)	7.26E−05	1.65
440509	BE410132	Hs. 134202	ESTs, Weakly similar to T17279 hypotheti	6.14E−06	1.65
453449	W16752	Hs. 32981	sema domain, immunoglobulin domain (Ig),	4.49E−06	1.65
431107	AW451602	Hs. 153590	ESTs	2.58E−06	1.65
410736	AA205850	Hs. 122823	thousand and one amino acid protein kina	2.55E−04	1.65
410255	AA234006	Hs. 321264	LBP protein 32	1.07E−03	1.64
457394	M86528	Hs. 266902	neurotrophin 5 (neurotrophin 4/5)	1.37E−05	1.63
406140			Target Exon	7.83E−06	1.63
408932	AW594172	Hs. 278513	TP53TG3 protein	8.73E−03	1.63
453992	AW014995	Hs. 281080	ESTs	7.00E−06	1.62
418141	AW845738	Hs. 171118	hypothetical protein FLJ00026	1.34E−04	1.62
454430	AI082777	Hs. 61384	sema domain, seven thrombospondin repeat	2.32E−04	1.61
439335	AA742697	Hs. 62492	NM_052863: Homo sapiens secretoglobin, fa	1.22E−05	1.61
433095	AK001092	Hs. 302480	Homo sapiens cDNA FLJ10230 fis, clone HE	4.03E−05	1.61
454527	AW804626	Hs. 151237	hypothetical protein FLJ12526	7.10E−03	1.61
444462	AA127530	Hs. 286035	Homo sapiens mRNA for KIAA1783 protein,	6.17E−04	1.60
435724	N39308	Hs. 117898	ESTs	5.43E−08	1.60
411181	AW820794	Hs. 252406	hypothetical protein FLJ12296 similar to	1.80E−04	1.60
446705	AW206634	Hs. 224879	ESTs	3.59E−06	1.59
416249	R85267	Hs. 107692	ESTs	6.97E−04	1.59
421539	AA292747	Hs. 97296	ESTs	1.44E−04	1.59
423658	AB003062	Hs. 130760	myosin phosphatase, target subunit 2	3.00E−04	1.59
426254	BE018103		PP3111 protein	1.45E−06	1.58
442674	AI124736	Hs. 142921	ESTs	1.19E−03	1.58
407845	AL036518	Hs. 118598	Homo sapiens mRNA for KIAA1878 protein,	2.96E−04	1.58
410626	BE407727	Hs. 199316	gb: 601299771F1 NIH_MGC_21 Homo sapiens c	1.10E−03	1.58
415160	T82802		gb: yd38a04.r1 Soares fetal liver spleen	3.67E−06	1.58
416397	H53035		Homo sapiens AFG3L1 isoform 1 mRNA, part	3.78E−03	1.58
401371			ENSP00000198192*: BA438F9.1 (novel protei	1.37E−04	1.58
457008	AA410446	Hs. 112011	ESTs, Weakly similar to unknown [H.sapie	7.30E−05	1.57
456093	AL135220	Hs. 77579	apoptotic protease activating factor	3.53E−04	1.57
408518	BE162203	Hs. 314758	ESTs	2.86E−03	1.57
406357			Target Exon	1.40E−03	1.56
401554			Target Exon	4.40E−03	1.56
423143	M64676	Hs. 124212	potassium voltage-gated channel, Shaw-re	6.15E−06	1.56
409911	N43177	Hs. 284217	serologically defined colon cancer antig	5.78E−03	1.56
445889	BE465186	Hs. 266958	ESTs	2.38E−05	1.55
405137			Target Exon	1.73E−03	1.55
418525	AW450369	Hs. 86937	ESTs	2.90E−04	1.55
425169	AW292500	Hs. 128514	ESTs	3.54E−03	1.55
404843			C22000088*: gi|6678165|ref|NP_033461.1|s	8.09E−04	1.55
456764	AA325560	Hs. 346401	ESTs	4.17E−04	1.55
412371	AW946621		gb: RC2-ET0021-280400-011-e12 ET0021 Homo	6.83E−03	1.55
458211	AA922156	Hs. 144751	ESTs	1.58E−03	1.55
403613			C3000680*: gi|5852484|gb|AAD54072.1|AF131	2.05E−03	1.54
402534			Target Exon	2.23E−04	1.54
428189	AA424030	Hs. 46627	ESTs	2.07E−06	1.54
401629			ENSP00000251306*: HYPOTHETICAL 42.6 kDa P	1.46E−05	1.54
426449	AL134009	Hs. 169936	Homo sapiens mRNA; cDNA DKFZp586N1918 (f	4.75E−03	1.53
404731			NM_006180*: Homo sapiens neurotrophic tyr	3.51E−03	1.53
422111	W04245	Hs. 107761	ESTs, Weakly similar to unnamed protein	4.17E−04	1.53
451461	AI968438	Hs. 265349	ESTs	4.55E−03	1.53
450235	AA007512	Hs. 17538	ESTs	3.39E−03	1.52
416323	N72630		Homo sapiens genomic DNA, chromosome 21q	1.17E−05	1.52
438808	M73980	Hs. 129053	Homo sapiens NOTCH 1 (N1) mRNA, complete	3.12E−07	1.52
452655	R85491	Hs. 33466	ESTs, Weakly similar to DPOZ_HUMAN DNA P	9.50E−04	1.52
431777	AA570296	Hs. 105470	found in inflammatory zone 1	4.41E−05	1.52
423086	AB028984	Hs. 123420	KIAA1061 protein	2.50E−06	1.51
407173	T64349		gb: yc10d08.s1 Stratagene lung (937210) H	2.11E−04	1.51
449482	AI784266	Hs. 28774	ESTs, Weakly similar to I38022 hypotheti	1.71E−03	1.51
404219			NM_004557*: Homo sapiens Notch (Drosophil	1.02E−05	1.51
441493	AW070446	Hs. 127037	ESTs	6.77E−04	1.51
405913			NM_004349: Homo sapiens core-binding fact	2.61E−03	1.50
458223	AW297673	Hs. 190526	ESTs	6.98E−04	1.50
452854	AA437061	Hs. 14060	prokineticin 1 precursor	1.67E−06	1.50
445735	AW503939	Hs. 107149	novel protein similar to archaeal, yeast	1.23E−03	1.50
446052	AA358760	Hs. 95893	gb: EST67699 Fetal lung II Homo sapiens c	1.00E−06	1.50
407124	R08160		gb: yf18a07.s1 Soares fetal liver spleen	8.86E−03	1.49
458968	AI933128	Hs. 25220	like-glycosyltransferase	1.73E−03	1.49
408937	AA210734	Hs. 291386	ESTs	8.62E−03	1.49
403180			Target Exon	8.69E−05	1.49
432202	BE301302	Hs. 7200	ESTs, Highly similar to AC007055 5 unkno	4.82E−03	1.49
407654	AW064121	Hs. 279175	ESTs	1.06E−03	1.48
437408	AL359598	Hs. 36606	Homo sapiens mRNA; cDNA DKFZp547B086 (fr	7.68E−05	1.48
443495	N95833	Hs. 80395	ESTs	4.96E−05	1.48
436666	AI191588	Hs. 1179	TATA box binding protein (TBP)-associate	6.61E−03	1.48
426330	M77235	Hs. 169331	sodium channel, voltage-gated, type V, a	3.38E−04	1.48
446066	AI343931	Hs. 149383	ESTs	7.17E−05	1.48
422754	AA316476	Hs. 171811	adenylate kinase 2	1.62E−03	1.48
401595			Rag C protein	3.73E−05	1.48
406089			Target Exon	4.83E−03	1.48
401899			Target Exon	8.77E−05	1.47
412433	AA102400		ESTs	7.09E−05	1.47
402137			Target Exon	2.63E−03	1.46
404701			NM_022779: Homo sapiens hypothetical prot	2.50E−03	1.46
455663	BE065679		gb: RC3-BT0316-270400-016-e10 BT0316 Homo	7.55E−04	1.46
407032	U73799		gb: Human dynactin mRNA, partial cds.	1.67E−08	1.46
449904	AW304472	Hs. 200088	ESTs	1.91E−03	1.46
403474			NM_030968: Homo sapiens G protein coupled	2.90E−05	1.45
438991	W78940	Hs. 20526	ESTs	6.38E−03	1.45
443503	AV645438	Hs. 282927	ESTs	7.43E−03	1.45
453224	AI989700	Hs. 232320	ESTs	4.46E−05	1.45
452263	AA025116	Hs. 33333	ESTs	1.96E−05	1.45
405762			CX000374*: gi|11433304|ref|XP_006583.1|h	2.15E−04	1.45
427626	AI364292	Hs. 283696	ESTs, Weakly similar to A43932 mucin 2 p	5.41E−03	1.45
417741	R12418	Hs. 274728	ESTs	1.12E−03	1.45
438526	AI090671	Hs. 134807	hypothetical protein FLJ12057	7.48E−03	1.45
438173	AK001271	Hs. 6092	f-box and leucine-rich repeat protein 2	2.09E−03	1.44
458826	AI918672	Hs. 213783	ESTs	1.92E−05	1.44
415255	R39947	Hs. 7237	ESTs	8.01E−03	1.44
422091	AI906339	Hs. 97927	ESTs	9.01E−03	1.44
433010	AW970018		gb: EST382097 MAGE resequences, MAGK Homo	2.64E−03	1.44
422800	AW953176		Homo sapiens cDNA: FLJ23260 fis, clone C	1.03E−03	1.44
439070	AI733278	Hs. 7621	ESTs	1.64E−03	1.44
405590			CX001497*: qi|4557543|ref|NP_001384.1| ex	1.91E−06	1.43
414648	H54381		gb: yq89a03.s1 Soares fetal liver spleen	1.07E−05	1.43
409319	AW752736	Hs. 33565	ESTs	6.79E−03	1.43
426065	N32049	Hs. 29423	gb: yw96g08.s1 Soares_placenta_8to9weeks—	2.67E−04	1.43
445771	AI804325	Hs. 201060	ESTs	5.21E−04	1.43
418642	AA226049	Hs. 297915	ESTs	2.51E−05	1.42
429521	BE048708	Hs. 50949	ESTs	3.99E−05	1.42
414262	AW975616	Hs. 291469	ESTs	1.22E−04	1.42
437093	AA744334		gb: ny59b06.s1 NCI_CGAP_Pr18 Homo sapiens	1.78E−04	1.42
421093	AA906434	Hs. 3776	zinc finger protein 216	4.09E−05	1.42
404825			C22000161*: gi|2443331|dbj|BAA22375.1|(D	5.52E−03	1.42
408768	AW663111	Hs. 94958	tubulin tyrosine ligase-like 1	8.41E−04	1.41
402638			guanine nucleotide binding protein (G pr	1.03E−03	1.41
406458			C14000133*: gi|1082739|pir|C44324 protea	2.14E−06	1.41
414327	BE408145	Hs. 185254	ESTs, Weakly similar to T24435 hypotheti	2.01E−05	1.41
435026	AA744812	Hs. 177135	ESTs	1.80E−03	1.41
445481	AW661846		ESTs	3.72E−05	1.40
410922	AW810845		gb: MR2-ST0129-221099-013-a03 ST0129 Homo	3.02E−03	1.40
412044	BE086167		gb: PM3-BT0673-260200-001-d01 BT0673 Homo	2.88E−08	1.40
457994	AW136239	Hs. 132922	ESTs, Weakly similar to TI47_HUMAN CARGO	4.12E−07	1.40
448464	AI522053		ESTs	1.16E−03	1.40
442340	AW882532	Hs. 8257	cytokine inducible SH2-containing protei	3.53E−04	1.39
428887	AA437009	Hs. 98984	ESTs	6.17E−09	1.39
436558	AI360238	Hs. 157730	ESTs	3.23E−04	1.39
428406	BE279930	Hs. 98564	hypothetical protein DKFZp434G0920	1.31E−03	1.39
427267	AI201185	Hs. 119164	ESTs	9.05E−04	1.39
436549	AJ297365	Hs. 334478	hypothetical protein MPMGp800M05499Q3	1.76E−04	1.38
404923			NM_020131*: Homo sapiens ataxin-1 ubiquit	3.88E−05	1.38
403209			Target Exon	3.66E−03	1.38
432909	AA570111		ESTs, Weakly similar to ALUE_HUMAN!!!!	8.59E−04	1.38
459304	AW005809	Hs. 158291	ESTs, Weakly similar to CHD4_HUMAN CHROM	5.40E−03	1.38
415597	Z44384		gb: HSC1ZC041 normalized infant brain cDN	5.65E−05	1.38
458544	AI631036	Hs. 196843	ESTs	4.62E−04	1.37
440075	BE268806		gb: 601139917F1 NIH_MGC_8 Homo sapiens cD	2.27E−04	1.37
441194	BE274581		ESTs, Moderately similar to S65657 alpha	6.64E−03	1.37
457451	H06075	Hs. 270232	ESTs	6.68E−06	1.37
400635			C10000818*: gi|7661882|ref|NP_055697.1|K	2.66E−06	1.37
432092	AF135026		kallikrein 9	1.01E−03	1.36
419042	T81429	Hs. 221065	ESTs	1.20E−03	1.36
454537	BE391493		Human DNA sequence from clone RP5-852M4	9.75E−03	1.36
446403	AW452904		gb: UI-H-BI3-aly-h-11-0-UI.s1 NCI_CGAP_Su	8.47E−04	1.36
402349			Target Exon	4.33E−05	1.36
442907	AI023763	Hs. 79707	ESTs	1.21E−03	1.36
436394	AA531187	Hs. 126705	ESTs	5.26E−09	1.36
440745	AW303627	Hs. 143301	ESTs	1.69E−04	1.36
441662	AI807406		ESTs	3.93E−03	1.36
427951	AI826125	Hs. 43546	ESTs	3.49E−03	1.36
458354	AI024181	Hs. 131657	ESTs	3.18E−03	1.36
414871	BE549179	Hs. 29008	gb: 601078714F1 NIH_MGC_12 Homo sapiens c	7.53E−04	1.36
454930	AW845987	Hs. 68864	ESTs, Weakly similar to phosphatidylseri	1.57E−03	1.36
456922	AA477435	Hs. 193669	hypothetical protein DKFZp586J1119	1.19E−03	1.35
453356	BE539237	Hs. 182698	mitochondrial ribosomal protein L20	8.58E−03	1.35
411154	AW819848		gb: QV0-ST0294-070300-151-b04 ST0294 Homo	8.20E−04	1.35
442558	AI000792	Hs. 108209	ESTs	2.62E−04	1.35
459002	AI915933	Hs. 102647	ESTs, Weakly similar to WASP interacting	7.83E−05	1.35
452236	AI130858	Hs. 143218	ESTs	2.66E−03	1.35
456110	AW872878	Hs. 289072	hypothetical protein FLJ22175	9.25E−03	1.35
421324	BE257515	Hs. 103503	deoxyribonuclease I-like 2	9.35E−05	1.34
414614	BE390050	Hs. 48642	hypothetical protein FLJ23093	5.55E−03	1.34
448544	AI535819		gb: jun1.P1.G1 conorm Homo sapiens cDNA 3	9.28E−04	1.34
458575	AW362488	Hs. 12797	DEAD/H (Asp-Glu-Ala-Asp/His) box polypep	9.57E−05	1.34
417597	BE297053	Hs. 347310	hypothetical protein FLJ14627	1.63E−04	1.34
430725	AA485056		ESTs	3.62E−03	1.34
432190	T80206	Hs. 14716	ESTs	6.52E−04	1.34
445690	AW675572	Hs. 193620	ESTs	2.53E−03	1.34
420813	X51501	Hs. 99949	prolactin-induced protein	2.38E−03	1.34
422579	BE407266		gb: 601301004F1 NIH_MGC_21 Homo sapiens c	3.32E−03	1.34
402951			ENSP00000243967*: DJ1100H13.4 (putative R	4.06E−04	1.34
436516	AW134701	Hs. 245358	ESTs	1.00E−03	1.34
424334	AA393460	Hs. 13386	gb: zt71e05.r1 Soares_testis_NHT Homo sap	1.50E−05	1.33
432081	AW972788		gb: EST384883 MAGE resequences, MAGL Homo	9.35E−04	1.33
458306	AF039185	Hs. 41974	Homo sapiens, clone IMAGE: 4100953, mRNA	1.53E−03	1.33
421228	AA811598	Hs. 275809	ESTs	1.31E−04	1.33
402447			C1000201: gi|204416|gb|AAA02627.1|(L0519	6.43E−05	1.33
403545			Target Exon	5.81E−06	1.33
408376	AW971303	Hs. 241869	ESTs	7.57E−03	1.33
420693	NM_001972	Hs. 99863	elastase 2. neutrophil	6.28E−04	1.33
426157	AA370977	Hs. 345728	STAT induced STAT inhibitor 3	1.99E−10	1.33
453196	AW003567		ESTs	1.98E−04	1.32
421798	N74880		N-acylsphingosine amidohydrolase (acid c	4.05E−03	1.32
458077	AA100768	Hs. 48485	ESTs, Weakly similar to I38022 hypotheti	1.60E−03	1.32
400343	AB045830	Hs. 160953	Target	3.15E−04	1.32
402561			Target Exon	2.63E−04	1.32
454803	AW860148		gb: RC0-CT0379-290100-032-b10 CT0379 Homo	4.50E−05	1.32
413619	BE153524		gb: PM0-HT0339-241199-002-C03 HT0339 Homo	2.33E−06	1.31
446749	NM_016069	Hs. 16089	CGI-136 protein	2.11E−05	1.31
447680	AW768676	Hs. 302022	PR domain containing 16	1.19E−03	1.31
425012	T77666	Hs. 92414	Homo sapiens cDNA: FLJ22030 fis, clone H	6.29E−03	1.31
416675	H73802	Hs. 35381	ESTs	1.60E−03	1.31
437568	AI954795	Hs. 156135	ESTs	4.02E−03	1.30
401516			C3001641*: gi|11359861|pir||JC7326 bood P	1.62E−03	1.30
428177	AA423967		ESTs	1.80E−03	1.30
452320	AA042873	Hs. 160412	ESTs	1.14E−03	1.30
442496	R55073	Hs. 76780	ESTs	6.05E−07	1.30
405691			NM_013439*: Homo sapiens paired immunoglo	1.56E−06	1.30
409540	AW409569	Hs. 101550	gb: fh01e09.x1 NIH_MGC_17 Homo sapiens cD	7.89E−05	1.30
411288	AW835511		gb: QV0-LT0015-180200-127-d02 LT0015 Homo	1.34E−03	1.30
418551	T75517		gb: yd63c01.r1 Soares fetal liver spleen	8.37E−03	1.30
415449	H15034		gb: ym20a03.s1 Soares infant brain 1NIB H	1.60E−03	1.29
457677	AA628890		ESTs	1.76E−03	1.29
423310	AA325225	Hs. 124023	Homo sapiens cDNA FLJ14218 fis, clone NT	1.17E−03	1.29
420800	AI041991	Hs. 132227	Homo sapiens, clone MGC: 13138, mRNA, com	2.29E−03	1.29
438292	AI139006	Hs. 122352	ESTs	1.97E−03	1.29
412429	AV650262	Hs. 75765	GRO2 oncogene	5.81E−08	1.29
446528	AU076640	Hs. 15243	nucleolar protein 1 (120 kD)	1.99E−04	1.28
454908	AW840458		gb: CM3-LT0079-180200-096<01 LT0079 Homo	1.91E−03	1.28
423505	AF064090	Hs. 129708	tumor necrosis factor (ligand) superfami	9.02E−04	1.28
404126			ENSP00000211797*: Helicase SKI2W (Helicas	2.12E−03	1.28
432749	NM_014438	Hs. 278909	interleukin 1, eta	1.09E−03	1.28
450675	AA010662	Hs. 188639	ESTs	4.57E−04	1.28
404046			NM_019120*: Homo sapiens protocadherin be	9.68E−05	1.28
402991			Target Exon	3.40E−04	1.28
452165	R17489	Hs. 28264	Homo sapiens mRNA; cDNA DKFZp564L0822 (f	2.07E−04	1.28
445268	AI218358	Hs. 175048	ESTs	4.78E−03	1.28
433664	AW292176	Hs. 245834	ESTs	8.30E−03	1.27
416348	H65887	Hs. 272163	ESTs	1.09E−03	1.27
442705	AI264634	Hs. 131127	ESTs	5.94E−04	1.27
440625	BE539853	Hs. 22452	Homo sapiens mRNA for KIAA1737 protein,	3.66E−04	1.27
420459	AF016045	Hs. 97905	ovo (Drosophila) homolog-like 1	6.83E−03	1.27
413737	BE160704		gb: PM1-HT0422-170100-005-b07 HT0422 Homo	5.31E−06	1.27
408183	AW968065	Hs. 44143	polybromo 1	1.93E−03	1.27
420380	AA640891	Hs. 102406	ESTs	4.61E−05	1.27
454186	BE141030		gb: MR0-HT0067-201099-002-h11 HT0067 Homo	2.63E−03	1.27
438692	AB007950	Hs. 6360	KIAA0481 gene product	5.51E−04	1.27
402320			f-box and leucine-rich repeat protein 7	6.75E−06	1.27
414189	BE378841	Hs. 73452	hypothetical protein MGC10791	3.64E−05	1.26
413961	BE207098		gb: ba10e09.y1 NIH_MGC_7 Homo sapiens cDN	5.19E−03	1.26
454598	AW809716		gb: MR4-ST0124-241199-026-h09 ST0124 Homo	1.50E−04	1.26
408935	BE539706	Hs. 285363	ESTs	7.92E−04	1.26
450653	AI191771	Hs. 29764	wingless-type MMTV integration site fami	4.58E−03	1.26
403227			Target Exon	1.60E−03	1.26
439471	W69839	Hs. 58033	ESTs	3.83E−03	1.26
433782	AF090945	Hs. 306564	Homo sapiens clone HQ0670	8.19E−05	1.26
425446	U34802	Hs. 157433	gap junction protein, alpha 8,50 kD (con	6.39E−07	1.26
417313	AA195602		gb: zr32f09.r1 Soares_NhHMPu_S1 Homo sapi	3.92E−05	1.26
437180	BE180234	Hs. 281462	Homo sapiens cDNA FLJ14793 fis, clone NT	7.39E−04	1.25
436419	AI948626	Hs. 171356	ESTs	1.91E−03	1.25
424713	AI660243	Hs. 318545	transmembrane protease, serine 2	7.11E−03	1.25
401265			C18000090*: gi|6678656|ref|NP_032506.1|1	3.20E−03	1.25
426212	S71824	Hs. 167988	neural cell adhesion molecule 1	5.71E−05	1.25
410285	AA083609		gb: zm63d05.r1 Stratagene fibroblast (937	7.72E−04	1.25
408432	AW195262		gb: xn67b05.x1 NCI_CGAP_CML1 Homo sapiens	6.30E−04	1.25
449405	AA001350		gb: zh83h05.r1 Soares_fetal_liver_spleen—	6.58E−03	1.25
431357	T81154		gb: yd24f01.r1 Soares fetal liver spleen	4.61E−03	1.24
459012	AA047221	Hs. 59752	ESTs	7.13E−03	1.24
408725	AA131539	Hs. 15669	ESTs	4.13E−04	1.24
428568	AC004755		Homo sapiens chromosome 19, fosmid 37502	2.08E−04	1.24
453492	AA235214	Hs. 184793	DKFZP434F195 protein	2.09E−03	1.24
404247			NM_000500*: Homo sapiens cytochrome P450,	3.47E−03	1.24
427595	NM_016153	Hs. 179756	LW-1	2.01E−03	1.24
408038	AW138673	Hs. 252928	ESTs	1.35E−05	1.24
440353	AI366674	Hs. 286194	hypothetical protein FLJ22233	8.84E−03	1.24
438649	AA813136	Hs. 143014	ESTs	1.75E−03	1.24
406370			interleukin 11	1.24E−04	1.24
415037	AA159478		ESTs	2.21E−04	1.24
451005	AI751946	Hs. 20017	chromosome 22 open reading frame 4	3.85E−03	1.24
404075			Target Exon	3.41E−03	1.24
401703			NM_001053: Homo sapiens somatostatin rece	1.24E−04	1.23
402252			Target Exon	4.93E−06	1.23
412538	T31119	Hs. 7177	ESTs	7.66E−04	1.23
440190	AW752597		gb: IL3-CT0214-161299-045-B06 CT0214 Homo	3.52E−03	1.23
402316			NM_013447: Homo sapiens egf-like module c	3.46E−03	1.23
437913	AI140825	Hs. 121623	ESTs	9.11E−04	1.23
458146	AI286094		ESTs	9.62E−05	1.23
452218	AI936010	Hs. 17649	ESTs	3.58E−04	1.23
437057	BE548498	Hs. 84529	ESTs, Weakly similar to Z202_HUMAN ZINC	3.02E−03	1.22
400818			Target Exon	1.76E−05	1.22
409749	AW977045	Hs. 185981	ESTs, Weakly similar to gag [H. sapiens]	1.55E−05	1.22
422626	AA344932	Hs. 118786	metallothionein 2A	4.89E−04	1.22
416666	H73028	Hs. 268992	ESTs	1.34E−05	1.21
409975	AW839324		gb: CM0-LT0069-210100-157-h04 LT0069 Homo	1.78E−03	1.21
404900			NM_025213: Homo sapiens spectrin, beta, n	8.14E−03	1.21
416369	AW160617	Hs. 24884	hypothetical protein FLJ13390 similar to	1.83E−04	1.21
417761	R13727	Hs. 21435	ESTs	2.43E−04	1.21
419299	AI311085		hypothetical protein FLJ22573	2.01E−04	1.21
400877			cofilin 1 (non-muscle)	8.03E−03	1.21
437032	AW867372	Hs. 153261	immunoglobulin heavy constant mu	1.61E−03	1.21
423358	AI815474	Hs. 343866	gb: au47f10.y1 Schneider fetal brain 0000	1.38E−04	1.21
400111			Eos Control	3.47E−03	1.21
402610			Target Exon	4.97E−04	1.21
404769			NM_007037*: Homo sapiens a disintegrin-li	8.45E−05	1.20
416694	AW161284	Hs. 79564	neuronal PAS domain protein 1	4.72E−03	1.20
433182	AB039920	Hs. 127821	BWRT protein	5.55E−07	1.20
453899	AW134536	Hs. 243994	ESTs	2.91E−03	1.20
447563	BE536115	Hs. 160983	EST	1.53E−04	1.20
423966	AF233523	Hs. 136506	spectrin, beta, non-erythrocytic 5	2.87E−05	1.20
447224	BE617125	Hs. 142076	gb: 601441664F1 NIH_MGC_65 Homo sapiens c	4.73E−05	1.20
456618	BE245649	Hs. 345728	STAT induced STAT inhibitor 3	3.29E−05	1.20
432345	AW780191	Hs. 6523	chromosome 1 open reading frame 12	6.34E−03	1.20
458281	AW661820	Hs. 44131	ESTs	1.36E−06	1.19
409280	AW372614	Hs. 82962	rTS beta protein	1.51E−04	1.19
436375	AJ227870		gb: Homo sapiens partial mRNA; ID YG81-1	6.60E−03	1.19
423308	AI365680	Hs. 114085	Homo sapiens mRNA for KIAA1755 protein.	6.34E−05	1.19
417213	BE257508	Hs. 24719	modulator of apoptosis 1	7.70E−05	1.19
427983	M17706	Hs. 2233	colony stimulating factor 3 (granulocyte	5.82E−06	1.18
409818	AW500969		gb: UI-HF-BP0p-aiy-c-07-0-Ul.r1 NIH_MGC_5	7.58E−03	1.18
453741	AW855522		gb: CM4-CT0275-040500-521-c06 CT0275 Homo	1.98E−04	1.18
447455	H38335	Hs. 6750	Homo sapiens mRNA for FLJ00058 protein,	1.35E−03	1.18
402863			C1000493*: gi|9506977|ref|NP_062075.1| ph	3.85E−03	1.18
439665	W93979		gb: zd97h10.r1 Soares_fetal_heart_NbHH19W	2.71E−03	1.18
453198	AI470361	Hs. 61684	ESTs, Weakly similar to T17307 hypotheti	4.42E−06	1.18
458025	AI275406	Hs. 32450	gb: ql63c10.x1 Soares_NhHMPu_S1 Homo sapi	1.60E−05	1.18
439547	BE000242	Hs. 192068	ESTs	5.54E−03	1.17
429947	AA461163	Hs. 270391	ESTs, Moderately similar to ALU1_HUMAN A	3.37E−03	1.17
455977	BE176477		gb: RC3-HT0585-160300-022-b01 HT0585 Homo	2.00E−04	1.17
457424	AW876082		gb: CM4-PT0015-071299-057-e05 PT0015 Homo	8.04E−04	1.17
430204	AA618335		ESTs, Weakly similar to YKQ3_CAEEL HYPOT	2.57E−03	1.17
450335	BE218355	Hs. 201781	ESTs, Weakly similar to B34087 hypotheti	1.65E−04	1.17
458237	AI741225	Hs. 20924	ESTs, Weakly similar to neogenin [H.sapi	5.20E−08	1.17
444295	AI201301	Hs. 143837	ESTs	5.95E−03	1.17
441860	AW451330	Hs. 348198	hypothetical protein FLJ20262	6.20E−07	1.17
435218	T84045	Hs. 119321	ESTs	2.19E−03	1.17
430885	U60181	Hs. 248115	growth hormone secretagogue receptor	6.04E−07	1.17
402012			ubiquitin specific protease 15	2.10E−04	1.17
457204	BE264152	Hs. 221994	ESTs	4.15E−04	1.17
458095	AI375740	Hs. 54580	ring finger protein 27	5.49E−03	1.17
455638	BE063665		gb: RC0-BT0291-031199-031-d08 BT0291 Homo	9.13E−05	1.16
450799	AW407504		gb: UI-HF-BM0-adk-g-12-0-Ul.r1 NIH_MGC_38	2.38E−04	1.16
430326	BE251590	Hs. 239370	DKFZP727I051 protein	2.52E−03	1.16
431256	NM_006093	Hs. 251386	proteoglycan 3	2.66E−05	1.16
458857	AI627342	Hs. 224601	ESTs	3.20E−03	1.16
412944	AA384110	Hs. 197143	ESTs	4.33E−03	1.16
449721	AW073727	Hs. 210265	ESTs	1.02E−04	1.16
452773	AW138920	Hs. 342009	ESTs	8.96E−03	1.16
431972	AI805145	Hs. 191711	ESTs, Weakly similar to T2D3_HUMAN TRANS	1.12E−04	1.16
402411			C1002484*: gi|12052832|emb|CAB66589.1| (A	2.35E−03	1.16
421432	AL049553	Hs. 104311	novel protein with MAM domain	1.40E−03	1.15
444207	AI565004		cathepsin D (lysosomal aspartyl protease	2.97E−07	1.15
423266	AA323875	Hs. 193574	ESTs	5.04E−03	1.15
455194	AW947513		gb: RC0-MT0002-140300-011-e04 MT0002 Homo	3.49E−05	1.15
440054	AW661947	Hs. 6891	splicing factor, arginine/serine-rich 6	4.89E−05	1.15
403567			Target Exon	7.42E−03	1.15
413309	BE312608		gb: 601151425F1 NIH_MGC_19 Homo sapiens c	1.75E−06	1.15
457140	AI279960	Hs. 178140	ESTs	7.01E−04	1.15
458526	AI202885	Hs. 148611	ESTs	1.35E−03	1.15
430991	AW968826	Hs. 106432	Homo sapiens cDNA FLJ13410 fis, clone PL	3.98E−06	1.15
401831			C17000644*: gi|631600|pir||S47094 hypothe	5.23E−03	1.15
403248			ESTs, Weakly similar to I78885 serine/th	5.87E−04	1.15
419909	AL136653	Hs. 93675	decidual protein induced by progesterone	8.17E−05	1.14
444552	AW295211	Hs. 230777	ESTs	2.00E−03	1.14
441580	AA938999	Hs. 271414	ESTs, Moderately similar to ALU7_HUMAN A	2.38E−05	1.14
402190			C19000835*: gi|10946730|ref|NP_067362.1|	6.88E−06	1.14
414156	BE392588	Hs. 75777	transgelin	5.43E−03	1.14
416007	N68218	Hs. 105998	ESTs	1.13E−03	1.14
455291	S72043	Hs. 73133	metallothionein 3 (growth inhibitory fac	5.19E−05	1.14
456523	AI083668	Hs. 50601	hypothetical protein MGC10986	4.77E−04	1.14
414314	BE312991	Hs. 50535	gb: 601150275F1 NIH_MGC_19 Homo sapiens c	4.85E−03	1.14
433091	Y12642	Hs. 3185	lymphocyte antigen 6 complex, locus D	3.42E−03	1.14
402878			ENSP00000217420*: BA122O1.1 (A novel prot	2.18E−05	1.14
417721	R11266	Hs. 20755	ESTs	1.24E−03	1.14
416115	BE147652		gb: RC1-HT0229-030500-111-a05 HT0229 Homo	2.60E−05	1.14
401008			Target Exon	4.08E−04	1.14
442040	AW294162	Hs. 301062	UDP-N-acetyl-alpha-D-galactosamine: polyp	3.70E−03	1.14
437216	H13364		gb: yl71b11.r1 Soares infant brain 1NIB H	1.48E−03	1.14
401037			C11000425: gi|4507721|ref|NP_003310.1| ti	2.01E−10	1.14
441813	BE564575	Hs. 151093	hypothetical protein DKFZp434G1415	5.42E−04	1.14
404187			NM_019602: Homo sapiens butyrophilin-like	1.28E−03	1.14
445071	AI280246	Hs. 149504	ESTs	2.53E−03	1.14
444903	AW103062	Hs. 160391	ESTs	6.10E−03	1.13
458863	BE281219	Hs. 179260	chromosome 14 open reading frame 4	3.83E−03	1.13
438327	H87407		chorionic gonadotropin, beta polypeptide	2.14E−05	1.13
407404	AF040257		gb: Homo sapiens TNF receptor homolog mRN	5.77E−03	1.13
459014	AW292935	Hs. 100057	Human DNA sequence from clone RP11-550O8	7.10E−03	1.13
414182	AA136301		KIAA1105 protein	7.83E−04	1.13
402869			Target Exon	6.45E−05	1.13
420772	AW752656	Hs. 222707	KIAA1718 protein	4.72E−04	1.13
404504			Target Exon	1.50E−03	1.13
456825	H67220	Hs. 169681	death effector domain-containing	4.95E−03	1.13
405593			Target Exon	4.73E−04	1.13
420167	AA256113	Hs. 60659	ESTs, Weakly similar to T46471 hypotheti	8.70E−04	1.13
454077	AC005952	Hs. 37062	insulin-like 3 (Leydig cell)	2.15E−03	1.13
412755	BE144306	Hs. 179891	ESTs, Weakly similar to P4HA_HUMAN PROLY	1.78E−03	1.13
417639	R10467	Hs. 339793	ESTs, Weakly similar to ALU1_HUMAN ALU S	6.58E−03	1.13
449684	AI659166	Hs. 207144	ESTs	8.20E−03	1.12
442770	AI017267	Hs. 203763	ESTs	6.56E−03	1.12
402255			NM_031417*: Homo sapiens MAP/microtubule	4.32E−04	1.12
448943	AI608810	Hs. 193288	ESTs	1.93E−04	1.12
438254	AW269804	Hs. 153019	ESTs	8.64E−03	1.12
428653	AA135370	Hs. 188536	Homo sapiens cDNA: FLJ21635 fis, clone C	1.94E−03	1.12
406146			NM_003319*: Homo sapiens titin (TTN), mRN	8.57E−03	1.12
446947	AF146747	Hs. 232165	polycythemia rubra vera 1; cell surface	5.74E−04	1.12
435264	AI247780	Hs. 117036	ESTs	2.54E−03	1.12
444459	AI680624	Hs. 148676	ESTs	8.40E−04	1.12
444279	U62432	Hs. 89605	cholinergic receptor, nicotinic, alpha p	4.90E−05	1.12
403722			C4001282: gi|7662006|ref|NP_055550.1| KIA	3.96E−03	1.12
452316	AA298484	Hs. 61265	ESTs, Moderately similar to G786_HUMAN P	2.13E−04	1.12
409382	AA071244		gb: zm73g03.r1 Stratagene neuroepithelium	4.57E−03	1.12
452947	AW130413		gb: xf50f04.x1 NCI_CGAP_Gas4 Homo sapiens	1.01E−04	1.12
446900	AV660909	Hs. 282705	ESTs	3.36E−03	1.12
447955	BE544271	Hs. 288390	hypothetical protein FLJ22795	2.44E−07	1.12
451383	AW239364	Hs. 20242	hypothetical protein FLJ12788	6.26E−03	1.12
408112	AW451982	Hs. 248613	ESTs	1.07E−03	1.12
404805			ENSP00000252109*: KIAA1043 PROTEIN (FRAGM	2.50E−04	1.12
403830			NM_001328*: Homo sapiens C-terminal bindi	1.78E−03	1.11
411507	AW850140		gb: IL3-CT0219-261099-023-D11 CT0219 Homo	6.34E−03	1.11
448169	BE252749	Hs. 20558	hypothetical protein FLJ20345	4.28E−03	1.11
414125	BE253197	Hs. 334520	hypothetical protein MGC15613	1.73E−03	1.11
442522	AI087038	Hs. 146592	ESTs, Weakly similar to ALU7_HUMAN ALU S	6.74E−04	1.11
447468	AL109959	Hs. 18632	Homo sapiens mRNA full length insert cDN	5.61E−05	1.11
418028	R36212	Hs. 235534	ESTs, Weakly similar to ALU5_HUMAN ALU S	8.67E−03	1.11
419274	U09877	Hs. 89864	superkiller viralicidic activity 2 (S. c	1.52E−03	1.11
450545	AW135582	Hs. 201767	ESTs	2.51E−06	1.11
457840	AJ245874	Hs. 4245	chromosome 11 hypothetical protein ORF3	2.53E−03	1.11
404909			NM_025213: Homo sapiens spectrin, beta, n	5.66E−04	1.11
412419	AW948630		gb: QV0-FT0001-050500-226-g05 FT0001 Homo	4.87E−03	1.11
456126	AA164743	Hs. 187617	hypothetical protein FLJ13941	6.48E−04	1.10
401450			NM_031464*: Homo sapiens hypothetical pro	5.69E−03	1.10
428680	U69199		ESTs, Weakly similar to CGHU1S collagen	7.32E−04	1.10
423499	AW608884	Hs. 28068	ESTs	5.44E−05	1.10
447755	AI802667	Hs. 161348	ESTs	6.52E−04	1.10
426070	AF111170	Hs. 306165	Homo sapiens 14q32 Jagged2 gene, complet	7.77E−05	1.10
407631	AW574891	Hs. 55067	hypothetical protein MGC15437	2.49E−03	1.10
441548	AW394255	Hs. 127143	ESTs	2.03E−04	1.10
430820	AF194815		immunoglobulin lambda variable 4-3	2.28E−03	1.10
456469	NM_005109	Hs. 95220	oxidative-stress responsive 1	4.60E−05	1.10
420239	NM_005544	Hs. 96063	insulin receptor substrate 1	8.63E−03	1.10
446541	N73773	Hs. 282950	ESTs	2.36E−03	1.10
417469	AW189533	Hs. 252748	Homo sapiens cDNA FLJ20394 fis, clone KA	8.97E−04	1.10
458126	AW979136	Hs. 124629	ESTs	1.82E−04	1.10
442364	AA993149	Hs. 129895	ESTs, Moderately similar to TBX3_HUMAN T	2.74E−04	1.10
420958	AA309431	Hs. 66	interleukin 1 receptor-like 1	1.93E−04	1.10
431111	AB033072	Hs. 250015	KIAA1246 protein	3.00E−05	1.09
435773	AW022047	Hs. 41119	otoraplin	2.74E−04	1.09
431365	AA504080	Hs. 191958	immunoglobulin superfamily receptor tran	1.23E−03	1.09
415016	N62934		ESTs	2.17E−04	1.09
459233	AI939966		gb: MR0-CT0015-160799-002-b06 CT0015 Homo	9.36E−03	1.09
454063	AF171928	Hs. 37055	fibroblast growth factor 5	5.43E−03	1.09
412518	BE047637	Hs. 334859	hypothetical protein FLJ10297	3.60E−06	1.09
424324	AA346316		gb: EST52440 Greater omentum tumor Homo s	1.61E−03	1.09
412202	AW900890	Hs. 21782	ESTs, Weakly similar to ALU7_HUMAN ALU S	1.69E−03	1.09
453573	AL042961	Hs. 95111	Homo sapiens cDNA: FLJ23080 fis, clone L	2.27E−04	1.09
420599	AW294971	Hs. 172084	Homo sapiens, clone IMAGE: 3627860, mRNA,	4.38E−04	1.09
416416	H73127	Hs. 141269	ESTs, Moderately similar to ZN91_HUMAN Z	7.56E−03	1.09
405316			C7002129*: gi|3638957|gb|AAC36301.1|(AC0	3.56E−05	1.09
404364			Target Exon	4.89E−03	1.09
445097	W26975	Hs. 46736	hypothetical protein FLJ23476	3.64E−04	1.09
431807	AW970894	Hs. 324430	ESTs, Moderately similar to 1207289A rev	1.66E−04	1.09
439760	AL355741	Hs. 21641	Homo sapiens mRNA full length insert cDN	1.36E−04	1.09
425952	BE336863	Hs. 184456	hypothetical protein	6.92E−05	1.08
406138			NM_000179*: Homo sapiens mutS (E. coli) h	5.55E−03	1.08
452155	AA812225	Hs. 45719	KIAA0823 protein	4.47E−04	1.08
422388	AA310006		gb: EST181073 Jurkat T-cells V Homo sapie	6.14E−03	1.08
459285	BE407166	Hs. 334812	hypothetical protein DKFZp586K0717	4.84E−04	1.08
424397	AI950320		gb: wp08d10.x1 NCI_CGAP_Kid12 Homo sapien	7.44E−03	1.08
451285	AW137912	Hs. 227583	Homo sapiens chromosome X map Xp11.23 L-	8.92E−05	1.08
441395	AI681412	Hs. 176655	ESTs	3.36E−04	1.08
452703	AW299887	Hs. 213402	ESTs	2.32E−03	1.08
402338			Target Exon	4.16E−05	1.08
420988	AW006352	Hs. 159643	ESTs, Weakly similar to T32554 hypotheti	3.36E−03	1.08
409510	AW877400	Hs. 191782	ESTs, Weakly similar to ALU1_HUMAN ALU S	6.11E−04	1.08
449236	AJ403126	Hs. 26373	Homo sapiens cDNA: FLJ23449 fis. clone H	2.62E−03	1.08
420243	AA256874	Hs. 187631	ESTs, Weakly similar to Y076_HUMAN HYPOT	6.50E−03	1.08
404244			Target Exon	3.53E−03	1.08
423546	AW341131	Hs. 146345	ESTs	1.20E−04	1.08
417967	BE244373	Hs. 1119	nuclear receptor subfamily 4, group A, m	9.37E−05	1.07
418784	T41418		gb: ph1h3_19/1TV Outward Alu-primed hncDN	1.50E−03	1.07
412682	AW983772		gb: RC3-HN0002-060400-012-h09 HN0002 Homo	2.24E−03	1.07
417408	F17211	Hs. 86092	Homo sapiens skeletal myosin light chain	2.00E−04	1.07
452104	NM_000197	Hs. 477	hydroxysteroid (17-beta) dehydrogenase 3	9.02E−04	1.07
408710	Y10256	Hs. 47007	mitogen-activated protein kinase kinase	3.05E−05	1.07
402124			NM_031891: Homo sapiens cadherin 20, type	3.36E−03	1.07
400470			Target Exon	5.96E−03	1.07
420357	U94333	Hs. 97199	complement component C1q receptor	3.40E−03	1.07
424173	AW138201	Hs. 101064	Homo sapiens cDNA FLJ12777 fis. clone NT	1.18E−03	1.07
440517	AW139632	Hs. 132246	ESTs	1.93E−04	1.07
438357	AI042101	Hs. 294107	ESTs	8.89E−03	1.07
428813	AA436063	Hs. 25734	ESTs	5.80E−03	1.07
406279			C18000033*: gi|5901944|ref|NP_008977.1|e	9.43E−03	1.07
402635			KIAA0408 gene product	9.81E−04	1.06
417329	AI190413	Hs. 8373	ESTs	9.11E−10	1.06
456059	BE543127	Hs. 336948	Homo sapiens, clone IMAGE: 3530891, mRNA,	1.83E−04	1.06
401532			C15001264*: gi|12737280|ref|XP_006682.2|	5.46E−04	1.06
403358			NM_006898*: Homo sapiens homeo box D3 (HO	1.30E−04	1.06
441250	AA926736	Hs. 131338	ESTs	6.75E−03	1.06
413772	BE163499		gb: QV3-HT0460-160200-092-d02 HT0460 Homo	1.16E−03	1.06
458522	AW452054	Hs. 161139	ESTs	2.12E−04	1.06
406755	N80129	Hs. 199263	metallothionein 1L	2.56E−06	1.06
438540	AA810021	Hs. 136906	ESTs	8.27E−05	1.06
402517			Target Exon	8.49E−05	1.06
422867	L32137	Hs. 1584	cartilage oligomeric matrix protein (pse	8.26E−03	1.06
433299	AA582324		ESTs	1.19E−04	1.06
457165	AL353972	Hs. 202613	ESTs	5.47E−04	1.06
440371	BE268550	Hs. 80449	Homo sapiens, clone IMAGE: 3535294, mRNA,	4.10E−03	1.06
414205	BE382438		Homo sapiens, clone IMAGE: 3690478, mRNA,	1.89E−03	1.06
421453	AA234652	Hs. 104555	neuropeptide FF-amide peptide precursor	3.52E−04	1.06
415515	F11327	Hs. 167406	gb: HSC2VD101 normalized infant brain cDN	1.44E−07	1.06
441638	AW293202	Hs. 133451	ESTs	6.88E−03	1.06
400576			Target Exon	1.45E−04	1.06
422221	AA306649	Hs. 169370	FYN oncogene related to SRC, FGR, YES	8.73E−03	1.05
440187	AI814224	Hs. 148565	ESTs	8.70E−03	1.05
410137	AI244459	Hs. 110826	trinucleotide repeat containing 9	5.49E−03	1.05
436537	AI201305	Hs. 335027	ESTs	5.64E−03	1.05
454397	AW974648		gb: EST386752 MAGE resequences, MAGM Homo	3.26E−03	1.05
432767	NM_014114	Hs. 278928	PRO0097 protein	7.72E−03	1.05
456013	T92048	Hs. 324531	gb: yd54g12.s1 Soares fetal liver spleen	1.08E−04	1.05
438233	W52448	Hs. 56147	ESTs	9.94E−03	1.05
442400	AW381148	Hs. 169407	2,3-bisphosphoglycerate mutase	6.12E−03	1.05
424648	AA344576	Hs. 17253	gb: EST50478 Gall bladder I Homo sapiens	2.96E−03	1.05
404907			NM_025213: Homo sapiens spectrin, beta, n	9.51E−06	1.05
409487	H19886		gb: yn57a05.r1 Soares adult brain N2b5HB5	1.22E−04	1.05
422311	AF073515	Hs. 114948	cytokine receptor-like factor 1	4.30E−04	1.05
431151	BE207083		gb: ba10d10.y1 NIH_MGC_7 Homo sapiens cDN	4.15E−03	1.05
458891	AI659166	Hs. 207144	ESTs	1.35E−05	1.05
452972	M31732	Hs. 31210	B-cell CLL/lymphoma 3	5.22E−05	1.05
456767	AI086412	Hs. 129064	Homo sapiens chromosome 19, cosmid F2216	1.04E−04	1.05
419017	T83961		gb: yd76c08.s1 Soares fetal liver spleen	4.83E−05	1.05
426738	AA421097	Hs. 291902	ESTs	7.01E−06	1.04
414386	X00442	Hs. 75990	haptoglobin	1.19E−06	1.04
436234	AI809027		ESTs	1.15E−04	1.04
437343	AI521190	Hs. 165983	hypothetical C2H2 zinc finger protein FL	1.58E−03	1.04
413042	BE061618		gb: RC6-BT0252-151099-011-c05 BT0252 Homo	4.40E−03	1.04
400765			Target Exon	2.94E−05	1.04
453989	M63962	Hs. 36992	ATPase, H? exchanging, alpha polypeptide	1.57E−03	1.04
422743	BE304678	Hs. 119598	ribosomal protein L3	5.39E−04	1.04
454065	BE394588		gb: 601311808F1 NIH_MGC_44 Homo sapiens c	5.26E−05	1.04
405201			Target Exon	6.03E−03	1.04
436221	AK001781	Hs. 296543	Homo sapiens cDNA FLJ10919 fis, clone OV	4.68E−03	1.04
414376	BE393856	Hs. 66915	ESTs, Weakly similar to 16.7 Kd protein [	1.13E−03	1.04
428633	AW450428	Hs. 112050	ESTs	1.15E−05	1.04
433821	AW182416		ESTs	1.96E−04	1.04
448401	AI498509		ESTs	3.15E−03	1.04
408278	AW876813		phosphoglycerate dehydrogenase	4.02E−05	1.04
405282			Target Exon	2.01E−03	1.04
439548	AA086045	Hs. 137313	ESTs	6.15E−04	1.03
444788	AI871122	Hs. 202821	ESTs	3.94E−04	1.03
430842	AC002511	Hs. 272485	G protein-coupled receptor 41	8.52E−03	1.03
434179	AI743448	Hs. 116177	ESTs	3.72E−03	1.03
427827	AA416577	Hs. 189105	ESTs, Weakly similar to NBR13 [H. sapiens	8.89E−03	1.03
412139	BE044976		gb: hn25b10.x1 NCI_CGAP_Thy7 Homo sapiens	5.90E−03	1.03
445500	AW451938	Hs. 257512	ESTs	4.34E−03	1.03
452151	AI190405	Hs. 143127	ESTs	8.32E−03	1.03
412474	AI791451		gb: ni50c09.y5 NCI_CGAP_Ov2 Homo sapiens	1.42E−03	1.03
407382	AA503620		gb: ne49b08.s1 NCI_CGAP_Co3 Homo sapiens	5.88E−06	1.03
413805	AW945740	Hs. 289293	ESTs	1.11E−03	1.03
448020	H06022	Hs. 334916	Homo sapiens, clone MGC: 17331, mRNA, com	9.93E−03	1.03
407586	Z37544	Hs. 37121	phospholipase C, beta 3 (phosphatidylino	1.14E−04	1.03
438998	AF075064		gb: Homo sapiens full length insert cDNA	2.30E−03	1.03
402022			Target Exon	8.26E−04	1.03
442321	AF207664	Hs. 8230	a disintegrin-like and metalloprotease (	1.86E−06	1.03
459375	BE251770		gb: 601112470F1 NIH_MGC_16 Homo sapiens c	3.01E−04	1.03
418003	AA976107	Hs. 128691	Homo sapiens mRNA for KIAA1762 protein,	1.54E−03	1.03
439694	AA843915	Hs. 54707	ESTs	3.55E−04	1.02
458318	BE177830		gb: RC1-HT0598-120400-022-b08 HT0598 Homo	7.76E−04	1.02
435680	H50946	Hs. 284183	Homo sapiens galectin-related inhibitor	1.38E−05	1.02
445179	AI949743	Hs. 224768	ESTs	4.44E−03	1.02
455932	BE158451		gb: CM1-HT0390-301199-052-b01 HT0390 Homo	2.79E−04	1.02
420429	AW293291	Hs. 182382	ESTs	7.07E−03	1.02
446185	AI279191	Hs. 149454	ESTs, Weakly similar to DSR6_HUMAN DOWN	3.70E−03	1.02
410628	AI131408	Hs. 68756	ESTs, Moderately similar to similar to s	1.52E−05	1.02
428739	AA700158	Hs. 301755	Homo sapiens cDNA FLJ11465 fis, clone HE	9.54E−03	1.02
409651	H96643	Hs. 283565	FOS-like antigen-1	4.45E−09	1.02
445311	AW027556	Hs. 345522	ESTs	9.11E−03	1.02
403579			Target Exon	4.78E−04	1.02
403957			Target Exon	1.30E−04	1.02
415471	F09747	Hs. 268707	ESTs	6.85E−04	1.02
440763	AB028988	Hs. 7407	KIAA1065 protein	8.27E−04	1.01
445474	AI240014	Hs. 259558	ESTs	5.32E−04	1.01
408690	AW864542		gb: PM4-SN0016-120500-003-h02 SN0016 Homo	1.89E−03	1.01
442574	AI932361	Hs. 238039	hypothetical protein FLJ11090	5.28E−04	1.01
448778	AF074913		gb: Homo sapiens transcription factor Pax	8.48E−03	1.01
400425	AY004252	Hs. 287385	PR domain containing 12	3.58E−06	1.01
438326	AW575901	Hs. 123230	ESTs, Weakly similar to Z195_HUMAN ZINC	9.93E−04	1.01
439698	AW779654	Hs. 55876	ESTs	3.98E−03	1.01
419189	T95862	Hs. 112318	6.2 kd protein	5.70E−03	1.01
436407	T88803	Hs. 237517	ESTs, Weakly similar to TIM_HUMAN PROBAB	3.93E−04	1.01
414630	BE410857	Hs. 16064	gb: 601301177F1 NIH_MGC_21 Homo sapiens c	9.04E−03	1.01
409294	BE546175	Hs. 71746	hypothetical protein FLJ11583	2.83E−03	1.01
450184	W31096	Hs. 237617	Homo sapiens, clone IMAGE: 3447394, mRNA,	8.64E−04	1.01
457771	AI814635	Hs. 187117	ESTs	3.92E−03	1.01
451595	AW965569	Hs. 20996	ESTs	4.46E−04	1.01
416559	AI039195	Hs. 128060	ESTs	6.29E−03	1.01
453680	AL079647	Hs. 14485	Homo sapiens cDNA: FLJ23220 fis, clone A	5.45E−03	1.01
424365	AI653164	Hs. 128665	ESTs, Moderately similar to I54374 gene	4.16E−03	1.01
419357	AW955121	Hs. 55148	hypothetical protein FLJ14466	6.12E−04	1.00
450991	AI751020	Hs. 313648	gb: cnO7g05.x1 Normal Human Trabecular Bo	5.11E−05	1.00
419861	AW081795	Hs. 233465	ESTs	4.72E−03	1.00
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: T-test p-value
R2: Difference of the average standardized value of Hep C− Liver vs. the average standardized value of Hep C+ Liver

[0369]

TABLE 12B
Pkey	CAT Number	Accession
454947	1083824_1	AW846590 AW846615 AW846584 AW846592 AW846621 AW846610
455765	6676_13	BG620787 AV761949 BG980132 AV761951 BE082222 BG979177 BF329571 BF908591 BE082279 BE081722 BG978604
455919	1527074_1	BE157195 BE157345 BE157130 BE157368 BE157136 BE157134 BE157202 BE157305 BE157109 BE157294
		BE156971 BE156997 BE157374 BE156970 BE157366 BE157356 BE156973 BE157358 BE157300
412998	1343218_1	BE046254 BE046673 BE046253
417574	2134673_1	R00348 R09593
456636	433615_1	AW954166 AV723710 AW014769 AA916838 AW205448 AA476474 AI214918 BE550871 AI299143 AI685787
		AI810480 AA476475 AI681494 AI378542 BF222633 AA769645 AA299751 AA299752
409840	915929_1	AW502122 AW501663 AW501720 AW502125
432745	112643_1	AA658826 AI821926 AI791191 AA635129 AA564492
454810	1073338_1	AW832915 AW832906 AW832788 AW832917 AW832776 AW832913
411772	300555_1	BE154090 AW861539 BF921665 BF350632 BF350631 AW904851 BE170301 BE154336 BE154275
407457	24680_1	AB044546 AJ242724 BF760529 BF946992 BG983676
450703	35938_2	AK056299 AI669104 AI378016 AI420515 AW297177 AI702739 AA889785 AA011202
436871	57685_1	AA070431 AA121992 AA076561 AA080879
459235	26808_3	AW814516 AW815927 AW814504 BF375203 AW814522 AW814521 AW814524 BF375206 AW814518 AW814517
		AI940652 BF837881 AW751232 BF374342 AW176453 AW814505 BF886651 AW814525 BG001382 BE933380
426505	1139_4	BG177042 BE185582 BE185655 BE185657 AA380194
423053	367623_1	BE314223 AA320990 BE312679 BI054000 BI324838 AW057717
444163	682245_1	BG403189 AI148521 AI184746 AI126098 R05933 BI057330
440730	1648529_1	BE561722 BE268773 BE268956
447721	1889_2	BC013767 AL572931 BE742185 BI520113 AW959076 AI341487 AI623222 BM091074 AW593800 AI983635 AW275114
		AI952164 BM091378 AA977038 AW513859 AI801910 AW273202 AW166266 AW337946 AI086791 BE907359
		AW273147 AI453134 AA250733 AW072844 AI818468 AI561259 AW470887 AW300481 AW103087 AW175624
		BE048584 BF063936 AI207341 AW193240 AW193322 AW264492
		AI682412 AI631778 AI669677 AI128695 AA448630 AA456607 BF313680 BG898294 BI195544 BG421755
		BI760100 BE383304 BF329916 BF526599
		AA385255 BI520887 AA410939 AA448721 BF525380 BG423666 BI761786 BF944570
455973	1561647_1	BF352282 BE175424 BE175418 BE175383
454707	1067650_1	AW814808 BG999545 AW814989 AW814852
452621	2071061_1	AI910230 AI910262 AL134108 N44030
419555	252042_1	AA244401 AA244416
451402	1958047_1	AI793167 H39479
434646	15463_1	AF147445 AA130804 AA069114 AA069113
409795	MH905_27	AI498073 AI934808 AW374654 BI036066 BE709215 AA077985 BI831355
		BF932450 BF770705 BF379220 AA077682
		AA076814 AA076875 BI027970 AA077787 AA077311 BF811798 AW393752 BF327269 AA077305 AA078114
		BF800885 BF942930 AW903223 BF916052
		AW903170 AW903224 BF352664 BF379209
442793	417820_2	BG741247 BG741022 AI017798 AI953594 AW445065 AI245087
413537	1375441_1	BE146866 BE146865 BE146867
455968	1557068_1	BE168828 BE168823 BE168830 BE168820 BE168931 BE168826 BE168928
416648	1982787_1	R97488 H71377 R97368
458867	1246993_1	AW995393 AJ403118
425526	1076747_1	AW962995 AW955306 AA359933 AA358889 AW837746 BG961280
		AW837697 AW837755
408099	7104_17	AW151646 AW151645 AW151637 BI562740
434884	10696_1	AF161340 AF150140 AV738842
438687	2575583_1	AI674070 AI239526 AI240515 AA814084
441184	1816784_1	BE715995 BE715973 AI204080 AA954474 AA922009
410312	1001291_1	AW851102 AW851181 AW850953 AW851110 AW629671
423103	879332_1	BE315237 AA322029
447135	579607_1	T58148 AW516579 AW059603
426254	7308_1	BC017081 AL539521 AL524509 AL556058 AL541690
		AL543200 BF974751 BE514793 AW247083 BE183238 AA376427
		AF202637 NM_022156 BI554151 AL559157 BE909859 AW009244
		AW043786 AW273850 AI871111 AI889050 AL045428 AI884485 AI554001
		AI375841 AI469097 BF741351 AW188439 AA410448 AW515248 BE301590
		AW007777 AI148210 AI805423 BE784190 AV658045 AI093347 AI308976
		AI249682 AI206484 AI493895 AA973765 F29582 AA335219 AA379270 F37119
		AA026496 BE645159 AA617996 AI886986 BM144558 BC003659
		BG739795 BE729530 BG334810 BE746857 BE390302 BM354208 BF757460
		AA284639 AW967315 BE769162 W96068 BM477081 BG490980 BM013665
		BE735761 BE257483 BE257427 BG255544 AI474585 AL569826 BG337562 BG491737
		AL559158 BG822257 AL554642 AL570587 AA588594 AL041071
		AA554020 AA287274 AA810799 AA729332 AA659019 BE439973 AA335218 AA639556
		AA610680 R16774 H26778 AA026419 AA010840 BF830072
		R50167 AL577377 AA622659 F25241 BF880480 AA872445 BE386621 AL571579
415160	1861867_1	T82802 R08505 D78670
416397	1969080_1	T91431 H80874 H53035
412371	1172992_1	AW946709 AW946621 AW946699 AW946695 AW946691
		AW946697 AW946666
416323	1964997_1	H47929 N78108 N72630
412433	413465_1	AV698615 AA102400 AA327633 AA102401 AI970895
455663	1490406_1	BE065460 BE065619 BE065633 BE065626 BE065679 BE065617
433010	1234715_1	AW970018 BE843649 BE843644 AA573622 R08736 AA573669
422800	11320_9	BE545343 AW997954
414648	316607_1	BF126232 H54463 BF950132 H54381 BF944624 BE393262
437093	325853_1	BF955573 AA744334 AA745434 AA744302
445481	504944_1	AW003346 AI808038 AI671563 AI240190 AW661846 AI286080
410922	1064329_1	AW810845 AW810831 AW810661 AW810816 AW810772 AW810666
		AW810865 AW810859 AW810670 AW810805 AW810856
		AW810819 AW810852 AW810722 AW810699
412044	1149589_1	BE086167 AW887835 AW887682 AW887677 BE178621
		AW887676 AW887674
448464	661708_1	AW196419 AI522053 AI650395
432909	137712_1	AA702596 AA570111 AI348435 AW192161
415597	1876403_1	T74345 F12588 Z44384
440075	1648556_1	BE559806 R12767 BE268806
441194	138512_1	BE275382 AA703515 BE166690 BG334067
432092	34124_1	AA583908
454537	15351_6	BG421219 BI488939 BE391114 BE391493 BG764533
		BE276157 BE388289
446403	488811_1	BE549932 BE467906 BE326357 BG149226 AI298565
		AW452904 AW449414 F04362
441662	2674073_1	AI807406 AI798919 AA948548
411154	1071475_1	AW819848 AW819850 AW819863
448544	1139239_1	BM476470 AW902443 AI535819
430725	1597397_1	AI478920 AI478907 AA485056
422579	15032_4	BG035571 BM457635 AA312626
432081	1237080_1	AA525888 AA525391 AA984238 AW972788 BE087083
453196	505145_1	AW003567 AI963955 AI990231
421798	3042_4	BC017829 AW276646 AI984209 AA663933 AA634104 AA551528
		AA634041 AA298038 BG483990 T89297 BF853958 H64685
		T90329 T60644 T57747 BF852694 T92529 BG482852 BF883064 BF883066 N74880
		AA829796 N90716
454803	1072913_1	BI468492 AW862380 AW860148 AW821887 AW821863
		AW821894 AW821870 AW862378 AW862351
413619	1524553_1	BE153524 BE153576 BE153583
428177	8737_7	AA779866 AA423967 AA423968
411288	1074988_1	AW835517 AW835513 AW835511
418551	2261897_1	AL564778 R99167 T99393 T75517
415449	1873127_1	H15034 T17195 F09069
457677	1205688_1	AI374612 AA628890
454908	1078884_1	AW840458 AW840400 AW840401 AW840535 AW840539
		AW840532 AW840538
413737	1551611_1	BE160704 BE160849 BE160896 BF351011
454186	645362_1	BE141775 BE141030 BE141467 BE141520 BE141028 BE141492
		BE141477 BE141460 AW177599 BE141456 BE141753
		AW177597 AW177582 AW807582 AW177585 BE141761 AW177598 AW177579 AW177583
		AW177587 BE141749 BE141489 BE141474 BE141512 BE141751
		BE141024 AW177581 BE141750
413961	566812_1	BG251042 BE266372 BE207098
454598	1063474_1	BF374577 AW809840 AW809996 AW809798 AW809695 AW809646
		AW809738 BF374582 AW809716 AW809826 AW809802
		AW809747 AW810152
417313	1943_33	W01148 AA195602 N40632
410285	2930719_1	AA083790 AA083609 AA112048
408432	288076_1	AW811262 BF905430 BF908283 BF368183 BF907357 BF908452
		BF908282 BG001786 BF908281 BF907042 BF908278 BF908277
		BF908451 BF368225 BF379361 BF907348 BF908280 AW195262 R27868
449405	78886_1	AA203114 R00660 H83070 AA001350 H70366 R95157
431357	1235874_1	AW971393 AA503896 T81154 AA507148
428568	738084_1	BE259137 BE251523
415037	980243_1	AA159478 AW901089 AW593155 AA160437
440190	1030220_1	AW848781 AW848490 AW849062 AW752597 AW752699
458146	114488_2	AW589833 AI652176 AI216328 AI286094
409975	926611_1	AW839324 AW516213 BE142635
419299	36328_1	BM477587 BE675426 AA827059 AI597639 AI571409 AI719948
		AI311085 AA953361 AI498787 AI364049 AI311084 BF871020
		BF549868 AI356384 AA236660
400111	24179_2	NM_006156 D23662 BF038671 BI670321 BI603145 BI666956 BG716628 BG707476
		BG768814 BE312007 BF125930
		BF037916 BG942671 AI752472 AW009362 BE379126 BI198555 BF126026 N28289 BE388301 BG327102 AI571450
		BF038400 AI884649 AI718962 AI742314
		AA977058 AI150699 BG944784 AA187402 BG283893 AV712007 W01301 BG774109 W77840 C15672 BI670016
		AI752473 AA484409 C14921 N41745 C15220
		F30164 AA133181 BF768974 H30334 AA034968 AA384232 AA353297 AW407023 AA337516 F36177 AA374444
		AA402758 AI141545 BI021470 AA973914
436375	46760_1	AJ227870 AW798823 AW798704
409818	914614_1	AW502932 AW500969 AW501134 AW501533
453741	1031156_1	AL120304 AW855522 AW753631
439665	24497_1	AF086498 AW955697 W93979 AI936062 AW268568 AA364461 W93980 BI914847 BI523483
455977	1562520_1	BE176686 BE176477 BE176484 BE176679
457424	117833_1	BM041161 BM040921 BM040887 AW876082 AA513157 BM041809 BM041314 AA747408
		AA747397 AA736702 AA745146 AA648638
430204	MH1094_26	AI821606 AI826629 AI304327 AI660560 AW050605 AI732165 AW009962 AI262416
		AI695625 AA469031 AI791844 AA573825 AA618335
455638	1489140_1	BE142908 BE063665
450799	819959_1	W31274 AW407504 AI738877
444207	9172_3	BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464 AA514889
		AW819039 AW819083 BE843048 AI432496
		AI470335 AI247243 BG533994 AA513783 AI887309 AA528036 AW972006 AW873028 AI924914 AI818810
		AW152378 AW084946 AI521413
		AI669583 BE932521 AI581370 BE180238 AW089750 AW771461 AW089714 AI590949 AI819148 AA731056
		BF815234 BF911506 AA235803
		AA485373 AI735658 AW393133 AW073080 AI707637 BF353320 BE843111 AW819036 AW393135 BG697291
		AV648670 AV654332 AV687530
		BG566964 AI807430 AI676072 AA837010 AI452482 AI625817 AW241750 BE048616 AI290928 AI680714 AA485530
		BE175687 AV648513
		AW130312 AI000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 AI244948
		AA602956 AA483492 AA918178
		AW802049 BG675859 AV658871 BG678060 AI565004 AW819026 BE843092 AV686437 AV723049 BG616948
		AI911647 AI743490 AI091096
		BE857251 AI962074 AA049027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095
		BE843140 BG536641 BG617830
		AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 AI749532 BE768614
		BE857252 BE932516 BE768573
		AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793 BE180119 BG617338
		H45942 T55897 AV657718 BG563497
455194	1107901_1	AW947513 AW864536 AW864318
413309	455217_1	BF315003 BE312608 R10565
416115	863707_2	BE147652 BG990288
437216	645_11	R61679 AA746905 H13364 BF185622 N29108
438327	18001_1	NM_033183 NM_033043 NM_000737 BC006290 J00117
		BG479175 AU138071 AI188721 AI188454 AI188947
		AI188781 AI188729 AI200658 AI148857 AI188639 AI209155 AI189616 AI189595 AI189275 AI192447 AI188604
		AI200457 AI188391 AI184224 AI190013 AI189641
		AI207360 AI148695 AI148590 AI149163 BF589174 AI188348 AI189842 AI188498 AI148904 AI138197 AI417614
		AI126101 AI160579 AI160936 AI160814
		AI123896 AI189442 AI149591 AI131286 AI138448 AI149559 AI128296 AI168482 AA330755 NM_033142
		AI192459 AI741512 AI206390 AI186215
		AI148647 AI189807 AI183280 AI200559 AI188964 AI188303 AI200022 AI186353 AI219044 AI200270 AI189555
		BG200016 BG210411 AI186465
		AI186218 AI189968 AI149039 AI273580 AI291937 AI276216 AI188689 AI157454 AI200375 AI184348 AI221605
		AI871881 BF432300 AI128424
		AI868741 AI219133 H93668 AW451899 H95381 C18834 AA331267 AA330978 AL548158 AI149571 AI149072
		AU155932 R68113 R26086 AA330414
		AL551303 AI188830 AI188824 AI206355 AI453626 AI189364 AI160692 AI189068 AI219266 T49171 AA330939
		AI130720 AI151301 AI199943
		AI221019 AI186330 AI149467 AI198460 AI220923 AI161082 AI654493 AI184784 AI219589 AA232905 AI160705
		AI189453 T47334 N30758 K03181
		AL551349 BG434672 N40745 N41758 T83001 R71610 AA331230 N39958 AA330844 BE901661 AU135260
		H86992 H87407 AA330968 AA330717
		AA330761 AU139360 N42631 AA333923 AA330974 BG435249 AA331021 AA331049 N41851 AA330831 R23289
		H87658 AA331043 AA330803
		AL548120 BG479085 AA330609 AA331023 AA331039 BE733206 BE732062 W76381 R63351 BF060995 N56715
		N56709 N40038 T52077 N41710
		H94535 BI088367 N41834 H94543 AA330643 N47829 R23494 BG434117 N42013 R68922 AA331012 N40479
		D78974 R67480 H56737 N40793
		N41357 N41591 N41596 H93655 R68162 H87630 T85052 R01541 AI219422 AI221014 AI219055 AI221580 AI220780
		T28278 AI219166 AI220865
		N27381 N27073 N41361 N42190 N57328 AI149426 N57248 H86986 W71989 N30684 N30822 T85053 AI188728
		AI168533 H95374 H94451 T49170
		BF369834 N29831 N31955 N30313 N32233 AI221552 AI126906 AA400910 T90191 R23214 AI138431 AI128407
		AI188492 AI186418 BF109879
		N26397 AI188872 AI149447 N30216 AI431595 AI219009 N30817 N30833 AI148774 AI188715 AI149156 BG774563
		H95176 H94991 H94347
		N32759 N32604 H12587 H93656 H94015 N29701 N30276 N27302 BF999045 N29730 R68815 H87631 H86993
		R63352 H95135 H94446 H87464
		H95207 N31616 NM_000894 AV751658 AV752236 AI051683 AV748886 T29543 AA371971 AA371978
		AA371346 AV753384 AA372026 AA371909
		AV745740 AV746068 AV751144 AV747923 AV745447 AV748231 AV745712 AA063496 N56646 H87574 AW951441
414182	2917943_1	AA136321 AA136301 AI381776
409382	110743_1	AA071477 AA071244
452947	625171_1	AI932362 AW130413
411507	1088866_1	AW850140 AW850195 AW850192
412419	1175957_1	AW948630 AW948616 AW948604 AW948623 AW948627 AW948611 AW948605
		AW948610 AW948626 AW948634
		AW948631 AW948615 AW948607 AW948602 AW948633 AW948628
428680	41659_1	AB075857 U69199 AL554057 BE550443 AI125387 AI125388 AI372992 AI686618 AA583075
		AW079720 AI948894 AI342763
		AI982591 AW779115 AI560632 BF001153 AI623930 AA447536 BG911172 AA480680 BI197703 BE294318 AL530842
		AL562327 AA448518
		AA432018 BE264771 BE259722 BF930927
430820	32425_1	AF194815 AF194816
415016	1806690_1	N62934 BE858324 N46417 N46363 N46427 N46358 D19793 H99021
459233	3170768_1	AI939966 AI939976 AI939951 AI939981 AI939959 AI939988
424324	808543_1	AW954536 AA338802 BE160193 AA346316
422388	870372_−1	BE061034
424397	893246_1	AI950320 AA340023
418784	2306231_1	T41418 T41379 T41320
412682	1242945_1	AW983772 AW983837 AW983730 AW983769 AW983836 AW983835
413772	1553630_1	BE163499 BE163572 BE163580 BE163565 BE163503 BE163510
433299	1752_1	AK056027 AL120636 AA582324 AA582305 AI459497 BI047007 AL589306 AI688987
		AI922469 AA350721 AI085972
		AF131844 AW954598 AW957578 AA350710 AI884831 R37119 AA666294 AA350709 BF724097 AA203665
		AI089250 AA708285 BF831652
		AW104744 AW104745 AW129091 AV724110 AW805934 AV682207 AA563965 W93840 AW104743 AW009432
		AI085993 BF839379 T79879
		BC019656 AA975816 AI953836 BE350274 AW840298 BI043880 BG913327 AW839960 T07306 R53951
		AI299256 AI961918 AI190874 AA724491
		F04512 BG997879 R08567 BE810546
414205	1266364_1	BF306238 BE295439 BE382708 BE383262 BF315437 BI199567 BE382438
454397	118552_1	AW974648 AA649671 AA652153 BF875948 AA078582
409487	815197_1	H19886 T10231 AW402806
431151	1570517_2	BE207083
419017	2348209_1	T83961 T79425 T85415 T79511
436234	141336_1	AW269942 AI809027 AI799097 AA707010
413042	1487648_1	BE061618 BE061640 BE061619
454065	517162_1	BE394588 AW024754 BE183167 BE183166 BE378353
433821	72553_2	AK054648 AW182416 AA609856 AA918195 AA634398 AA927922 AA868718
		AI290470 AI338870 Z25302 T30841
		T30825 F29302 AA436128 BF095986 BI829584 AA853991 AA778707
448401	507788_1	AW007014 AI498509 AW156947 AI933042 AW370727 AW370779 AW370731
		AW370726 AW370764
408278	MH337_68	BG422281 BG422108 AW177973 BG750536 AW876813 AW876814
412139	1154826_1	AW895327 AW895462 BE044976
412474	1022404_1	BE296601 BG829182 AI791451 BE019234 AI791288 AA111939 BG954837
438998	52228_1	AF075064 R89255 R89256
459375	619648_−3	BE251770
458318	1561764_1	BE177830 AF114068 BE175531 BE175603 BE175601 BE177658
455932	1528183_1	BE158451 BE158453 BE158585 BE158584 BE158454 BE158465 BE158464
408690	105725_1	BG563152 BF846777 BF849354 BF849359 BF846636 BF849201 BF849356
		C16931 AA056717 AW864542 AW882724
		AA056567
448778	7800_1	AW505435 U62539
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0370]

TABLE 12C
Pkey	Ref	Strand	Nt_position
404473	8079921	Plus	22639-22773
402845	9369286	Plus	160451-160617, 160788-161009
400692	8118799	Plus	37906-38256
404224	6002294	Minus	80109-80957
405800	2791346	Plus	19271-19813
401149	7229925	Plus	73117-74019
405334	3135285	Plus	139386-139856
404958	7407941	Minus	2731-4531
405058	7655685	Plus	150740-151556
400663	8118474	Plus	88985-89281
403686	7387348	Minus	66625-68364
402399	1905915	Minus	24502-24666, 24986-25102
401624	8575907	Plus	168318-168444, 172964-173647
401706	4826475	Minus	14767-15317
405263	7329364	Minus	104082-104796
403796	8099896	Minus	75073-77664
405639	5091650	Plus	211184-211350
403794	8096910	Plus	163292-163884
403772	7770492	Plus	117668-117899
405126	8316124	Plus	45650-45911
400729	6705887	Plus	117048-118826
403243	7637828	Minus	76343-76585
402690	8348058	Plus	13368-13998
405677	4567140	Plus	31045-31445, 31688-31885
400522	9796828	Plus	40475-40792, 41517-41813,
			42598-42894, 4325
406140	9168231	Minus	49887-50219
401371	9650602	Plus	80901-81283
406357	9256093	Minus	77181-77415
401554	8099284	Minus	153483-153612
405137	8570507	Plus	158969-159423
404843	7940338	Plus	22556-23222
403613	8493504	Plus	81290-81465
402534	9801061	Plus	58989-59457
401629	8575965	Minus	169336-169788
404731	7230299	Minus	168609-168781, 182951-183081
404219	1841541	Plus	50866-51013, 51517-51614,
			51788-52030
405913	7712139	Minus	7484-7678
403180	7523976	Minus	63603-63759
401595	3293210	Plus	58192-58362
406089	9123919	Plus	73784-74296
401899	7230209	Minus	155620-155815
402137	7704985	Plus	11434-11799
404701	9800167	Minus	60061-60180
403474	9957921	Plus	55961-56511
405762	5931935	Plus	160502-161110
405590	6960456	Plus	90492-90818
404825	6478944	Plus	210382-210494
402638	9958128	Minus	82748-83226
406458	9756020	Plus	145874-146911
404923	7341893	Plus	98418-100223
403209	7630841	Minus	60664-60810, 85748-85939
400635	8567750	Minus	102800-102932, 107482-107689
402349	8191067	Minus	6817-6994, 7340-7680
402951	9408717	Plus	73252-73329, 73718-73877,
			76217-76299, 7819
402447	9796640	Plus	47605-47729, 51696-51821,
			52070-52257, 5330
403545	8078400	Plus	25293-25640
402561	9864675	Plus	72967-73163
401516	7637251	Plus	62335-62502
405691	4508112	Plus	171350-171739
404126	9796876	Plus	48919-49155
404046	3688074	Minus	2-773
402991	7631064	Minus	161294-161579
402320	7630359	Minus	46058-46153, 46446-46572
403227	7637789	Plus	24457-24771
401265	9797154	Plus	135413-135573
404247	7406725	Minus	83949-84214, 84312-84415,
			84499-84677, 8487
404247	7406725	Minus	83949-84214, 84312-84415,
			84499-84677, 8487
406370	9256130	Plus	125320-125482
404075	7652011	Plus	53692-53938
401703	4826475	Plus	135-1229
402252	3548788	Plus	6848-7049
402316	7527774	Minus	10751-10919, 18817-19052,
			22131-22328
400818	8569994	Plus	172644-172765, 173085-173200
404900	7331453	Plus	22032-22219
400877	9857603	Minus	156938-157254
402610	9926549	Minus	22955-23124
404769	8099713	Minus	175801-176823
402863	2956660	Minus	29506-29693
402012	7407997	Minus	111771-111909, 112107-112226,
			112519-11269
402411	9796294	Minus	109449-109598, 111328-111478
403567	8101141	Plus	35349-35614
401831	6850361	Minus	107181-108077
403248	7656833	Minus	167439-167606
402190	8576067	Minus	76488-76959
402878	9908870	Minus	56133-56522
401008	8117391	Minus	81421-81551, 82364-82512,
			82862-82938
401037	7232177	Minus	3364-3686
404187	4481839	Plus	7644-7991
402869	6434643	Minus	138639-139335
404504	8151759	Plus	83050-83765
405593	6960456	Plus	157746-158046, 160760-160939
402255	3510233	Plus	9421-9621
406146	8746393	Minus	28514-29086
403722	7528070	Minus	117448-117615, 120977-121188
404805	4165236	Minus	37584-38304
403830	9887814	Minus	20687-20893
404909	7331453	Minus	123713-123909, 124327-124411,
			124511-12462
401450	4680764	Minus	59252-59334, 59945-60427
405316	3638954	Plus	76171-76417, 76692-76844
404364	9964977	Minus	32986-33202
406138	9166422	Plus	42227-42753
402338	6957691	Minus	36915-37250
404244	5672609	Minus	98173-98517
402124	4033680	Plus	164206-164459
400470	9930824	Minus	156245-157227
406279	7547249	Plus	203752-204426
402635	9958100	Minus	167621-168379
401532	7798785	Plus	124414-124950, 125050-125418
403358	8570101	Minus	106778-107580
402517	9798106	Plus	17569-17721
400576	7923997	Minus	91711-91954
404907	7331453	Minus	102880-103828
400765	8131622	Plus	35000-35306
405201	7230116	Plus	36934-37314
405282	3810573	Minus	10482-10689
402022	7139714	Plus	165595-165748
403579	8101179	Minus	36167-36365
403957	8076835	Minus	81649-81754
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0371] Table 13A lists about 102 genes up-regulated in Hepatitis C positive liver tissues from patients that are non-responsive to pegylated-interferon-alpha plus ribavirin treatment (non-responders) compared to Hepatitis C positive liver tissues from patients that are responsive to the treatment (responders). In both cases, the liver biopsies were obtained prior to treatment. These 102 genes have potential to be diagnostics and/or prognostic markers for determining the responsiveness of Hepatitis C infected liver tissues to pegylated-interferon-alpha plus ribavirin treatment. They may also provide clinical information on Hepatitis C infection and pathology. They may also be potential targets for therapeutic drugs and/or treatments. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the t-test p-value between the non-responders liver tissues group and the responders liver tissues group was less or equal to 0.01, and that the differences between the average “standardized values” of the different non-responders liver tissues was equal to or above 1.0 more than the average standardized values of the different responders liver tissues. The “standardized values” of the Hepatitis C liver tissues were derived by subtracting the median of the several different Hepatitis C negative liver tissue values from each probeset value, then divided by the interquantile range (IQR) of the same several Hepatitis C negative liver tissue values.

TABLE 13A
Pkey	ExAccn	UniGene	Unigene Title	R1	R2
440495	AA887212	Hs. 14161	hypothetical protein DKFZp434l1930	4.81E−03	4.71
439242	BE167324	Hs. 53996	ESTs, Weakly similar to ZN42_HUMAN ZINC	1.71E−03	4.63
437855	AA776740		ESTs	2.88E−03	4.12
413321	BE082938		gb: RC2-BT0642-290200-016-b02 BT0642 Homo	9.87E−03	3.29
453696	AI989482	Hs. 146286	kinesin family member 13A	7.86E−03	3.05
452455	N25153		ESTs, Weakly similar to AF174605 1 F-box	5.32E−03	3.04
455348	AW901517		gb: RC5-NN1013-310300-021-C03 NN1013 Homo	3.47E−03	3.00
459577	AA019148		gb: ze56e02.r1 Soares retina N2b4HR Homo	5.46E−04	2.90
446633	U85996	Hs. 157142	ESTs, Weakly similar to I38022 hypotheti	6.87E−03	2.90
434848	BE256304	Hs. 32148	AD-015 protein	2.06E−04	2.78
452941	AL110347	Hs. 31074	N-sulfoglucosamine sulfohydrolase (sulfa	2.47E−03	2.76
407544	Y10206		gb: H. sapiens mRNA for CD64 protein.	2.28E−03	2.70
450578	AI971773	Hs. 232268	ESTs	3.64E−03	2.68
439774	AL360257	Hs. 213493	Homo sapiens mRNA full length insert cDN	4.81E−03	2.66
436427	AI344378	Hs. 143399	ESTs	4.46E−03	2.60
413348	BE086846		gb: QV1-BT0678-300400-182-b06 BT0678 Homo	2.15E−03	2.58
415210	Z25274	Hs. 154706	hypothetical protein FLJ14917	8.96E−03	2.49
403512			C3000579*: gi|12643308|sp|Q9Y4K1|AIM1_HUM	8.08E−03	2.49
425225	NM_003450	Hs. 155204	zinc finger protein 174	6.11E−03	2.49
422258	AI910976		gb: wd22a06.x1 Soares_NFL_T_GBC_S1 Homo s	5.28E−03	2.46
420400	AI337097	Hs. 156902	ESTs	5.73E−03	2.37
411729	AW861879		gb: CM0-CT0341-260100-160-h12 CT0341 Homo	2.55E−03	2.35
443933	AI091631	Hs. 203845	two pore potassium channel KT3.3	2.27E−03	2.30
449137	AW134478	Hs. 196033	ESTs	8.66E−04	2.28
431498	AK001777	Hs. 258551	aspartyl aminopeptidase	4.39E−03	2.28
444811	AW137791	Hs. 148419	ESTs	1.97E−03	2.28
457365	AA577297	Hs. 303249	EST	4.58E−03	2.27
409198	L19778	Hs. 51011	H2A histone family, member P	1.64E−03	2.19
430144	AI732722	Hs. 187694	ERGL protein; ERGIC-53-like protein	3.29E−03	2.16
420803	M91556	Hs. 99945	sodium channel, voltage-gated, type VI,	6.76E−03	2.16
411504	R90961	Hs. 164584	ESTs	9.64E−03	2.07
428291	AA534009	Hs. 183487	interferon stimulated gene (20 kD)	2.28E−03	2.02
422211	R84341	Hs. 293845	Homo sapiens, clone IMAGE: 3502329, mRNA,	6.74E−03	2.00
453746	AL120611	Hs. 107924	gb: DKFZp761H119_r1 761 (synonym: hamy2)	1.78E−03	1.99
454278	AF217525	Hs. 49002	Down syndrome cell adhesion molecule	1.53E−03	1.96
447281	AA017018	Hs. 18021	hypothetical protein FLJ20446	1.41E−03	1.94
452399	BE513301	Hs. 29344	hypothetical protein, clone 24751	1.86E−03	1.94
426150	NM_003658	Hs. 167218	BarH-like homeobox 2	6.19E−03	1.93
406773	AA812424	Hs. 76067	heat shock 27 kD protein 1	1.01E−03	1.93
430259	BE550182	Hs. 127826	RalGEF-like protein 3, mouse homolog	4.72E−04	1.92
431368	AA760776		ESTs	1.90E−03	1.91
413201	BE275378	Hs. 13972	hypothetical protein MGC12972	6.19E−03	1.91
408893	AW605335	Hs. 288826	Homo sapiens cDNA FLJ12263 fis, clone MA	8.42E−03	1.90
454521	AW803516		gb: IL2-UM0081-230300-053-B12 UM0081 Homo	6.83E−03	1.89
405419			CX001144*: gi|7242973|dbj|BAA92547.1|(AB	5.89E−03	1.88
403005			C21000027*: gi|1817556|dbj|BAA13672.1|(D	3.44E−03	1.84
454282	AW296422		gb: UI-H-BW0-aio-h-05-0-UI.s1 NCI_CGAP_Su	7.45E−03	1.84
449381	AW388688	Hs. 288217	hypothetical protein MGC2941	7.54E−03	1.83
443305	AI050693	Hs. 133318	ESTs	9.26E−03	1.81
455154	AW859359		gb: MR1-CT0353-150300-102-c02 CT0353 Homo	8.62E−03	1.79
408172	W02488	Hs. 46039	phosphoglycerate mutase 2 (muscle)	9.27E−03	1.78
452711	AW967047	Hs. 293224	ESTs, Weakly similar to T00375 hypotheti	1.61E−03	1.70
448279	BE250564	Hs. 283655	lysophospholipase II	9.00E−03	1.67
408771	AW732573	Hs. 47584	potassium voltage-gated channel, delayed	3.00E−03	1.62
445909	BE262656	Hs. 32603	hypothetical protein MGC3279 similar to	6.81E−03	1.61
445058	AA234031	Hs. 326104	putative mitochondrial solute carrier	8.61E−03	1.60
442620	C00138	Hs. 8535	Homo sapiens mRNA for KIAA1668 protein,	8.16E−03	1.59
431369	BE184455	Hs. 251754	secretory leukocyte protease inhibitor (	1.85E−03	1.58
441307	AW071696	Hs. 209065	hypothetical protein FLJ14225	1.73E−04	1.56
435012	AA768359	Hs. 149452	ESTs	7.59E−03	1.55
447606	AI588954	Hs. 170995	ESTs	7.61E−03	1.55
432911	AW807634	Hs. 279799	putative zinc finger protein NY-REN-34 a	9.38E−03	1.54
450812	AB002360	Hs. 25515	MCF.2 cell line derived transforming seq	2.25E−03	1.52
441164	AB023180	Hs. 7724	KIAA0963 protein	7.60E−03	1.52
455749	BE075035		gb: PM3-BT0584-260300-002-g05 BT0584 Homo	2.33E−03	1.51
412732	AW993300		gb: RC2-BN0033-180200-015-g06 BN0033 Homo	4.33E−03	1.49
414056	AI187349	Hs. 17681	ESTs	6.51E−03	1.49
458765	AI419235	Hs. 344456	gb: tf21d02.x1 NCI_CGAP_Brn23 Homo sapien	2.19E−03	1.44
407496	U20648		gb: Human zinc finger protein (ZNF154) mR	6.69E−03	1.42
434415	BE177494		gb: RC6-HT0596-270300-011-C05 HT0596 Homo	6.67E−03	1.39
407233	X16354	Hs. 50964	carcinoembryonic antigen-related cell ad	8.97E−03	1.38
410020	T86315	Hs. 728	ribonuclease, RNase A family, 2 (liver,	4.92E−03	1.37
454303	AW857169		gb: RC1-CT0302-110500-018-f10 CT0302 Homo	3.89E−03	1.34
401411			ENSP00000247172*: HYPOTHETICAL 126.2 kDa	5.91E−03	1.33
444754	T83911		transmembrane 4 superfamily member 4	6.61E−04	1.32
446411	AI298828	Hs. 153439	ESTs	1.63E−03	1.30
428407	NM_003963	Hs. 184194	Transmembrane 4 superfamily member 5	5.64E−04	1.30
452910	AI927371	Hs. 288839	hypothetical protein FLJ12178	9.89E−03	1.29
435791	AA243086	Hs. 25204	chondroitin 4-O-sulfotransferase 2	4.10E−03	1.29
441504	BE159181	Hs. 168232	hypothetical protein FLJ13855	5.78E−03	1.29
456477	BE550252	Hs. 1295	calcium channel, voltage-dependent, alph	9.15E−03	1.28
446388	AA292979	Hs. 7788	NPD007 protein	4.50E−03	1.27
418863	AL135743	Hs. 25566	ESTs, Weakly similar to 2004399A chromos	8.80E−03	1.24
406684	X16354	Hs. 50964	carcinoembryonic antigen-related cell ad	9.58E−04	1.24
414784	NM_000344	Hs. 288986	survival of motor neuron 1, telomeric	7.19E−03	1.24
425429	U18009	Hs. 157236	membrane protein of cholinergic synaptic	8.57E−03	1.22
441252	AW360901		hypothetical protein MGC4399	6.93E−03	1.21
448222	AI648587	Hs. 20725	Mov10 (Moloney leukemia virus 10, mouse)	4.64E−03	1.21
414395	BE304888	Hs. 279834	EST	6.16E−03	1.20
441244	BE612935	Hs. 184052	PP1201 protein	2.70E−03	1.19
420886	AA805453		ESTs, Weakly similar to T29012 hypotheti	9.38E−03	1.18
444972	AW195642	Hs. 148901	ESTs	7.68E−03	1.18
417418	NM_002468	Hs. 82116	myeloid differentiation primary response	9.64E−03	1.18
427672	AA356615	Hs. 336916	death-associated protein 6	1.92E−04	1.17
451025	AW028689	Hs. 301985	ESTs	9.53E−03	1.16
407195	C21124		gb: HUMGS0002072 Human adult (K. Okubo) Ho	1.84E−03	1.14
437226	AA432308		Homo sapiens mRNA; cDNA DKFZp434M0420 (f	5.73E−03	1.13
407465	AJ401466		gb: Homo sapiens mRNA for high affinity c	2.51E−03	1.12
444751	AI207406	Hs. 11866	translocase of inner mitochondrial membr	8.36E−03	1.12
429396	AW954598		Homo sapiens clone 25015 mRNA sequence	5.46E−03	1.06
457097	AB037727	Hs. 334479	hypothetical protein DKFZp586I021	9.69E−03	1.05
440464	AI917706	Hs. 129997	ESTs	7.61E−03	1.02
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: T-test p-value
R2: Difference of the average standardized value of non-responders vs. the average standardized value of responders

[0372]

TABLE 13B
Pkey	CAT Number	Accession
437855	36765_2	AK056396 AI800037 AA777098 BF939153 AI621113 AA776740
		BF446127 AW295790 AA769865 AI690256 N32072 H55081 AL044298 AI286018
		BI044678 N45384
413321	1501922_1	BE083171 BE082893 BE082938
452455	928588_1	BE877195 BG988071 AI902576 N25153 AW518714 N25154
455348	1159211_1	AW901523 AW901517 BF363877 BF363878 AW901521 AW901547
459577	86256_1	W31316 AA019148 BF921026 BF921163
413348	1508017_1	BE086846 BE086726 BE086733 BE086849 BE086683
422258	868626_1	AW957794 AW957873 AA307574 AI910976 AA481204
411729	1099453_1	AW861879 AW861948 AW858447 AW861873 AW858418 AW861871
431368	331947_1	AW969020 AA760776 AA504117 AA731957 AA504375 BF962819
454521	1058686_1	BE154783 AW803516 AW803639
454282	725499 _1	H72616 H63825 AW296422
455154	1100782_1	AW859359 AW859373 AW859358 AW859368 AW859363 AW859370 AW859347
455749	1497012_1	BE075035 BE074999 BE075006 BE075008 BE075005 BE075032 BE075037
412732	1245294_1	AW993300 R22345 N23107
434415	110905_1	BE177494 AW276909 AA632849
454303	306545_1	AW857169 BF929104 AW857162 BE153976 BE141977 AW352163 BE141954
444754	2600_1	AK055577 U31449 NM_004617 BC001386 BE617218 BE868856 BM264336
		BG385990 BM353313 BI439041 BM272005 BM314705 BG616897
		AA345452 BM314731 AA345379 AA344984 BG191629 BF002707 BE138874 AI676255 AI675920 BM264034
		BI438713 BM314426 AW471424
		BF063338 BM311530 AW518986 BM314400 AI572072 AI337361 AW013983 AI569109 AW338459
		AA452917 AI572053 AI886493 R07511
		AA506545 AA480323 AA908761 AI921215 R11516 AI583063 AI584071 AW339205 AI640782 R85697
		AI784149 AI584060 AI566443 AI982840
		BI439748 H78445 H94341 BG210200 BI466960 BG197730 H59265 BG821834 AW951290 R96709 H90091
		T83911 T68523 R07564
441252	122_1	NM_032315 BC004991 BM468629 AL583162 BE741793 BE303031 BE244077
		BE302759 AL583161 AL572691 AI804708 AI129827 AW872388
		AI653103 AI151487 BE504355 AI671476 AW770976 AI206149 AI678224 BE468167 AI201164 AI200893
		AA574128 AI991968 AW194793
		AA426113 AI220474 AI201028 AA757281 AA844723 AA398466 AA484977 BF059403 AI470557 AA435830
		AW016602 AI915990 BF356355
		AL569855 AW978643 AW242882 AI823516 AW235374 BF059684 C20622 T66303 AI912746 AW339765
		AA968541 AL526958 BF433829
		AA628313 AW578403 AI909734 N75265 AW274422 W02124 BG474952
420886	56595_1	AK057268 AA281379 BI856491 AA805453 AA281414 BF373287
407195	1786254_1	AA569403 C21124
437226	2332_1	AL117642 BF056754 AI952151 AI953773 AL045835 AI041069 BF765693 BF765688
		BF763048 BG682692 AW967083 BM271900 AV704704
		AL040396 AI627368 AW514803 AI761270 AI015622 AI862541 AW197157 AI697779 AI568646 AI200936
		BE695042 AI366513 BE711314
		BE711324 BE047438 AW474529 AI421029 AL046814 AA400447 BF941647 AI143869 AW591727 BE695050
		BF887502 AW963918 BF001425
		AI340187 AW006934 AW468251 AW467398 AW516879 BF871799 AI816703 AI223153 BM264535
		AI624845 BE711307 AW514703 AW264118
		AW474488 BM263438 AW204628 BE711312 BE711330 AI718586 AI247201 BE711341 BF593534 AA626326
		AA747785 AA782029 AI341349
		AI921814 AW613873 BF332890 BE244575 BE694998 BF197632 AA609664 AW235441 BE042387
		AA704683 AA758933 AI970214 BI025187
		AA432308 BF871801 AW008470 BF765466 BE711329 BE711328 BF765463 BF765739 AW129408
		BF765015 BF764200 AL042362 H58451
		T86447 AA873427 AA570077 AW771950 AA400603 N69252 H16763 T65234 AA992089 AA836232
		AA813701 AA026623 W80716 AA861629
		N54181 N54185 AI015075 AA236563 R54957
407465	303_1	AB043997 NM_021815 AJ401466 AF276871 AV709773 AA364959
		AA363955 AA364965
429396	1752_1	AK056027 AL120636 AA582324 AA582305 AI459497 BI047007 AL589306 AI688987
		AI922469 AA350721 AI085972 AF131844 AW954598
		AW957578 AA350710 AI884831 R37119 AA666294 AA350709 BF724097 AA203665 AI089250 AA708285
		BF831652 AW104744 AW104745
		AW129091 AV724110 AW805934 AV682207 AA563965 W93840 AW104743 AW009432 AI085993 BF839379
		T79879 BC019656 AA975816
		AI953836 BE350274 AW840298 BI043880 BG913327 AW839960 T07306 R53951 AI299256 AI961918
		AI190874 AA724491 F04512 BG997879
		R08567 BE810546
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0373]

TABLE 13C
Pkey	Ref	Strand	Nt_position
403512	7656757	Minus	114487-114610
405419	4753290	Minus	60924-61120, 61641-61773
403005	5791501	Minus	16945-17053, 20018-20403
401411	7799787	Minus	144144-144329
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0374] Table 14A lists about 147 genes up-regulated in Hepatitis C positive liver tissues from patients that are responsive to pegylated-interferon-alpha plus ribavirin treatment (responders) compared to Hepatitis C positive liver tissues from patients that are not responsive to the treatment (non-responders). In both cases, the liver biopsies were obtained prior to treatment. These 147 genes have the potential to be diagnostics and/or prognostic markers for determining the responsiveness of Hepatitis C infected liver tissues to pegylated-interferon-alpha plus ribavirin treatment They may also provide clinical information on Hepatitis C infection and pathology. These were selected from 59680 probesets on the Affymetrix/Eos Hu03 GeneChip array such that the t-test p-value between the non-responders liver tissues group and the responders liver tissues group was less or equal to 0.01, and that the differences between the average “standardized values” of the several different responders liver tissues was equal to or above 1.0 more than the average standardized values of the several different non-responders liver tissues. The “standardized values” of the Hepatitis C liver tissues were derived by subtracting the median of the several different Hepatitis C negative liver tissue values from each probeset value, then divided by the interquantile range (IQR) of the same several Hepatitis C negative liver tissue values.

TABLE 14A
Pkey	ExAccn	UnigeneID	Unigene Title	R1	R2
413278	BE563085	Hs. 833	interferon-stimulated protein, 15 kDa	2.39E−04	8.04
402399			C19001025*: gi|11275298|dbj|BAB18302.1|(	9.60E−03	4.25
446783	AW138343	Hs. 141867	ESTs	2.95E−03	4.19
422596	AF063611	Hs. 118633	2′-5′-oligoadenylate synthetase-like	5.19E−03	4.03
433364	AI075407	Hs. 296083	ESTs, Moderately similar to I54374 gene	6.90E−03	3.97
447567	AW474513	Hs. 224397	ESTs, Weakly similar to I38931 Wiskott-A	6.87E−03	3.89
432680	T47364	Hs. 278613	interferon, alpha-inducible protein 27	4.46E−03	3.28
457974	AW842353	Hs. 321717	ESTs, Weakly similar to S22765 heterogen	9.02E−03	2.76
448436	AI520706	Hs. 171012	hypothetical protein FLJ22349	3.22E−03	2.71
405481			Target Exon	7.36E−03	2.65
415682	AI347128	Hs. 191870	ESTs	6.94E−03	2.64
444534	AW271626	Hs. 42294	ESTs	3.28E−03	2.62
417199	H48304		gb: yq77c01.r1 Soares fetal liver spleen	2.23E−03	2.50
440798	AB020648	Hs. 7426	KIAA0841 protein	1.00E−03	2.40
458492	AI143655		ESTs	8.29E−03	2.27
453989	M63962	Hs. 36992	ATPase, H? exchanging, alpha polypeptide	1.16E−03	2.25
409703	NM_006187	Hs. 56009	2′-5′-oligoadenylate synthetase 3 (100 k	5.99E−03	2.22
412003	R11775		ESTs, Weakly similar to Z195_HUMAN ZINC	7.01E−03	2.20
400423	AF264765		Target	7.03E−03	2.16
409665	NM_006731	Hs. 55777	Fukuyama type congenital muscular dystro	8.24E−03	2.12
438146	Z36842	Hs. 57548	ESTs	9.92E−03	2.10
401191			crystallin, beta A1	6.98E−03	2.06
420875	AA782222	Hs. 293224	ESTs, Weakly similar to ALU1_HUMAN ALU S	5.64E−03	2.06
423729	R01566	Hs. 5461	ESTs	1.99E−03	2.04
400301	X03635	Hs. 1657	estrogen receptor 1	2.35E−03	2.03
402885			Target Exon	4.26E−03	2.00
431620	AA126109	Hs. 264981	2′-5′-oligoadenylate synthetase 2 (69-71	4.05E−03	1.96
414915	NM_002462	Hs. 76391	myxovirus (influenza) resistance 1, homo	2.34E−03	1.94
435956	AF269255	Hs. 22604	lysosomal apyrase-like protein 1	1.31E−03	1.90
418165	R45959	Hs. 6637	ESTs	3.05E−03	1.89
449261	AI637592		ESTs	3.00E−03	1.89
458833	AW236702	Hs. 171431	ESTs, Weakly similar to A46010 X-linked	6.83E−03	1.87
433156	R59206	Hs. 17519	Homo sapiens cDNA: FLJ22539 fis, clone H	4.62E−04	1.86
405468			NM_022820*: Homo sapiens cytochrome P450	1.23E−03	1.85
420772	AW752656	Hs. 222707	KIAA1718 protein	3.77E−04	1.85
451505	AI290219	Hs. 25223	ESTs, Highly similar to YSHUT threonine-	7.46E−03	1.84
423955	AI420582	Hs. 136164	cutaneous T-cell lymphoma-associated tum	7.60E−04	1.83
433207	AB040903	Hs. 284146	hypothetical protein DKFZp762N0610	9.89E−03	1.83
402605			Target Exon	3.64E−03	1.82
427958	AA418000	Hs. 98280	potassium intermediate/small conductance	5.64E−03	1.82
416879	H98899	Hs. 42599	ESTs	8.76E−03	1.81
458891	AI659166	Hs. 207144	ESTs	8.31E−03	1.78
432384	AW006770	Hs. 162193	ESTs	4.60E−03	1.78
424049	A8014524	Hs. 138380	KIAA0624 protein	3.61E−04	1.77
415723	AA330633	Hs. 23450	mitochondrial ribosomal protein S25	2.35E−03	1.76
437556	AI223078	Hs. 136776	ESTs	4.24E−03	1.75
436869	NM_014867	Hs. 5333	KIAA0711 gene product	6.34E−03	1.75
417054	AF017060		aldehyde oxidase 1	3.52E−03	1.75
411194	AW821559		gb: IL2-ST0311-271299-030-D03 ST0311 Homo	4.86E−03	1.74
421822	AV650066	Hs. 1430	coagulation factor XI (plasma thrombopla	9.90E−04	1.71
453866	AW291498	Hs. 250557	ESTs	6.34E−03	1.70
414812	X72755	Hs. 77367	monokine induced by gamma interferon	2.10E−03	1.68
457247	AA458605		KIAA1681 protein	9.08E−03	1.66
426315	AA854219	Hs. 348137	Homo sapiens, clone IMAGE: 3542716, mRNA,	1.33E−03	1.66
449774	R06076		gb: ye94c02.s1 Soares fetal liver spleen	1.81E−03	1.66
439281	AA100768	Hs. 48485	ESTs, Weakly similar to I38022 hypotheti	9.06E−03	1.65
435545	AA687415	Hs. 28107	ESTs	5.39E−03	1.65
453336	AW139766	Hs. 233431	ESTs	5.32E−04	1.64
403640			ENSP00000233023*: CDNA FLJ12662 fis, clon	8.54E−04	1.63
436790	AI498610		ESTs	5.14E−03	1.62
400552			Target Exon	9.71E−04	1.62
427185	AA398930		ESTs	3.78E−03	1.61
403609			C3001199: gi|7494834|pir||T15308 hypothet	1.26E−03	1.60
425468	BE141170		gb: MR0-HT0077-011099-001-a05 HT0077 Homo	5.35E−03	1.59
415374	F06904	Hs. 8346	ESTs	8.79E−03	1.59
440700	AW952281	Hs. 296184	guanine nucleotide binding protein (G pr	9.04E−03	1.59
424465	AI216391	Hs. 169939	heparan sulfate 2-O-sulfotransferase	3.85E−03	1.56
430374	AF064104	Hs. 22116	CDC14 (cell division cycle 14, S. cerevi	1.66E−03	1.56
418129	X52997	Hs. 1144	glycoprotein IX (platelet)	8.20E−03	1.55
421497	BE145334		BANP homolog, SMAR1 homolog	8.31E−04	1.54
440083	AI433721	Hs. 164153	ESTs	4.34E−03	1.53
401740			ENSP00000005503*: SA (rat hypertension-as	8.69E−03	1.53
447083	AI472124	Hs. 157757	ESTs	7.48E−03	1.52
411183	BE141178		gb: MR0-HT0077-011099-002-b06 HT0077 Homo	6.03E−03	1.52
426912	AL043054	Hs. 256657	ESTs, Weakly similar to A46302 PTB-assoc	2.41E−03	1.51
405720			Target Exon	5.64E−03	1.51
442068	BE312873	Hs. 314932	ESTs	5.81E−03	1.50
400279			NM_004581*: Homo sapiens Rab geranylgeran	9.72E−03	1.49
428138	AA773842	Hs. 293799	ESTs	2.77E−03	1.49
451792	AA019795	Hs. 200235	ESTs	1.40E−03	1.49
400846			sortilin-related receptor, L(DLR class)	7.96E−04	1.48
438683	AA813982		ESTs	7.91E−03	1.48
425304	AA463844	Hs. 31339	fibroblast growth factor 11	9.32E−03	1.42
433785	BE044593	Hs. 112704	ESTs	3.60E−03	1.42
421488	F13451	Hs. 77515	gb: HSC37A091 normalized infant brain cDN	4.59E−03	1.41
443150	AI034467	Hs. 34650	ESTs	4.28E−04	1.39
401439			NM_022495*: Homo sapiens hypothetical pro	9.26E−04	1.38
429443	AB028967	Hs. 202687	potassium voltage-gated channel, Shal-re	3.53E−03	1.36
408299	AW886716	Hs. 154396	hypothetical protein FLJ22282	3.26E−03	1.35
427009	AA394290	Hs. 97353	ESTs	5.89E−03	1.34
415770	M79237		gb: EST01385 Subtracted Hippocampus, Stra	3.83E−03	1.34
431718	AI337294		GaINAc alpha-2, 6-sialyltransferase I, I	8.31E−04	1.33
443765	AI084960	Hs. 334589	ESTs	1.23E−03	1.33
436945	AA918210	Hs. 121116	ESTs	6.32E−03	1.33
429018	AW892660	Hs. 146286	kinesin family member 13A	8.65E−04	1.33
428207	BE263644	Hs. 169119	gb: 601192069F1 NIH_MGC_7 Homo sapiens cD	3.47E−03	1.30
433611	AW327692	Hs. 3446	mitogen-activated protein kinase kinase	5.80E−03	1.29
438900	AA827856	Hs. 124299	ESTs	9.32E−03	1.29
444131	AI806600	Hs. 328579	EST, Weakly similar to A55362 procollage	6.31E−03	1.28
458153	AI792267	Hs. 125363	ESTs	2.19E−03	1.28
425326	AW501870		gb: UI-HF-BR0p-ajo-g-06-0-UI.r1 NIH_MGC_5	4.51E−03	1.28
428803	AA913233	Hs. 153179	ESTs, Highly similar to Human Recombinan	7.01E−03	1.28
409570	AW418720	Hs. 167583	ESTs	7.21E−03	1.26
415835	Z45365		gb: HSC2NF061 normalized infant brain cDN	5.71E−03	1.26
403740			NM_001076*: Homo sapiens UDP glycosyltran	4.08E−03	1.24
446780	R31107		gb: yh61g01.s1 Soares placenta Nb2HP Homo	2.41E−03	1.24
443773	AV646452	Hs. 30941	calcium channel, voltage-dependent, beta	4.95E−03	1.24
409008	AA059392	Hs. 66791	ESTs	6.61E−03	1.23
426426	AI569804	Hs. 42792	ESTs, Weakly similar to I78885 serine/th	6.82E−03	1.23
436752	AW298529		ESTs	2.55E−03	1.23
455202	AW865320		gb: PM4-SN0020-300300-007-a11 SN0020 Homo	8.34E−03	1.21
445613	BE550889	Hs. 158491	ESTs	7.33E−03	1.20
442387	AI239835	Hs. 341782	ESTs	2.43E−03	1.19
444521	H58280	Hs. 8366	ESTs	4.22E−04	1.19
458273	AW770493	Hs. 182874	guanine nucleotide binding protein (G pr	9.33E−03	1.19
419662	W87674		gb: zh66a01.r1 Soares_fetal_liver_spleen—	6.47E−04	1.18
402842			ENSP00000241325*: DJ947L8.1.3 (novel CUB	7.14E−03	1.18
417715	AW969587	Hs. 86366	ESTs	9.63E−03	1.15
410209	AI583661	Hs. 60548	hypothetical protein PRO1635	3.03E−03	1.15
414832	W27128	Hs. 100057	Homo sapiens cDNA: FLJ22902 fis, clone K	1.12E−03	1.14
425851	NM_001490	Hs. 159642	glucosaminyl (N-acetyl) transferase 1, c	7.36E−03	1.14
408906	AW294539	Hs. 255323	ESTs	7.49E−03	1.13
444211	AW390415	Hs. 79013	ESTs, Moderately similar to 1207289A rev	5.07E−03	1.13
444362	AW892056	Hs. 110853	ESTs	2.18E−03	1.12
418453	T93674	Hs. 268815	ESTs	8.59E−03	1.11
427761	AA412205	Hs. 140996	ESTs	8.41E−03	1.11
402149			Target Exon	6.08E−03	1.10
412150	AW895719		gb: QV4-NN0039-290300-154-f06 NN0039 Homo	2.46E−03	1.10
446250	AI283067	Hs. 320873	EST	9.30E−03	1.10
427201	AB037860	Hs. 173933	nuclear factor I/A	2.60E−03	1.10
439620	AA838727	Hs. 124405	ESTs, Weakly similar to A46010 X-linked	6.98E−03	1.10
401929			C17001690: gi|6005701|ref|NP_009099.1|AT	8.77E−03	1.08
406466			Target Exon	4.76E−04	1.07
446266	AI417271	Hs. 163949	ESTs, Weakly similar to I38022 hypotheti	5.84E−03	1.06
424579	BE614288	Hs. 285391	DKFZP564P1916 protein	4.35E−03	1.06
453585	AL043430	Hs. 325309	hypothetical protein FLJ14596	3.07E−03	1.06
420399	AA743258	Hs. 291545	ESTs	6.92E−03	1.05
435147	AL133731	Hs. 4774	Homo sapiens mRNA; cDNA DKFZp761C1712 (f	6.17E−03	1.04
400636			C10001873: gi|11056014|ref|NP_067651.1|a	8.97E−03	1.03
436737	AI052229	Hs. 25373	ESTs, Weakly similar to T20410 hypotheti	8.30E−03	1.03
414278	AA330116		Human glucose transporter pseudogene	2.95E−03	1.02
457599	AW997833	Hs. 257267	FYVE and coiled-coil domain containing 1	5.05E−03	1.01
431006	BE152871		gb: CM1-HT0333-101299-064-d12 HT0333 Homo	5.72E−03	1.01
421932	W51778	Hs. 323949	kangai 1 (suppression of tumorigenicity	2.60E−03	1.01
405761			ENSP00000203606: CDNA FLJ14191 fis, clone	6.05E−03	1.01
450078	AI681743		gb: tx38g10.x1 NCI_CGAP_Lu24 Homo sapiens	3.38E−03	1.01
402942			Target Exon	5.84E−03	1.00
Pkey: Unique Eos probeset identifier numbe
ExAccn: Exemplar Accession number, Genbank accession number
UnigeneID: Unigene number
Unigene Title: Unigene gene title
R1: T-test p-value
R2: Difference of the average standardized value of responders vs. the average standardized value of non-responders

[0375]

TABLE 14B
Pkey	CAT Number	Accession
417199	1965264_1	AA194635 H48304 R22482 R99998
458492	2797412_1	AI869287 AI143655
412003	1146633_1	R11775 F05441 F07670 AW883427 T26374
449261	3029652_1	AI923721 AI860294 AI637592
417054	12405_2	BG533564 BG618564 AW296119 AI269233 BF508328 AW364777 AW292258
		AA371049 AI452471 AI092522 BG618376 AL049080 AA631068
		BG564643 T53833 AV702544 BG533452 AV705004 AA588281 T28665 BG569026 AV646874 AV647253
		AV647455 AV647749 BI759444
		AV652457 AV695354 AV696010 AV697248 BG617586 AV722549 AI435836 AI590676 AI245019 AW338243
		AA530898 D52191 AI435352
		D57473 BG566952 AI420505 AA035245 AV704972 BG564113 AI439237 AI287456 AV695686 AA349017
411194	1072676_1	AW821558 AW821559 AW821557 AW821643 AW821560 AW821497 AW821639
		AW821498 AW821496 AW821499
457247	22785_1	AB051468 AW977252 AI261627 AW665579 AW274550 AI418272 AW293861
		AA731376 BF798878 BF445807 AB053320 AK022729 AW959911
		AV658411 H10450 AI073358 AA889598 BF445392 AI368772 AA421057 AA702576 F09058 AA327610
		AL135425 AU135871 AU125838
		BE467087 BG661269 AI697843 BF111090 AI814556 AI689772 BE348775 AI689791 BF475299 AA987614
		AI802005 N79670 BG564339
		AW172331 AW592078 AA487432 AI270312 BF062573 AI755254 AI655337 AI753287 AI753432 N63992
		AA758915 AA903180 AA126824
		AI202889 AA778528 H99263 BF435656 BI755650 AW806648 BE547432 AA872493 H49166 AI167329
		BG222086 AW751006 AW751005
		BE827287 BI521573 BE737978 AA194149 W74616 AW138578 AI128240 AI498242 BM314911
		AA642425 AW583264 AI332987 AW241875
		N62879 AI362749 AI761951 AI370777 AI332423 AA903009 AI207967 AI435328 BG222922 BG222858
		AW262522 AA758655 AA649251
		AA235233 N77786 H30532 H30545 T94316 AW855131 AW992588 BG998544 BE076575 BG958225
		AW772819 T83121 T80942 BF088923
449774	79702_1	AA007258 R06179 AA004224 R06076
436790	647116_1	AI936636 AI498610 AI589571 AA731428 AW182143
427185	1312946_1	AI204518 AA398930 AA402069
425468	1280868_1	BE141170 BE141413 BE141342 AA357975
421497	MH1660_34	BM012343 BG990287 BI054221 AA292029 BE090740 BE147105 BF945352
		BE147159 AW837076 BE702303 BE166423 BF833717 BF898447
		BF945348 AW085137 N58701 T81141 BG977546 BE160737 R81151 BF833715 R76844 BE145334
		AA292072 BF747231
411183	1072365_1	BE141178 AW821110 BI048110
400279	2140_1	Y08200 NM_004581 BC003093 BE733834 BI753321 BG773890 BF091906
		BI917541 AI023762 AA587230 BF435086 AI264262 AI687392
		AI810536 AW589886 AI244419 AA749261 AA535435 AW205689 AI765770 AI765431 C02465 AW305347
		AI818456 AA322111 AW381845
		AW381829 AV749407 AA811636 AU159893 AA603065 AA652542 AI468678 R49616 AW381863 BE389867
		BE182387 BF087771 AA527551
		AA134051 AA831504 AA134052 AI871759 AW089048 BI913532 AA367709 BG828155 BF093014
438683	1241644_1	AA813982 AW978060 AA825734
415770	2051914_1	AA169260 AI267298 M79237
431718	3517_3	AW970730 AA524205 AW293340 AI337294 AA514491 AI858216 AA552097 AI857575
425326	916327_1	BE886799 AW846391 AW501870 AW502583 AW503003 AA355226 AW751981
		AW846539 R11565 AA378251 AW846548 AW846136
		AW846484
415835	1894612_1	T77496 Z45365 H05203 R25905
446780	1290689_1	AL568290 AI653198 AA371134 BE005364 AI341136 BI493548 H04953 R31107
436752	727461_1	AW977246 AW298529 AA972071 AA730213
455202	1108949_1	AW865320 AW865316 AW865249 AW865381 AW865379 BF373916 AW865250
		AW865118 AW865123 AW865391 AW865043 BF373931
		BF373934 AW865448
419662	2431548_1	W87872 W87674 W87774
412150	1155126_1	AW895719 N31451 N41451
414278	2649_1	BG564077 AA928199 BI491412 AI913576 AI769974 AA805536 AI978876 AI879646
		AI640283 BM153392 AA137260 AI151263 AI474103
		AW078667 AW079202 AA150376 BE048238 AI218961 AA631892 AI350813 AI758351 AI458422 AA150275
		AI038862 AW183342 AA912346
		AW468933 AI003046 AI208534 H60032 T34660 Z40410 AA621093 BE245388 N66384 AW118966 T17277
		AW020353 BE467084 AI268780
		BE003683 AA330116 R77760 AI473113 AI985726 BE813657 BE813503 BF326782 AI690850 N52225
		AW994769 BI036529 R40472 BE813513
431006	1524128_1	AA490552 BE152870 BE152871
450078	1156200_1	AI681743 AW897284 AW897205 AW897287
Pkey: Unique Eos probeset identifier number
CAT number: Gene cluster number
Accession: Genbank accession numbers

[0376]

TABLE 14C
Pkey	Ref	Strand	Nt_position
402399	1905915	Minus	24502-24666, 24986-25102
405481	3688109	Plus	5718-5837, 8719-8818
401191	9716907	Plus	22341-22636
402885	9926751	Plus	71919-72049
405468	8051573	Minus	69367-69529, 71227-71453,
			73076-73236
402605	9909420	Minus	47680-47973
403640	8671948	Minus	161756-161859, 164798-164914
400552	9801071	Plus	93101-93276
403609	8308266	Minus	125974-126320
401740	2982169	Plus	148357-148484, 148591-148690
405720	9797144	Plus	13409-13861
400846	9188605	Plus	39310-39474
401439	8246737	Plus	92993-94026
403740	7630882	Plus	86504-87227
402842	9369121	Minus	76355-76479
402149	8079589	Minus	86399-86618
401929	3810670	Minus	3167-3286, 4216-4310
406466	9795550	Plus	115511-115658, 118766-118915,
			121699-12177
400636	3818355	Minus	102143-102322
405761	1332524	Minus	22866-23294
402942	9368398	Plus	102152-102386
Pkey: Unique number corresponding to an Eos probeset
Ref: Sequence source. The 7 digit numbers in this column are Genbank Identifier (GI) numbers. “Dunham, et al.” refers to the publication entitled “The DNA sequence of human chromosome 22” Dunham, et al. (1999) Nature 402: 489-495.
Strand: Indicates DNA strand from which exons were predicted.
Nt_position: Indicates nucleotide positions of predicted exons.

[0377]

TABLE 15
Pkey: 444342
UnigeneID: Hs.10887
Unigene Title: similar to lysosome-associated membrane glycoprotein
DNA Sequence
Nucleic Acid Accession #: NM_014398.1
Coding sequence: 64..1314
1          11         21         31         41         51
|          |          |          |          |          |
GGCACCGATT CGGGGCCTGC CCGGACTTCG CCGCACGCTG CAGAACCTCG CCCAGCGCCC 60
ACCATGCCCC GGCAGCTCAG CGCGGCGGCC GCGCTCTTCG CGTCCCTGGC CGTAATTTTG 120
CACGATGGCA GTCAAATGAG AGCAAAAGCA TTTCCAGAAA CCAGAGATTA TTCTCAACCT 180
ACTGCAGCAG CAACAGTACA GGACATAAAA AAACCTGTCC AGCAACCAGC TAAGCAAGCA 240
CCTCACCAAA CTTTAGCAGC AAGATTCATG GATGGTCATA TCACCTTTCA AACAGCGGCC 300
ACAGTAAAAA TTCCAACAAC TACCCCAGCA ACTACAAAAA ACACTGCAAC CACCAGCCCA 360
ATTACCTACA CCCTGGTCAC AACCCAGGCC ACACCCAACA ACTCACACAC AGCTCCTCCA 420
GTTACTGAAG TTACAGTCGG CCCTAGCTTA GCCCCTTATT CACTGCCACC CACCATCACC 480
CCACCAGCTC ATACAGCTGG AACCAGTTCA TCAACCGTCA GCCACACAAC TGGGAACACC 540
ACTCAACCCA GTAACCAGAC CACCCTTCCA GCAACTTTAT CGATAGCACT GCACAAAAGC 600
ACAACCGGTC AGAAGCCTGA TCAACCCACC CATGCCCCAG GAACAACGGC AGCTGCCCAC 660
AATACCACCC GCACAGCTGC ACCTGCCTCC ACGGTTCCTG GGCCCACCCT TGCACCTCAG 720
CCATCGTCAG TCAAGACTGG AATTTATCAG GTTCTAAACG GAAGCAGACT CTGTATAAAA 780
GCAGAGATGG GGATACAGCT GATTGTTCAA GACAAGGAGT CGGTTTTTTC ACCTCGGAGA 840
TACTTCAACA TCGACCCCAA CGCAACGCAA GCCTCTGGGA ACTGTGGCAC CCGAAAATCC 900
AACCTTCTGT TGAATTTTCA GGGCGGATTT GTGAATCTCA CATTTACCAA GGATGAAGAA 960
TCATATTATA TCAGTGAAGT GGGAGCCTAT TTGACCGTCT CAGATCCAGA GACAGTTTAC 1020
CAAGGAATCA AACATGCGGT GGTGATGTTC CAGACAGCAG TCGGGCATTC CTTCAAGTGC 1080
GTGAGTGAAC AGAGCCTCCA GTTGTCAGCC CACCTGCAGG TGAAAACAAC CGATGTCCAA 1140
CTTCAAGCCT TTGATTTTGA AGATGACCAC TTTGGAAATG TGGATGAGTG CTCGTCTGAC 1200
TACACAATTG TGCTTCCTGT GATTGGGGCC ATCGTGGTTG GTCTCTGCCT TATGGGTATG 1260
GGTGTCTATA AAATCCGCCT AAGGTGTCAA TCATCTGGAT ACCAGAGAAT CTAATTGTTG 1320
CCCGGGGGGA ATGAAAATAA TGGAATTTAG AGAACTCTTT CATCCCTTCC AGGATGGATG 1380
TTGGGAAATT CCCTCAGAGT GTGGGTCCTT CAAACAATGT AAACCACCAT CTTCTATTCA 1440
AATGAAGTGA GTCATGTGTG ATTTAAGTTC AGGCAGCACA TCAATTTCTA AATACTTTTT 1500
GTTTATTTTA TGAAAGATAT AGTGAGCTGT TTATTTTCTA GTTTCCTTTA GAATATTTTA 1560
GCCACTCAAA GTCAACATTT GAGATATGTT GAATTAACAT AATATATGTA AAGTAGAATA 1620
AGCCTTCAAA TTATAAACCA AGGGTCAATT GTAACTAATA CTACTGTGTG TGCATTGAAG 1680
ATTTTATTTT ACCCTTGATC TTAACAAAGC CTTTGCTTTG TTATCAAATG GACTTTCAGT 1740
GCTTTTACTA TCTGTGTTTT ATGGTTTCAT GTAACATACA TATTCCTGGT GTAGCACTTA 1800
ACTCCTTTTC CACTTTAAAT TTGTTTTTGT TTTTTGAGAC GGAGTTTCAC TCTTGTCACC 1860
CAGGCTGGAG TACAGTGGCA CGATCTCGGC TTATGGCAAC CTCCGCCTCC CGGGTTCAAG 1920
TGATTCTCCT GCTTCAGCTT CCCGAGTAGC TGGGATTACA GGCACACACT ACCACGCCTG 1980
GCTAATTTTT GTATTTTTAT TATAGACGGG TTTCACCATG TTGGCCAGAC TGGTCTTGAA 2040
CTCTTGACCT CAGGTGATCC ACCCACCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG 2100
AGCCATTGCG CCCGGCCTTA AATGTTTTTT TTAATCATCA AAAAGAACAA CATATCTCAG 2160
GTTGTCTAAG TGTTTTTATG TAAAACCAAC AAAAAGAACA AATCAGCTTA TATTTTTTAT 2220
CTTGATGACT CCTGCTCCAG AATTGCTAGA CTAAGAATTA GGTGGCTACA GATGGTAGAA 2280
CTAAACAATA AGCAAGAGAC AATAATAATG GCCCTTAATT ATTAACAAAG TGCCAGAGTC 2340
TAGGCTAAGC ACTTTATCTA TATCTCATTT CATTCTCACA ACTTATAAGT GAATGAGTAA 2400
ACTGAGACTT AAGGGAACTG AATCACTTAA ATGTCACCTG GCTAACTGAT GGCAGAGCCA 2460
GAGCTTGAAT TCATGTTGGT CTGACATCAA GGTCTTTGGT CTTCTCCCTA CACCAAGTTA 2520
CCTACAAGAA CAATGACACC ACACTCTGCC TGAAGGCTCA CACCTCATAC CAGCATACGC 2580
TCACCTTACA GGGAAATGGG TTTATCCAGG ATCATGAGAC ATTAGGGTAG ATGAAAGGAG 2640
AGCTTTGCAG ATAACAAAAT AGCCTATCCT TAATAAATCC TCCACTCTCT GGAAGGAGAC 2700
TGAGGGGCTT TGTAAAACAT TAGTCAGTTG CTCATTTTTA TGGGATTGCT TAGCTGGGCT 2760
GTAAAGATGA AGGCATCAAA TAAACTCAAA GTATTTTTAA ATTTTTTTGA TAATAGAGAA 2820
ACTTCGCTAA CCAACTGTTC TTTCTTGAGT GTATAGCCCC ATCTTGTGGT AACTTGCTGC 2880
TTCTGCACTT CATATCCATA TTTCCTATTG TTCACTTTAT TCTGTAGAGC AGCCTGCCAA 2940
GAATTTTATT TCTGCTGTTT TTTTTGCTGC TAAAGAAAGG AACTAAGTCA GGATGTTAAC 3000
AGAAAAGTCC ACATAACCCT AGAATTCTTA GTCAAGGAAT AATTCAAGTC AGCCTAGAGA 3060
CCATGTTGAC TTTCCTCATG TGTTTCCTTA TGACTCAGTA AGTTGGCAAG GTCCTGACTT 3120
TAGTCTTAAT AAAACATTGA ATTGTAGTAA AGGTTTTTGC AATAAAAACT TACTTTGG 3178
Protein Sequence
Protein Accession #: NP_055213.1
1          11         21         31         41         51
|          |          |          |          |          |
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP 60
HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV 120
TEVTVGPSLA PYSLPPTITP PAHTAGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST 180
TGQKPDQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA 240
EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 300
YYISEVGAYL TVSDPETVYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL 360
QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI 416

[0378] It is understood that the examples described above in no way serve to limit the true scope of this invention, but rather are presented for illustrative purposes. All publications, sequences of accession numbers, and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.

Claims

1. A method of detecting an RNA transcript associated with Hepatitis C infection in a cell from a patient, the method comprising contacting a biological sample from the patient with a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15.

2. The method of claim 1, wherein: a) the biological sample comprises isolated nucleic acids; or b) the marker expression provides prognostic information to determine treatment alternative.

3. The method of claim 2, wherein the nucleic acids are mRNA.

4. The method of claim 2, further comprising the step of amplifying nucleic acids before the step of contacting the biological sample with the polynucleotide.

5. The method of claim 1, wherein the polynucleotide comprises a sequence as shown in Tables 1A-15.

6. The method of claim 1, wherein the polynucleotide is immobilized on a solid surface.

7. The method of claim 1, wherein the patient is undergoing a therapeutic regimen to treat Hepatitis C infection and/or its secondary consequences.

8. The method of claim 1, wherein the patient is suspected of suffering from Hepatitis C infection.

9. An isolated nucleic acid molecule consisting of a polynucleotide sequence as shown in Tables 1A-15.

10. The nucleic acid molecule of claim 9, which is labeled.

11. An expression vector comprising the nucleic acid of claim 9.

12. A host cell comprising the expression vector of claim 11.

13. An isolated polypeptide which is encoded by a nucleic acid molecule having polynucleotide sequence as shown in Tables 1A-15.

14. An antibody that specifically binds a polypeptide of claim 13.

15. The antibody of claim 14, further conjugated to an effector component.

16. The antibody of claim 15, wherein the effector component is a fluorescent label.

17. The antibody of claim 15, wherein the effector component is a radioisotope or a cytotoxic chemical.

18. The antibody of claim 15, which is an antibody fragment.

19. The antibody of claim 15, which is a humanized antibody

20. A method of detecting a cell affected by Hepatitis C infection or its secondary consequences in a biological sample from a patient, the method comprising contacting the biological sample with an antibody of claim 14.

21. The method of claim 20, wherein the antibody is further conjugated to an effector component.

22. The method of claim 21, wherein the effector component is a fluorescent label.

23. A method for identifying a compound that modulates a Hepatitis C infection-associated polypeptide, the method comprising the steps of: a) contacting the compound with a Hepatitis C infection-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15 and b) determining the functional effect of the compound upon the polypeptide.

24. A drug screening assay comprising the steps of a) administering a test compound to a mammal suffering from Hepatitis C infection and its secondary consequences or a cell isolated therefrom b) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as shown in Tables 1A-15 in a treated cell or mammal with the level of gene expression of the polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of Hepatitis C infection and its secondary consequences.