Claims
- 1. An array comprising at least 10 distinct nucleic acid probes, each probe being comprised of 9 or more consecutive nucleotides from at least one of the sequences listed in SEQ ID NOS: 1-14396, or the perfect sense match, sense mismatch, antisense match or antisense mismatch thereof.
- 2. The array of claim 1 comprising a plurality of nucleic acid probes, wherein each probe comprises one of the sequences listed in SEQ ID NOS: 1-14396 or the perfect sense match, sense mismatch, antisense match or antisense mismatch thereof.
- 3. The array of claim 1 wherein said array is used to monitor gene expression levels by hybridization to a DNA library.
- 4. The array of claim 1 wherein said array is used for analysis of genetic variation.
- 5. The array of claim 1 wherein said array is used for hybridization of tag-labeled compounds.
- 6. A method of analysis comprising:
a) hybridizing one or more nucleic acids to two or more nucleic acid probes, each probe comprising at least one of the sequences listed in SEQ ID NOS: 1-14396, or the perfect sense match, sense mismatch, antisense match or antisense mismatch thereof; and b) detecting said hybridization.
- 7. The method of claim 6 wherein said nucleic acid probes are attached to a solid support.
- 8. The method of claim 6 wherein said analysis comprises monitoring gene expression levels.
- 9. The method of claim 8 wherein said monitoring gene expression levels comprises comparing gene expression levels of nucleic acids derived from two or more different samples and further comprises the step of: comparing said hybridization patterns between said nucleic acids derived from said two or more different samples.
- 10. The method of claim 6 wherein said method of analysis comprises identifying biallelic markers.
- 11. The method of claim 6 wherein said method of analysis comprises identifying polymorphisms.
- 12. The method of claim 6 wherein said method of analysis comprises a crossspecies comparison wherein the hybridization patterns of a pool of nucleic acids derived from one species are compared with the hybridization patterns of a pool of nucleic acids derived from another species.
- 13. The method of claim 6 wherein each of said nucleic acids further comprise a tag sequence.
- 14. The method of claim 6 wherein said method of analysis is a method of identifying family members of a gene.
- 15. A method comprising using any one or more nucleic acid sequences comprising at least one of the sequences listed in SEQ ID NOS: 1-14396, or the perfect sense match, sense mismatch, antisense match or antisense mismatch thereof as a probe.
- 16. The method of claim 15 wherein said probe is used in an in situ hybridization.
- 17. The method of claim 15 wherein said probe is used to screen cDNA or genomic libraries, or subclones derived from them, for additional clones containing segments of DNA that have been isolated and previously sequenced.
- 18. The method of claim 15 wherein said probe is used in Southern, northern, or dot-blot hybridization to identify or detect the sequence of any gene.
- 19. The method of claim 15 wherein said probe is used in Southern or dot-blot hybridization of genomic DNA to detect specific mutations in any gene.
- 20. The method of claim 15 wherein said probe is used to map the 5′ termini of mRNA molecules by primer extensions.
RELATED APPLICATIONS
[0001] This application claims priority to Provisional Application Serial No. 60/311,040 filed Aug. 8, 2001, which is herein incorporated by reference in its entirety for all purposes.
Provisional Applications (1)
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Number |
Date |
Country |
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60311040 |
Aug 2001 |
US |