Claims
- 1. A method of inhibiting the division of a cell which comprises contacting the cell with a composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein:X is selected from the group: O, S, and NR; R is selected from the group: H, C1-4 alkyl, and NR5R5a; R1 is selected from the group: H, C1-10 alkyl substituted with 0-3 RC, C2-10 alkenyl substituted with 0-3 Rc, C2-10 alkynyl substituted with 0-3 Rc, —NHR4, C3-10 carbocycle substtuted with 0-5 Ra, and 3-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S and substituted with 0-5 Rb; Ra is independently at each occurrence selected from the group: halo, —CN, N3, NO2, C1-4 alkyl, C1-4 haloalkyl, NR3R3a, ═O, OR3, COR3, CO2R3, CONR3R3a, NHC(O)NR3R3a, NHC(S)NR3R3a, NR3C(O)OR3, NR3C(O)R3, SO2NR3R3a, SO2R3b, and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S; alternatively, when two Ra's are present on adjacent carbon atoms they combine to form —OCH2O— or —OCH2CH2O—; Rb is independently at each occurrence selected from the group: halo, —CN, NO2, C1-4 alkyl, C1-4 haloalkyl, NR3R3a, NR3C(O)OR3, NR3C(O)R3, OR3, COR3, CO2R3, CONR3R3a, NHC(O)NR3R3a, NHC(S)NR3R3a, SO2NR3R3a, and SO2R3b; Rc is independently at each occurrence selected from the group: halo, —CN, NO2, C1-4 alkyl, C1-4 haloalkyl, NR3R3a, NR5NR5R5a, NR3C(O)OR3, NR3C(O)R3,═O, OR3, COR3, CO2R3, CONR3R3a, NHC(O)NR3R3a, NHC(S)NR3R3a, SO2N3R3a, SO2R3b, C3-10 carbocycle substituted with 0-5 Ra, and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R3; R2 is selected from the group: H, C1-10 alkyl substituted with 0-3 Rc, C2-10 alkenyl substituted with 0-3 Rc, C2-10 alkynyl substituted with 0-3 Rc, —(CF2)mCF3, C3-10 carbocycle substituted with 0-5 Ra, and 3-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S and substituted with 0-5 Rb; R3 is selected from the group: H, halo, —CN, N3, NO2, C1-4 haloalkyl, NR5R5a, NR5NR5R5a, NR5C(O)OR5, NR5C(O)R5,═O, OR5, COR5, CO2R5, CONR5R5a, NHC(O)NR5R5a, NHC(S)NR5R5a, SO2NR5R5a, SO2R5b, C1 alkyl, phenyl, and benzyl; R3a is selected from the group: H, C1-4 alkyl, phenyl, and benzyl; alternatively, R3 and R3a, together with the nitrogen atom to which they are attached, form a heterocycle having 4-8 atoms in the ring and containing an additional 0-1 N, S, or O atom; R3b is selected from the group: H, C1-4 alkyl, phenyl, and benzyl; R4 is independently at each occurrence selected from the group: H, —CN, C1-4 alkyl, C1-4 haloalkyl, NR3R3a, NR3C(O)OR3, NR3C(O)R3, OR3, COR3, CO2R3, CONR3R3a, NHC(O)NR3R3a, NHC(S)NR3R3a, SO2NR3R3a, SO2R3b, C3-10 carbocycle substituted with 0-5 Ra, and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R3; R5 is independently selected from the group: H, C1-4 alkyl, phenyl and benzyl; R5a is independently selected from the group: H, C1-4 alkyl, phenyl and benzyl; R5b is independently selected from the group: H, C1-4 alkyl, phenyl and benzyl; and m is selected from 0, 1, 2, and 3., provided that R2 my not be an unsubstituted branched alkyl group when R1 is CH3.
Parent Case Info
This application is a continuation of U.S. Ser. No. 09/295,078, filed Apr. 20, 1999 now abandoned which claims benefit 60/082,476 filed Apr. 21, 1998.
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Provisional Applications (1)
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Number |
Date |
Country |
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60/082476 |
Apr 1998 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09/295078 |
Apr 1999 |
US |
Child |
09/639618 |
|
US |