METHODS OF INHIBITING PRMT5

Abstract

Described herein are compounds of Formula (I) useful for inhibiting PRMT5 activity. The planes of Ring AA and Ring BB are between 75° and 105°. Ring AA-M-Ring BB (I)

Description

BACKGROUND OF THE INVENTION

Epigenetic regulation of gene expression is an important biological determinant of protein production and cellular differentiation and plays a significant pathogenic role in a number of human diseases.

Epigenetic regulation involves heritable modification of genetic material without changing its nucleotide sequence. Typically, epigenetic regulation is mediated by selective and reversible modification (e.g., methylation) of DNA and proteins (e.g., histones) that control the conformational transition between transcriptionally active and inactive states of chromatin. These covalent modifications can be controlled by enzymes such as methyltransferases (e.g., PRMT5), many of which are associated with specific genetic alterations that can cause human disease.

Disease-associated chromatin-modifying enzymes (e.g., PRMT5) play a role in diseases such as proliferative disorders, metabolic disorders, and blood disorders. Thus, there is a need for the development of small molecules that are capable of modulating the activity of PRMT5.

BRIEF DESCRIPTION OF THE FIGURES

The drawings are exemplary and not required for enablement of the invention.

FIG. 1 shows examples of PRMT5-MEP50-compound crystals.

FIG. 2 depicts a stick-and-ribbon representation of the active site of PRMT5-Compound-FIG. 2.

FIG. 3 depicts a stick-and-ribbon representation of the active site of PRMT5-Compound A6.

FIG. 4 depicts a stick-and-ribbon representation of the active site of PRMT5-Compound-FIG. 4.

FIG. 5 depicts a stick-and-ribbon representation of the active site of PRMT5-Compound-FIG. 5.

FIG. 6 depicts a stick-and-ribbon representation of the active site of PRMT5-Compound-FIG. 6.

DESCRIPTION

PRMT5 is an attractive target for modulation given its role in the regulation of diverse biological processes. It has now been found that compounds described herein, and pharmaceutically acceptable salts and compositions thereof, are effective as inhibitors of PRMT5 Inhibitors of PRMT5 may be useful in the treatment of a wide variety of diseases including proliferative disease (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases (e.g., diabetes, obesity), and hematological diseases (e.g., hemoglobinopathies such as sickle cell disease).

In one aspect, the compounds described herein have Formula (I):

Ring AA-M-Ring BB  I

wherein Ring AA, M and Ring BB are as defined herein. In certain embodiments, Ring AA is an optionally substituted aryl moiety; Ring BB is an optionally substituted aryl or heteroaryl moiety; M is an acyclic linker moiety 3-10 atoms in length; the planes of Ring AA and Ring BB to be between 75° and 105° relative to each other. In certain embodiments, the compounds of Formula (I) inhibit PRMT5 with an IC₅₀ less than 100 nM.

In another aspect, such compounds have Formula (II):

wherein Ar′, Q, Rx, Ry, Rz are as defined herein.

In another aspect, the disclosure provides compounds that inhibit PRMT5. The disclosure provides the structural parameters of a class of compounds that inhibit PRMT5. The disclosure provides compounds with structural elements for binding in the active site of PRMT5, thereby inhibiting the function (e.g., enzymatic activity) of PRMT5. The disclosure also provides structural elements of a compound that interact with S-adenosyl methionine (SAM) in the active site of PRMT5, thereby inhibiting the function of PRMT5. For example, in certain embodiments, the compounds disclosed herein possess an aryl moiety that interacts with SAM through a pi-cation interaction. In some embodiments, the compounds disclosed herein possess an aryl moiety that interacts with Phe327 of PRMT5 through a pi-stacking interaction.

In another aspect, the disclosure provides methods for designing and/or identifying compounds that bind PRMT5 comprising generating, on a computer, a three-dimensional structure of PRMT5 having the structural coordinates of Table A, followed by identifying amino acid residues forming the active site. The identified amino acids can be used to generate a three-dimensional model of the active site for further designing and/or selecting a compound that potentially binds to the active site. In certain embodiments, the active site of PRMT5 is modeled using S-adenosyl methionine (SAM), or an analog thereof, and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580.

In another aspect, the disclosure provides methods for designing and identifying compounds that bind protein arginine N-methyltransferase 5 (PRMT5) comprising the steps of: (a) generating, on a computer, a three-dimensional structure of methyltransferase PRMT5 having the structural coordinates of Table A; (b) identifying amino acid residues forming the active site of PRMT5 in three-dimensions from step (a), wherein the active site comprises S-adenosyl methionine (SAM), or an analog thereof, and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according to Table A; (c) generating a three-dimensional model of the active site; (d) designing and/or selecting a compound that potentially binds to the active site using the three-dimensional model of the active site; and (e) optionally, synthesizing and/or choosing the potential binding compound.

In another aspect, the disclosure provides methods of identifying a compound that binds protein arginine N-methyltransferase 5 (PRMT5), the method comprising computationally identifying a compound that binds to PRMT5 using the atomic coordinates of S-adenosyl methionine (SAM), or an analog thereof, and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according the atomic coordinates provided in Table A.

In another aspect, the disclosure provides methods of identifying a compound that binds protein arginine N-methyltransferase 5 (PRMT5), the method comprising computationally identifying a binding compound that binds to PRMT5 using the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580, according to Table A.

In another aspect, the disclosure provides a method of identifying a binding compound of protein arginine N-methyltransferase 5 (PRMT5), the method comprising: computationally identifying a binding compound that binds to PRMT5 using the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581, according to the atomic coordinates provided in Table A.

In one aspect, the disclosure provides compounds that inhibit PRMT5. In one aspect, the disclosure describes structural elements useful for a compound to bind in the active site of PRMT5. In one aspect, the disclosure provides what structural elements are needed for a compound of the formula Ring AA-M-Ring BB to act as an inhibitor of PRMT5. It was surprisingly found that compounds of the formula Ring AA-M-Ring BB, wherein M is a linker that allows for the planes of Ring AA and Ring BB to be at about 90° relative to each other, inhibit the enzymatic activity of PRMT5. Compounds of the formula Ring AA-M-Ring BB with the recited geometry fit into the PRMT5 active site, thereby inhibiting the enzymatic activity of PRMT5. In some embodiments, compounds of the formula Ring AA-M-Ring BB, ring BB can form a pi-cation interaction with one more amino acids in the active site. In some embodiments, compounds of the formula Ring AA-M-Ring BB, ring BB can form a pi-stacking interaction with one more amino acids in the active site. In some embodiments, compounds of the formula Ring AA-M-Ring BB with the recited geometry fit in the active site because they are capable of a pi-cation interaction with the PRMT5-bound S-adenosyl methionine (SAM) of the active site. In some embodiments, compounds of the formula Ring AA-M-Ring BB with the recited geometry fit in the active site because they are capable of undergoing a pi-stacking interaction with Phe327. In some embodiments, compounds of the formula Ring AA-M-Ring BB with the recited geometry fit in the active site because the flexibility of the linker allows Ring BB to interact with SAM and Phe327, while at the same time allowing Ring AA to interact with Ring BB.

In one aspect, the active site of PRMT5 comprises amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In certain embodiments, the active site of PRMT5 comprises S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In some embodiments, the active site of PRMT5 comprises S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580. In some embodiments, the active site of PRMT5 comprises S-adenosyl methionine (SAM) and amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581. In some embodiments, the atomic coordinates of the active site are provided in Table A. It should be appreciated that the active site may contain a SAM analog (e.g., sinefungin) instead of SAM.

In another aspect, the disclosure provides PRMT5 inhibitors having molecular dimensions compatible with the shape of the PRMT5-active site as defined by the atomic coordinates of amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580 and, optionally, further including s-adenosyl methionine (SAM), according to Table A, wherein the compound has an IC₅₀ for PRMT5 of less than 100 nM.

In another aspect, the disclosure provides compositions comprising PRMT5 and a compound of the formula Ring AA-M-Ring BB. In some embodiments, the composition is an isolated composition comprising PRMT5 and a compound of the formula Ring AA-M-Ring BB. In some embodiments, the composition is a co-crystal comprising PRMT5 and a compound of the formula Ring AA-M-Ring BB.

In another aspect, the disclosure provides a computer readable medium comprising the atomic coordinates of the complex of PRMT5, and Compound A6 as set forth in Table A1

In another aspect, the disclosure provides a crystal structure of the complex PRMT5-Compound A6.

In another aspect, the disclosure provides kits comprising any of the disclosed compounds, or a pharmaceutically acceptable salt thereof, or pharmaceutical compositions thereof, and instructions for use.

In another aspect, the disclosure provides methods of inhibiting PRMT5 comprising contacting a cell with an effective amount of a compound, or a pharmaceutically acceptable salt thereof, or composition thereof.

In another aspect, the disclosure provides methods of altering gene expression comprising contacting a cell with an effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, or a composition thereof.

In another aspect, the disclosure provides methods of altering transcription in a call comprising contacting a cell with an effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, or a composition thereof.

In another aspect, the disclosure provides methods of treating a PRMT5-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof.

In certain embodiments, compounds described herein inhibit activity of PRMT5 by interacting with the S-adenosyl methionine (SAM) in the active site of PRMT5. In some embodiments the compounds described herein are designed in silico. In some embodiments the compounds are designed based on the crystal structure coordinates provides herein (See e.g., Table A)

In certain embodiments, compounds described herein inhibit activity of PRMT5. In certain embodiments, methods of inhibiting PRMT5 are provided which comprise contacting PRMT5 with an effective amount of a compound of Formula (I) or (II), or a pharmaceutically acceptable salt thereof. The PRMT5 may be purified or crude, and may be present in a cell, tissue, or a subject. Thus, such methods encompass inhibition of PRMT5 activity in vitro and in vivo. In certain embodiments, the PRMT5 is wild-type PRMT5. In certain embodiments, the PRMT5 is overexpressed. In certain embodiments, the PRMT5 is a mutant. In certain embodiments, the PRMT5 is in a cell. In certain embodiments, the PRMT5 is in an animal, e.g., a human. In some embodiments, the PRMT5 is in a subject that is susceptible to normal levels of PRMT5 activity due to one or more mutations associated with a PRMT5 substrate. In some embodiments, the PRMT5 is in a subject known or identified as having abnormal PRMT5 activity (e.g., overexpression). In some embodiments, a provided compound is selective for PRMT5 over other methyltransferases. In certain embodiments, a provided compound is at least about 10-fold selective, at least about 20-fold selective, at least about 30-fold selective, at least about 40-fold selective, at least about 50-fold selective, at least about 60-fold selective, at least about 70-fold selective, at least about 80-fold selective, at least about 90-fold selective, or at least about 100-fold selective relative to one or more other methyltransferases.

In certain embodiments, methods of altering gene expression in a cell are provided which comprise contacting a cell with an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, or a composition thereof. In certain embodiments, the cell is cultured in vitro. In certain embodiments, the cell is in an animal, e.g., a human.

In certain embodiments, methods of altering transcription in a cell are provided which comprise contacting a cell with an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, or a composition thereof. In certain embodiments, the cell in culture in vitro. In certain embodiments, the cell is in an animal, e.g., a human.

In some embodiments, methods of treating a PRMT5-mediated disorder are provided which comprise administering to a subject suffering from a PRMT5-mediated disorder an effective amount of a compound described herein (e.g., a compound of Formula (I)), or a pharmaceutically acceptable salt thereof. In certain embodiments, the PRMT5-mediated disorder is a proliferative disorder, a metabolic disorder, or a blood disorder. In certain embodiments, compounds described herein are useful for treating cancer. In certain embodiments, compounds described herein are useful for treating hematopoietic cancers, lung cancer, prostate cancer, melanoma, or pancreatic cancer. In certain embodiments, compounds described herein are useful for treating a hemoglobinopathy. In certain embodiments, compounds described herein are useful for treating sickle cell anemia. In certain embodiments, compounds described herein are useful for treating diabetes or obesity.

Compounds described herein are also useful for the study of PRMT5 in biological and pathological phenomena, the study of intracellular signal transduction pathways mediated by PRMT5, and the comparative evaluation of new PRMT5 inhibitors.

This application refers to various issued patent, published patent applications, journal articles, and other publications, all of which are incorporated herein by reference.

Definitions of specific functional groups and chemical terms are described in more detail below. The chemical elements are identified in accordance with the Periodic Table of h Ed., the Elements, CAS version, Handbook of Chemistry and Physics, 75^th Ed., inside cover, and specific functional groups are generally defined as described therein. Additionally, general principles of organic chemistry, as well as specific functional moieties and reactivity, are described in Thomas Sorrell, Organic Chemistry, University Science Books, Sausalito, 1999; Smith and March, March's Advanced Organic Chemistry, 5^th Edition, John Wiley & Sons, Inc., New York, 2001; Larock, Comprehensive Organic Transformations, VCH Publishers, Inc., New York, 1989; and Carruthers, Some Modern Methods of Organic Synthesis, 3^rd Edition, Cambridge University Press, Cambridge, 1987.

The “active site” of an enzyme refers to the catalytic site of the enzyme (i.e., where the reaction catalyzed by the enzyme occurs). For example, in a methyltransferase such as PRMT5, the active site is where the transfer of the methyl group from SAM is transferred to the arginine of a histone protein occurs. The structure and chemical properties of the active site typically allow the recognition and binding of a substrate. The active site typically includes residues responsible for the binding specificity (e.g., charge, hydrophobicity, and/or steric hindrance) and catalytic residues of the enzyme.

In one aspect, the active site of PRMT5 comprises amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In some embodiments, the active site of PRMT5 comprises amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580. In some embodiments, the active site of PRMT5 comprises amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581. In some embodiments, the active site of PRMT5 comprises amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Phe577, Ser578, Trp579, and Phe580. In some embodiments, the active site of PRMT5 comprises amino acids Phe300, Tyr304, Gln309, Ser310, Pro311, Leu312, Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580. In some embodiments, the active site of PRMT5 comprises amino acids Phe300, Leu312, Leu319, Gln322, Thr323, Tyr324, Val326, Phe327, Glu328, Lys333, Tyr33, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Phe577, Ser578, Trp579, Phe580, and Pro581. In some embodiments, the active site of PRMT5 comprises amino acids Phe300, Tyr304, Gln309, Ser310, Pro311, Leu312, Leu319, Thr323, Tyr324, Val326, Phe327, Glu328, Lys333, Tyr33, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Phe577, Ser578, Trp579, and Phe580. It should further be appreciated that one or more cofactors may also be present in the active site. In some embodiments, the cofactor is S-adenosyl methionine (SAM), or an analog thereof.

Amino acid residues in proteins or peptides are abbreviated as follows: phenylalanine is Phe or F; leucine is Leu or L; isoleucine is Ile or I; methionine is Met or M; valine is Val or V; serine is Ser or S; proline is Pro or P; threonine is Thr or T; alanine is Ala or A; tyrosine is Tyr or Y; histidine is His or H; glutamine is Gln or Q; asparagine is Asn or N; lysine is Lys or K; aspartic acid is Asp or D; glutamic Acid is Glu or E; cysteine is Cys or C; tryptophan is Trp or W; arginine is Arg or R; and glycine is Gly or G. For further description of amino acids, see Proteins: Structure and Molecular Properties by Creighton T. E. (1983), W. H. Freeman & Co., New York, incorporated herein by reference.

The term “atomic coordinates” refers to mathematical coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of x-rays by the atoms (scattering centers) of a protein molecule in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density map is then used to establish the positions of the individual atoms within the unit cell of the crystal. The coordinates can also be obtained by the aid of computational analysis.

As used herein, a “binding compound” refers to a compound that reversibly or irreversibly binds to PRMT5. In certain embodiments, the binding compound binds in the active site of PRMT5. A binding compound may be an inhibitor of PRMT5 (e.g., eliciting inhibition or reduction in enzymatic activity) or an activator of PRMT5 (e.g., eliciting an increase in enzymatic activity). In certain embodiments, a small molecule binding compound is of Formula (I):

Ring AA-M-Ring BB.

By “choosing” is meant picking a chemical compound from a chemical library or commercially available source.

By “design” or “designing” is meant to provide a novel molecular structure of, for example, a compound, such as a small molecule, or a polypeptide or nucleic acid that has desired properties or characteristics.

By “identify” or “identifying” is meant to determine a condition, compound, polypeptide, amino acid, or nucleic acid that corresponds to or exhibits a desired characteristic or property.

As used herein the term “inhibit” means to reduce the amount of PRMT5 activity to a level or amount that is statistically significantly less than an initial level, which may be a baseline level of PRMT5 activity.

The term “modulate,” as used herein, means to increase or decrease PRMT5 enzymatic activity.

By “screen” or “screening” is meant to test for in silico, in vitro, or in vivo a compound with a particular characteristic or desired property. These characteristics or desired properties may be chemical, biological, or physical in nature or a combination thereof. For example, in screening for PRMT5 binding compounds the desired characteristics may include, but are not limited to, high affinity intracellular binding to PRMT5, high specificity for binding to one or multiple binding sites on PRMT5, low specificity for binding to one or multiple binding sites on PRMT5, high degree of inhibition of PRMT5 activity, high bioavailability of the compound, efficient cellular uptake of the compound, high solubility of the compound in pharmacological carriers, low pharmacological toxicity of the compound, etc. Screening may be performed in vitro or in vivo using compound libraries, such as small molecule libraries, peptide libraries, DNA libraries, or RNA libraries. Screening in silico may be performed using predefined or randomized screening parameters and data sets, for example, of known test compounds and/or test conditions.

By “select” or “selecting” is meant to provide a pre-existing molecular structure and to choose, for example, from a group of pre-existing compounds, such as a small molecules, polypeptides, or nucleic acids one or more members that have or exhibit a desired property or characteristic.

The term “subject,” as used herein, refers to any animal. In certain embodiments, the subject is a mammal. In certain embodiments, the term “subject”, as used herein, refers to a human (e.g., male, female, adult, or child). The subject may be at any stage of development. The subject may be a transgenic animal and/or experimental animal, e.g. a mammal (mouse, rat, hamster, pig, goat, cow, camel, sheep, cat, dog, etc.), a fish (zebrafish etc.), a nematode (Caenorhabditis elegans etc.), an insect (Drosophila melanogaster etc.), a frog (Xenopus laevis).

By the term “synthesizing” is meant making a chemical structure from precursors by chemical processes. Synthesizing implies making at least one compound, but is not limited to one compound. In certain aspects, synthesizing implies making more than one compound, such as a series of compounds synthesized in an effort to study structure-activity relationships (SAR) using standard chemistry methods, and/or a series of structurally similar compounds made using standard combinatorial techniques.

It will be appreciated that compounds that modulate PRMT5 activity may have chemical structures that can be altered. For example, one or more substituents of identified compounds may be substituted with any number of other substituents or functional moieties. When more than one position in any given structure may be substituted with more than one substituent selected from a specified group, the substituent may be either the same or different at every position. As used herein, the term “substituted” is contemplated to include substitution with all permissible substituents of organic compounds, any of the substituents described herein (for example, aliphatic, alkyl, alkenyl, alkynyl, heteroaliphatic, heterocyclic, aryl, heteroaryl, acyl, oxo, imino, thiooxo, cyano, isocyano, amino, azido, nitro, hydroxyl, thiol, halo, etc.), and any combination thereof (for example, aliphaticamino, heteroaliphaticamino, alkylamino, heteroalkylamino, arylamino, heteroarylamino, alkylaryl, arylalkyl, aliphaticoxy, heteroaliphaticoxy, alkyloxy, heteroalkyloxy, aryloxy, heteroaryloxy, aliphaticthioxy, heteroaliphaticthioxy, alkylthioxy, heteroalkylthioxy, arylthioxy, heteroarylthioxy, acyloxy, and the like) that results in the formation of a stable moiety. Heteroatoms such as nitrogen may have hydrogen substituents and/or any suitable substituent as described herein which satisfy the valencies of the heteroatoms and results in the formation of a stable moiety.

Compounds described herein can comprise one or more asymmetric centers, and thus can exist in various isomeric forms, e.g., enantiomers and/or diastereomers. For example, the compounds described herein can be in the form of an individual enantiomer, diastereomer or geometric isomer, or can be in the form of a mixture of stereoisomers, including racemic mixtures and mixtures enriched in one or more stereoisomer. Isomers can be isolated from mixtures by methods known to those skilled in the art, including chiral high pressure liquid chromatography (HPLC) and the formation and crystallization of chiral salts; or preferred isomers can be prepared by asymmetric syntheses. See, for example, Jacques et al., Enantiomers, Racemates and Resolutions (Wiley Interscience, New York, 1981); Wilen et al., Tetrahedron 33:2725 (1977); Eliel, Stereochemistry of Carbon Compounds (McGraw-Hill, NY, 1962); and Wilen, Tables of Resolving Agents and Optical Resolutions p. 268 (E. L. Eliel, Ed., Univ. of Notre Dame Press, Notre Dame, Ind. 1972). The present disclosure additionally encompasses compounds described herein as individual isomers substantially free of other isomers, and alternatively, as mixtures of various isomers.

It is to be understood that the compounds of the present invention may be depicted as different tautomers. It should also be understood that when compounds have tautomeric forms, all tautomeric forms are intended to be included in the scope of the present invention, and the naming of any compound described herein does not exclude any tautomer form.

Unless otherwise stated, structures depicted herein are also meant to include compounds that differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of hydrogen by deuterium or tritium, replacement of ¹⁹F with ¹⁸F, or the replacement of a carbon by a ¹³C- or ¹⁴C-enriched carbon are within the scope of the disclosure. Such compounds are useful, for example, as analytical tools or probes in biological assays.

The term “aliphatic,” as used herein, includes both saturated and unsaturated, nonaromatic, straight chain (i.e., unbranched), branched, acyclic, and cyclic (i.e., carbocyclic) hydrocarbons. In some embodiments, an aliphatic group is optionally substituted with one or more functional groups. As will be appreciated by one of ordinary skill in the art, “aliphatic” is intended herein to include alkyl, alkenyl, alkynyl, cycloalkyl, and cycloalkenyl moieties.

When a range of values is listed, it is intended to encompass each value and sub-range within the range. For example “C_1-6 alkyl” is intended to encompass, C₁, C₂, C₃, C₄, C₅, C₆, C_1-6, C_1-5, C_1-4, C_1-3, C_1-2, C_2-6, C_2-5, C_2-4, C_2-3, C_3-6, C_3-5, C_3-4, C_4-6, C_4-5, and C_5-6 alkyl.

“Alkyl” refers to a radical of a straight-chain or branched saturated hydrocarbon group having from 1 to 20 carbon atoms (“C_1-20 alkyl”). In some embodiments, an alkyl group has 1 to 10 carbon atoms (“C_1-10 alkyl”). In some embodiments, an alkyl group has 1 to 9 carbon atoms (“C_1-9 alkyl”). In some embodiments, an alkyl group has 1 to 8 carbon atoms (“C_1-8 alkyl”). In some embodiments, an alkyl group has 1 to 7 carbon atoms (“C_1-7 alkyl”). In some embodiments, an alkyl group has 1 to 6 carbon atoms (“C_1-6 alkyl”). In some embodiments, an alkyl group has 1 to 5 carbon atoms (“C_1-5 alkyl”). In some embodiments, an alkyl group has 1 to 4 carbon atoms (“C_1-4 alkyl”). In some embodiments, an alkyl group has 1 to 3 carbon atoms (“C_1-3 alkyl”). In some embodiments, an alkyl group has 1 to 2 carbon atoms (“C_1-2 alkyl”). In some embodiments, an alkyl group has 1 carbon atom (“C₁ alkyl”). In some embodiments, an alkyl group has 2 to 6 carbon atoms (“C_2-6 alkyl”). Examples of C_1-6 alkyl groups include methyl (C₁), ethyl (C₂), n-propyl (C₃), isopropyl (C₃), n-butyl (C₄), tert-butyl (C₄), sec-butyl (C₄), iso-butyl (C₄), n-pentyl (C₅), 3-pentanyl (C₅), amyl (C₅), neopentyl (C₅), 3-methyl-2-butanyl (C₅), tertiary amyl (C₅), and n-hexyl (C₆). Additional examples of alkyl groups include n-heptyl (C₇), n-octyl (C₈) and the like. In certain embodiments, each instance of an alkyl group is independently optionally substituted, e.g., unsubstituted (an “unsubstituted alkyl”) or substituted (a “substituted alkyl”) with one or more substituents. In certain embodiments, the alkyl group is unsubstituted C_1-10 alkyl (e.g., —CH₃). In certain embodiments, the alkyl group is substituted C_1-10 alkyl.

In some embodiments, an alkyl group is substituted with one or more halogens. “Perhaloalkyl” is a substituted alkyl group as defined herein wherein all of the hydrogen atoms are independently replaced by a halogen, e.g., fluoro, bromo, chloro, or iodo. In some embodiments, the alkyl moiety has 1 to 8 carbon atoms (“C_1-8 perhaloalkyl”). In some embodiments, the alkyl moiety has 1 to 6 carbon atoms (“C_1-6 perhaloalkyl”). In some embodiments, the alkyl moiety has 1 to 4 carbon atoms (“C_1-4 perhaloalkyl”). In some embodiments, the alkyl moiety has 1 to 3 carbon atoms (“C_1-3 perhaloalkyl”). In some embodiments, the alkyl moiety has 1 to 2 carbon atoms (“C_1-2 perhaloalkyl”). In some embodiments, all of the hydrogen atoms are replaced with fluoro. In some embodiments, all of the hydrogen atoms are replaced with chloro. Examples of perhaloalkyl groups include —CF₃, —CF₂CF₃, —CF₂CF₂CF₃, —CCl₃, —CFCl₂, —CF₂Cl, and the like.

“Alkenyl” refers to a radical of a straight-chain or branched hydrocarbon group having from 2 to 20 carbon atoms, one or more carbon-carbon double bonds, and no triple bonds (“C_2-20 alkenyl”). In some embodiments, an alkenyl group has 2 to 10 carbon atoms (“C_2-10 alkenyl”). In some embodiments, an alkenyl group has 2 to 9 carbon atoms (“C_2-9 alkenyl”). In some embodiments, an alkenyl group has 2 to 8 carbon atoms (“C_2-8 alkenyl”). In some embodiments, an alkenyl group has 2 to 7 carbon atoms (“C_2-7 alkenyl”). In some embodiments, an alkenyl group has 2 to 6 carbon atoms (“C_2-6 alkenyl”). In some embodiments, an alkenyl group has 2 to 5 carbon atoms (“C_2-5 alkenyl”). In some embodiments, an alkenyl group has 2 to 4 carbon atoms (“C_2-4 alkenyl”). In some embodiments, an alkenyl group has 2 to 3 carbon atoms (“C_2-3 alkenyl”). In some embodiments, an alkenyl group has 2 carbon atoms (“C₂ alkenyl”). The one or more carbon-carbon double bonds can be internal (such as in 2-butenyl) or terminal (such as in 1-butenyl). Examples of C_2-4 alkenyl groups include ethenyl (C₂), 1-propenyl (C₃), 2-propenyl (C₃), 1-butenyl (C₄), 2-butenyl (C₄), butadienyl (C₄), and the like. Examples of C_2-6 alkenyl groups include the aforementioned C_2-4 alkenyl groups as well as pentenyl (C₅), pentadienyl (C₅), hexenyl (C₆), and the like. Additional examples of alkenyl include heptenyl (C₇), octenyl (C₈), octatrienyl (C₈), and the like. In certain embodiments, each instance of an alkenyl group is independently optionally substituted, e.g., unsubstituted (an “unsubstituted alkenyl”) or substituted (a “substituted alkenyl”) with one or more substituents. In certain embodiments, the alkenyl group is unsubstituted C_2-10 alkenyl. In certain embodiments, the alkenyl group is substituted C_2-10 alkenyl.

“Alkynyl” refers to a radical of a straight-chain or branched hydrocarbon group having from 2 to 20 carbon atoms, one or more carbon-carbon triple bonds, and optionally one or more double bonds (“C_2-20 alkynyl”). In some embodiments, an alkynyl group has 2 to 10 carbon atoms (“C_2-10 alkynyl”). In some embodiments, an alkynyl group has 2 to 9 carbon atoms (“C_2-9 alkynyl”). In some embodiments, an alkynyl group has 2 to 8 carbon atoms (“C_2-8 alkynyl”). In some embodiments, an alkynyl group has 2 to 7 carbon atoms (“C_2-7 alkynyl”). In some embodiments, an alkynyl group has 2 to 6 carbon atoms (“C_2-6 alkynyl”). In some embodiments, an alkynyl group has 2 to 5 carbon atoms (“C_2-5 alkynyl”). In some embodiments, an alkynyl group has 2 to 4 carbon atoms (“C_2-4 alkynyl”). In some embodiments, an alkynyl group has 2 to 3 carbon atoms (“C_2-3 alkynyl”). In some embodiments, an alkynyl group has 2 carbon atoms (“C₂ alkynyl”). The one or more carbon-carbon triple bonds can be internal (such as in 2-butynyl) or terminal (such as in 1-butynyl). Examples of C_2-4 alkynyl groups include, without limitation, ethynyl (C₂), 1-propynyl (C₃), 2-propynyl (C₃), 1-butynyl (C₄), 2-butynyl (C₄), and the like. Examples of C_2-6 alkenyl groups include the aforementioned C_2-4 alkynyl groups as well as pentynyl (C₅), hexynyl (C₆), and the like. Additional examples of alkynyl include heptynyl (C₇), octynyl (C₈), and the like. In certain embodiments, each instance of an alkynyl group is independently optionally substituted, e.g., unsubstituted (an “unsubstituted alkynyl”) or substituted (a “substituted alkynyl”) with one or more substituents. In certain embodiments, the alkynyl group is unsubstituted C_2-10 alkynyl. In certain embodiments, the alkynyl group is substituted C_2-10 alkynyl.

“Carbocyclyl” or “carbocyclic” refers to a radical of a non-aromatic cyclic hydrocarbon group having from 3 to 10 ring carbon atoms (“C_3-10 carbocyclyl”) and zero heteroatoms in the non-aromatic ring system. In some embodiments, a carbocyclyl group has 3 to 8 ring carbon atoms (“C_3-8 carbocyclyl”). In some embodiments, a carbocyclyl group has 3 to 6 ring carbon atoms (“C_3-6 carbocyclyl”). In some embodiments, a carbocyclyl group has 3 to 6 ring carbon atoms (“C_3-6 carbocyclyl”). In some embodiments, a carbocyclyl group has 5 to 10 ring carbon atoms (“C_5-10 carbocyclyl”). Exemplary C_3-6 carbocyclyl groups include, without limitation, cyclopropyl (C₃), cyclopropenyl (C₃), cyclobutyl (C₄), cyclobutenyl (C₄), cyclopentyl (C₅), cyclopentenyl (C₅), cyclohexyl (C₆), cyclohexenyl (C₆), cyclohexadienyl (C₆), and the like. Exemplary C_3-8 carbocyclyl groups include, without limitation, the aforementioned C_3-6 carbocyclyl groups as well as cycloheptyl (C₇), cycloheptenyl (C₇), cycloheptadienyl (C₇), cycloheptatrienyl (C₇), cyclooctyl (C₈), cyclooctenyl (C₈), bicyclo[2.2.1]heptanyl (C₇), bicyclo[2.2.2]octanyl (C₈), and the like. Exemplary C_3-10 carbocyclyl groups include, without limitation, the aforementioned C_3-8 carbocyclyl groups as well as cyclononyl (C₉), cyclononenyl (C₉), cyclodecyl (C₁₀), cyclodecenyl (C_m), octahydro-1H-indenyl (C₉), decahydronaphthalenyl (C₁₀), spiro[4.5]decanyl (C₁₀), and the like. As the foregoing examples illustrate, in certain embodiments, the carbocyclyl group is either monocyclic (“monocyclic carbocyclyl”) or contain a fused, bridged or spiro ring system such as a bicyclic system (“bicyclic carbocyclyl”) and can be saturated or can be partially unsaturated. “Carbocyclyl” also includes ring systems wherein the carbocyclyl ring, as defined above, is fused with one or more aryl or heteroaryl groups wherein the point of attachment is on the carbocyclyl ring, and in such instances, the number of carbons continue to designate the number of carbons in the carbocyclic ring system. In certain embodiments, each instance of a carbocyclyl group is independently optionally substituted, e.g., unsubstituted (an “unsubstituted carbocyclyl”) or substituted (a “substituted carbocyclyl”) with one or more substituents. In certain embodiments, the carbocyclyl group is unsubstituted C_3-10 carbocyclyl. In certain embodiments, the carbocyclyl group is a substituted C_3-10 carbocyclyl.

In some embodiments, “carbocyclyl” is a monocyclic, saturated carbocyclyl group having from 3 to 10 ring carbon atoms (“C_3-10 cycloalkyl”). In some embodiments, a cycloalkyl group has 3 to 8 ring carbon atoms (“C_3-8 cycloalkyl”). In some embodiments, a cycloalkyl group has 3 to 6 ring carbon atoms (“C_3-6 cycloalkyl”). In some embodiments, a cycloalkyl group has 5 to 6 ring carbon atoms (“C_5-6 cycloalkyl”). In some embodiments, a cycloalkyl group has 5 to 10 ring carbon atoms (“C_5-10 cycloalkyl”). Examples of C_5-6 cycloalkyl groups include cyclopentyl (C₅) and cyclohexyl (C₅). Examples of C_3-6 cycloalkyl groups include the aforementioned C_5-6 cycloalkyl groups as well as cyclopropyl (C₃) and cyclobutyl (C₄). Examples of C_3-8 cycloalkyl groups include the aforementioned C_3-6 cycloalkyl groups as well as cycloheptyl (C₇) and cyclooctyl (C₈). In certain embodiments, each instance of a cycloalkyl group is independently unsubstituted (an “unsubstituted cycloalkyl”) or substituted (a “substituted cycloalkyl”) with one or more substituents. In certain embodiments, the cycloalkyl group is unsubstituted C_3-10 cycloalkyl. In certain embodiments, the cycloalkyl group is substituted C_3-10 cycloalkyl.

“Heterocyclyl” or “heterocyclic” refers to a radical of a 3- to 10-membered non-aromatic ring system having ring carbon atoms and 1 to 4 ring heteroatoms, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“3-10 membered heterocyclyl”). In heterocyclyl groups that contain one or more nitrogen atoms, the point of attachment can be a carbon or nitrogen atom, as valency permits. A heterocyclyl group can either be monocyclic (“monocyclic heterocyclyl”) or a fused, bridged or spiro ring system such as a bicyclic system (“bicyclic heterocyclyl”), and can be saturated or can be partially unsaturated. Heterocyclyl bicyclic ring systems can include one or more heteroatoms in one or both rings. “Heterocyclyl” also includes ring systems wherein the heterocyclyl ring, as defined above, is fused with one or more carbocyclyl groups wherein the point of attachment is either on the carbocyclyl or heterocyclyl ring, or ring systems wherein the heterocyclyl ring, as defined above, is fused with one or more aryl or heteroaryl groups, wherein the point of attachment is on the heterocyclyl ring, and in such instances, the number of ring members continue to designate the number of ring members in the heterocyclyl ring system. In certain embodiments, each instance of heterocyclyl is independently optionally substituted, e.g., unsubstituted (an “unsubstituted heterocyclyl”) or substituted (a “substituted heterocyclyl”) with one or more substituents. In certain embodiments, the heterocyclyl group is unsubstituted 3-10 membered heterocyclyl. In certain embodiments, the heterocyclyl group is substituted 3-10 membered heterocyclyl.

In some embodiments, a heterocyclyl group is a 5-10 membered non-aromatic ring system having ring carbon atoms and 1-4 ring heteroatoms, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“5-10 membered heterocyclyl”). In some embodiments, a heterocyclyl group is a 5-8 membered non-aromatic ring system having ring carbon atoms and 1-4 ring heteroatoms, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“5-8 membered heterocyclyl”). In some embodiments, a heterocyclyl group is a 5-6 membered non-aromatic ring system having ring carbon atoms and 1-4 ring heteroatoms, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“5-6 membered heterocyclyl”). In some embodiments, the 5-6 membered heterocyclyl has 1-3 ring heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the 5-6 membered heterocyclyl has 1-2 ring heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the 5-6 membered heterocyclyl has one ring heteroatom selected from nitrogen, oxygen, and sulfur.

Exemplary 3-membered heterocyclyl groups containing one heteroatom include, without limitation, azirdinyl, oxiranyl, and thiorenyl. Exemplary 4-membered heterocyclyl groups containing one heteroatom include, without limitation, azetidinyl, oxetanyl, and thietanyl. Exemplary 5-membered heterocyclyl groups containing one heteroatom include, without limitation, tetrahydrofuranyl, dihydrofuranyl, tetrahydrothiophenyl, dihydrothiophenyl, pyrrolidinyl, dihydropyrrolyl, and pyrrolyl-2,5-dione. Exemplary 5-membered heterocyclyl groups containing two heteroatoms include, without limitation, dioxolanyl, oxasulfuranyl, disulfuranyl, and oxazolidin-2-one. Exemplary 5-membered heterocyclyl groups containing three heteroatoms include, without limitation, triazolinyl, oxadiazolinyl, and thiadiazolinyl. Exemplary 6-membered heterocyclyl groups containing one heteroatom include, without limitation, piperidinyl, tetrahydropyranyl, dihydropyridinyl, and thianyl. Exemplary 6-membered heterocyclyl groups containing two heteroatoms include, without limitation, piperazinyl, morpholinyl, dithianyl, and dioxanyl. Exemplary 6-membered heterocyclyl groups containing two heteroatoms include, without limitation, triazinanyl. Exemplary 7-membered heterocyclyl groups containing one heteroatom include, without limitation, azepanyl, oxepanyl and thiepanyl. Exemplary 8-membered heterocyclyl groups containing one heteroatom include, without limitation, azocanyl, oxecanyl, and thiocanyl. Exemplary 5-membered heterocyclyl groups fused to a C₆ aryl ring (also referred to herein as a 5,6-bicyclic heterocyclic ring) include, without limitation, indolinyl, isoindolinyl, dihydrobenzofuranyl, dihydrobenzothienyl, benzoxazolinonyl, and the like. Exemplary 6-membered heterocyclyl groups fused to an aryl ring (also referred to herein as a 6,6-bicyclic heterocyclic ring) include, without limitation, tetrahydroquinolinyl, tetrahydroisoquinolinyl, and the like.

“Aryl” refers to a radical of a monocyclic or polycyclic (e.g., bicyclic or tricyclic) 4n+2 aromatic ring system (e.g., having 6, 10, or 14 it electrons shared in a cyclic array) having 6-14 ring carbon atoms and zero heteroatoms provided in the aromatic ring system (“C_6-14 aryl”). In some embodiments, an aryl group has six ring carbon atoms (“C₆ aryl”; e.g., phenyl). In some embodiments, an aryl group has ten ring carbon atoms (“C₁₀ aryl”; e.g., naphthyl such as 1-naphthyl and 2-naphthyl). In some embodiments, an aryl group has fourteen ring carbon atoms (“C₁₄ aryl”; e.g., anthracyl). “Aryl” also includes ring systems wherein the aryl ring, as defined above, is fused with one or more carbocyclyl or heterocyclyl groups wherein the radical or point of attachment is on the aryl ring, and in such instances, the number of carbon atoms continue to designate the number of carbon atoms in the aryl ring system. In certain embodiments, each instance of an aryl group is independently optionally substituted, e.g., unsubstituted (an “unsubstituted aryl”) or substituted (a “substituted aryl”) with one or more substituents. In certain embodiments, the aryl group is unsubstituted C_6-14 aryl. In certain embodiments, the aryl group is substituted C_6-14 aryl.

“Heteroaryl” refers to a radical of a 5-10 membered monocyclic or bicyclic 4n+2 aromatic ring system (e.g., having 6 or 10 it electrons shared in a cyclic array) having ring carbon atoms and 1-4 ring heteroatoms provided in the aromatic ring system, wherein each heteroatom is independently selected from nitrogen, oxygen and sulfur (“5-10 membered heteroaryl”). In heteroaryl groups that contain one or more nitrogen atoms, the point of attachment can be a carbon or nitrogen atom, as valency permits. Heteroaryl bicyclic ring systems can include one or more heteroatoms in one or both rings. “Heteroaryl” includes ring systems wherein the heteroaryl ring, as defined above, is fused with one or more carbocyclyl or heterocyclyl groups wherein the point of attachment is on the heteroaryl ring, and in such instances, the number of ring members continue to designate the number of ring members in the heteroaryl ring system. “Heteroaryl” also includes ring systems wherein the heteroaryl ring, as defined above, is fused with one or more aryl groups wherein the point of attachment is either on the aryl or heteroaryl ring, and in such instances, the number of ring members designates the number of ring members in the fused (aryl/heteroaryl) ring system. Bicyclic heteroaryl groups wherein one ring does not contain a heteroatom (e.g., indolyl, quinolinyl, carbazolyl, and the like) the point of attachment can be on either ring, e.g., either the ring bearing a heteroatom (e.g., 2-indolyl) or the ring that does not contain a heteroatom (e.g., 5-indolyl).

In some embodiments, a heteroaryl group is a 5-10 membered aromatic ring system having ring carbon atoms and 1-4 ring heteroatoms provided in the aromatic ring system, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“5-10 membered heteroaryl”). In some embodiments, a heteroaryl group is a 5-8 membered aromatic ring system having ring carbon atoms and 1-4 ring heteroatoms provided in the aromatic ring system, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“5-8 membered heteroaryl”). In some embodiments, a heteroaryl group is a 5-6 membered aromatic ring system having ring carbon atoms and 1-4 ring heteroatoms provided in the aromatic ring system, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur (“5-6 membered heteroaryl”). In some embodiments, the 5-6 membered heteroaryl has 1-3 ring heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the 5-6 membered heteroaryl has 1-2 ring heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the 5-6 membered heteroaryl has 1 ring heteroatom selected from nitrogen, oxygen, and sulfur. In certain embodiments, each instance of a heteroaryl group is independently optionally substituted, e.g., unsubstituted (“unsubstituted heteroaryl”) or substituted (“substituted heteroaryl”) with one or more substituents. In certain embodiments, the heteroaryl group is unsubstituted 5-14 membered heteroaryl. In certain embodiments, the heteroaryl group is substituted 5-14 membered heteroaryl.

Exemplary 5-membered heteroaryl groups containing one heteroatom include, without limitation, pyrrolyl, furanyl and thiophenyl. Exemplary 5-membered heteroaryl groups containing two heteroatoms include, without limitation, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, and isothiazolyl. Exemplary 5-membered heteroaryl groups containing three heteroatoms include, without limitation, triazolyl, oxadiazolyl, and thiadiazolyl. Exemplary 5-membered heteroaryl groups containing four heteroatoms include, without limitation, tetrazolyl. Exemplary 6-membered heteroaryl groups containing one heteroatom include, without limitation, pyridinyl. Exemplary 6-membered heteroaryl groups containing two heteroatoms include, without limitation, pyridazinyl, pyrimidinyl, and pyrazinyl. Exemplary 6-membered heteroaryl groups containing three or four heteroatoms include, without limitation, triazinyl and tetrazinyl, respectively. Exemplary 7-membered heteroaryl groups containing one heteroatom include, without limitation, azepinyl, oxepinyl, and thiepinyl. Exemplary 5,6-bicyclic heteroaryl groups include, without limitation, indolyl, isoindolyl, indazolyl, benzotriazolyl, benzothiophenyl, isobenzothiophenyl, benzofuranyl, benzoisofuranyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzoxadiazolyl, benzthiazolyl, benzisothiazolyl, benzthiadiazolyl, indolizinyl, and purinyl. Exemplary 6,6-bicyclic heteroaryl groups include, without limitation, naphthyridinyl, pteridinyl, quinolinyl, isoquinolinyl, cinnolinyl, quinoxalinyl, phthalazinyl, and quinazolinyl.

“Partially unsaturated” refers to a group that includes at least one double or triple bond. The term “partially unsaturated” is intended to encompass rings having multiple sites of unsaturation, but is not intended to include aromatic groups (e.g., aryl or heteroaryl groups) as herein defined. Likewise, “saturated” refers to a group that does not contain a double or triple bond, i.e., contains all single bonds.

In some embodiments, aliphatic, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl groups, as defined herein, are optionally substituted (e.g., “substituted” or “unsubstituted” aliphatic, “substituted” or “unsubstituted” alkyl, “substituted” or “unsubstituted” alkenyl, “substituted” or “unsubstituted” alkynyl, “substituted” or “unsubstituted” carbocyclyl, “substituted” or “unsubstituted” heterocyclyl, “substituted” or “unsubstituted” aryl or “substituted” or “unsubstituted” heteroaryl group). In general, the term “substituted”, whether preceded by the term “optionally” or not, means that at least one hydrogen present on a group (e.g., a carbon or nitrogen atom) is replaced with a permissible substituent, e.g., a substituent which upon substitution results in a stable compound, e.g., a compound which does not spontaneously undergo transformation such as by rearrangement, cyclization, elimination, or other reaction. Unless otherwise indicated, a “substituted” group has a substituent at one or more substitutable positions of the group, and when more than one position in any given structure is substituted, the substituent is either the same or different at each position. The term “substituted” is contemplated to include substitution with all permissible substituents of organic compounds, including any of the substituents described herein that results in the formation of a stable compound. The present disclosure contemplates any and all such combinations in order to arrive at a stable compound. For purposes of this disclosure, heteroatoms such as nitrogen may have hydrogen substituents and/or any suitable substituent as described herein which satisfy the valencies of the heteroatoms and results in the formation of a stable moiety.

Exemplary carbon atom substituents include, but are not limited to, halogen, —CN, —NO₂, —N₃, —SO₂H, —SO₃H, —OH, —OR^aa, —ON(R^bb)₂, —N(R^bb)₂, —N(R^bb)₃⁺X⁻, —N(OR^cc)R^bb, —SH, —SR^aa, —SSR^cc, —C(═O)R^aa, —CO₂H, —CHO, —C(OR^cc)₂, —CO₂R^aa, —OC(═O)R^aa, —OCO₂R^aa, —C(═O)N(R^bb)₂, —OC(═O)N(R^bb)₂, —NR^bbC(═O)R^aa, —NR^bbCO₂R^aa, —NR^bbC(═O)N(R^bb)₂, —C(═NR^bb)R^aa, —C(═NR^bb)OR^aa, —OC(═NR^bb)R^aa, —OC(═NR^bb)OR^aa, —C(═NR^bb)N(R^bb)₂, —OC(═NR^bb)N(R^bb)₂, NR^bbC(═NR^bb)N(R^bb)₂, —C(═O)NR^bbSO₂R^aa, —NR^bbSO₂R^aa, —SO₂N(R^bb)₂, —SO₂R^aa, —SO₂OR^aa, —OSO₂R^aa, S(═O)R^aa, —OS(═O)R^aa, —Si(R^aa)₃, —OSi(R^aa)₃—C(═S)N(R^bb)₂, —C(═O)SR^aa, —C(═S)SR^aa, —SC(═S)SR^aa, —SC(═O)SR^aa, —OC(═O)SR^aa, —SC(═O)OR^aa, —SC(═O)R^aa, —P(═O)₂R^aa, —OP(═O)₂R^aa, —P(═O)(R^aa)₂, —OP(═O)(R^aa)₂, —OP(═O)(OR^aa)₂, —P(═O)₂N(R^bb)₂, —OP(═O)₂N(R^bb)₂, —P(═O)(NR^bb)₂, —OP(═O)(NR^bb)₂, —NR^bbP(═O)(OR^cc)₂, —NR^bbP(═O)(NR^bb)₂, —P(R^cc)₂, —P(R^cc)₃, —OP(R^cc)₂, —OP(R^cc)₃, —B(R^aa)₂, —B(OR^cc)₂, —BR^aa(OR^cc), C_1-10 alkyl, C_1-10 perhaloalkyl, C_2-10 alkenyl, C_2-10 alkynyl, C_3-10 carbocyclyl, 3-14 membered heterocyclyl, C_6-14 aryl, and 5-14 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^dd groups;

or two geminal hydrogens on a carbon atom are replaced with the group ═O, ═S, ═NN(R^bb)₂, ═NNR^bbC(═O)R^aa, ═NNR^bbC(═O)OR^aa, ═NNR^bbS(═O)₂R^aa, ═NR^bb, or ═NOR^cc;

each instance of R^aa is, independently, selected from C_1-10 alkyl, C_1-10 perhaloalkyl, C_2-10 alkenyl, C_2-10 alkynyl, C_3-10 carbocyclyl, 3-14 membered heterocyclyl, C_6-14 aryl, and 5-14 membered heteroaryl, or two R^aa groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^dd groups;

each instance of R^bb is, independently, selected from hydrogen, —OH, —OR^aa, —N(R^cc)₂, —CN, —C(═O)R^aa, —C(═O)N(R^cc)₂, —CO₂R^aa, —SO₂R^aa, —C(═NR^cc)OR^aa, —C(═NR^cc)N(R^cc)₂, —SO₂N(R^cc)₂, —SO₂R^cc, —SO₂OR^cc, —SOR^aa, —C(═S)N(R^cc)₂, —C(═O)SR^cc, —C(═S)SR^cc, —P(═O)₂R^aa, —P(═O)(R^aa)₂, —P(═O)₂N(R^cc)₂, —P(═O)(NR^cc)₂, C_1-10 alkyl, C_1-10 perhaloalkyl, C_2-10 alkenyl, C_2-10 alkynyl, C_3-10 carbocyclyl, 3-14 membered heterocyclyl, C_6-14 aryl, and 5-14 membered heteroaryl, or two R^bb groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^dd groups;

each instance of R^cc is, independently, selected from hydrogen, C_1-10 alkyl, C_1-10 perhaloalkyl, C_2-10 alkenyl, C_2-10 alkynyl, C_3-10 carbocyclyl, 3-14 membered heterocyclyl, C_6-14 aryl, and 5-14 membered heteroaryl, or two R^cc groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^dd groups;

each instance of R^dd is, independently, selected from halogen, —CN, —NO₂, —N₃, —SO₂H, —SO₃H, —OH, —OR^ee, —ON(R^ff)₂, —N(R^ff)₂, —N(R^ff)₃⁺X⁻, —N(OR^ee)R^ff, —SH, —SR^ee, —SSR^ee, —C(═O)R^ee, —CO₂H, —CO₂R^ee, —OC(═O)R^ee, —OCO₂R^ee, —C(═O)N(R^ff)₂, —OC(═O)N(R^ff)₂, —NR^ffC(═O)R^ee, —NR^ffCO₂R^ee, —NR^ffC(═O)N(R^ff)₂, —C(═NR^ff)OR^ee, —OC(═NR^ff)R^ee, —OC(═NR^ff)OR^ee, —C(═NR^ff)N(R^ff)₂, —OC(═NR^ff)N(R)₂, —NR^ffC(═NR^ff)N(R^ff)₂, —NR^ffSO₂R^ee, —SO₂N(R^ff)₂, —SO₂R^ee, —SO₂OR^ee, —OSO₂R^ee, —S(═O)R^ee, —Si(R^ee)₃, —OSi(R^ee)₃, —C(═S)N(R^ff)₂, —C(═O)SR^ee, —C(═S)SR^ee, —SC(═S)SR^ee, —P(═O)₂R^ee, —P(═O)(R^ee)₂, —OP(═O)(R^ee)₂, —OP(═O)(OR^ee)₂, C_1-6 alkyl, C_1-6 perhaloalkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_3-10 carbocyclyl, 3-10 membered heterocyclyl, C_6-10 aryl, 5-10 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^gg groups, or two geminal R^dd substituents can be joined to form ═O or ═S;

each instance of R^ee is, independently, selected from C_1-6 alkyl, C_1-6 perhaloalkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_3-10 carbocyclyl, C_6-10 aryl, 3-10 membered heterocyclyl, and 3-10 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^gg groups;

each instance of R^ff is, independently, selected from hydrogen, C_1-6 alkyl, C_1-6 perhaloalkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_3-10 carbocyclyl, 3-10 membered heterocyclyl, C_6-10 aryl and 5-10 membered heteroaryl, or two e groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^gg groups; and

each instance of R^gg is, independently, halogen, —CN, —NO₂, —N₃, —SO₂H, —SO₃H, —OH, —OC_1-6 alkyl, —ON(C_1-6 alkyl)₂, —N(C_1-6 alkyl)₂, —N(C_1-6 alkyl)₃⁺X⁻, —NH(C_1-6 alkyl)₂⁺X⁻, —NH₂(C_1-6 alkyl)⁺X⁻, —NH₃⁺X⁻, —N(OC_1-6 alkyl)(C_1-6 alkyl), —N(OH)(C_1-6 alkyl), —NH(OH), —SH, —SC_1-6 alkyl, —SS(C_1-6 alkyl), —C(═O)(C_1-6 alkyl), —CO₂H, —CO₂(C_1-6 alkyl), —OC(═O)(C_1-6 alkyl), —OCO₂(C_1-6 alkyl), —C(═O)NH₂, —C(═O)N(C_1-6 alkyl)₂, —OC(═O)NH(C_1-6 alkyl), —NHC(═O)(C₁ alkyl), —N(C_1-6 alkyl)C(═O)(C_1-6 alkyl), —NHCO₂(C_1-6 alkyl), —NHC(═O)N(C_1-6 alkyl)₂, —NHC(═O)NH(C_1-6 alkyl), —NHC(═O)NH₂, —C(═NH)O(C_1-6 alkyl), —OC(═NH)(C_1-6 alkyl), —OC(═NH)OC_1-6 alkyl, —C(═NH)N(C_1-6 alkyl)₂, —C(═NH)NH(C_1-6 alkyl), —C(═NH)NH₂, —OC(═NH)N(C_1-6 alkyl)₂, —OC(NH)NH(C_1-6 alkyl), —OC(NH)NH₂, —NHC(NH)N(C_1-6 alkyl)₂, —NHC(═NH)NH₂, —NHSO₂(C_1-6 alkyl), —SO₂N(C_1-6 alkyl)₂, —SO₂NH(C_1-6 alkyl), —SO₂NH₂, —SO₂C_1-6 alkyl, —SO₂OC_1-6 alkyl, —OSO₂C_1-6 alkyl, —SOC_1-6 alkyl, —Si(C_1-6 alkyl)₃, —OSi(C_1-6 alkyl)₃-C(═S)N(C_1-6 alkyl)₂, C(═S)NH(C_1-6 alkyl), C(═S)NH₂, —C(═O)S(C_1-6 alkyl), —C(═S)SC_1-6 alkyl, —SC(═S)SC_1-6 alkyl, —P(═O)₂(C_1-6 alkyl), —P(═O)(C_1-6 alkyl)₂, —OP(═O)(C_1-6 alkyl)₂, —OP(═O)(OC_1-6 alkyl)₂, C_1-6 alkyl, C_1-6 perhaloalkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_3-10 carbocyclyl, C_6-10 aryl, 3-10 membered heterocyclyl, 5-10 membered heteroaryl; or two geminal R^gg substituents can be joined to form ═O or ═S; wherein X⁻ is a counterion.

A “counterion” or “anionic counterion” is a negatively charged group associated with a cationic quaternary amino group in order to maintain electronic neutrality. Exemplary counterions include halide ions (e.g., F⁻, Cl⁻, Br⁻, I⁻), NO₃⁻, ClO₄⁻, OH⁻, H₂PO₄⁻, HSO₄⁻, sulfonate ions (e.g., methansulfonate, trifluoromethanesulfonate, p-toluenesulfonate, benzenesulfonate, 10-camphor sulfonate, naphthalene-2-sulfonate, naphthalene-1-sulfonic acid-5-sulfonate, ethan-1-sulfonic acid-2-sulfonate, and the like), and carboxylate ions (e.g., acetate, ethanoate, propanoate, benzoate, glycerate, lactate, tartrate, glycolate, and the like).

“Halo” or “halogen” refers to fluorine (fluoro, —F), chlorine (chloro, —Cl), bromine (bromo, —Br), or iodine (iodo, —I).

Nitrogen atoms can be substituted or unsubstituted as valency permits, and include primary, secondary, tertiary, and quarternary nitrogen atoms. Exemplary nitrogen atom substitutents include, but are not limited to, hydrogen, —OH, —OR^aa, —N(R^cc)₂, —CN, —C(═O)R^aa, —C(═O)N(R^cc)₂, —CO₂R^aa, —SO₂R^aa, —C(═NR^bb)R^aa, —C(═NR^cc)OR^aa, —C(═NR^cc)N(R^cc)₂, —SO₂N(R^cc)₂, —SO₂R^cc, —SO₂OR^cc, —SOR^aa, —C(═S)N(R^cc)₂, —C(═O)SR^cc, —C(═S)SR^cc, —P(═O)₂R^aa, —P(═O)(R^aa)₂, —P(═O)₂N(R^cc)₂, —P(═O)(NR^cc)₂, C_1-10 alkyl, C_1-10 perhaloalkyl, C_2-10 alkenyl, C_2-10 alkynyl, C_3-10 carbocyclyl, 3-14 membered heterocyclyl, C_6-14 aryl, and 5-14 membered heteroaryl, or two R^cc groups attached to a nitrogen atom are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^dd groups, and wherein R^aa, R^bb, R^cc and R^dd are as defined above.

In certain embodiments, the substituent present on a nitrogen atom is a nitrogen protecting group (also referred to as an amino protecting group). Nitrogen protecting groups include, but are not limited to, —OH, —OR^aa, —N(R^cc)₂, —C(═O)R^aa, —C(═O)N(R^cc)₂, —CO₂R^aa, —SO₂R^aa, —C(═NR^cc)R^aa, —C(═NR^cc)OR^aa, —C(═NR^cc)N(R^cc)₂, —SO₂N(R^cc)₂, —SO₂R^cc, —SO₂OR^cc, —SOR^aa, C(═S)N(R^cc)₂, —C(═O)SR^cc, —C(═S)SR^cc, C_1-10 alkyl (e.g., aralkyl, heteroaralkyl), C_2-10 alkenyl, C_2-10 alkynyl, C_3-10 carbocyclyl, 3-14 membered heterocyclyl, C_6-14 aryl, and 5-14 membered heteroaryl groups, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aralkyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 R^dd groups, and wherein R^aa, R^bb, R^cc, and R^dd are as defined herein. Nitrogen protecting groups are well known in the art and include those described in detail in Protecting Groups in Organic Synthesis, T. W. Greene and P. G. M. Wuts, 3^rd edition, John Wiley & Sons, 1999, incorporated herein by reference.

Amide nitrogen protecting groups (e.g., —C(═O)R^aa) include, but are not limited to, formamide, acetamide, chloroacetamide, trichloroacetamide, trifluoroacetamide, phenylacetamide, 3-phenylpropanamide, picolinamide, 3-pyridylcarboxamide, N-benzoylphenylalanyl derivative, benzamide, p-phenylbenzamide, o-nitophenylacetamide, o-nitrophenoxyacetamide, acetoacetamide, (N′-dithiobenzyloxyacylamino)acetamide, 3-(p-hydroxyphenyl)propanamide, 3-(o-nitrophenyl)propanamide, 2-methyl-2-(o-nitrophenoxy)propanamide, 2-methyl-2-(o-phenylazophenoxy)propanamide, 4-chlorobutanamide, 3-methyl-3-nitrobutanamide, o-nitrocinnamide, N-acetylmethionine, o-nitrobenzamide, and o-(benzoyloxymethyl)benzamide.

Carbamate nitrogen protecting groups (e.g., —C(═O)OR^aa) include, but are not limited to, methyl carbamate, ethyl carbamante, 9-fluorenylmethyl carbamate (Fmoc), 9-(2-sulfo)fluorenylmethyl carbamate, 9-(2,7-dibromo)fluoroenylmethyl carbamate, 2,7-di-t-butyl-[9-(10,10-dioxo-10,10,10,10-tetrahydrothioxanthyl)]methyl carbamate (DBD-Tmoc), 4-methoxyphenacyl carbamate (Phenoc), 2,2,2-trichloroethyl carbamate (Troc), 2-trimethylsilylethyl carbamate (Teoc), 2-phenylethyl carbamate (hZ), 1-(1-adamantyl)-1-methylethyl carbamate (Adpoc), 1,1-dimethyl-2-haloethyl carbamate, 1,1-dimethyl-2,2-dibromoethyl carbamate (DB-t-BOC), 1,1-dimethyl-2,2,2-trichloroethyl carbamate (TCBOC), 1-methyl-1-(4-biphenylyl)ethyl carbamate (Bpoc), 1-(3,5-di-t-butylphenyl)-1-methylethyl carbamate (t-Bumeoc), 2-(2′- and 4′-pyridyl)ethyl carbamate (Pyoc), 2-(N,N-dicyclohexylcarboxamido)ethyl carbamate, t-butyl carbamate (BOC), 1-adamantyl carbamate (Adoc), vinyl carbamate (Voc), allyl carbamate (Alloc), 1-isopropylallyl carbamate (Ipaoc), cinnamyl carbamate (Coc), 4-nitrocinnamyl carbamate (Noc), 8-quinolyl carbamate, N-hydroxypiperidinyl carbamate, alkyldithio carbamate, benzyl carbamate (Cbz), p-methoxybenzyl carbamate (Moz), p-nitobenzyl carbamate, p-bromobenzyl carbamate, p-chlorobenzyl carbamate, 2,4-dichlorobenzyl carbamate, 4-methylsulfinylbenzyl carbamate (Msz), 9-anthrylmethyl carbamate, diphenylmethyl carbamate, 2-methylthioethyl carbamate, 2-methylsulfonylethyl carbamate, 2-(p-toluenesulfonyl)ethyl carbamate, [2-(1,3-dithianyl)]methyl carbamate (Dmoc), 4-methylthiophenyl carbamate (Mtpc), 2,4-dimethylthiophenyl carbamate (Bmpc), 2-phosphonioethyl carbamate (Peoc), 2-triphenylphosphonioisopropyl carbamate (Ppoc), 1,1-dimethyl-2-cyanoethyl carbamate, m-chloro-p-acyloxybenzyl carbamate, p-(dihydroxyboryl)benzyl carbamate, 5-benzisoxazolylmethyl carbamate, 2-(trifluoromethyl)-6-chromonylmethyl carbamate (Tcroc), m-nitrophenyl carbamate, 3,5-dimethoxybenzyl carbamate, o-nitrobenzyl carbamate, 3,4-dimethoxy-6-nitrobenzyl carbamate, phenyl(o-nitrophenyl)methyl carbamate, t-amyl carbamate, S-benzyl thiocarbamate, p-cyanobenzyl carbamate, cyclobutyl carbamate, cyclohexyl carbamate, cyclopentyl carbamate, cyclopropylmethyl carbamate, p-decyloxybenzyl carbamate, 2,2-dimethoxyacylvinyl carbamate, o-(N,N-dimethylcarboxamido)benzyl carbamate, 1,1-dimethyl-3-(N,N-dimethylcarboxamido)propyl carbamate, 1,1-dimethylpropynyl carbamate, di(2-pyridyl)methyl carbamate, 2-furanylmethyl carbamate, 2-iodoethyl carbamate, isoborynl carbamate, isobutyl carbamate, isonicotinyl carbamate, p-(p′-methoxyphenylazo)benzyl carbamate, 1-methylcyclobutyl carbamate, 1-methylcyclohexyl carbamate, 1-methyl-1-cyclopropylmethyl carbamate, 1-methyl-1-(3,5-dimethoxyphenyl)ethyl carbamate, 1-methyl-1-(p-phenylazophenyl)ethyl carbamate, 1-methyl-1-phenylethyl carbamate, 1-methyl-1-(4-pyridyl)ethyl carbamate, phenyl carbamate, p-(phenylazo)benzyl carbamate, 2,4,6-tri-t-butylphenyl carbamate, 4-(trimethylammonium)benzyl carbamate, and 2,4,6-trimethylbenzyl carbamate.

Sulfonamide nitrogen protecting groups (e.g., —S(═O)₂R^aa) include, but are not limited to, p-toluenesulfonamide (Ts), benzenesulfonamide, 2,3,6,-trimethyl-4-methoxybenzenesulfonamide (Mtr), 2,4,6-trimethoxybenzenesulfonamide (Mtb), 2,6-dimethyl-4-methoxybenzenesulfonamide (Pme), 2,3,5,6-tetramethyl-4-methoxybenzenesulfonamide (Mte), 4-methoxybenzenesulfonamide (Mbs), 2,4,6-trimethylbenzenesulfonamide (Mts), 2,6-dimethoxy-4-methylbenzenesulfonamide (iMds), 2,2,5,7,8-pentamethylchroman-6-sulfonamide (Pmc), methanesulfonamide (Ms), β-trimethylsilylethanesulfonamide (SES), 9-anthracenesulfonamide, 4-(4′,8′-dimethoxynaphthylmethyl)benzenesulfonamide (DNMBS), benzylsulfonamide, trifluoromethylsulfonamide, and phenacylsulfonamide.

Other nitrogen protecting groups include, but are not limited to, phenothiazinyl-(10)-acyl derivative, N′-p-toluenesulfonylaminoacyl derivative, N′-phenylaminothioacyl derivative, N-benzoylphenylalanyl derivative, N-acetylmethionine derivative, 4,5-diphenyl-3-oxazolin-2-one, N-phthalimide, N-dithiasuccinimide (Dts), N-2,3-diphenylmaleimide, N-2,5-dimethylpyrrole, N-1,1,4,4-tetramethyldisilylazacyclopentane adduct (STABASE), 5-substituted 1,3-dimethyl-1,3,5-triazacyclohexan-2-one, 5-substituted 1,3-dibenzyl-1,3,5-triazacyclohexan-2-one, 1-substituted 3,5-dinitro-4-pyridone, N-methylamine, N-allylamine, N-[2-(trimethylsilyl)ethoxy]methylamine (SEM), N-3-acetoxypropylamine, N-(1-isopropyl-4-nitro-2-oxo-3-pyroolin-3-yl)amine, quaternary ammonium salts, N-benzylamine, N-di(4-methoxyphenyl)methylamine, N-5-dibenzosuberylamine, N-triphenylmethylamine (Tr), N-[(4-methoxyphenyl)diphenylmethyl]amine (MMTr), N-9-phenylfluorenylamine (PhF), N-2,7-dichloro-9-fluorenylmethyleneamine, N-ferrocenylmethylamino (Fcm), N-2-picolylamino N′-oxide, N-1,1-dimethylthiomethyleneamine, N-benzylideneamine, N-p-methoxybenzylideneamine, N-diphenylmethyleneamine, N-[(2-pyridyl)mesityl]methyleneamine, N—(N′,N′-dimethylaminomethylene)amine, N,N′-isopropylidenediamine, N-p-nitrobenzylideneamine, N-salicylideneamine, N-5-chlorosalicylideneamine, N-(5-chloro-2-hydroxyphenyl)phenylmethyleneamine, N-cyclohexylideneamine, N-(5,5-dimethyl-3-oxo-1-cyclohexenyl)amine, N-borane derivative, N-diphenylborinic acid derivative, N-[phenyl(pentaacylchromium- or tungsten)acyl]amine, N-copper chelate, N-zinc chelate, N-nitroamine, N-nitrosoamine, amine N-oxide, diphenylphosphinamide (Dpp), dimethylthiophosphinamide (Mpt), diphenylthiophosphinamide (Ppt), dialkyl phosphoramidates, dibenzyl phosphoramidate, diphenyl phosphoramidate, benzenesulfenamide, o-nitrobenzenesulfenamide (Nps), 2,4-dinitrobenzenesulfenamide, pentachlorobenzenesulfenamide, 2-nitro-4-methoxybenzenesulfenamide, triphenylmethylsulfenamide, and 3-nitropyridinesulfenamide (Npys).

In certain embodiments, the substituent present on an oxygen atom is an oxygen protecting group (also referred to as a hydroxyl protecting group). Oxygen protecting groups include, but are not limited to, —R^aa, —N(R^bb)₂, —C(═O)SR^aa, —C(═O)R^aa, —CO₂R^aa, —C(═O)N(R^bb)₂, —C(═NR^bb)R^aa, —C(═NR^bb)OR^aa, —C(═NR^bb)N(R^bb)₂, —S(═O)R^aa, —SO₂R^aa, Si(R^aa)₃, —P(R^cc)₂, —P(R^cc)₃, —P(═O)₂R^aa, —P(═O)(R^aa)₂, —P(═O)(OR^cc)₂, —P(═O)₂N(R^bb)₂, and —P(═O)(NR^bb)₂, wherein R^bb, and R^cc are as defined herein. Oxygen protecting groups are well known in the art and include those described in detail in Protecting Groups in Organic Synthesis, T. W. Greene and P. G. M. Wuts, 3^rd edition, John Wiley & Sons, 1999, incorporated herein by reference.

Exemplary oxygen protecting groups include, but are not limited to, methyl, methoxylmethyl (MOM), methylthiomethyl (MTM), t-butylthiomethyl, (phenyldimethylsilyl)methoxymethyl (SMOM), benzyloxymethyl (BOM), p-methoxybenzyloxymethyl (PMBM), (4-methoxyphenoxy)methyl (p-AOM), guaiacolmethyl (GUM), t-butoxymethyl, 4-pentenyloxymethyl (POM), siloxymethyl, 2-methoxyethoxymethyl (MEM), 2,2,2-trichloroethoxymethyl, bis(2-chloroethoxy)methyl, 2-(trimethylsilyl)ethoxymethyl (SEMOR), tetrahydropyranyl (THP), 3-bromotetrahydropyranyl, tetrahydrothiopyranyl, 1-methoxycyclohexyl, 4-methoxytetrahydropyranyl (MTHP), 4-methoxytetrahydrothiopyranyl, 4-methoxytetrahydrothiopyranyl S,S-dioxide, 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (CTMP), 1,4-dioxan-2-yl, tetrahydrofuranyl, tetrahydrothiofuranyl, 2,3,3a,4,5,6,7,7a-octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl, 1-ethoxyethyl, 1-(2-chloroethoxy)ethyl, 1-methyl-1-methoxyethyl, 1-methyl-1-benzyloxyethyl, 1-methyl-1-benzyloxy-2-fluoroethyl, 2,2,2-trichloroethyl, 2-trimethylsilylethyl, 2-(phenylselenyl)ethyl, t-butyl, allyl, p-chlorophenyl, p-methoxyphenyl, 2,4-dinitrophenyl, benzyl (Bn), p-methoxybenzyl, 3,4-dimethoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, p-halobenzyl, 2,6-dichlorobenzyl, p-cyanobenzyl, p-phenylbenzyl, 2-picolyl, 4-picolyl, 3-methyl-2-picolyl N-oxido, diphenylmethyl, p,p′-dinitrobenzhydryl, 5-dibenzosuberyl, triphenylmethyl, α-naphthyldiphenylmethyl, p-methoxyphenyldiphenylmethyl, di(p-methoxyphenyl)phenylmethyl, tri(p-methoxyphenyl)methyl, 4-(4′-bromophenacyloxyphenyl)diphenylmethyl, 4,4′,4″-tris(4,5-dichlorophthalimidophenyl)methyl, 4,4′,4″-tris(levulinoyloxyphenyl)methyl, 4,4′,4″-tris(benzoyloxyphenyl)methyl, 3-(imidazol-1-yl)bis(4′,4″-dimethoxyphenyl)methyl, 1,1-bis(4-methoxyphenyl)-1′-pyrenylmethyl, 9-anthryl, 9-(9-phenyl)xanthenyl, 9-(9-phenyl-10-oxo)anthryl, 1,3-benzodisulfuran-2-yl, benzisothiazolyl S,S-dioxido, trimethylsilyl (TMS), triethylsilyl (TES), triisopropylsilyl (TIPS), dimethylisopropylsilyl (IPDMS), diethylisopropylsilyl (DEIPS), dimethylthexylsilyl, t-butyldimethylsilyl (TBDMS), t-butyldiphenylsilyl (TBDPS), tribenzylsilyl, tri-p-xylylsilyl, triphenylsilyl, diphenylmethylsilyl (DPMS), t-butylmethoxyphenylsilyl (TBMPS), formate, benzoylformate, acetate, chloroacetate, dichloroacetate, trichloroacetate, trifluoroacetate, methoxyacetate, triphenylmethoxyacetate, phenoxyacetate, p-chlorophenoxyacetate, 3-phenylpropionate, 4-oxopentanoate (levulinate), 4,4-(ethylenedithio)pentanoate (levulinoyldithioacetal), pivaloate, adamantoate, crotonate, 4-methoxycrotonate, benzoate, p-phenylbenzoate, 2,4,6-trimethylbenzoate (mesitoate), alkyl methyl carbonate, 9-fluorenylmethyl carbonate (Fmoc), alkyl ethyl carbonate, alkyl 2,2,2-trichloroethyl carbonate (Troc), 2-(trimethylsilyl)ethyl carbonate (TMSEC), 2-(phenylsulfonyl)ethyl carbonate (Psec), 2-(triphenylphosphonio)ethyl carbonate (Peoc), alkyl isobutyl carbonate, alkyl vinyl carbonate alkyl allyl carbonate, alkyl p-nitrophenyl carbonate, alkyl benzyl carbonate, alkyl p-methoxybenzyl carbonate, alkyl 3,4-dimethoxybenzyl carbonate, alkyl o-nitrobenzyl carbonate, alkyl p-nitrobenzyl carbonate, alkyl S-benzyl thiocarbonate, 4-ethoxy-1-napththyl carbonate, methyl dithiocarbonate, 2-iodobenzoate, 4-azidobutyrate, 4-nitro-4-methylpentanoate, o-(dibromomethyl)benzoate, 2-formylbenzenesulfonate, 2-(methylthiomethoxy)ethyl, 4-(methylthiomethoxy)butyrate, 2-(methylthiomethoxymethyl)benzoate, 2,6-dichloro-4-methylphenoxyacetate, 2,6-dichloro-4-(1,1,3,3-tetramethylbutyl)phenoxyacetate, 2,4-bis(1,1-dimethylpropyl)phenoxyacetate, chlorodiphenylacetate, isobutyrate, monosuccinoate, (E)-2-methyl-2-butenoate, o-(methoxyacyl)benzoate, α-naphthoate, nitrate, alkyl N,N,N′,N′-tetramethylphosphorodiamidate, alkyl N-phenylcarbamate, borate, dimethylphosphinothioyl, alkyl 2,4-dinitrophenylsulfenate, sulfate, methanesulfonate (mesylate), benzylsulfonate, and tosylate (Ts).

In certain embodiments, the substituent present on a sulfur atom is a sulfur protecting group (also referred to as a thiol protecting group). Sulfur protecting groups include, but are not limited to, —R^aa, —N(R^bb)₂, —C(═O)SR^aa, —C(═O)R^aa, —CO₂R^aa, —C(═O)N(R^bb)₂, —C(═NR^bb)R^aa, —C(═NR^bb)OR^aa, —C(═NR^bb)N(R^bb)₂, —S(═O)R^aa, —SO₂R^aa, —Si(R^aa)₃, —P(R^cc)₂, —P(R^cc)₃, —P(═O)₂R^aa, —P(═O)(R^aa)₂, —P(═O)(OR^cc)₂, —P(═O)₂N(R^bb)₂, and —P(═O)(NR^bb)₂, wherein R^aa, R^bb, and R^cc are as defined herein. Sulfur protecting groups are well known in the art and include those described in detail in Protecting Groups in Organic Synthesis, T. W. Greene and P. G. M. Wuts, 3^rd edition, John Wiley & Sons, 1999, incorporated herein by reference.

These and other exemplary substituents are described in more detail in the Detailed Description, Examples, and claims. The present disclosure is not intended to be limited in any manner by the above exemplary listing of substituents.

OTHER DEFINITIONS

“Pharmaceutically acceptable salt” refers to those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and other animals without undue toxicity, irritation, allergic response, and the like, and are commensurate with a reasonable benefit/risk ratio. Pharmaceutically acceptable salts are well known in the art. For example, Berge et al. describe pharmaceutically acceptable salts in detail in J. Pharmaceutical Sciences (1977) 66:1-19. Pharmaceutically acceptable salts of the compounds describe herein include those derived from suitable inorganic and organic acids and bases. Examples of pharmaceutically acceptable, nontoxic acid addition salts are salts of an amino group formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid and perchloric acid or with organic acids such as acetic acid, oxalic acid, maleic acid, tartaric acid, citric acid, succinic acid, or malonic acid or by using other methods used in the art such as ion exchange. Other pharmaceutically acceptable salts include adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, formate, fumarate, glucoheptonate, glycerophosphate, gluconate, hemisulfate, heptanoate, hexanoate, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, p-toluenesulfonate, undecanoate, valerate salts, and the like. Salts derived from appropriate bases include alkali metal, alkaline earth metal, ammonium and N⁺(C_1-4alkyl)₄ salts. Representative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and the like. Further pharmaceutically acceptable salts include, when appropriate, quaternary salts.

A “subject” to which administration is contemplated includes, but is not limited to, humans (e.g., a male or female of any age group, e.g., a pediatric subject (e.g, infant, child, adolescent) or adult subject (e.g., young adult, middle-aged adult or senior adult)) and/or other non-human animals, for example, non-human mammals (e.g., primates (e.g., cynomolgus monkeys, rhesus monkeys); commercially relevant mammals such as cattle, pigs, horses, sheep, goats, cats, and/or dogs), birds (e.g., commercially relevant birds such as chickens, ducks, geese, and/or turkeys), rodents (e.g., rats and/or mice), reptiles, amphibians, and fish. In certain embodiments, the non-human animal is a mammal. The non-human animal may be a male or female at any stage of development. A non-human animal may be a transgenic animal.

“Condition,” “disease,” and “disorder” are used interchangeably herein.

“Treat,” “treating” and “treatment” encompasses an action that occurs while a subject is suffering from a condition which reduces the severity of the condition or retards or slows the progression of the condition (“therapeutic treatment”). “Treat,” “treating” and “treatment” also encompasses an action that occurs before a subject begins to suffer from the condition and which inhibits or reduces the severity of the condition (“prophylactic treatment”).

An “effective amount” of a compound refers to an amount sufficient to elicit the desired biological response, e.g., treat the condition. As will be appreciated by those of ordinary skill in this art, the effective amount of a compound described herein may vary depending on such factors as the desired biological endpoint, the pharmacokinetics of the compound, the condition being treated, the mode of administration, and the age and health of the subject. An effective amount encompasses therapeutic and prophylactic treatment.

A “therapeutically effective amount” of a compound is an amount sufficient to provide a therapeutic benefit in the treatment of a condition or to delay or minimize one or more symptoms associated with the condition. A therapeutically effective amount of a compound means an amount of therapeutic agent, alone or in combination with other therapies, which provides a therapeutic benefit in the treatment of the condition. The term “therapeutically effective amount” can encompass an amount that improves overall therapy, reduces or avoids symptoms or causes of the condition, or enhances the therapeutic efficacy of another therapeutic agent.

A “prophylactically effective amount” of a compound is an amount sufficient to prevent a condition, or one or more symptoms associated with the condition or prevent its recurrence. A prophylactically effective amount of a compound means an amount of a therapeutic agent, alone or in combination with other agents, which provides a prophylactic benefit in the prevention of the condition. The term “prophylactically effective amount” can encompass an amount that improves overall prophylaxis or enhances the prophylactic efficacy of another prophylactic agent.

As used herein, the term “methyltransferase” represents transferase class enzymes that are able to transfer a methyl group from a donor molecule to an acceptor molecule, e.g., an amino acid residue of a protein or a nucleotide of a DNA molecule. Methytransferases typically use the reactive methyl group bound to sulfur in S-adenosyl methionine (SAM) as the methyl donor. In some embodiments, a methyltransferase described herein is a protein methyltransferase. In some embodiments, a methyltransferase described herein is a histone methyltransferase. Histone methyltransferases (HMT) are histone-modifying enzymes, (including histone-lysine N-methyltransferase and histone-arginine N-methyltransferase), that catalyze the transfer of one or more methyl groups to lysine and arginine residues of histone proteins. In certain embodiments, a methyltransferase described herein is a histone-arginine N-methyltransferase.

Protein arginine methyltransferase 5 (PRMT5) catalyzes the addition of two methyl groups to the two w-guanidino nitrogen atoms of arginine, resulting in ω-NG, N′G symmetric dimethylation of arginine (sDMA) of the target protein. PRMT5 functions in the nucleus as well as in the cytoplasm, and its substrates include histones, spliceosomal proteins, transcription factors (See e.g., Sun et al., 2011, PNAS 108: 20538-20543). PRMT5 generally functions as part of a molecule weight protein complex. While the protein complexes of PRMT5 can have a variety of components, they generally include the protein MEP50 (methylosome protein 50). In addition, PRMT5 acts in conjunction with cofactor SAM (S-adenosyl methionine).

It was surprisingly found that compounds with specific structural elements can bind PRMT5 and are effective in inhibiting the biological function of PRMT5 (e.g., have a low IC₅₀ value). It is shown herein that compounds that have two aromatic ring structures separated by a flexible linker can inhibit the function of PRMT5 if the compound can engage in certain interactions with amino acids in the active site of PRMT5. In some embodiments, the disclosure provides compounds of the formula Ring AA-M-Ring BB, wherein Ring AA and Ring BB are aromatic ring systems, and wherein M is a linker that allows for the planes of Ring AA and Ring BB to be at about 90° relative to each other. As shown herein, compounds of the formula Ring AA-M-Ring BB that can minimally interact with certain moieties (e.g., SAM and certain amino acids) in the active site of PRMT5 can inhibit the function of PRMT5. In some embodiments compounds of the formula Ring AA-M-Ring BB can form a pi-cation interaction with one or more amino acids in the active site of PRMT5.

In some embodiments Ring BB can form a pi-cation interaction with one or more amino acids in the active site of PRMT5. In some embodiments compounds of the formula Ring AA-M-Ring BB can form a pi-stacking interaction with one or more amino acids in the active site of PRMT5. In some embodiments Ring BB can form a pi-stacking interaction with one or more amino acids in the active site of PRMT5. In some embodiments, the compounds interact with SAM or Phe327 of the active site of PRMT5. In some embodiments, the compounds interact with SAM and Phe327 of the active site of PRMT5. In some embodiments, as provided herein, compounds of the formula Ring AA-M-Ring BB can undergo a cation-pi interaction with SAM through the aromatic ring system in Ring BB. In some embodiments, as provided herein, compounds of the formula Ring AA-M-Ring BB can interact with Phe327 (e.g., through pi stacking) through the aromatic ring system in Ring BB. In some embodiments, as provided herein, compounds of the formula Ring AA-M-Ring BB can inhibit the action of PRMT5 because Ring BB interacts with SAM and Phe327 and because the flexible linker allows for the second aromatic ring system (Ring AA) to interact with other residues in the active site of PRMT5 (e.g., Phe580). In some embodiments, such compounds can inhibit PRMT5 with an IC₅₀ of 100 nM or lower. In some embodiments, such compounds can inhibit PRMT5 with an IC₅₀ of 50 nM or lower. In some embodiments, such compounds can inhibit PRMT5 with an IC₅₀ of 10 nM or lower. In some embodiments, such compounds can inhibit PRMT5 with an IC₅₀ of 1 nM or lower.

In one aspect, the disclosure provides a compound that can bind PRMT5, wherein the compound has the formula:

Ring AA-M-Ring BB;

wherein

Ring AA is an optionally substituted aromatic moiety;

M is an aliphatic linker; and

Ring BB is an aromatic moiety capable of undergoing a pi-cation interaction with S-adenosyl methionine (SAM) and capable of undergoing a pi-stacking interaction with Phe327 of PRMT5;

wherein the planes of Ring A and Ring B are at an angle between 75° and 105° relative to each other. In some embodiments, the compound has an IC₅₀ for PRMT5 of less than 100 nM.

In addition to interacting with SAM and Phe327 the Ring AA-M-Ring BB compounds provided herein may interact with additional amino acids in the active site of PRMT5 such as Leu319, Glu435, Leu437, Glu444, and Phe580.

In some embodiments, the active site of PRMT5 comprises the amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In addition, it should be appreciated that cofactors such as SAM or SAM analogs (e.g., SAH) may also be present in the active site of PRMT5. The numbering of the PRMT5 amino acids as provided herein relates to human PRMT5 isoform A (SEQ ID NO:1) depicted (in part) in Table A. However, it should be appreciated that the interactions between the compounds of formula Ring AA-M-Ring BB provided herein and the active site of PRMT5 should be applicable to homologous versions of PRMT5, just as long as the active site is conserved. The term “active site” (or “binding pocket”) relates to the three-dimensional structure of the portion of the protein responsible for the methyltransferase activity, e.g., the region of the protein that acts on the substrate(s) of the protein or catalyze the transfer of a methyl group from SAM to a protein substrate.

In some embodiments, the active site of PRMT5 comprises the amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In some embodiments, the Ring AA-M-Ring BB compounds described herein interact with glutamic acid residues Glu435 and Glu444. In certain embodiments, the Ring BB portion of the compound interacts with Glu435 and Glu444. In some embodiments, the linker M interacts with Glu435 and Glu444. In certain embodiments, the Ring BB portion of the compound and the linker interact with Glu435 and Glu444. In some embodiments, the interaction of the compounds with glutamic acid residues Glu435 and Glu444 is in addition to the pi-cation interaction with SAM and the pi-stacking interaction with Phe327. In some embodiments, the interaction of the compound with Glu435 and Glu444 is a hydrogen bonding interaction. In some embodiments, the interaction of the compound with Glu435 and Glu444 is mediated through a water molecule. In some embodiments, the Ring BB of the compounds provided herein comprises a heteroatom such as a nitrogen atom. In some embodiments, the nitrogen atom is tetrahedrally coordinated. In some embodiments, the nitrogen atom of Ring BB interacts with the Glu435 and Glu444, either directly or through a coordinated water molecule (See e.g., FIG. 3).

In some embodiments, compounds of the formula Ring AA-M-Ring BB described herein interact with Leu437. In some embodiments, the Ring AA-M-Ring BB compounds described herein interact with the carbonyl group of Leu437. In some embodiments, the Ring BB of the compounds provided herein comprises a heteroatom such as a nitrogen atom. In some embodiments, the nitrogen atom of Ring BB is tetrahedrally coordinated. In some embodiments, the nitrogen interacts with the carbonyl group of Leu437, either directly or through a coordinated water molecule. In some embodiments, the nitrogen interacts with the Leu437, Glu435 and Glu444, either directly or through a coordinated water molecule. In some embodiments, the linker M interacts with Leu437.

In some embodiments, the active site of PRMT5 comprises SAM and the amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In some embodiments, compounds of the formula Ring AA-M-Ring BB described herein interact with Leu319. In some embodiments Ring BB interacts with Leu319. In some embodiments, the interaction with Leu319 is in addition to the interaction with one or more of the interactions of the compound with SAM and amino acids Phe327, Glu435, Leu437 and Glu444.

In some embodiments, compounds of the formula Ring AA-M-Ring BB described herein interact with Phe580. In some embodiments, Ring AA of the compound interacts with Phe580. In some embodiments, the interaction with Phe580 is in addition to the interaction with one or more of the interactions of the compound with SAM and amino acids Leu319, Phe327, Glu435, Leu437 and Glu444.

In some embodiments, compounds of the formula Ring AA-M-Ring BB described herein interact with SAM and Phe327 through Ring BB and with Phe580 through Ring AA. The compounds described herein can interact with SAM and Phe327 through Ring BB and with Phe580 through Ring AA at the same because the linker M allows for the planes of Ring AA and Ring BB to be at an angle between 75° and 105°. In some embodiments, the angle of the planes of Ring AA and Ring BB is between 80° and 100°. In some embodiments, the angle of the planes of Ring AA and Ring BB is between 85° and 95°. In some embodiments, the angle of the planes of Ring AA and Ring BB is 70°, 71°, 72°, 73°, 74°, 75°, 76°, 77°, 78°, 79 °, 80°, 81°, 82°, 83°, 84°, 85°, 86°, 87°, 88°, 89°, 90°, 91°, 92°, 93°, 94°, 95°, 96°, 97°, 98°, 99°, 100°, 101°, 102°, 103°, 104°, 105°, 106°, 107°, 108°, 109°, or 110°.

In some embodiments the linker M is a flexible linker. In some embodiments, linker M is unbranched. In some embodiments, linker M is flexible enough to allow Ring BB of the compound to get sufficiently close to SAM to engage in a pi-cation interaction.

In some embodiments, the disclosure provides a compound of the formula Ring AA-M-Ring BB wherein the planes of Ring AA and Ring BB are at an angle of between 75° and 105° when the compound is bound to PRMT5. In some embodiments, the angle of the planes of Ring AA and Ring BB is between 80° and 100° when the compound is bound to PRMT5. In some embodiments, the angle of the planes of Ring AA and Ring BB is between 85° and 95° when the compound is bound to PRMT5. In some embodiments, the disclosure provides a compound of the formula Ring AA-M-Ring BB wherein the planes of Ring AA and Ring BB are at an angle of between 75° and 105° when the compound is co-crystallized with PRMT5. In some embodiments, the angle of the planes of Ring AA and Ring BB is between 80° and 100° when the compound is co-crystallized with PRMT5. In some embodiments, the angle of the planes of Ring AA and Ring BB is between 85° and 95° when the compound is co-crystallized with PRMT5.

In some embodiments, the active site of PRMT5 is identified by amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580. In some embodiments, the active site of PRMT5 further includes SAM or a SAM analog. In some embodiments, compounds of the formula Ring AA-M-Ring BB described herein interact with SAM, Phe327, and one or more additional amino acids selected from the group consisting of amino acids Leu319, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580.

In some embodiments, the active site of PRMT5 is identified by amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581. In some embodiments, the active site of PRMT5 further includes SAM or a SAM analog. In some embodiments, compounds of formula Ring AA-M-Ring BB described herein interact with SAM, Phe327, and one or more additional amino acids selected from the group consisting of amino acids Leu312, Leu319, Thr323, Tyr324, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581.

As disclosed herein, compounds of formula Ring AA-M-Ring BB described herein inhibit the enzymatic activity of PRMT5 (i.e., have a low IC₅₀ value). It is believed that the low IC₅₀ is due to the well-defined interactions within the active site the compounds can engage in. Thus, it is believed that the Ring AA-M-Ring BB compounds described herein have a low IC₅₀ because they can engage in a stabilizing pi-cation interaction with SAM and pi-stacking interaction with Phe327. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 10 μM. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 1 μM. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 0.1 μM. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 50 nM. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 10 nM. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 1 nM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 10 μM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 1 μM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 0.1 μM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 50 nM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 10 nM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 1 nM. In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 10 μM. In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 1 μM. In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 0.1 μM. In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 20 nM. In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 10 nM. In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 1 nM. In certain embodiments, the IC₅₀ and EC₅₀ values are calculated according to the methods provided in the Examples herein.

In one aspect, the disclosure provides PRMT5 inhibitors with the shape of the PRMT5-active site. In some embodiments, the PRMT5 active site is defined by amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580. In some embodiments, the PRMT5 active site is defined by and amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580. In some embodiments, the PRMT5 active site is defined by and amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581. It should be appreciated that the active site may also include a SAM or an analog of SAM. Thus, for instance, the active site may include SAH (S-adenosyl-L-homocysteine). The active site may also include sinefungin (another SAM analog). Additional SAM analogs are known in the art and are described for instance in Peterli-Roth et al. (J. Org. Chem 1994: 59, 4186-4193).

In some embodiments, the active site is defined by S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according to the atomic coordinates in Table A provided herein. Table A provides the coordinates of an exemplary crystal structure of the complex PRMT5-SAM-compound 6A. In addition, FIG. 3 provides a representation of the active site, including SAM, and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, based on the coordinates provided in Table A. FIGS. 2 and 4-6 provide additional examples of representations of compounds of formula Ring AA-M-Ring BB as described herein based on the coordinates of co-crystals of these compounds with PRMT5 (Compound FIG. 2, Compound FIG. 4, Compound FIG. 5, Compound FIG. 6, depicted below). As can be seen in the Figures all active sites have a similar geometry. It is also evident from the figures that the five exemplary compounds of formula Ring AA-M-Ring BB all show similar binding motifs. Thus, the compounds are characterized by a pi-cation interaction between Ring BB and SAM (or sinefungin or other SAM analog) and a pi-stacking interaction with Phe327. In addition, all compounds show the geometry of having planes of Rings A and B that are between 75° and 105° relative to each other. The compounds also show the interaction of the nitrogen of Ring AA with Glu435, Leu437, and Glu444, the interaction of the compounds with Leu319 and the interaction of Ring AA with Phe580.

In one aspect, the disclosure provides compositions comprising PRMT5 and a compound of the formula Ring AA-M-Ring BB as described herein. In some embodiments, the disclosure provides a composition comprising PRMT5 and a compound of the formula:

Ring AA-M-Ring BB;

wherein

Ring AA is an optionally substituted aromatic moiety;

M is an aliphatic linker; and

Ring BB is an aromatic moiety capable of undergoing a pi-cation interaction with SAM of the PRMT5-SAM complex and capable of undergoing a pi-stacking interaction with Phe327 of PRMT5;

wherein the planes of Ring A and Ring B are at an angle between 75° and 105° relative to each other. In some embodiments, the compound has an IC₅₀ for PRMT5 of less than 100 nM. In some embodiments, the compound has an IC₅₀ for PRMT5 of less than 50 nM. In some embodiments, the compound has an IC₅₀ for PRMT5 of less than 10 nM. In some embodiments, the compound has an IC₅₀ for PRMT5 of less than 1 nM. In some embodiments, the compositions also includes a co-factor, such as SAM.

The composition comprising PRMT5 and the compound of the formula Ring AA-M-Ring BB may include additional components such as additional proteins, including proteins with which PRMT5 is associated intracellularly (e.g., MEP50). In some embodiments, the complex is isolated or partially isolated. An isolated form of the complex, for instance, is a complex comprising PRMT5 and a compound as the main components, optionally with buffers, salts, etc. in addition to the main components. Such complexes are formed for instance in vitro. In some embodiments, an isolated complex is a complex purified from the cell. In some embodiments, an isolated complex does not include any major cellular components except for PRMT5. However, it should be appreciated that the complexes may be administered as a complex, for instance to compete out active PRMT5 with the inactive complexed PRMT5. In some embodiments, the complex is in vivo (e.g., intracellular and/or in a subject). The complex may be formed for instance upon addition of the compound of the formula Ring AA-M-Ring to a subject or cell resulting in the formation of the complex in vivo. Because of the ability of the compounds to inhibit the enzymatic activity of PRMT5 (e.g., IC₅₀<100 nM), it is expected that the complexes provide herein will be particularly stable. The affinity of the compound for PRMT5 is typically correlated to the IC₅₀.

Crystal Structure of PRMT5

In certain embodiments, the present invention provides three-dimensional structural information for PRMT5 or for PRMT5 variants that comprise one or more amino acid substitutions, deletions, or duplications. In some embodiments, the invention provides methods for constructing models of these variants using the three-dimensional structural information for PRMT5 as a template. The method may include adjusting the backbone dihedral angles and the side chains of each amino acid that is modeled until a low energy conformation is obtained. (e.g., by using AMoRe, Phaser, MolRep or other crystallography software programs)

In certain embodiments, X-ray diffraction data collection is performed in an X-ray crystallography facility. One, two, three, or more diffraction data sets may be collected from one or more PRMT5 crystals. In certain embodiments, the crystals of the present invention diffract to a resolution limit of at least approximately 8 angstrom (Å). In certain embodiments, the crystals diffract to a resolution limit of at least approximately 6 Å. In certain embodiments, the crystals diffract to a resolution limit of at least approximately 4 Å. In certain embodiments, the crystals diffract to a resolution limit of at least approximately 2.5 Å. In certain embodiments, the crystal diffracts x-rays for a determination of structural coordinates to a maximum resolution of about 3.9 Å, of about 3.2 Å, or of about 2.9 Å. The crystals may diffract to a maximum resolution of about 2.5 Å to about 3.5 Å, of about 2.0 Å to about 3.0 Å, of about 2.5 Å to about 3.0 Å, or of about 3.0 Å to about 3.5 Å.

Diffraction data can be collected at variable oscillation angles, number of frames and exposure times that all depend on the equipment used and on the quality of the crystal(s) used to collect the data. One of ordinary skill would know how to optimize these parameters (Principles of protein X-ray crystallography by J. Drenth. 2nd ed. (1999) Springer-Verlag, Heidelberg, Germany; Structure Determination by X-ray Crystallography by M. Ladd and R. Palmer. 4th ed. (2003) Kluwer Academic/Plenum Publishers, New York, N.Y.). In certain embodiments, diffraction data can be collected with 1° oscillation. Other oscillation may be used, e.g. oscillations of less than or greater than 1°. For example, diffraction data can be collected with 0.1°, 0.3°, 0.5°, 1°, 1.5°, 2°, 3°, 4°, 5°, or 10° oscillation, or any oscillation angle in between these angles. In certain embodiments, 120 frames are collected. More or fewer than 120 frames may be collected. For example, 10, 20, 50, 100, 200, 300. 400, 500, 1000, or 5000 frames may be collected, or any number of frames in between these numbers. In certain embodiments, the exposure is 5 minutes per frame. Other frame exposure times may also be used, such as, for example 5 seconds, 10 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, 60 seconds, 120 seconds, 180 seconds, 3 minutes, 4 minutes, 10 minutes, 20 minutes, 30 minutes per frame or any exposure time in between these times. Data merging and scaling can be done, for example, using HKL2000 software suite (HKL Research, Inc., Charlottesville, Va.). Structure determination, model building, and refinement can be performed, for example, using software such as Molrep, coot and Refmac that are part of CCP4 software suite. MolRep is a program for automated molecular replacement (e.g., MolRep, version 10.2.35). Coot Graphical Interface by Paul Emsley (www.ysbl.york.ac.uk/˜emsley) for model building includes an interface to refmac5 (Gnu Public License; refmac5, e.g. version 5.5.0072 or version 5.5.0109). A macromolecular refinement program by Garib Murshudov et al. is integrated into the CCP4 program suite (www.ccp4.ac.uk, CCP4, version 6.1.3). Structural analyses may be performed using molecular viewer software PYMOL (pymol.org).

In certain embodiments, the atomic coordinates of crystalline PRMT5 are provided. In some embodiments, the coordinates are provides on a computer readable medium or in the memory of a computer.

The three-dimensional structure of the active site of PRMT5 is provided by the atomic coordinates listed in Table A.

It should be understood that while Table A provides atomic coordinates for crystalline PRMT5, the present invention also contemplates structural modifications thereof, for example, as having significant structural homology (e.g., significant structural overlap), particularly in the areas recognized as active, and thus providing the same or similar structural information as provided herewith. Significant structural homology refers to at least one of the following criteria: (i) at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% structural homology with crystalline PRMT5; or (ii) at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% structural homology with a recognized active binding site of crystalline PRMT5. In certain embodiments, significant structural homology may also refer to at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% structural homology with the primary amino acid sequence of PRMT5. Furthermore, the primary amino acid sequence of PRMT5 may be a sequence included as a segment in a larger amino acid sequence, or may be a fragment thereof. In some embodiments, a fragment of a full-length, wild-type PRMT5 protein is provided or used in an inventive method or system provided herein. In some embodiments, a PRMT5 fragment comprises a PRMT5 sequence of 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 50-75, 75-100, 100-150, 150-200, 200-250, 250-500, or more than 500 amino acids. In some embodiments, a fragment of PRMT5 does not comprise a full-length PRMT5 sequence, for example, a full-length human PRMT5 sequence. In some embodiments, a fragment of PRMT5 comprises all or at least part of the protein responsible for the enzymatic activity of full-length PRMT5.

Uses of PRMT5 Structural Information

In another aspect the invention provides methods and/or uses of PRMT5 structural information, for example, and methods for designing, identifying, and/or screening binding compounds to PRMT5 that may be useful in treating a disease. In certain embodiments, methods for designing, identifying, and/or screening binding compounds to PRMT5 (e.g. wild-type and/or mutated PRMT5) are provided. The compound may also affect aspects of intracellular trafficking of PRMT5 or aspects of enzymatic function, such as substrate recognition and/or PRMT5 catalytic activity. In certain embodiments, methods are provided for the in silico design, identification, and/or screening of PRMT5 binding compounds using the three-dimensional structural information provided herein. In certain embodiments, methods are provided that can be used to identify inhibitors, reversible inhibitors, and/or activators of PRMT5 activity. In certain embodiments, methods are provided that can be used to identify binding compounds. In certain embodiments, methods are provided that can be used to identify binding compounds that modulate PRMT5 activity. In certain embodiments, methods are provided that can be used to test potential binding compounds for their ability to modulate PRMT5 activity. In certain embodiments, these methods include in silico, in vitro, and in vivo methods. In certain embodiments, methods are provided, solving the structure of PRMT5 homologs or orthologs using the three-dimensional structural information provided herein. In certain embodiments, methods are provided, solving the (partial) structure of proteins comprising structurally or functionally homologous domains using the three-dimensional structural information for PRMT5 provided herein.

In certain embodiments, the present disclosure provides PRMT5 inhibitors having molecular dimensions compatible with the shape of a PRMT5-active site as defined by the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according to Table A, wherein the compound has a biochemical IC50 for PRMT5 of less than 100 nM. In certain embodiments, the PRMT5 inhibitor is capable of undergoing a pi-cation interaction with SAM. In certain embodiments, the PRMT5 inhibitor is capable of undergoing a pi-stacking interaction with Phe327. In certain embodiments, the PRMT5 inhibitor is capable of interacting with Glu444.

Further provided herein are computer-assisted methods for identifying potential PRMT5 binding compounds, using a programmed computer comprising a processor, a data storage system, an input device, and an output device, wherein the methods include a) inputting into the programmed computer through said input device data comprising the atomic coordinates of a subset of the atoms generated from a complex of PRMT5 and a binding compound, thereby generating a criteria data set; b) comparing, using said processor, said criteria data set to a computer database of chemical structures stored in said computer data storage system; c) selecting from said database, using computer methods, chemical structures having a portion that is structurally similar to said criteria data set; and d) outputting to said output device the selected chemical structures having a portion similar to said criteria data set. The subsets of atomic coordinates used in such methods may include one or more of amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, and optionally one or more of amino acids Leu312, Thr323, Tyr324, Glu328, Lys333, Tyr334, Gly438, Ser439, Val503, Ser578, Trp579, and Pro581 as set forth in Table A.

Further provided herein are computer readable media that include the atomic coordinates of PRMT5 as set forth in Table A and may optionally further include programming for displaying a molecular model of PRMT5, programming for identifying a binding compound to PRMT5, and/or a database of structures of drug candidates. Further provided herein are computer systems that include such computer-readable media.

Further provided herein are computer systems that include a memory unit comprising atomic coordinates defining PRMT5 as set forth in Table A; and a processor in electrical communication with the memory unit; wherein the processor generates a molecular model having a three dimensional structure representative of at least a portion of PRMT5.

Further provided herein are computer systems that include a memory unit comprising atomic coordinates of amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, of PRMT5 as set forth in Table A; and a processor in electrical communication with the memory unit; wherein the processor generates a molecular model having a three dimensional structure representative of at least a portion of PRMT5. The memory unit may optionally further comprise the atomic coordinates of one or more of amino acids Leu312, Thr323, Tyr324, Glu328, Lys333, Tyr334, Gly438, Ser439, Val503, Ser578, Trp579, and Pro581 as set forth in Table A.

In certain embodiments, the present disclosure provides a computer readable medium comprising the atomic coordinates of the complex PRMT5-Compound A6 as set forth in Table A1.

In certain embodiments, the present disclosure provides compounds or pharmaceutical compositions to treat a proliferative disorder, cancer metabolic disorder, diabetes, obesity, blood disorder, hemoglobinopathies, sickle cell anemia, or β-thalessemia. In certain embodiments, the present disclosure provides compounds or pharmaceutical compositions to treat hematological cancers, lung cancer, prostate cancer, melanoma, or pancreatic cancer.

Compounds

As generally described above, provided herein are compounds useful as PRMT5 inhibitors. In some embodiments, the present disclosure provides a compound of Formula (I):

Ring AA-M-Ring BB  I

wherein:

Ring AA is an optionally substituted aryl moiety;

Ring BB is an optionally substituted aryl or heteroaryl moiety, wherein the aryl or heteroaryl moiety is capable of forming a cation-pi interaction with S-adenosyl methionine (SAM);

M is an acyclic linker moiety 3-10 atoms in length, which allows for the planes of Ring A and Ring B to be between 75° and 105° relative to each other, and includes a carbonyl group, wherein Ring A is attached directly to the carbonyl group, or to the alpha-carbon of the carbonyl group; and

wherein the compound has a biochemical IC₅₀ for PRMT5 of less than 100 nM.

In certain embodiments, Ring AA is a monocyclic or bicyclic, saturated, partially unsaturated, or aromatic ring having 0, 1, 2, 3, 4, or 5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein Ring AA is substituted with 0, 1, 2, 3, 4, or 5 R^y groups. In certain embodiments, Ring AA is a monocyclic aryl moiety. In certain embodiments, Ring AA is an optionally substituted, fused bicyclic heteroaryl moiety. In certain embodiments, Ring AA is an unsubstituted, fused bicyclic heteroaryl moiety. In certain embodiments, Ring AA is a phenyl moiety fused to a heterocyclic moiety. In certain embodiments, Ring AA is a phenyl moiety fused to a heteroaryl moiety. In certain embodiments, Ring AA is a phenyl moiety fused to a 5- or 6-membered heteroaryl moiety.

In certain embodiments, Ring AA is a phenyl moiety fused to a 5- or 6-membered heteroaryl moiety with one nitrogen. In certain embodiments, Ring AA is a phenyl moiety fused to a 5- or 6-membered heteroaryl moiety with two nitrogen.

In certain embodiments, Ring AA is of formula (Ia-1):

wherein

R^y is described herein.

In certain embodiments, Ring AA is of formula (Ia-2):

wherein:

Ring A is an optionally substituted, 5- to 14-membered, monocyclic or bicyclic, heterocyclyl or heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and

Y is O or S.

In certain embodiments, Ring AA is of formula (Ia-3):

wherein:

Y is O or S;

G is NR^2C, CR³R^4C, O or S;

R^2C is selected from the group consisting of optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —C(═S)R^A, —C(═S)N(R^B)₂, —S(═O)R^A, —SO₂R^A, and —SO₂N(R^B)₂;

R³ is selected from the group consisting of hydrogen, halo, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(═O)R^A, —NR^BC(═O)N(R^B)₂, —SC(═O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(═O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂;

each R^A is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl;

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring;

R^4C is selected from the group consisting of hydrogen, halo, or optionally substituted aliphatic;

each R^y is independently selected from the group consisting of halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, C(═NR^B)R^A, C(NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂, or two adjacent R^y groups may be taken together with their intervening atoms to form a saturated, partially unsaturated, or aromatic ring having 0-4 heteroatoms selected from nitrogen, oxygen, and sulfur;

p is 0, 1, or 2; and

m is 0, 1, 2, 3, or 4.

In certain embodiments, Ring AA is of formula (Ia-3):

wherein:

Y, N, R^y, m and p are as described herein;

R^2C is selected from the group consisting of:

In certain embodiments, Ring AA is of formula (Ia-4):

wherein:

R² is selected from the group consisting of optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —C(═S)R^A, —C(═S)N(R^B)₂, —S(═O)R^A, —SO₂R^A, and —SO₂N(R^B)₂;

each R^y is independently selected from the group consisting of halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR_BSO₂R^A, and —SO₂N(R^B)₂, or two adjacent R^y groups may be taken together with their intervening atoms to form a saturated, partially unsaturated, or aromatic ring having 0-4 heteroatoms selected from nitrogen, oxygen, and sulfur;

each R^A is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl;

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring;

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring;

m is 0, 1, 2, 3, or 4.

In certain embodiments, Ring AA is of formula (Ia-5):

wherein:

R³ is selected from the group consisting of hydrogen, halo, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(═O)R^A, —NR^BC(═O)N(R^B)₂, —SC(═O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(═O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂;

each R^y is independently selected from the group consisting of halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂, or two adjacent R^y groups may be taken together with their intervening atoms to form a saturated, partially unsaturated, or aromatic ring having 0-4 heteroatoms selected from nitrogen, oxygen, and sulfur;

each R^A is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl;

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring;

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring; and

m is 0, 1, 2, 3, or 4.

In certain embodiments, Ring AA is of formula (Ia-6):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-7):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-8):

wherein:

L₁ is a bond, —O—, —S—, —N(R)—, —C(O)—, —C(O)N(R)—, —N(R)C(O)N(R)—, —N(R)C(O)—, —N(R)C(O)O—, —OC(O)N(R)—, —SO₂—, —SO₂N(R)—, —N(R)SO₂—, —OC(O)—, —C(O)O—, or an optionally substituted, straight or branched, C_1-6 aliphatic chain wherein one, two, or three methylene units of L₁ are optionally and independently replaced by —O—, —S—, —N(R)—, —C(O)—, —C(O)N(R)—, —N(R)C(O)N(R)—, —N(R)C(O)—, —N(R)C(O)O—, —OC(O)N(R)—, —SO₂—, —SO₂N(R)—, —N(R)SO₂—, —OC(O)—, or —C(O)O—;

Cy^D is an optionally substituted, monocyclic, bicyclic or tricyclic, saturated, partially unsaturated, or aromatic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;

X₁, X₂, X₃, and X₄ are independently selected from the group consisting of N, CH, and CR^y, provided that at least one of X₂, X₃, and X₄ is not N;

each R^y is independently selected from the group consisting of halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl; optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(═O)R^A, —C(═O)OR^A, —C(═O)SR^A, —C(═O)N(R^B)₂, —OC(═O)R^A, —NR^BC(═O)R^A, —NR^BC(═O)N(R^B)₂, —SC(═O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(═O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂;

each R^A is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl; and

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring.

In certain embodiments, Ring AA is of formula (Ia-9):

wherein L_D, L₁ are as defined herein.

In certain embodiments, Ring AA is of formula (Ia-10):

wherein L_D, L₁ are as defined herein.

In certain embodiments, Ring AA is of formula (Ia-11):

wherein L_D, L₁ are as defined herein.

In certain embodiments, Ring AA is of formula (Ia-12):

wherein L_D, L₁ are as defined herein.

In certain embodiments, Ring AA is of formula (Ia-13):

wherein L_D, L₁ are as defined herein.

In certain embodiments, Ring AA is of formula (Ia-14):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-15):

wherein R¹, R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-16):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-17):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-18):

wherein R², R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-19):

wherein R², R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-20):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-21):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-22):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-22):

wherein R^y and m are described herein.

In certain embodiments, Ring AA is of formula (Ia-23):

wherein X^x is NR², O, or S; and R², R^y and m each are independently described herein.

In certain embodiments, Ring AA is selected from the group consisting of:

In certain embodiments, Ring BB is an optionally substituted, bicyclic heteroaryl moiety. In certain embodiments, Ring BB is an optionally substituted, bicyclic heteroaryl moiety with 1-4 nitrogen atoms. In certain embodiments, Ring BB is an unsubstituted bicyclic heteroaryl moiety. In certain embodiments, Ring BB is optionally substituted bihydroisoquinoline. In certain embodiments, Ring BB is optionally substituted tetrahydroisoquinoline. In certain embodiments, Ring BB is unsubstituted tetrahydroisoquinoline. In certain embodiments, Ring BB is optionally substituted isoindoline. In certain embodiments, Ring BB is unsubstituted isoindoline. In certain embodiments, Ring BB is an optionally substituted amino-aryl moiety. In certain embodiments, Ring BB is optionally substituted benzylamine. In certain embodiments, Ring BB is unsubstituted benzylamine.

In certain embodiments, Ring BB is of formula (Ib-1)

wherein: represents a single or double bond;

R^x is independently selected from the group consisting of halo, —CN, optionally substituted aliphatic, and —OR;

R′ is hydrogen or optionally substituted aliphatic; and

n is 0, 1, 2, 3, 4, 5, 6, 7, or 8.

In certain embodiments, Ring BB is of formula (Ib-2)

wherein:

R^x is independently selected from the group consisting of halo, —CN, optionally substituted aliphatic, and —OR;

R′ is hydrogen or optionally substituted aliphatic; and

n is 0, 1, 2, 3, 4, 5, 6, 7, or 8.

In certain embodiments, M is with the 4-8 atoms in length. In certain embodiments, M is a linker 4 atoms in length. In certain embodiments, M is a linker 5 atoms in length. In certain embodiments, the atoms of M are selected from the group consisting of C, N, O, and S. In certain embodiments, the atoms of M are selected from the group consisting of C, N, and O. In certain embodiments, M comprises an amide moiety. In certain embodiments, M comprises a hydroxyl moiety. In certain embodiments, M comprises a sulfonamide moiety. In certain embodiments, M comprises an ester moiety. In certain embodiments, M provides a distance between Ring A and Ring B ranging from approximately 6 Angstroms to approximately 10 Angstroms. In certain embodiments, M provides a distance between Ring A and Ring B ranging from approximately 8 Angstroms to approximately 9 Angstroms. In certain embodiments, M allows for the planes of Ring A and Ring B to be at an angle ranging from 85° to approximately 95°.

In certain embodiments, M is of formula (Ic):

wherein:

R¹ is hydrogen, R^z, or —C(O)R^z, wherein R^z is optionally substituted C_1-6 alkyl;

L is a bond, —N(R)C(O)—, —C(O)N(R)—, —N(R)C(O)N(R)—, —N(R)C(O)O—, —OC(O)N(R)—, —O—, —N(R)—, —C(R²)(R³)—, —O—CR²R³, —N(R)—CR²R³—, —O—CR²R³—O—, —N(R)—CR²R³—O, —N(R)—CR²R³—N(R)—, —O—CR²R³—N(R)—, —CR²R³—O—, —CR²R³—N(R)—, —O—CR²R³—CR⁹R¹⁰—, —N(R)—CR²R³—CR⁹R¹⁰—, —CR²R³—CR⁹R¹⁰—O—, —CR²R³—CR⁹R¹⁰—N(R)—, or —CR²R³—CR⁹R¹⁰—;

R⁵, R⁶, R⁷, and R⁸ are independently hydrogen, halo, or optionally substituted aliphatic; and

R⁹ and R¹⁰ are independently selected from the group consisting of hydrogen, halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl; optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(═O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂; or R⁹ and R¹⁰ are taken together with their intervening atoms to form an optionally substituted carbocyclic or heterocyclic ring.

In certain embodiments, M is of formula (Id):

wherein R¹, R⁵, R⁶, R⁷ and R⁸ are as described herein.

In certain embodiments, M is of formula (Ie):

wherein R¹, R⁵, R⁶, R⁷ and R⁸ are as described herein.

In certain embodiments, M is of formula (If):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-1):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-2):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-3):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-4).

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-5).

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-6).

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-7).

In certain embodiments, M is of formula (Ic-8).

In certain embodiments, M is of formula (Ic-9).

In certain embodiments, M is of formula (Ic-10):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-11):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ic-12):

wherein R¹ as described herein.

In certain embodiments, M is of formula (Ie):

wherein:

R¹ and R^AA are each independently hydrogen, R^z, or —C(O)R^z, wherein R^z is optionally substituted C_1-6 alkyl;

X_A is a bond, —O—, —N(R)—, —CR^4AR^5A—, —O—CR^4AR^5A, —N(R)—CR^4AR^5A—, —O—CR^4AR^5A—O—, —N(R)—CR^4AR^5A—O, —N(R)—CR^4AR^5A—N(R)—, —O—CR^4AR^5A—N(R)—, —CR^4AR^5A—O—, —CR^4AR^5A—N(R)—, —O—CR^4AR^5A—CR^6AR^7A—, —N(R)—CR^4AR^5A—CR^6AR^7A—, —CR^6AR^7A—CR^4AR^5A—O—, —CR^6AR^7A—CR^4AR^5A—N(R)—, or —CR^6AR^7A—CR^4AR^5A—;

R^2A and R^3A are independently selected from the group consisting of hydrogen, halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(═O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂; or R^2A and R^3A are taken together with their intervening atoms to form an optionally substituted carbocyclic or heterocyclic ring;

R^4A and R^5A are independently selected from the group consisting of hydrogen, halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(═O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂; or R^4A and R^5A are taken together with their intervening atoms to form an optionally substituted carbocyclic or heterocyclic ring;

R^6A and R^7A are independently selected from the group consisting of hydrogen, halo, —CN, —NO₂, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —OR^A, —N(R^B)₂, —SR^A, —C(═O)R^A, —C(O)OR^A, —C(O)SR^A, —C(O)N(R^B)₂, —OC(O)R^A, —NR^BC(O)R^A, —NR^BC(O)N(R^B)₂, —SC(O)R^A, —C(═NR^B)R^A, —C(═NR^B)N(R^B)₂, —NR^BC(═NR^B)R^B, —C(═S)R^A, —C(═S)N(R^B)₂, —NR^BC(═S)R^A, —S(O)R^A, —SO₂R^A, —NR^BSO₂R^A, and —SO₂N(R^B)₂; or R^6A and R^7A are taken together with their intervening atoms to form an optionally substituted carbocyclic or heterocyclic ring;

each R^A is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl;

each R^B is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two R^B groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring.

In certain embodiments, M is of formula (If):

wherein X_A, R^2A, R^3A, R^AA, R¹, R⁵, R⁶, R⁷ and R⁸ are as described herein.

In certain embodiments, M is of formula (Ig):

wherein X_A, R^2A, R^3A, R^AA, R¹, R⁵, R⁶, R⁷ and R⁸ are as described herein.

In certain embodiments, M is of formula (Ie-1):

wherein X_A, R^2A and R¹ are as described herein.

In certain embodiments, M is of formula (Ie-2):

wherein X_A, R^2A, R^3A, R^AA, and R¹ are as described herein.

In certain embodiments, M is of formula (Ie-3):

wherein X_A, R^2A, R^3A, R^AA, and R¹ are as described herein.

In certain embodiments, M is of formula (Ie-I):

wherein X_A is C, O or N, R^2A, R^3A, R^AA, and R¹ are as described herein.

In certain embodiments, M is of formula (Ie-2):

wherein X_A is C, O or N, R^2A, R^3A, R^AA, and R¹ are as described herein.

In certain embodiments, M is of formula (Ie-3):

wherein X_A is C, O or N, R^2A, R^3A, R^AA, and R¹ are as described herein.

In certain embodiments, M is of formula (Ie-1):

wherein X_A is C, O or N, R^AA and R¹ are H, R^2A, and R^3A are as described herein.

In certain embodiments, M is of formula (Ie-2):

wherein X_A is C, O or N, R^AA and R¹ are H, R^2A, and R^3A are as described herein.

In certain embodiments, M is of formula (Ie-3):

wherein X_A is C, O or N, R^AA and R¹ are H, R^2A, and R^3A are as described herein.

In certain embodiments, a provided compound is of Formula (II):

or a pharmaceutically acceptable salt thereof,wherein:

Q is —N(R)C(O)—, —C(O)N(R)—, —N(R)C(O)N(R)—, —N(R)C(O)O—, SO₂NR—, or —OC(O)N(R)—;

each R is independently hydrogen, nitrogen protecting group or optionally substituted C_1-6 aliphatic;

Ar′ is a monocyclic or bicyclic aromatic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein Ar′ is substituted with 0, 1, 2, 3, 4, or 5 R^x groups, as valency permits;

each R^x is independently selected from the group consisting of halo, —CN, optionally substituted aliphatic, —OR′, and —N(R″)₂;

R^Y is hydrogen, nitrogen protecting group or optionally substituted aliphatic;

R^z is hydrogen or hydroxyl group;

R′ and R″ are independently hydrogen, nitrogen or oxygen protecting group, optionally substituted C_1-6 aliphatic;

A, B, C, and D are independently 0, 1, or 2;

n is 0, 1, 2, 3, 4, or 5; and

the nitrogen substituted by R^Y optionally forms a ring system with the carbon linked with R^z, or forms a ring system with the phenyl group substituted by (R^x) n.

In certain embodiments, when Ring AA is of formula (Ia-1);

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are described herein.

In certain embodiments, when Ring AA is of formula (Ia-4):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are independently described herein.

In certain embodiments, when Ring AA is of formula (Ia-7):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, m, and n are described herein.

In certain embodiments, when Ring is of formula (Ia-3):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are independently described herein.

In certain embodiments, when Ring is of formula (Ia-7):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are independently described herein.

In certain embodiments, when Ring is of formula (Ia-8):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein C_y^D, L₁, X₁, X₂, X₃, X₄, R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are independently described herein.

In certain embodiments, when Ring is of formula (Ia-9):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein C_y^D, L₁, X₁, X₂, X₃, X₄, R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are independently described herein.

In certain embodiments, when Ring is of formula (Ia-10):

Ring BB is of formula (Ib-1) or formula (Ib-2):

and M is of formula (Ie) or formula (If):

wherein C_y^D, L₁, X₁, X₂, X₃, X₄, R^x, R^y, R¹, R⁵, R⁷, R⁸, R^2A, R^3A, R^AA, X_A, G, Y are independently described herein.

In certain embodiments, a provided compound is of Formula (III):

wherein Ar′, Q, R^z, R^x, A, B, C, and D are described as herein.

In certain embodiments, a provided compound is of Formula (IV):

wherein Ar′, Q, R¹, A, B, C, and D are described as herein.

In certain embodiments, a provided compound is of Formula (IV):

wherein:

Q, R¹, A, B, C, and D are described as herein;

Ar′ is selected from the group consisting of

In certain embodiments, R^Y is an optionally substituted aliphatic moiety connected to the ortho position of the phenyl group. In certain embodiments, R^z is a hydroxyl group. In certain embodiments, Q is —C(O)N(R)—.

In certain embodiments, a provided compound is a compound listed in Table A-1, or a pharmaceutically acceptable salt thereof

TABLE A-1
Exemplary Compounds
			LC-MS
Cmpd		Exact	m/z
No	Structure	mass	(M + H)
A1		340.1787	341.2
A2		338.1994	339.2
A3		352.2151	353.2
A4		485.2678	486.2
A5		354.1943	355.1
A6		391.1896	392.2
A7		358.1693	359.1
A8		365.1739	366.1
A9		354.1943	355.2
A10		358.1693	359.2
A11		365.1739	366.2
A12		370.1893	371.2
A13		383.1845	384.2
A14		418.1562	419.2
A15		354.1943	355.1
A16		358.1693	359.1
A17		365.1739	366.1
A18		339.1947	340.1
A19		354.1943	355.2
A20		370.1893	371.1
A21		397.2002	398.2
A22		370.1893	371.1
A23		394.2005	395.1
A24		346.2256	347.2
A25		368.21	369.2
A26		354.1943	355.2
A27		383.2209	384.2
A28		433.1671	434.1
A29		383.1845	384.2
A30		394.2005	395.1
A31		397.2002	398.1
A32		340.1787	341.2
A33		340.1787	341.2
A34		383.1845	384.1
A35		383.2209	384.2
A36		397.2002	398.1
A37		418.1562	419.1
A38		383.2209	384.2
A39		405.2052	406.2
A40		422.2569	423.2
A41		348.2049	349.2
A42		433.1671	434.1
A43		419.2209	420.2
A44		391.1896	392.1
A45		391.1896	392.1
A46		394.2005	395.2
A47		418.1562	419.1
A48		476.2424	477.2
A49		425.2315	426.2
A50		406.2005	407.2
A51		325.179	326.1
A52		419.1515	420.1
A53		433.1671	434.1
A54		404.2212	405.2
A55		324.1838	325.1
A56		330.2307	331.2
A57		324.1838	325.1
A58		330.2307	331.2
A59		339.1947	340.2
A60		375.1947	376.1
A61		339.1947	340.1
A62		339.1947	340.1
A63		339.1947	340.1
A64		394.2256	395.1
A65		419.1515	420.1
A66		390.1943	391.2
A67		406.2005	407.2
A68		406.2005	407.2
A69		393.2165	394.2
A70		463.2583	464.2
A71		477.274	478.3
A72		405.2052	406.2
A73		405.2052	406.1
A74		405.2052	406.1
A75		439.2471	440.2
A76		405.2052	406.2
A77		425.2315	426.2
A78		425.2315	426.2
A79		424.2474	425.2
A80		425.1951	426.2
A81		411.2158	412.1
A82		394.2005	395.2
A83		453.2264	454.2
A84		438.2631	439.3
A85		438.2631	439.3
A86		469.2577	470.2
A87		469.2577	470.2
A88		427.2471	428.1
A89		427.2471	428.2
A90		466.258	467.2
A91		395.2209	396.1
A92		392.1848	393.2
A93		439.2471	440.2
A94		490.258	491.2
A95		449.2427	450.2
A96		463.2583	464.2
A97		421.2002	422.2
A98		421.2002	422.2
A99		409.2365	410.2
A100		398.1842	399.1
A101		437.2315	438.2
A102		473.1984	474.2
A103		423.2522	424.3
A104		434.2318	435.2
A105		434.2318	435.2
A106		502.225	503.2
A107		488.2093	489.2
A108		502.225	503.2
A109		447.1828	448.1
A110		473.1984	474.1
A111		489.1934	490.1
A112		397.2002	398.2
A113		411.2158	412.2
A114		432.1719	433.1
A115		406.2005	407.1
A116		409.2365	410.2
A117		423.2522	424.2
A118		394.2005	395.2
A119		395.2209	396.1
A120		409.2365	410.2
A121		440.2424	441.2
A122		530.2199	531.2
A123		433.1671	434.1
A124		411.1794	412.2
A125		408.1798	409.2
A126		433.1671	434.1
A127		384.2161	385.1
A128		398.1954	399.1
A129		408.1798	409.1
A130		437.2678	438.3
A131		419.1515	420.1
A132		395.2209	396.2
A133		384.2161	385.2
A134		437.2678	438.3
A135		409.2365	410.3
A136		423.2522	424.2
A137		406.2005	407.1
A138		420.2161	421.1
A139		434.1624	435.1
A140		434.1624	435.1
A141		455.242	456.2
A142		447.1818	448.2
A143		384.2161	385.2
A144		427.1707	428.2
A145		356.1848	357.1
A146		407.2209	408.2
A147		398.1954	399.2
A148		398.1954	399.2
A149		489.1934	490.1
A150		395.2209	396.2
A151		409.2365	410.2
A152		355.1896	356.2

In certain embodiments, a provided compound is a compound listed in Table B-1, or a pharmaceutically acceptable salt thereof

TABLE B-1
Exemplary Compounds
Cmpd			LCMS m/z
No	Structure	Exact Mass	(M + H)
B1.		387.1947	388.2
B2.		390.2056	391.2
B3.		310.1681	311.1
B4.		310.1681	311.1
B5.		325.179	326.2
B6.		325.179	326.2
B7.		326.163	327.2
B8.		387.1947	388.2
B9.		387.1947	388.2
B10.		376.1899	377.2
B11.		326.163	327.2
B12.		387.1947	388.2
B13.		387.1947	388.2
B14.		395.2209	396.2
B15.		423.2522	424.2
B16.		409.2365	410.2
B17.		311.1634	312.1
B18.		311.1634	312.2
B19.		387.1947	388.2
B20.		387.1947	388.2
B21.		389.1409	390.1
B22.		353.1739	354.1
B23.		367.1896	368.1
B24.		403.1566	404.1
B25.		353.1739	354.2
B26.		367.1896	368.2
B27.		403.1566	404.2
B28.		397.2365	398.1
B29.		408.2525	409.2
B30.		422.2682	423.2
B31.		403.1566	404.2
B32.		389.1409	390.1
B33.		389.1409	390
B34.		393.2416	394.1
B35.		394.2369	395.2
B36.		408.2525	409.2
B37.		379.226	380.2
B38.		393.2416	394.2
B39.		383.2209	384.2
B40.		423.2522	424.2
B41.		451.2835	452.3
B42.		379.226	380.2
B43.		409.2365	410.2
B44.		409.2365	410.2
B45.		395.2209	396.2
B46.		423.2158	424.2
B47.		437.2678	438.3
B48.		410.2206	411.2
B49.		423.2522	424.1
B50.		381.2052	382.2
B51.		409.2365	410.1
B52.		437.2678	438.3
B53.		437.2678	438.3
B54.		410.2318	411.1
B55.		410.2318	411.1
B56.		439.2471	440.1
B57.		427.2271	428.2
B58.		410.2206	411.2

In certain embodiments, a provided compound is a compound listed in Table C-1, or a pharmaceutically acceptable salt thereof

TABLE C-1
Exemplary Compounds
Cmpd			LCMS m/z
No	Structure	Exact Mass	(M + H)
C1		322.1681	323.1
C2		284.1525	285.1
C3		379.226	380.2
C4		416.2212	417.2
C5		399.1714	400.1
C6		383.2009	384.2
C7		399.1714	400.1
C8		451.2583	452.3
C9		399.1714	400.1
C10		379.226	380.2
C11		383.2009	384.2
C12		450.2631	451.2
C13		360.1838	361.2
C14		360.1838	361.2
C15		379.226	380.2
C16		364.2151	365.2
C17		364.2151	365.2
C18		375.1947	376.2
C19		375.1947	376.2
C20		395.2209	396.2
C21		331.1896	332.1
C22		367.1566	368.1
C23		373.2365	374.2
C24		379.226	380.1
C25		380.2212	381.2
C26		380.2212	381.1
C27		303.1947	304.1
C28		290.163	291.1
C29		408.2525	409.3
C30		408.2525	407.2
C31		338.163	339.2
C32		401.2315	402.2

In certain embodiments, a provided compound is a compound listed in Table D-1, or a pharmaceutically acceptable salt thereof

TABLE D-1
Exemplary Compounds
Cmpd			LC-MS m/z
No	Structure	Exact mass	(M + H)
D1.		380.2464	381.2
D2.		366.2307	367.2
D3.		488.2675	489.2
D4.		394.262	395.0
D5.		396.2413	397.2
D6.		378.2056	379.1
D7.		367.226	368.1
D8.		365.2355	366.1
D9.		350.1743	351.1
D10.		373.2042	374.1
D11.		398.1397	399.1
D12.		403.2147	403.9
D13.		395.2573	395.9
D14.		380.2464	381.0
D15.		419.2209	420.2
D16.		350.163	351.0
D17.		410.2569	411.2
D18.		416.177	416.9
D19.		389.1991	390.0
D20.		389.1991	390.1
D21.		380.2464	381.1
D22.		380.2464	381.1
D23.		380.2464	381.1
D24.		394.262	395.1
D25.		366.2307	367.2
D26.		391.226	392.0
D27.		391.226	392.0
D28.		391.226	391.9
D29.		410.2569	411.1
D30.		440.2675	441.0
D31.		536.2787	537.3
D32.		394.262	395.2
D33.		394.262	395.2
D34.		536.2787	537.2
D35.		366.2307	367.1
D36.		378.2671	378.9
D37.		469.2365	469.9
D38.		469.2365	469.9
D39.		379.2624	380.3
D40.		360.1838	361.2
D41.		469.2365	469.9
D42.		469.2365	470.2
D43.		359.1885	360.1
D44.		363.1947	364.2
D45.		413.2103	414.1
D46.		396.2413	397.0
D47.		366.2307	367.2
D48.		349.179	350.1
D49.		394.262	395.1
D50.		394.262	395.2
D51.		394.262	395.2
D52.		365.2355	366.2
D53.		393.278	394.3
D54.		410.2569	411.3
D55.		451.2147	452.3
D56.		394.262	395.2
D57.		363.2198	364.3
D58.		399.1947	400.2
D59.		403.1784	404.2
D60.		413.2103	414.2
D61.		466.1926	467.2
D62.		461.1369	462.1
D63.		437.1661	438.2
D64.		423.1601	424.2
D65.		410.1994	411.2
D66.		420.2525	421.2
D67.		401.1991	402.2
D68.		395.1697	396.2
D69.		393.1496	394.1
D70.		393.174	394.2
D71.		389.1991	390.2
D72.		389.1991	390.2
D73.		389.1991	390.2
D74.		389.1991	390.2
D75.		389.1991	390.2
D76.		378.1744	379.2
D77.		377.1791	378.2
D78.		374.1994	375.2
D79.		409.2365	410.2
D80.		427.226	428.2
D81.		441.2416	442.3
D82.		519.2522	520.3
D83.		399.1947	400.2
D84.		400.1899	401.2
D85.		417.194	418.2
D86.		449.1991	450.2
D87.		427.1759	428.2
D88.		423.1601	424.1
D89.		410.1994	411.2
D90.		403.2147	404.2
D91.		393.1496	394.2
D92.		393.1496	394.2
D93.		384.1838	385.2
D94.		384.1838	385.2
D95.		375.1834	376.2
D96.		375.1834	376.2
D97.		360.1838	361.2
D98.		360.1838	361.2
D99.		423.2522	424.2
D100.		443.2209	444.2
D101.		427.226	428.2
D102.		412.2263	413.2
D103.		483.2522	484.2
D104.		475.226	476.2
D105.		489.2416	490.2
D106.		413.2103	414.2
D107.		399.1947	400.1
D108.		413.2103	414.2
D109.		415.1896	416.2
D110.		423.1601	424.2
D111.		398.1994	399.2
D112.		377.1791	378.2
D113.		374.1994	375.2
D114.		413.2103	414.2
D115.		413.2103	414.2
D116.		409.2729	410.2
D117.		413.2216	414.2
D118.		413.2216	414.2
D119.		414.2168	415.2
D120.		414.2168	415.1
D121.		414.2168	415.2
D122.		427.226	428.2
D123.		416.1558	417.2
D124.		495.1633	496.2
D125.		404.2212	405.2
D126.		472.2362	473.2
D127.		461.1369	462.1
D128.		461.1369	462.1
D129.		452.177	453.2
D130.		437.1661	438.2
D131.		437.1661	438.2
D132.		427.1759	428.2
D133.		427.1759	428.2
D134.		423.1601	424.2
D135.		417.194	418.2
D136.		418.2005	419.2
D137.		401.1991	402.2
D138.		391.1948	392.2
D139.		378.1744	379.2
D140.		361.179	362.2
D141.		414.2056	415.2
D142.		443.2209	444.2
D143.		503.2573	504.2
D144.		499.2471	500.3
D145.		404.1848	405.2
D146.		473.2315	474.3
D147.		412.2151	413.2
D148.		414.1943	415.2
D149.		458.2682	459.2
D150.		445.2617	446.3
D151.		402.2307	403.3
D152.		402.1943	403.2
D153.		391.1896	392.2
D154.		377.1791	378.2
D155.		361.179	362.2
D156.		430.1893	431.2
D157.		403.1896	404.2
D158.		393.1689	394.2
D159.		393.1689	394.2
D160.		406.2005	407.2
D161.		404.1848	405.2
D162.		406.2005	407.2
D163.		404.1848	405.1
D164.		404.1848	405.2
D165.		415.2008	416.2
D166.		400.1787	401.2
D167.		451.2147	452.3
D168.		423.1601	424.2
D169.		416.21	417.3
D170.		415.1606	416.2
D171.		402.1943	403.2
D172.		384.1838	385.2
D173.		413.2103	414.3
D174.		413.2103	414.3
D175.		352.2151	353.2
D176.		413.2103	414.3
D177.		443.2209	444.3
D178.		519.2522	520.3
D179.		441.2416	442.2
D180.		418.1893	419.2
D181.		457.2365	458.2
D182.		417.2052	418.2
D183.		406.2005	407.2
D184.		404.1848	405.2
D185.		456.2413	457.2
D186.		416.21	417.2
D187.		426.2307	427.3
D188.		400.1787	401.2
D189.		414.2056	415.2
D190.		378.1744	379.2
D191.		415.2008	416.2
D192.		427.226	428.2
D193.		485.2315	486.3
D194.		480.2525	481.3
D195.		406.2005	407.2
D196.		407.1845	408.2
D197.		420.2161	421.3
D198.		407.1845	408.3
D199.		413.2216	414.2
D200.		477.1319	478.2
D201.		435.221	436.2
D202.		470.2318	471.2
D203.		420.2161	421.2
D204.		417.2052	418.2
D205.		414.2168	415.2
D206.		471.227	472.2
D207.		414.2168	415.2
D208.		454.2369	455.2
D209.		468.2525	469.3
D210.		414.2056	415.2
D211.		441.2416	442.2
D212.		427.226	428.2
D213.		427.226	428.2
D214.		447.1714	448.2
D215.		447.1714	448.1
D216.		418.2369	419.2
D217.		413.2216	414.2
D218.		468.2525	469.3
D219.		482.2682	483.2
D220.		482.2682	483.3
D221.		496.2838	497.3
D222.		527.2533	528.2
D223.		399.1947	400.1
D224.		414.2168	415.2
D225.		427.1896	428.2
D226.		413.2216	414.2
D227.		412.2263	413.2
D228.		524.2787	525.3
D229.		454.2481	455.2
D230.		468.2638	469.2
D231.		511.2583	512.2
D232.		525.274	526.2
D233.		511.2696	512.2
D234.		527.2645	528.2
D235.		398.2107	399.2
D236.		413.2216	414.2
D237.		413.2216	414.2
D238.		414.2168	415.2
D239.		414.2168	415.2
D240.		468.2638	469.2
D241.		482.2794	483.3
D242.		524.29	525.4
D243.		525.274	526.2
D244.		540.2849	541.2
D245.		471.2383	472.2
D246.		525.2852	526.2
D247.		540.2961	541.2
D248.		414.2056	415.2
D249.		524.2787	525.3
D250.		482.2794	483.3
D251.		483.2634	484.3
D252.		496.2951	497.3
D253.		483.2634	484.3
D254.		455.2434	456.2
D255.		483.2747	484.3
D256.		525.2852	526.3
D257.		410.1994	411.1
D258.		410.1994	411.1
D259.		406.2005	407.2
D260.		406.2005	407.2
D261.		413.2216	414.2
D262.		470.2318	471.3
D263.		510.2631	511.3
D264.		526.258	527.3
D265.		455.2321	456.2
D266.		413.2103	414.2
D267.		403.1896	404.2
D268.		403.1896	404.2
D269.		455.2209	456.2
D270.		539.2896	540.4
D271.		402.2168	403.2
D272.		402.2168	403.2
D273.		454.2369	455.2
D274.		392.1848	393.2
D275.		413.2216	414.3
D276.		413.2216	414.3
D277.		449.1915	450.1
D278.		331.1339	332.1
D279.		377.1991	378.0
D280.		365.0949	366.0
D281.		365.0949	366.0
D282.		298.1681	299.1
D283.		298.1681	299.1
D284.		298.1681	299.1
D285.		327.1471	327.9
D286.		382.262	383.2
D287.		376.2362	377.2
D288.		327.1834	328.0
D289.		318.2307	319.1
D290.		362.2206	363.1
D291.		390.2519	390.9
D292.		390.2519	391.2
D293.		304.2151	305.1
D294.		303.2198	304.2
D295.		315.1947	316.0
D296.		277.1678	278.1
D297.		290.1994	291.1
D298.		290.1994	291.1
D299.		312.1838	313.0
D300.		355.1784	356.1
D301.		323.1885	324.0
D302.		275.1885	276.1
D303.		261.1729	262.1
D304.		305.1991	306.1
D305.		291.1834	292.1
D306.		276.1838	277.1
D307.		290.1994	291.1
D308.		297.1729	297.9
D309.		303.2198	304.1
D310.		291.1834	292.1

In certain embodiments, a provided compound is a compound listed in Table E-1, or a pharmaceutically acceptable salt thereof

TABLE E-1
Exemplary Compounds
Cmpd			LC-MS m/z
No	Structure	Exact mass	(M + H)
E1.		391.1896	392.1
E2.		311.1634	312.2
E3.		391.1896	392.1
E4.		377.1739	378.1
E5.		391.1896	392.1
E6.		391.1896	392.1
E7.		392.1848	393.2
E8.		395.2209	396.2
E9.		399.1947	400.2
E10.		397.2002	398.2
E11.		411.2158	412.2
E12.		404.1406	405.2
E13.		373.179	374.2
E14.		399.1947	400.2
E15.		433.1671	434.1
E16.		377.1739	378.1
E17.		399.1947	400.2
E18.		505.2365	506.2
E19.		377.1739	378.1
E20.		366.2307	367.2

In certain embodiments, a provided compound inhibits PRMT5. In certain embodiments, a provided compound inhibits wild-type PRMT5. In certain embodiments, a provided compound inhibits a mutant PRMT5. In certain embodiments, a provided compound inhibits PRMT5, e.g., as measured in an assay described herein. In certain embodiments, the PRMT5 is from a human. In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 10 In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 1 In certain embodiments, a provided compound inhibits PRMT5 at an IC₅₀ less than or equal to 0.1 In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 10 μM. In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 1 In certain embodiments, a provided compound inhibits PRMT5 in a cell at an EC₅₀ less than or equal to 0.1 In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 10 In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 1 In certain embodiments, a provided compound inhibits cell proliferation at an EC₅₀ less than or equal to 0.1 In some embodiments, a provided compound is selective for PRMT5 over other methyltransferases. In certain embodiments, a provided compound is at least about 10-fold selective, at least about 20-fold selective, at least about 30-fold selective, at least about 40-fold selective, at least about 50-fold selective, at least about 60-fold selective, at least about 70-fold selective, at least about 80-fold selective, at least about 90-fold selective, or at least about 100-fold selective for PRMT5 relative to one or more other methyltransferases.

It will be understood by one of ordinary skill in the art that the PRMT5 can be wild-type PRMT5, or any mutant or variant of PRMT5.

In certain embodiments, the PRMT5 is isoform A (GenBank accession no. NP006100) (SEQ ID NO.:1):

MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF
LCMPVFHPRF KREFIQEPAK NRPGPQTRSD LLLSGRDWNT
LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP
EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK
RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK
KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY
LQYLEYLSQN RPPPNAYELF AKGYEDYLQS PLQPLMDNLE
SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV
LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT
LENWQFEEWG SQVTVVSSDM REWVAPEKAD IIVSELLGSF
ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT
FSHPNRDPMI DNNRYCTLEF PVEVNTVLHG FAGYFETVLY
QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL

In certain embodiments, the PRMT5 is isoform B (GenBank accession no. NP001034708) (SEQ ID NO.:2)

MRGPNSGTEK GRLVIPEKQG FDFLCMPVFH PRFKREFIQE
PAKNRPGPQT RSDLLLSGRD WNTLIVGKLS PWIRPDSKVE
KIRRNSEAAM LQELNFGAYL GLPAFLLPLN QEDNTNLARV
LTNHIHTGHH SSMFWMRVPL VAPEDLRDDI IENAPTTHTE
EYSGEEKTWM WWHNFRTLCD YSKRIAVALE IGADLPSNHV
IDRWLGEPIK AAILPTSIFL TNKKGFPVLS KMHQRLIFRL
LKLEVQFIIT GTNHHSEKEF CSYLQYLEYL SQNRPPPNAY
ELFAKGYEDY LQSPLQPLMD NLESQTYEVF EKDPIKYSQY
QQAIYKCLLD RVPEEEKDTN VQVLMVLGAG RGPLVNASLR
AAKQADRRIK LYAVEKNPNA VVTLENWQFE EWGSQVTVVS
SDMREWVAPE KADIIVSELL GSFADNELSP ECLDGAQHFL
KDDGVSIPGE YTSFLAPISS SKLYNEVRAC REKDRDPEAQ
FEMPYVVRLH NFHQLSAPQP CFTFSHPNRD PMIDNNRYCT
LEFPVEVNTV LHGFAGYFET VLYQDITLSI RPETHSPGMF
SWFPILFPIK QPITVREGQT ICVRFWRCSN SKKVWYEWAV
TAPVCSAIHN PTGRSYTIGL

In certain embodiments, the PRMT5 is transcript variant 1 (GenBank accession no. NM_—006109).

PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATION

The present disclosure provides pharmaceutical compositions comprising a compound described herein, e.g., a compound of Formula (I), or a pharmaceutically acceptable salt thereof, as described herein, and optionally a pharmaceutically acceptable excipient. It will be understood by one of ordinary skill in the art that the compounds described herein, or salts thereof, may be present as hydrates, solvates, or polymorphs. In certain embodiments, a provided composition comprises two or more compounds described herein. In certain embodiments, a compound described herein, or a pharmaceutically acceptable salt thereof, is provided in an effective amount in the pharmaceutical composition. In certain embodiments, the effective amount is a therapeutically effective amount. In certain embodiments, the effective amount is an amount effective for inhibiting PRMT5. In certain embodiments, the effective amount is an amount effective for treating a PRMT5-mediated disorder. In certain embodiments, the effective amount is a prophylactically effective amount. In certain embodiments, the effective amount is an amount effective to prevent a PRMT5-mediated disorder.

Pharmaceutically acceptable excipients include any and all solvents, diluents, or other liquid vehicles, dispersions, suspension aids, surface active agents, isotonic agents, thickening or emulsifying agents, preservatives, solid binders, lubricants, and the like, as suited to the particular dosage form desired. General considerations in formulation and/or manufacture of pharmaceutical compositions agents can be found, for example, in Remington's Pharmaceutical Sciences, Sixteenth Edition, E. W. Martin (Mack Publishing Co., Easton, Pa., 1980), and Remington: The Science and Practice of Pharmacy, 21st Edition (Lippincott Williams & Wilkins, 2005).

Pharmaceutical compositions described herein can be prepared by any method known in the art of pharmacology. In general, such preparatory methods include the steps of bringing a compound described herein (the “active ingredient”) into association with a carrier and/or one or more other accessory ingredients, and then, if necessary and/or desirable, shaping and/or packaging the product into a desired single- or multi-dose unit.

Pharmaceutical compositions can be prepared, packaged, and/or sold in bulk, as a single unit dose, and/or as a plurality of single unit doses. As used herein, a “unit dose” is discrete amount of the pharmaceutical composition comprising a predetermined amount of the active ingredient. The amount of the active ingredient is generally equal to the dosage of the active ingredient which would be administered to a subject and/or a convenient fraction of such a dosage such as, for example, one-half or one-third of such a dosage.

Relative amounts of the active ingredient, the pharmaceutically acceptable excipient, and/or any additional ingredients in a pharmaceutical composition of the present disclosure will vary, depending upon the identity, size, and/or condition of the subject treated and further depending upon the route by which the composition is to be administered. By way of example, the composition may comprise between 0.1% and 100% (w/w) active ingredient.

Pharmaceutically acceptable excipients used in the manufacture of provided pharmaceutical compositions include inert diluents, dispersing and/or granulating agents, surface active agents and/or emulsifiers, disintegrating agents, binding agents, preservatives, buffering agents, lubricating agents, and/or oils. Excipients such as cocoa butter and suppository waxes, coloring agents, coating agents, sweetening, flavoring, and perfuming agents may also be present in the composition.

Exemplary diluents include calcium carbonate, sodium carbonate, calcium phosphate, dicalcium phosphate, calcium sulfate, calcium hydrogen phosphate, sodium phosphate lactose, sucrose, cellulose, microcrystalline cellulose, kaolin, mannitol, sorbitol, inositol, sodium chloride, dry starch, cornstarch, powdered sugar, and mixtures thereof.

Exemplary granulating and/or dispersing agents include potato starch, corn starch, tapioca starch, sodium starch glycolate, clays, alginic acid, guar gum, citrus pulp, agar, bentonite, cellulose and wood products, natural sponge, cation-exchange resins, calcium carbonate, silicates, sodium carbonate, cross-linked poly(vinyl-pyrrolidone) (crospovidone), sodium carboxymethyl starch (sodium starch glycolate), carboxymethyl cellulose, cross-linked sodium carboxymethyl cellulose (croscarmellose), methylcellulose, pregelatinized starch (starch 1500), microcrystalline starch, water insoluble starch, calcium carboxymethyl cellulose, magnesium aluminum silicate (Veegum), sodium lauryl sulfate, quaternary ammonium compounds, and mixtures thereof.

Exemplary surface active agents and/or emulsifiers include natural emulsifiers (e.g., acacia, agar, alginic acid, sodium alginate, tragacanth, chondrux, cholesterol, xanthan, pectin, gelatin, egg yolk, casein, wool fat, cholesterol, wax, and lecithin), colloidal clays (e.g., bentonite (aluminum silicate) and Veegum (magnesium aluminum silicate)), long chain amino acid derivatives, high molecular weight alcohols (e.g., stearyl alcohol, cetyl alcohol, oleyl alcohol, triacetin monostearate, ethylene glycol distearate, glyceryl monostearate, and propylene glycol monostearate, polyvinyl alcohol), carbomers (e.g., carboxy polymethylene, polyacrylic acid, acrylic acid polymer, and carboxyvinyl polymer), carrageenan, cellulosic derivatives (e.g., carboxymethylcellulose sodium, powdered cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose), sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monolaurate (Tween 20), polyoxyethylene sorbitan (Tween 60), polyoxyethylene sorbitan monooleate (Tween 80), sorbitan monopalmitate (Span 40), sorbitan monostearate (Span 60], sorbitan tristearate (Span 65), glyceryl monooleate, sorbitan monooleate (Span 80)), polyoxyethylene esters (e.g., polyoxyethylene monostearate (Myrj 45), polyoxyethylene hydrogenated castor oil, polyethoxylated castor oil, polyoxymethylene stearate, and Solutol), sucrose fatty acid esters, polyethylene glycol fatty acid esters (e.g., Cremophor™), polyoxyethylene ethers, (e.g., polyoxyethylene lauryl ether (Brij 30)), poly(vinyl-pyrrolidone), diethylene glycol monolaurate, triethanolamine oleate, sodium oleate, potassium oleate, ethyl oleate, oleic acid, ethyl laurate, sodium lauryl sulfate, Pluronic F68, Poloxamer 188, cetrimonium bromide, cetylpyridinium chloride, benzalkonium chloride, docusate sodium, and/or mixtures thereof

Exemplary binding agents include starch (e.g., cornstarch and starch paste), gelatin, sugars (e.g., sucrose, glucose, dextrose, dextrin, molasses, lactose, lactitol, mannitol, etc.), natural and synthetic gums (e.g., acacia, sodium alginate, extract of Irish moss, panwar gum, ghatti gum, mucilage of isapol husks, carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, cellulose acetate, poly(vinyl-pyrrolidone), magnesium aluminum silicate (Veegum), and larch arabogalactan), alginates, polyethylene oxide, polyethylene glycol, inorganic calcium salts, silicic acid, polymethacrylates, waxes, water, alcohol, and/or mixtures thereof.

Exemplary preservatives include antioxidants, chelating agents, antimicrobial preservatives, antifungal preservatives, alcohol preservatives, acidic preservatives, and other preservatives.

Exemplary antioxidants include alpha tocopherol, ascorbic acid, acorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, monothioglycerol, potassium metabisulfite, propionic acid, propyl gallate, sodium ascorbate, sodium bisulfite, sodium metabisulfite, and sodium sulfite.

Exemplary chelating agents include ethylenediaminetetraacetic acid (EDTA) and salts and hydrates thereof (e.g., sodium edetate, disodium edetate, trisodium edetate, calcium disodium edetate, dipotassium edetate, and the like), citric acid and salts and hydrates thereof (e.g., citric acid monohydrate), fumaric acid and salts and hydrates thereof, malic acid and salts and hydrates thereof, phosphoric acid and salts and hydrates thereof, and tartaric acid and salts and hydrates thereof. Exemplary antimicrobial preservatives include benzalkonium chloride, benzethonium chloride, benzyl alcohol, bronopol, cetrimide, cetylpyridinium chloride, chlorhexidine, chlorobutanol, chlorocresol, chloroxylenol, cresol, ethyl alcohol, glycerin, hexetidine, imidurea, phenol, phenoxyethanol, phenylethyl alcohol, phenylmercuric nitrate, propylene glycol, and thimerosal.

Exemplary antifungal preservatives include butyl paraben, methyl paraben, ethyl paraben, propyl paraben, benzoic acid, hydroxybenzoic acid, potassium benzoate, potassium sorbate, sodium benzoate, sodium propionate, and sorbic acid.

Exemplary alcohol preservatives include ethanol, polyethylene glycol, phenol, phenolic compounds, bisphenol, chlorobutanol, hydroxybenzoate, and phenylethyl alcohol. Exemplary acidic preservatives include vitamin A, vitamin C, vitamin E, beta-carotene, citric acid, acetic acid, dehydroacetic acid, ascorbic acid, sorbic acid, and phytic acid.

Other preservatives include tocopherol, tocopherol acetate, deteroxime mesylate, cetrimide, butylated hydroxyanisol (BHA), butylated hydroxytoluened (BHT), ethylenediamine, sodium lauryl sulfate (SLS), sodium lauryl ether sulfate (SLES), sodium bisulfite, sodium metabisulfite, potassium sulfite, potassium metabisulfite, Glydant Plus, Phenonip, methylparaben, Germall 115, Germaben II, Neolone, Kathon, and Euxyl. In certain embodiments, the preservative is an anti-oxidant. In other embodiments, the preservative is a chelating agent.

Exemplary buffering agents include citrate buffer solutions, acetate buffer solutions, phosphate buffer solutions, ammonium chloride, calcium carbonate, calcium chloride, calcium citrate, calcium glubionate, calcium gluceptate, calcium gluconate, D-gluconic acid, calcium glycerophosphate, calcium lactate, propanoic acid, calcium levulinate, pentanoic acid, dibasic calcium phosphate, phosphoric acid, tribasic calcium phosphate, calcium hydroxide phosphate, potassium acetate, potassium chloride, potassium gluconate, potassium mixtures, dibasic potassium phosphate, monobasic potassium phosphate, potassium phosphate mixtures, sodium acetate, sodium bicarbonate, sodium chloride, sodium citrate, sodium lactate, dibasic sodium phosphate, monobasic sodium phosphate, sodium phosphate mixtures, tromethamine, magnesium hydroxide, aluminum hydroxide, alginic acid, pyrogen-free water, isotonic saline, Ringer's solution, ethyl alcohol, and mixtures thereof.

Exemplary lubricating agents include magnesium stearate, calcium stearate, stearic acid, silica, talc, malt, glyceryl behanate, hydrogenated vegetable oils, polyethylene glycol, sodium benzoate, sodium acetate, sodium chloride, leucine, magnesium lauryl sulfate, sodium lauryl sulfate, and mixtures thereof.

Exemplary natural oils include almond, apricot kernel, avocado, babassu, bergamot, black current seed, borage, cade, camomile, canola, caraway, carnauba, castor, cinnamon, cocoa butter, coconut, cod liver, coffee, corn, cotton seed, emu, eucalyptus, evening primrose, fish, flaxseed, geraniol, gourd, grape seed, hazel nut, hyssop, isopropyl myristate, jojoba, kukui nut, lavandin, lavender, lemon, litsea cubeba, macademia nut, mallow, mango seed, meadowfoam seed, mink, nutmeg, olive, orange, orange roughy, palm, palm kernel, peach kernel, peanut, poppy seed, pumpkin seed, rapeseed, rice bran, rosemary, safflower, sandalwood, sasquana, savoury, sea buckthorn, sesame, shea butter, silicone, soybean, sunflower, tea tree, thistle, tsubaki, vetiver, walnut, and wheat germ oils. Exemplary synthetic oils include, but are not limited to, butyl stearate, caprylic triglyceride, capric triglyceride, cyclomethicone, diethyl sebacate, dimethicone 360, isopropyl myristate, mineral oil, octyldodecanol, oleyl alcohol, silicone oil, and mixtures thereof

Liquid dosage forms for oral and parenteral administration include pharmaceutically acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs. In addition to the active ingredients, the liquid dosage forms may comprise inert diluents commonly used in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylene glycol, dimethylformamide, oils (e.g., cottonseed, groundnut, corn, germ, olive, castor, and sesame oils), glycerol, tetrahydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof. Besides inert diluents, the oral compositions can include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents. In certain embodiments for parenteral administration, the compounds described herein are mixed with solubilizing agents such as Cremophor™, alcohols, oils, modified oils, glycols, polysorbates, cyclodextrins, polymers, and mixtures thereof.

Injectable preparations, for example, sterile injecTable Aqueous or oleaginous suspensions can be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation can be a sterile injectable solution, suspension or emulsion in a nontoxic parenterally acceptable diluent or solvent, for example, as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that can be employed are water, Ringer's solution, U.S.P. and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil can be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid are used in the preparation of injectables.

The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium prior to use.

In order to prolong the effect of a drug, it is often desirable to slow the absorption of the drug from subcutaneous or intramuscular injection. This can be accomplished by the use of a liquid suspension of crystalline or amorphous material with poor water solubility. The rate of absorption of the drug then depends upon its rate of dissolution which, in turn, may depend upon crystal size and crystalline form. Alternatively, delayed absorption of a parenterally administered drug form is accomplished by dissolving or suspending the drug in an oil vehicle.

Compositions for rectal or vaginal administration are typically suppositories which can be prepared by mixing the compounds described herein with suitable non-irritating excipients or carriers such as cocoa butter, polyethylene glycol or a suppository wax which are solid at ambient temperature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active ingredient.

Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active ingredient is mixed with at least one inert, pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol, and silicic acid, b) binders such as, for example, carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidinone, sucrose, and acacia, c) humectants such as glycerol, d) disintegrating agents such as agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate, e) solution retarding agents such as paraffin, f) absorption accelerators such as quaternary ammonium compounds, g) wetting agents such as, for example, cetyl alcohol and glycerol monostearate, h) absorbents such as kaolin and bentonite clay, and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may comprise buffering agents.

Solid compositions of a similar type can be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight polyethylene glycols and the like. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other coatings well known in the pharmaceutical formulating art. They may optionally comprise opacifying agents and can be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of embedding compositions which can be used include polymeric substances and waxes. Solid compositions of a similar type can be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight polyethylene glycols and the like.

The active ingredient can be in micro-encapsulated form with one or more excipients as noted above. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings, release controlling coatings and other coatings well known in the pharmaceutical formulating art. In such solid dosage forms the active ingredient can be admixed with at least one inert diluent such as sucrose, lactose, or starch. Such dosage forms may comprise, as is normal practice, additional substances other than inert diluents, e.g., tableting lubricants and other tableting aids such a magnesium stearate and microcrystalline cellulose. In the case of capsules, tablets, and pills, the dosage forms may comprise buffering agents. They may optionally comprise opacifying agents and can be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of embedding compositions which can be used include polymeric substances and waxes.

Dosage forms for topical and/or transdermal administration of a provided compound may include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, inhalants and/or patches. Generally, the active ingredient is admixed under sterile conditions with a pharmaceutically acceptable carrier and/or any desired preservatives and/or buffers as can be required. Additionally, the present disclosure encompasses the use of transdermal patches, which often have the added advantage of providing controlled delivery of an active ingredient to the body. Such dosage forms can be prepared, for example, by dissolving and/or dispensing the active ingredient in the proper medium. Alternatively or additionally, the rate can be controlled by either providing a rate controlling membrane and/or by dispersing the active ingredient in a polymer matrix and/or gel.

Suitable devices for use in delivering intradermal pharmaceutical compositions described herein include short needle devices such as those described in U.S. Pat. Nos. 4,886,499; 5,190,521; 5,328,483; 5,527,288; 4,270,537; 5,015,235; 5,141,496; and 5,417,662. Intradermal compositions can be administered by devices which limit the effective penetration length of a needle into the skin, such as those described in PCT publication WO 99/34850 and functional equivalents thereof. Jet injection devices which deliver liquid vaccines to the dermis via a liquid jet injector and/or via a needle which pierces the stratum corneum and produces a jet which reaches the dermis are suitable. Jet injection devices are described, for example, in U.S. Pat. Nos. 5,480,381; 5,599,302; 5,334,144; 5,993,412; 5,649,912; 5,569,189; 5,704,911; 5,383,851; 5,893,397; 5,466,220; 5,339,163; 5,312,335; 5,503,627; 5,064,413; 5,520,639; 4,596,556; 4,790,824; 4,941,880; 4,940,460; and PCT publications WO 97/37705 and WO 97/13537. Ballistic powder/particle delivery devices which use compressed gas to accelerate vaccine in powder form through the outer layers of the skin to the dermis are suitable. Alternatively or additionally, conventional syringes can be used in the classical mantoux method of intradermal administration.

Formulations suitable for topical administration include, but are not limited to, liquid and/or semi liquid preparations such as liniments, lotions, oil in water and/or water in oil emulsions such as creams, ointments and/or pastes, and/or solutions and/or suspensions. Topically-administrable formulations may, for example, comprise from about 1% to about 10% (w/w) active ingredient, although the concentration of the active ingredient can be as high as the solubility limit of the active ingredient in the solvent. Formulations for topical administration may further comprise one or more of the additional ingredients described herein.

A provided pharmaceutical composition can be prepared, packaged, and/or sold in a formulation suitable for pulmonary administration via the buccal cavity. Such a formulation may comprise dry particles which comprise the active ingredient and which have a diameter in the range from about 0.5 to about 7 nanometers or from about 1 to about 6 nanometers. Such compositions are conveniently in the form of dry powders for administration using a device comprising a dry powder reservoir to which a stream of propellant can be directed to disperse the powder and/or using a self propelling solvent/powder dispensing container such as a device comprising the active ingredient dissolved and/or suspended in a low-boiling propellant in a sealed container. Such powders comprise particles wherein at least 98% of the particles by weight have a diameter greater than 0.5 nanometers and at least 95% of the particles by number have a diameter less than 7 nanometers. Alternatively, at least 95% of the particles by weight have a diameter greater than 1 nanometer and at least 90% of the particles by number have a diameter less than 6 nanometers. Dry powder compositions may include a solid fine powder diluent such as sugar and are conveniently provided in a unit dose form.

Low boiling propellants generally include liquid propellants having a boiling point of below 65° F. at atmospheric pressure. Generally the propellant may constitute 50 to 99.9% (w/w) of the composition, and the active ingredient may constitute 0.1 to 20% (w/w) of the composition. The propellant may further comprise additional ingredients such as a liquid non-ionic and/or solid anionic surfactant and/or a solid diluent (which may have a particle size of the same order as particles comprising the active ingredient).

Pharmaceutical compositions formulated for pulmonary delivery may provide the active ingredient in the form of droplets of a solution and/or suspension. Such formulations can be prepared, packaged, and/or sold as aqueous and/or dilute alcoholic solutions and/or suspensions, optionally sterile, comprising the active ingredient, and may conveniently be administered using any nebulization and/or atomization device. Such formulations may further comprise one or more additional ingredients including, but not limited to, a flavoring agent such as saccharin sodium, a volatile oil, a buffering agent, a surface active agent, and/or a preservative such as methylhydroxybenzoate. The droplets provided by this route of administration may have an average diameter in the range from about 0.1 to about 200 nanometers.

Formulations described herein as being useful for pulmonary delivery are useful for intranasal delivery of a pharmaceutical composition. Another formulation suitable for intranasal administration is a coarse powder comprising the active ingredient and having an average particle from about 0.2 to 500 micrometers. Such a formulation is administered by rapid inhalation through the nasal passage from a container of the powder held close to the nares.

Formulations for nasal administration may, for example, comprise from about as little as 0.1% (w/w) and as much as 100% (w/w) of the active ingredient, and may comprise one or more of the additional ingredients described herein. A provided pharmaceutical composition can be prepared, packaged, and/or sold in a formulation for buccal administration. Such formulations may, for example, be in the form of tablets and/or lozenges made using conventional methods, and may contain, for example, 0.1 to 20% (w/w) active ingredient, the balance comprising an orally dissolvable and/or degradable composition and, optionally, one or more of the additional ingredients described herein. Alternately, formulations for buccal administration may comprise a powder and/or an aerosolized and/or atomized solution and/or suspension comprising the active ingredient. Such powdered, aerosolized, and/or aerosolized formulations, when dispersed, may have an average particle and/or droplet size in the range from about 0.1 to about 200 nanometers, and may further comprise one or more of the additional ingredients described herein.

A provided pharmaceutical composition can be prepared, packaged, and/or sold in a formulation for ophthalmic administration. Such formulations may, for example, be in the form of eye drops including, for example, a 0.1/1.0% (w/w) solution and/or suspension of the active ingredient in an aqueous or oily liquid carrier. Such drops may further comprise buffering agents, salts, and/or one or more other of the additional ingredients described herein. Other opthalmically-administrable formulations which are useful include those which comprise the active ingredient in microcrystalline form and/or in a liposomal preparation. Ear drops and/or eye drops are contemplated as being within the scope of this disclosure.

Although the descriptions of pharmaceutical compositions provided herein are principally directed to pharmaceutical compositions which are suitable for administration to humans, it will be understood by the skilled artisan that such compositions are generally suitable for administration to animals of all sorts. Modification of pharmaceutical compositions suitable for administration to humans in order to render the compositions suitable for administration to various animals is well understood, and the ordinarily skilled veterinary pharmacologist can design and/or perform such modification with ordinary experimentation.

Compounds provided herein are typically formulated in dosage unit form for ease of administration and uniformity of dosage. It will be understood, however, that the total daily usage of provided compositions will be decided by the attending physician within the scope of sound medical judgment. The specific therapeutically effective dose level for any particular subject or organism will depend upon a variety of factors including the disease, disorder, or condition being treated and the severity of the disorder; the activity of the specific active ingredient employed; the specific composition employed; the age, body weight, general health, sex and diet of the subject; the time of administration, route of administration, and rate of excretion of the specific active ingredient employed; the duration of the treatment; drugs used in combination or coincidental with the specific active ingredient employed; and like factors well known in the medical arts.

The compounds and compositions provided herein can be administered by any route, including enteral (e.g., oral), parenteral, intravenous, intramuscular, intra-arterial, intramedullary, intrathecal, subcutaneous, intraventricular, transdermal, interdermal, rectal, intravaginal, intraperitoneal, topical (as by powders, ointments, creams, and/or drops), mucosal, nasal, bucal, sublingual; by intratracheal instillation, bronchial instillation, and/or inhalation; and/or as an oral spray, nasal spray, and/or aerosol. Specifically contemplated routes are oral administration, intravenous administration (e.g., systemic intravenous injection), regional administration via blood and/or lymph supply, and/or direct administration to an affected site. In general the most appropriate route of administration will depend upon a variety of factors including the nature of the agent (e.g., its stability in the environment of the gastrointestinal tract), and/or the condition of the subject (e.g., whether the subject is able to tolerate oral administration).

The exact amount of a compound required to achieve an effective amount will vary from subject to subject, depending, for example, on species, age, and general condition of a subject, severity of the side effects or disorder, identity of the particular compound(s), mode of administration, and the like. The desired dosage can be delivered three times a day, two times a day, once a day, every other day, every third day, every week, every two weeks, every three weeks, or every four weeks. In certain embodiments, the desired dosage can be delivered using multiple administrations (e.g., two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or more administrations).

In certain embodiments, an effective amount of a compound for administration one or more times a day to a 70 kg adult human may comprise about 0.0001 mg to about 3000 mg, about 0.0001 mg to about 2000 mg, about 0.0001 mg to about 1000 mg, about 0.001 mg to about 1000 mg, about 0.01 mg to about 1000 mg, about 0.1 mg to about 1000 mg, about 1 mg to about 1000 mg, about 1 mg to about 100 mg, about 10 mg to about 1000 mg, or about 100 mg to about 1000 mg, of a compound per unit dosage form.

In certain embodiments, a compound described herein may be administered at dosage levels sufficient to deliver from about 0.001 mg/kg to about 1000 mg/kg, from about 0.01 mg/kg to about mg/kg, from about 0.1 mg/kg to about 40 mg/kg, from about 0.5 mg/kg to about 30 mg/kg, from about 0.01 mg/kg to about 10 mg/kg, from about 0.1 mg/kg to about 10 mg/kg, or from about 1 mg/kg to about 25 mg/kg, of subject body weight per day, one or more times a day, to obtain the desired therapeutic effect.

In some embodiments, a compound described herein is administered one or more times per day, for multiple days. In some embodiments, the dosing regimen is continued for days, weeks, months, or years.

It will be appreciated that dose ranges as described herein provide guidance for the administration of provided pharmaceutical compositions to an adult. The amount to be administered to, for example, a child or an adolescent can be determined by a medical practitioner or person skilled in the art and can be lower or the same as that administered to an adult.

It will be also appreciated that a compound or composition, as described herein, can be administered in combination with one or more additional therapeutically active agents. In certain embodiments, a compound or composition provided herein is administered in combination with one or more additional therapeutically active agents that improve its bioavailability, reduce and/or modify its metabolism, inhibit its excretion, and/or modify its distribution within the body. It will also be appreciated that the therapy employed may achieve a desired effect for the same disorder, and/or it may achieve different effects.

The compound or composition can be administered concurrently with, prior to, or subsequent to, one or more additional therapeutically active agents. In certain embodiments, the additional therapeutically active agent is a compound of Formula (I). In certain embodiments, the additional therapeutically active agent is not a compound of Formula (I). In general, each agent will be administered at a dose and/or on a time schedule determined for that agent. In will further be appreciated that the additional therapeutically active agent utilized in this combination can be administered together in a single composition or administered separately in different compositions. The particular combination to employ in a regimen will take into account compatibility of a provided compound with the additional therapeutically active agent and/or the desired therapeutic effect to be achieved. In general, it is expected that additional therapeutically active agents utilized in combination be utilized at levels that do not exceed the levels at which they are utilized individually. In some embodiments, the levels utilized in combination will be lower than those utilized individually.

Exemplary additional therapeutically active agents include, but are not limited to, small organic molecules such as drug compounds (e.g., compounds approved by the U.S. Food and Drug Administration as provided in the Code of Federal Regulations (CFR)), peptides, proteins, carbohydrates, monosaccharides, oligosaccharides, polysaccharides, nucleoproteins, mucoproteins, lipoproteins, synthetic polypeptides or proteins, small molecules linked to proteins, glycoproteins, steroids, nucleic acids, DNAs, RNAs, nucleotides, nucleosides, oligonucleotides, antisense oligonucleotides, lipids, hormones, vitamins, and cells.

Also encompassed by the present discosure are kits (e.g., pharmaceutical packs). The kits provided may comprise a provided pharmaceutical composition or compound and a container (e.g., a vial, ampule, bottle, syringe, and/or dispenser package, or other suitable container). In some embodiments, provided kits may optionally further include a second container comprising a pharmaceutical excipient for dilution or suspension of a provided pharmaceutical composition or compound. In some embodiments, a provided pharmaceutical composition or compound provided in the container and the second container are combined to form one unit dosage form. In some embodiments, a provided kits further includes instructions for use.

Methods of Use and Treatment

Compounds and compositions described herein are generally useful for the inhibition of PRMT5. In some embodiments, methods of treating PRMT5-mediated disorder in a subject are provided which comprise administering an effective amount of a compound described herein (e.g., a compound of Formula (I)), or a pharmaceutically acceptable salt thereof), to a subject in need of treatment. In certain embodiments, the effective amount is a therapeutically effective amount. In certain embodiments, the effective amount is a prophylactically effective amount. In certain embodiments, the subject is suffering from a PRMT5-mediated disorder. In certain embodiments, the subject is susceptible to a PRMT5-mediated disorder.

As used herein, the term “PRMT5-mediated disorder” means any disease, disorder, or other pathological condition in which PRMT5 is known to play a role. Accordingly, in some embodiments, the present disclosure relates to treating or lessening the severity of one or more diseases in which PRMT5 is known to play a role.

In some embodiments, the present disclosure provides a method of inhibiting PRMT5 comprising contacting PRMT5 with an effective amount of a compound described herein (e.g., a compound of Formula (I)), or a pharmaceutically acceptable salt thereof. The PRMT5 may be purified or crude, and may be present in a cell, tissue, or subject. Thus, such methods encompass both inhibition of in vitro and in vivo PRMT5 activity. In certain embodiments, the method is an in vitro method, e.g., such as an assay method. It will be understood by one of ordinary skill in the art that inhibition of PRMT5 does not necessarily require that all of the PRMT5 be occupied by an inhibitor at once. Exemplary levels of inhibition of PRMT5 include at least 10% inhibition, about 10% to about 25% inhibition, about 25% to about 50% inhibition, about 50% to about 75% inhibition, at least 50% inhibition, at least 75% inhibition, about 80% inhibition, about 90% inhibition, and greater than 90% inhibition.

In some embodiments, provided is a method of inhibiting PRMT5 activity in a subject in need thereof comprising administering to the subject an effective amount of a compound described herein (e.g., a compound of Formula (I)), or a pharmaceutically acceptable salt thereof.

In certain embodiments, provided is a method of altering gene expression in a cell which comprises contacting a cell with an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof. In certain embodiments, the cell in culture in vitro. In certain embodiments, the cell is in an animal, e.g., a human. In certain embodiments, the cell is in a subject in need of treatment.

In certain embodiments, provided is a method of altering transcription in a cell which comprises contacting a cell with an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof. In certain embodiments, the cell in culture in vitro. In certain embodiments, the cell is in an animal, e.g., a human. In certain embodiments, the cell is in a subject in need of treatment.

In some embodiments, a provided compound is useful in treating a proliferative disorder, such as cancer, a benign neoplasm, an autoimmune disease, or an inflammatory disease. For example, while not being bound to any particular mechanism, PRMT5 has been shown to be involved in cyclin D1 dysregulated cancers. Increased PRMT5 activity mediates key events associated with cyclin D1-dependent neoplastic growth including CUL4 repression, CDT1 overexpression, and DNA re-replication. Further, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity (Aggarwal et al., Cancer Cell. 2010 18(4):329-40). Additionally, PRMT5 has also been implicated in accelerating cell cycle progression through G1 phase and modulating regulators of G1; for example, PRMT5 may upregulate cyclin-dependent kinase (CDK) 4, CDK6, and cyclins D1, D2 and El. Moreover, PRMT5 may activate phosphoinositide 3-kinase (PI3K)/AKT signaling (Wei et al., Cancer Sci. 2012 103(9):1640-50). Thus in some embodiments, the inhibition of PRMT5 by a provided compound is useful in treating the following non-limiting list of cancers: breast cancer, esophageal cancer, bladder cancer, lung cancer, hematopoietic cancer, lymphoma, medulloblastoma, rectum adenocarcinoma, colon adenocarcinoma, gastric cancer, pancreatic cancer, liver cancer, adenoid cystic carcinoma, lung adenocarcinoma, head and neck squamous cell carcinoma, brain tumors, hepatocellular carcinoma, renal cell carcinoma, melanoma, oligodendroglioma, ovarian clear cell carcinoma, and ovarian serous cystadenocarcinoma.

In some embodiments, the inhibition of PRMT5 by a provided compound is useful in treating prostate cancer and lung cancer, in which PRMT5 has been shown to play a role (Gu et al., PLoS One 2012; 7(8):e44033; Gu et al., Biochem. J. (2012) 446 (235-241)). In some embodiments, a provided compound is useful to delay the onset of, slow the progression of, or ameliorate the symptoms of cancer. In some embodiments, a provided compound is administered in combination with other compounds, drugs, or therapeutics to treat cancer.

In some embodiments, compounds described herein are useful for treating a cancer including, but not limited to, acoustic neuroma, adenocarcinoma, adrenal gland cancer, anal cancer, angiosarcoma (e.g., lymphangiosarcoma, lymphangioendotheliosarcoma, hemangiosarcoma), appendix cancer, benign monoclonal gammopathy, biliary cancer (e.g., cholangiocarcinoma), bladder cancer, breast cancer (e.g., adenocarcinoma of the breast, papillary carcinoma of the breast, mammary cancer, medullary carcinoma of the breast), brain cancer (e.g., meningioma; glioma, e.g., astrocytoma, oligodendroglioma; medulloblastoma), bronchus cancer, carcinoid tumor, cervical cancer (e.g., cervical adenocarcinoma), choriocarcinoma, chordoma, craniopharyngioma, colorectal cancer (e.g., colon cancer, rectal cancer, colorectal adenocarcinoma), epithelial carcinoma, ependymoma, endotheliosarcoma (e.g., Kaposi's sarcoma, multiple idiopathic hemorrhagic sarcoma), endometrial cancer (e.g., uterine cancer, uterine sarcoma), esophageal cancer (e.g., adenocarcinoma of the esophagus, Barrett's adenocarinoma), Ewing sarcoma, eye cancer (e.g., intraocular melanoma, retinoblastoma), familiar hypereosinophilia, gall bladder cancer, gastric cancer (e.g., stomach adenocarcinoma), gastrointestinal stromal tumor (GIST), head and neck cancer (e.g., head and neck squamous cell carcinoma, oral cancer (e.g., oral squamous cell carcinoma (OSCC), throat cancer (e.g., laryngeal cancer, pharyngeal cancer, nasopharyngeal cancer, oropharyngeal cancer)), hematopoietic cancers (e.g., leukemia such as acute lymphocytic leukemia (ALL) (e.g., B-cell ALL, T-cell ALL), acute myelocytic leukemia (AML) (e.g., B-cell AML, T-cell AML), chronic myelocytic leukemia (CML) (e.g., B-cell CML, T-cell CML), and chronic lymphocytic leukemia (CLL) (e.g., B-cell CLL, T-cell CLL); lymphoma such as Hodgkin lymphoma (HL) (e.g., B-cell HL, T-cell HL) and non-Hodgkin lymphoma (NHL) (e.g., B-cell NHL such as diffuse large cell lymphoma (DLCL) (e.g., diffuse large B-cell lymphoma (DLBCL)), follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma (MCL), marginal zone B-cell lymphomas (e.g., mucosa-associated lymphoid tissue (MALT) lymphomas, nodal marginal zone B-cell lymphoma, splenic marginal zone B-cell lymphoma), primary mediastinal B-cell lymphoma, Burkitt lymphoma, lymphoplasmacytic lymphoma (i.e., “Waldenström's macroglobulinemia”), hairy cell leukemia (HCL), immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma and primary central nervous system (CNS) lymphoma; and T-cell NHL such as precursor T-lymphoblastic lymphoma/leukemia, peripheral T-cell lymphoma (PTCL) (e.g., cutaneous T-cell lymphoma (CTCL) (e.g., mycosis fungiodes, Sezary syndrome), angioimmunoblastic T-cell lymphoma, extranodal natural killer T-cell lymphoma, enteropathy type T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, anaplastic large cell lymphoma); a mixture of one or more leukemia/lymphoma as described above; and multiple myeloma (MM)), heavy chain disease (e.g., alpha chain disease, gamma chain disease, mu chain disease), hemangioblastoma, inflammatory myofibroblastic tumors, immunocytic amyloidosis, kidney cancer (e.g., nephroblastoma a.k.a. Wilms' tumor, renal cell carcinoma), liver cancer (e.g., hepatocellular cancer (HCC), malignant hepatoma), lung cancer (e.g., bronchogenic carcinoma, small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), adenocarcinoma of the lung), leiomyosarcoma (LMS), mastocytosis (e.g., systemic mastocytosis), myelodysplastic syndrome (MDS), mesothelioma, myeloproliferative disorder (MPD) (e.g., polycythemia Vera (PV), essential thrombocytosis (ET), agnogenic myeloid metaplasia (AMM) a.k.a. myelofibrosis (MF), chronic idiopathic myelofibrosis, chronic myelocytic leukemia (CML), chronic neutrophilic leukemia (CNL), hypereosinophilic syndrome (HES)), neuroblastoma, neurofibroma (e.g., neurofibromatosis (NF) type 1 or type 2, schwannomatosis), neuroendocrine cancer (e.g., gastroenteropancreatic neuroendoctrine tumor (GEP-NET), carcinoid tumor), osteosarcoma, ovarian cancer (e.g., cystadenocarcinoma, ovarian embryonal carcinoma, ovarian adenocarcinoma), papillary adenocarcinoma, pancreatic cancer (e.g., pancreatic andenocarcinoma, intraductal papillary mucinous neoplasm (IPMN), Islet cell tumors), penile cancer (e.g., Paget's disease of the penis and scrotum), pinealoma, primitive neuroectodermal tumor (PNT), prostate cancer (e.g., prostate adenocarcinoma), rectal cancer, rhabdomyosarcoma, salivary gland cancer, skin cancer (e.g., squamous cell carcinoma (SCC), keratoacanthoma (KA), melanoma, basal cell carcinoma (BCC)), small bowel cancer (e.g., appendix cancer), soft tissue sarcoma (e.g., malignant fibrous histiocytoma (MFH), liposarcoma, malignant peripheral nerve sheath tumor (MPNST), chondrosarcoma, fibrosarcoma, myxosarcoma), sebaceous gland carcinoma, sweat gland carcinoma, synovioma, testicular cancer (e.g., seminoma, testicular embryonal carcinoma), thyroid cancer (e.g., papillary carcinoma of the thyroid, papillary thyroid carcinoma (PTC), medullary thyroid cancer), urethral cancer, vaginal cancer and vulvar cancer (e.g., Paget's disease of the vulva).

In some embodiments, a provided compound is useful in treating a metabolic disorder, such as diabetes or obesity. For example, while not being bound to any particular mechanism, a role for PRMT5 has been recognized in adipogenesis Inhibition of PRMT5 expression in multiple cell culture models for adipogenesis prevented the activation of adipogenic genes, while overexpression of PRMT5 enhanced adipogenic gene expression and differentiation (LeBlanc et al., Mol Endocrinol. 2012 April; 26(4):583-97). Additionally, it has been shown that adipogenesis plays a pivotal role in the etiology and progression of diabetes and obesity (Camp et al., Trends Mol Med. 2002 September; 8(9):442-7). Thus in some embodiments, the inhibition of PRMT5 by a provided compound is useful in treating diabetes and/or obesity.

In some embodiments, a provided compound is useful to delay the onset of, slow the progression of, or ameliorate the symptoms of, diabetes. In some embodiments, the diabetes is Type 1 diabetes. In some embodiments, the diabetes is Type 2 diabetes. In some embodiments, a provided compound is useful to delay the onset of, slow the progression of, or ameliorate the symptoms of, obesity. In some embodiments, a provided compound could be used in combination with other compounds, drugs, or therapeutics, such as metformin and insulin, to treat diabetes and/or obesity.

In some embodiments, a provided compound is useful in treating a blood disorder, such as sickle cell disease or 3-thalassemia. For example, while not being bound to any particular mechanism, PRMT5 is a known repressor of γ-globin gene expression, and increased fetal γ-globin (HbF) levels in adulthood are associated with symptomatic amelioration in sickle cell disease and 3-thalassemia (Xu et al., Haematologica. 2012 November; 97(11):1632-40). Thus in some embodiments, the inhibition of PRMT5 by a provided compound is useful in treating a blood disorder, such as sickle cell disease or β-thalassemia.

In some embodiments, a provided compound is useful to delay the onset of, slow the progression of, or ameliorate the symptoms of, sickle cell disease. In some embodiments, a provided compound is useful to delay the onset of, slow the progression of, or ameliorate the symptoms of, β-thalassemia. In some embodiments, a provided compound could be used in combination with other compounds, drugs, or therapeutics, to treat sickle cell disease or β-thalassemia.

Synthetic Methods

In some embodiments, compounds described herein can prepared using methods shown in general Scheme A-1. Compound Bb can be prepared via ring opening of a chiral or racemic epoxide group. This amino alcohol intermediate can be coupled to form an amide via normal amide coupling methodology using a carboxylic acid Aa wherein Z is hydrogen or via amination of an ester of intermediate Aa when Z is an optionally substituted aliphatic group.

For example, exemplary Schemes A-2 and A-3 show such couplings.

In some embodiments, an amide coupling step can be used to provide a key intermediate for further synthesis, as shown, for example, in exemplary Scheme A-4.

In some embodiments, compounds described herein can prepared using methods shown in general Scheme B-1. Compound Bb can be prepared via ring opening of a chiral or racemic epoxide group. This amino alcohol intermediate can be coupled to form an amide via normal amide coupling methodology using a carboxylic acid Cc wherein Z is hydrogen or via amination of an ester of intermediate Cc when Z is an optionally substituted aliphatic group.

Analogous reactions may be performed to form a carbamate or urea bond using methods known to one of ordinary skill in the art.

In some embodiments, such couplings can be used to provide a key intermediate for further synthesis, as shown, for example, in exemplary Scheme B-2.

In other embodiments, an amide coupling step is the final synthetic step as shown in exemplary Scheme B-3.

In some embodiments, compounds described herein can prepared using methods shown in general Scheme C-1, which describes ring opening of a chiral or racemic epoxide group to form the amino alcohol moiety linker.

In some embodiments, epoxide opening can be performed in the final step as shown in exemplary Schemes C-2 and C-3.

In some embodiments, an amide coupling step can be used to provide a key intermediate for further synthesis, as shown in exemplary Schemes C-4 to C-6.

In some embodiments, compounds described herein can prepared using methods shown in general Scheme D-1, comprising a ring opening of a chiral or racemic epoxide group.

In some embodiments, the epoxide opening is the final step in the synthesis, as shown in exemplary Scheme D-2.

In some embodiments, epoxide opening is employed to build key intermediates for addition synthesis as shown in exemplary schemes D-3 to D-6.

In some embodiments, compounds described herein can prepared using methods shown in general Scheme E-1 ring opening of a chiral or racemic epoxide group to form an amino alcohol moiety. A ring opening step can be performed in either direction as shown in scheme 1.

In some embodiments, compounds described herein can prepared using methods shown in general Scheme E-2. Compound B can be prepared via ring opening of a chiral or racemic epoxide group. This amino alcohol intermediate can be coupled to form an amide via normal amide coupling methodology using a carboxylic acid A wherein Z₁ is hydrogen or via amination of an ester of intermediate A when Z₁ is an optionally substituted aliphatic group.

In some embodiments, compounds described herein can prepared using methods shown in general Scheme E-3. Compound Bc can be prepared via ring opening of a chiral or racemic epoxide group. This amino alcohol intermediate can be coupled to form an amide via normal amide coupling methodology using a carboxylic acid A wherein Z₁ is hydrogen or via amination of an ester of intermediate A when Z₁ is an optionally substituted aliphatic group

In some embodiments, compounds described herein can prepared using methods shown in general Scheme E-4, which describes ring opening of a chiral or racemic epoxide group to form the amino alcohol moiety linker.

EXAMPLES

In order that the invention described herein may be more fully understood, the following examples are set forth. It should be understood that these examples are for illustrative purposes only and are not to be construed as limiting this invention in any manner.

PRMT5-MEP50 Crystallization and Structure Determination

Crystals were grown using the coexpressed PRMT5-MEP50, stored in a buffer containing 50 mM Tris, 250 mM sodium chloride, 1 mM TCEP, pH 8.0 and concentrated to 10-30 mg/ml. The protein (typically at 15 mg/ml) was incubated with 0.5-2 mM sinefungin or SAM or SAH, and 0.5-2 mM compound (solubilized at 50-200 mM in DMSO) on ice for 20-120 minutes prior to crystallization. Crystals were grown using vapor diffusion methods with hanging drop trays. 1+1 μL or 2+2 μL drops were suspended over well solutions containing 0.05-0.5 M sodium acetate, 0.05-0.2 M sodium citrate pH 5-6, 5-15% w/v PEG 4000 (measured pH 5.7-6.5), with typical crystallization conditions being 0.2 M sodium acetate, 0.1 M sodium citrate pH 5.5, 10% w/v PEG 4000 (measured pH=6.1). Seeding techniques are used to reliably obtain crystals of protein-ligand complexes. Crystals appeared after 1-2 days and grew to full size in 5-7 days. A selection of PRMT5-MEP5-compound crystals is shown in FIG. 1. Crystals were cryoprotected into a final solution of 0.2 M sodium acetate, 0.1 M sodium citrate pH 5.5, 10% w/v PEG 4000, 20% glycerol through a series of step increases in glycerol concentration and flash frozen in liquid nitrogen prior to data collection.

Data collection was done at home x-ray sources or at synchrotron sources (ie, APS beamline 21-ID-F), with synchrotron sources being the preferred method of data acquisition. Typically, 180° of data were obtained using 0.5-1° oscillations per frame. Data reduction was done using a variety of programs, including but not limited to Xia2, HKL2000, d*TREK, XDS, MOSFLM, etc. Crystals usually belong to space group I222 with unit cell parameters a=103.6 Å, b=137.8 Å, c=178.8 Å, α=β=γ=90°; variation around these numbers is normal for individual datasets. Crystals also belonged to space group C2 with unit cell parameters a=225.7 Å, b=104.3 Å, c=138.0 Å, α=90°, β=127.5°, γ=90°. Scaling of data was done using Aimless, Scala, XSCALE, d*TREK, Scalepack, or other programs. In some cases, molecular replacement can be performed using a previously determined structure of PRMT5-MEP50-compound using AMoRe, Phaser, MolRep or other crystallography programs, or using difference Fourier methods. Once phases were determined and the ligand was placed in the active site as defined by the difference density observed, refinement of the final structure typically was done using REFMACS, but other programs such as BUSTER, CNX, PHENIX, etc can also be used.

Biological Assays

PRMT5 Biochemical Assay

General Materials.

S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), bicine, KCl, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG), and Tris(2-carboxyethyl)phosphine hydrochloride solution (TCEP) were purchased from Sigma-Aldrich at the highest level of purity possible. ³H-SAM was purchase from American Radiolabeled Chemicals with a specific activity of 80 Ci/mmol 384-well streptavidin Flashplates were purchased from PerkinElmer.

Substrates.

Peptide representative of human histone H4 residues 1-15 was synthesized with a C-terminal linker-affinity tag motif and a C-terminal amide cap by 21^st Century Biochemicals. The peptide was high high-performance liquid chromatography (HPLC) purified to greater than 95% purity and confirmed by liquid chromatography mass spectrometry (LC-MS). The sequence was Ac-SGRGKGGKGLGKGGA[K-Biot]-amide (SEQ ID NO.:3).

Molecular Biology:

Full-length human PRMT5 (NM_—006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flanking 5′ sequence encoding a FLAG tag (MDYKDDDDK) (SEQ ID NO.:4) fused directly to Ala 2 of PRMT5. Full-length human MEP50 (NM_—024102) clone was amplified from a human testis cDNA library incorporating a 5′ sequence encoding a 6-histidine tag (MHHHHHH) (SEQ ID NO.:5) fused directly to Arg 2 of MEP50. The amplified genes were sublconed into pENTR/D/TEV (Life Technologies) and subsequently transferred by Gateway™ attL×attR recombination to pDEST8 baculvirus expression vector (Life Technologies).

Protein Expression.

Recombinant baculovirus and Baculovirus-Infected Insect Cells (BIIC) were generated according to Bac-to-Bac kit instructions (Life Technologies) and Wasilko, 2006, respectively. Protein over-expression was accomplished by infecting exponentially growing Spodoptera frugiperda (SF9) cell culture at 1.2×10⁶ cell/ml with a 5000 fold dilution of BIIC stock. Infections were carried out at 27° C. for 72 hours, harvested by centrifugation, and stored at −80° C. for purification.

Protein Purification.

Expressed full-length human Flag-PRMT5/6His-MeP50 protein complex was purified from cell paste by NiNTA agarose affinity chromatography after a five hour equilibration of the resin with buffer containing 50 mM Tris-HCL, pH 8.0, 25 mM NaCl, and 1 mM TCEP at 4° C., to minimize the adsorption of tubulin impurity by the resin. Flag-PRMT5/6His-MeP50 was eluted with 300 mM Imidazole in the same buffer. The purity of recovered protein was 87%. Reference: Wasilko, D. J. and S. E. Lee: “TIPS: titerless infected-cells preservation and scale-up” Bioprocess J., 5 (2006), pp. 29-32.

Predicted Translations:

Flag-PRMT5
(SEQ ID NO.: 6)
MDYKDDDDKA AMAVGGAGGS RVSSGRDLNC VPEIADTLGA
VAKQGFDFLC MPVFHPRFKR EFIQEPAKNR PGPQTRSDLL
LSGRDWNTLI VGKLSPWIRP DSKVEKIRRN SEAAMLQELN
FGAYLGLPAF LLPLNQEDNT NLARVLTNHI HTGHHSSMFW
MRVPLVAPED LRDDIIENAP TTHTEEYSGE EKTWMWWHNF
RTLCDYSKRI AVALEIGADL PSNHVIDRWL GEPIKAAILP
TSIFLTNKKG FPVLSKMHQR LIFRLLKLEV QFIITGTNHH
SEKEFCSYLQ YLEYLSQNRP PPNAYELFAK GYEDYLQSPL
QPLMDNLESQ TYEVFEKDPI KYSQYQQAIY KCLLDRVPEE
EKDTNVQVLM VLGAGRGPLV NASLRAAKQA DRRIKLYAVE
KNPNAVVTLE NWQFEEWGSQ VTVVSSDMRE WVAPEKADII
VSELLGSFAD NELSPECLDG AQHFLKDDGV SIPGEYTSFL
APISSSKLYN EVRACREKDR DPEAQFEMPY VVRLHNFHQL
SAPQPCFTFS HPNRDPMIDN NRYCTLEFPV EVNTVLHGFA
GYFETVLYQD ITLSIRPETH SPGMFSWFPI LFPIKQPITV
REGQTICVRF WRCSNSKKVW YEWAVTAPVC SAIHNPTGRS
YTIG L
6His-MEP50
(SEQ ID NO.: 7)
MHHHHHHRKE TPPPLVPPAA REWNLPPNAP ACMERQLEAA
RYRSDGALLL GASSLSGRCW AGSLWLFKDP CAAPNEGFCS
AGVQTEAGVA DLTWVGERGI LVASDSGAVE LWELDENETL
IVSKFCKYEH DDIVSTVSVL SSGTQAVSGS KDICIKVWDL
AQQVVLSSYR AHAAQVTCVA ASPHKDSVFL SCSEDNRILL
WDTRCPKPAS QIGCSAPGYL PTSLAWHPQQ SEVFVFGDEN
GTVSLVDTKS TSCVLSSAVH SQCVTGLVFS PHSVPFLASL
SEDCSLAVLD SSLSELFRSQ AHRDFVRDAT WSPLNHSLLT
TVGWDHQVVH HVVPTEPLPA PGPASVTE

General Procedure for PRMT5/MEP50 Enzyme Assays on Peptide Substrates.

The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use. Compounds in 100% DMSO (1 ul) were spotted into a polypropylene 384-well V-bottom plates (Greiner) using a Platemate Plus outfitted with a 384-channel head (Thermo Scientific). DMSO (1 ul) was added to Columns 11, 12, 23, 24, rows A-H for the maximum signal control and 1 ul of SAH, a known product and inhibitor of PRMT5/MEP50, was added to columns 11, 12, 23, 24, rows I-P for the minimum signal control. A cocktail (40 ul) containing the PRMT5/MEP50 enzyme and the peptide was added by Multidrop Combi (Thermo-Fisher). The compounds were allowed to incubate with PRMT5/MEP50 for 30 min at 25 degrees Celsius, then a cocktail (10 ul) containing ³H-SAM was added to initiate the reaction (final volume=51 ul). The final concentrations of the components were as follows: PRMT5/MEP50 was 4 nM, ³H-SAM was 75 nM, peptide was 40 nM, SAH in the minimum signal control wells was 100 uM, and the DMSO concentration was 1%. The assays were stopped by the addition of non-radioactive SAM (10 ul) to a final concentration of 600 uM, which dilutes the ³H-SAM to a level where its incorporation into the peptide substrate is no longer detectable. 50 ul of the reaction in the 384-well polypropylene plate was then transferred to a 384-well Flashplate and the biotinylated peptides were allowed to bind to the streptavidin surface for at least 1 hour before being washed three times with 0.1% Tween20 in a Biotek ELx405 plate washer. The plates were then read in a PerkinElmer TopCount plate reader to measure the quantity of ³H-labeled peptide bound to the Flashplate surface, measured as disintegrations per minute (dpm) or alternatively, referred to as counts per minute (cpm).

% Inhibition Calculation

$\%\mathrm{inh}=100-\left(\frac{{\mathrm{dpm}}_{\mathrm{cmpd}}-{\mathrm{dpm}}_{\min }}{{\mathrm{dpm}}_{\max }-{\mathrm{dpm}}_{\min }}\right)\times 100$

where dpm=disintegrations per minute, cmpd=signal in assay well, and min and max are the respective minimum and maximum signal controls.

Four-Parameter 1050 Fit

$Y=\mathrm{Bottom}+\frac{\left(\mathrm{Top}-\mathrm{Bottom}\right)}{(1+{\left(\frac{X}{{\mathrm{IC}}_{50}}\right)}^{\mathrm{Hill}\mathrm{Coefficient}}}$

where top and bottom are the normally allowed to float, but may be fixed at 100 or 0 respectively in a 3-parameter fit. The Hill Coefficient normally allowed to float but may also be fixed at 1 in a 3-parameter fit. Y is the % inhibition and X is the compound concentration.

Z-138 Methylation Assay

Z-138 suspension cells were purchased from ATCC (American Type Culture Collection, Manassas, Va.). RPMI/Glutamax medium, penicillin-streptomycin, heat inactivated fetal bovine serum, and D-PBS were purchased from Life Technologies, Grand Island, N.Y., USA. Odyssey blocking buffer, 800CW goat anti-rabbit IgG (H+L) antibody, and Licor Odyssey infrared scanner were purchased from Licor Biosciences, Lincoln, Nebr., USA. Symmetric di-methyl arginine antibody was purchased from EMD Millipore, Billerica, Mass., USA. 16% Paraformaldehyde was purchased from Electron Microscopy Sciences, Hatfield, Pa., USA.

Z-138 suspension cells were maintained in growth medium (RPMI 1640 supplemented with 10% v/v heat inactivated fetal bovine serum and 100 units/mL penicillin-streptomycin) and cultured at 37° C. under 5% CO₂.

Cell Treatment, in Cell Western (ICW) for Detection of Symmetric Di-Methyl Arginine and DNA Content.

Z-138 cells were seeded in assay medium at a concentration of 50,000 cells per mL to a 384-well cell culture plate with 50 μL per well. Compound (100 nL) from 384 well source plates was added directly to 384 well cell plate. Plates were incubated at 37° C., 5% CO₂ for 96 hours. After four days of incubation, 40 μL of cells from incubated plates were added to poly-D-lysine coated 384 well culture plates (BD Biosciences 356697). Plates were incubated at room temperature for 30 minutes then incubated at 37° C., 5% CO₂ for 5 hours. After the incubation, 40 μL per well of 8% paraformaldehyde in PBS (16% paraformaldahyde was diluted to 8% in PBS) was added to each plate and incubated for 30 minutes. Plates were transferred to a Biotek 405 plate washer and washed 5 times with 100 μL per well of wash buffer (1×PBS with 0.1% Triton X-100 (v/v)). Next 30 μL per well of Odyssey blocking buffer were added to each plate and incubated 1 hour at room temperature. Blocking buffer was removed and 20 μL per well of primary antibody was added (symmetric di-methyl arginine diluted 1:100 in Odyssey buffer with 0.1% Tween 20 (v/v)) and plates were incubated overnight (16 hours) at 4° C. Plates were washed 5 times with 100 μL per well of wash buffer. Next 20 μL per well of secondary antibody was added (1:200 800CW goat anti-rabbit IgG (H+L) antibody, 1:1000 DRAQS (Biostatus limited) in Odyssey buffer with 0.1% Tween 20 (v/v)) and incubated for 1 hour at room temperature. The plates were washed 5 times with 100 μL per well wash buffer then 1 time with 100 μL per well of water. Plates were allowed to dry at room temperature then imaged on the Licor Odyssey machine which measures integrated intensity at 700 nm and 800 nm wavelengths. Both 700 and 800 channels were scanned.

Calculations:

First, the ratio for each well was determined by:

$\left(\frac{\mathrm{symmetric}\mathrm{di}\text{-}\mathrm{methyl}\mathrm{Arginine}800\mathrm{nm}\mathrm{value}}{\mathrm{DRAQ}5700\mathrm{nm}\mathrm{value}}\right)$

Each plate included fourteen control wells of DMSO only treatment (minimum inhibition) as well as fourteen control wells for maximum inhibition treated with 3 μM of a reference compound (Background wells). The average of the ratio values for each control type was calculated and used to determine the percent inhibition for each test well in the plate. Reference compound was serially diluted three-fold in DMSO for a total of nine test concentrations, beginning at 3 μM. Percent inhibition was determined and IC₅₀ curves were generated using triplicate wells per concentration of compound.

Percent Inhibition=100−

$\left(\left(\frac{\begin{array}{c}\left(\mathrm{Individual}\mathrm{Test}\mathrm{Sample}\mathrm{Ratio}\right)-\\ \left(\mathrm{Background}\mathrm{Avg}\mathrm{Ratio}\right)\end{array}}{\begin{array}{c}\left(\mathrm{Minimum}\mathrm{Inhibition}\mathrm{Ratio}\right)-\\ \left(\mathrm{Background}\mathrm{Average}\mathrm{Ratio}\right)\end{array}}\right)*100\right)$

Z-138 Proliferation Assay

Z-138 suspension cells were purchased from ATCC (American Type Culture Collection, Manassas, Va.). RPMI/Glutamax medium, penicillin-streptomycin, heat inactivated fetal bovine serum were purchased from Life Technologies, Grand Island, N.Y., USA. V-bottom polypropylene 384-well plates were purchased from Greiner Bio-One, Monroe, N.C., USA. Cell culture 384-well white opaque plates were purchased from Perkin Elmer, Waltham, Mass., USA. Cell-Titer Gb® was purchased from Promega Corporation, Madison, Wis., USA. SpectraMax M5 plate reader was purchased from Molecular Devices LLC, Sunnyvale, Calif., USA.

Z-138 suspension cells were maintained in growth medium (RPMI 1640 supplemented with 10% v/v heat inactivated fetal bovine serum and cultured at 37° C. under 5% CO₂. Under assay conditions, cells were incubated in assay medium (RPMI 1640 supplemented with 10% v/v heat inactivated fetal bovine serum and 100 units/mL penicillin-streptomycin) at 37° C. under 5% CO₂.

For the assessment of the effect of compounds on the proliferation of the Z-138 cell line, exponentially growing cells were plated in 384-well white opaque plates at a density of 10,000 cells/ml in a final volume of 50 μl of assay medium. A compound source plate was prepared by performing triplicate nine-point 3-fold serial dilutions in DMSO, beginning at 10 mM (final top concentration of compound in the assay was 20 μM and the DMSO was 0.2%). A 100 nL aliquot from the compound stock plate was added to its respective well in the cell plate. The 100% inhibition control consisted of cells treated with 200 nM final concentration of staurosporine and the 0% inhibition control consisted of DMSO treated cells. After addition of compounds, assay plates were incubated for 5 days at 37° C., 5% CO₂, relative humidity >90%.

Cell viability was measured by quantitation of ATP present in the cell cultures, adding 35 μl of Cell Titer Glo® reagent to the cell plates. Luminescence was read in the SpectraMax M5 microplate reader. The concentration of compound inhibiting cell viability by 50% was determined using a 4-parametric fit of the normalized dose response curves.

Results for certain compounds described herein are shown in Table A-2.

TABLE A-2
Biological Assay Results
Cmpd No	Biochemical IC50	ICW EC50	Proliferation EC50
A1	B	B	—
A2	C	—	—
A3	C	—	—
A4	A	—	—
A5	D	—	—
A6	A	A	B
A7	B	B	D
A8	B	B	D
A9	B	D	D
A10	C	—	—
A11	B	B	D
A12	B	B	D
A13	C	—	—
A14	C	—	—
A15	B	B	C
A16	B	B	D
A17	B	B	D
A18	C	C	**
A19	A	B	C
A20	A	B	C
A21	B	B	**
A22	A	B	C
A23	A	B	C
A24	B	—	—
A25	B	—	—
A26	A	B	C
A27	A	B	C
A28	A	B	C
A29	B	B	**
A30	B	B	D
A31	C	B	D
A32	B	B	D
A33	C	—	—
A34	B	B	D
A35	B	B	D
A36	B	B	**
A37	A	A	C
A38	A	A	C
A39	A	A	B
A40	A	B	C
A41	C	—	—
A42	B	B	**
A43	A	B	C
A44	B	B	D
A45	A	A	B
A46	B	B	D
A47	A	B	C
A48	A	B	D
A49	A	B	C
A50	A	A	C
A51	D	—	—
A52	C	—	—
A53	A	B	C
A54	B	B	—
A55	B	—	—
A56	C	—	—
A57	D	—	—
A58	D	—	—
A59	C	—	—
A60	B	C	—
A61	C	—	—
A62	C	—	—
A63	D	—	—
A64	A	B	C
A65	A	B	C
A66	A	B	C
A67	A	A	C
A68	A	B	**
A69	B	C	—
A70	A	B	**
A71	A	B	**
A72	C	—	—
A73	A	A	B
A74	A	B	C
A75	A	A	C
A76	A	B	C
A77	A	A	C
A78	B	B	—
A79	A	B	C
A80	A	B	D
A81	A	A	B
A82	A	A	C
A83	B	B	D
A84	A	B	C
A85	C	C	—
A86	A	B	D
A87	C	—	—
A88	A	B	D
A89	B	C	—
A90	A	B	D
A91	A	B	C
A92	A	A	C
A93	A	A	C
A94	A	B	D
A95	A	B	D
A96	A	B	D
A97	B	B	C
A98	A	A	C
A99	A	B	C
A100	A	A	C
A101	A	A	C
A102	A	A	C
A103	A	B	**
A104	B	C	**
A105	A	B	C
A106	B	B	**
A107	A	A	C
A108	A	B	D
A109	A	A	B
A110	A	A	B
A111	A	A	B
A112	B	B	**
A113	B	B	D
A114	B	C	**
A115	D	—	—
A116	C	C	**
A117	B	B	C
A118	B	C	**
A119	A	B	D
A120	B	C	**
A121	C	—	—
A122	B	C	**
A123	A	B	C
A124	C	C	**
A125	C	—	—
A126	E	—	—
A127	B	C	**
A128	E	—	—
A129	B	C	**
A130	A	B	C
A131	C	—	—
A132	C	—	—
A133	*	—	—
A134	B	C	**
A135	C	—	—
A136	C	—	—
A137	B	C	**
A138	B	C	—
A139	*	—	—
A140	C	—	—
A141	C	—	—
A142	B	B	**
A143	C	—	—
A144	*	—	—
A145	C	—	—
A146	A	B	—
A147	*	—	—
A148	*	—	—
A149	A	B	—
A150	B	—	—
A151	B	—	—
A152	C	—	—
For Table A-2, “A” indicates an IC50 or EC50 < 0.100 μM, “B” indicates an IC50 or EC50 of 0.101-1.000 μM, “C” indicates an IC50 or EC50 of 1.001-10.000 μM, “D” indicates an IC50 or EC50 of 10.001-50 μM, and “E” indicates an IC50 or EC50 > 50 μM.
“—” indicates no data shown.
“*” indicates an IC50 or EC50 > 10 μM.
“**” indicates an IC50 or EC50 > 20 μM

Results for certain compounds described herein are shown in Table B-2.

TABLE B-2
Biological Assay Results
Cmpd No	Biochemical IC50	ICW EC50	Proliferation EC50
B1.	A	A	C
B2.	A	A	C
B3.	A	A	C
B4.	C	—	—
B5.	B	B	**
B6.	C	—	—
B7.	C	—	—
B8.	A	A	C
B9.	A	A	C
B10.	A	B	C
B11.	A	C	—
B12.	B	C	**
B13.	A	A	B
B14.	A	B	C
B15.	A	B	D
B16.	A	A	B
B17.	B	B	**
B18.	B	B	D
B19.	A	B	D
B20.	A	A	B
B21.	B	B	**
B22.	B	B	**
B23.	B	B	**
B24.	A	B	C
B25.	B	C	**
B26.	B	B	D
B27.	C	—	—
B28.	A	B	D
B29.	A	B	C
B30.	A	B	C
B31.	B	B	D
B32.	B	B	**
B33.	C	—	—
B34.	A	B	D
B35.	A	B	D
B36.	A	B	D
B37.	A	B	**
B38.	A	B	D
B39.	B	C	**
B40.	A	A	C
B41.	A	A	C
B42.	B	C	**
B43.	B	B	C
B44.	A	—	B
B45.	A	B	—
B46.	C	—	—
B47.	B	B	—
B48.	B	B	—
B49.	B	—	—
B50.	B	—	—
B51.	B	—	—
B52.	B	—	—
B53.	B	—	—
B54.	A	—	—
B55.	A	—	—
B56.	B	—	—
B57.	B	—	—
B58.	A	—	—
For Table B-2, “A” indicates an IC50 or EC50 < 0.100 μM, “B” indicates an IC50 or EC50 of 0.101-1.000 μM, “C” indicates an IC50 or EC50 of 1.001-10.000 μM, “D” indicates an IC50 or EC50 of 10.001-50 μM, and “E” indicates an IC50 or EC50 > 50 μM.
“—” indicates no data.
“**” indicates an IC50 or EC50 > 20 μM.

Results for certain compounds described herein are shown in Table C-2.

TABLE C-2
Biological Assay Results
Cmpd No	Biochemical IC50	ICW EC50	Proliferation EC50
C1	B	B	**
C2	D	—	—
C3	D	—	—
C4	A	B	C
C5	A	C	—
C6	A	B	**
C7	A	B	D
C8	A	B	C
C9	B	B	D
C10	—	E	—
C11	—	E	—
C12	A	A	C
C13	—	E	—
C14	—	E	—
C15	B	B	**
C16	C	—	—
C17	C	—	—
C18	C	—	—
C19	B	B	**
C20	B	C	—
C21	C	—	—
C22	C	—	—
C23	C	—	—
C24	C	—	—
C25	C	—	—
C26	C	—	—
C27	E	—	—
C28	C	—	—
C29	B	B	D
C30	C	—	—
C31	B	B	**
C32	*	—	—
For Table C-2, “A” indicates an IC50 or EC50 < 0.100 μM, “B” indicates an IC50 or EC50 of 0.101-1.000 μM, “C” indicates an IC50 or EC50 of 1.001-10.000 μM, “D” indicates an IC50 or EC50 of 10.001-50 μM, and “E” indicates an IC50 or EC50 > 50 μM.
“—” indicates no data.
“*” indicates an IC50 or EC50 > 10 μM.
“**” indicates an IC50 or EC50 > 20 μM.

Results for certain compounds described herein are shown in Table D-2.

TABLE D-2
Biological Assay Results
Cmpd No	Biochemical IC50	ICW EC50	Proliferation EC50
D1.	B	—	D
D2.	C	—	—
D3.	B	—	—
D4.	B	—	—
D5.	B	—	—
D6.	B	—	—
D7.	D	—	—
D8.	C	—	—
D9.	C	—	**
D10.	B	—	—
D11.	B	—	—
D12.	C	—	**
D13.	C	—	—
D14.	C	—	—
D15.	C	—	—
D16.	C	—	—
D17.	B	—	—
D18.	C	—	**
D19.	C	—	—
D20.	C	—	—
D21.	C	—	E
D22.	B	—	D
D23.	C	—	D
D24.	C	—	E
D25.	C	—	D
D26.	D	—	E
D27.	C	—	E
D28.	C	—	E
D29.	D	—	D
D30.	E	—	D
D31.	B	C	D
D32.	C	**	E
D33.	C	—	E
D34.	C	—	D
D35.	C	—	—
D36.	D	—	—
D37.	C	—	—
D38.	E	—	—
D39.	B	C	**
D40.	C	—	—
D41.	C	—	—
D42.	D	—	—
D43.	B	C	**
D44.	C	—	—
D45.	A	B	C
D46.	C	—	—
D47.	A	B	C
D48.	C	—	—
D49.	B	B	C
D50.	C	—	—
D51.	E	—	—
D52.	C	—	—
D53.	B	B	D
D54.	E	—	—
D55.	C	—	—
D56.	E	—	—
D57.	C	—	—
D58.	B	C	D
D59.	B	D	D
D60.	B	B	D
D61.	E	—	—
D62.	B	C	D
D63.	B	C	D
D64.	C	—	—
D65.	A	B	D
D66.	B	—	—
D67.	B	C	D
D68.	B	D	D
D69.	C	—	—
D70.	C	—	—
D71.	C	—	—
D72.	B	C	D
D73.	C	—	—
D74.	B	C	D
D75.	B	C	D
D76.	C	—	—
D77.	C	—	—
D78.	C	—	—
D79.	D	—	—
D80.	B	**	C
D81.	B	B	D
D82.	B	C	D
D83.	B	C	D
D84.	B	C	C
D85.	B	C	D
D86.	B	C	D
D87.	C	—	—
D88.	B	C	D
D89.	B	C	D
D90.	B	C	D
D91.	C	—	—
D92.	B	C	D
D93.	B	C	D
D94.	B	C	D
D95.	B	C	D
D96.	C	—	—
D97.	C	—	—
D98.	C	—	—
D99.	D	—	—
D100.	C	—	—
D101.	C	—	—
D102.	A	B	C
D103.	B	B	C
D104.	B	C	**
D105.	A	C	D
D106.	A	C	**
D107.	B	C	**
D108.	A	C	D
D109.	B	B	D
D110.	B	**	—
D111.	B	C	—
D112.	B	**	**
D113.	B	B	D
D114.	B	**	—
D115.	C	—	—
D116.	A	C	**
D117.	B	C	**
D118.	A	B	C
D119.	B	B	C
D120.	C	—	—
D121.	B	B	**
D122.	C	—	—
D123.	B	C	D
D124.	B	D	**
D125.	B	C	D
D126.	B	C	**
D127.	B	D	**
D128.	C	—	—
D129.	B	C	D
D130.	B	C	**
D131.	B	C	**
D132.	B	C	**
D133.	C	—	—
D134.	B	C	**
D135.	B	**	**
D136.	B	C	**
D137.	B	C	**
D138.	B	C	**
D139.	B	C	**
D140.	C	—	—
D141.	A	B	**
D142.	C	—	—
D143.	E	—	—
D144.	C	—	—
D145.	B	C	**
D146.	E	—	—
D147.	B	C	D
D148.	B	C	D
D149.	B	C	C
D150.	B	C	**
D151.	B	C	**
D152.	B	C	**
D153.	C	—	—
D154.	B	C	—
D155.	C	—	—
D156.	B	C	D
D157.	C	—	—
D158.	C	—	—
D159.	C	—	—
D160.	C	C	**
D161.	C	C	**
D162.	C	C	**
D163.	C	C	—
D164.	C	C	—
D165.	C	—	—
D166.	C	D	**
D167.	B	C	**
D168.	B	D	**
D169.	B	B	**
D170.	B	C	**
D171.	B	C	**
D172.	B	C	**
D173.	B	C	C
D174.	A	B	C
D175.	C	—	—
D176.	A	B	**
D177.	D	—	—
D178.	E	—	—
D179.	B	—	**
D180.	C	**	**
D181.	C	—	—
D182.	C	C	**
D183.	C	C	**
D184.	C	—	—
D185.	B	C	D
D186.	B	C	**
D187.	B	C	**
D188.	B	C	D
D189.	A	B	B
D190.	C	—	—
D191.	B	B	C
D192.	C	—	—
D193.	E	—	—
D194.	C	—	—
D195.	C	—	—
D196.	C	—	—
D197.	C	—	—
D198.	D	—	—
D199.	A	A	C
D200.	B	D	**
D201.	B	C	**
D202.	E	—	—
D203.	C	—	—
D204.	C	—	—
D205.	B	B	**
D206.	C	—	—
D207.	B	B	C
D208.	B	C	C
D209.	A	B	C
D210.	A	B	D
D211.	C	—	—
D212.	C	—	—
D213.	C	—	—
D214.	C	—	—
D215.	C	—	—
D216.	B	C	**
D217.	B	C	D
D218.	A	B	C
D219.	A	B	C
D220.	A	B	C
D221.	A	B	C
D222.	B	B	D
D223.	A	B	D
D224.	B	B	**
D225.	E	—	—
D226.	A	B	C
D227.	A	—	—
D228.	B	—	—
D229.	A	—	—
D230.	A	—	—
D231.	B	—	—
D232.	B	—	—
D233.	A	A	C
D234.	A	A	B
D235.	B	B	D
D236.	A	B	C
D237.	B	B	D
D238.	A	A	C
D239.	A	A	C
D240.	A	B	C
D241.	A	B	C
D242.	B	B	C
D243.	B	B	C
D244.	B	B	D
D245.	A	B	C
D246.	A	A	B
D247.	A	A	C
D248.	B	B	D
D249.	B	B	D
D250.	A	B	C
D251.	A	B	C
D252.	A	B	C
D253.	A	B	C
D254.	A	B	C
D255.	A	A	B
D256.	A	A	B
D257.	A	B	C
D258.	B	C	**
D259.	B	B	D
D260.	C	—	—
D261.	A	B	D
D262.	B	C	C
D263.	B	B	D
D264.	B	C	C
D265.	A	B	C
D266.	A	C	C
D267.	B	—	—
D268.	C	—	—
D269.	A	B	D
D270.	B	B	D
D271.	B	B	**
D272.	B	B	C
D273.	A	B	D
D274.	C	—	—
D275.	A	B	C
D276.	B	C	C
D277.	*	—	—
D278.	C	—	—
D279.	C	—	—
D280.	C	—	D
D281.	C	—	—
D282.	D	—	—
D283.	D	—	—
D284.	D	—	—
D285.	C	—	**
D286.	B	—	**
D287.	C	—	—
D288.	C	—	E
D289.	E	—	E
D290.	C	—	E
D291.	C	—	E
D292.	C	—	E
D293.	E	—	E
D294.	C	—	E
D295.	E	—	E
D296.	E	—	—
D297.	E	—	E
D298.	E	—	E
D299.	D	—	E
D300.	B	—	E
D301.	C	—	E
D302.	C	—	—
D303.	C	—	E
D304.	E	—	E
D305.	D	—	E
D306.	E	—	E
D307.	E	—	E
D308.	D	—	E
D309.	C	—	E
D310.	D	—	E
For Table D-2, “A” indicates an IC50 or EC50 < 0.100 μM, “B” indicates an IC50 or EC50 of 0.101-1.000 μM, “C” indicates an IC50 or EC50 of 1.001-10.000 μM, “D” indicates an IC50 or EC50 of 10.001-40 μM, and “E” indicates an IC50 or EC50 > 40 μM.
“—” indicates no data shown.
“*” indicates an IC50 or EC50 > 10 μM.
“**” indicates an IC50 or EC50 > 20 μM.

Results for certain compounds described herein are shown in Table E-2.

TABLE E-2
Biological Assay Results
Cmpd No	Biochemical IC50	ICW EC50	Proliferation EC50
E1.	C	—	—
E2.	C	—	—
E3.	C	—	—
E4.	A	B	C
E5.	A	B	C
E6.	*	—	—
E7.	B	B	**
E8.	B	B	—
E9.	C	—	—
E10.	B	B	**
E11.	B	C	—
E12.	B	B	—
E13.	B	C	**
E14.	D	—	—
E15.	A	B	C
E16.	C	—	—
E17.	C	—	—
E18.	C	—	—
E19.	B	C	**
E20.	C	—	D
For Table E-2, “A” indicates an IC50 or EC50 < 0.100 μM, “B” indicates an IC50 or EC50 of 0.101-1.000 μM, “C” indicates an IC50 or EC50 of 1.001-10.000 μM, “D” indicates an IC50 or EC50 of 10.001-50 μM, and “E” indicates an IC50 or EC50 > 50 μM.
“—” indicates no data shown.
“*” indicates an IC50 or EC50 > 10 μM.
“**” indicates an IC50 or EC50 > 20 μM.

Other Embodiments

The foregoing has been a description of certain non-limiting embodiments of the invention. Those of ordinary skill in the art will appreciate that various changes and modifications to this description may be made without departing from the spirit or scope of the present invention, as defined in the following claims.

TABLE A
Untitled
HEADER	----	XX-XXX-XX   XXXX
COMPND	---
REMARK	3
REMARK	3	REFINEMENT.
REMARK	3	PROGRAM	: REFMAC 5.7.0029
REMARK	3	AUTHORS	: NURSHUDOV, SKUBAK, LEBEDEV, PANNU,
REMARK	3		STEINER, NICHOLLS, WINN, LONG, VAGIN
REMARK	3
REMARK	3	REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK	3
REMARK	3	DATA USED IN REFINEMENT.
REMARK	3	RESOLUTION RANGE HIGH	(ANGSTROMS)	:  2.39
REMARK	3	RESOLUTION RANGE LOW	(ANGSTROMS)	:  41.37
REMARK	3	DATA CUTOFF	(SIGMA(F))	: NONE
REMARK	3	COMPLETENESS FOR RANGE	(%)	:  99.59
REMARK	3	NUMBER OF REFLECTIONS		:  48207
REMARK	3
REMARK	3	FIT TO DATA USED IN REFINEMENT.
REMARK	3	CROSS-VALIDATION METHOD	: THROUGHOUT
REMARK	3	FREE R VALUE TEST SET SELECTION	: RANDOM
REMARK	3	R VALUE	(WORKING + TEST SET)	: 0.21203
REMARK	3	R VALUE	(WORKING SET)	:  0.20841
REMARK	3	FREE R VALUE	:  0.28210
REMARK	3	FREE R VALUE TEST SET SIZE	(%)	:  5.1
REMARK	3	FREE R VALUE TEST SET COUNT	:  2579
REMARK	3
REMARK	3	FIT IN THE HIGHEST RESOLUTION BIN.
REMARK	3	TOTAL NUMBER OF BINS USED	:	20
REMARK	3	BIN RESOLUTION RANGE HIGH	:	2.390
REMARK	3	BIN RESOLUTION RANGE LOW	:	2.452
REMARK	3	REFLECTION IN BIN	(WORKING SET)	:	3459
REMARK	3	BIN COMPLETENESS	(WORKING + TEST) (%)	:	98.89
REMARK	3	BIN R VALUE	(WORKING SET)	:	0.360
REMARK	3	BIN FREE R VALUE SET COUNT	:	202
REMARK	3	BIN FREE R VALUE	:	0.426
REMARK	3
REMARK	3	NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK	3	ALL ATOMS	:	7699
REMARK	3
REMARK	3	B VALUES.
REMARK	3	FROM WILSON PLOT	(A**2)	: NULL
REMARK	3	MEAN B VALUE	(OVERALL, A**2)	:  52.795
REMARK	3	OVERALL ANISOTROPIC B VALUE.
REMARK	3	B11 (A**2)  :	0.25
REMARK	3	B22 (A**2)  :	−0.06
REMARK	3	B33 (A**2)  :	−0.19
REMARK	3	B12 (A**2)  :	0.00
REMARK	3	B13 (A**2)  :	0.00
REMARK	3	R23 (A**2)  :	0.00
REMARK	3
REMARK	3	ESTIMATED OVERALL COORDINATE ERROR.
REMARK	3	ESU BASED ON R VALUE	(A):	0.338
REMARK	3	ESU BASED ON FREE R VALUE	(A):	0.275
REMARK	3	ESU BASED ON MAXIMUM LIKELIHOOD	(A):	0.233
REMARK	3	ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD	(A**2):	10.464
REMARK	3
REMARK	3	CORRELATION COEFFICIENTS.
REMARK	3	CORRELATION COEFFICIENT FO-FC	:  0.952
REMARK	3	CORRELATION COEFFICIENT FO-FC FREE	:  0.910
REMARK	3
REMARK	3	RMS DEVIATIONS FROM IDEAL VALUES		COUNT	RMS	WEIGHT
REMARK	3	BOND LENGTHS REFINED ATOMS	(A):	7771;	0.009;	0.019
REMARK	3	BOND ANGLES REFINED ATOMS	(DEGREES):	10600;	1.413;	1.958
REMARK	3	TORSION ANGLES, PERIOD 1	(DEGREES):	952;	6.919;	5.000
REMARK	3	TORSION ANGLES, PERIOD 2	(DEGREES):	356;	35.525;	24.017
REMARK	3	TORSION ANGLES, PERIOD 3	(DEGREES):	1244;	18.128;	15.000
REMARK	3	TORSION ANGLES, PERIOD 4	(DEGREES):	47;	19.255;	15.000
REMARK	3	CHIRAL-CENTER RESTRAINTS	(A**3):	1163;	0.093;	0.200
REMARK	3	GENERAL PLANES REFINED ATOMS	(A):	5985;	0.006;	0.021
REMARK	3
REMARK	3	ISOTROPIC THERMAL FACTOR RESTRAINTS.	COUNT	RMS	WEIGHT
REMARK	3
REMARK	3	NCS RESTRAINTS STATISTICS
REMARK	3	NUMBER OF NCS GROUPS : NULL
REMARK	3
REMARK	3	TWIN DETAILS
REMARK	3	NUMBER OF TWIN DOMAINS : NULL
REMARK	3
REMARK	3
REMARK	3	TLS DETAILS
REMARK	3	NUMBER OF TLS GROUPS : NULL
REMARK	3
REMARK	3
REMARK	3	BULK SOLVENT MODELLING.
REMARK	3	METHOD USED : MASK
REMARK	3	PARAMETERS FOR MASK CALCULATION
REMARK	3	VDW PROBE RADIUS	:	1.20
REMARK	3	ION PROBE RADIUS	:	0.80
REMARK	3	SHRINKAGE RADIUS	:	0.80
REMARK	3
REMARK	3	OTHER REFINEMENT REMARKS:
REMARK	3	HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
REMARK	3	U VALUES  : REFINED INDIVIDUALLY
REMARK	3
SSBOND	1	CYS	B	247	CYS	B	208
CISPEP	1	GLU	A	57	PRO	A	58	0.00
CISPEP	2	GLY	A	64	PRO	A	65	0.00
CISPEP	3	ILE	A	464	PRO	A	465	0.00
CISPEP	4	HIS	A	523	PRO	A	524	0.00
CISPEP	5	ALA	A	619	PRO	A	620	0.00
CISPEP	6	ALA	B	67	PRO	B	68	0.00
CRYST1	103.400 138.130 178.920 90.00 90.00 90.00	I 2 2 2
SCALE1	0.009671 0.000000 0.000000     0.00000
SCALE2	0.000000 0.007740 0.000000     0.00000
SCALE3	0.000000 0.000000 0.005589     0.00000
ATOM	1	N	ARG	A	13	40.231	−69.664	−17.513	1.00	90.11	N
ATOM	2	CA	ARG	A	13	40.367	−69.723	−19.001	1.00	91.57	C
ATOM	3	CB	ARG	A	13	41.647	−70.468	−19.418	1.00	99.54	C
ATOM	4	CG	ARG	A	13	42.824	−70.300	−18.469	1.00	103.69	C
ATOM	5	CD	ARG	A	13	42.870	−71.403	−17.419	1.00	102.49	C
ATOM	6	NE	ARG	A	13	43.736	−72.505	−17.836	1.00	115.87	N
ATOM	7	CZ	ARG	A	13	45.053	−72.561	−17.614	1.00	123.49	C
ATOM	8	NH1	ARG	A	13	45.759	−73.508	−18.035	1.00	121.07	N
ATOM	9	NH2	ARG	A	13	45.674	−71.573	−16.974	1.00	127.94	N
ATOM	10	C	ARG	A	13	39.140	−70.424	−19.570	1.00	85.13	C
ATOM	11	O	ARG	A	13	38.027	−69.906	−19.476	1.00	82.98	O
ATOM	12	N	VAL	A	14	39.341	−71.506	−20.143	1.00	74.74	N
ATOM	13	CA	VAL	A	14	38.239	−72.385	−20.680	1.00	66.66	C
ATOM	14	CB	VAL	A	14	38.466	−72.722	−22.162	1.00	63.40	C
ATOM	15	CG1	VAL	A	14	37.403	−73.583	−22.669	1.00	63.40	C
ATOM	16	CG2	VAL	A	14	38.441	−71.457	−22.979	1.00	62.45	C
ATOM	17	C	VAL	A	14	38.057	−73.676	−19.897	1.00	63.08	C
ATOM	18	O	VAL	A	14	38.982	−74.482	−19.802	1.00	64.30	O
ATOM	19	N	SER	A	15	36.864	−73.858	−19.338	1.00	54.68	N
ATOM	20	CA	SER	A	15	36.473	−75.135	−18.760	1.00	51.93	C
ATOM	21	CB	SER	A	15	35.403	−74.956	−17.687	1.00	52.49	C
ATOM	22	OG	SER	A	15	35.360	−76.087	−16.844	1.00	54.48	O
ATOM	23	C	SER	A	15	35.964	−76.025	−19.879	1.00	49.02	C
ATOM	24	O	SER	A	15	35.121	−75.622	−20.680	1.00	50.25	O
ATOM	25	N	SER	A	16	36.489	−77.235	−19.934	1.00	46.39	N
ATOM	26	CA	SER	A	16	36.263	−78.108	−21.059	1.00	46.79	C
ATOM	27	CB	SER	A	16	37.373	−77.904	−22.067	1.00	54.99	C
ATOM	28	OG	SER	A	16	38.597	−78.114	−21.491	1.00	65.11	O
ATOM	29	C	SER	A	16	36.271	−75.548	−20.593	1.00	44.94	C
ATOM	30	O	SER	A	16	36.948	−79.885	−19.632	1.00	48.25	O
ATOM	31	N	GLY	A	17	35.514	−80.404	−21.273	1.00	43.14	N
ATOM	32	CA	GLY	A	17	35.422	−81.810	−20.875	1.00	37.29	C
ATOM	33	C	GLY	A	17	35.626	−82.689	−22.080	1.00	38.75	C
ATOM	34	O	GLY	A	17	35.524	−82.223	−23.714	1.00	40.58	O
ATOM	35	N	ARG	A	18	35.947	−83.958	−21.343	1.00	41.31	N
ATOM	36	CA	ARG	A	18	36.067	−84.944	−22.918	1.00	42.34	C
ATOM	37	CB	ARG	A	18	37.282	−85.847	−22.674	1.00	45.27	C
ATOM	38	CG	ARG	A	18	37.482	−86.949	−23.714	1.00	44.17	C
ATOM	39	CD	ARG	A	18	38.144	−86.403	−24.971	1.00	47.47	C
ATOM	40	NE	ARG	A	18	38.462	−87.492	−25.885	1.00	54.42	N
ATOM	41	CZ	ARG	A	18	37.834	−87.727	−27.032	1.00	52.83	C
ATOM	42	NH1	ARG	A	18	36.845	−86.943	−27.441	1.00	52.72	N
ATOM	43	NH2	ARG	A	18	38.199	−88.762	−27.770	1.00	54.41	N
ATOM	44	C	ARG	A	18	34.811	−85.808	−22.989	1.00	42.63	C
ATOM	45	O	ARG	A	18	34.305	−86.278	−21.967	1.00	46.05	O
ATOM	46	N	ASP	A	19	34.307	−86.035	−24.191	1.00	44.38	N
ATOM	47	CA	ASP	A	19	33.152	−86.904	−24.323	1.00	43.07	C
ATOM	48	CB	ASP	A	19	32.088	−86.304	−25.254	1.00	42.92	C
ATOM	49	CG	ASP	A	19	30.951	−87.295	−25.542	1.00	39.47	C
ATOM	50	CD1	ASP	A	19	30.436	−87.883	−24.571	1.00	38.24	O
ATOM	51	CD2	ASP	A	19	30.624	−87.523	−26.729	1.00	38.71	O
ATOM	52	C	ASP	A	19	33.553	−88.269	−24.831	1.00	41.15	C
ATOM	53	O	ASP	A	19	33.970	−88.407	−25.965	1.00	46.41	O
ATOM	54	N	LEU	A	20	33.391	−89.288	−24.005	1.00	42.15	N
ATOM	55	CA	LEU	A	20	33.737	−90.634	−24.430	1.00	44.12	C
ATOM	56	CB	LEU	A	20	34.843	−91.221	−23.550	1.00	45.75	C
ATOM	57	CG	LEU	A	20	36.167	−90.485	−23.656	1.00	51.98	C
ATOM	58	CD1	LEU	A	20	37.184	−91.164	−22.760	1.00	56.66	C
ATOM	59	CD2	LEU	A	20	36.640	−90.447	−25.104	1.00	56.56	C
ATOM	60	C	LEU	A	20	32.541	−91.541	−24.378	1.00	44.35	C
ATOM	61	O	LEU	A	20	31.721	−91.450	−23.463	1.00	44.85	O
ATOM	62	N	ASN	A	21	32.458	−92.453	−25.332	1.00	43.05	N
ATOM	63	CA	ASN	A	21	31.398	−93.418	−25.270	1.00	44.96	C
ATOM	64	CB	ASN	A	21	30.444	−93.280	−26.457	1.00	47.44	C
ATOM	65	CG	ASN	A	21	29.042	−93.773	−26.129	1.00	48.74	C
ATOM	66	CD1	ASN	A	21	28.500	−93.487	−25.054	1.00	47.63	O
ATOM	67	ND2	ASN	A	21	28.454	−94.537	−27.049	1.00	47.32	N
ATOM	68	C	ASN	A	21	31.940	−94.826	−25.110	1.00	47.57	C
ATOM	69	O	ASN	A	21	31.220	−95.795	−25.401	1.00	42.52	O
ATOM	70	N	CYS	A	22	33.198	−94.906	−24.628	1.00	45.93	N
ATOM	71	CA	CYS	A	22	33.921	−96.160	−24.323	1.00	46.67	C
ATOM	72	CB	CYS	A	22	34.687	−96.659	−25.561	1.00	53.16	C
ATOM	73	SG	CYS	A	22	35.916	−97.979	−25.258	1.00	47.99	S
ATOM	74	C	CYS	A	22	34.920	−95.994	−23.159	1.00	46.07	C
ATOM	75	O	CYS	A	22	35.904	−95.247	−23.282	1.00	43.39	O
ATOM	76	N	VAL	A	23	31.677	−96.689	−22.044	1.00	46.76	N
ATOM	77	CA	VAL	A	23	35.536	−96.566	−20.856	1.00	51.47	C
ATOM	78	CB	VAL	A	23	34.926	−95.667	−19.761	1.00	54.45	C
ATOM	79	CG1	VAL	A	23	35.880	−95.578	−18.568	1.00	55.35	C
ATOM	80	CG2	VAL	A	23	34.635	−94.280	−20.299	1.00	54.00	C
ATOM	81	C	VAL	A	23	35.838	−97.923	−20.240	1.00	51.91	C
ATOM	82	O	VAL	A	23	35.068	−98.403	−19.398	1.00	54.29	O
ATOM	83	N	PRO	A	24	36.956	−98.553	−20.666	1.00	53.39	N
ATOM	84	CA	PRO	A	24	37.309	−99.901	−20.191	1.00	50.15	C
ATOM	85	CB	PRO	A	24	38.543	−100.256	−21.037	1.00	50.52	C
ATOM	86	CG	PRO	A	24	38.395	−99.412	−22.280	1.00	49.94	C
ATOM	87	CD	PRO	A	24	37.852	−98.112	−21.758	1.00	50.44	C
ATOM	88	C	PRO	A	24	37.612	−99.949	−18.690	1.00	49.61	C
ATOM	89	O	PRO	A	24	37.123	−100.837	−17.982	1.00	47.73	O
ATOM	80	N	GLU	A	25	38.395	−98.995	−18.203	1.00	49.73	N
ATOM	81	CA	GLU	A	25	36.641	−98.906	−16.778	1.00	52.26	C
ATOM	82	CB	GLU	A	25	39.972	−99.567	−16.410	1.00	63.06	C
ATOM	83	CG	GLU	A	25	40.024	−100.117	−14.991	1.00	76.38	C
ATOM	84	CD	GLU	A	25	40.888	−101.368	−14.891	1.00	88.79	C
ATOM	85	OE1	GLU	A	25	42.117	−101.239	−14.669	1.00	85.79	O
ATOM	86	OE2	GLU	A	25	40.330	−102.485	−15.037	1.00	93.22	O
ATOM	87	C	GLU	A	25	30.622	−97.448	−16.377	1.00	50.60	C
ATOM	88	O	GLU	A	25	39.435	−96.644	−16.853	1.00	47.08	O
ATOM	89	N	ILE	A	26	37.687	−97.126	−15.490	1.00	48.75	N
ATOM	100	CA	ILE	A	26	37.386	−95.742	−15.098	1.00	50.56	C
ATOM	101	C8	ILE	A	26	36.137	−95.694	−14.173	1.00	51.46	C
ATOM	102	CG1	ILE	A	26	35.619	−94.275	−14.007	1.00	50.20	C
ATOM	103	CD1	ILE	A	26	34.189	−94.242	−13.516	1.00	55.64	C
ATOM	104	CG2	ILE	A	26	36.439	−96.298	−12.811	1.00	58.67	C
ATOM	105	C	ILE	A	26	38.575	−94.960	−14.506	1.00	47.79	C
ATOM	106	O	ILE	A	26	38.845	−93.828	−14.916	1.00	49.26	O
ATOM	107	N	ALA	A	27	39.266	−95.571	−13.548	1.00	51.56	N
ATOM	108	CA	ALA	A	27	40.511	−95.041	−12.973	1.00	51.31	C
ATOM	109	CB	ALA	A	27	41.209	−96.124	−12.157	1.00	52.36	C
ATOM	110	C	ALA	A	27	41.454	−94.549	−14.047	1.00	49.09	C
ATOM	111	O	ALA	A	27	41.858	−93.395	−14.033	1.00	46.70	O
ATOM	112	N	ASP	A	28	41.792	−95.444	−14.974	1.00	51.57	N
ATOM	113	CA	ASP	A	28	42.753	−95.162	−16.033	1.00	54.74	C
ATOM	114	CB	ASP	A	28	43.062	−96.417	−16.845	1.00	62.89	C
ATOM	115	CG	ASP	A	28	43.928	−97.456	−16.064	1.00	72.12	C
ATOM	116	OD1	ASP	A	28	44.749	−97.027	−15.212	1.00	71.84	O
ATOM	117	OD2	ASP	A	28	43.794	−98.683	−16.314	1.00	66.96	O
ATOM	118	C	ASP	A	28	42.286	−94.035	−16.947	1.00	55.22	C
ATOM	119	O	ASP	A	28	43.008	−93.043	−17.156	1.00	53.26	O
ATOM	120	N	THR	A	29	41.067	−94.182	−17.469	1.00	56.49	N
ATOM	121	CA	THR	A	29	40.500	−93.217	−18.415	1.00	55.16	C
ATOM	122	CB	THR	A	29	39.079	−93.618	−18.847	1.00	56.25	C
ATOM	123	OG1	THR	A	29	39.087	−94.958	−19.353	1.00	55.24	O
ATOM	124	CG2	THR	A	29	38.560	−92.679	−19.938	1.00	58.15	C
ATOM	125	C	THR	A	29	40.500	−91.797	−17.844	1.00	55.34	C
ATOM	126	O	THR	A	29	40.972	−90.855	−18.490	1.00	53.61	O
ATOM	127	N	LEU	A	30	39.985	−91.663	−16.624	1.00	55.91	N
ATOM	128	CA	LEU	A	30	39.960	−90.391	−15.928	1.00	53.25	C
ATOM	129	CB	LEU	A	30	39.294	−90.548	−14.561	1.00	51.97	C
ATOM	130	CG	LEU	A	30	38.833	−89.248	−13.899	1.00	54.50	C
ATOM	131	CD1	LEU	A	30	38.095	−88.345	−14.890	1.00	51.69	C
ATOM	132	CD2	LEU	A	30	37.997	−89.530	−12.649	1.00	52.12	C
ATOM	133	C	LEU	A	30	41.359	−89.799	−15.790	1.00	53.75	C
ATOM	134	O	LEU	A	30	41.550	−88.602	−15.996	1.00	56.18	O
ATOM	135	N	GLY	A	31	42.340	−90.635	−15.459	1.00	56.22	N
ATOM	136	CA	GLY	A	31	43.730	−90.185	−15.414	1.00	52.35	C
ATOM	137	C	GLY	A	31	44.191	−89.685	−16.772	1.00	53.05	C
ATOM	138	O	GLY	A	31	44.752	−88.593	−16.884	1.00	58.21	O
ATOM	139	N	ALA	A	32	43.941	−90.476	−17.812	1.00	52.01	N
ATOM	140	CA	ALA	A	32	44.362	−90.108	−19.160	1.00	55.50	C
ATOM	141	CB	ALA	A	32	43.901	−91.146	−20.171	1.00	55.48	C
ATOM	142	C	ALA	A	32	43.862	−88.720	−19.544	1.00	59.96	C
ATOM	143	O	ALA	A	32	44.660	−87.857	−19.962	1.00	62.06	O
ATOM	144	N	VAL	A	33	42.554	−88.499	−19.370	1.00	58.96	N
ATOM	145	CA	VAL	A	33	41.927	−87.237	−19.792	1.00	56.97	C
ATOM	146	CB	VAL	A	33	40.365	−87.294	−19.918	1.00	53.93	C
ATOM	147	CG1	VAL	A	33	39.889	−88.588	−20.582	1.00	50.72	C
ATOM	148	CG2	VAL	A	33	39.674	−87.005	−18.587	1.00	48.46	C
ATOM	149	C	VAL	A	33	42.348	−86.069	−18.914	1.00	56.79	C
ATOM	150	C	VAL	A	33	42.431	−84.938	−19.398	1.00	63.24	O
ATOM	151	N	ALA	A	34	42.614	−81.335	−17.636	1.00	53.84	N
ATOM	152	CA	ALA	A	34	43.066	−85.283	−16.735	1.00	56.78	C
ATOM	153	CB	ALA	A	34	43.033	−85.759	−15.296	1.00	57.34	C
ATOM	154	C	ALA	A	34	44.470	−84.826	−17.139	1.00	62.40	C
ATOM	155	C	ALA	A	34	44.711	−83.627	−17.306	1.00	63.87	O
ATOM	156	N	LYS	A	35	45.374	−85.791	−17.326	1.00	67.37	N
ATOM	157	CA	LYS	A	35	46.716	−85.530	−17.856	1.00	73.82	C
ATOM	158	CB	LYS	A	35	47.504	−86.854	−18.044	1.00	78.84	C
ATOM	159	CG	LYS	A	35	48.303	−87.021	−19.342	1.00	85.82	C
ATOM	160	CD	LYS	A	35	49.667	−86.331	−19.315	1.00	88.65	C
ATOM	161	CE	LYS	A	35	50.324	−86.339	−20.693	1.00	86.24	C
ATOM	162	NZ	LYS	A	35	51.261	−85.191	−20.877	1.00	77.49	N
ATOM	163	C	LYS	A	35	46.618	−84.711	−19.141	1.00	69.94	C
ATOM	164	O	LYS	A	35	47.367	−83.752	−19.325	1.00	67.05	O
ATOM	165	N	GLN	A	36	45.667	−85.074	−20.001	1.00	67.46	N
ATOM	166	CA	GLN	A	36	45.458	−84.372	−21.274	1.00	63.74	C
ATOM	167	CB	GLN	A	36	44.483	−85.139	−22.163	1.00	65.83	C
ATOM	168	CG	GLN	A	36	45.081	−86.370	−22.832	1.00	67.27	C
ATOM	169	CD	GLN	A	36	44.030	−87.263	−23.495	1.00	77.35	C
ATOM	170	0E1	GLN	A	36	42.912	−86.826	−23.806	1.00	73.26	O
ATOM	171	NE2	GLN	A	36	44.390	−88.526	−23.717	1.00	76.70	N
ATOM	172	C	GLN	A	36	45.019	−82.912	−21.132	1.00	62.16	C
ATOM	173	O	GLN	A	36	45.178	−82.136	−22.068	1.00	66.17	O
ATOM	174	N	GLY	A	37	44.482	−82.533	−19.972	1.00	62.21	N
ATOM	175	CA	GLY	A	37	44.135	−81.126	−19.707	1.00	58.15	C
ATOM	176	C	GLY	A	37	42.675	−80.847	−19.371	1.00	57.47	C
ATOM	177	O	GLY	A	37	42.357	−79.785	−18.835	1.00	55.08	O
ATOM	178	N	PHE	A	38	41.800	−81.812	−19.670	1.00	53.21	N
ATOM	179	CA	PHE	A	38	40.354	−81.718	−19.442	1.00	51.67	C
ATOM	180	CB	PHE	A	38	39.661	−82.916	−20.038	1.00	50.27	C
ATOM	181	CG	PHE	A	38	39.703	−83.013	−21.544	1.00	48.49	C
ATOM	182	CD1	PHE	A	38	38.892	−82.170	−22.331	1.00	46.35	C
ATOM	183	CE1	PHE	A	38	38.929	−82.216	−23.700	1.00	46.39	C
ATOM	184	C1	PHE	A	38	39.782	−83.112	−24.341	1.00	49.64	C
ATOM	185	CE2	PHE	A	38	40.594	−83.965	−21.592	1.00	48.14	C
ATOM	186	CD2	PHE	A	38	40.551	−83.910	−22.202	1.00	49.31	C
ATOM	187	C	PHE	A	38	39.888	−81.528	−17.985	1.00	53.90	C
ATOM	188	O	PHE	A	38	40.386	−82.197	−17.068	1.00	54.54	O
ATOM	189	N	ASP	A	39	38.901	−80.645	−17.789	1.00	54.37	N
ATOM	190	CA	ASP	A	39	38.264	−80.432	−16.467	1.00	51.80	C
ATOM	191	CB	ASP	A	39	37.487	−79.121	−16.425	1.00	57.11	C
ATOM	192	CG	ASP	A	39	38.368	−77.927	−16.341	1.00	61.82	C
ATOM	193	OD1	ASP	A	39	39.368	−78.040	−16.649	1.00	68.92	O
ATOM	194	OD2	ASP	A	39	37.850	−76.857	−15.973	1.00	75.96	O
ATOM	195	C	ASP	A	39	37.312	−81.534	−16.043	1.00	43.15	C
ATOM	196	O	ASP	A	39	37.101	−81.748	−14.854	1.00	41.16	O
ATOM	197	N	PHE	A	40	36.731	−82.228	−17.010	1.00	41.65	N
ATOM	198	CA	PHE	A	40	35.733	−83.265	−16.705	1.00	42.72	C
ATOM	199	CB	PHE	A	40	34.381	−82.642	−16.271	1.00	41.97	C
ATOM	200	CG	PHE	A	40	33.673	−81.880	−17.361	1.00	40.15	C
ATOM	201	CD1	PHE	A	40	33.988	−80.550	−17.620	1.00	40.52	C
ATOM	202	CE1	PHE	A	40	33.329	−79.845	−18.637	1.00	43.10	C
ATOM	203	CZ	PHE	A	40	32.337	−80.472	−19.396	1.00	39.60	C
ATOM	204	CE2	PHE	A	40	32.009	−81.802	−19.145	1.00	39.17	C
ATOM	205	CD2	PHE	A	40	32.674	−82.499	−18.132	1.00	42.51	C
ATOM	206	C	PHE	A	40	35.517	−84.222	−17.866	1.00	41.30	C
ATOM	207	O	PHE	A	40	35.869	−83.929	−19.010	1.00	41.24	O
ATOM	208	N	LEU	A	41	34.902	−85.347	−17.548	1.00	41.82	N
ATOM	209	CA	LEU	A	41	34.667	−86.429	−18.476	1.00	45.56	C
ATOM	210	CB	LEU	A	41	35.328	−87.708	−17.925	1.00	44.26	C
ATOM	211	CG	LEU	A	41	35.120	−88.971	−18.767	1.00	44.01	C
ATOM	212	CD1	LEU	A	41	35.645	−88.779	−20.188	1.00	41.49	C
ATOM	213	CD2	LEU	A	41	35.755	−90.192	−18.122	1.00	43.26	C
ATOM	214	C	LEU	A	41	33.180	−86.699	−18.620	1.00	46.17	C
ATOM	215	O	LEU	A	41	32.469	−86.747	−17.604	1.00	45.56	O
ATOM	216	N	CYS	A	42	32.713	−86.893	−19.861	1.00	43.71	N
ATOM	217	CA	CYS	A	42	31.341	−87.375	−20.102	1.00	43.71	C
ATOM	218	CB	CYS	A	42	30.605	−86.536	−21.141	1.00	40.61	C
ATOM	219	SG	CYS	A	42	30.860	−84.769	−21.005	1.00	41.12	S
ATOM	220	C	CYS	A	42	31.338	−88.827	−20.550	1.00	45.55	C
ATOM	221	O	CYS	A	42	31.890	−89.170	−21.590	1.00	49.51	O
ATOM	222	N	MET	A	43	30.678	−89.676	−19.781	1.00	47.78	N
ATOM	223	CA	MET	A	43	30.769	−91.102	−20.001	1.00	44.97	C
ATOM	224	CB	MET	A	43	31.957	−91.665	−19.237	1.00	49.85	C
ATOM	225	CG	MET	A	43	32.133	−91.098	−17.845	1.00	50.50	C
ATOM	226	SD	MET	A	43	33.153	−92.182	−16.826	1.00	53.81	S
ATOM	227	CE	MET	A	43	31.902	−93.270	−16.131	1.00	47.86	C
ATOM	228	C	MET	A	43	29.512	−91.830	−19.573	1.00	45.32	C
ATOM	229	O	MET	A	43	28.711	−91.303	−18.813	1.00	44.80	O
ATOM	230	N	PRO	A	44	29.337	−93.051	−20.077	1.00	43.19	N
ATOM	231	CA	PRO	A	44	28.222	−93.908	−19.719	1.00	44.54	C
ATOM	232	CB	PRO	A	44	28.460	−95.148	−20.581	1.00	43.57	C
ATOM	233	CG	PRO	A	44	29.166	−94.606	−21.775	1.00	42.01	C
ATOM	234	CD	PRO	A	44	30.094	−93.580	−21.225	1.00	41.10	C
ATOM	235	C	PRO	A	44	28.277	−94.293	−18.255	1.00	44.82	C
ATOM	236	O	PRO	A	44	29.366	−94.437	−17.711	1.00	44.07	O
ATOM	237	N	VAL	A	45	27.116	−94.471	−17.630	1.00	40.28	N
ATOM	238	CA	VAL	A	45	27.090	−94.985	−16.235	1.00	40.48	C
ATOM	239	CB	VAL	A	45	26.128	−94.157	−15.323	1.00	42.97	C
ATOM	240	CG1	VAL	A	45	26.786	−92.366	−14.857	1.00	43.68	C
ATOM	241	CG2	VAL	A	45	24.785	−93.370	−15.985	1.00	44.34	C
ATOM	242	C	VAL	A	45	26.775	−96.460	−16.241	1.00	38.58	C
ATOM	243	O	VAL	A	45	26.968	−97.149	−15.241	1.00	40.05	O
ATOM	244	N	PHE	A	46	26.287	−96.935	−17.375	1.00	36.96	N
ATOM	245	CA	PHE	A	46	26.105	−98.340	−17.666	1.00	39.74	C
ATOM	246	CB	PHE	A	46	24.609	−98.582	−17.774	1.00	38.39	C
ATOM	247	CG	PHE	A	46	23.906	−98.719	−16.446	1.00	37.43	C
ATOM	248	CD1	PHE	A	46	23.769	−97.563	−15.678	1.00	37.41	C
ATOM	249	CE1	PHE	A	46	23.137	−97.603	−14.445	1.00	36.66	C
ATOM	250	CZ	PHE	A	46	22.613	−98.793	−13.968	1.00	37.35	C
ATOM	251	CE2	PHE	A	46	22.733	−99.948	−14.727	1.00	41.05	C
ATOM	252	CD2	PHE	A	46	23.387	−99.909	−15.954	1.00	38.99	C
ATOM	253	C	PHE	A	46	26.790	−98.536	−19.002	1.00	42.15	C
ATOM	254	O	PHE	A	46	26.979	−97.559	−19.735	1.00	45.84	O
ATOM	255	N	HIS	A	47	27.184	−99.770	−19.324	1.00	42.26	N
ATOM	256	CA	HIS	A	47	27.818	−100.027	−20.621	1.00	42.18	C
ATOM	257	CB	HIS	A	47	28.317	−101.464	−20.735	1.00	43.74	C
ATOM	258	CG	HIS	A	47	29.181	−101.705	−21.937	1.00	47.97	C
ATOM	259	ND1	HIS	A	47	28.672	−101.798	−23.215	1.00	51.07	N
ATOM	260	CE1	HIS	A	47	29.659	−102.012	−24.067	1.00	48.12	C
ATOM	261	NE2	HIS	A	47	30.786	−102.082	−23.385	1.00	44.51	N
ATOM	262	CD2	HIS	A	47	30.517	−101.883	−22.053	1.00	42.27	C
ATOM	263	C	HIS	A	47	26.842	−99.724	−21.764	1.00	39.75	C
ATOM	264	O	HIS	A	47	25.714	−100.228	−21.776	1.00	40.75	O
ATOM	265	N	PRO	A	48	27.275	−98.916	−22.731	1.00	35.84	N
ATOM	266	CA	PRO	A	48	26.324	−98.449	−23.738	1.00	37.78	C
ATOM	267	CB	PRO	A	48	27.182	−97.615	−24.685	1.00	36.17	C
ATOM	268	CG	PRO	A	48	28.285	−97.120	−23.825	1.00	36.82	C
ATOM	269	CD	PRO	A	48	28.524	−96.141	−22.742	1.00	35.01	C
ATOM	270	C	PRO	A	48	25.630	−99.546	−24.507	1.00	40.55	C
ATOM	271	O	PRO	A	48	24.569	−99.288	−25.080	1.00	37.73	O
ATOM	272	N	ARG	A	49	26.219	−100.747	−24.536	1.00	38.73	N
ATOM	273	CA	ARG	A	49	25.627	−101.856	−25.306	1.00	38.35	C
ATOM	274	CB	ARG	A	49	26.690	−102.658	−26.073	1.00	36.44	C
ATOM	275	CG	ARG	A	49	27.152	−101.949	−27.329	1.00	40.94	C
ATOM	276	CD	ARG	A	49	28.070	−102.835	−28.149	1.00	44.41	C
ATOM	277	NE	ARG	A	49	29.394	−103.033	−27.538	1.00	39.01	N
ATOM	278	CZ	ARG	A	49	29.868	−104.209	−27.116	1.00	39.18	C
ATOM	279	NH1	ARG	A	49	29.127	−105.321	−27.190	1.00	33.87	N
ATOM	280	NH2	ARG	A	49	31.093	−104.273	−26.593	1.00	36.04	N
ATOM	281	C	ARG	A	49	24.852	−102.787	−24.426	1.00	35.38	C
ATOM	282	C	ARG	A	49	24.274	−103.771	−24.905	1.00	34.53	O
ATOM	283	N	PHE	A	50	24.853	−102.485	−23.133	1.00	33.74	N
ATOM	784	CA	PHE	A	50	24.317	−103.400	−22.149	1.00	35.24	C
ATOM	285	CB	PHE	A	50	25.033	−103.214	−20.799	1.00	33.93	C
ATOM	286	CG	PHE	A	50	24.754	−104.316	−19.810	1.00	38.08	C
ATOM	287	CD1	PHE	A	50	24.516	−105.622	−20.246	1.00	42.56	C
ATOM	288	CE1	PHE	A	50	24.254	−106.648	−19.343	1.00	44.24	C
ATOM	289	CZ	PHE	A	50	24.228	−106.374	−17.985	1.00	45.41	C
ATOM	290	CE2	PHE	A	50	24.463	−105.081	−17.539	1.00	41.34	C
ATOM	291	CD2	PHE	A	50	24.725	−104.060	−18.451	1.00	39.31	C
ATOM	292	C	PHE	A	50	22.773	−103.307	−22.027	1.00	34.60	C
ATOM	293	C	PHE	A	50	22.244	−103.045	−20.960	1.00	37.13	O
ATOM	294	N	LYS	A	51	22.077	−103.541	−23.129	1.00	45.06	N
ATOM	295	CA	LYS	A	51	20.612	−103.528	−23.175	1.00	41.27	C
ATOM	296	CB	LYS	A	51	20.187	−104.084	−24.522	1.00	45.24	C
ATOM	297	CG	LYS	A	51	19.133	−103.291	−25.262	1.00	51.67	C
ATOM	298	CD	LYS	A	51	19.388	−103.388	−26.760	1.00	54.12	C
ATOM	299	CE	LYS	A	51	18.069	−103.394	−27.522	1.00	58.53	C
ATOM	300	NZ	LYS	A	51	18.290	−103.493	−28.991	1.00	63.15	N
ATOM	301	C	LYS	A	51	20.024	−104.393	−22.073	1.00	41.98	C
ATOM	302	O	LYS	A	51	20.302	−105.576	−22.039	1.00	45.08	O
ATOM	303	N	ARG	A	52	19.246	−103.803	−21.159	1.00	46.47	N
ATOM	304	CA	ARG	A	52	18.569	−104.536	−20.064	1.00	44.80	C
ATOM	305	CB	ARG	A	52	18.643	−103.763	−18.752	1.00	43.33	C
ATOM	306	CG	ARG	A	52	19.649	−104.038	−17.895	1.00	47.51	C
ATOM	307	CD	ARG	A	52	20.929	−103.002	−18.118	1.00	48.49	C
ATOM	308	NE	ARG	A	52	20.537	−101.659	−17.685	1.00	42.10	N
ATOM	309	CZ	ARG	A	52	21.089	−100.551	−13.158	1.00	41.16	C
ATOM	310	NH1	ARG	A	52	22.056	−100.615	−19.071	1.00	44.69	N
ATOM	311	NH2	ARG	A	52	20.689	−99.376	−17.724	1.00	43.08	N
ATOM	312	C	ARG	A	52	17.097	−104.787	−20.350	1.00	43.82	C
ATOM	313	O	ARG	A	52	16.489	−104.089	−21.144	1.00	47.99	O
ATOM	314	N	GLU	A	53	16.521	−105.747	−19.633	1.00	44.99	N
ATOM	315	CA	GLU	A	53	15.147	−106.171	−19.818	1.00	42.21	C
ATOM	316	CB	GLU	A	53	15.121	−107.554	−20.471	1.00	39.84	C
ATOM	317	CG	GLU	A	53	13.806	−108.323	−20.352	1.00	41.49	C
ATOM	318	CD	GLU	A	53	12.636	−107.654	−21.076	1.00	43.47	C
ATOM	319	CE1	GLU	A	53	12.834	−107.114	−22.198	1.00	40.20	O
ATOM	320	CE2	GLU	A	53	11.508	−107.673	−20.523	1.00	47.10	O
ATOM	321	C	GLU	A	53	14.464	−106.189	−18.445	1.00	46.48	C
ATOM	322	O	GLU	A	53	15.032	−106.664	−17.476	1.00	50.92	O
ATOM	323	N	PHE	A	54	13.235	−105.679	−18.372	1.00	48.21	N
ATOM	324	CA	PHE	A	54	12.605	−105.366	−17.092	1.00	46.22	C
ATOM	325	CB	PHE	A	54	12.328	−103.857	−16.995	1.00	42.82	C
ATOM	326	CG	PHE	A	54	13.572	−103.020	−16.881	1.00	37.35	C
ATOM	327	CD1	PHE	A	54	14.309	−102.687	−18.017	1.00	33.49	C
ATOM	328	CE1	PHE	A	54	15.460	−101.932	−17.918	1.00	32.31	C
ATOM	329	CZ	PHE	A	54	15.895	−101.492	−16.673	1.00	33.84	C
ATOM	330	CE2	PHE	A	54	15.159	−101.812	−15.535	1.00	34.35	C
ATOM	331	CD2	PHE	A	54	14.006	−102.571	−15.637	1.00	33.21	C
ATOM	332	C	PHE	A	54	11.330	−106.144	−16.821	1.00	48.54	C
ATOM	333	O	PHE	A	54	10.886	−106.208	−15.680	1.00	50.87	O
ATOM	334	N	ILE	A	55	10.760	−106.760	−17.851	1.00	55.42	N
ATOM	335	CA	ILE	A	55	9.471	−107.450	−17.701	1.00	62.63	C
ATOM	336	CB	ILE	A	55	8.343	−106.732	−18.503	1.00	62.09	C
ATOM	337	CG1	ILE	A	55	8.119	−105.305	−17.980	1.00	64.38	C
ATOM	338	CD1	ILE	A	55	8.775	−104.207	−18.808	1.00	68.23	C
ATOM	339	CG2	ILE	A	55	7.035	−107.502	−18.424	1.00	65.00	C
ATOM	340	C	ILE	A	55	9.518	−108.970	−18.002	1.00	65.36	C
ATOM	341	O	ILE	A	55	9.058	−109.779	−17.179	1.00	66.61	O
ATOM	342	N	GLN	A	56	10.085	−109.348	−19.153	1.00	63.62	N
ATOM	343	CA	GLN	A	56	10.000	−110.726	−19.679	1.00	63.14	C
ATOM	344	CB	GLN	A	56	9.980	−110.713	−21.204	1.00	64.39	C
ATOM	345	CG	GLN	A	56	9.110	−111.791	−21.821	1.00	73.54	C
ATOM	346	CD	GLN	A	56	3.908	−111.591	−23.322	1.00	33.96	C
ATOM	347	OE1	GLN	A	56	9.873	−111.522	−74.095	1.00	79.44	O
ATOM	348	NE2	GLN	A	56	7.643	−111.501	−23.743	1.00	87.64	N
ATOM	349	C	GLN	A	56	11.117	−111.651	−19.204	1.00	63.08	C
ATOM	350	O	GLN	A	56	12.307	−111.319	−19.289	1.00	59.16	O
ATOM	351	N	GLU	A	57	10.726	−112.823	−18.709	1.00	65.40	N
ATOM	352	CA	GLU	A	57	11.700	−113.830	−18.289	1.00	65.46	C
ATOM	353	CB	GLU	A	57	11.117	−114.763	−17.215	1.00	65.85	C
ATOM	354	CG	GLU	A	57	11.475	−114.298	−15.800	1.00	70.75	C
ATOM	355	CD	GLU	A	57	10.558	−114.823	−14.695	1.00	78.94	C
ATOM	356	OE1	GLU	A	57	10.823	−114.532	−13.499	1.00	72.74	O
ATOM	357	OE2	GLU	A	57	9.568	−115.522	−15.007	1.00	83.72	O
ATOM	358	C	GLU	A	57	12.255	−114.565	−19.513	1.00	59.83	C
ATOM	359	O	GLU	A	57	11.530	−114.803	−20.469	1.00	59.43	O
ATOM	360	N	PRO	A	58	13.546	−114.927	−19.492	1.00	58.53	N
ATOM	361	CA	PRO	A	58	14.475	−114.928	−18.362	1.00	57.69	C
ATOM	362	CB	PRO	A	58	15.280	−116.205	−18.605	1.00	56.84	C
ATOM	363	CG	PRO	A	58	15.276	−116.373	−20.093	1.00	56.01	C
ATOM	364	CD	PRO	A	58	14.122	−115.604	−20.667	1.00	56.88	C
ATOM	365	C	PRO	A	58	15.431	−113.746	−18.232	1.00	59.55	C
ATOM	366	O	PRO	A	58	16.047	−113.581	−17.168	1.00	60.54	O
ATOM	367	N	ALA	A	59	15.563	−112.947	−19.292	1.00	56.51	N
ATOM	368	CA	ALA	A	59	16.532	−111.845	−19.342	1.00	52.12	C
ATOM	369	CB	ALA	A	59	16.473	−111.159	−20.692	1.00	54.93	C
ATOM	370	C	ALA	A	59	16.318	−110.825	−18.235	1.00	51.91	C
ATOM	371	O	ALA	A	59	17.256	−110.140	−17.808	1.00	58.57	O
ATOM	372	N	LYS	A	60	15.069	−110.714	−17.808	1.00	50.28	N
ATOM	373	CA	LYS	A	60	14.679	−109.972	−16.617	1.00	54.50	C
ATOM	374	CB	LYS	A	60	13.211	−110.311	−16.282	1.00	57.90	C
ATOM	375	CG	LYS	A	60	12.553	−109.469	−15.203	1.00	60.28	C
ATOM	376	CD	LYS	A	60	11.308	−110.163	−14.665	1.00	66.88	C
ATOM	377	CE	LYS	A	60	10.453	−109.235	−13.809	1.00	67.00	C
ATOM	378	NZ	LYS	A	60	11.143	−108.787	−12.567	1.00	64.21	N
ATOM	379	C	LYS	A	60	15.600	−110.351	−15.450	1.00	52.13	C
ATOM	380	O	LYS	A	60	16.160	−109.472	−14.791	1.00	46.29	O
ATOM	381	N	ASN	A	61	15.773	−111.562	−15.230	1.00	52.51	N
ATOM	382	CA	ASN	A	61	16.533	−112.187	−14.082	1.00	48.43	C
ATOM	383	CB	ASN	A	61	15.902	−113.486	−13.570	1.00	47.73	C
ATOM	384	CG	ASN	A	61	14.448	−113.294	−13.132	1.00	55.16	C
ATOM	385	OD1	ASN	A	61	13.582	−114.107	−13.446	1.00	54.81	O
ATOM	386	ND2	ASN	A	61	14.177	−112.203	−12.414	1.00	54.07	N
ATOM	387	C	ASN	A	61	15.042	−112.227	−14.310	1.00	45.33	C
ATOM	388	O	ASN	A	61	18.738	−112.966	−13.538	1.00	44.88	O
ATOM	389	N	ARG	A	61	18.541	−111.703	−15.368	1.00	45.55	N
ATOM	390	CA	ARG	A	62	19.979	−111.576	−15.589	1.00	45.86	C
ATOM	391	CB	ARG	A	62	20.217	−110.464	−16.599	1.00	44.90	C
ATOM	392	CG	ARG	A	62	21.666	−110.163	−16.908	1.00	45.11	C
ATOM	393	CD	ARG	A	62	21.748	−109.975	−18.403	1.00	44.72	C
ATOM	394	NE	ARG	A	62	21.667	−108.582	−18.748	1.00	45.87	N
ATOM	395	CZ	ARG	A	62	21.083	−108.499	−19.832	1.00	46.88	C
ATOM	396	NH1	ARG	A	62	21.105	−106.791	−20.020	1.00	44.27	N
ATOM	397	NH2	ARG	A	62	20.482	−105.900	−20.713	1.00	45.33	N
ATOM	398	C	ARG	A	62	20.742	−111.269	−14.279	1.00	45.84	C
ATOM	399	O	ARG	A	62	20.576	−110.202	−13.698	1.00	43.75	O
ATOM	400	N	PRO	A	63	21.588	−112.206	−13.817	1.00	48.31	N
ATOM	401	CA	PRO	A	63	22.335	−111.925	−12.595	1.00	45.27	C
ATOM	402	CB	PRO	A	63	23.221	−113.164	−12.434	1.00	50.06	C
ATOM	403	CG	PRO	A	63	22.494	−114.251	−13.169	1.00	51.29	C
ATOM	404	CD	PRO	A	63	21.843	−113.567	−14.331	1.00	49.24	C
ATOM	405	C	PRO	A	63	23.178	−110.678	−12.752	1.00	40.97	C
ATOM	406	O	PRO	A	63	23.586	−116.350	−13.864	1.00	41.78	O
ATOM	407	N	GLY	A	64	23.415	−109.989	−11.640	1.00	40.12	N
ATOM	408	CA	GLY	A	64	24.140	−108.708	−11.606	1.00	39.07	C
ATOM	409	C	GLY	A	64	25.629	−108.968	−11.513	1.00	39.76	C
ATOM	410	O	GLY	A	64	26.037	−116.106	−11.645	1.00	38.55	O
ATOM	411	N	PRO	A	65	26.455	−107.919	−11.290	1.00	42.20	N
ATOM	412	CA	PRO	A	65	26.094	−106.494	−11.098	1.00	40.32	C
ATOM	413	CB	PRO	A	65	27.435	−105.841	−10.730	1.00	42.83	C
ATOM	414	CG	PRO	A	65	28.479	−106.732	−11.332	1.00	39.26	C
ATOM	415	CD	PRO	A	65	27.921	−108.129	−11.253	1.00	37.51	C
ATOM	416	C	PRO	A	65	25.535	−105.844	−12.375	1.00	43.31	C
ATOM	417	O	PRO	A	65	25.979	−106.169	−13.478	1.00	44.09	O
ATOM	418	N	GLN	A	66	24.587	−104.925	−12.226	1.00	43.24	N
ATOM	419	CA	GLN	A	66	24.001	−104.244	−13.373	1.00	40.88	C
ATOM	420	CB	GLN	A	66	22.663	−103.591	−13.016	1.00	37.29	C
ATOM	421	CG	GLN	A	66	21.553	−104.555	−12.622	1.00	36.54	C
ATOM	422	CD	GLN	A	66	21.356	−105.711	−13.586	1.00	39.92	C
ATOM	423	CE1	GLN	A	66	21.351	−105.535	−14.807	1.00	39.83	O
ATOM	424	NE2	GLN	A	66	21.176	−106.922	−13.029	1.00	40.52	N
ATOM	425	C	GLN	A	66	24.961	−103.226	−13.970	1.00	42.27	C
ATOM	426	C	GLN	A	66	24.842	−102.879	−15.151	1.00	43.99	O
ATOM	427	N	THR	A	67	25.907	−102.748	−13.156	1.00	38.70	N
ATOM	428	CA	THR	A	67	26.984	−101.888	−13.651	1.00	37.43	C
ATOM	429	CB	THR	A	67	26.519	−100.438	−13.891	1.00	40.35	C
ATOM	430	CG1	THR	A	67	27.584	−99.687	−14.482	1.00	40.53	O
ATOM	431	CG2	THR	A	67	26.118	−99.756	−12.571	1.00	41.63	C
ATOM	432	C	THR	A	67	28.194	−101.672	−12.725	1.00	37.85	C
ATOM	433	O	THR	A	67	28.264	−102.603	−11.753	1.00	40.39	O
ATOM	434	N	ARG	A	68	29.123	−100.995	−13.043	1.00	38.59	N
ATOM	435	CA	ARG	A	68	30.343	−100.783	−12.302	1.00	43.86	C
ATOM	436	CB	ARG	A	68	31.367	−100.163	−13.267	1.00	46.57	C
ATOM	437	CG	ARG	A	68	32.113	−98.921	−12.837	1.00	53.83	C
ATOM	438	CD	ARG	A	68	32.735	−98.243	−14.056	1.00	55.50	C
ATOM	439	NE	ARG	A	68	33.449	−99.189	−14.918	1.00	53.04	N
ATOM	440	CZ	ARG	A	68	33.776	−98.965	−16.190	1.00	55.82	C
ATOM	441	NH1	ARG	A	68	33.447	−97.823	−16.790	1.00	55.96	N
ATOM	442	NH2	ARG	A	68	34.424	−99.901	−16.876	1.00	56.06	N
ATOM	443	C	ARG	A	68	30.108	−99.955	−11.032	1.00	46.99	C
ATOM	444	O	ARG	A	68	29.296	−99.029	−11.003	1.00	51.17	O
ATOM	445	N	SER	A	69	30.857	−100.301	−9.995	1.00	47.24	N
ATOM	446	CA	SER	A	69	30.616	−99.870	−8.635	1.00	44.29	C
ATOM	447	CB	SER	A	69	31.395	−100.816	−7.702	1.00	42.30	C
ATOM	448	OG	SER	A	69	31.424	−100.376	−6.360	1.00	42.69	O
ATOM	449	C	SER	A	69	30.956	−98.398	−8.356	1.00	46.48	C
ATOM	450	O	SER	A	69	31.976	−97.849	−8.902	1.00	45.39	O
ATOM	451	N	ASP	A	70	30.144	−97.765	−7.505	1.00	46.29	N
ATOM	452	CA	ASP	A	70	30.430	−96.400	−7.012	1.00	46.65	C
ATOM	453	CB	ASP	A	70	29.279	−95.836	−6.165	1.00	45.40	C
ATOM	454	CG	ASP	A	70	28.906	−96.711	−4.964	1.00	47.56	C
ATOM	455	OD1	ASP	A	70	29.068	−97.955	−5.004	1.00	48.85	O
ATOM	456	OD2	ASP	A	70	28.408	−96.133	−3.969	1.00	47.88	O
ATOM	457	C	ASP	A	70	31.735	−96.273	−6.234	1.00	44.54	C
ATOM	458	O	ASP	A	70	32.321	−95.184	−6.160	1.00	44.00	O
ATOM	459	N	LEU	A	71	32.204	−97.381	−5.670	1.00	44.27	N
ATOM	460	CA	LEU	A	71	33.440	−97.332	−4.875	1.00	44.84	C
ATOM	461	CB	LEU	A	71	33.676	−98.641	−4.131	1.00	44.06	C
ATOM	462	CG	LEU	A	71	32.683	−98.903	−2.994	1.00	44.10	C
ATOM	463	CD1	LEU	A	71	32.843	−100.317	−2.434	1.00	41.56	C
ATOM	464	CD2	LEU	A	71	32.822	−97.861	−1.888	1.00	42.69	C
ATOM	465	C	LEU	A	71	34.655	−96.938	−5.696	1.00	42.04	C
ATOM	466	O	LEU	A	71	35.623	−96.417	−5.154	1.00	43.82	O
ATOM	467	N	LEU	A	72	34.561	−97.133	−7.011	1.00	44.56	N
ATOM	468	CA	LEU	A	72	35.649	−96.875	−7.951	1.00	40.67	C
ATOM	469	CB	LEU	A	72	35.302	−97.365	−9.339	1.00	38.29	C
ATOM	470	CG	LEU	A	72	35.401	−98.875	−3.481	1.00	40.04	C
ATOM	471	CD1	LEU	A	72	34.797	−99.311	−10.811	1.00	41.21	C
ATOM	472	CD2	LEU	A	72	36.870	−99.297	−9.374	1.00	42.71	C
ATOM	473	C	LEU	A	72	36.116	−95.443	−8.017	1.00	43.86	C
ATOM	474	O	LEU	A	72	37.216	−95.184	−8.512	1.00	48.77	O
ATOM	475	N	LEU	A	73	35.314	−94.514	−7.504	1.00	44.68	N
ATOM	476	CA	LEU	A	73	35.743	−93.115	−7.381	1.00	44.86	C
ATOM	477	CB	LEU	A	73	33.128	−92.247	−8.478	1.00	44.24	C
ATOM	478	CG	LEU	A	73	35.469	−92.407	−9.959	1.00	45.34	C
ATOM	479	CD1	LEU	A	73	34.686	−91.367	−10.772	1.00	39.88	C
ATOM	480	CD2	LEU	A	73	36.975	−92.240	−10.171	1.00	43.21	C
ATOM	481	C	LEU	A	73	33.361	−92.533	−6.034	1.00	47.18	C
ATOM	482	O	LEU	A	73	34.381	−92.972	−5.408	1.00	49.64	O
ATOM	483	N	SER	A	74	36.138	−91.547	−5.592	1.00	46.28	N
ATOM	484	CA	SER	A	74	33.748	−90.716	−4.461	1.00	47.78	C
ATOM	485	CB	SER	A	74	36.853	−89.699	−4.130	1.00	46.92	C
ATOM	486	OG	SER	A	74	36.930	−88.652	−5.090	1.00	45.43	O
ATOM	487	C	SER	A	74	34.428	−89.970	−4.713	1.00	49.61	C
ATOM	488	O	SER	A	74	34.094	−89.596	−5.848	1.00	48.53	O
ATOM	489	N	GLY	A	75	33.696	−89.742	−3.633	1.00	52.56	N
ATOM	490	CA	GLY	A	75	32.548	−88.849	−3.655	1.00	51.82	C
ATOM	491	C	GLY	A	75	32.866	−87.556	−4.367	1.00	51.97	C
ATOM	492	O	GLY	A	75	32.105	−87.130	−5.225	1.00	51.94	O
ATOM	493	N	ARG	A	76	34.006	−86.944	−4.041	1.00	54.06	N
ATOM	494	CA	ARG	A	76	34.371	−85.582	−4.672	1.00	53.09	C
ATOM	495	CB	ARG	A	76	35.629	−85.344	−4.065	1.00	57.69	C
ATOM	496	CG	ARG	A	76	36.165	−83.914	−4.952	1.00	65.78	C
ATOM	497	CD	ARG	A	76	37.274	−83.357	−4.363	1.00	71.53	C
ATOM	498	NE	ARG	A	76	36.915	−82.406	−3.097	1.00	82.09	N
ATOM	499	CZ	ARG	A	76	35.916	−81.537	−2.915	1.00	84.58	C
ATOM	500	NH1	ARG	A	76	35.098	−81.193	−3.909	1.00	83.53	C
ATOM	501	NH2	ARG	A	76	35.724	−81.924	−1.705	1.00	86.27	N
ATOM	502	C	ARG	A	76	34.539	−85.832	−6.178	1.00	52.74	C
ATOM	503	O	ARG	A	76	34.113	−84.956	−6.930	1.00	55.31	O
ATOM	504	N	ASP	A	77	35.154	−86.928	−6.616	1.00	49.27	N
ATOM	505	CA	ASP	A	77	35.384	−87.143	−8.048	1.00	48.71	C
ATOM	506	CB	ASP	A	77	36.310	−88.348	−8.296	1.00	47.87	C
ATOM	507	CG	ASP	A	77	37.810	−88.317	−8.072	1.00	52.71	C
ATOM	508	OD1	ASP	A	77	38.182	−86.837	−7.865	1.00	54.74	O
ATOM	509	OD2	ASP	A	77	38.628	−88.956	−8.105	1.00	50.81	O
ATOM	510	C	ASP	A	77	34.058	−87.299	−8.811	1.00	45.07	C
ATOM	511	O	ASP	A	77	33.892	−86.777	−9.930	1.00	42.37	O
ATOM	512	N	TRP	A	78	33.122	−88.010	−8.196	1.00	39.30	N
ATOM	513	CA	TRP	A	78	31.804	−88.172	−8.768	1.00	39.03	C
ATOM	514	CB	TRP	A	78	30.986	−89.145	−7.931	1.00	37.92	C
ATOM	515	CG	TRP	A	78	31.330	−90.623	−8.072	1.00	40.66	C
ATOM	516	CD1	TRP	A	78	31.738	−91.464	−7.071	1.00	40.56	C
ATOM	517	NE1	TRP	A	78	31.922	−92.747	−7.559	1.00	40.28	N
ATOM	518	CE2	TRP	A	78	31.636	−92.759	−8.901	1.00	40.56	C
ATOM	519	CD2	TRP	A	78	31.258	−91.440	−9.268	1.00	42.84	C
ATOM	520	CE3	TRP	A	78	30.917	−91.185	−10.606	1.00	41.86	C
ATOM	521	CZ3	TRP	A	78	30.965	−92.248	−11.526	1.00	41.10	C
ATOM	522	CH2	TRP	A	78	31.329	−93.545	−11.121	1.00	39.77	C
ATOM	523	CZ2	TRP	A	78	31.670	−93.818	−9.819	1.00	39.05	C
ATOM	524	C	TRP	A	78	31.089	−86.307	−8.867	1.00	41.09	C
ATOM	525	O	TRP	A	78	30.591	−86.447	−9.928	1.00	42.27	O
ATOM	526	N	ASN	A	79	31.075	−86.049	−7.771	1.00	40.49	N
ATOM	527	CA	ASN	A	79	30.484	−84.718	−7.724	1.00	41.29	C
ATOM	528	CB	ASN	A	79	30.723	−84.089	−6.354	1.00	43.43	C
ATOM	529	CG	ASN	A	79	29.917	−84.729	−5.258	1.00	46.48	C
ATOM	530	CD1	ASN	A	79	29.054	−85.588	−5.499	1.00	45.62	O
ATOM	531	ND2	ASN	A	79	30.197	−84.309	−4.022	1.00	47.42	N
ATOM	532	C	ASN	A	79	31.029	−83.710	−8.725	1.00	43.97	C
ATOM	533	O	ASN	A	79	30.357	−82.722	−9.044	1.00	46.17	O
ATOM	534	N	THR	A	80	32.255	−83.906	−9.189	1.00	44.16	N
ATOM	535	CA	THR	A	80	32.928	−82.810	−9.893	1.00	45.69	C
ATOM	536	CB	THR	A	80	34.016	−82.135	−9.025	1.00	44.75	C
ATOM	537	OG1	THR	A	80	34.817	−83.136	−8.400	1.00	48.06	O
ATOM	538	OG2	THR	A	80	33.398	−81.215	−7.953	1.00	42.20	C
ATOM	539	C	THR	A	80	33.552	−83.168	−11.225	1.00	44.18	C
ATOM	540	O	THR	A	80	33.728	−82.305	−12.082	1.00	45.43	O
ATOM	541	N	LEU	A	81	33.883	−84.431	−11.413	1.00	45.35	N
ATOM	542	CA	LEU	A	81	34.601	−84.792	−12.621	1.00	49.41	C
ATOM	543	CB	LEU	A	81	35.901	−85.554	−12.278	1.00	53.74	C
ATOM	544	CG	LEU	A	81	36.872	−84.910	−11.264	1.00	52.94	C
ATOM	545	CD1	LEU	A	81	38.085	−85.808	−11.079	1.00	57.04	C
ATOM	546	CD2	LEU	A	81	37.300	−83.495	−11.648	1.00	49.48	C
ATOM	547	C	LEU	A	81	33.761	−85.530	−13.664	1.00	49.12	C
ATOM	548	O	LEU	A	81	34.169	−85.630	−14.818	1.00	55.36	O
ATOM	549	N	ILE	A	82	32.589	−86.021	−13.272	1.00	44.77	N
ATOM	550	CA	ILE	A	82	31.809	−86.916	−14.134	1.00	43.01	C
ATOM	551	CB	ILE	A	82	31.584	−88.271	−13.446	1.00	40.95	C
ATOM	552	CG1	ILE	A	82	37.917	−88.826	−12.935	1.00	42.22	C
ATOM	553	CD1	ILE	A	82	33.831	−89.396	−14.004	1.00	37.64	C
ATOM	554	CG2	ILE	A	82	30.850	−89.243	−14.373	1.00	38.24	C
ATOM	555	C	ILE	A	82	30.444	−86.379	−14.571	1.00	43.39	C
ATOM	556	O	ILE	A	82	29.647	−85.915	−13.765	1.00	45.91	O
ATOM	557	N	VAL	A	83	30.190	−86.477	−15.864	1.00	44.03	N
ATOM	558	CA	VAL	A	83	28.899	−86.187	−16.442	1.00	41.06	C
ATOM	559	CB	VAL	A	83	29.031	−85.121	−17.545	1.00	40.83	C
ATOM	560	CG1	VAL	A	83	27.765	−85.043	−18.385	1.00	41.55	C
ATOM	561	CG2	VAL	A	83	29.373	−83.764	−16.932	1.00	38.24	C
ATOM	562	C	VAL	A	83	28.392	−87.491	−17.020	1.00	39.55	C
ATOM	563	O	VAL	A	83	29.057	−88.093	−17.870	1.00	40.68	O
ATOM	564	N	GLY	A	84	27.231	−87.938	−16.538	1.00	39.83	N
ATOM	565	CA	GLY	A	84	26.572	−89.146	−17.047	1.00	35.63	C
ATOM	566	C	GLY	A	84	26.041	−88.982	−18.469	1.00	34.98	C
ATOM	567	O	GLY	A	84	25.905	−87.870	−18.968	1.00	34.30	O
ATOM	568	N	LYS	A	85	25.747	−90.102	−19.122	1.00	37.85	N
ATOM	569	CA	LYS	A	85	25.154	−90.105	−20.457	1.00	40.47	C
ATOM	570	CB	LYS	A	85	26.172	−90.471	−21.535	1.00	39.59	C
ATOM	571	CG	LYS	A	85	27.344	−89.521	−21.677	1.00	44.46	C
ATOM	572	CD	LYS	A	85	28.407	−90.096	−22.610	1.00	42.32	C
ATOM	573	CE	LYS	A	85	28.196	−89.688	−24.052	1.00	45.28	C
ATOM	574	NZ	LYS	A	85	28.747	−90.699	−24.993	1.00	53.62	N
ATOM	575	C	LYS	A	85	24.096	−91.178	−20.443	1.00	41.45	C
ATOM	576	O	LYS	A	85	24.342	−92.282	−19.962	1.00	39.06	O
ATOM	577	N	LEU	A	86	22.920	−90.854	−20.975	1.00	40.31	N
ATOM	578	CA	LEU	A	86	21.870	−91.863	−21.139	1.00	39.24	C
ATOM	579	CB	LEU	A	86	20.569	−91.200	−21.624	1.00	34.16	C
ATOM	580	CG	LEU	A	86	19.352	−92.117	−21.721	1.00	35.27	C
ATOM	581	CD1	LEU	A	86	18.907	−92.488	−20.312	1.00	33.98	C
ATOM	582	CD2	LEU	A	86	18.221	−91.466	−22.517	1.00	35.22	C
ATOM	583	C	LEU	A	86	22.332	−92.944	−22.140	1.00	39.95	C
ATOM	584	O	LEU	A	86	22.945	−92.636	−23.156	1.00	37.07	O
ATOM	585	N	SER	A	87	22.036	−94.205	−21.864	1.00	39.36	N
ATOM	586	CA	SER	A	87	22.379	−95.258	−22.815	1.00	41.04	C
ATOM	587	CB	SER	A	87	22.128	−96.622	−22.202	1.00	39.59	C
ATOM	588	OG	SER	A	87	23.009	−96.816	−21.114	1.00	44.82	O
ATOM	589	C	SER	A	87	21.638	−95.104	−24.153	1.00	43.52	C
ATOM	590	O	SER	A	87	20.433	−94.860	−24.187	1.00	50.28	O
ATOM	591	N	PRO	A	88	22.358	−95.282	−25.263	1.00	43.27	N
ATOM	592	CA	PRO	A	88	21.841	−94.836	−26.540	1.00	40.91	C
ATOM	593	CB	PRO	A	88	23.072	−94.890	−27.437	1.00	41.29	C
ATOM	594	CG	PRO	A	88	23.812	−96.076	−26.912	1.00	44.51	C
ATOM	595	CD	PRO	A	88	23.627	−96.026	−25.417	1.00	43.40	C
ATOM	596	C	PRO	A	88	20.769	−95.729	−27.108	1.00	37.53	C
ATOM	597	O	PRO	A	88	20.233	−95.385	−28.136	1.00	39.86	O
ATOM	598	N	TRP	A	89	20.486	−96.858	−26.456	1.00	34.83	N
ATOM	599	CA	TRP	A	89	19.426	−97.771	−26.858	1.00	32.45	C
ATOM	600	CB	TRP	A	89	19.767	−99.224	−26.501	1.00	32.12	C
ATOM	601	CG	TRP	A	89	20.030	−99.498	−25.007	1.00	33.71	C
ATOM	602	CD1	TRP	A	89	21.243	−99.414	−24.351	1.00	34.05	C
ATOM	603	NE1	TRP	A	89	21.080	−99.741	−23.021	1.00	34.80	N
ATOM	604	CE2	TRP	A	89	19.767	−100.056	−22.795	1.00	31.01	C
ATOM	605	CD2	TRP	A	89	19.076	−99.923	−24.019	1.00	31.97	C
ATOM	606	CE3	TRP	A	89	17.686	−100.168	−24.043	1.00	32.69	C
ATOM	607	CZ3	TRP	A	89	17.047	−100.554	−22.870	1.00	29.34	C
ATOM	608	CH2	TRP	A	89	17.759	−100.680	−21.667	1.00	30.46	C
ATOM	609	CZ2	TRP	A	89	19.123	−100.432	−21.610	1.00	34.97	C
ATOM	610	C	TRP	A	89	18.104	−97.425	−26.184	1.00	37.08	C
ATOM	611	O	TRP	A	89	17.063	−98.012	−26.501	1.00	34.83	O
ATOM	612	N	ILE	A	90	18.165	−96.524	−25.205	1.00	38.04	N
ATOM	613	CA	ILE	A	90	16.992	−96.133	−24.467	1.00	38.01	C
ATOM	614	CB	ILE	A	90	17.374	−95.467	−23.136	1.00	40.38	C
ATOM	615	CG1	ILE	A	90	18.017	−96.516	−22.202	1.00	35.71	C
ATOM	616	CD1	ILE	A	90	18.817	−95.924	−21.073	1.00	32.82	C
ATOM	617	CG2	ILE	A	90	16.148	−94.795	−22.506	1.00	36.71	C
ATOM	618	C	ILE	A	90	16.200	−95.214	−25.370	1.00	38.75	C
ATOM	619	O	ILE	A	90	16.682	−94.148	−25.740	1.00	38.81	O
ATOM	620	N	ARG	A	91	15.018	−95.572	−25.779	1.00	35.36	N
ATOM	621	CA	ARG	A	91	14.181	−94.335	−26.725	1.00	35.49	C
ATOM	622	CB	ARG	A	91	14.214	−95.599	−28.114	1.00	33.88	C
ATOM	623	CG	ARG	A	91	15.538	−95.529	−28.834	1.00	35.61	C
ATOM	624	CD	ARG	A	91	15.761	−94.206	−29.550	1.00	38.15	C
ATOM	625	NE	ARG	A	91	16.108	−93.140	−28.615	1.00	42.99	N
ATOM	626	CZ	ARG	A	91	16.223	−91.248	−28.936	1.00	44.08	C
ATOM	627	NH1	ARG	A	91	16.531	−90.261	−27.992	1.00	38.62	N
ATOM	628	NH2	ARG	A	91	16.038	−91.437	−30.195	1.00	45.66	N
ATOM	629	C	ARG	A	91	12.738	−94.367	−26.191	1.00	36.06	C
ATOM	630	O	ARG	A	91	11.879	−95.592	−26.551	1.00	31.97	O
ATOM	631	N	PRO	A	92	12.471	−93.393	−25.307	1.00	35.78	N
ATOM	632	CA	PRO	A	92	11.159	−93.306	−24.628	1.00	34.77	C
ATOM	633	CB	PRO	A	92	11.347	−92.556	−23.633	1.00	36.52	C
ATOM	634	CG	PRO	A	92	12.824	−92.374	−23.586	1.00	36.21	C
ATOM	635	CD	PRO	A	92	13.427	−92.466	−24.859	1.00	31.95	C
ATOM	636	C	PRO	A	92	10.014	−93.484	−25.586	1.00	36.06	C
ATOM	637	O	PRO	A	92	8.829	−93.640	−25.244	1.00	40.20	O
ATOM	638	N	ASP	A	93	10.365	−93.648	−26.784	1.00	36.61	N
ATOM	639	CA	ASP	A	93	9.388	−92.602	−27.759	1.00	34.98	C
ATOM	640	CB	ASP	A	93	9.639	−91.152	−28.108	1.00	33.74	C
ATOM	641	CG	ASP	A	93	9.159	−90.245	−27.019	1.00	36.52	C
ATOM	642	OD1	ASP	A	93	7.899	−90.083	−26.895	1.00	34.93	O
ATOM	643	OD2	ASP	A	93	10.031	−89.751	−26.255	1.00	32.77	O
ATOM	644	C	ASP	A	93	9.357	−93.459	−28.990	1.00	35.92	C
ATOM	645	O	ASP	A	93	8.950	−93.018	−30.055	1.00	38.67	O
ATOM	646	N	SER	A	94	9.804	−94.696	−28.834	1.00	37.95	N
ATOM	647	CA	SER	A	94	9.739	−95.673	−79.899	1.00	36.54	C
ATOM	648	CB	SER	A	94	10.580	−96.879	−29.498	1.00	37.89	C
ATOM	649	OG	SER	A	94	9.987	−98.105	−29.871	1.00	39.43	O
ATOM	650	C	SER	A	94	8.284	−96.080	−30.124	1.00	37.15	C
ATOM	651	O	SER	A	94	7.449	−95.963	−29.231	1.00	32.73	O
ATOM	652	N	LYS	A	95	8.013	−96.579	−31.318	1.00	41.15	N
ATOM	653	CA	LYS	A	95	6.674	−96.964	−31.721	1.00	46.86	C
ATOM	654	CB	LYS	A	95	6.537	−96.870	−33.256	1.00	54.28	C
ATOM	655	CG	LYS	A	95	7.113	−95.610	−33.906	1.00	60.72	C
ATOM	656	CD	LYS	A	95	6.031	−94.712	−34.501	1.00	62.96	C
ATOM	657	CE	LYS	A	95	5.228	−93.984	−33.434	1.00	64.26	C
ATOM	658	NZ	LYS	A	95	5.874	−92.709	−33.010	1.00	64.44	N
ATOM	659	C	LYS	A	95	6.384	−98.387	−31.288	1.00	44.83	C
ATOM	660	O	LYS	A	95	5.285	−98.886	−31.511	1.00	43.96	O
ATOM	661	N	VAL	A	96	7.377	−99.061	−30.713	1.00	41.51	N
ATOM	662	CA	VAL	A	96	7.194	−100.443	−30.294	1.00	40.98	C
ATOM	663	CB	VAL	A	96	8.422	−101.327	−30.641	1.00	44.98	C
ATOM	664	CG1	VAL	A	96	8.317	−102.707	−30.003	1.00	42.48	C
ATOM	665	CG2	VAL	A	96	8.582	−101.472	−32.145	1.00	45.47	C
ATOM	666	C	VAL	A	96	6.990	−100.422	−28.802	1.00	41.68	C
ATOM	667	O	VAL	A	96	7.878	−99.973	−28.059	1.00	41.02	O
ATOM	668	N	GLU	A	97	5.840	−100.924	−28.359	1.00	41.87	N
ATOM	669	CA	GLU	A	97	5.487	−100.855	−26.945	1.00	44.03	C
ATOM	670	CB	GLU	A	97	4.084	−101.387	−26.682	1.00	45.55	C
ATOM	671	CG	GLU	A	97	3.562	−100.911	−25.341	1.00	50.55	C
ATOM	672	CD	GLU	A	97	2.437	−101.760	−24.807	1.00	55.62	C
ATOM	673	OE1	GLU	A	97	1.289	−101.606	−25.283	1.00	59.54	O
ATOM	674	OE2	GLU	A	97	2.710	−102.574	−23.900	1.00	57.62	O
ATOM	675	C	GLU	A	97	6.503	−101.491	−23.976	1.00	42.67	C
ATOM	676	O	GLU	A	97	6.834	−100.887	−24.932	1.00	42.88	O
ATOM	677	N	LYS	A	98	7.010	−102.676	−26.311	1.00	39.77	N
ATOM	678	CA	LYS	A	98	7.949	−103.351	−25.404	1.00	40.70	C
ATOM	679	CB	LYS	A	98	8.251	−104.779	−25.847	1.00	43.84	C
ATOM	680	CG	LYS	A	98	7.194	−105.829	−25.546	1.00	44.99	C
ATOM	681	CD	LYS	A	98	7.249	−106.884	−26.650	1.00	50.67	C
ATOM	682	CE	LYS	A	98	6.555	−108.190	−26.278	1.00	56.41	C
ATOM	683	NZ	LYS	A	98	7.520	−109.242	−25.830	1.00	58.24	N
ATOM	684	C	LYS	A	98	0.241	−102.550	−75.237	1.00	38.72	C
ATOM	685	O	LYS	A	98	9.797	−102.501	−24.136	1.00	42.48	O
ATOM	686	N	ILE	A	99	9.678	−101.902	−26.314	1.00	37.90	N
ATOM	687	CA	ILE	A	99	10.875	−101.039	−26.311	1.00	38.53	C
ATOM	688	CB	ILE	A	99	11.319	−100.724	−27.756	1.00	39.11	C
ATOM	689	CG1	ILE	A	99	11.736	−102.021	−28.467	1.00	38.03	C
ATOM	690	CD1	ILE	A	99	12.222	−101.807	−29.890	1.00	40.05	C
ATOM	691	CG2	ILE	A	99	12.431	−99.660	−27.794	1.00	38.22	C
ATOM	692	C	ILE	A	99	10.646	−99.745	−25.528	1.00	39.33	C
ATOM	693	O	ILE	A	99	11.519	−99.266	−24.787	1.00	36.71	O
ATOM	694	N	ARG	A	100	9.462	−99.175	−25.715	1.00	41.43	N
ATOM	695	CA	ARG	A	100	9.040	−98.017	−24.956	1.00	42.09	C
ATOM	696	CB	ARG	A	100	7.658	−97.608	−25.439	1.00	48.15	C
ATOM	697	CG	ARG	A	100	7.059	−96.371	−24.812	1.00	51.56	C
ATOM	698	CD	ARG	A	100	5.982	−95.818	−25.743	1.00	61.56	C
ATOM	699	NE	ARG	A	100	4.813	−96.699	−25.920	1.00	58.61	N
ATOM	700	CZ	ARG	A	100	4.338	−97.100	−27.108	1.00	63.98	C
ATOM	701	NH1	ARG	A	100	4.915	−96.716	−28.243	1.00	53.50	N
ATOM	702	NH2	ARG	A	100	3.264	−97.888	−27.167	1.00	65.09	N
ATOM	703	C	ARG	A	100	9.071	−98.322	−23.445	1.00	40.87	C
ATOM	704	O	ARG	A	100	9.643	−97.558	−22.687	1.00	39.83	O
ATOM	705	N	ARG	A	101	8.491	−99.448	−23.017	1.00	42.13	N
ATOM	706	CA	ARG	A	101	8.453	−99.804	−21.590	1.00	41.92	C
ATOM	707	CB	ARG	A	101	7.515	−100.983	−21.333	1.00	46.37	C
ATOM	708	CG	ARG	A	101	6.037	−100.681	−21.553	1.00	61.06	C
ATOM	709	CD	ARG	A	101	5.142	−101.762	−20.955	1.00	68.14	C
ATOM	710	NE	ARG	A	101	3.735	−101.620	−21.350	1.00	78.37	N
ATOM	711	CZ	ARG	A	101	2.836	−100.872	−20.708	1.00	85.80	C
ATOM	712	NH1	ARG	A	101	3.182	−100.179	−19.630	1.00	97.56	N
ATOM	713	NH2	ARG	A	101	1.583	−100.813	−21.139	1.00	81.70	N
ATOM	714	C	ARG	A	101	9.845	−100.079	−20.994	1.00	40.29	C
ATOM	715	O	ARG	A	101	10.193	−99.547	−19.931	1.00	39.67	O
ATOM	716	N	ASN	A	102	10.639	−100.915	−21.652	1.00	38.95	N
ATOM	717	CA	ASN	A	102	12.017	−101.114	−21.182	1.00	41.26	C
ATOM	718	CB	ASN	A	102	12.797	−102.128	−22.037	1.00	39.54	C
ATOM	719	CG	ASN	A	102	12.515	−103.573	−21.645	1.00	41.28	C
ATOM	720	OD1	ASN	A	102	12.324	−103.891	−20.468	1.00	42.16	O
ATOM	721	ND2	ASN	A	102	12.489	−104.463	−22.642	1.00	41.63	N
ATOM	722	C	ASN	A	102	12.758	−99.791	−21.135	1.00	37.16	C
ATOM	723	O	ASN	A	102	13.525	−99.533	−20.222	1.00	36.77	O
ATOM	724	N	SER	A	103	12.487	−98.931	−22.105	1.00	37.18	N
ATOM	725	CA	SER	A	103	13.192	−97.668	−22.157	1.00	35.70	C
ATOM	726	CB	SER	A	103	13.048	−97.359	−23.533	1.00	34.71	C
ATOM	727	OG	SER	A	103	13.812	−97.803	−24.473	1.00	31.90	O
ATOM	728	C	SER	A	103	12.803	−96.723	−20.995	1.00	36.30	C
ATOM	729	O	SER	A	103	13.681	−96.128	−20.357	1.00	33.48	O
ATOM	730	N	GLU	A	104	11.507	−96.523	−20.694	1.00	34.19	N
ATOM	731	CA	GLU	A	104	11.057	−95.891	−19.518	1.00	36.87	C
ATOM	732	CB	GLU	A	104	9.532	−96.048	−19.315	1.00	38.53	C
ATOM	733	CG	GLU	A	104	8.707	−95.451	−20.463	1.00	44.48	C
ATOM	734	CD	GLU	A	104	7.258	−95.945	−20.549	1.00	48.42	C
ATOM	735	OE1	GLU	A	104	6.828	−96.744	−19.681	1.00	54.54	O
ATOM	736	OE2	GLU	A	104	6.537	−95.331	−21.493	1.00	45.55	O
ATOM	737	C	GLU	A	104	11.832	−96.385	−18.289	1.00	35.25	C
ATOM	738	O	GLU	A	104	12.542	−95.515	−17.639	1.00	34.79	O
ATOM	739	N	ALA	A	105	11.712	−97.575	−17.994	1.00	34.67	N
ATOM	740	CA	ALA	A	105	12.370	−98.271	−16.825	1.00	35.31	C
ATOM	741	CB	ALA	A	105	12.033	−99.741	−16.724	1.00	33.70	C
ATOM	742	C	ALA	A	105	13.896	−98.075	−16.818	1.00	35.90	C
ATOM	743	O	ALA	A	105	14.494	−97.797	−15.757	1.00	37.05	O
ATOM	744	N	ALA	A	106	14.508	−98.177	−17.991	1.00	34.89	N
ATOM	745	CA	ALA	A	106	15.968	−98.049	−18.122	1.00	38.39	C
ATOM	746	CB	ALA	A	106	16.408	−98.494	−19.498	1.00	36.28	C
ATOM	747	C	ALA	A	106	16.424	−91.627	−17.855	1.00	38.51	C
ATOM	748	O	ALA	A	106	17.463	−96.397	−17.223	1.00	42.37	O
ATOM	749	N	MET	A	107	15.626	−95.679	−18.339	1.00	41.19	N
ATOM	750	CA	MET	A	107	15.883	−94.255	−18.180	1.00	39.68	C
ATOM	751	CB	MET	A	107	14.906	−93.434	−19.018	1.00	40.19	C
ATOM	752	CG	MET	A	107	15.084	−91.938	−18.879	1.00	35.92	C
ATOM	753	SD	MET	A	107	14.091	−91.038	−20.097	1.00	40.74	S
ATOM	754	CE	MET	A	107	14.389	−89.351	−19.582	1.00	30.33	C
ATOM	755	C	MET	A	107	15.766	−93.884	−16.711	1.00	39.51	C
ATOM	756	O	MET	A	107	16.668	−93.265	−16.164	1.00	42.04	O
ATOM	757	N	LEU	A	108	14.676	−94.282	−16.063	1.00	37.72	N
ATOM	758	CA	LEU	A	108	14.581	−94.085	−14.626	1.00	38.47	C
ATOM	759	CB	LEU	A	108	13.331	−94.755	−14.061	1.00	41.60	C
ATOM	760	CG	LEU	A	108	12.011	−94.031	−14.310	1.00	48.35	C
ATOM	761	CD1	LEU	A	108	10.871	−94.778	−13.637	1.00	48.81	C
ATOM	762	CD2	LEU	A	108	12.094	−92.581	−13.820	1.00	50.82	C
ATOM	763	C	LEU	A	108	15.829	−94.627	−13.921	1.00	37.54	C
ATOM	764	O	LEU	A	108	16.444	−93.932	−13.092	1.00	36.14	O
ATOM	765	N	GLN	A	109	16.180	−95.871	−14.247	1.00	36.85	N
ATOM	766	CA	GLN	A	109	17.292	−96.548	−13.617	1.00	34.97	C
ATOM	767	CB	GLN	A	109	17.431	−97.461	−14.152	1.00	38.58	C
ATOM	768	CG	GLN	A	109	18.616	−98.193	−13.601	1.00	36.97	C
ATOM	769	CD	GLN	A	109	18.767	−100.083	−14.385	1.00	36.96	C
ATOM	770	OE1	GLN	A	109	18.719	−100.072	−15.626	1.00	39.41	O
ATOM	771	NE2	GLN	A	109	18.903	−101.200	−13.687	1.00	36.66	N
ATOM	772	C	GLN	A	109	18.570	−95.254	−13.814	1.00	34.43	C
ATOM	773	O	GLN	A	109	19.252	−95.459	−12.843	1.00	33.78	O
ATOM	774	N	GLU	A	110	18.875	−95.336	−15.039	1.00	33.35	N
ATOM	775	CA	GLU	A	110	20.137	−94.624	−15.194	1.00	37.62	C
ATOM	776	CB	GLU	A	110	20.603	−94.539	−16.653	1.00	40.85	C
ATOM	777	CG	GLU	A	110	20.729	−95.901	−17.297	1.00	37.13	C
ATOM	778	CD	GLU	A	110	21.377	−95.862	−18.651	1.00	37.10	C
ATOM	779	CE1	GLU	A	110	21.675	−96.964	−19.142	1.00	37.48	O
ATOM	780	CE2	GLU	A	110	21.563	−94.769	−19.233	1.00	34.74	O
ATOM	781	C	GLU	A	110	20.071	−93.266	−14.539	1.00	39.10	C
ATOM	782	O	GLU	A	110	21.065	−92.816	−13.951	1.00	43.09	O
ATOM	783	N	LEU	A	111	18.902	−92.626	−14.618	1.00	25.93	N
ATOM	784	CA	LEU	A	111	18.697	−91.352	−13.934	1.00	24.32	C
ATOM	785	CB	LEU	A	111	17.356	−90.711	−14.333	1.00	31.33	C
ATOM	786	CG	LEU	A	111	17.371	−89.994	−15.698	1.00	30.05	C
ATOM	787	CD1	LEU	A	111	15.963	−89.558	−16.042	1.00	28.25	C
ATOM	788	CD2	LEU	A	111	18.317	−88.794	−15.746	1.00	26.52	C
ATOM	789	C	LEU	A	111	18.865	−91.469	−12.406	1.00	34.25	C
ATOM	790	O	LEU	A	111	19.626	−90.719	−11.792	1.00	37.18	O
ATOM	791	N	ASN	A	112	18.183	−92.429	−11.804	1.00	35.40	N
ATOM	792	CA	ASN	A	112	18.372	−92.714	−10.388	1.00	36.06	C
ATOM	793	CB	ASN	A	112	17.444	−93.835	−9.952	1.00	33.87	C
ATOM	794	CG	ASN	A	112	15.986	−93.402	−9.951	1.00	33.88	C
ATOM	795	OD1	ASN	A	112	15.689	−92.216	−9.828	1.00	31.32	O
ATOM	796	ND2	ASN	A	112	15.067	−94.365	−10.088	1.00	34.56	N
ATOM	797	C	ASN	A	112	19.820	−93.002	−9.995	1.00	40.07	C
ATOM	798	O	ASN	A	112	20.274	−92.543	−8.943	1.00	45.80	O
ATOM	799	N	PHE	A	113	20.562	−93.714	−10.843	1.00	37.61	N
ATOM	800	CA	PHE	A	113	21.977	−93.979	−10.553	1.00	37.15	C
ATOM	801	CB	PHE	A	113	22.556	−95.020	−11.530	1.00	33.97	C
ATOM	802	CG	PHE	A	113	23.693	−95.780	−10.959	1.00	37.61	C
ATOM	803	CD1	PHE	A	113	23.493	−96.640	−9.882	1.00	35.43	C
ATOM	804	CE1	PHE	A	113	24.553	−97.337	−9.331	1.00	38.01	C
ATOM	805	CZ	PHE	A	113	25.832	−97.184	−9.846	1.00	36.29	C
ATOM	806	CE2	PHE	A	113	26.046	−96.326	−10.914	1.00	37.24	C
ATOM	807	CD2	PHE	A	113	24.991	−95.622	−11.465	1.00	38.20	C
ATOM	808	C	PHE	A	113	22.818	−92.707	−10.560	1.00	37.25	C
ATOM	809	O	PHE	A	113	23.721	−92.521	−9.742	1.00	40.44	O
ATOM	810	N	GLY	A	114	22.329	−91.808	−11.460	1.00	36.63	N
ATOM	811	CA	GLY	A	114	23.302	−90.574	−11.545	1.00	37.05	C
ATOM	812	C	GLY	A	114	23.113	−89.796	−10.262	1.00	41.70	C
ATOM	813	O	GLY	A	114	24.085	−89.274	−9.678	1.00	46.66	O
ATOM	814	N	ALA	A	115	21.856	−89.729	−9.822	1.00	36.97	N
ATOM	815	CA	ALA	A	115	21.498	−89.038	−8.589	1.00	35.44	C
ATOM	816	CB	ALA	A	115	19.976	−88.918	−8.446	1.00	29.93	C
ATOM	817	C	ALA	A	115	22.107	−89.746	−7.383	1.00	34.76	C
ATOM	818	O	ALA	A	115	22.601	−89.090	−6.463	1.00	36.55	O
ATOM	819	N	TYR	A	116	22.061	−91.079	−7.391	1.00	35.10	N
ATOM	820	CA	TYR	A	116	22.714	−91.876	−6.355	1.00	35.19	C
ATOM	821	CB	TYR	A	116	22.530	−93.362	−6.636	1.00	35.22	C
ATOM	822	CG	TYR	A	116	23.378	−94.287	−5.766	1.00	39.65	C
ATOM	823	CD1	TYR	A	116	22.963	−94.662	−4.486	1.00	38.06	C
ATOM	824	CE1	TYR	A	116	23.725	−95.515	−3.709	1.00	33.94	C
ATOM	825	CZ	TYR	A	116	24.926	−95.987	−4.205	1.00	42.31	C
ATOM	826	OH	TYR	A	116	25.711	−96.837	−3.458	1.00	42.94	O
ATOM	827	CE2	TYR	A	116	25.355	−95.635	−5.473	1.00	40.05	C
ATOM	828	CD2	TYR	A	116	24.586	−94.797	−6.241	1.00	33.49	C
ATOM	829	C	TYR	A	116	24.204	−91.488	−6.246	1.00	35.23	C
ATOM	830	O	TYR	A	116	24.719	−91.303	−5.138	1.00	31.76	O
ATOM	831	N	LEU	A	117	24.853	−91.325	−7.402	1.00	35.21	N
ATOM	832	CA	LEU	A	117	26.280	−90.976	−7.490	1.00	35.40	C
ATOM	833	CB	LEU	A	117	26.849	−91.284	−8.882	1.00	32.32	C
ATOM	834	CG	LEU	A	117	26.848	−92.754	−9.256	1.00	30.92	C
ATOM	835	CD1	LEU	A	117	27.464	−92.960	−10.627	1.00	33.31	C
ATOM	836	CD2	LEU	A	117	27.577	−93.546	−8.191	1.00	25.52	C
ATOM	837	C	LEU	A	117	26.560	−89.537	−7.178	1.00	37.59	C
ATOM	838	O	LEU	A	117	27.648	−89.213	−6.757	1.00	39.30	O
ATOM	839	N	GLY	A	118	25.582	−88.667	−7.413	1.00	40.45	N
ATOM	840	CA	GLY	A	118	25.744	−87.255	−7.117	1.00	35.80	C
ATOM	841	C	GLY	A	118	26.335	−86.527	−8.300	1.00	36.27	C
ATOM	842	O	GLY	A	118	27.003	−85.515	−8.127	1.00	36.75	O
ATOM	843	N	LEU	A	119	26.096	−87.039	−9.507	1.00	33.66	N
ATOM	844	CA	LEU	A	119	26.626	−86.385	−10.701	1.00	32.60	C
ATOM	845	CB	LEU	A	119	26.358	−87.204	−11.965	1.00	30.49	C
ATOM	846	CG	LEU	A	119	26.734	−88.596	−11.885	1.00	30.32	C
ATOM	847	CD1	LEU	A	119	26.392	−89.395	−13.194	1.00	28.65	C
ATOM	848	CD2	LEU	A	119	28.214	−88.388	−11.514	1.00	29.42	C
ATOM	849	C	LEU	A	119	26.046	−84.181	−10.839	1.00	35.76	C
ATOM	850	O	LEU	A	119	24.824	−84.776	−10.622	1.00	35.55	O
ATOM	851	N	PRO	A	120	26.920	−84.112	−11.172	1.00	33.39	N
ATOM	852	CA	PRO	A	120	26.567	−82.614	−11.393	1.00	33.93	C
ATOM	853	CB	PRO	A	120	27.933	−81.928	−11.553	1.00	33.89	C
ATOM	854	CG	PRO	A	120	28.863	−83.023	−11.985	1.00	33.95	C
ATOM	855	CD	PRO	A	120	28.372	−84.252	−11.290	1.00	32.42	C
ATOM	856	C	PRO	A	120	25.749	−82.401	−12.677	1.00	35.76	C
ATOM	857	O	PRO	A	120	25.017	−81.418	−12.796	1.00	37.60	O
ATOM	858	N	ALA	A	121	25.916	−83.282	−13.645	1.00	33.31	N
ATOM	859	CA	ALA	A	121	25.240	−83.150	−14.912	1.00	35.37	C
ATOM	860	CB	ALA	A	121	26.017	−82.232	−15.860	1.00	38.33	C
ATOM	861	C	ALA	A	121	25.068	−84.112	−15.523	1.00	34.51	C
ATOM	862	O	ALA	A	121	25.731	−83.453	−15.136	1.00	36.33	O
ATOM	863	N	PHE	A	122	24.164	−84.802	−16.479	1.00	35.43	N
ATOM	864	CA	PHE	A	122	23.788	−85.161	−17.095	1.00	35.32	C
ATOM	865	CB	PHE	A	122	22.734	−86.151	−16.252	1.00	36.39	C
ATOM	866	CG	PHE	A	122	22.555	−88.010	−16.588	1.00	43.19	C
ATOM	867	CD1	PHE	A	122	21.815	−88.404	−17.717	1.00	44.17	C
ATOM	868	CE1	PHE	A	122	21.640	−89.742	−18.023	1.00	42.80	C
ATOM	869	CZ	PHE	A	122	22.207	−90.706	−17.213	1.00	42.07	C
ATOM	870	CE2	PHE	A	122	22.940	−90.129	−16.091	1.00	40.14	C
ATOM	871	CD2	PHE	A	122	23.111	−88.193	−15.782	1.00	36.98	C
ATOM	872	C	PHE	A	122	23.237	−85.499	−18.478	1.00	34.50	C
ATOM	873	O	PHE	A	122	22.445	−84.179	−18.595	1.00	32.90	O
ATOM	874	N	LEU	A	123	23.699	−86.192	−19.522	1.00	35.02	N
ATOM	875	CA	LEU	A	123	23.379	−85.840	−20.909	1.00	32.83	C
ATOM	876	CB	LEU	A	123	24.617	−85.598	−21.783	1.00	33.61	C
ATOM	877	CG	LEU	A	123	25.698	−84.893	−21.868	1.00	36.64	C
ATOM	878	CD1	LEU	A	123	27.108	−85.438	−22.093	1.00	35.98	C
ATOM	879	CD2	LEU	A	123	25.412	−83.510	−22.978	1.00	31.11	C
ATOM	880	C	LEU	A	123	22.244	−86.205	−21.453	1.00	32.50	C
ATOM	881	O	LEU	A	123	22.153	−87.897	−21.157	1.00	33.57	O
ATOM	882	N	LEU	A	124	21.369	−86.101	−22.245	1.00	31.29	N
ATOM	883	CA	LEU	A	124	20.314	−86.851	−22.913	1.00	29.75	C
ATOM	884	CB	LEU	A	124	18.987	−86.291	−22.140	1.00	28.35	C
ATOM	885	CG	LEU	A	124	18.906	−87.273	−20.676	1.00	31.38	C
ATOM	886	CD1	LEU	A	124	19.026	−86.126	−19.685	1.00	29.83	C
ATOM	887	CD2	LEU	A	124	17.655	−88.061	−20.358	1.00	33.30	C
ATOM	888	C	LEU	A	124	20.155	−86.222	−24.294	1.00	29.96	C
ATOM	889	O	LEU	A	124	20.109	−85.017	−24.410	1.00	28.89	O
ATOM	890	N	PRO	A	125	20.080	−87.047	−25.354	1.00	29.16	N
ATOM	891	CA	PRO	A	125	19.907	−86.509	−26.706	1.00	28.40	C
ATOM	892	CB	PRO	A	125	20.169	−87.744	−27.579	1.00	26.84	C
ATOM	893	CG	PRO	A	125	19.652	−88.878	−26.749	1.00	27.84	C
ATOM	894	CD	PRO	A	125	19.987	−88.521	−25.322	1.00	26.34	C
ATOM	895	C	PRO	A	125	18.477	−86.029	−27.022	1.00	30.19	C
ATOM	896	O	PRO	A	125	17.519	−86.647	−26.570	1.00	30.76	O
ATOM	897	N	LEU	A	126	18.354	−84.655	−27.803	1.00	31.23	N
ATOM	898	CA	LEU	A	126	17.171	−84.765	−28.645	1.00	32.32	C
ATOM	899	CB	LEU	A	126	16.521	−83.376	−28.481	1.00	29.72	C
ATOM	900	CG	LEU	A	126	16.205	−82.988	−27.035	1.00	28.85	C
ATOM	901	CD1	LEU	A	126	15.994	−81.486	−26.946	1.00	26.19	C
ATOM	902	CD2	LEU	A	126	15.024	−83.765	−26.461	1.00	27.95	C
ATOM	903	C	LEU	A	126	17.627	−84.956	−30.067	1.00	30.78	C
ATOM	904	O	LEU	A	126	18.241	−84.087	−30.643	1.00	30.08	O
ATOM	905	N	ASN	A	127	17.335	−86.122	−30.617	1.00	32.97	N
ATOM	906	CA	ASN	A	127	17.872	−86.509	−31.909	1.00	35.77	C
ATOM	907	CB	ASN	A	127	18.851	−87.697	−31.749	1.00	33.52	C
ATOM	908	CG	ASN	A	127	18.160	−88.947	−31.242	1.00	16.85	C
ATOM	909	CD1	ASN	A	127	16.949	−89.071	−31.364	1.00	42.69	O
ATOM	910	ND2	ASN	A	127	18.915	−89.881	−30.683	1.00	40.00	N
ATOM	911	C	ASN	A	127	16.727	−86.844	−32.845	1.00	35.92	C
ATOM	912	O	ASN	A	127	16.946	−87.363	−33.929	1.00	40.32	O
ATOM	913	N	GLN	A	128	15.501	−86.565	−32.402	1.00	16.76	N
ATOM	914	CA	GLN	A	128	14.334	−36.622	−33.261	1.00	16.24	C
ATOM	915	CB	GLN	A	128	13.730	−88.034	−33.267	1.00	16.87	C
ATOM	916	CG	GLN	A	128	13.245	−88.521	−31.913	1.00	40.55	C
ATOM	917	CD	GLN	A	128	12.756	−89.956	−31.948	1.00	47.09	C
ATOM	918	CE1	GLN	A	128	13.455	−90.838	−32.454	1.00	48.46	O
ATOM	919	NE2	GLN	A	128	11.550	−90.206	−31.398	1.00	43.24	N
ATOM	920	C	GLN	A	128	13.304	−85.566	−32.840	1.00	38.33	C
ATOM	921	O	GLN	A	128	13.511	−84.844	−31.862	1.00	39.56	O
ATOM	922	N	GLU	A	129	12.202	−85.487	−33.590	1.00	38.72	N
ATOM	923	CA	GLU	A	129	11.124	−84.513	−33.356	1.00	41.08	C
ATOM	924	CB	GLU	A	129	10.210	−84.371	−34.586	1.00	43.26	C
ATOM	925	CG	GLU	A	129	9.498	−83.022	−34.650	1.00	46.90	C
ATOM	926	CD	GLU	A	129	8.126	−83.072	−35.303	1.00	48.80	C
ATOM	927	CE1	GLU	A	129	7.961	−83.637	−36.409	1.00	49.26	O
ATOM	928	CE2	GLU	A	129	7.192	−82.511	−34.696	1.00	54.15	O
ATOM	929	C	GLU	A	129	10.269	−84.840	−32.133	1.00	35.82	C
ATOM	930	O	GLU	A	129	10.032	−83.994	−31.300	1.00	37.74	O
ATOM	931	N	ASP	A	130	9.816	−86.071	−32.027	1.00	23.92	N
ATOM	932	CA	ASP	A	130	8.926	−86.431	−30.945	1.00	25.08	C
ATOM	933	CB	ASP	A	130	7.836	−87.406	−31.431	1.00	31.41	C
ATOM	934	CG	ASP	A	130	6.904	−87.815	−30.329	1.00	32.59	C
ATOM	935	OD1	ASP	A	130	6.974	−87.219	−29.224	1.00	31.18	O
ATOM	936	OD2	ASP	A	130	6.077	−88.729	−30.564	1.00	37.35	O
ATOM	937	C	ASP	A	130	9.637	−86.991	−29.711	1.00	33.10	C
ATOM	938	O	ASP	A	130	9.985	−88.138	−29.675	1.00	35.49	O
ATOM	939	N	ASN	A	131	9.765	−86.183	−28.672	1.00	34.41	N
ATOM	940	CA	ASN	A	131	10.343	−86.637	−27.417	1.00	31.97	C
ATOM	941	CB	ASN	A	131	11.647	−85.891	−27.184	1.00	33.06	C
ATOM	942	CG	ASN	A	131	12.628	−86.195	−28.272	1.00	32.62	C
ATOM	943	OD1	ASN	A	131	12.907	−87.359	−28.521	1.00	33.30	O
ATOM	944	ND2	ASN	A	131	13.079	−85.177	−28.986	1.00	33.18	N
ATOM	945	C	ASN	A	131	9.404	−86.482	−26.259	1.00	32.61	C
ATOM	946	O	ASN	A	131	9.815	−86.300	−25.118	1.00	33.22	O
ATOM	947	N	THR	A	132	8.119	−86.603	−26.562	1.00	36.47	N
ATOM	948	CA	THR	A	132	7.107	−86.378	−25.578	1.00	34.63	C
ATOM	949	CB	THR	A	132	5.703	−86.537	−26.381	1.00	32.60	C
ATOM	950	OG1	THR	A	132	5.590	−85.661	−27.308	1.00	33.17	O
ATOM	951	CG2	THR	A	132	4.671	−86.133	−25.191	1.00	32.72	C
ATOM	952	C	THR	A	132	7.381	−87.276	−24.379	1.00	35.27	C
ATOM	953	O	THR	A	132	7.471	−86.793	−23.251	1.00	41.46	O
ATOM	954	N	ASN	A	133	7.574	−88.561	−24.616	1.00	33.91	N
ATOM	955	CA	ASN	A	133	7.653	−89.498	−23.501	1.00	34.90	C
ATOM	956	CB	ASN	A	133	7.421	−90.932	−23.964	1.00	35.59	C
ATOM	957	CG	ASN	A	133	6.981	−91.837	−22.836	1.00	37.71	C
ATOM	958	OD1	ASN	A	133	6.203	−91.438	−21.969	1.00	35.86	O
ATOM	959	ND2	ASN	A	133	7.483	−93.071	−22.836	1.00	36.93	N
ATOM	960	C	ASN	A	133	8.950	−89.382	−22.713	1.00	34.80	C
ATOM	961	O	ASN	A	133	3.951	−89.550	−21.495	1.00	34.13	O
ATOM	962	N	LEU	A	134	10.043	−89.070	−23.413	1.00	36.26	N
ATOM	963	CA	LEU	A	134	11.333	−88.777	−22.769	1.00	34.56	C
ATOM	964	CB	LEU	A	134	12.402	−88.402	−23.814	1.00	34.33	C
ATOM	965	CG	LEU	A	134	13.815	−88.077	−23.319	1.00	35.03	C
ATOM	966	CD1	LEU	A	134	14.673	−89.315	−23.354	1.00	38.14	C
ATOM	967	CD2	LEU	A	134	14.484	−87.033	−24.202	1.00	40.29	C
ATOM	968	C	LEU	A	134	11.129	−87.646	−21.778	1.00	34.38	C
ATOM	969	O	LEU	A	134	11.523	−87.750	−20.619	1.00	32.84	O
ATOM	970	N	ALA	A	135	10.482	−86.570	−22.248	1.00	36.19	N
ATOM	971	CA	ALA	A	135	10.109	−85.423	−21.415	1.00	33.14	C
ATOM	972	CB	ALA	A	135	9.330	−84.408	−22.250	1.00	33.61	C
ATOM	673	C	ALA	A	135	9.295	−85.834	−20.200	1.00	32.42	C
ATOM	974	O	ALA	A	135	9.499	−85.335	−19.096	1.00	32.65	O
ATOM	975	N	ARG	A	136	8.371	−86.762	−20.397	1.00	31.37	N
ATOM	976	CA	ARG	A	136	7.461	−87.105	−19.337	1.00	32.12	C
ATOM	977	CB	ARG	A	136	6.321	−87.973	−19.891	1.00	35.17	C
ATOM	978	CG	ARG	A	136	5.238	−88.298	−18.894	1.00	39.35	C
ATOM	979	CD	ARG	A	136	5.282	−89.741	−18.477	1.00	47.91	C
ATOM	980	NE	ARG	A	136	5.053	−89.837	−17.039	1.00	54.51	N
ATOM	981	CZ	ARG	A	136	5.094	−90.965	−16.339	1.00	58.03	C
ATOM	982	NH1	ARG	A	136	4.870	−90.940	−15.021	1.00	53.04	N
ATOM	983	NH2	ARG	A	136	5.357	−92.115	−16.958	1.00	57.15	N
ATOM	984	C	ARG	A	136	8.255	−87.817	−18.281	1.00	31.06	C
ATOM	985	O	ARG	A	136	8.125	−87.541	−17.092	1.00	30.27	O
ATOM	986	N	VAL	A	137	9.103	−88.738	−18.723	1.00	32.57	N
ATOM	987	CA	VAL	A	137	9.937	−89.491	−17.793	1.00	31.22	C
ATOM	988	CB	VAL	A	137	10.650	−90.570	−18.491	1.00	31.94	C
ATOM	989	CG1	VAL	A	137	11.596	−91.396	−17.535	1.00	33.62	C
ATOM	990	CG2	VAL	A	137	9.610	−91.567	−18.998	1.00	28.88	C
ATOM	991	C	VAL	A	137	10.881	−88.557	−17.036	1.00	29.94	C
ATOM	992	O	VAL	A	137	10.998	−88.554	−15.826	1.00	30.96	O
ATOM	993	N	LEU	A	138	11.487	−87.502	−17.722	1.00	31.14	N
ATOM	994	CA	LEU	A	138	12.464	−86.734	−17.059	1.00	34.45	C
ATOM	995	CB	LEU	A	138	13.264	−85.313	−18.079	1.00	30.40	C
ATOM	996	CG	LEU	A	138	14.264	−84.346	−17.576	1.00	31.89	C
ATOM	997	CD1	LEU	A	138	15.410	−85.413	−16.750	1.00	32.07	C
ATOM	998	CD2	LEU	A	138	14.859	−84.454	−18.728	1.00	27.74	C
ATOM	999	C	LEU	A	138	11.716	−85.538	−16.052	1.00	39.04	C
ATOM	1000	O	LEU	A	138	12.099	−85.751	−14.867	1.00	41.43	O
ATOM	1001	N	THR	A	139	10.630	−85.211	−16.514	1.00	35.31	N
ATOM	1002	CA	THR	A	139	9.809	−84.392	−15.630	1.00	35.02	C
ATOM	1003	CB	THR	A	139	8.531	−83.316	−16.317	1.00	36.66	C
ATOM	1004	OG1	THR	A	139	8.893	−83.085	−17.492	1.00	36.44	O
ATOM	1005	CG2	THR	A	139	7.789	−82.555	−15.402	1.00	34.17	C
ATOM	1006	C	THR	A	139	9.456	−85.210	−14.398	1.00	33.05	C
ATOM	1007	O	THR	A	139	9.588	−84.733	−13.271	1.00	32.26	O
ATOM	1008	N	ASN	A	140	9.056	−86.461	−14.585	1.00	35.53	N
ATOM	1009	CA	ASN	A	140	8.786	−87.269	−13.406	1.00	35.44	C
ATOM	1010	CB	ASN	A	140	8.204	−88.617	−13.750	1.00	38.75	C
ATOM	1011	CG	ASN	A	140	6.684	−88.576	−13.796	1.00	48.19	C
ATOM	1012	OD1	ASN	A	140	6.079	−87.864	−14.622	1.00	44.09	O
ATOM	1013	ND2	ASN	A	140	6.052	−89.313	−12.881	1.00	53.51	N
ATOM	1014	C	ASN	A	140	9.966	−87.179	−12.487	1.00	36.31	C
ATOM	1015	O	ASN	A	140	9.800	−87.159	−11.289	1.00	35.85	O
ATOM	1016	N	HIS	A	141	11.160	−87.662	−13.044	1.00	35.48	N
ATOM	1017	CA	HIS	A	141	12.364	−87.832	−12.243	1.00	33.15	C
ATOM	1018	CB	HIS	A	141	13.568	−88.199	−13.127	1.00	34.49	C
ATOM	1019	CG	HIS	A	141	14.896	−88.155	−12.418	1.00	30.28	C
ATOM	1020	ND1	HIS	A	141	15.279	−89.099	−11.486	1.00	28.92	N
ATOM	1021	CE1	HIS	A	141	16.485	−88.103	−11.029	1.00	29.08	C
ATOM	1022	NE2	HIS	A	141	16.909	−87.115	−11.645	1.00	29.85	N
ATOM	1023	CD2	HIS	A	141	15.936	−87.295	−12.527	1.00	29.68	C
ATOM	1024	C	HIS	A	141	12.633	−86.342	−11.506	1.00	36.12	C
ATOM	1025	O	HIS	A	141	12.988	−86.351	−10.324	1.00	37.23	O
ATOM	1026	N	ILE	A	142	12.446	−85.424	−12.202	1.00	38.27	N
ATOM	1027	CA	ILE	A	142	12.703	−84.125	−11.609	1.00	38.51	C
ATOM	1028	CB	ILE	A	142	12.533	−82.990	−12.631	1.00	38.01	C
ATOM	1029	CG1	ILE	A	142	13.750	−82.965	−13.581	1.00	36.45	C
ATOM	1030	CD1	ILE	A	142	13.630	−82.019	−14.760	1.00	32.51	C
ATOM	1031	CG2	ILE	A	142	12.374	−81.637	−11.926	1.00	34.48	C
ATOM	1032	C	ILE	A	142	11.861	−83.887	−10.359	1.00	43.42	C
ATOM	1033	O	ILE	A	142	12.368	−83.345	−9.380	1.00	42.39	O
ATOM	1034	N	HIS	A	143	10.596	−84.328	−10.385	1.00	47.75	N
ATOM	1035	CA	HIS	A	143	9.679	−84.134	−9.265	1.00	46.81	C
ATOM	1036	CB	HIS	A	143	8.282	−83.827	−9.782	1.00	49.13	C
ATOM	1037	CG	HIS	A	143	8.185	−82.500	−10.458	1.00	53.22	C
ATOM	1038	ND1	HIS	A	143	8.245	−82.357	−11.827	1.00	54.18	N
ATOM	1039	CE1	HIS	A	143	8.148	−81.077	−12.138	1.00	53.73	C
ATOM	1040	NE2	HIS	A	143	8.047	−80.384	−11.019	1.00	53.45	N
ATOM	1041	CD2	HIS	A	143	8.066	−81.249	−9.952	1.00	53.65	C
ATOM	1042	C	HIS	A	143	9.643	−85.306	−3.288	1.00	50.12	C
ATOM	1043	O	HIS	A	143	8.616	−85.562	−7.646	1.00	45.98	O
ATOM	1044	N	THR	A	144	10.766	−86.009	−8.166	1.00	29.73	N
ATOM	1045	CA	THR	A	144	10.864	−87.128	−7.253	1.00	53.11	C
ATOM	1046	CB	THR	A	144	10.937	−88.492	−7.996	1.00	52.87	C
ATOM	1047	OG1	THR	A	144	9.943	−88.552	−9.035	1.00	49.54	O
ATOM	1048	CG2	THR	A	144	10.700	−89.664	−7.078	1.00	50.95	C
ATOM	1049	C	THR	A	144	12.082	−86.858	−6.380	1.00	63.08	C
ATOM	1050	O	THR	A	144	13.167	−87.398	−6.617	1.00	64.74	O
ATOM	1051	N	GLY	A	145	11.882	−85.996	−5.379	1.00	72.97	N
ATOM	1052	CA	GLY	A	145	12.966	−85.433	−4.566	1.00	84.14	C
ATOM	1053	C	GLY	A	145	13.407	−84.112	−5.178	1.00	96.89	C
ATOM	1054	O	GLY	A	145	13.275	−83.918	−6.391	1.00	100.53	O
ATOM	1055	N	HIS	A	146	13.917	−83.195	−4.358	1.00	104.46	N
ATOM	1056	CA	HIS	A	146	14.493	−81.942	−4.879	1.00	109.05	C
ATOM	1057	CB	HIS	A	146	14.007	−80.718	−4.082	1.00	108.83	C
ATOM	1058	CG	HIS	A	146	12.800	−80.048	−4.673	1.00	128.53	C
ATOM	1059	ND1	HIS	A	146	12.892	−79.057	−5.632	1.00	132.36	N
ATOM	1060	CE1	HIS	A	146	11.677	−78.660	−5.969	1.00	130.89	C
ATOM	1061	NE2	HIS	A	146	10.800	−79.354	−5.261	1.00	131.49	N
ATOM	1062	CD2	HIS	A	146	11.476	−60.225	−4.443	1.00	126.49	C
ATOM	1063	C	HIS	A	146	16.024	−82.001	−4.921	1.00	100.91	C
ATOM	1064	O	HIS	A	146	16.669	−82.082	−3.873	1.00	53.78	O
ATOM	1065	N	HIS	A	147	16.586	−81.985	−6.136	1.00	94.42	N
ATOM	1066	CA	HIS	A	147	18.049	−82.034	−6.350	1.00	87.06	C
ATOM	1067	CB	HIS	A	147	18.490	−83.379	−6.937	1.00	81.09	C
ATOM	1068	CG	HIS	A	147	17.940	−84.553	−6.194	1.00	94.04	C
ATOM	1069	ND1	HIS	A	147	17.286	−85.593	−6.820	1.00	97.66	N
ATOM	1070	CE1	HIS	A	147	16.888	−86.468	−5.914	1.00	59.03	C
ATOM	1071	NE2	HIS	A	147	17.245	−86.024	−4.721	1.00	101.81	N
ATOM	1072	CD2	HIS	A	147	17.902	−84.827	−4.868	1.00	93.88	C
ATOM	1073	C	HIS	A	147	18.548	−80.883	−7.212	1.00	81.98	C
ATOM	1074	O	HIS	A	147	17.766	−80.251	−7.928	1.00	74.40	O
ATOM	1075	N	SER	A	148	19.851	−80.618	−7.129	1.00	76.57	N
ATOM	1076	CA	SER	A	148	20.466	−79.480	−7.815	1.00	68.07	C
ATOM	1077	CB	SER	A	148	21.664	−78.963	−7.010	1.00	74.67	C
ATOM	1078	OG	SER	A	148	21.254	−78.173	−5.908	1.00	81.12	O
ATOM	1079	C	SER	A	148	20.923	−79.796	−9.243	1.00	59.76	C
ATOM	1080	O	SER	A	148	20.978	−78.892	−10.089	1.00	56.45	O
ATOM	1081	N	SER	A	149	21.235	−81.071	−9.494	1.00	48.97	N
ATOM	1082	CA	SER	A	149	21.967	−81.488	−10.698	1.00	44.37	C
ATOM	1083	CB	SER	A	149	22.325	−82.957	−10.602	1.00	39.20	C
ATOM	1084	OG	SER	A	149	21.213	−83.739	−10.907	1.00	34.92	O
ATOM	1085	C	SER	A	149	21.286	−81.203	−12.052	1.00	42.40	C
ATOM	1086	O	SER	A	149	20.047	−81.255	−12.170	1.00	40.71	O
ATOM	1087	N	MET	A	150	22.111	−80.934	−13.061	1.00	36.49	N
ATOM	1088	CA	MET	A	150	21.633	−80.491	−14.360	1.00	38.72	C
ATOM	1089	CB	MET	A	150	22.585	−79.471	−14.969	1.00	40.47	C
ATOM	1090	CG	MET	A	150	22.826	−78.236	−14.126	1.00	42.93	C
ATOM	1091	SD	MET	A	150	21.369	−77.215	−13.932	1.00	47.53	S
ATOM	1092	CE	MET	A	150	20.913	−76.862	−15.618	1.00	43.98	C
ATOM	1093	C	MET	A	150	21.440	−81.598	−15.374	1.00	39.06	C
ATOM	1094	O	MET	A	150	22.200	−82.577	−15.423	1.00	37.85	O
ATOM	1095	N	PHE	A	151	20.433	−81.400	−16.214	1.00	36.04	N
ATOM	1096	CA	PHE	A	151	20.241	−82.229	−17.373	1.00	34.87	C
ATOM	1097	CB	PHE	A	151	18.834	−82.798	−17.360	1.00	36.05	C
ATOM	1098	CG	PHE	A	151	18.529	−83.495	−16.090	1.00	34.58	C
ATOM	1099	CD1	PHE	A	151	19.099	−84.738	−15.828	1.00	32.72	C
ATOM	1100	CE1	PHE	A	151	18.860	−85.372	−14.620	1.00	35.71	C
ATOM	1101	CZ	PHE	A	151	18.043	−84.755	−13.654	1.00	36.52	C
ATOM	1102	CE2	PHE	A	151	17.498	−83.500	−13.894	1.00	33.64	C
ATOM	1103	CD2	PHE	A	151	17.757	−82.870	−15.109	1.00	34.38	C
ATOM	1104	C	PHE	A	151	20.554	−81.456	−18.626	1.00	35.92	C
ATOM	1105	O	PHE	A	151	19.864	−80.500	−18.954	1.00	37.71	O
ATOM	1106	N	TRP	A	152	21.633	−81.867	−19.296	1.00	35.79	N
ATOM	1107	CA	TRP	A	152	22.049	−81.296	−20.562	1.00	36.32	C
ATOM	1108	CB	TRP	A	152	23.578	−81.331	−20.691	1.00	37.11	C
ATOM	1109	CG	TRP	A	152	24.314	−80.461	−19.682	1.00	38.50	C
ATOM	1110	CD1	TRP	A	152	23.764	−79.535	−18.824	1.00	41.00	C
ATOM	1111	NE1	TRP	A	152	24.734	−78.963	−18.045	1.00	41.59	N
ATOM	1112	CE2	TRP	A	152	25.946	−79.484	−18.403	1.00	40.77	C
ATOM	1113	CD2	TRP	A	152	25.718	−80.436	−19.432	1.00	41.44	C
ATOM	1114	CE3	TRP	A	152	26.809	−81.131	−19.964	1.00	41.97	C
ATOM	1115	CZ3	TRP	A	152	28.083	−80.348	−19.465	1.00	43.70	C
ATOM	1116	CH2	TRP	A	152	28.270	−79.385	−18.459	1.00	44.66	C
ATOM	1117	CZ2	TRP	A	152	27.212	−79.193	−17.923	1.00	40.23	C
ATOM	1118	C	TRP	A	152	21.404	−82.382	−21.707	1.00	41.05	C
ATOM	1119	O	TRP	A	152	21.629	−83.303	−21.859	1.00	44.03	O
ATOM	1120	N	MET	A	153	20.581	−81.388	−22.491	1.00	37.18	N
ATOM	1121	CA	MET	A	153	20.023	−81.960	−23.700	1.00	36.25	C
ATOM	1122	CB	MET	A	153	18.638	−81.387	−24.020	1.00	36.44	C
ATOM	1123	CG	MET	A	153	17.721	−81.328	−22.817	1.00	32.67	C
ATOM	1124	SD	MET	A	153	17.508	−82.370	−21.899	1.00	34.26	S
ATOM	1125	CE	MET	A	153	16.956	−83.940	−23.218	1.00	31.18	C
ATOM	1126	C	MET	A	153	20.983	−81.726	−24.840	1.00	37.37	C
ATOM	1127	O	MET	A	153	21.430	−80.504	−25.108	1.00	38.14	O
ATOM	1128	N	ARG	A	154	21.328	−82.311	−25.505	1.00	36.44	N
ATOM	1129	CA	ARG	A	154	22.323	−82.746	−26.522	1.00	34.31	C
ATOM	1130	CB	ARG	A	154	23.166	−84.036	−26.487	1.00	36.42	C
ATOM	1131	CG	ARG	A	154	24.172	−84.200	−27.603	1.00	35.95	C
ATOM	1132	CD	ARG	A	154	25.175	−85.272	−27.190	1.00	45.99	C
ATOM	1133	NE	ARG	A	154	26.354	−85.322	−28.060	1.00	49.89	N
ATOM	1134	CZ	ARG	A	154	27.495	−85.947	−27.765	1.00	51.48	C
ATOM	1135	NH1	ARG	A	154	27.643	−86.592	−26.608	1.00	46.22	N
ATOM	1136	NH2	ARG	A	154	28.496	−85.919	−28.643	1.00	51.38	N
ATOM	1137	C	ARG	A	154	21.575	−82.566	−27.817	1.00	31.08	C
ATOM	1138	O	ARG	A	154	20.994	−83.537	−28.347	1.00	30.49	O
ATOM	1139	N	VAL	A	155	21.576	−81.324	−28.309	1.00	28.50	N
ATOM	1140	CA	VAL	A	155	20.893	−80.996	−29.567	1.00	30.78	C
ATOM	1141	CB	VAL	A	155	19.819	−79.863	−29.453	1.00	30.43	C
ATOM	1142	CG1	VAL	A	155	18.622	−80.203	−30.329	1.00	31.14	C
ATOM	1143	CG2	VAL	A	155	19.414	−79.563	−28.031	1.00	28.82	C
ATOM	1144	C	VAL	A	155	21.837	−80.441	−30.605	1.00	30.80	C
ATOM	1145	O	VAL	A	155	22.620	−79.551	−30.309	1.00	34.53	O
ATOM	1146	N	PRO	A	156	21.710	−80.894	−31.851	1.00	31.63	N
ATOM	1147	CA	PRO	A	156	22.595	−80.319	−32.877	1.00	32.38	C
ATOM	1148	CB	PRO	A	156	22.682	−81.417	−33.928	1.00	30.10	C
ATOM	1149	CG	PRO	A	156	21.489	−82.278	−33.711	1.00	31.72	C
ATOM	1150	CD	PRO	A	156	21.047	−82.335	−32.281	1.00	31.39	C
ATOM	1151	C	PRO	A	156	22.071	−79.054	−33.537	1.00	35.29	C
ATOM	1152	O	PRO	A	156	20.857	−78.903	−33.713	1.00	32.71	O
ATOM	1153	N	LEU	A	157	22.981	−78.176	−33.953	1.00	35.31	N
ATOM	1154	CA	LEU	A	157	22.585	−77.067	−34.807	1.00	39.56	C
ATOM	1155	CB	LEU	A	157	23.789	−76.233	−35.243	1.00	40.16	C
ATOM	1156	CG	LEU	A	157	24.280	−75.244	−34.192	1.00	43.04	C
ATOM	1157	CD1	LEU	A	157	25.666	−74.744	−34.549	1.00	44.12	C
ATOM	1158	CD2	LEU	A	157	23.289	−74.093	−34.024	1.00	43.87	C
ATOM	1159	C	LEU	A	157	21.842	−77.584	−36.024	1.00	40.93	C
ATOM	1160	C	LEU	A	157	20.792	−77.060	−36.377	1.00	50.14	O
ATOM	1161	N	VAL	A	158	22.386	−78.620	−36.656	1.00	42.85	N
ATOM	1162	CA	VAL	A	158	21.780	−79.201	−37.848	1.00	38.92	C
ATOM	1163	CB	VAL	A	158	22.716	−79.134	−39.092	1.00	37.97	C
ATOM	1164	CG1	VAL	A	158	21.978	−79.536	−40.373	1.00	35.96	C
ATOM	1165	CG2	VAL	A	158	23.298	−77.742	−39.263	1.00	35.66	C
ATOM	1166	C	VAL	A	158	21.396	−80.629	−37.545	1.00	38.08	C
ATOM	1167	C	VAL	A	158	22.196	−81.385	−37.023	1.00	45.83	O
ATOM	1168	N	ALA	A	159	20.156	−80.974	−37.864	1.00	38.56	N
ATOM	1169	CA	ALA	A	159	19.609	−82.322	−37.704	1.00	40.17	C
ATOM	1170	CB	ALA	A	159	18.122	−82.333	−38.094	1.00	36.87	C
ATOM	1171	C	ALA	A	159	20.372	−83.303	−38.570	1.00	45.97	C
ATOM	1172	O	ALA	A	159	20.705	−82.985	−39.711	1.00	52.42	O
ATOM	1173	N	PRO	A	160	20.645	−84.507	−33.044	1.00	50.70	N
ATOM	1174	CA	PRO	A	160	21.317	−85.561	−38.811	1.00	50.03	C
ATOM	1175	CB	PRO	A	160	21.085	−86.818	−37.956	1.00	54.44	C
ATOM	1176	CG	PRO	A	160	20.131	−86.416	−36.850	1.00	52.54	C
ATOM	1177	CD	PRO	A	160	20.327	−84.948	−36.675	1.00	51.21	C
ATOM	1178	C	PRO	A	160	20.769	−85.738	−40.247	1.00	51.06	C
ATOM	1179	O	PRO	A	160	21.553	−85.752	−41.197	1.00	53.29	O
ATOM	1180	N	GLU	A	161	19.442	−85.828	−40.388	1.00	49.78	N
ATOM	1181	CA	GLU	A	161	18.750	−85.957	−41.679	1.00	44.90	C
ATOM	1182	CB	GLU	A	161	17.237	−86.021	−41.452	1.00	47.87	C
ATOM	1183	CG	GLU	A	161	16.407	−86.365	−42.685	1.00	51.86	C
ATOM	1184	CD	GLU	A	161	16.845	−87.658	−43.359	1.00	55.37	C
ATOM	1185	OE1	GLU	A	161	16.949	−88.688	−42.650	1.00	57.11	O
ATOM	1186	OE2	GLU	A	161	17.073	−87.643	−44.595	1.00	54.32	O
ATOM	1187	C	GLU	A	161	19.046	−84.862	−42.691	1.00	43.77	C
ATOM	1188	O	GLU	A	161	16.589	−85.075	−43.893	1.00	44.32	O
ATOM	1189	N	ASP	A	162	19.462	−83.693	−42.208	1.00	42.40	N
ATOM	1190	CA	ASP	A	162	19.734	−82.538	−43.061	1.00	40.30	C
ATOM	1191	CB	ASP	A	162	19.077	−81.263	−42.475	1.00	58.33	C
ATOM	1192	CG	ASP	A	162	17.513	−81.357	−47.355	1.00	41.46	C
ATOM	1193	OD1	ASP	A	162	16.816	−82.021	−43.167	1.00	39.09	O
ATOM	1194	OD2	ASP	A	162	16.965	−80.727	−41.434	1.00	43.44	O
ATOM	1195	C	ASP	A	162	21.258	−82.364	−43.203	1.00	44.42	C
ATOM	1196	O	ASP	A	162	21.751	−81.416	−43.828	1.00	44.58	O
ATOM	1197	N	LEU	A	163	22.002	−83.288	−42.614	1.00	46.32	N
ATOM	1198	CA	LEU	A	163	23.467	−83.248	−42.675	1.00	52.90	C
ATOM	1199	CB	LEU	A	163	24.040	−81.349	−41.254	1.00	57.29	C
ATOM	1200	CG	LEU	A	163	25.246	−82.509	−40.838	1.00	59.96	C
ATOM	1201	CD1	LEU	A	163	25.184	−81.069	−41.338	1.00	65.27	C
ATOM	1202	CD2	LEU	A	163	25.339	−82.537	−39.324	1.00	62.99	C
ATOM	1203	C	LEU	A	163	24.020	−84.385	−43.554	1.00	49.20	C
ATOM	1204	O	LEU	A	163	25.182	−84.358	−43.944	1.00	49.60	O
ATOM	1205	N	ARG	A	164	23.177	−85.374	−43.860	1.00	46.43	N
ATOM	1206	CA	ARG	A	164	23.603	−86.555	−44.612	1.00	47.06	C
ATOM	1207	CB	ARG	A	164	22.480	−87.601	−44.670	1.00	44.90	C
ATOM	1208	CG	ARG	A	164	21.270	−87.219	−45.503	1.00	46.65	C
ATOM	1209	CD	ARG	A	164	20.257	−88.357	−45.570	1.00	50.19	C
ATOM	1210	NE	ARG	A	164	19.148	−88.027	−46.472	1.00	56.92	N
ATOM	1211	CZ	ARG	A	164	19.187	−88.174	−47.793	1.00	57.00	C
ATOM	1212	NH1	ARG	A	164	20.274	−88.659	−48.386	1.00	61.67	N
ATOM	1213	NH2	ARG	A	164	18.151	−87.818	−48.529	1.00	55.47	N
ATOM	1214	C	ARG	A	164	24.174	−86.236	−46.012	1.00	49.52	C
ATOM	1215	O	ARG	A	164	23.896	−85.177	−46.587	1.00	49.45	O
ATOM	1216	N	ASP	A	165	24.993	−87.148	−46.535	1.00	51.51	N
ATOM	1217	CA	ASP	A	165	25.573	−87.006	−47.876	1.00	52.52	C
ATOM	1218	CB	ASP	A	165	26.718	−88.015	−48.098	1.00	53.42	C
ATOM	1219	CG	ASP	A	165	27.919	−87.771	−47.184	1.00	56.05	C
ATOM	1220	OD1	ASP	A	165	28.046	−86.660	−46.630	1.00	59.27	O
ATOM	1221	OD2	ASP	A	165	28.745	−88.693	−47.008	1.00	61.29	O
ATOM	1222	C	ASP	A	165	24.487	−87.218	−48.921	1.00	52.66	C
ATOM	1223	O	ASP	A	165	23.546	−88.007	−48.719	1.00	54.79	O
ATOM	1224	N	ASP	A	166	24.611	−86.516	−50.038	1.00	51.34	N
ATOM	1225	CA	ASP	A	166	23.660	−86.679	−51.122	1.00	51.36	C
ATOM	1226	CB	ASP	A	166	23.655	−85.432	−51.988	1.00	52.28	C
ATOM	1227	CG	ASP	A	166	22.519	−85.426	−52.996	1.00	57.14	C
ATOM	1228	OD1	ASP	A	166	21.562	−86.249	−52.885	1.00	52.61	O
ATOM	1229	OD2	ASP	A	166	22.603	−84.574	−53.907	1.00	59.06	O
ATOM	1230	C	ASP	A	166	24.022	−87.910	−51.956	1.00	51.01	C
ATOM	1231	O	ASP	A	166	24.447	−87.798	−53.117	1.00	53.77	O
ATOM	1232	N	ILE	A	167	23.854	−89.288	−51.365	1.00	46.84	N
ATOM	1233	CA	ILE	A	167	24.388	−90.302	−51.971	1.00	43.18	C
ATOM	1234	CB	ILE	A	167	25.716	−90.719	−51.300	1.00	39.08	C
ATOM	1235	CG1	ILE	A	167	25.528	−90.997	−49.802	1.00	39.74	C
ATOM	1236	CD1	ILE	A	167	26.707	−91.710	−49.134	1.00	40.26	C
ATOM	1237	CG2	ILE	A	167	26.736	−89.600	−51.454	1.00	39.31	C
ATOM	1238	C	ILE	A	167	23.345	−91.426	−52.067	1.00	44.32	C
ATOM	1239	O	ILE	A	167	23.680	−92.601	−52.266	1.00	44.50	O
ATOM	1240	N	ILE	A	168	22.074	−91.362	−51.958	1.00	43.76	N
ATOM	1241	CA	ILE	A	168	21.021	−92.333	−52.246	1.00	48.32	C
ATOM	1242	CB	ILE	A	168	19.966	−92.140	−51.110	1.00	44.72	C
ATOM	1243	CG1	ILE	A	168	20.642	−92.168	−49.738	1.00	41.90	C
ATOM	1244	CD1	ILE	A	168	19.735	−92.536	−48.589	1.00	41.83	C
ATOM	1245	CG2	ILE	A	168	19.044	−93.340	−51.328	1.00	45.50	C
ATOM	1246	C	ILE	A	168	20.366	−91.558	−53.570	1.00	53.02	C
ATOM	1247	O	ILE	A	168	19.656	−90.549	−53.654	1.00	57.78	O
ATOM	1248	N	AGLU	A	169	20.635	−92.461	−54.599	0.50	53.43	N
ATOM	1249	N	BGLU	A	169	20.608	−92.468	−54.596	0.50	53.86	N
ATOM	1250	CA	AGLU	A	169	20.022	−92.300	−55.920	0.50	53.26	C
ATOM	1251	CA	BGLU	A	169	20.043	−92.345	−55.928	0.50	53.89	C
ATOM	1252	CB	AGLU	A	169	20.216	−93.581	−56.765	0.50	52.10	C
ATOM	1253	CB	BGLU	A	169	20.426	−93.408	−56.864	0.50	53.34	C
ATOM	1254	CG	AGLU	A	169	19.357	−93.573	−58.029	0.50	52.44	C
ATOM	1255	CG	BGLU	A	169	19.826	−93.345	−58.263	0.50	53.82	C
ATOM	1256	CD	AGLU	A	169	18.068	−94.473	−57.839	0.50	50.09	C
ATOM	1257	CD	BGLU	A	169	20.239	−92.106	−59.032	0.50	54.50	C
ATOM	1258	OE1	AGLU	A	169	17.059	−94.168	−58.514	0.50	51.00	O
ATOM	1259	OE1	BGLU	A	169	21.406	−91.679	−58.882	0.50	52.74	O
ATOM	1260	OE2	AGLU	A	169	18.062	−95.421	−57.028	0.50	47.72	O
ATOM	1261	OE2	BGLU	A	169	19.396	−91.166	−59.789	0.50	52.83	O
ATOM	1262	C	AGLU	A	169	18.534	−91.920	−55.813	0.50	53.83	C
ATOM	1263	C	BGLU	A	169	18.512	−91.978	−55.921	0.50	54.50	C
ATOM	1264	O	AGLU	A	169	18.139	−90.139	−56.245	0.50	55.06	O
ATOM	1265	O	BGLU	A	169	18.057	−91.628	−56.556	0.50	56.31	O
ATOM	1266	N	ASN	A	170	17.735	−92.191	−55.199	1.00	51.81	N
ATOM	1267	CA	ASN	A	170	16.260	−97.615	−55.139	1.00	57.08	C
ATOM	1268	CB	ASN	A	170	15.521	−93.967	−55.293	1.00	56.90	C
ATOM	1269	CG	ASN	A	170	15.864	−94.973	−54.190	1.00	57.51	C
ATOM	1270	OD1	ASN	A	170	16.843	−94.820	−53.449	1.00	61.53	O
ATOM	1271	ND2	ASN	A	170	15.066	−96.030	−54.102	1.00	54.48	N
ATOM	1272	C	ASN	A	170	15.687	−91.849	−53.928	1.00	58.96	C
ATOM	1273	O	ASN	A	170	14.493	−91.943	−53.640	1.00	60.16	O
ATOM	1274	N	ALA	A	171	16.539	−91.110	−53.222	1.00	58.15	N
ATOM	1275	CA	ALA	A	171	16.118	−90.265	−52.107	1.00	53.67	C
ATOM	1276	CB	ALA	A	171	16.149	−91.042	−50.798	1.00	48.28	C
ATOM	1277	C	ALA	A	171	17.068	−89.077	−52.040	1.00	58.40	C
ATOM	1278	O	ALA	A	171	17.899	−88.997	−51.130	1.00	55.58	O
ATOM	1279	N	PRO	A	172	16.975	−88.159	−53.021	1.00	62.35	N
ATOM	1280	CA	PRO	A	172	17.919	−87.033	−53.058	1.00	64.86	C
ATOM	1281	CB	PRO	A	172	17.569	−86.325	−54.374	1.00	66.53	C
ATOM	1282	CG	PRO	A	172	16.166	−88.745	−54.678	1.00	61.95	C
ATOM	1283	CD	PRO	A	172	16.061	−88.154	−54.180	1.00	60.92	C
ATOM	1284	C	PRO	A	172	17.738	−81.071	−51.884	1.00	68.16	C
ATOM	1285	O	PRO	A	172	16.637	−85.964	−51.332	1.00	68.80	O
ATOM	1286	N	THR	A	173	18.815	−83.394	−51500	1.00	54.36	N
ATOM	1287	CA	THR	A	173	18.727	−84.379	−50.471	1.00	69.34	C
ATOM	1288	CB	THR	A	173	20.102	−84.063	−49.831	1.00	65.31	C
ATOM	1289	OG1	THR	A	173	21.031	−85.643	−50.840	1.00	56.92	O
ATOM	1290	OG2	THR	A	173	20.656	−85.269	−49.082	1.00	87.76	C
ATOM	1291	C	THR	A	173	18.155	−83.129	−51.129	1.00	80.07	C
ATOM	1292	O	THR	A	173	18.585	−82.752	−52.225	1.00	86.71	O
ATOM	1293	N	THR	A	174	17.182	−82.500	−50.473	1.00	90.28	N
ATOM	1294	CA	THR	A	174	16.485	−81.340	−51.050	1.00	102.38	C
ATOM	1295	CB	THR	A	174	15.071	−81.145	−50.448	1.00	98.17	C
ATOM	1296	CG1	THR	A	174	15.178	−80.756	−49.075	1.00	90.61	O
ATOM	1297	CG2	THR	A	174	14.237	−82.431	−50.554	1.00	96.86	C
ATOM	1298	C	THR	A	174	17.315	−86.050	−50.925	1.00	111.09	C
ATOM	1299	O	THR	A	174	17.556	−75.559	−49.819	1.00	110.36	C
ATOM	1300	N	HIS	A	175	17.746	−79.516	−52.068	1.00	119.93	N
ATOM	1301	CA	HIS	A	175	18.618	−78.332	−52.113	1.00	129.39	C
ATOM	1302	CB	HIS	A	175	19.608	−78.437	−53.287	1.00	138.13	C
ATOM	1303	CG	HIS	A	175	20.919	−79.075	−52.931	1.00	140.99	C
ATOM	1304	ND1	HIS	A	175	21.977	−78.360	−52.409	1.00	139.28	N
ATOM	1305	CE1	HIS	A	175	22.997	−79.174	−52.203	1.00	137.94	C
ATOM	1306	NE2	HIS	A	175	22.642	−80.391	−52.579	1.00	139.69	N
ATOM	1307	CD2	HIS	A	175	21.348	−80.355	−53.042	1.00	139.66	C
ATOM	1308	C	HIS	A	175	17.856	−76.998	−52.184	1.00	126.54	C
ATOM	1309	C	HIS	A	175	18.468	−75.935	−52.331	1.00	123.54	O
ATOM	1310	N	THR	A	176	16.529	−77.060	−52.076	1.00	127.98	N
ATOM	1311	CA	THR	A	176	15.675	−75.864	−52.141	1.00	126.26	C
ATOM	1312	CB	THR	A	176	14.221	−76.216	−52.559	1.00	128.58	C
ATOM	1313	OG1	THR	A	176	13.750	−77.337	−51.805	1.00	105.04	O
ATOM	1314	OG2	THR	A	176	14.154	−76.504	−54.041	1.00	118.87	C
ATOM	1315	C	THR	A	176	15.701	−75.058	−50.827	1.00	129.29	C
ATOM	1316	O	THR	A	176	16.321	−75.483	−49.846	1.00	124.65	O
ATOM	1317	N	GLU	A	177	15.040	−73.896	−50.823	1.00	133.73	N
ATOM	1318	CA	GLU	A	177	15.007	−72.988	−49.660	1.00	133.42	C
ATOM	1319	CB	GLU	A	177	14.721	−71.541	−50.118	1.00	137.54	C
ATOM	1320	CG	GLU	A	177	14.513	−70.506	−49.008	1.00	136.67	C
ATOM	1321	CD	GLU	A	177	15.798	−70.042	−48.325	1.00	132.62	C
ATOM	1322	OE1	GLU	A	177	16.861	−70.684	−48.492	1.00	124.62	O
ATOM	1323	OE2	GLU	A	177	15.741	−69.022	−47.603	1.00	126.25	O
ATOM	1324	C	GLU	A	177	14.021	−73.433	−48.564	1.00	127.32	C
ATOM	1325	O	GLU	A	177	12.829	−73.627	−48.825	1.00	118.23	O
ATOM	1326	N	GLU	A	178	14.539	−73.582	−47.342	1.00	123.33	N
ATOM	1327	CA	GLU	A	178	13.765	−74.065	−46.191	1.00	121.84	C
ATOM	1328	CB	GLU	A	178	14.125	−75.525	−45.903	1.00	122.30	C
ATOM	1329	CG	GLU	A	178	13.129	−76.564	−46.385	1.00	119.96	C
ATOM	1330	CD	GLU	A	178	13.336	−77.911	−45.706	1.00	121.55	C
ATOM	1331	OE1	GLU	A	178	14.470	−78.210	−45.263	1.00	117.94	O
ATOM	1332	OE2	GLU	A	178	12.358	−78.676	−45.607	1.00	120.33	O
ATOM	1333	C	GLU	A	178	13.998	−73.236	−44.915	1.00	116.26	C
ATOM	1334	O	GLU	A	178	14.613	−73.729	−43.961	1.00	114.21	O
ATOM	1335	N	TYR	A	179	13.501	−71.998	−44.888	1.00	108.06	N
ATOM	1336	CA	TYR	A	179	13.728	−71.108	−43.739	1.00	100.36	C
ATOM	1337	CB	TYR	A	179	13.041	−69.738	−43.920	1.00	99.00	C
ATOM	1338	CG	TYR	A	179	13.634	−68.643	−43.039	1.00	96.77	C
ATOM	1339	CD1	TYR	A	179	14.751	−67.903	−43.459	1.00	54.93	C
ATOM	1340	CE1	TYR	A	179	15.302	−66.911	−47.653	1.00	90.64	C
ATOM	1341	CZ	TYR	A	179	14.736	−66.646	−41.405	1.00	88.11	C
ATOM	1342	CZ	TYR	A	179	15.275	−65.667	−40.602	1.00	86.42	O
ATOM	1343	CE2	TYR	A	179	13.636	−67.366	−40.965	1.00	87.46	C
ATOM	1344	CD2	TYR	A	179	13.091	−68.356	−41.778	1.00	93.02	C
ATOM	1345	C	TYR	A	179	13.313	−71.767	−42.416	1.00	95.17	C
ATOM	1346	O	TYR	A	179	14.135	−71.883	−41.492	1.00	79.83	O
ATOM	1347	N	SER	A	180	12.054	−72.216	−42.356	1.00	93.83	N
ATOM	1348	CA	SER	A	180	11.497	−72.927	−41.189	1.00	87.76	C
ATOM	1349	CB	SER	A	180	9.990	−73.136	−41.343	1.00	84.68	C
ATOM	1350	OG	SFR	A	180	9.296	−72.457	−40.318	1.00	81.89	O
ATOM	1351	C	SER	A	180	12.167	−74.267	−40.869	1.00	83.76	C
ATOM	1352	O	SER	A	180	12.551	−74.508	−39.714	1.00	74.06	O
ATOM	1353	N	GLY	A	181	12.288	−75.125	−41.888	1.00	76.76	N
ATOM	1354	CA	GLY	A	181	12.900	−76.448	−41.760	1.00	71.72	C
ATOM	1355	C	GLY	A	181	14.288	−76.473	−41.139	1.00	73.14	C
ATOM	1356	O	GLY	A	181	14.584	−77.346	−40.322	1.00	77.95	O
ATOM	1357	N	GLU	A	182	15.139	−75.519	−41.517	1.00	69.57	N
ATOM	1358	CA	GLU	A	182	16.498	−75.402	−40.951	1.00	68.05	C
ATOM	1359	CB	GLU	A	182	17.355	−74.469	−41.807	1.00	74.05	C
ATOM	1360	CG	GLU	A	182	17.879	−75.153	−43.071	1.00	85.20	C
ATOM	1361	CD	GLU	A	182	17.861	−74.262	−44.306	1.00	85.66	C
ATOM	1362	OE1	GLU	A	182	17.137	−74.615	−45.268	1.00	88.53	O
ATOM	1363	OE2	GLU	A	182	18.564	−73.222	−44.322	1.00	80.17	O
ATOM	1364	C	GLU	A	182	16.504	−74.957	−39.488	1.00	62.09	C
ATOM	1365	O	GLU	A	182	17.544	−74.972	−38.832	1.00	59.86	O
ATOM	1366	N	GLU	A	183	15.332	−74.574	−38.984	1.00	52.21	N
ATOM	1367	CA	GLU	A	183	15.139	−74.342	−37.559	1.00	50.42	C
ATOM	1368	CB	GLU	A	183	14.337	−73.073	−37.350	1.00	55.10	C
ATOM	1369	CG	GLU	A	183	15.109	−71.791	−37.588	1.00	59.16	C
ATOM	1370	CD	GLU	A	183	14.174	−70.632	−37.807	1.00	55.54	C
ATOM	1371	OE1	GLU	A	183	12.962	−70.807	−37.565	1.00	52.47	O
ATOM	1372	OE2	GLU	A	183	14.654	−69.561	−38.213	1.00	61.07	O
ATOM	1373	C	GLU	A	183	14.420	−75.498	−36.835	1.00	44.62	C
ATOM	1374	O	GLU	A	183	13.977	−79.337	−35.693	1.00	42.86	O
ATOM	1375	N	LYS	A	184	14.310	−76.657	−37.478	1.00	38.64	N
ATOM	1376	CA	LYS	A	184	13.520	−77.739	−36.895	1.00	43.93	O
ATOM	1377	CB	LYS	A	184	13.478	−78.969	−37.813	1.00	43.61	C
ATOM	1378	CG	LYS	A	184	14.820	−79.552	−38.063	1.00	43.95	C
ATOM	1379	CD	LYS	A	184	14.623	−81.033	−38.698	1.00	46.05	C
ATOM	1380	CE	LYS	A	184	13.694	−80.014	−39.918	1.00	46.44	C
ATOM	1381	NZ	LYS	A	184	14.249	−80.189	−41.042	1.00	47.35	N
ATOM	1382	C	LYS	A	184	14.028	−78.096	−35.497	1.00	42.94	C
ATOM	1383	O	LYS	A	184	13.255	−78.506	−34.582	1.00	42.94	O
ATOM	1384	N	THR	A	185	15.340	−77.986	−38.363	1.00	38.28	N
ATOM	1385	CA	THR	A	185	16.082	−78.421	−34.218	1.00	37.56	C
ATOM	1386	CB	THR	A	185	17.579	−78.471	−34.615	1.00	37.72	C
ATOM	1387	OG1	THR	A	185	17.959	−79.344	−34.778	1.00	45.90	O
ATOM	1388	CG2	THR	A	185	18.449	−77.340	−33.634	1.00	32.21	C
ATOM	1389	C	THR	A	185	15.802	−77.566	−32.991	1.00	36.52	C
ATOM	1390	O	THR	A	185	15.644	−78.084	−31.868	1.00	36.07	O
ATOM	1391	N	TRP	A	186	15.745	−76.259	−33.194	1.00	34.91	N
ATOM	1392	CA	TRP	A	186	15.294	−75.383	−32.126	1.00	35.33	C
ATOM	1393	CB	TRP	A	186	15.352	−73.907	−32.544	1.00	34.80	C
ATOM	1394	CG	TRP	A	186	14.945	−73.018	−31.438	1.00	35.52	C
ATOM	1395	CD1	TRP	A	186	15.738	−72.506	−30.462	1.00	38.07	C
ATOM	1396	NE1	TRP	A	186	14.996	−71.750	−29.593	1.00	37.48	N
ATOM	1397	CE2	TRP	A	186	13.689	−71.777	−29.995	1.00	38.70	C
ATOM	1398	CD2	TRP	A	186	13.621	−72.572	−31.157	1.00	40.87	C
ATOM	1399	CE3	TRP	A	186	12.368	−72.781	−31.774	1.00	38.85	C
ATOM	1400	CZ3	TRP	A	186	11.267	−72.198	−31.224	1.00	41.00	C
ATOM	1401	CH2	TRP	A	186	11.365	−71.396	−30.068	1.00	43.41	C
ATOM	1402	CZ2	TRP	A	186	12.568	−71.178	−29.438	1.00	41.72	C
ATOM	1403	C	TRP	A	186	13.878	−75.791	−31.650	1.00	32.76	C
ATOM	1404	O	TRP	A	186	13.626	−75.826	−30.448	1.00	35.34	O
ATOM	1405	N	AMET	A	187	12.987	−76.131	−32.577	0.50	31.43	N
ATOM	1406	N	BMET	A	187	12.986	−76.122	−32.586	0.50	31.08	N
ATOM	1407	CA	AMET	A	187	11.635	−76.802	−32.178	0.50	32.20	C
ATOM	1408	CA	BMET	A	187	11.624	−76.533	−32.227	0.50	31.43	C
ATOM	1409	CB	AMET	A	187	10.686	−76.583	−33.371	0.50	31.98	C
ATOM	1410	CB	BMET	A	187	10.734	−76.713	−33.463	0.50	30.90	C
ATOM	1411	CG	AMET	A	187	9.225	−76.645	−32.962	0.50	34.13	C
ATOM	1412	CG	BMET	A	187	9.543	−77.646	−33.260	0.50	31.57	C
ATOM	1413	SD	AMET	A	187	8.671	−75.127	−32.152	0.50	35.19	S
ATOM	1414	SD	BMET	A	187	9.689	−79.290	−34.010	0.50	12.70	S
ATOM	1415	CE	AMET	A	187	8.771	−73.964	−33.515	0.50	29.86	C
ATOM	1416	CE	BMET	A	187	10.066	−78.829	−35.706	0.50	29.35	C
ATOM	1417	C	AMET	A	187	11.624	−77.787	−31.350	0.50	12.21	C
ATOM	1418	C	BMET	A	187	11.630	−77.782	−31.355	0.50	31.79	C
ATOM	1419	C	AMET	A	187	10.813	−77.928	−30.420	0.50	32.68	O
ATOM	1420	O	BMET	A	187	10.837	−77.894	−30.404	0.50	32.28	O
ATOM	1421	N	TRP	A	188	12.547	−73.700	−31.657	1.00	31.38	N
ATOM	1422	CA	TRP	A	188	12.712	−70.935	−30.870	1.00	30.97	C
ATOM	1423	CB	TRP	A	188	13.897	−86.768	−31.375	1.00	30.32	C
ATOM	1424	CG	TRP	A	188	13.779	−81.367	−32.738	1.00	33.37	C
ATOM	1425	CD1	TRP	A	188	12.709	−81.301	−33.588	1.00	33.06	C
ATOM	1426	NE1	TRP	A	188	12.986	−81.987	−34.749	1.00	35.59	N
ATOM	1427	CE2	TRP	A	188	14.255	−82.513	−34.669	1.00	34.58	C
ATOM	1428	CD2	TRP	A	188	14.786	−82.145	−33.411	1.00	33.60	C
ATOM	1429	CE3	TRP	A	188	16.085	−82.562	−33.070	1.00	32.60	C
ATOM	1430	CZ3	TRP	A	188	16.808	−83.339	−33.984	1.00	34.00	C
ATOM	1431	CH2	TRP	A	188	16.249	−83.700	−35.234	1.00	34.57	C
ATOM	1432	CZ2	TRP	A	188	14.980	−81.299	−15.597	1.00	33.65	C
ATOM	1433	C	TRP	A	188	12.954	−79.612	−29.396	1.00	30.98	C
ATOM	1434	O	TRP	A	188	12.310	−80.176	−28.472	1.00	34.18	O
ATOM	1435	N	TRP	A	189	13.888	−78.690	−29.197	1.00	27.49	N
ATOM	1436	CA	TRP	A	189	14.238	−78.198	−27.885	1.00	25.43	C
ATOM	1437	CB	TRP	A	189	15.509	−77.365	−27.995	1.00	21.27	C
ATOM	1438	CG	TRP	A	189	15.626	−76.358	−26.931	1.00	29.24	C
ATOM	1439	CD1	TRP	A	189	15.546	−74.994	−27.081	1.00	28.17	C
ATOM	1440	NE1	TRP	A	189	15.711	−74.577	−25.855	1.00	27.62	N
ATOM	1441	CE2	TRP	A	189	15.926	−75.336	−24.905	1.00	27.74	C
ATOM	1442	CD2	TRP	A	189	15.875	−76.596	−25.546	1.00	28.09	C
ATOM	1443	CE3	TRP	A	189	16.082	−77.746	−24.790	1.00	20.51	C
ATOM	1444	CZ3	TRP	A	189	16.308	−77.613	−23.416	1.00	21.33	C
ATOM	1445	CH2	TRP	A	189	16.320	−76.340	−22.801	1.00	20.68	C
ATOM	1446	CZ2	TRP	A	189	16.125	−75.197	−23.535	1.00	29.27	C
ATOM	1447	C	TRP	A	189	13.130	−77.316	−27.294	1.00	25.22	C
ATOM	1448	C	TRP	A	189	12.789	−77.444	−26.109	1.00	24.83	O
ATOM	1449	N	HIS	A	190	12.647	−76.359	−28.077	1.00	25.34	N
ATOM	1450	CA	HIS	A	190	11.520	−75.541	−27.588	1.00	29.33	C
ATOM	1451	CB	HIS	A	190	10.944	−74.647	−28.665	1.00	29.69	C
ATOM	1452	CG	HIS	A	190	9.806	−73.799	−28.186	1.00	34.05	C
ATOM	1453	ND1	HIS	A	190	9.934	−72.900	−27.147	1.00	35.81	N
ATOM	1454	CE1	HIS	A	190	8.787	−72.289	−26.946	1.00	30.34	C
ATOM	1455	NE2	HIS	A	190	7.920	−72.749	−27.826	1.00	32.98	N
ATOM	1456	CD2	HIS	A	190	8.525	−73.705	−28.604	1.00	29.25	C
ATOM	1457	C	HIS	A	190	10.438	−76.444	−27.011	1.00	25.83	C
ATOM	1458	O	HIS	A	190	10.120	−76.329	−25.840	1.00	24.66	O
ATOM	1459	N	ASN	A	191	9.959	−77.397	−27.802	1.00	27.12	N
ATOM	1460	CA	ASN	A	191	8.839	−78.254	−27.359	1.00	30.70	C
ATOM	1461	CB	ASN	A	191	8.376	−79.187	−28.468	1.00	29.58	C
ATOM	1462	CG	ASN	A	191	7.711	−78.434	−29.584	1.00	31.40	C
ATOM	1463	OD1	ASN	A	191	7.492	−77.233	−29.478	1.00	34.13	N
ATOM	1464	ND2	ASN	A	191	7.400	−79.113	−30.657	1.00	32.43	N
ATOM	1465	C	ASN	A	191	9.164	−79.050	−26.139	1.00	32.59	C
ATOM	1466	O	ASN	A	191	8.311	−79.185	−25.253	1.00	38.14	O
ATOM	1467	N	PHE	A	192	10.397	−79.564	−26.070	1.00	33.01	N
ATOM	1468	CA	PHE	A	192	10.769	−80.461	−21.976	1.00	31.17	C
ATOM	1469	CB	PHE	A	192	12.174	−83.047	−25.189	1.00	28.17	C
ATOM	1470	CG	PHE	A	192	12.651	−81.922	−24.055	1.00	26.09	C
ATOM	1471	CD1	PHE	A	192	12.253	−83.248	−23.968	1.00	25.91	C
ATOM	1472	CE1	PHE	A	192	12.676	−84.068	−22.926	1.00	24.69	C
ATOM	1473	CZ	PHE	A	192	13.545	−83.557	−21.971	1.00	29.24	C
ATOM	1474	CE2	PHE	A	192	13.977	−82.234	−22.050	1.00	27.98	C
ATOM	1475	CD2	PHE	A	192	13.522	−81.422	−23.087	1.00	27.76	C
ATOM	1476	C	PHE	A	192	10.722	−79.685	−23.683	1.00	32.70	C
ATOM	1477	O	PHE	A	192	10.188	−80.149	−22.657	1.00	36.27	O
ATOM	1478	N	ARG	A	193	11.274	−78.488	−73.756	1.00	30.75	N
ATOM	1479	CA	ARG	A	193	11.442	−77.649	−22.605	1.00	34.11	C
ATOM	1480	CB	ARG	A	193	12.410	−76.526	−22.970	1.00	40.38	C
ATOM	1481	CG	ARG	A	193	12.101	−75.308	−22.151	1.00	52.06	C
ATOM	1482	CD	ARG	A	193	12.595	−74.035	−22.763	1.00	53.51	C
ATOM	1483	NE	ARG	A	193	11.848	−73.552	−23.919	1.00	42.43	N
ATOM	1484	CZ	ARG	A	193	12.394	−72.623	−24.683	1.00	39.66	C
ATOM	1485	NH1	ARG	A	193	13.598	−72.193	−24.362	1.00	40.87	N
ATOM	1486	NH2	ARG	A	193	11.801	−72.141	−25.740	1.00	37.40	N
ATOM	1487	C	ARG	A	193	10.086	−77.060	−22.150	1.00	33.52	C
ATOM	1488	O	ARG	A	193	9.901	−76.711	−20.996	1.00	31.02	O
ATOM	1489	N	THR	A	194	9.146	−76.945	−23.073	1.00	34.53	N
ATOM	1490	CA	THR	A	194	7.814	−76.480	−22.750	1.00	32.01	C
ATOM	1491	CB	THR	A	194	7.076	−76.064	−24.015	1.00	30.50	C
ATOM	1492	OG1	THR	A	194	7.798	−75.009	−24.654	1.00	27.41	O
ATOM	1493	CG2	THR	A	194	5.678	−75.608	−23.687	1.00	28.74	C
ATOM	1494	C	THR	A	194	7.057	−77.580	−22.017	1.00	32.98	C
ATOM	1495	O	THR	A	194	6.419	−77.338	−20.997	1.00	36.47	O
ATOM	1496	N	LEU	A	195	7.162	−78.793	−22.531	1.00	32.61	N
ATOM	1497	CA	LEU	A	195	6.520	−79.934	−21.918	1.00	31.20	C
ATOM	1498	CB	LEU	A	195	6.820	−81.205	−22.719	1.00	28.87	C
ATOM	1499	CG	LEU	A	195	6.080	−81.448	−24.049	1.00	29.37	C
ATOM	1500	CD1	LEU	A	195	6.746	−82.524	−24.885	1.00	24.51	C
ATOM	1501	CD2	LEU	A	195	4.626	−81.837	−23.823	1.00	25.05	C
ATOM	1502	C	LEU	A	195	7.004	−80.102	−20.481	1.00	34.23	C
ATOM	1503	O	LEU	A	195	6.219	−80.505	−19.604	1.00	30.54	O
ATOM	1504	N	CYS	A	196	8.300	−79.824	−20.267	1.00	35.78	N
ATOM	1505	CA	CYS	A	196	8.961	−79.986	−18.960	1.00	38.55	C
ATOM	1506	CB	CYS	A	196	10.461	−80.258	−19.134	1.00	38.55	C
ATOM	1507	SG	CYS	A	196	10.959	−81.866	−19.794	1.00	35.83	S
ATOM	1508	C	CYS	A	196	8.807	−78.721	−18.102	1.00	42.41	C
ATOM	1509	O	CYS	A	196	9.459	−78.577	−17.066	1.00	42.97	O
ATOM	1510	N	ASP	A	197	7.961	−77.804	−18.565	1.00	42.95	N
ATOM	1511	CA	ASP	A	197	7.610	−76.597	−17.841	1.00	39.07	C
ATOM	1512	CB	ASP	A	197	6.753	−76.939	−16.619	1.00	40.51	C
ATOM	1513	CG	ASP	A	197	5.838	−75.796	−16.202	1.00	45.90	C
ATOM	1514	OD1	ASP	A	197	5.836	−74.715	−16.846	1.00	44.05	O
ATOM	1515	OD2	ASP	A	197	5.102	−75.999	−15.216	1.00	51.60	O
ATOM	1516	C	ASP	A	197	8.826	−75.737	−17.462	1.00	35.39	C
ATOM	1517	O	ASP	A	197	8.960	−75.281	−16.325	1.00	30.56	O
ATOM	1518	N	TYR	A	198	9.679	−75.491	−18.444	1.00	34.02	N
ATOM	1519	CA	TYR	A	198	10.859	−74.524	−18.273	1.00	35.09	C
ATOM	1520	CB	TYR	A	198	10.422	−73.153	−18.202	1.00	33.06	C
ATOM	1521	CG	TYR	A	198	10.056	−72.566	−19.524	1.00	33.43	C
ATOM	1522	CD1	TYR	A	198	8.779	−72.751	−20.040	1.00	33.31	C
ATOM	1523	CE1	TYR	A	198	8.423	−72.236	−21.264	1.00	33.44	C
ATOM	1524	CZ	TYR	A	198	9.325	−71.512	−21.991	1.00	33.07	C
ATOM	1525	OH	TYR	A	198	8.902	−71.314	−23.208	1.00	35.42	O
ATOM	1526	CE2	TYR	A	198	10.619	−71.314	−21.516	1.00	33.96	C
ATOM	1527	CD2	TYR	A	198	10.980	−71.337	−20.278	1.00	32.27	C
ATOM	1528	C	TYR	A	198	11.702	−74.915	−17.033	1.00	32.91	C
ATOM	1529	O	TYR	A	198	12.178	−73.983	−16.424	1.00	35.52	O
ATOM	1530	N	SER	A	199	11.840	−76.170	−16.614	1.00	32.75	N
ATOM	1531	CA	SER	A	199	12.571	−76.474	−15.388	1.00	33.42	C
ATOM	1532	CB	SER	A	199	12.671	−77.985	−15.198	1.00	33.62	C
ATOM	1533	OG	SER	A	199	13.722	−78.235	−14.281	1.00	35.25	O
ATOM	1534	C	SER	A	199	13.997	−75.850	−15.438	1.00	35.64	C
ATOM	1535	O	SER	A	199	14.651	−75.877	−16.480	1.00	33.93	O
ATOM	1536	N	LYS	A	200	14.461	−75.270	−14.333	1.00	35.39	N
ATOM	1537	CA	LYS	A	200	15.756	−74.593	−14.336	1.00	36.26	C
ATOM	1538	CB	LYS	A	200	15.923	−73.725	−13.080	1.00	39.09	C
ATOM	1539	CG	LYS	A	200	16.065	−74.529	−11.789	1.00	46.57	C
ATOM	1540	CD	LYS	A	200	16.182	−73.630	−10.565	1.00	54.64	C
ATOM	1541	CE	LYS	A	200	16.483	−74.447	−9.310	1.00	40.60	O
ATOM	1542	NZ	LYS	A	200	16.119	−73.716	−8.055	1.00	39.80	N
ATOM	1543	C	LYS	A	200	16.868	−75.635	−14.447	1.00	34.37	C
ATOM	1544	O	LYS	A	200	18.039	−75.292	−14.625	1.00	37.42	O
ATOM	1545	N	ARG	A	201	16.484	−76.907	−14.360	1.00	30.65	N
ATOM	1546	CA	ARG	A	201	17.440	−78.018	−14.330	1.00	30.00	C
ATOM	1547	CB	ARG	A	201	16.947	−79.129	−13.410	1.00	36.85	C
ATOM	1548	CG	ARG	A	201	17.032	−78.765	−11.950	1.00	30.38	C
ATOM	1549	CD	ARG	A	201	16.538	−79.904	−11.087	1.00	34.56	C
ATOM	1550	NE	ARG	A	201	17.518	−80.988	−10.976	1.00	19.82	N
ATOM	1551	CZ	ARG	A	201	17.238	−82.192	−10.476	1.00	42.57	C
ATOM	1552	NH1	ARG	A	201	16.002	−82.467	−10.050	1.00	40.85	N
ATOM	1553	NH2	ARG	A	201	18.186	−83.125	−10.412	1.00	42.39	N
ATOM	1554	C	ARG	A	201	17.745	−78.595	−15.721	1.00	29.66	C
ATOM	1555	O	ARG	A	201	18.548	−79.509	−15.867	1.00	32.55	O
ATOM	1556	N	ILE	A	202	17.119	−78.043	−16.741	1.00	27.78	N
ATOM	1557	CA	ILE	A	202	17.250	−78.579	−18.067	1.00	26.81	C
ATOM	1558	CB	ILE	A	202	15.884	−79.009	−18.605	1.00	28.34	C
ATOM	1559	CG1	ILE	A	202	15.303	−80.094	−17.676	1.00	26.98	C
ATOM	1560	CD1	ILE	A	202	13.813	−80.400	−17.854	1.00	28.62	C
ATOM	1561	CG2	ILE	A	202	16.017	−79.458	−20.053	1.00	27.83	C
ATOM	1562	C	ILE	A	202	17.862	−77.513	−18.928	1.00	27.66	C
ATOM	1563	O	ILE	A	202	17.326	−76.422	−19.049	1.00	28.92	O
ATOM	1564	N	ALA	A	203	19.034	−77.809	−19.484	1.00	28.89	N
ATOM	1565	CA	ALA	A	203	19.783	−76.820	−20.225	1.00	26.69	C
ATOM	1566	CB	ALA	A	203	20.939	−76.355	−19.393	1.00	26.16	C
ATOM	1567	C	ALA	A	203	20.220	−77.410	−21.564	1.00	27.71	C
ATOM	1568	O	ALA	A	203	19.976	−78.585	−21.812	1.00	27.85	O
ATOM	1569	N	VAL	A	204	20.801	−76.597	−22.449	1.00	30.11	N
ATOM	1570	CA	VAL	A	204	21.213	−77.068	−23.785	1.00	28.43	C
ATOM	1571	CB	VAL	A	204	20.834	−76.053	−24.877	1.00	28.01	C
ATOM	1572	CG1	VAL	A	204	21.169	−76.573	−26.286	1.00	25.08	C
ATOM	1573	CG2	VAL	A	204	19.325	−75.741	−24.773	1.00	32.32	C
ATOM	1574	C	VAL	A	204	22.721	−77.406	−23.835	1.00	33.56	C
ATOM	1575	O	VAL	A	204	23.588	−76.639	−23.359	1.00	30.75	O
ATOM	1576	N	ALA	A	205	23.003	−78.599	−24.357	1.00	35.20	N
ATOM	1577	CA	ALA	A	205	24.348	−78.995	−24.787	1.00	33.84	C
ATOM	1578	CB	ALA	A	205	24.648	−80.414	−24.315	1.00	31.37	C
ATOM	1579	C	ALA	A	205	24.356	−78.906	−26.318	1.00	32.42	C
ATOM	1580	O	ALA	A	205	24.040	−79.862	−27.005	1.00	31.38	O
ATOM	1581	N	LEU	A	206	24.693	−77.744	−26.851	1.00	34.03	N
ATOM	1582	CA	LEU	A	206	24.529	−77.492	−28.274	1.00	36.06	C
ATOM	1583	CB	LEU	A	206	24.491	−75.979	−28.510	1.00	33.53	C
ATOM	1584	CG	LEU	A	206	24.278	−75.390	−29.908	1.00	35.38	C
ATOM	1585	CD1	LEU	A	206	22.862	−75.595	−30.451	1.00	36.00	C
ATOM	1586	CD2	LEU	A	206	24.617	−73.906	−29.878	1.00	33.64	C
ATOM	1587	C	LEU	A	206	25.637	−78.173	−29.089	1.00	39.89	C
ATOM	1588	O	LEU	A	206	26.818	−77.860	−28.908	1.00	43.36	O
ATOM	1589	N	GLU	A	207	25.260	−79.124	−29.951	1.00	42.83	N
ATOM	1590	CA	GLU	A	207	26.210	−79.808	−30.842	1.00	47.01	C
ATOM	1591	CB	GLU	A	207	25.757	−81.228	−31.164	1.00	49.08	C
ATOM	1592	CG	GLU	A	207	26.579	−82.275	−30.433	1.00	50.80	C
ATOM	1593	CD	GLU	A	207	26.464	−83.678	−31.000	1.00	53.64	C
ATOM	1594	OE1	GLU	A	207	25.574	−84.440	−30.567	1.00	59.53	O
ATOM	1595	OE2	GLU	A	207	27.290	−84.042	−31.855	1.00	52.22	O
ATOM	1596	C	GLU	A	207	26.491	−79.050	−32.138	1.00	49.28	C
ATOM	1597	O	GLU	A	207	25.581	−78.812	−37.935	1.00	50.07	O
ATOM	1598	N	ILE	A	208	27.758	−78.685	−32.335	1.00	46.63	N
ATOM	1599	CA	ILE	A	208	28.197	−77.944	−33.525	1.00	50.01	C
ATOM	1600	CB	ILE	A	208	29.200	−76.837	−33.133	1.00	51.62	C
ATOM	1601	CG1	ILE	A	208	28.591	−75.968	−32.034	1.00	50.90	C
ATOM	1602	CD1	ILE	A	208	29.607	−75.096	−31.339	1.00	56.71	C
ATOM	1603	CG2	ILE	A	208	29.585	−75.968	−34.328	1.00	45.22	C
ATOM	1604	C	ILE	A	208	28.769	−78.861	−34.620	1.00	49.82	C
ATOM	1605	O	ILE	A	208	29.522	−79.787	−34.341	1.00	49.77	O
ATOM	1606	N	GLY	A	209	28.380	−78.612	−35.865	1.00	50.94	N
ATOM	1607	CA	GLY	A	209	28.795	−79.452	−36.991	1.00	53.08	C
ATOM	1608	C	GLY	A	209	29.771	−78.796	−37.964	1.00	56.16	C
ATOM	1609	O	GLY	A	209	30.042	−77.584	−37.895	1.00	51.38	O
ATOM	1610	N	ALA	A	210	30.300	−79.618	−38.875	1.00	61.54	N
ATOM	1611	CA	ALA	A	210	31.269	−79.178	−39.879	1.00	60.31	C
ATOM	1612	CB	ALA	A	210	31.625	−80.323	−40.824	1.00	60.56	C
ATOM	1613	C	ALA	A	210	30.702	−77.992	−40.632	1.00	62.80	C
ATOM	1614	O	ALA	A	210	31.355	−76.957	−40.752	1.00	65.39	O
ATOM	1615	N	ASP	A	211	29.458	−78.142	−41.080	1.00	63.65	N
ATOM	1616	CA	ASP	A	211	28.722	−77.100	−41.771	1.00	67.04	C
ATOM	1617	CB	ASP	A	211	27.819	−77.733	−42.835	1.00	74.66	C
ATOM	1618	CG	ASP	A	211	28.507	−77.886	−44.179	1.00	80.02	C
ATOM	1619	OD1	ASP	A	211	29.711	−78.240	−44.232	1.00	84.34	O
ATOM	1620	OD2	ASP	A	211	27.826	−77.652	−45.196	1.00	81.89	O
ATOM	1621	C	ASP	A	211	27.857	−76.330	−40.794	1.00	65.06	C
ATOM	1622	O	ASP	A	211	26.860	−76.358	−40.303	1.00	64.61	O
ATOM	1623	N	LEU	A	212	28.230	−75.390	−40.505	1.00	62.01	N
ATOM	1624	CA	LEU	A	212	27.365	−74.244	−39.708	1.00	65.23	C
ATOM	1625	CB	LEU	A	212	28.000	−72.392	−39.362	1.00	60.58	C
ATOM	1626	CG	LEU	A	212	29.244	−72.312	−38.475	1.00	59.84	C
ATOM	1627	CD1	LEU	A	212	29.402	−71.398	−37.936	1.00	59.85	C
ATOM	1628	CD2	LEU	A	212	29.194	−73.111	−37.330	1.00	59.84	C
ATOM	1629	C	LEU	A	212	26.138	−74.009	−40.543	1.00	75.57	C
ATOM	1630	O	LEU	A	212	26.250	−73.320	−41.758	1.00	83.07	O
ATOM	1631	N	PRO	A	213	24.958	−74.021	−39.906	1.00	81.11	N
ATOM	1632	CA	PRO	A	213	23.761	−73.735	−40.669	1.00	81.74	C
ATOM	1633	CB	PRO	A	213	22.649	−74.965	−39.680	1.00	81.91	C
ATOM	1634	CG	PRO	A	213	23.239	−73.687	−38.361	1.00	82.11	C
ATOM	1635	CD	PRO	A	213	24.687	−74.074	−38.455	1.00	78.56	C
ATOM	1636	C	PRO	A	213	23.774	−72.246	−40.967	1.00	84.53	C
ATOM	1637	O	PRO	A	213	24.734	−71.356	−40.594	1.00	80.25	O
ATOM	1638	N	SER	A	214	22.725	−71.759	−41.626	1.00	84.69	N
ATOM	1639	CA	SER	A	214	22.531	−70.326	−41.810	1.00	82.62	C
ATOM	1640	CB	SER	A	214	21.175	−70.057	−42.457	1.00	87.35	C
ATOM	1641	OG	SER	A	214	21.224	−70.314	−43.849	1.00	88.05	O
ATOM	1642	C	SER	A	214	22.664	−69.572	−40.482	1.00	73.33	C
ATOM	1643	O	SER	A	214	22.487	−70.158	−39.409	1.00	72.81	O
ATOM	1644	N	AASN	A	215	22.991	−63.286	−40.565	0.50	72.89	N
ATOM	1645	N	BASN	A	215	22.987	−68.282	−40.571	0.50	73.84	N
ATOM	1646	CA	AASN	A	215	23.177	−67.458	−39.377	0.50	69.84	C
ATOM	1647	CA	BASN	A	215	23.176	−67.427	−39.397	0.50	70.80	C
ATOM	1648	CB	AASN	A	215	23.741	−66.082	−39.735	0.50	64.47	C
ATOM	1649	CB	BASN	A	215	23.656	−66.026	−39.794	0.50	66.68	C
ATOM	1650	CG	AASN	A	215	25.234	−65.991	−39.493	0.50	62.58	C
ATOM	1651	CG	BASN	A	215	23.653	−65.054	−38.623	0.50	65.99	C
ATOM	1652	OD1	AASN	A	215	25.945	−66.994	−39.561	0.50	59.06	O
ATOM	1653	OD1	BASN	A	215	24.575	−64.255	−38.453	0.50	63.08	O
ATOM	1654	ND2	AASN	A	215	25.716	−64.190	−39.194	0.50	60.09	N
ATOM	1655	ND2	BASN	A	215	22.615	−65.125	−37.806	0.50	64.16	N
ATOM	1656	C	AASN	A	215	21.917	−67.312	−38.550	0.50	70.25	C
ATOM	1657	C	BASN	A	215	21.920	−67.321	−38.555	0.50	70.84	C
ATOM	1658	O	AASN	A	215	21.995	−67.146	−37.336	0.50	70.82	O
ATOM	1659	O	BASN	A	215	22.006	−67.188	−37.337	0.50	71.01	O
ATOM	1660	N	HIS	A	216	20.761	−67.392	−39.210	1.00	72.25	N
ATOM	1661	CA	HIS	A	216	19.472	−67.265	−38.518	1.00	74.24	C
ATOM	1662	CB	HIS	A	216	18.289	−66.996	−39.484	1.00	70.91	C
ATOM	1663	CG	HIS	A	216	17.870	−68.174	−40.318	1.00	79.61	C
ATOM	1664	ND1	HIS	A	216	16.718	−68.896	−40.068	1.00	77.20	N
ATOM	1665	CE1	HIS	A	216	16.590	−69.847	−40.977	1.00	73.60	C
ATOM	1666	NE2	HIS	A	216	17.612	−69.766	−41.812	1.00	74.72	N
ATOM	1667	CD2	HIS	A	216	18.421	−68.723	−41.429	1.00	76.91	C
ATOM	1668	C	HIS	A	216	19.230	−68.416	−37.537	1.00	70.18	C
ATOM	1669	O	HIS	A	216	18.808	−68.203	−36.405	1.00	68.50	O
ATOM	1670	N	VAL	A	217	19.570	−69.623	−37.963	1.00	70.58	N
ATOM	1671	CA	VAL	A	217	19.495	−70.797	−37.111	1.00	72.75	C
ATOM	1672	CB	VAL	A	217	19.873	−72.079	−37.900	1.00	32.25	C
ATOM	1673	CG1	VAL	A	217	19.478	−73.339	−37.130	1.00	85.79	C
ATOM	1674	CG2	VAL	A	217	19.232	−72.077	−39.292	1.00	77.22	C
ATOM	1675	C	VAL	A	217	20.370	−70.620	−35.855	1.00	76.30	C
ATOM	1676	O	VAL	A	217	20.035	−71.146	−34.798	1.00	88.07	O
ATOM	1677	N	ILE	A	218	21.469	−69.865	−35.969	1.00	71.39	N
ATOM	1678	CA	ILE	A	218	22.334	−69.512	−34.829	1.00	63.62	C
ATOM	1679	CB	ILE	A	218	23.802	−69.232	−35.296	1.00	64.81	C
ATOM	1680	CG1	ILE	A	218	24.488	−70.535	−35.722	1.00	66.65	C
ATOM	1681	CD1	ILE	A	218	25.585	−70.375	−36.765	1.00	65.69	C
ATOM	1682	CG2	ILE	A	218	24.642	−68.540	−34.221	1.00	57.45	C
ATOM	1683	C	ILE	A	218	21.753	−69.306	−34.094	1.00	63.80	C
ATOM	1684	O	ILE	A	218	22.251	−67.892	−33.045	1.00	66.39	O
ATOM	1685	N	ASP	A	219	20.711	−67.722	−34.667	1.00	65.81	N
ATOM	1686	CA	ASP	A	219	20.006	−66.637	−34.005	1.00	70.35	C
ATOM	1687	CB	ASP	A	219	19.203	−65.788	−35.010	1.00	68.11	C
ATOM	1688	CG	ASP	A	219	20.090	−64.970	−35.974	1.00	66.72	C
ATOM	1689	OD1	ASP	A	219	21.340	−64.890	−35.776	1.00	56.49	O
ATOM	1690	OD2	ASP	A	219	19.499	−64.397	−36.935	1.00	58.92	O
ATOM	1691	C	ASP	A	219	19.076	−67.250	−32.947	1.00	68.16	C
ATOM	1692	O	ASP	A	219	18.964	−66.749	−31.814	1.00	60.18	O
ATOM	1693	N	ARG	A	220	18.433	−68.356	−33.323	1.00	65.96	N
ATOM	1694	CA	ARG	A	220	17.443	−69.022	−32.474	1.00	64.92	C
ATOM	1695	CB	ARG	A	220	17.120	−70.408	−33.032	1.00	60.94	C
ATOM	1696	CG	ARG	A	220	16.152	−70.424	−34.199	1.00	54.97	C
ATOM	1697	CD	ARG	A	220	15.163	−69.309	−34.047	1.00	57.59	C
ATOM	1698	NE	ARG	A	220	13.806	−69.737	−34.310	1.00	63.59	N
ATOM	1699	CZ	ARG	A	220	12.841	−69.741	−33.393	1.00	75.12	C
ATOM	1700	NH1	ARG	A	220	13.089	−69.331	−32.146	1.00	71.79	N
ATOM	1701	NH2	ARG	A	220	11.619	−70.144	33.730	1.00	81.53	N
ATOM	1702	C	ARG	A	220	17.964	−69.190	−31.062	1.00	67.63	C
ATOM	1703	O	ARG	A	220	17.280	−68.872	−30.093	1.00	74.03	O
ATOM	1704	N	TRP	A	221	19.206	−69.661	−30.977	1.00	56.04	N
ATOM	1705	CA	TRP	A	221	19.794	−70.167	−29.760	1.00	43.04	C
ATOM	1706	CB	TRP	A	221	20.920	−71.106	−30.145	1.00	37.72	C
ATOM	1707	CG	TRP	A	221	20.425	−72.300	−30.859	1.00	31.33	C
ATOM	1708	CD1	TRP	A	221	20.512	−72.572	−32.200	1.00	28.18	C
ATOM	1709	NE1	TRP	A	221	19.927	−73.780	−32.469	1.00	27.07	N
ATOM	1710	CE2	TRP	A	221	19.441	−74.306	−31.298	1.00	28.54	C
ATOM	1711	CD2	TRP	A	221	19.734	−73.395	−30.268	1.00	29.38	C
ATOM	1712	CE3	TRP	A	221	19.325	−73.689	−28.966	1.00	27.88	C
ATOM	1713	CZ3	TRP	A	221	18.650	−74.889	−23.732	1.00	23.60	C
ATOM	1714	CH2	TRP	A	221	18.369	−75.769	−29.773	1.00	23.57	C
ATOM	1715	CZ2	TRP	A	221	18.752	−75.496	−31.062	1.00	31.07	C
ATOM	1716	C	TRP	A	221	20.321	−69.069	−28.881	1.00	44.95	C
ATOM	1717	O	TRP	A	221	20.901	−69.335	−27.809	1.00	43.09	O
ATOM	1718	N	LEU	A	222	20.104	−67.834	−29.323	1.00	47.35	N
ATOM	1719	CA	LEU	A	222	20.752	−66.684	−28.685	1.00	51.38	C
ATOM	1720	CB	LEU	A	222	20.453	−65.354	−29.423	1.00	43.90	C
ATOM	1721	CG	LEU	A	222	20.859	−65.288	−30.905	1.00	53.10	C
ATOM	1722	CD1	LEU	A	222	20.852	−63.895	−31.533	1.00	50.11	C
ATOM	1723	CD2	LEU	A	222	22.219	−65.343	−31.145	1.00	49.10	C
ATOM	1724	C	LEU	A	222	20.492	−66.520	−27.160	1.00	49.41	C
ATOM	1725	O	LEU	A	222	21.458	−66.537	−26.345	1.00	52.76	O
ATOM	1726	N	GLY	A	223	19.213	−66.620	−26.775	1.00	37.97	N
ATOM	1727	CA	GLY	A	223	18.853	−66.437	−25.374	1.00	32.01	C
ATOM	1728	C	GLY	A	223	18.576	−67.705	−24.633	1.00	30.95	C
ATOM	1729	O	GLY	A	223	18.157	−67.563	−23.479	1.00	37.25	O
ATOM	1730	N	GLU	A	224	18.797	−68.345	−25.279	1.00	31.34	N
ATOM	1731	CA	GLU	A	224	18.516	−70.148	−24.649	1.00	31.27	C
ATOM	1732	CB	GLU	A	224	18.448	−71.222	−25.721	1.00	22.02	C
ATOM	1733	CG	GLU	A	224	17.404	−70.345	−26.779	1.00	31.22	C
ATOM	1734	CD	GLU	A	224	15.971	−70.377	−26.227	1.00	32.48	C
ATOM	1735	OE1	GLU	A	224	15.073	−70.320	−26.938	1.00	30.80	O
ATOM	1736	OE2	GLU	A	224	15.737	−71.439	−25.094	1.00	30.01	O
ATOM	1737	C	GLU	A	224	19.590	−70.330	−23.588	1.00	32.08	C
ATOM	1738	O	GLU	A	224	20.720	−70.329	−23.624	1.00	30.91	O
ATOM	1739	N	PRO	A	225	19.210	−71.392	−22.627	1.00	31.78	N
ATOM	1740	CA	PRO	A	225	20.108	−71.323	−21.529	1.00	31.35	C
ATOM	1741	CB	PRO	A	225	19.171	−72.603	−20.583	1.00	28.54	C
ATOM	1742	CG	PRO	A	225	18.033	−73.023	−21.457	1.00	28.62	C
ATOM	1743	CD	PRO	A	225	17.829	−71.398	−22.433	1.00	30.00	C
ATOM	1744	C	PRO	A	225	21.238	−72.148	−21.970	1.00	30.99	C
ATOM	1745	O	PRO	A	225	21.276	−73.910	−21.579	1.00	31.10	O
ATOM	1746	N	ILE	A	226	22.159	−72.240	−22.769	1.00	34.57	N
ATOM	1747	CA	ILE	A	226	23.262	−73.081	−23.212	1.00	35.42	C
ATOM	1748	CB	ILE	A	226	23.839	−72.626	−24.551	1.00	35.10	C
ATOM	1749	CG1	ILE	A	226	22.704	−72.806	−25.562	1.00	32.92	C
ATOM	1750	CD1	ILE	A	226	23.023	−71.716	−26.812	1.00	34.64	C
ATOM	1751	CG2	ILE	A	226	24.819	−73.683	−25.062	1.00	38.03	C
ATOM	1752	C	ILE	A	226	24.307	−73.220	−22.110	1.00	36.00	C
ATOM	1753	O	ILE	A	226	24.899	−72.245	−21.673	1.00	41.18	O
ATOM	1754	N	LYS	A	227	24.474	−74.440	−21.626	1.00	37.18	N
ATOM	1755	CA	LYS	A	227	25.465	−74.728	−20.601	1.00	41.41	C
ATOM	1756	CB	LYS	A	227	24.881	−75.627	−19.507	1.00	43.21	C
ATOM	1757	CG	LYS	A	227	24.143	−74.877	−18.412	1.00	47.10	C
ATOM	1758	CD	LYS	A	227	24.891	−73.619	−17.999	1.00	51.44	C
ATOM	1759	CE	LYS	A	227	24.308	−73.001	−16.735	1.00	58.01	C
ATOM	1760	NZ	LYS	A	227	25.168	−71.196	−16.214	1.00	57.97	N
ATOM	1761	C	LYS	A	227	26.723	−75.368	−21.167	1.00	39.70	C
ATOM	1762	O	LYS	A	227	27.773	−75.301	−20.543	1.00	44.10	O
ATOM	1763	N	ALA	A	228	76.618	−76.002	−22.334	1.00	38.39	N
ATOM	1764	CA	ALA	A	228	27.788	−76.622	−22.966	1.00	37.92	C
ATOM	1765	CA	ALA	A	228	27.963	−78.068	−22.526	1.00	33.72	C
ATOM	1766	C	ALA	A	228	27.682	−76.551	−24.458	1.00	38.26	C
ATOM	1767	O	ALA	A	228	26.582	−76.532	−24.998	1.00	37.63	O
ATOM	1768	N	ALA	A	229	28.836	−76.510	−25.121	1.00	36.09	N
ATOM	1769	CA	ALA	A	229	26.919	−76.651	−26.578	1.00	34.45	C
ATOM	1770	CB	ALA	A	229	29.406	−75.366	−27.205	1.00	35.38	C
ATOM	1771	C	ALA	A	229	29.831	−77.817	−26.960	1.00	38.32	C
ATOM	1772	O	ALA	A	229	30.971	−77.920	−26.488	1.00	40.01	O
ATOM	1773	N	ILE	A	230	29.317	−78.702	−27.803	1.00	42.50	N
ATOM	1774	CA	ILE	A	230	30.009	−79.937	−28.158	1.00	40.75	C
ATOM	1775	CB	ILE	A	230	29.043	−81.121	−28.171	1.00	37.16	C
ATOM	1776	CG1	ILE	A	230	28.691	−81.498	−26.740	1.00	39.26	C
ATOM	1777	CD1	ILE	A	230	27.357	−82.225	−26.606	1.00	39.55	C
ATOM	1778	CG2	ILE	A	230	29.654	−82.235	−28.830	1.00	36.77	C
ATOM	1779	C	ILE	A	230	30.726	−79.777	−29.496	1.00	44.35	C
ATOM	1780	O	ILE	A	230	30.107	−79.442	−30.504	1.00	45.35	O
ATOM	1781	N	LEU	A	231	32.042	−79.595	−29.482	1.00	45.53	N
ATOM	1782	CA	LEU	A	231	32.893	−79.808	−30.676	1.00	43.52	C
ATOM	1783	CB	LEU	A	231	34.045	−78.863	−30.362	1.00	40.56	C
ATOM	1784	CG	LEU	A	231	33.610	−77.543	−29.726	1.00	40.18	C
ATOM	1785	CD1	LEU	A	231	34.806	−76.715	−29.310	1.00	43.09	C
ATOM	1786	CD2	LEU	A	231	32.748	−76.749	−30.691	1.00	40.21	C
ATOM	1787	C	LEU	A	231	33.437	−81.144	−31.100	1.00	41.46	C
ATOM	1788	G	LEU	A	231	34.284	−81.696	−30.416	1.00	42.94	O
ATOM	1789	N	PRO	A	232	32.917	−81.707	−32.207	1.00	43.89	N
ATOM	1790	CA	PRO	A	232	33.474	−82.962	−32.707	1.00	44.44	C
ATOM	1791	CB	PRO	A	232	32.466	−83.398	−33.782	1.00	43.93	C
ATOM	1792	CG	PRO	A	232	31.250	−82.586	−33.532	1.00	48.95	C
ATOM	1793	CD	PRO	A	232	31.767	−81.277	−33.003	1.00	46.26	C
ATOM	1794	C	PRO	A	232	34.839	−82.720	−33.333	1.00	41.40	C
ATOM	1795	O	PRO	A	232	35.073	−81.681	−33.968	1.00	39.17	O
ATOM	1796	N	THR	A	233	35.743	−83.668	−33.159	1.00	42.40	N
ATOM	1797	CA	THR	A	233	37.072	−33.532	−33.773	1.00	42.68	C
ATOM	1798	CB	THR	A	233	37.967	−84.715	−33.409	1.00	39.37	C
ATOM	1799	CG1	THR	A	733	37.268	−85.937	−33.673	1.00	40.59	O
ATOM	1800	CG2	THR	A	233	38.316	−84.649	−31.926	1.00	36.65	C
ATOM	1801	C	THR	A	233	36.957	−83.303	−35.290	1.00	43.74	C
ATOM	1802	O	THR	A	233	37.670	−82.465	−35.837	1.00	42.48	O
ATOM	1803	N	SER	A	234	36.013	−84.011	−35.926	1.00	44.73	N
ATOM	1804	CA	SER	A	234	35.598	−83.817	−37.336	1.00	47.07	C
ATOM	1805	CB	SER	A	234	34.176	−84.358	−37.544	1.00	50.31	C
ATOM	1806	CG	SER	A	234	34.088	−85.724	−37.216	1.00	60.95	O
ATOM	1807	C	SER	A	234	35.555	−82.400	−37.907	1.00	50.45	C
ATOM	1808	O	SER	A	234	35.598	−82.234	−39.133	1.00	51.24	O
ATOM	1809	N	ILE	A	235	35.394	−81.380	−37.067	1.00	49.02	N
ATOM	1810	CA	ILE	A	235	35.112	−80.050	−37.619	1.00	51.95	C
ATOM	1811	CB	ILE	A	235	33.957	−79.318	−36.890	1.00	50.52	C
ATOM	1812	CG1	ILE	A	235	34.422	−78.790	−35.533	1.00	55.67	C
ATOM	1813	CD1	ILE	A	235	33.521	−77.729	−34.946	1.00	55.20	C
ATOM	1814	CG2	ILE	A	235	32.761	−80.235	−36.734	1.00	45.70	C
ATOM	1815	C	ILE	A	235	36.358	−79.191	−37.689	1.00	52.59	O
ATOM	1816	O	ILE	A	235	36.373	−78.143	−38.340	1.00	55.90	N
ATOM	1817	N	PHE	A	236	37.410	−79.646	−37.024	1.00	57.17	C
ATOM	1818	C	PHE	A	236	36.676	−76.930	−37.047	1.00	56.14	C
ATOM	1819	CB	PHE	A	236	39.578	−79.412	−35.924	1.00	51.41	C
ATOM	1820	CG	PHE	A	236	39.106	−79.005	−34.566	1.00	49.55	C
ATOM	1821	CD1	PHE	A	236	38.107	−79.729	−33.913	1.00	48.56	C
ATOM	1822	CE1	PHE	A	236	37.667	−79.351	−32.651	1.00	47.35	C
ATOM	1823	CZ	PHE	A	236	38.229	−78.249	−32.023	1.00	47.28	C
ATOM	1824	CE2	PHE	A	236	39.230	−77.519	−32.658	1.00	48.00	C
ATOM	1825	CD2	PHE	A	236	39.663	−77.897	−33.925	1.00	49.63	C
ATOM	1826	C	PHE	A	236	39.362	−79.125	−38.381	1.00	58.52	C
ATOM	1827	O	PHE	A	236	39.364	−80.214	−38.948	1.00	61.95	O
ATOM	1828	N	LEU	A	237	39.912	−78.035	−38.884	1.00	61.49	N
ATOM	1829	CA	LEU	A	237	40.749	−78.060	−40.061	1.00	64.49	C
ATOM	1830	CB	LEU	A	237	40.584	−76.741	−40.825	1.00	64.59	C
ATOM	1831	CG	LEU	A	237	39.364	−76.478	−41.718	1.00	63.64	C
ATOM	1832	CD1	LEU	A	237	38.040	−76.818	−41.057	1.00	66.77	C
ATOM	1833	CD2	LEU	A	237	39.361	−75.023	−42.153	1.00	64.73	C
ATOM	1834	C	LEU	A	237	42.204	−78.260	−39.594	1.00	72.35	C
ATOM	1835	O	LEU	A	237	42.465	−78.404	−38.390	1.00	66.20	O
ATOM	1836	N	THR	A	238	43.139	−78.276	−40.543	1.00	77.72	N
ATOM	1837	CA	THR	A	238	44.566	−78.443	−40.242	1.00	79.47	C
ATOM	1838	CB	THR	A	238	45.110	−79.730	−40.886	1.00	76.25	C
ATOM	1839	OG1	THR	A	238	44.037	−80.665	−41.079	1.00	74.86	O
ATOM	1840	CG2	THR	A	238	46.190	−80.347	−40.010	1.00	71.93	C
ATOM	1841	C	THR	A	238	45.375	−77.251	−40.763	1.00	79.21	C
ATOM	1842	O	THR	A	238	45.183	−76.820	−41.900	1.00	82.33	O
ATOM	1843	N	ASN	A	239	46.269	−76.707	−39.943	1.00	80.05	N
ATOM	1844	CA	ASN	A	239	47.133	−75.625	−40.420	1.00	84.03	C
ATOM	1845	CB	ASN	A	239	47.415	−74.567	−39.324	1.00	79.55	C
ATOM	1846	CG	ASN	A	239	48.361	−75.054	−38.228	1.00	80.65	C
ATOM	1847	OD1	ASN	A	239	48.606	−76.251	−38.076	1.00	80.17	O
ATOM	1848	ND2	ASN	A	239	48.889	−74.110	−37.445	1.00	76.68	N
ATOM	1849	C	ASN	A	239	43.406	−76.152	−41.107	1.00	92.95	C
ATOM	1850	O	ASN	A	239	48.526	−77.359	−41.372	1.00	88.12	O
ATOM	1851	N	LYS	A	240	49.332	−75.244	−41.415	1.00	102.59	N
ATOM	1852	CA	LYS	A	240	50.606	−75.599	−42.045	1.00	103.12	C
ATOM	1853	CB	LYS	A	240	51.452	−74.342	−42.326	1.00	113.09	C
ATOM	1854	CG	LYS	A	240	51.724	−73.444	−41.117	1.00	121.32	C
ATOM	1855	CD	LYS	A	240	51.949	−71.985	−41.503	1.00	121.07	C
ATOM	1856	CE	LYS	A	240	50.639	−71.207	−41.554	1.00	123.36	C
ATOM	1857	NZ	LYS	A	240	50.864	−69.737	−41.488	1.00	107.84	N
ATOM	1858	C	LYS	A	240	51.378	−76.638	−41.224	1.00	98.30	C
ATOM	1859	O	LYS	A	240	51.745	−77.687	−41.743	1.00	101.69	O
ATOM	1860	N	LYS	A	241	51.579	−76.361	−39.939	1.00	94.24	N
ATOM	1861	CA	LYS	A	241	52.335	−77.250	−39.054	1.00	94.93	C
ATOM	1862	CB	LYS	A	241	52.982	−76.453	−37.910	1.00	96.09	C
ATOM	1863	CG	LYS	A	241	53.991	−75.401	−38.355	1.00	98.55	C
ATOM	1864	CD	LYS	A	241	54.717	−74.777	−37.168	1.00	105.95	C
ATOM	1865	CE	LYS	A	241	53.915	−73.665	−36.505	1.00	107.69	C
ATOM	1866	NZ	LYS	A	241	53.892	−72.421	−37.325	1.00	110.41	N
ATOM	1867	C	LYS	A	241	51.489	−78.401	−38.492	1.00	95.15	C
ATOM	1888	O	LYS	A	241	51.848	−78.996	−37.472	1.00	93.09	O
ATOM	1899	N	GLY	A	242	50.366	−78.694	−39.152	1.00	94.82	N
ATOM	1870	CA	GLY	A	242	49.507	−79.837	−38.811	1.00	92.08	C
ATOM	1871	C	GLY	A	242	48.680	−79.813	−37.526	1.00	86.38	C
ATOM	1872	O	GLY	A	242	48.005	−80.800	−37.213	1.00	79.57	O
ATOM	1873	N	PHE	A	243	48.741	−78.709	−36.780	1.00	88.07	N
ATOM	1874	CA	PHE	A	243	47.908	−78.505	−35.583	1.00	91.03	C
ATOM	1875	CB	PHE	A	243	48.341	−77.228	−34.840	1.00	106.28	C
ATOM	1876	CG	PHE	A	243	49.432	−77.436	−33.810	1.00	119.36	C
ATOM	1877	CD1	PHE	A	243	49.146	−78.009	−37.566	1.00	175.59	C
ATOM	1878	CE1	PHE	A	243	50.142	−78.187	−31.612	1.00	124.27	C
ATOM	1879	CZ	PHE	A	243	51.437	−77.774	−31.885	1.00	124.84	C
ATOM	1880	CE2	PHE	A	243	51.734	−77.286	−33.109	1.00	124.57	C
ATOM	1881	CD2	PHE	A	243	50.737	−77.014	−34.062	1.00	122.67	C
ATOM	1882	C	PHE	A	243	46.410	−78.405	−35.948	1.00	83.61	C
ATOM	1883	O	PHE	A	243	46.071	−77.963	−37.058	1.00	79.88	O
ATOM	1884	N	PRO	A	244	45.506	−78.840	−35.034	1.00	76.70	N
ATOM	1885	CA	PRO	A	244	44.069	−78.592	−35.254	1.00	68.42	C
ATOM	1886	CB	PRO	A	244	43.387	−79.528	−34.247	1.00	66.30	C
ATOM	1887	CG	PRO	A	244	44.424	−79.834	−33.222	1.00	65.69	C
ATOM	1888	CD	PRO	A	244	45.728	−79.322	−33.954	1.00	71.90	C
ATOM	1889	C	PRO	A	244	43.658	−77.128	−35.014	1.00	61.59	C
ATOM	1890	O	PRO	A	244	44.077	−76.527	−34.022	1.00	60.97	O
ATOM	1891	N	VAL	A	245	42.873	−76.373	−35.944	1.00	56.09	N
ATOM	1892	CA	VAL	A	245	42.312	−75.209	−35.863	1.00	55.09	C
ATOM	1893	CB	VAL	A	245	43.167	−74.256	−36.637	1.00	56.09	C
ATOM	1894	CG1	VAL	A	245	44.547	−73.989	−36.019	1.00	56.45	C
ATOM	1895	CG2	VAL	A	245	43.276	−74.487	−38.124	1.00	49.87	C
ATOM	1896	C	VAL	A	245	40.870	−75.209	−36.415	1.00	56.93	C
ATOM	1897	O	VAL	A	245	40.353	−76.264	−36.792	1.00	54.40	O
ATOM	1898	N	LEU	A	246	40.241	−74.030	−36.480	1.00	58.58	N
ATOM	1899	CA	LEU	A	246	38.844	−73.886	−36.943	1.00	55.94	C
ATOM	1900	CB	LEU	A	246	37.913	−73.603	−35.754	1.00	54.60	C
ATOM	1901	CG	LEU	A	246	37.653	−74.679	−34.698	1.00	53.24	C
ATOM	1902	CD1	LEU	A	246	37.079	−74.076	−33.415	1.00	47.55	C
ATOM	1903	CD2	LEU	A	246	36.753	−75.760	−35.268	1.00	51.11	C
ATOM	1904	C	LEU	A	246	38.641	−72.776	−37.988	1.00	56.27	C
ATOM	1905	O	LEU	A	246	39.333	−71.753	−37.961	1.00	62.54	O
ATOM	1906	N	SER	A	247	37.675	−72.973	−38.882	1.00	52.73	N
ATOM	1907	CA	SER	A	247	37.282	−71.962	−39.869	1.00	54.33	C
ATOM	1908	CB	SER	A	247	36.042	−72.432	−40.625	1.00	54.28	C
ATOM	1909	OG	SER	A	247	34.872	−71.909	−40.023	1.00	52.78	O
ATOM	1910	C	SER	A	247	36.941	−70.641	−39.201	1.00	54.58	C
ATOM	1911	O	SER	A	247	36.460	−70.634	−38.067	1.00	54.41	O
ATOM	1912	N	LYS	A	248	37.156	−69.534	−39.911	1.00	98.75	N
ATOM	1913	CA	LYS	A	248	36.830	−68.195	−39.384	1.00	66.78	C
ATOM	1914	CB	LYS	A	248	36.929	−67.105	−40.475	1.00	69.86	C
ATOM	1915	CG	LYS	A	248	38.296	−66.920	−41.139	1.00	73.70	C
ATOM	1916	CD	LYS	A	248	39.400	−66.505	−40.167	1.00	76.63	C
ATOM	1917	CE	LYS	A	248	39.411	−65.006	−39.880	1.00	81.27	C
ATOM	1918	NZ	LYS	A	248	40.475	−64.638	−38.897	1.00	74.54	N
ATOM	1919	C	LYS	A	248	35.433	−68.171	−38.750	1.00	66.96	C
ATOM	1920	G	LYS	A	248	35.255	−67.690	−37.677	1.00	67.39	O
ATOM	1921	N	MET	A	249	34.455	−68.711	−39.476	1.00	63.97	N
ATOM	1922	CA	MET	A	249	33.080	−68.780	−39.007	1.00	62.96	C
ATOM	1923	CB	MET	A	249	32.174	−69.451	−40.050	1.00	71.00	C
ATOM	1924	CG	MET	A	249	31.923	−68.593	−41.295	1.00	84.64	C
ATOM	1925	SD	MET	A	249	31.265	−66.913	−41.023	1.00	97.53	S
ATOM	1926	CE	MET	A	249	32.724	−65.919	−40.655	1.00	86.77	C
ATOM	1927	C	MET	A	249	33.964	−69.448	−37.647	1.00	57.77	C
ATOM	1928	G	MET	A	249	32.474	−68.835	−36.706	1.00	60.03	O
ATOM	1929	N	HIS	A	250	33.436	−70.688	−37.547	1.00	34.08	N
ATOM	1930	CA	HIS	A	250	33.481	−71.404	−36.282	1.00	48.57	C
ATOM	1931	CB	HIS	A	250	34.169	−72.746	−36.447	1.00	44.66	C
ATOM	1932	CG	HIS	A	250	33.371	−73.754	−37.217	1.00	42.87	C
ATOM	1933	ND1	HIS	A	250	33.212	−73.692	−38.586	1.00	41.98	N
ATOM	1934	CE1	HIS	A	250	32.490	−74.724	−38.992	1.00	41.68	C
ATOM	1935	NE2	HIS	A	250	32.173	−75.455	−37.936	1.00	41.32	N
ATOM	1936	CD2	HIS	A	250	32.716	−74.872	−36.814	1.00	41.61	C
ATOM	1937	C	HIS	A	250	34.159	−70.612	−35.166	1.00	53.44	C
ATOM	1938	O	HIS	A	250	33.746	−70.710	−34.016	1.00	62.63	O
ATOM	1939	N	GLN	A	251	35.179	−69.819	−35.484	1.00	53.86	N
ATOM	1940	CA	GLN	A	251	35.806	−68.986	−34.457	1.00	55.47	C
ATOM	1941	CB	GLN	A	251	37.082	−68.313	−34.962	1.00	60.37	C
ATOM	1942	CG	GLN	A	251	38.101	−69.237	−35.628	1.00	65.30	C
ATOM	1943	CD	GLN	A	251	39.355	−68.490	−36.060	1.00	64.59	C
ATOM	1044	OC1	GLN	A	251	40.197	−68.152	−35.234	1.00	65.90	O
ATOM	1945	NE2	GLN	A	251	39.475	−68.219	−37.354	1.00	64.44	N
ATOM	1946	C	GLN	A	251	34.819	−67.933	−33.950	1.00	57.71	C
ATOM	1947	O	GLN	A	251	34.626	−67.789	−32.732	1.00	58.12	O
ATOM	1948	N	ARG	A	252	34.175	−67.222	−34.879	1.00	58.59	N
ATOM	1949	CA	ARG	A	252	33.119	−66.263	−34.522	1.00	59.00	C
ATOM	1950	CB	ARG	A	252	32.366	−65.745	−35.759	1.00	66.80	C
ATOM	1951	CG	ARG	A	252	32.940	−64.466	−36.379	1.00	76.35	C
ATOM	1952	CD	ARG	A	252	32.103	−63.936	−37.547	1.00	84.79	C
ATOM	1953	NE	ARG	A	252	30.701	−63.679	−37.180	1.00	92.34	N
ATOM	1954	CZ	ARG	A	252	29.668	−63.672	−38.031	1.00	93.57	C
ATOM	1955	NH1	ARG	A	252	29.841	−63.908	−39.331	1.00	89.36	N
ATOM	1956	NH2	ARG	A	252	28.444	−63.436	−37.574	1.00	91.23	N
ATOM	1957	C	ARG	A	252	32.152	−66.878	−33.515	1.00	55.53	C
ATOM	1958	O	ARG	A	252	31.893	−66.298	−32.458	1.00	58.09	O
ATOM	1959	N	LEU	A	253	31.650	−68.069	−33.826	1.00	51.71	N
ATOM	1960	CA	LEU	A	253	30.688	−68.734	−32.953	1.00	50.86	C
ATOM	1961	CB	LEU	A	253	30.111	−69.993	−33.610	1.00	48.22	C
ATOM	1962	CG	LEU	A	253	29.133	−70.876	−32.805	1.00	47.32	C
ATOM	1963	CD1	LEU	A	253	27.955	−70.074	−32.275	1.00	46.75	C
ATOM	1964	CD2	LEU	A	253	28.631	−72.070	−33.601	1.00	41.03	C
ATOM	1965	C	LEU	A	253	31.301	−69.052	−31.597	1.00	52.12	C
ATOM	1966	O	LEU	A	253	30.662	−68.856	−30.567	1.00	55.71	O
ATOM	1967	N	ILE	A	254	32.543	−69.521	−31.594	1.00	52.88	N
ATOM	1968	CA	ILE	A	254	33.212	−69.832	−30.343	1.00	51.47	C
ATOM	1969	CB	ILE	A	254	34.630	−70.413	−30.554	1.00	49.65	C
ATOM	1970	CG1	ILE	A	254	34.574	−71.703	−31.382	1.00	46.18	C
ATOM	1971	CD1	ILE	A	254	33.874	−72.862	−30.716	1.00	45.31	C
ATOM	1972	CG2	ILE	A	254	35.327	−70.637	−29.216	1.00	45.02	C
ATOM	1973	C	ILE	A	254	33.274	−68.572	−29.502	1.00	50.70	C
ATOM	1974	O	ILE	A	254	32.914	−68.588	−28.320	1.00	47.68	O
ATOM	1975	N	PHE	A	255	33.706	−67.480	−30.127	1.00	55.22	N
ATOM	1976	CA	PHE	A	255	33.793	−66.181	−29.440	1.00	59.92	C
ATOM	1977	CB	PHE	A	255	34.346	−65.095	−30.372	1.00	64.40	C
ATOM	1978	CG	PHE	A	255	35.829	−65.212	−30.640	1.00	71.44	C
ATOM	1979	CD1	PHE	A	255	36.759	−65.092	−29.601	1.00	78.19	C
ATOM	1980	CE1	PHE	A	255	38.124	−65.192	−29.850	1.00	77.35	C
ATOM	1981	CZ	PHE	A	255	38.579	−65.401	−31.145	1.00	73.21	C
ATOM	1982	CE2	PHE	A	255	37.669	−65.513	−32.187	1.00	73.49	C
ATOM	1983	CD2	PHE	A	255	35.304	−65.414	−31.935	1.00	72.11	C
ATOM	1984	C	PHE	A	255	32.454	−65.750	−28.816	1.00	54.79	C
ATOM	1985	O	PHE	A	255	32.423	−65.766	−27.678	1.00	51.84	O
ATOM	1986	N	ARG	A	256	31.360	−65.953	−29.551	1.00	51.90	N
ATOM	1987	CA	ARG	A	256	30.016	−65.719	−29.015	1.00	54.39	C
ATOM	1988	CB	ARG	A	256	28.940	−65.943	−30.088	1.00	59.07	C
ATOM	1989	CG	ARG	A	256	28.816	−64.838	−31.139	1.00	64.35	C
ATOM	1990	CD	ARG	A	256	27.718	−63.843	−30.765	1.00	67.70	C
ATOM	1991	NE	ARG	A	256	26.801	−63.577	−31.886	1.00	70.43	N
ATOM	1992	CZ	ARG	A	256	25.802	−64.376	−32.276	1.00	68.04	C
ATOM	1993	NH1	ARG	A	256	25.554	−65.533	−31.664	1.00	67.23	N
ATOM	1994	NH2	ARG	A	256	25.046	−64.922	−33.298	1.00	68.29	N
ATOM	1995	C	ARG	A	256	29.766	−66.618	−27.801	1.00	52.37	C
ATOM	1996	O	ARG	A	256	29.310	−66.153	−26.752	1.00	55.21	O
ATOM	1997	N	LEU	A	257	30.103	−67.897	−27.930	1.00	46.30	N
ATOM	1998	CA	LEU	A	257	29.928	−68.833	−26.829	1.00	43.47	C
ATOM	1999	CB	LEU	A	257	30.114	−70.264	−27.323	1.00	44.63	C
ATOM	2000	CG	LEU	A	257	29.050	−70.776	−28.316	1.00	46.23	C
ATOM	2001	CD1	LEU	A	257	29.645	−71.849	−29.216	1.00	43.01	C
ATOM	2002	CD2	LEU	A	257	27.820	−71.328	−27.604	1.00	40.84	C
ATOM	2003	C	LEU	A	257	30.844	−68.530	−25.633	1.00	44.37	C
ATOM	2004	O	LEU	A	257	30.468	−68.765	−24.488	1.00	44.65	O
ATOM	2005	N	LEU	A	258	32.035	−67.990	−25.875	1.00	44.69	N
ATOM	2006	CA	LEU	A	258	32.894	−67.545	−24.744	1.00	47.95	C
ATOM	2007	CB	LEU	A	258	34.307	−67.248	−25.179	1.00	43.95	C
ATOM	2008	CG	LEU	A	258	35.127	−68.455	−25.636	1.00	46.75	C
ATOM	2009	CD1	LEU	A	258	36.183	−68.949	−26.655	1.00	53.34	C
ATOM	2010	CD2	LEU	A	258	35.758	−69.285	−24.454	1.00	48.78	C
ATOM	2011	C	LEU	A	258	32.240	−66.553	−23.924	1.00	49.66	C
ATOM	2012	O	LEU	A	258	32.214	−66.540	−22.697	1.00	50.36	O
ATOM	2013	N	LYS	A	259	31.695	−65.545	−24.615	1.00	56.08	N
ATOM	2014	CA	LYS	A	259	30.928	−64.455	−23.990	1.00	57.96	C
ATOM	2015	CB	LYS	A	259	30.399	−63.495	−25.058	1.00	63.14	C
ATOM	2016	CG	LYS	A	259	31.166	−62.283	−25.170	1.00	68.74	C
ATOM	2017	CD	LYS	A	259	30.502	−61.679	−24.346	1.00	80.95	C
ATOM	2018	CE	LYS	A	259	31.487	−60.291	−23.481	1.00	87.05	C
ATOM	2019	NZ	LYS	A	259	32.560	−59.503	−24.257	1.00	89.35	N
ATOM	2020	C	LYS	A	259	29.786	−64.959	−23.096	1.00	60.25	C
ATOM	2021	O	LYS	A	259	29.467	−64.337	−22.099	1.00	68.02	O
ATOM	2022	N	LEU	A	260	29.205	−66.205	−23.442	1.00	58.51	N
ATOM	2023	CA	LEU	A	260	28.161	−66.734	−22.650	1.00	57.27	C
ATOM	2024	CB	LEU	A	260	27.200	−67.444	−23.603	1.00	56.48	C
ATOM	2025	CG	LEU	A	260	25.746	−67.527	−23.169	1.00	55.15	C
ATOM	2026	CD1	LEU	A	260	25.145	−66.239	−23.067	1.00	54.38	C
ATOM	2027	CD2	LEU	A	260	24.960	−68.867	−24.160	1.00	57.06	C
ATOM	2028	C	LEU	A	260	28.724	−67.740	−21.641	1.00	58.98	C
ATOM	2029	O	LEU	A	260	27.991	−68.396	−20.883	1.00	56.48	O
ATOM	2030	N	GLU	A	261	30.037	−67.883	−21.641	1.00	56.45	N
ATOM	2031	CA	GLU	A	261	30.693	−68.750	−20.670	1.00	56.32	C
ATOM	2032	CB	GLU	A	261	30.749	−68.103	−19.285	1.00	57.14	C
ATOM	2033	CG	GLU	A	261	30.937	−66.596	−19.281	1.00	65.83	C
ATOM	2034	CD	GLU	A	261	30.986	−66.031	−17.871	1.00	75.64	C
ATOM	2035	OE1	GLU	A	261	30.815	−64.799	−17.702	1.00	80.95	O
ATOM	2036	OE2	GLU	A	261	31.197	−66.175	−16.926	1.00	73.20	O
ATOM	2037	C	GLU	A	261	30.043	−70.225	−20.567	1.00	50.82	C
ATOM	2038	O	GLU	A	261	29.661	−70.557	−19.495	1.00	63.15	O
ATOM	2039	N	VAL	A	262	29.942	−70.820	−21.683	1.00	45.13	N
ATOM	2040	CA	VAL	A	262	29.568	−72.210	−21.664	1.00	42.96	C
ATOM	2041	CB	VAL	A	262	78.969	−72.639	−23.009	1.00	42.98	C
ATOM	2042	CG1	VAL	A	262	27.669	−71.906	−23.281	1.00	39.27	C
ATOM	2043	CG2	VAL	A	262	29.960	−72.389	−24.134	1.00	47.78	C
ATOM	2044	C	VAL	A	262	30.812	−73.051	−21.396	1.00	47.75	C
ATOM	2045	O	VAL	A	262	31.944	−72.548	−21.453	1.00	44.51	O
ATOM	2046	N	GLN	A	263	30.601	−74.331	−21.114	1.00	45.31	N
ATOM	2047	CA	GLN	A	263	31.705	−75.267	−21.055	1.00	47.58	C
ATOM	2048	CB	GLN	A	263	31.483	−76.276	−19.936	1.00	46.98	C
ATOM	2049	CG	GLN	A	263	31.722	−75.694	−18.545	1.00	45.76	C
ATOM	2050	CD	GLN	A	263	31.444	−76.710	−17.469	1.00	47.32	C
ATOM	2051	CE1	GLN	A	263	30.325	−77.210	−17.347	1.00	48.21	O
ATOM	2052	NE2	GLN	A	263	32.462	−77.040	−16.693	1.00	47.27	N
ATOM	2053	C	GLN	A	263	31.844	−75.971	−22.402	1.00	51.28	C
ATOM	2054	O	GLN	A	263	30.842	−76.284	−23.051	1.00	53.48	O
ATOM	2055	N	PHE	A	264	33.084	−76.209	−22.831	1.00	53.11	N
ATOM	2056	CA	PHE	A	764	33.321	−76.851	−24.121	1.00	49.88	C
ATOM	2057	CB	PHE	A	264	34.412	−76.140	−24.891	1.00	46.04	C
ATOM	2058	CG	PHE	A	264	34.004	−74.769	−25.350	1.00	44.76	C
ATOM	2059	CD1	PHE	A	264	33.391	−74.593	−26.588	1.00	40.62	C
ATOM	2060	CE1	PHE	A	264	33.007	−73.346	−27.005	1.00	37.92	C
ATOM	2061	CZ	PHE	A	264	33.202	−72.250	−26.183	1.00	38.19	C
ATOM	2062	CE2	PHE	A	264	33.791	−77.403	−74.946	1.00	40.47	C
ATOM	2063	CD2	PHE	A	264	34.190	−73.661	−24.529	1.00	43.13	C
ATOM	2064	C	PHE	A	264	33.617	−78.316	−23.976	1.00	51.86	C
ATOM	2065	O	PHE	A	264	34.261	−78.729	−23.022	1.00	54.60	O
ATOM	2066	N	ILE	A	265	33.102	−79.102	−24.915	1.00	49.99	N
ATOM	2067	CA	ILE	A	265	33.203	−80.539	−24.839	1.00	49.20	C
ATOM	2068	CB	ILE	A	265	31.844	−81.204	−24.524	1.00	49.05	C
ATOM	2069	CG1	ILE	A	265	31.328	−80.837	−23.116	1.00	48.44	C
ATOM	2070	CD1	ILE	A	265	29.905	−81.556	−22.841	1.00	42.10	C
ATOM	2071	CG2	ILE	A	265	31.930	−82.718	−24.706	1.00	47.98	C
ATOM	2072	C	ILE	A	265	33.693	−81.064	−26.173	1.00	49.47	C
ATOM	2073	O	ILE	A	265	33.062	−80.826	−27.201	1.00	49.39	O
ATOM	2074	N	ILE	A	266	34.805	−81.802	−26.132	1.00	48.25	N
ATOM	2075	CA	ILE	A	266	35.367	−82.450	−27.304	1.00	43.97	C
ATOM	2076	CB	ILE	A	266	36.914	−82.467	−27.276	1.00	42.22	C
ATOM	2077	CG1	ILE	A	266	37.495	−81.116	−26.814	1.00	40.96	C
ATOM	2078	CD1	ILE	A	266	37.641	−80.055	−27.876	1.00	41.73	C
ATOM	2079	CG2	ILE	A	266	37.466	−82.934	−28.621	1.00	42.32	C
ATOM	2080	C	ILE	A	266	34.886	−83.896	−27.403	1.00	43.49	C
ATOM	2081	O	ILE	A	266	35.102	−84.705	−26.485	1.00	41.43	O
ATOM	2082	N	THR	A	267	34.282	−84.224	−28.546	1.00	39.69	N
ATOM	2083	CA	THR	A	267	33.771	−85.569	−28.792	1.00	41.29	C
ATOM	2084	CB	THR	A	267	32.231	−85.529	−28.939	1.00	36.46	C
ATOM	2085	OG1	THR	A	267	31.723	−86.850	−29.093	1.00	40.34	O
ATOM	2086	CG2	THR	A	267	31.802	−84.705	−30.141	1.00	33.93	C
ATOM	2087	C	THR	A	267	34.466	−86.190	−30.027	1.00	42.85	C
ATOM	2088	O	THR	A	267	34.950	−85.456	−30.875	1.00	42.40	O
ATOM	2089	N	GLY	A	268	34.512	−87.521	−30.121	1.00	46.41	N
ATOM	2090	CA	GLY	A	268	35.145	−88.204	−31.276	1.00	53.98	C
ATOM	2091	C	GLY	A	268	36.619	−88.577	−31.090	1.00	59.97	C
ATOM	2092	O	GLY	A	268	37.239	−88.152	−30.110	1.00	59.79	O
ATOM	2093	N	THR	A	269	37.191	−89.365	−32.012	1.00	60.76	N
ATOM	2094	CA	THR	A	269	38.618	−89.770	−31.902	1.00	60.88	C
ATOM	2095	CB	THR	A	269	36.962	−91.097	−32.628	1.00	59.65	C
ATOM	2096	OG1	THR	A	269	38.361	−91.114	−33.932	1.00	59.10	O
ATOM	2097	CG2	THR	A	269	38.528	−92.320	−31.819	1.00	61.41	C
ATOM	2098	C	THR	A	269	39.563	−83.708	−32.444	1.00	62.31	C
ATOM	2099	O	THR	A	269	39.140	−87.787	−33.140	1.00	58.97	O
ATOM	2100	N	ASN	A	270	40.848	−88.860	−32.136	1.00	69.16	N
ATOM	2101	CA	ASN	A	270	41.882	−87.991	−32.686	1.00	79.51	C
ATOM	2102	CB	ASN	A	270	43.180	−88.126	−31.888	1.00	80.21	C
ATOM	2103	CG	ASN	A	270	44.271	−87.213	−32.400	1.00	84.75	C
ATOM	2104	OD1	ASN	A	270	43.997	−86.169	−33.002	1.00	83.32	O
ATOM	2105	ND2	ASN	A	270	45.519	−87.600	−32.168	1.00	91.73	N
ATOM	2106	C	ASN	A	270	42.142	−88.281	−34.168	1.00	84.50	C
ATOM	2107	O	ASN	A	270	42.468	−89.411	−34.536	1.00	86.44	O
ATOM	2108	N	HIS	A	271	41.992	−87.259	−35.009	1.00	86.51	N
ATOM	2109	CA	HIS	A	271	42.177	−87.420	−36.451	1.00	93.02	C
ATOM	2110	CB	HIS	A	271	40.954	−86.918	−37.223	1.00	92.02	C
ATOM	2111	CG	HIS	A	271	39.749	−87.798	−37.077	1.00	92.65	C
ATOM	2112	ND1	HIS	A	271	38.486	−87.300	−36.842	1.00	88.60	N
ATOM	2113	CE1	HIS	A	271	37.627	−88.301	−36.759	1.00	91.86	C
ATOM	2114	NE2	HIS	A	271	38.289	−89.433	−36.920	1.00	96.54	N
ATOM	2115	CD2	HIS	A	271	39.619	−89.147	−37.120	1.00	93.69	C
ATOM	2116	C	HIS	A	271	43.472	−86.769	−36.936	1.00	102.68	C
ATOM	2117	O	HIS	A	271	44.042	−87.167	−37.959	1.00	101.52	O
ATOM	2118	N	HIS	A	272	43.931	−85.774	−36.182	1.00	111.60	N
ATOM	2119	CA	HIS	A	272	45.265	−85.211	−36.348	1.00	120.65	C
ATOM	2120	CB	HIS	A	272	45.286	−83.756	−35.881	1.00	122.38	C
ATOM	2121	CG	HIS	A	272	44.264	−82.896	−36.556	1.00	126.93	C
ATOM	2122	ND1	HIS	A	272	42.920	−82.363	−36.258	1.00	127.96	N
ATOM	2123	CE1	HIS	A	272	42.260	−82.098	−37.007	1.00	130.33	C
ATOM	2124	NE2	HIS	A	272	43.128	−81.472	−37.781	1.00	130.68	N
ATOM	2125	CD2	HIS	A	272	44.388	−81.955	−37.521	1.00	130.62	C
ATOM	2126	C	HIS	A	272	46.220	−86.076	−35.529	1.00	125.42	C
ATOM	2127	O	HIS	A	272	46.579	−85.735	−34.396	1.00	131.06	O
ATOM	2128	N	SER	A	273	46.616	−87.201	−36.124	1.00	126.94	N
ATOM	2129	CA	SER	A	273	47.279	−88.302	−35.418	1.00	122.39	C
ATOM	2130	CB	SER	A	273	47.429	−89.500	−36.357	1.00	117.69	C
ATOM	2131	OG	SER	A	273	47.652	−90.687	−35.624	1.00	112.72	O
ATOM	2132	C	SER	A	273	48.630	−87.956	−34.773	1.00	123.01	C
ATOM	2133	O	SER	A	273	48.936	−88.440	−33.678	1.00	118.30	O
ATOM	2134	N	GLU	A	274	49.420	−87.114	−35.445	1.00	124.62	N
ATOM	2135	CA	GLU	A	274	50.750	−86.701	−34.954	1.00	120.75	C
ATOM	2136	CB	GLU	A	274	51.623	−86.137	−36.093	1.00	119.13	C
ATOM	2137	CG	GLU	A	274	51.742	−87.007	−37.347	1.00	113.17	C
ATOM	2138	CD	GLU	A	274	50.692	−86.681	−38.401	1.00	107.49	C
ATOM	2139	OE1	GLU	A	274	50.053	−87.619	−38.920	1.00	101.93	O
ATOM	2140	OE2	GLU	A	274	50.501	−85.486	−38.712	1.00	102.86	O
ATOM	2141	C	GLU	A	274	50.690	−85.585	−33.795	1.00	116.52	C
ATOM	2142	O	GLU	A	274	51.688	−85.024	−33.468	1.00	104.78	O
ATOM	2143	N	LYS	A	275	49.520	−85.664	−33.163	1.00	115.83	N
ATOM	2144	CA	LYS	A	275	49.312	−84.642	−32.044	1.00	113.94	C
ATOM	2145	CB	LYS	A	275	48.596	−83.368	−32.515	1.00	116.81	C
ATOM	2146	CG	LYS	A	275	49.251	−82.614	−33.671	1.00	121.05	C
ATOM	2147	CD	LYS	A	275	50.412	−81.729	−33.220	1.00	121.15	C
ATOM	2148	CE	LYS	A	275	50.792	−80.697	−34.277	1.00	112.20	C
ATOM	2149	NZ	LYS	A	275	51.179	−81.296	−35.585	1.00	105.56	N
ATOM	2150	C	LYS	A	275	48.493	−85.300	−30.931	1.00	112.38	C
ATOM	2151	O	LYS	A	275	47.734	−86.143	−31.174	1.00	108.58	O
ATOM	2152	N	GLU	A	276	48.654	−84.790	−29.713	1.00	109.30	N
ATOM	2153	CA	GLU	A	276	47.868	−85.228	−28.560	1.00	111.55	C
ATOM	2154	CB	GLU	A	276	48.602	−84.134	−27.263	1.00	114.89	C
ATOM	2155	CG	GLU	A	276	47.959	−83.280	−25.948	1.00	119.60	C
ATOM	2156	CD	GLU	A	276	48.137	−86.762	−25.650	1.00	119.68	C
ATOM	2157	OE1	GLU	A	276	48.867	−87.089	−24.682	1.00	120.15	O
ATOM	2158	OE2	GLU	A	276	47.543	−87.600	−26.371	1.00	110.35	O
ATOM	2159	C	GLU	A	276	46.448	−84.627	−28.608	1.00	104.92	C
ATOM	2160	O	GLU	A	276	46.214	−83.636	−29.298	1.00	98.05	O
ATOM	2161	N	PHE	A	277	45.508	−85.139	−27.887	1.00	98.94	N
ATOM	2162	CA	PHE	A	277	44.167	−84.675	−27.707	1.00	96.81	C
ATOM	2163	CB	PHE	A	277	43.303	−85.376	−26.821	1.00	98.90	C
ATOM	2164	CG	PHE	A	277	42.536	−86.621	−27.571	1.00	131.65	C
ATOM	2165	CD1	PHE	A	277	42.887	−87.972	−27.463	1.00	197.66	C
ATOM	2166	CE1	PHE	A	277	42.184	−88.953	−28.149	1.00	195.41	C
ATOM	2167	CZ	PHE	A	277	41.113	−81.585	−78.953	1.00	199.45	C
ATOM	2168	CE2	PHE	A	277	40.750	−87.241	−29.067	1.00	103.53	C
ATOM	2169	CD2	PHE	A	277	41.455	−86.268	−28.375	1.00	96.57	C
ATOM	2170	C	PHE	A	277	44.211	−83.285	−27.077	1.00	93.70	C
ATOM	2171	O	PHE	A	277	43.274	−82.492	−27.242	1.00	94.16	O
ATOM	2172	N	CYS	A	278	45.290	−83.007	−26.346	1.00	81.82	N
ATOM	2173	CA	CYS	A	278	45.469	−81.723	−25.684	1.00	74.52	C
ATOM	2174	CB	CYS	A	278	46.630	−81.785	−24.675	1.00	30.41	C
ATOM	2175	SG	CYS	A	278	48.308	−81.701	−25.354	1.00	83.20	S
ATOM	2176	C	CYS	A	278	45.656	−80.572	−26.686	1.00	69.31	C
ATOM	2177	O	CYS	A	278	45.564	−79.407	−26.317	1.00	68.96	O
ATOM	2178	N	SER	A	279	45.897	−80.904	−27.951	1.00	66.91	N
ATOM	2179	CA	SER	A	279	46.110	−79.901	−28.992	1.00	67.03	C
ATOM	2180	CB	SER	A	279	46.810	−80.523	−30.195	1.00	69.23	C
ATOM	2181	OG	SER	A	279	45.940	−81.447	−30.826	1.00	77.69	O
ATOM	2182	C	SER	A	279	44.803	−79.215	−29.433	1.00	64.40	C
ATOM	2183	O	SER	A	279	44.779	−77.991	−29.614	1.00	66.92	O
ATOM	2184	N	TYR	A	280	43.735	−79.999	−29.619	1.00	58.38	N
ATOM	2185	CA	TYR	A	280	42.381	−79.439	−29.753	1.00	56.80	C
ATOM	2186	CB	TYR	A	280	41.332	−80.536	−29.679	1.00	53.71	C
ATOM	2187	CG	TYR	A	280	41.373	−81.476	−30.839	1.00	53.81	C
ATOM	2188	CD1	TYR	A	280	40.805	−81.122	−32.059	1.00	52.62	C
ATOM	2189	CE1	TYR	A	280	40.838	−81.988	−33.137	1.00	55.93	C
ATOM	2190	CZ	TYR	A	280	41.450	−83.230	−33.001	1.00	58.31	C
ATOM	2191	CH	TYR	A	280	41.483	−84.092	−34.075	1.00	63.55	O
ATOM	2192	CE2	TYR	A	280	42.016	−83.609	−31.794	1.00	56.10	C
ATOM	2193	CD2	TYR	A	280	41.977	−82.729	−30.722	1.00	56.28	C
ATOM	2194	C	TYR	A	280	42.112	−78.436	−28.637	1.00	54.72	C
ATOM	2195	O	TYR	A	280	41.748	−77.286	−28.883	1.00	55.79	O
ATOM	2196	N	LEU	A	281	42.941	−78.884	−27.410	1.00	52.92	N
ATOM	2197	CA	LEU	A	281	42.120	−78.081	−26.236	1.00	54.20	C
ATOM	2198	CB	LEU	A	281	42.418	−78.918	−24.998	1.00	57.45	C
ATOM	2199	CG	LEU	A	281	41.318	−79.135	−23.959	1.00	58.99	C
ATOM	2200	CD1	LEU	A	281	41.816	−80.096	−22.886	1.00	58.82	C
ATOM	2201	CD2	LEU	A	281	40.916	−77.807	−23.339	1.00	64.07	C
ATOM	2202	C	LEU	A	281	42.985	−76.824	−26.276	1.00	57.18	C
ATOM	2203	O	LEU	A	281	42.482	−75.727	−26.051	1.00	57.70	O
ATOM	2204	N	GLN	A	282	44.272	−76.991	−26.593	1.00	60.13	N
ATOM	2205	CA	GLN	A	282	45.240	−75.887	−26.630	1.00	62.11	C
ATOM	2206	CB	GLN	A	282	46.611	−76.382	−27.102	1.00	31.84	C
ATOM	2207	CG	GLN	A	282	47.550	−76.962	−26.046	1.00	29.73	C
ATOM	2208	CD	GLN	A	282	48.857	−77.465	−26.665	1.00	87.66	C
ATOM	2209	CE1	GLN	A	282	48.854	−78.258	−27.615	1.00	86.25	O
ATOM	2210	NE2	GLN	A	282	49.981	−76.988	−26.137	1.00	87.71	N
ATOM	2211	C	GLN	A	282	44.779	−74.801	−27.585	1.00	59.68	C
ATOM	2212	O	GLN	A	282	45.022	−73.617	−27.366	1.00	54.94	O
ATOM	2213	N	TYR	A	283	44.119	−75.216	−28.661	1.00	61.05	N
ATOM	2214	CA	TYR	A	283	43.591	−74.761	−29.620	1.00	62.92	C
ATOM	2215	CB	TYR	A	283	43.108	−74.947	−30.901	1.00	62.02	C
ATOM	2216	CG	TYR	A	283	42.691	−73.946	−31.953	1.00	67.26	C
ATOM	2217	CD1	TYR	A	283	43.632	−73.105	−32.558	1.00	66.91	C
ATOM	2218	CE1	TYR	A	283	43.249	−72.167	−33.506	1.00	67.67	C
ATOM	2219	CZ	TYR	A	283	41.910	−72.065	−33.867	1.00	67.00	C
ATOM	2220	OH	TYR	A	283	41.514	−71.142	−34.815	1.00	63.62	O
ATOM	2221	CE2	TYR	A	283	40.964	−72.890	−33.280	1.00	66.63	C
ATOM	2222	CD2	TYR	A	283	41.354	−73.819	−32.328	1.00	66.08	C
ATOM	2223	C	TYR	A	283	42.484	−73.403	−28.996	1.00	65.06	C
ATOM	2224	O	TYR	A	283	42.493	−72.174	−29.146	1.00	65.17	O
ATOM	2225	N	LEU	A	284	41.556	−74.051	−28.286	1.00	59.97	N
ATOM	2226	CA	LEU	A	284	40.495	−73.348	−27.576	1.00	58.66	C
ATOM	2227	CB	LEU	A	284	39.589	−74.325	−26.836	1.00	59.17	C
ATOM	2228	CG	LEU	A	284	38.724	−75.157	−27.755	1.00	59.17	C
ATOM	2229	CD1	LEU	A	284	37.759	−75.995	−26.934	1.00	61.59	C
ATOM	2230	CD2	LEU	A	284	37.990	−74.226	−28.706	1.00	58.47	C
ATOM	2231	C	LEU	A	284	41.038	−72.342	−26.591	1.00	57.59	C
ATOM	2232	O	LEU	A	384	40.629	−71.178	−26.601	1.00	49.56	O
ATOM	2233	N	GLU	A	285	41.958	−72.791	−25.737	1.00	65.07	N
ATOM	2234	CA	GLU	A	285	42.594	−71.892	−24.768	1.00	72.96	C
ATOM	2235	CB	GLU	A	285	43.479	−72.653	−23.769	1.00	78.09	C
ATOM	2236	CG	GLU	A	285	42.666	−73.149	−22.569	1.00	96.06	C
ATOM	2237	CD	GLU	A	285	43.315	−74.285	−21.786	1.00	103.71	C
ATOM	2238	OE1	GLU	A	285	44.183	−74.996	−22.339	1.00	108.88	O
ATOM	2239	OE2	GLU	A	285	42.937	−74.479	−20.608	1.00	105.48	O
ATOM	2240	C	GLU	A	285	43.319	−70.753	−25.483	1.00	69.45	C
ATOM	2241	O	GLU	A	285	43.374	−69.632	−24.973	1.00	70.26	O
ATOM	2242	N	TYR	A	286	43.811	−71.031	−26.691	1.00	65.64	N
ATOM	2243	CA	TYR	A	286	44.426	−70.004	−27.521	1.00	63.16	C
ATOM	2244	CB	TYR	A	286	45.163	−70.626	−28.726	1.00	60.62	C
ATOM	2245	CG	TYR	A	286	45.402	−69.689	−29.889	1.00	61.69	C
ATOM	2246	CD1	TYR	A	286	46.278	−68.602	−29.779	1.00	64.22	C
ATOM	2247	CE1	TYR	A	286	46.485	−67.734	−30.848	1.00	65.79	C
ATOM	2248	CZ	TYR	A	286	45.823	−67.960	−32.056	1.00	70.27	C
ATOM	2249	OH	TYR	A	286	46.025	−67.115	−33.136	1.00	69.74	O
ATOM	2250	CE2	TYR	A	286	44.959	−69.039	−32.187	1.00	66.61	C
ATOM	2251	CD2	TYR	A	286	44.756	−69.894	−31.109	1.00	62.62	C
ATOM	2252	C	TYR	A	286	43.365	−68.977	−27.925	1.00	61.82	C
ATOM	2253	O	TYR	A	286	43.543	−67.770	−27.696	1.00	61.13	O
ATOM	2254	N	LEU	A	287	42.256	−69.454	−28.488	1.00	58.70	N
ATOM	2255	CA	LEU	A	287	41.137	−68.568	−28.857	1.00	60.85	C
ATOM	2256	CB	LEU	A	287	39.996	−69.377	−29.472	1.00	56.67	C
ATOM	2257	CG	LEU	A	287	39.805	−69.304	−30.989	1.00	56.37	C
ATOM	2258	CD1	LEU	A	287	41.109	−69.249	−31.766	1.00	58.23	C
ATOM	2259	CD2	LEU	A	287	38.968	−70.480	−31.448	1.00	53.86	C
ATOM	2260	C	LEU	A	287	40.620	−67.626	−27.739	1.00	60.14	C
ATOM	2261	O	LEU	A	287	40.410	−66.426	−27.987	1.00	57.06	O
ATOM	2262	N	SER	A	288	40.446	−68.160	−26.526	1.00	59.39	N
ATOM	2263	CA	SER	A	288	39.963	−67.373	−25.375	1.00	63.57	C
ATOM	2264	CB	SER	A	288	39.524	−68.289	−24.234	1.00	64.34	C
ATOM	2265	OG	SER	A	288	40.242	−69.505	−24.283	1.00	66.86	O
ATOM	2266	C	SER	A	288	40.965	−66.357	−24.850	1.00	67.70	C
ATOM	2267	O	SER	A	288	40.588	−65.245	−24.462	1.00	63.20	O
ATOM	2268	N	GLN	A	289	42.239	−66.742	−24.821	1.00	75.47	N
ATOM	2269	CA	GLN	A	289	43.295	−65.805	−24.460	1.00	81.78	C
ATOM	2270	CB	GLN	A	289	44.599	−66.540	−24.167	1.00	88.58	C
ATOM	2271	CG	GLN	A	289	44.660	−67.055	−22.732	1.00	99.92	C
ATOM	2272	CD	GLN	A	289	45.342	−68.412	−22.603	1.00	109.12	C
ATOM	2273	OE1	GLN	A	289	46.309	−68.710	−23.313	1.00	107.93	O
ATOM	2274	NE2	GLN	A	289	44.835	−69.244	−21.686	1.00	108.53	N
ATOM	2275	C	GLN	A	289	43.465	−64.730	−25.528	1.00	80.45	C
ATOM	2276	O	GLN	A	289	43.892	−63.523	−25.233	1.00	77.69	O
ATOM	2277	N	ASN	A	290	43.086	−65.955	−26.759	1.00	86.93	N
ATOM	2278	CA	ASN	A	290	43.137	−64.111	−27.878	1.00	91.52	C
ATOM	2279	CB	ASN	A	290	43.576	−64.324	−29.161	1.00	94.03	C
ATOM	2280	CG	ASN	A	290	45.080	−64.362	−29.326	1.00	99.74	C
ATOM	2281	OD1	ASN	A	290	45.595	−64.559	−30.402	1.00	108.43	O
ATOM	2282	ND2	ASN	A	290	45.795	−65.233	−28.263	1.00	95.42	N
ATOM	2283	C	ASN	A	290	41.833	−63.360	−28.140	1.00	92.01	C
ATOM	2284	O	ASN	A	290	41.581	−62.920	−29.264	1.00	95.17	O
ATOM	2285	N	ARG	A	291	40.993	−63.221	−27.123	1.00	89.73	N
ATOM	2286	CA	ARG	A	291	39.799	−62.409	−27.288	1.00	85.93	C
ATOM	2287	CB	ARG	A	291	38.551	−63.127	−26.755	1.00	80.92	C
ATOM	2288	CG	ARG	A	291	38.301	−63.048	−25.260	1.00	78.11	C
ATOM	2289	CD	ARG	A	291	36.955	−63.589	−24.947	1.00	83.18	C
ATOM	2290	NE	ARG	A	291	36.607	−63.632	−23.529	1.00	84.17	N
ATOM	2291	CZ	ARG	A	291	36.892	−64.578	−22.637	1.00	81.25	C
ATOM	2292	NH1	ARG	A	291	37.540	−65.681	−22.988	1.00	81.24	N
ATOM	2293	NH2	ARG	A	291	36.529	−64.412	−21.377	1.00	89.56	N
ATOM	2294	C	ARG	A	291	40.034	−61.039	−26.648	1.00	86.23	C
ATOM	2295	G	ARG	A	291	40.803	−60.938	−25.689	1.00	83.74	O
ATOM	2296	N	PRO	A	292	39.403	−59.976	−27.193	1.00	88.84	N
ATOM	2297	CA	PRO	A	292	39.617	−58.628	−26.650	1.00	88.12	C
ATOM	2298	CB	PRO	A	292	38.594	−57.767	−27.411	1.00	88.59	C
ATOM	2299	CG	PRO	A	292	37.630	−58.734	−28.024	1.00	91.86	C
ATOM	2300	CD	PRO	A	292	38.434	−59.967	−28.306	1.00	88.45	C
ATOM	2301	C	PRO	A	292	39.340	−58.565	−25.150	1.00	90.58	C
ATOM	2302	O	PRO	A	292	38.317	−59.096	−24.698	1.00	92.33	O
ATOM	2303	N	PRO	A	293	40.244	−57.924	−24.377	1.00	93.30	N
ATOM	2304	CA	PRO	A	293	40.024	−57.823	−22.928	1.00	95.38	C
ATOM	2305	CB	PRO	A	293	41.289	−57.112	−22.424	1.00	94.00	C
ATOM	2306	CG	PRO	A	293	41.785	−56.340	−23.601	1.00	92.70	C
ATOM	2307	CD	PRO	A	293	41.429	−57.158	−24.812	1.00	92.74	C
ATOM	2308	C	PRO	A	293	38.767	−57.000	−22.623	1.00	93.08	C
ATOM	2309	C	PRO	A	293	38.466	−56.040	−23.345	1.00	88.35	O
ATOM	2310	N	PRO	A	294	38.007	−57.389	−21.579	1.00	92.08	N
ATOM	2311	CA	PRO	A	294	36.763	−56.689	−21.260	1.00	90.93	C
ATOM	2312	CB	PRO	A	294	36.278	−57.397	−19.983	1.00	94.68	C
ATOM	2313	CG	PRO	A	294	37.483	−58.075	−19.414	1.00	88.66	C
ATOM	2314	CD	PRO	A	294	38.303	−58.461	−20.608	1.00	93.16	C
ATOM	2315	C	PRO	A	294	36.999	−55.199	−20.991	1.00	89.47	C
ATOM	2316	O	PRO	A	294	37.971	−54.841	−20.319	1.00	89.95	O
ATOM	2317	N	ASN	A	295	36.131	−54.337	−21.523	1.00	83.45	N
ATOM	2318	CA	ASN	A	295	36.222	−52.900	−21.243	1.00	75.80	C
ATOM	2319	CB	ASN	A	295	35.343	−52.085	−22.209	1.00	72.67	C
ATOM	2320	CG	ASN	A	295	33.848	−52.243	−21.944	1.00	70.29	C
ATOM	2321	OD1	ASN	A	295	33.428	−52.632	−20.857	1.00	69.51	O
ATOM	2322	ND2	ASN	A	295	33.039	−51.919	−22.943	1.00	65.33	N
ATOM	2323	C	ASN	A	295	35.900	−52.614	−19.770	1.00	72.63	C
ATOM	2324	O	ASN	A	295	35.627	−53.543	−19.005	1.00	78.41	O
ATOM	2325	N	ALA	A	296	35.928	−51.349	−19.365	1.00	67.15	N
ATOM	2326	CA	ALA	A	296	35.721	−51.012	−17.951	1.00	64.62	C
ATOM	2327	CB	ALA	A	296	36.087	−49.557	−17.692	1.00	60.13	C
ATOM	2328	C	ALA	A	296	34.291	−51.331	−17.452	1.00	66.65	C
ATOM	2329	O	ALA	A	296	34.116	−51.813	−16.321	1.00	63.73	O
ATOM	2330	N	TYR	A	297	33.289	−51.067	−18.302	1.00	63.63	N
ATOM	2331	CA	TYR	A	297	31.891	−51.441	−18.040	1.00	61.27	C
ATOM	2332	CB	TYR	A	297	30.990	−50.993	−19.202	1.00	59.85	C
ATOM	2333	CG	TYR	A	297	29.515	−51.345	−19.066	1.00	59.42	C
ATOM	2334	CD1	TYR	A	297	29.043	−52.628	−19.360	1.00	59.12	C
ATOM	2335	CE1	TYR	A	297	27.694	−52.942	−19.246	1.00	57.30	C
ATOM	2336	CZ	TYR	A	297	26.791	−51.963	−18.851	1.00	56.95	C
ATOM	2337	OH	TYR	A	297	25.455	−52.264	−18.745	1.00	56.63	O
ATOM	2338	CE2	TYR	A	297	27.228	−50.683	−18.568	1.00	56.92	C
ATOM	2339	CD2	TYR	A	297	26.581	−50.382	−18.679	1.00	60.93	C
ATOM	2340	C	TYR	A	297	31.747	−52.945	−17.792	1.00	59.72	C
ATOM	2341	O	TYR	A	297	31.100	−53.351	−16.832	1.00	60.13	O
ATOM	2342	N	GLU	A	298	32.372	−53.753	−18.650	1.00	63.24	N
ATOM	2343	CA	GLU	A	298	32.287	−55.220	−18.581	1.00	66.88	C
ATOM	2344	CB	GLU	A	298	32.837	−55.868	−19.862	1.00	68.80	C
ATOM	2345	CG	GLU	A	298	31.862	−55.874	−21.032	1.00	70.99	C
ATOM	2346	CD	GLU	A	298	32.536	−55.951	−22.401	1.00	77.73	C
ATOM	2347	OE1	GLU	A	298	33.740	−56.301	−22.483	1.00	77.70	O
ATOM	2348	OE2	GLU	A	298	31.848	−55.654	−23.408	1.00	72.34	O
ATOM	2349	C	GLU	A	298	32.969	−55.808	−17.348	1.00	68.02	C
ATOM	2350	O	GLU	A	298	32.598	−56.886	−16.889	1.00	71.88	O
ATOM	2351	N	LEU	A	299	33.960	−55.101	−16.815	1.00	67.86	N
ATOM	2352	CA	LEU	A	299	34.578	−55.491	−15.551	1.00	68.39	C
ATOM	2353	CB	LEU	A	299	33.971	−54.840	−15.398	1.00	74.98	C
ATOM	2354	CG	LEU	A	299	37.304	−55.624	−15.522	1.00	77.69	C
ATOM	2355	CD1	LEU	A	299	37.157	−57.079	−15.964	1.00	74.87	C
ATOM	2356	CD2	LEU	A	299	38.319	−54.885	−16.401	1.00	75.66	C
ATOM	2357	C	LEU	A	299	33.655	−55.153	−14.372	1.00	65.09	C
ATOM	2358	O	LEU	A	299	33.487	−55.956	−13.448	1.00	61.59	O
ATOM	2359	N	PHE	A	300	33.046	−53.969	−14.406	1.00	66.17	N
ATOM	2360	CA	PHE	A	300	32.086	−53.593	−13.359	1.00	65.25	C
ATOM	2361	CB	PHE	A	300	31.614	−52.145	−13.526	1.00	63.23	C
ATOM	2362	CG	PHE	A	300	30.481	−51.772	−12.605	1.00	66.59	C
ATOM	2363	CD1	PHE	A	300	30.736	−51.308	−11.317	1.00	66.21	C
ATOM	2364	CE1	PHE	A	300	29.692	−50.983	−10.460	1.00	64.65	C
ATOM	2365	CZ	PHE	A	300	28.378	−51.120	−10.885	1.00	65.09	C
ATOM	2366	CE2	PHE	A	300	28.108	−51.580	−12.168	1.00	63.46	C
ATOM	2367	CD2	PHE	A	300	29.151	−51.906	−13.018	1.00	65.38	C
ATOM	2368	C	PHE	A	300	30.875	−54.532	−13.327	1.00	60.61	C
ATOM	2369	O	PHE	A	300	30.474	−55.000	−12.275	1.00	59.86	O
ATOM	2370	N	ALA	A	301	30.310	−54.793	−14.500	1.00	61.60	N
ATOM	2371	CA	ALA	A	301	29.052	−55.511	−14.643	1.00	57.48	C
ATOM	2372	CB	ALA	A	301	28.440	−55.177	−15.990	1.00	53.67	C
ATOM	2373	C	ALA	A	301	29.231	−57.511	−14.508	1.00	60.57	C
ATOM	2374	O	ALA	A	301	28.267	−57.768	−14.596	1.00	61.20	O
ATOM	2375	N	LYS	A	302	30.464	−57.431	−14.254	1.00	69.00	N
ATOM	2376	CA	LYS	A	302	30.845	−58.829	−14.406	1.00	74.29	C
ATOM	2377	CB	LYS	A	302	32.340	−59.043	−14.139	1.00	79.58	C
ATOM	2378	CG	LYS	A	302	32.865	−60.369	−14.685	1.00	87.46	C
ATOM	2379	CD	LYS	A	302	32.592	−60.523	−16.181	1.00	87.83	C
ATOM	2380	CE	LYS	A	302	33.173	−61.815	−16.737	1.00	90.01	C
ATOM	2381	NZ	LYS	A	302	34.659	−61.770	−16.827	1.00	81.41	N
ATOM	2382	C	LYS	A	302	30.017	−59.781	−13.567	1.00	66.59	C
ATOM	2383	O	LYS	A	302	29.430	−60.732	−14.104	1.00	68.06	O
ATOM	2384	N	GLY	A	303	29.961	−59.528	−12.265	1.00	56.25	N
ATOM	2385	CA	GLY	A	303	29.218	−60.418	−11.374	1.00	55.43	C
ATOM	2386	C	GLY	A	303	27.692	−60.374	−11.511	1.00	54.01	C
ATOM	2387	O	GLY	A	303	27.006	−61.161	−10.860	1.00	51.71	O
ATOM	2388	N	TYR	A	304	27.172	−59.485	−12.376	1.00	51.07	N
ATOM	2389	CA	TYR	A	304	25.759	−59.094	−12.365	1.00	49.46	C
ATOM	2390	CB	TYR	A	304	25.652	−57.663	−12.294	1.00	51.71	C
ATOM	2391	CG	TYR	A	304	25.971	−57.027	−10.917	1.00	55.21	C
ATOM	2392	CD1	TYR	A	304	25.038	−57.129	−9.891	1.00	55.05	C
ATOM	2393	CE1	TYR	A	304	25.312	−56.568	−8.617	1.00	57.65	C
ATOM	2394	CZ	TYR	A	304	26.534	−56.097	−8.347	1.00	61.67	C
ATOM	2395	OH	TYR	A	304	26.761	−55.653	−7.064	1.00	65.94	O
ATOM	2396	CE2	TYR	A	304	27.499	−55.981	−9.346	1.00	61.98	C
ATOM	2397	CD2	TYR	A	304	27.215	−56.449	−10.627	1.00	57.44	C
ATOM	2398	C	TYR	A	304	24.906	−59.630	−13.509	1.00	48.18	C
ATOM	2399	O	TYR	A	304	23.709	−59.342	−13.585	1.00	48.72	O
ATOM	2400	N	GLU	A	305	25.522	−60.406	−14.392	1.00	46.96	N
ATOM	2401	CA	GLU	A	305	24.891	−60.802	−15.641	1.00	47.79	C
ATOM	2402	CB	GLU	A	305	25.877	−61.369	−16.522	1.00	50.96	C
ATOM	2403	CG	GLU	A	305	26.840	−60.644	−17.271	1.00	58.32	C
ATOM	2404	CD	GLU	A	305	28.232	−61.238	−17.424	1.00	68.14	C
ATOM	2405	OE1	GLU	A	305	28.589	−62.099	−16.590	1.00	74.27	O
ATOM	2406	OE2	GLU	A	305	28.975	−60.845	−18.360	1.00	67.11	O
ATOM	2407	C	GLU	A	305	23.619	−61.384	−15.368	1.00	48.63	C
ATOM	2408	O	GLU	A	305	23.619	−62.341	−14.590	1.00	45.47	O
ATOM	2409	N	ASP	A	306	22.518	−61.226	−15.960	1.00	47.34	N
ATOM	2410	CA	ASP	A	306	21.181	−61.683	−15.673	1.00	46.04	C
ATOM	2411	CB	ASP	A	306	20.951	−62.998	−16.437	1.00	42.38	C
ATOM	2412	CG	ASP	A	306	21.109	−62.835	−17.939	1.00	43.37	C
ATOM	2413	OD1	ASP	A	306	20.857	−61.734	−18.466	1.00	43.80	O
ATOM	2414	OD2	ASP	A	306	21.498	−63.809	−18.608	1.00	46.91	O
ATOM	2415	C	ASP	A	306	20.838	−61.138	−14.171	1.00	41.99	C
ATOM	2416	O	ASP	A	306	19.988	−62.633	−13.813	1.00	44.02	O
ATOM	2417	N	TYR	A	307	21.490	−61.071	−13.304	1.00	39.63	N
ATOM	2418	CA	TYR	A	307	21.060	−60.974	−11.916	1.00	43.34	C
ATOM	2419	CB	TYR	A	307	22.252	−60.631	−11.010	1.00	47.58	C
ATOM	2420	CG	TYR	A	307	21.918	−60.596	−9.540	1.00	55.83	C
ATOM	2421	CD1	TYR	A	307	21.868	−61.775	−8.789	1.00	59.53	C
ATOM	2422	CE1	TYR	A	307	21.548	−61.748	−7.436	1.00	44.55	C
ATOM	2423	CZ	TYR	A	307	21.274	−60.528	−6.816	1.00	68.45	C
ATOM	2424	OH	TYR	A	307	20.955	−60.512	−5.472	1.00	77.24	O
ATOM	2425	CE2	TYR	A	307	21.316	−59.342	−7.535	1.00	62.51	C
ATOM	2426	CD2	TYR	A	307	21.639	−59.381	−8.891	1.00	60.40	C
ATOM	2427	C	TYR	A	307	19.918	−59.943	−11.788	1.00	40.14	C
ATOM	2428	O	TYR	A	307	20.095	−58.756	−12.070	1.00	59.90	O
ATOM	2429	N	LEU	A	308	18.742	−60.393	−11.382	1.00	21.19	N
ATOM	2430	CA	LEU	A	308	17.559	−59.510	−11.342	1.00	36.99	C
ATOM	2431	CB	LEU	A	308	16.284	−60.324	−11.339	1.00	35.41	C
ATOM	2432	CG	LEU	A	308	15.851	−61.180	−12.519	1.00	54.76	C
ATOM	2433	CD1	LEU	A	308	14.511	−61.776	−12.135	1.00	82.18	C
ATOM	2434	CD2	LEU	A	308	15.725	−60.376	−13.797	1.00	82.92	C
ATOM	2435	C	LEU	A	308	17.536	−58.683	−10.084	1.00	99.33	C
ATOM	2436	O	LEU	A	308	17.617	−59.233	−8.980	1.00	38.66	O
ATOM	2437	N	GLN	A	309	17.416	−57.366	−10.230	1.00	40.12	N
ATOM	2438	CA	GLN	A	309	17.259	−56.501	−9.054	1.00	41.68	C
ATOM	2439	CB	GLN	A	309	18.337	−55.426	−9.005	1.00	45.66	C
ATOM	2440	CG	GLN	A	309	19.680	−55.882	−8.481	1.00	57.21	C
ATOM	2441	CD	GLN	A	309	20.786	−55.006	−9.032	1.00	66.75	C
ATOM	2442	OE1	GLN	A	309	21.185	−55.161	−10.198	1.00	70.99	O
ATOM	2443	NE2	GLN	A	309	21.268	−54.053	−8.215	1.00	60.30	N
ATOM	2444	C	GLN	A	309	15.906	−55.815	−9.023	1.00	39.69	C
ATOM	2445	O	GLN	A	309	15.356	−55.409	−10.054	1.00	37.64	O
ATOM	2446	N	ASER	A	310	15.479	−55.489	−7.811	0.50	42.05	N
ATOM	2447	N	BSER	A	310	15.304	−55.855	−7.845	0.50	37.77	N
ATOM	2448	CA	ASER	A	310	14.505	−54.419	−7.019	0.50	44.75	C
ATOM	2449	CA	BSER	A	310	13.868	−55.662	−7.695	0.50	35.27	C
ATOM	2450	CB	ASER	A	310	14.117	−54.334	−6.134	0.50	44.79	C
ATOM	2451	C3	BSER	A	310	13.378	−56.531	−6.534	0.50	35.28	C
ATOM	2452	O2	ASER	A	310	13.627	−55.576	−5.637	0.50	44.38	O
ATOM	2453	O3	BSER	A	310	11.986	−56.420	−6.346	0.50	36.16	O
ATOM	2454	C	ASER	A	310	15.124	−53.080	−8.092	0.50	44.74	C
ATOM	2455	C	BSER	A	310	13.581	−54.190	−7.448	0.50	33.86	C
ATOM	2456	O	ASER	A	310	16.286	−52.784	−7.819	0.50	46.85	O
ATOM	2457	O	BSER	A	310	14.399	−53.496	−6.850	0.50	35.48	O
ATOM	2458	N	APRO	A	311	14.371	−52.276	−8.844	0.50	43.74	N
ATOM	2459	N	BPRO	A	311	12.427	−53.709	−7.914	0.50	33.31	N
ATOM	2460	CA	APRO	A	311	14.976	−50.980	−9.081	0.50	43.37	C
ATOM	2461	CA	BPRO	A	311	12.034	−52.296	−7.851	0.50	33.86	C
ATOM	2462	CB	APRO	A	311	13.948	−50.285	−9.977	0.50	40.91	C
ATOM	2463	CB	BPRO	A	311	10.586	−52.304	−8.356	0.50	35.57	C
ATOM	2464	CG	APRO	A	311	13.277	−51.407	−10.706	0.50	38.58	C
ATOM	2465	CG	BPRO	A	311	10.150	−53.734	−8.290	0.50	34.34	C
ATOM	2466	CD	APRO	A	311	13.164	−52.485	−9.664	0.50	42.19	C
ATOM	2467	CD	BPRO	A	311	11.384	−54.539	−8.537	0.50	34.14	C
ATOM	2468	C	APRO	A	311	15.133	−50.226	−7.758	0.50	46.08	C
ATOM	2469	c	BPRO	A	311	12.092	−51.689	−6.458	0.50	33.46	C
ATOM	2470	O	APRO	A	311	14.349	−50.454	−6.827	0.50	44.33	O
ATOM	2471	O	BPRO	A	311	11.739	−52.329	−5.467	0.50	32.00	O
ATOM	2472	N	ALEU	A	312	16.149	−49.360	−7.669	0.50	44.74	N
ATOM	2473	N	BLEU	A	312	12.540	−50.447	−6.390	0.50	35.65	N
ATOM	2474	CA	ALEU	A	312	16.310	−48.485	−6.511	0.50	42.33	C
ATOM	2475	CA	BLEU	A	312	12.772	−49.803	−5.100	0.50	35.79	C
ATOM	2476	CB	ALEU	A	312	17.629	−47.714	−6.584	0.50	40.90	C
ATOM	2477	CB	BLEU	A	312	14.264	−49.652	−4.855	0.50	36.45	C
ATOM	2478	CG	ALEU	A	312	18.952	−48.388	−6.201	0.50	38.16	C
ATOM	2479	CG	BLEU	A	312	14.920	−48.982	−6.054	0.50	35.83	C
ATOM	2480	CD1	ALEU	A	312	20.058	−47.374	−6.401	0.50	36.05	C
ATOM	2481	CD1	BLEU	A	312	16.354	−49.487	−6.176	0.50	33.01	C
ATOM	2482	CD2	ALEU	A	312	18.963	−48.309	−4.762	0.50	36.61	C
ATOM	2483	CD2	BLEU	A	312	14.101	−49.343	−7.286	0.50	35.75	C
ATOM	2484	C	ALEU	A	312	15.150	−47.198	−6.446	0.50	42.07	C
ATOM	2485	C	BLEU	A	312	12.135	−48.433	−5.013	0.50	32.95	C
ATOM	2486	O	ALEU	A	312	14.653	−47.244	−7.472	0.50	43.89	O
ATOM	2487	O	BLEU	A	312	11.746	−47.340	−6.023	0.50	29.86	O
ATOM	2488	N	AGLN	A	313	14.719	−47.162	−5.241	0.50	42.44	N
ATOM	2489	N	BGLN	A	313	12.078	−47.833	−3.785	0.50	32.01	N
ATOM	2490	CA	AGLN	A	313	13.609	−46.229	−5.069	0.50	45.90	C
ATOM	2491	CA	BGLN	A	313	11.437	−46.571	−3.472	0.50	31.07	C
ATOM	2492	CB	AGLN	A	313	12.316	−47.911	−4.776	0.50	47.26	C
ATOM	2493	CB	BGLN	A	313	10.663	−46.346	−2.169	0.50	31.30	C
ATOM	2494	CG	AGLN	A	313	11.027	−46.721	−4.927	0.50	49.65	C
ATOM	2495	CG	BGLN	A	313	9.718	−48.039	−2.206	0.50	29.24	C
ATOM	2496	CD	AGLN	A	313	9.770	−47.880	−4.764	0.50	51.29	C
ATOM	2497	CD	BGLN	A	313	8.706	−47.905	−3.316	0.50	29.02	C
ATOM	2498	OE1	AGLN	A	313	9.098	−47.938	−3.724	0.50	53.19	O
ATOM	2499	OE1	BGLN	A	313	8.307	−46.792	−3.658	0.50	31.11	O
ATOM	2500	NE2	AGLN	A	313	9.453	−47.369	−5.789	0.50	46.81	N
ATOM	2501	NE2	BGLN	A	313	8.311	−49.023	−3.913	0.50	27.47	N
ATOM	2502	C	AGLN	A	313	13.925	−45.231	−3.947	0.50	43.75	C
ATOM	2503	C	BGLN	A	313	12.428	−45.508	−3.368	0.50	32.20	C
ATOM	2504	O	AGLN	A	313	13.463	−45.897	−2.813	0.50	45.24	O
ATOM	2505	O	BGLN	A	313	13.002	−45.285	−2.299	0.50	32.52	O
ATOM	2506	N	APRO	A	314	14.723	−44.196	−4.261	0.50	41.78	N
ATOM	2507	N	BPRO	A	314	12.628	−44.168	−4.482	0.50	32.07	N
ATOM	2508	CA	APRO	A	314	15.202	−43.262	−3.246	0.50	42.67	C
ATOM	2509	CA	BPRO	A	314	13.604	−43.376	−4.651	0.50	34.29	C
ATOM	2510	CB	APRO	A	314	16.490	−42.712	−3.859	0.50	41.50	C
ATOM	2511	CB	BPRO	A	314	13.256	−43.097	−6.031	0.50	31.95	C
ATOM	2512	CG	APRO	A	314	16.295	−42.133	−5.341	0.50	42.04	C
ATOM	2513	CG	BPRO	A	314	11.910	−43.630	−6.365	0.50	32.15	C
ATOM	2514	CD	APRO	A	314	15.184	−41.423	−5.608	0.50	40.80	C
ATOM	2515	CD	BPRO	A	314	11.866	−44.986	−5.718	0.50	32.21	C
ATOM	2516	C	APRO	A	314	14.247	−42.110	−2.976	0.50	44.32	C
ATOM	2517	C	BPRO	A	314	13.422	−42.577	−3.630	0.50	36.55	C
ATOM	2518	O	APRO	A	314	14.706	−41.012	−2.708	0.50	45.20	O
ATOM	2519	O	BPRO	A	314	14.378	−42.116	−2.999	0.50	37.39	O
ATOM	2520	N	ALEU	A	315	12.939	−42.350	−3.047	0.50	45.62	N
ATOM	2521	N	BLEU	A	315	12.176	−42.157	−3.508	0.50	41.19	N
ATOM	2522	CA	ALEU	A	315	11.955	−41.313	−2.704	0.50	49.06	C
ATOM	2523	CA	BLEU	A	315	11.767	−41.159	−2.548	0.50	43.28	C
ATOM	2524	CB	ALEU	A	315	11.039	−40.990	−3.891	0.50	47.86	C
ATOM	2525	CB	BLEU	A	315	10.397	−40.420	−2.952	0.50	39.63	C
ATOM	2526	CG	ALEU	A	315	10.094	−39.133	−3.592	0.50	46.44	C
ATOM	2527	CG	BLEU	A	315	10.386	−39.948	−4.308	0.50	37.31	C
ATOM	2528	CD1	ALEU	A	315	10.885	−38.578	−3.264	0.50	46.19	C
ATOM	2529	CD1	BLEU	A	315	8.988	−39.440	−4.600	0.50	39.98	C
ATOM	2530	CD2	ALEU	A	315	9.151	−39.584	−4.752	0.50	48.40	C
ATOM	2531	CD2	BLEU	A	315	11.368	−38.100	−4.239	0.50	38.30	C
ATOM	2532	C	ALEU	A	315	11.114	−41.621	−1.452	0.50	49.79	C
ATOM	2533	C	BLEU	A	315	11.622	−41.813	−1.200	0.50	46.35	C
ATOM	2534	O	ALEU	A	315	10.689	−40.104	−0.742	0.50	51.40	O
ATOM	2535	O	BLEU	A	315	12.182	−41.361	−0.196	0.50	45.07	O
ATOM	2536	N	MET	A	316	10.872	−42.905	−1.201	1.00	48.33	N
ATOM	2537	CA	MET	A	316	10.248	−43.376	0.018	1.00	51.87	C
ATOM	2538	CB	MET	A	316	9.007	−44.166	−0.379	1.00	57.01	C
ATOM	2539	CG	MET	A	316	8.335	−45.012	0.670	1.00	63.32	C
ATOM	2540	SD	MET	A	316	6.877	−45.756	−0.098	1.00	79.84	S
ATOM	2541	CE	MET	A	316	5.713	−44.391	0.043	1.00	67.94	C
ATOM	2542	C	MET	A	316	11.227	−44.168	0.885	1.00	49.22	C
ATOM	2543	O	MET	A	316	10.995	−44.340	2.074	1.00	52.35	O
ATOM	2544	N	ASP	A	317	12.320	−44.642	0.290	1.00	47.47	N
ATOM	2545	CA	ASP	A	317	13.436	−45.718	1.056	1.00	45.92	C
ATOM	2546	CB	ASP	A	317	13.972	−46.507	0.428	1.00	49.51	C
ATOM	2547	CG	ASP	A	317	12.977	−47.631	0.406	1.00	13.49	C
ATOM	2548	CD1	ASP	A	317	12.161	−47.776	1.339	1.00	55.89	O
ATOM	2549	CD2	ASP	A	317	13.048	−48.398	−0.570	1.00	58.44	O
ATOM	2550	C	ASP	A	317	14.600	−44.257	0.994	1.00	43.21	C
ATOM	2551	O	ASP	A	317	14.657	−43.373	0.122	1.00	40.48	O
ATOM	2552	N	ASN	A	318	15.562	−44.498	1.875	1.00	39.24	N
ATOM	2553	CA	ASN	A	318	16.831	−43.788	1.874	1.00	37.61	C
ATOM	2554	CB	ASN	A	318	17.108	−43.191	3.267	1.00	38.55	C
ATOM	2555	CG	ASN	A	318	16.262	−41.968	3.566	1.00	40.41	C
ATOM	2556	CD1	ASN	A	318	16.013	−41.115	2.703	1.00	46.60	O
ATOM	2557	ND2	ASN	A	318	15.826	−41.864	4.794	1.00	44.53	N
ATOM	2558	C	ASN	A	318	17.985	−44.695	1.439	1.00	84.86	C
ATOM	2559	C	ASN	A	318	18.226	−45.768	1.996	1.00	84.16	O
ATOM	2560	N	LEU	A	319	18.711	−44.243	0.442	1.00	84.00	N
ATOM	2561	CA	LEU	A	319	19.850	−44.979	−0.065	1.00	83.80	C
ATOM	2562	CB	LEU	A	319	20.404	−44.235	−1.291	1.00	12.24	C
ATOM	2563	CG	LEU	A	319	19.676	−44.429	−2.611	1.00	30.15	C
ATOM	2564	CD1	LEU	A	319	20.331	−43.606	−3.694	1.00	29.22	C
ATOM	2565	CD2	LEU	A	319	19.751	−45.888	−2.992	1.00	19.64	C
ATOM	2566	C	LEU	A	319	20.941	−45.165	1.020	1.00	34.01	C
ATOM	2567	C	LEU	A	319	21.185	−44.275	1.838	1.00	12.14	O
ATOM	2568	N	GLU	A	320	21.560	−46.332	1.033	1.00	35.48	N
ATOM	2569	CA	GLU	A	320	22.676	−46.616	1.927	1.00	42.04	C
ATOM	2570	CB	GLU	A	320	22.899	−48.112	2.018	1.00	45.93	C
ATOM	2571	CG	GLU	A	320	21.748	−48.917	2.592	1.00	54.62	C
ATOM	2572	CD	GLU	A	320	22.053	−50.399	2.520	1.00	64.08	C
ATOM	2573	CE1	GLU	A	320	22.315	−50.904	1.399	1.00	62.97	O
ATOM	2574	CE2	GLU	A	320	22.000	−51.054	3.589	1.00	72.24	O
AIOM	2575	C	GLU	A	320	24.001	−45.975	1.487	1.00	42.67	C
ATOM	2576	O	GLU	A	320	24.264	−45.778	0.297	1.00	44.02	O
ATOM	2577	N	SER	A	321	24.844	−45.691	2.470	1.00	44.26	N
ATOM	2578	CA	SER	A	321	26.147	−45.083	2.244	1.00	45.78	C
ATOM	2579	CB	SER	A	321	26.948	−45.096	3.543	1.00	44.90	C
ATOM	2580	CG	SER	A	321	28.262	−44.665	3.327	1.00	44.99	O
ATOM	2581	C	SER	A	321	26.924	−45.789	1.132	1.00	46.87	C
ATOM	2582	O	5ER	A	321	27.462	−45.122	0.235	1.00	48.24	O
ATOM	2583	N	GLN	A	322	26.954	−47.125	1.172	1.00	44.84	N
ATOM	2584	CA	GLN	A	322	27.722	−47.902	0.190	1.00	45.84	C
AT0M	2585	CB	GLN	A	322	27.969	−49.332	0.660	1.00	49.57	C
ATOM	2586	CG	GLN	A	322	29.204	−49.426	1.540	1.00	55.35	C
ATOM	2587	CD	GLN	A	322	29.502	−50.837	2.003	1.00	63.51	C
ATOM	2588	OE1	GLN	A	322	29.761	−51.734	1.200	1.00	63.16	O
ATOM	2589	NE2	GLN	A	322	29.472	−51.037	3.313	1.00	69.17	N
ATOM	2590	C	GLN	A	322	27.126	−47.884	−1.202	1.00	45.39	C
ATOM	2591	O	GLN	A	322	27.778	−48.300	−2.166	1.00	67.76	O
ATOM	2592	N	THR	A	323	25.904	−47.376	−1.310	1.00	40.42	N
ATOM	2593	CA	THR	A	323	25.234	−47.316	−2.578	1.00	38.84	C
ATOM	2594	CB	THR	A	323	23.717	−47.476	−2.396	1.00	37.19	C
ATOM	2595	OG1	THR	A	323	23.459	−48.832	2.013	1.00	38.57	O
ATOM	2596	CG2	THR	A	323	22.960	−47.170	−3.688	1.00	33.93	C
ATOM	2597	C	THR	A	323	25.610	−46.022	−3.278	1.00	40.45	C
ATOM	2598	O	THR	A	323	25.784	−45.986	−4.492	1.00	42.56	O
ATOM	2599	N	TYR	A	324	25.730	−44.957	−2.503	1.00	40.77	N
ATOM	2600	CA	TYR	A	324	26.274	−43.727	−3.011	1.00	59.85	C
ATOM	2601	CB	TYR	A	324	26.209	−42.643	−1.956	1.00	40.41	C
ATOM	2602	CG	TYR	A	324	24.834	−42.084	−1.663	1.00	38.76	C
ATOM	2603	CD1	TYR	A	324	24.154	−41.302	−2.614	1.00	39.09	C
ATOM	2604	CE1	TYR	A	324	22.891	−40.769	−2.345	1.00	35.79	C
ATOM	2605	C2	TYR	A	324	22.303	−41.003	−1.100	1.00	38.80	C
ATOM	2606	OH	TYR	A	324	21.040	−40.480	−0.823	1.00	44.40	O
ATOM	2607	CE2	TYR	A	324	22.960	−41.763	−0.142	1.00	35.93	C
ATOM	2608	CD2	TYR	A	324	24.218	−42.299	−0.419	1.00	35.69	C
ATOM	2609	C	TYR	A	324	27.730	−43.982	−3.378	1.00	42.60	C
ATOM	2610	O	TYR	A	324	28.190	−43.541	−4.430	1.00	44.36	O
ATOM	2611	N	GLU	A	325	28.444	−44.714	−2.524	1.00	44.20	N
ATOM	2612	CA	GLU	A	325	29.848	−45.005	−2.775	1.00	47.39	C
ATOM	2613	CB	GLU	A	325	30.417	−45.904	−1.703	1.00	47.67	C
ATOM	2614	CG	GLU	A	325	31.894	−46.157	−1.883	1.00	48.73	C
ATOM	2615	CD	GLU	A	325	32.393	−47.297	−1.034	1.00	54.80	C
ATOM	2616	OE1	GLU	A	325	31.619	−48.242	−0.754	1.00	56.84	O
ATOM	2617	OE2	GLU	A	325	33.575	−47.246	−0.649	1.00	56.61	O
ATOM	2618	C	GLU	A	325	30.100	−45.637	−4.148	1.00	52.74	C
ATOM	2619	O	GLU	A	325	30.907	−45.114	−4.925	1.00	53.35	O
ATOM	2620	N	VAL	A	326	29.417	−46.743	−4.458	1.00	54.00	N
ATOM	2621	CA	VAL	A	326	29.688	−47.447	−5.724	1.00	50.97	C
ATOM	2622	CB	VAL	A	326	28.894	−48.774	−5.907	1.00	54.35	C
ATOM	2623	CG1	VAL	A	326	29.347	−49.827	−4.907	1.00	53.29	C
ATOM	2624	CG2	VAL	A	326	27.387	−48.553	−5.808	1.00	54.68	C
ATOM	2625	C	VAL	A	326	29.466	−46.521	−6.919	1.00	49.99	C
ATOM	2626	O	VAL	A	326	30.285	−46.503	−7.837	1.00	46.73	O
ATOM	2627	N	PHE	A	327	28.392	−45.728	−6.875	1.00	46.38	N
ATOM	2628	CA	PHE	A	327	27.998	−44.901	−8.019	1.00	45.43	C
ATOM	2629	CB	PHE	A	327	26.500	−44.555	−8.000	1.00	46.68	C
ATOM	2630	CG	PHE	A	327	25.710	−45.388	−8.795	1.00	49.26	C
ATOM	2631	CD1	PHE	A	327	25.849	−46.533	−9.519	1.00	47.35	C
ATOM	2632	CE1	PHE	A	327	25.140	−47.684	−9.789	1.00	48.85	C
ATOM	2633	CZ	PHE	A	327	24.280	−48.207	−8.829	1.00	48.35	C
ATOM	2634	CE2	PHE	A	327	24.152	−47.587	−7.600	1.00	45.24	C
ATOM	2635	CD2	PHE	A	327	24.861	−46.433	−7.341	1.00	47.54	C
ATOM	2636	C	PHE	A	327	28.762	−43.605	−8.194	1.00	45.41	C
AIOM	2637	O	PHE	A	327	28.837	−43.070	−9.299	1.00	48.11	O
ATOM	2618	N	GLU	A	328	29.329	−43.096	−7.111	1.00	46.70	N
ATOM	2619	CA	GLU	A	328	30.219	−41.931	−7.174	1.00	44.98	C
ATOM	2640	CB	GLU	A	328	30.561	−41.446	−5.756	1.00	41.37	C
ATOM	2641	CG	GLU	A	328	29.428	−40.691	−5.073	1.00	42.54	C
ATOM	2642	CD	GLU	A	328	29.518	−40.693	−3.547	1.00	44.28	C
ATOM	2643	OE1	GLU	A	328	30.521	−41.207	−2.996	1.00	39.63	O
ATOM	2644	OE2	GLU	A	328	28.579	−40.170	−2.893	1.00	38.94	O
ATOM	2645	C	GLU	A	328	31.495	−42.270	−7.962	1.00	45.92	C
ATOM	2646	O	GLU	A	328	32.238	−41.384	−8.369	1.00	43.10	O
ATOM	2647	N	LYS	A	329	31.708	−43.562	−8.200	1.00	47.24	N
ATOM	2648	CA	LYS	A	329	32.926	−44.059	−8.826	1.00	52.52	C
ATOM	2649	CB	LYS	A	329	33.216	−45.482	−8.324	1.00	56.02	C
ATOM	265O	CG	LYS	A	329	34.684	−45.301	−8.064	1.00	66.22	C
ATOM	2651	CD	LYS	A	329	34.975	−47.811	−8.157	1.00	79.40	C
ATOM	2652	CE	LYS	A	329	35.156	−47.320	−9.597	1.00	73.39	C
ATOM	2653	NZ	LYS	A	329	34.846	−49.370	−9.774	1.00	62.93	N
ATOM	2654	C	LYS	A	329	32.840	−44.009	−10.370	1.00	52.87	C
ATOM	2655	O	LYS	A	329	33.788	−44.892	−11.076	1.00	54.12	O
ATOM	2656	N	ASP	A	330	31.719	−43.526	−10.892	1.00	45.74	N
ATOM	2657	CA	ASP	A	330	31.524	−43.462	−12.337	1.00	49.42	C
ATOM	2658	CB	ASP	A	330	30.042	−43.376	−12.653	1.00	46.46	C
ATOM	2659	CG	ASP	A	330	29.710	−43.546	−14.101	1.00	49.08	C
ATOM	2660	OD1	ASP	A	330	30.364	−42.949	−14.984	1.00	47.34	O
ATOM	2661	OD2	ASP	A	330	28.763	−44.828	−14.355	1.00	46.51	O
ATOM	2662	C	ASP	A	330	32.368	−42.840	−12.969	1.00	52.07	C
ATOM	2663	O	ASP	A	330	32.286	−41.188	−12.555	1.00	52.16	O
ATOM	2664	N	PRO	A	331	33.199	−42.374	−13.971	1.00	57.13	N
ATOM	2665	CA	PRO	A	331	33.969	−41.550	−14.506	1.00	63.51	C
ATOM	2666	CB	PRO	A	331	34.931	−42.211	−15.458	1.00	63.52	C
ATOM	2667	CG	PRO	A	331	34.803	−43.701	−15.306	1.00	63.05	C
ATOM	2668	CD	PRO	A	331	33.459	−41.936	−14.589	1.00	58.51	C
ATOM	2669	C	PRO	A	331	33.048	−40.592	−15.262	1.00	51.78	C
ATOM	2670	O	PRO	A	331	32.898	−39.414	−14.883	1.00	57.85	O
ATOM	2671	N	ILE	A	332	32.373	−41.142	−16.261	1.00	53.53	N
ATOM	2672	CA	ILE	A	332	31.688	−40.364	−17.275	1.00	48.92	C
ATOM	2673	CB	ILE	A	332	31.362	−41.243	−18.506	1.00	48.77	C
ATOM	2674	CG1	ILE	A	332	32.478	−42.290	−18.736	1.00	47.89	C
ATOM	7675	CD1	ILE	A	332	33.872	−41.762	−19.123	1.00	52.14	C
ATOM	2676	CG2	ILE	A	332	31.209	−40.378	−19.751	1.00	53.43	C
ATOM	2677	C	ILE	A	332	30.476	−39.557	−16.772	1.00	47.35	C
ATOM	2678	O	ILE	A	332	30.266	−38.425	−17.232	1.00	44.32	O
AIOM	2679	N	LYS	A	333	29.708	−40.093	−15.814	1.00	42.58	N
ATOM	2680	CA	LYS	A	333	28.486	−39.387	−15.401	1.00	43.57	C
ATOM	2681	CB	LYS	A	333	27.646	−40.178	−14.386	1.00	43.79	C
ATOM	2682	CG	LYS	A	333	26.178	−35.750	−14.374	1.00	41.90	C
ATOM	2683	CD	LYS	A	333	25.402	−40.375	−13.225	1.00	43.60	C
ATOM	2684	CE	LYS	A	333	25.782	−35.785	−11.882	1.00	47.23	C
ATOM	2685	NZ	LYS	A	333	24.718	−35.917	−10.844	1.00	41.88	N
ATOM	2686	C	LYS	A	333	28.747	−37.965	−14.899	1.00	42.51	C
ATOM	2687	O	LYS	A	333	28.038	−37.011	−15.337	1.00	44.47	O
ATOM	2688	N	TYR	A	334	29.706	−37.819	−13.997	1.00	41.94	N
ATOM	2689	CA	TYR	A	334	29.934	−36.523	−13.385	1.00	45.11	C
ATOM	2690	CB	TYR	A	334	30.600	−38.693	−12.029	1.00	46.53	C
ATOM	2691	CG	TYR	A	334	29.774	−37.558	−11.112	1.00	45.40	C
ATOM	2692	CD1	TYR	A	334	28.545	−37.094	−10.600	1.00	47.73	C
ATOM	2693	CE1	TYR	A	334	27.754	−37.892	−9.789	1.00	43.14	C
ATOM	2694	CZ	TYR	A	334	28.188	−35.170	−9.475	1.00	45.37	C
ATOM	2695	CH	TYR	A	334	27.421	−39.960	−8.656	1.00	41.01	O
ATOM	2696	CE2	TYR	A	334	29.403	−39.654	−9.970	1.00	44.10	C
ATOM	2697	CD2	TYR	A	334	30.175	−38.857	−10.802	1.00	41.61	C
ATOM	2698	C	TYR	A	334	30.694	−35.559	−14.300	1.00	49.55	C
ATOM	2699	O	TYR	A	334	30.359	−34.364	−14.350	1.00	47.33	O
ATOM	2700	N	SER	A	335	31.077	−30.086	−15.042	1.00	50.49	N
ATOM	2701	CA	SER	A	335	32.416	−35.315	−16.059	1.00	52.01	C
ATOM	2702	CB	SER	A	335	33.409	−36.190	−16.806	1.00	54.14	C
ATOM	2703	CG	SER	A	335	34.564	−36.368	−16.024	1.00	70.83	O
ATOM	2704	C	SER	A	335	31.491	−34.710	−17.072	1.00	48.15	C
ATOM	2705	O	SER	A	335	31.671	−33.569	−17.485	1.00	49.72	O
ATOM	2706	N	GLN	A	336	30.522	−35.508	−17.494	1.00	46.33	N
ATOM	2707	CA	GLN	A	336	29.431	−35.034	−18.328	1.00	45.96	C
ATOM	2708	CB	GLN	A	336	28.564	−36.714	−18.789	1.00	49.90	C
ATOM	2709	CG	GLN	A	336	29.235	−37.140	−19.813	1.00	47.78	C
ATOM	2710	CD	GLN	A	336	29.396	−36.488	−21.175	1.00	46.58	C
ATOM	2711	0E1	GLN	A	336	30.509	−36.227	−21.606	1.00	51.35	O
ATOM	2712	NE2	GLN	A	336	28.287	−36.201	−21.842	1.00	45.67	N
ATOM	2713	C	GLN	A	336	28.565	−33.945	−17.683	1.00	41.98	C
ATOM	2714	O	GLN	A	336	28.127	−33.034	−18.375	1.00	41.84	O
ATOM	2715	N	TYR	A	337	28.291	−34.038	−16.386	1.00	41.45	N
ATOM	2716	CA	TYR	A	337	22.485	−32.993	−15.714	1.00	42.09	C
ATOM	2717	CB	TYR	A	337	26.966	−33.446	−14.332	1.00	38.91	C
AIOM	2718	CG	TYR	A	337	25.559	−34.069	−14.786	1.00	41.93	C
ATOM	2719	CD1	TYR	A	337	24.435	−33.283	−14.047	1.00	41.24	C
ATOM	2720	CE1	TYR	A	337	23.169	−33.838	−13.986	1.00	41.40	C
ATOM	2721	CZ	TYR	A	337	23.008	−35.210	−14.146	1.00	42.05	C
ATOM	2722	OH	TYR	A	337	21.734	−35.763	−14.077	1.00	40.90	O
ATOM	2723	CE2	TYR	A	337	24.111	−36.018	−14.362	1.00	38.55	C
ATOM	2724	CD2	TYR	A	337	25.368	−35.449	−14.433	1.00	40.20	C
ATOM	2725	C	TYR	A	337	28.320	−31.696	−15.579	1.00	43.07	C
ATOM	2726	O	TYR	A	337	27.807	−30.581	−15.757	1.00	40.25	O
ATOM	2727	N	GLN	A	338	29.604	−31.860	−15.273	1.00	41.47	N
ATOM	2728	CA	GLN	A	338	30.523	−30.737	−15.197	1.00	44.04	C
ATOM	2729	CB	GLN	A	338	31.951	−31.225	−14.905	1.00	44.81	C
ATOM	2730	CG	GLN	A	338	32.887	−30.120	−14.433	1.00	45.01	C
ATOM	2731	CD	GLN	A	338	34.301	−30.624	−14.218	1.00	48.93	C
ATOM	2732	OE1	GLN	A	338	34.521	−31.625	−13.530	1.00	49.47	O
ATOM	2733	NE2	GLN	A	338	35.271	−29.932	−14.809	1.00	46.24	N
ATOM	2734	C	GLN	A	338	30.460	−29.962	−16.513	1.00	42.90	C
ATOM	2735	O	GLN	A	338	30.117	−28.770	−16.521	1.00	41.11	O
ATOM	2736	N	GLN	A	339	30.711	−30.664	−17.622	1.00	41.43	N
ATOM	2737	CA	GLN	A	339	30.640	−30.063	−18.942	1.00	41.76	C
ATOM	2738	CB	GLN	A	339	31.052	−31.062	−20.018	1.00	43.91	C
ATOM	2739	CG	GLN	A	339	31.270	−30.454	−21.411	1.00	49.59	C
ATOM	2740	CD	GLN	A	339	32.544	−29.598	−21.527	1.00	52.90	C
ATOM	2741	OE1	GLN	A	339	33.475	−29.702	−20.713	1.00	52.89	O
ATOM	2742	NE2	GLN	A	339	32.589	−28.756	−22.556	1.00	50.52	N
ATOM	2743	C	GLN	A	339	29.270	−29.428	−19.240	1.00	44.48	C
ATOM	2744	O	GLN	A	339	29.185	−28.432	−19.941	1.00	46.88	O
ATOM	2745	N	ALA	A	340	28.196	−29.980	−18.698	1.00	45.29	N
ATOM	2746	CA	ALA	A	340	26.880	−29.393	−18.954	1.00	47.01	C
ATOM	2747	CB	ALA	A	340	25.775	−30.360	−18.565	1.00	46.98	C
ATOM	2748	C	ALA	A	340	26.714	−28.080	−18.207	1.00	48.31	C
ATOM	2749	O	ALA	A	340	26.131	−27.123	−18.733	1.00	46.93	O
ATOM	2750	N	ILE	A	341	27.215	−28.053	−16.969	1.00	47.63	N
ATOM	2751	CA	ILE	A	341	27.120	−26.869	−16.133	1.00	48.37	C
ATOM	2752	CB	ILE	A	341	27.426	−27.189	−14.652	1.00	45.47	C
ATOM	2753	CG1	ILE	A	341	26.485	−28.290	−14.146	1.00	44.41	C
ATOM	2754	CD1	ILE	A	341	27.011	−29.057	−12.951	1.00	39.22	C
ATOM	2755	CG2	ILE	A	341	27.284	−25.939	−13.779	1.00	41.17	C
ATOM	2756	C	ILE	A	341	28.061	−25.798	−16.699	1.00	50.17	C
ATOM	2757	O	ILE	A	341	27.690	−24.632	−16.800	1.00	46.59	O
ATOM	2758	N	TYR	A	342	29.258	−26.231	−17.089	1.00	55.36	N
ATOM	2759	CA	TYR	A	342	30.244	−25.393	−17.771	1.00	60.36	C
ATOM	2760	CB	TYR	A	342	31.425	−26.249	−18.247	1.00	62.78	C
ATOM	2761	CG	TYR	A	342	32.432	−25.490	−19.065	1.00	70.59	C
ATOM	2762	CD1	TYR	A	342	33.507	−24.838	−18.457	1.00	74.11	O
ATOM	2763	CE1	TYR	A	342	34.435	−24.135	−19.209	1.00	76.55	C
ATOM	2764	CZ	TYR	A	342	34.287	−24.074	−20.589	1.00	78.71	C
ATOM	2765	OH	TYR	A	342	35.191	−23.384	−21.356	1.00	75.51	O
ATOM	2766	CE2	TYR	A	342	33.227	−24.712	−21.211	1.00	78.53	C
ATOM	2767	CD2	TYR	A	342	32.313	−25.418	−20.450	1.00	73.57	C
ATOM	2768	C	TYR	A	342	29.644	−24.582	−18.930	1.00	60.24	C
ATOM	2769	O	TYR	A	342	29.641	−23.153	−18.868	1.00	60.39	O
ATOM	2770	N	LYS	A	343	29.138	−25.266	−19.962	1.00	55.89	N
ATOM	2771	CA	LYS	A	343	78.510	−24.509	−21.117	1.00	56.02	C
ATOM	2772	CB	LYS	A	343	27.979	−25.516	−22.146	1.00	54.77	C
ATOM	2773	CG	LYS	A	343	29.027	−26.266	−23.044	1.00	57.30	C
ATOM	2774	CD	LYS	A	343	28.378	−26.371	−24.285	1.00	58.55	C
ATOM	2775	CE	LYS	A	343	29.415	−27.156	−25.282	1.00	60.03	C
ATOM	2776	NZ	LYS	A	343	28.817	−27.181	−26.631	1.00	61.80	N
ATOM	2777	C	LYS	A	343	27.368	−23.391	−20.705	1.00	56.45	C
ATOM	2778	O	LYS	A	343	27.285	−22.552	−21.172	1.00	62.04	O
ATOM	2779	N	CYS	A	344	26.494	−24.171	−19.828	1.00	51.66	N
ATOM	2780	CA	CYS	A	344	25.313	−23.188	−19.455	1.00	50.44	C
ATOM	2781	CB	CYS	A	344	24.388	−24.180	−18.535	1.00	47.82	C
ATOM	2782	SG	CYS	A	344	22.938	−23.333	−18.010	1.00	50.30	S
ATOM	2783	C	CYS	A	344	25.674	−22.050	−18.810	1.00	49.96	C
ATOM	2784	O	CYS	A	344	25.011	−21.039	−19.044	1.00	47.82	O
ATOM	2785	N	LEU	A	345	26.717	−22.041	−17.990	1.00	50.83	N
ATOM	2786	CA	LEU	A	345	27.143	−20.108	−17.352	1.00	54.27	C
ATOM	2787	CB	LEU	A	345	28.287	−21.471	−16.367	1.00	52.24	C
ATOM	2788	CG	LEU	A	345	27.927	−21.119	−15.082	1.00	49.46	C
ATOM	2789	CD1	LEU	A	345	79.174	−22.359	−14.320	1.00	48.33	C
ATOM	2790	CD2	LEU	A	345	26.959	−21.045	−14.196	1.00	45.62	C
ATOM	2791	C	LEU	A	345	27.568	−19.797	−18.420	1.00	59.52	C
ATOM	2792	O	LEU	A	345	27.103	−18.655	−18.428	1.00	63.52	O
ATOM	2793	N	LEU	A	346	28.417	−20.344	−19.343	1.00	58.16	N
ATOM	2794	CA	LEU	A	346	28.935	−19.378	−20.395	1.00	45.94	C
ATOM	2795	CB	LEU	A	346	29.940	−20.121	−21.286	1.00	47.50	C
ATOM	2796	CG	LEU	A	346	31.197	−20.496	−20.476	1.00	48.37	C
ATOM	2797	CD1	LEU	A	346	32.357	−21.036	−21.306	1.00	50.59	C
ATOM	2798	CD2	LEU	A	346	31.672	−19.327	−19.633	1.00	45.61	C
ATOM	2799	C	LEU	A	346	27.813	−18.724	−21.188	1.00	40.81	C
ATOM	2800	O	LEU	A	346	27.904	−17.549	−21.548	1.00	71.44	O
ATOM	2801	N	ASP	A	347	26.732	−19.467	−21.396	1.00	61.84	N
ATOM	2802	CA	ASP	A	347	25.618	−18.996	−22.211	1.00	63.45	C
ATOM	2803	CB	ASP	A	347	24.806	−20.183	−22.754	1.00	65.12	C
ATOM	2804	CG	ASP	A	347	25.641	−21.131	−23.612	1.00	69.34	C
ATOM	2805	CD1	ASP	A	347	26.893	−21.046	−23.602	1.00	66.50	O
ATOM	2806	CD2	ASP	A	347	25.034	−21.973	−24.301	1.00	71.68	O
ATOM	2807	C	ASP	A	347	24.708	−18.029	−21.468	1.00	60.07	C
ATOM	2808	O	ASP	A	347	23.821	−17.419	−22.066	1.00	62.46	O
ATOM	2809	N	ARG	A	348	24.919	−17.892	−20.166	1.00	58.81	N
ATOM	2810	CA	ARG	A	348	24.005	−17.099	−19.343	1.00	59.73	C
ATOM	2811	CB	ARG	A	348	23.341	−17.970	−18.267	1.00	58.16	C
ATOM	2812	CG	ARG	A	348	22.218	−18.850	−18.812	1.00	53.68	C
ATOM	2813	CD	ARG	A	348	21.633	−19.748	−17.737	1.00	58.68	C
ATOM	2814	NE	ARG	A	348	21.051	−18.987	−16.641	1.00	55.16	N
ATOM	2815	CZ	ARG	A	348	19.878	−18.464	−16.659	1.00	54.85	C
ATOM	2816	NH1	ARG	A	348	19.033	−18.625	−17.711	1.00	51.43	N
ATOM	2817	NH2	ARG	A	348	19.396	−17.788	−15.612	1.00	50.91	N
ATOM	2818	C	ARG	A	348	24.657	−15.86B	−18.725	1.00	59.56	C
ATOM	2819	O	ARG	A	348	23.951	−14.930	−18.311	1.00	55.26	O
ATOM	2820	N	VAL	A	349	25.993	−15.888	−18.664	1.00	59.01	N
ATOM	2821	CA	VAL	A	349	26.791	−14.757	−18.186	1.00	60.97	C
ATOM	2822	CB	VAL	A	349	27.215	−14.882	−16.701	1.00	62.45	C
ATOM	2823	CG1	VAL	A	349	25.995	−14.883	−15.793	1.00	64.54	C
ATOM	2824	CG2	VAL	A	349	28.038	−16.126	−16.465	1.00	60.52	C
ATOM	2825	C	VAL	A	349	27.996	−14.461	−19.098	1.00	64.49	C
ATOM	2826	O	VAL	A	349	28.957	−15.221	−19.128	1.00	50.00	O
ATOM	2827	N	PRO	A	350	27.900	−13.333	−19.839	1.00	67.85	N
ATOM	2828	CA	PRO	A	350	28.869	−12.885	−20.832	1.00	68.02	C
ATOM	2829	CB	PRO	A	350	28.176	−11.6S5	−21.491	1.00	68.46	C
ATOM	2830	CG	PRO	A	350	26.772	−11.671	−20.980	1.00	70.69	C
ATOM	2831	CD	PRO	A	350	26.834	−12.337	−19.646	1.00	68.39	C
ATOM	2832	C	PRO	A	350	30.137	−12.421	−20.157	1.00	66.94	C
VTOM	2833	O	PRO	A	350	30.080	−11.942	−19.024	1.00	66.29	O
ATOM	2834	N	GLU	A	351	31.258	−12.563	−20.861	1.00	69.62	N
ATOM	2835	CA	GLU	A	351	32.592	−12.173	−20.372	1.00	77.11	C
ATOM	2836	CB	GLU	A	351	33.595	−12.148	−21.531	1.00	81.39	C
ATOM	2837	CZ	GLU	A	351	35.048	−12.030	−21.102	1.00	86.98	C
ATOM	2838	CD	GLU	A	351	35.559	−13.273	−20.402	1.00	95.11	C
ATOM	2839	OE1	GLU	A	351	35.104	−13.566	−19.274	1.00	97.90	O
ATOM	2840	0E2	GLU	A	351	36.432	−13.952	−20.978	1.00	98.19	O
ATOM	2841	C	GLU	A	351	32.655	−10.850	−19.600	1.00	74.61	C
ATOM	2842	O	GLU	A	351	33.243	−10.786	−18.525	1.00	71.61	O
ATOM	2843	N	GLU	A	352	32.039	−9.8O8	−20.148	1.00	76.90	N
ATOM	2844	CA	GLU	A	352	31.993	−8.503	−19.494	1.00	77.94	C
ATOM	2845	CB	GLU	A	352	31.441	−7.434	−20.455	1.00	82.61	C
ATOM	2846	CG	GLU	A	352	29.956	−7.5S5	−20.809	1.00	88.82	C
ATOM	2847	CD	GLU	A	352	29.663	−8.421	−22.039	1.00	91.45	C
ATOM	2848	OE1	GLU	A	352	30.592	−9.043	−22.616	1.00	84.79	O
ATOM	2849	0E2	GLU	A	352	28.476	−8.475	−22.438	1.00	91.14	O
ATOM	2850	C	GLU	A	352	31.223	−8.503	−18.157	1.00	77.34	C
ATOM	2851	O	GLU	A	352	31.262	−7.518	−17.412	1.00	77.65	O
ATOM	2852	N	GLU	A	353	30.537	−9.607	−17.850	1.00	73.50	N
ATOM	2853	CA	GLU	A	353	29.761	−9.708	−16.605	1.00	67.47	C
ATOM	2854	CB	GLU	A	353	28.306	−10.066	−16.893	1.00	65.38	C
ATOM	2855	CG	GLU	A	353	27.630	−9.100	−17.846	1.00	66.23	C
ATOM	2856	CD	GLU	A	353	26.146	−8.940	−17.580	1.00	68.37	C
ATOM	2857	OE1	GLU	A	353	25.743	−8.850	−16.396	1.00	64.82	O
ATOM	2858	OE2	GLU	A	353	25.382	−8.887	−18.566	1.00	72.34	O
ATOM	2859	C	GLU	A	353	30.368	−10.679	−15.597	1.00	66.60	C
ATOM	2860	O	GLU	A	353	79.886	−10.306	−14.471	1.00	61.56	O
ATOM	2861	N	LYS	A	354	31.461	−11.321	−15.996	1.00	66.95	N
ATOM	2862	CA	LYS	A	354	32.023	−12.432	−13.256	1.00	67.64	C
ATOM	2863	CB	LYS	A	354	33.325	−12.907	−15.903	1.00	67.18	C
ATOM	2864	CG	LYS	A	354	34.523	−11.993	−15.717	1.00	70.74	C
ATOM	2865	CD	LYS	A	354	35.774	−12.697	−16.197	1.00	71.61	C
ATOM	2866	CE	LYS	A	354	36.992	−12.212	−15.435	1.00	76.32	C
ATOM	7867	NZ	LYS	A	354	38.055	−13.251	−15.398	1.00	71.37	N
ATOM	2868	C	LYS	A	354	32.188	−12.208	−13.748	1.00	78.13	C
ATOM	2869	O	LYS	A	354	31.940	−13.122	−12.951	1.00	88.73	O
ATOM	2870	N	ASP	A	355	32.584	−10.997	−13.362	1.00	80.91	N
ATOM	2871	CA	ASP	A	355	32.837	−10.671	−11.957	1.00	79.07	C
ATOM	2872	CB	ASP	A	355	34.018	−9.705	−11.837	1.00	82.85	C
ATOM	2873	CG	ASP	A	355	35.351	−10.375	−12.107	1.00	88.25	C
ATOM	2874	OD1	ASP	A	355	36.148	−9.816	−12.890	1.00	88.57	O
ATOM	2875	OD2	ASP	A	355	35.604	−11.460	−11.542	1.00	90.80	O
ATOM	2876	C	ASP	A	355	31.617	−10.376	−11.266	1.00	77.97	C
ATOM	2877	O	ASP	A	355	31.548	−10.351	−10.036	1.00	76.64	O
ATOM	2878	N	THR	A	356	30.658	−9.500	−12.057	1.00	77.86	N
ATOM	2879	CA	THR	A	356	29.479	−8.116	−11.518	1.00	80.32	C
ATOM	2880	CB	THR	A	356	29.144	−7.542	−12.334	1.00	77.53	C
ATOM	2881	OG1	THR	A	356	28.134	−6.396	−11.650	1.00	84.35	O
ATOM	2882	CG2	THR	A	356	28.643	−7.976	−13.737	1.00	78.64	C
ATOM	2883	C	THR	A	356	28.242	−9.827	−11.386	1.00	81.10	C
ATOM	2884	O	THR	A	356	27.335	−9.562	−10.587	1.00	74.92	O
ATOM	2885	N	ASN	A	357	28.215	−10.598	−12.174	1.00	79.48	N
ATOM	2886	CA	ASN	A	357	27.079	−11.307	−12.182	1.00	75.53	C
ATOM	2887	CB	ASN	A	357	26.551	−12.3319	−13.601	1.00	75.50	C
ATOM	2888	CG	ASN	A	357	25.169	−12.522	−13.616	1.00	74.77	r
ATOM	2889	OD1	ASN	A	357	24.899	−13.592	−12.916	1.00	77.39	O
ATOM	2890	ND2	ASN	A	357	24.285	−12.055	−14.416	1.00	72.58	N
ATOM	2891	C	ASN	A	357	27.395	−13.138	−11.509	1.00	72.97	C
ATOM	2892	O	ASN	A	357	28.207	−13.943	−11.997	1.00	73.74	O
ATOM	2893	N	VAL	A	558	26.746	−13.135	−10.368	1.00	64.87	N
ATOM	2894	CA	VAL	A	358	26.860	−14.553	−9.597	1.00	66.61	C
ATOM	2895	CB	VAL	A	358	27.111	−14.337	−8.093	1.00	69.88	C
ATOM	2896	CG1	VAL	A	358	26.006	−13.155	−7.510	1.00	67.68	C
ATOM	2897	CG2	VAL	A	358	27.305	−15.112	−7.280	1.00	69.62	C
ATOM	2898	C	VAL	A	358	25.604	−15.402	−9.860	1.00	61.23	C
ATOM	2899	O	VAL	A	358	24.476	−14.999	−9.530	1.00	52.25	O
ATOM	290O	N	GLN	A	359	25.790	−16.145	−10.517	1.00	59.34	N
ATOM	2901	CA	GLN	A	359	24.634	−17.406	−10.847	1.00	64.48	C
ATOM	2902	CB	GLN	A	359	24.955	−18.357	−12.015	1.00	63.75	C
ATOM	2903	CG	GLN	A	359	24.916	−17.733	−13.412	1.00	65.06	C
ATOM	2904	CD	GLN	A	359	23.542	−17.199	−13.827	1.00	62.54	C
ATOM	2905	OE1	GLN	A	359	23.185	−16.465	−13.521	1.00	60.33	O
ATOM	2906	NE2	GLN	A	359	22.786	−18.1106	−14.558	1.00	61.09	N
ATOM	2907	C	GLN	A	359	24.188	−18.211	−9.624	1.00	58.47	C
ATOM	2908	O	GLN	A	359	25.036	−18.760	−8.911	1.00	55.73	O
ATOM	2909	N	VAL	A	360	22.880	−18.261	−9.361	1.00	54.20	N
ATOM	2910	CA	VAL	A	360	22.369	−19.754	−8.306	1.00	53.98	C
ATOM	2911	CB	VAL	A	360	21.187	−18.159	−7.481	1.00	63.85	C
ATOM	2912	CG1	VAL	A	360	20.184	−17.121	−8.359	1.00	69.52	C
ATOM	2913	CG2	VAL	A	360	20.482	−19.630	−6.652	1.00	61.43	C
ATOM	2914	C	VAL	A	360	22.073	−20.559	−8.848	1.00	51.34	C
ATOM	2915	O	VAL	A	360	21.154	−20.760	−9.664	1.00	43.96	O
ATOM	2916	N	LEU	A	361	22.893	−21.506	−8.376	1.00	46.62	N
ATOM	2917	CA	LEU	A	361	22.817	−22.824	−8.698	1.00	45.84	C
ATOM	2918	CB	LEU	A	361	24.203	−23.416	−9.058	1.00	52.50	C
ATOM	2919	CG	LEU	A	361	24.378	−23.626	−10.548	1.00	56.07	C
ATOM	2920	CD1	LEU	A	361	25.827	−23.871	−10.902	1.00	49.31	C
ATOM	2921	C02	LEU	A	361	23.530	−24.832	−10.913	1.00	60.65	C
ATOM	2922	C	LEU	A	361	22.243	−23.831	−7.587	1.00	46.73	C
ATOM	2923	O	LEU	A	361	22.715	−23.815	−6.449	1.00	44.44	O
ATOM	2924	N	MET	A	362	21.229	−24.629	−7.925	1.00	42.99	N
ATOM	2925	CA	MET	A	362	20.649	−25.556	−6.965	1.00	41.48	C
ATOM	2926	CB	MET	A	362	19.193	−25.210	−6.740	1.00	42.26	C
ATOM	2927	CG	MET	A	362	19.039	−23.879	−6.033	1.00	47.89	C
ATOM	2928	SD	MET	A	362	17.317	−23.435	−5.893	1.00	50.39	S
ATOM	2929	CE	MET	A	362	17.429	−21.837	−5.095	1.00	52.97	C
ATOM	2930	C	MET	A	362	20.808	−27.017	−7.374	1.00	42.00	C
ATOM	2931	O	MET	A	362	20.360	−27.434	−8.437	1.00	18.58	O
ATOM	2932	N	VAL	A	363	21.491	−27.791	−6.539	1.00	43.19	N
ATOM	2933	CA	VAL	A	363	21.554	−29.232	−6.751	1.00	41.41	C
ATOM	2934	CB	VAL	A	363	22.871	−29.804	−6.272	1.00	39.51	C
ATOM	2935	CG1	VAL	A	363	22.915	−31.291	−6.561	1.00	39.63	C
ATOM	2936	CG2	VAL	A	363	24.018	−29.080	−6.966	1.00	40.01	C
ATOM	2937	C	VAL	A	363	20.399	−29.901	−6.011	1.00	39.93	C
ATOM	2938	C	VAL	A	363	20.271	−29.770	−4.793	1.00	39.20	O
ATOM	2939	N	LEU	A	364	19.568	−30.626	−6.744	1.00	40.01	N
ATOM	2940	CA	LEU	A	364	18.311	−31.139	−6.166	1.00	39.68	C
ATOM	2941	CB	LEU	A	364	17.109	−30.727	−7.017	1.00	35.33	C
ATOM	2942	CG	LEU	A	364	16.898	−29.209	−7.097	1.00	35.81	C
ATOM	2943	CD1	LEU	A	364	15.513	−28.831	−7.639	1.00	34.47	C
ATOM	2944	CD2	LEU	A	364	17.084	−28.618	−5.714	1.00	33.75	C
ATOM	2945	C	LEU	A	364	18.415	−32.639	−5.987	1.00	38.64	C
ATOM	2946	O	LEU	A	364	18.444	−33.374	−6.963	1.00	45.74	O
ATOM	2947	N	GLY	A	365	18.512	−33.085	−4.736	1.00	36.04	N
ATOM	2948	CA	GLY	A	365	18.899	−34.463	−4.444	1.00	36.48	C
ATOM	2949	C	GLY	A	365	20.391	−34.634	−4.632	1.00	38.38	C
4TOM	2950	O	GLY	A	365	20.842	−35.322	−5.560	1.00	42.76	O
ATOM	2951	N	ALA	A	366	21.146	−34.008	−3.733	1.00	38.75	N
ATOM	2352	CA	ALA	A	366	22.590	−33.572	−5.823	1.00	36.89	C
ATOM	2953	CB	ALA	A	366	23.027	−32.609	−3.094	1.00	36.10	C
ATOM	2954	C	ALA	A	366	23.372	−35.050	−3.273	1.00	39.85	C
ATOM	2955	O	ALA	A	366	24.631	−35.042	−3.345	1.00	36.59	O
ATOM	2956	N	GLY	A	367	22.669	−36.029	−2.687	1.00	35.93	N
ATOM	2957	CA	GLY	A	367	23.357	−37.229	−2.187	1.00	37.34	C
ATOM	2958	C	GLY	A	367	24.539	−36.831	−1.316	1.00	40.07	C
ATOM	2959	O	GLY	A	367	24.395	−35.969	−0.446	1.00	38.79	O
ATOM	2960	N	ARG	A	368	25.714	−37.412	−1.558	1.00	40.53	N
ATOM	2961	CA	ARG	A	368	26.907	−37.011	−0.778	1.00	44.28	C
ATOM	2962	CS	ARG	A	368	27.821	−38.216	−0.534	1.00	40.12	C
ATOM	2963	CB	ARG	A	368	27.225	−39.290	0.356	1.00	41.42	C
ATOM	2964	CG	ARG	A	368	27.753	−40.628	−0.106	1.00	39.32	C
ATOM	2965	NE	ARG	A	368	28.614	−41.251	0.873	1.00	40.28	N
ATOM	2966	CZ	ARG	A	368	29.710	−41.937	0.583	1.00	40.01	C
ATOM	2967	NH1	ARG	A	368	30.110	−42.068	−0.670	1.00	37.53	N
ATOM	2968	NH2	ARG	A	368	30.413	−42.476	1.568	1.00	43.39	N
ATOM	2969	C	ARG	A	368	27.740	−35.834	−1.351	1.00	47.19	C
ATOM	2970	O	ARG	A	368	28.847	−35.566	−0.869	1.00	52.32	O
ATOM	2971	N	GLY	A	369	27.233	−35.171	−2.389	1.00	46.64	N
ATOM	2972	CA	GLY	A	369	27.870	−33.972	−2.944	1.00	52.56	C
ATOM	2973	C	GLY	A	369	28.620	−33.969	−4.289	1.00	53.49	C
ATOM	2974	O	GLY	A	369	29.086	−32.904	−4.720	1.00	54.42	O
ATOM	2975	N	PRO	A	370	28.742	−35.130	−4.975	1.00	52.29	N
ATOM	2976	CA	PRO	A	370	29.592	−35.077	−6.171	1.00	50.98	C
ATOM	2977	CB	PRO	A	370	29.520	−36.511	−6.716	1.00	47.24	C
ATOM	2978	CG	PRO	A	370	28.710	−37.017	−6.228	1.00	48.09	C
ATOM	2979	CD	PRO	A	370	28.086	−36.443	−4.849	1.00	50.30	C
ATOM	2980	C	PRO	A	370	29.101	−34.053	−7.204	1.00	46.71	C
ATOM	2981	O	PRO	A	370	29.912	−33.459	−7.894	1.00	50.64	O
ATOM	2982	N	LEU	A	371	27.795	−33.844	−7.288	1.00	45.77	N
ATOM	2983	CA	LEU	A	371	27.218	−32.852	−8.700	1.00	48.65	C
ATOM	2984	CB	LEU	A	371	23.712	−33.085	−8.389	1.00	45.65	C
ATOM	2985	CG	LEU	A	371	25.137	−33.629	−9.712	1.00	47.53	C
ATOM	2986	CD1	LEU	A	371	25.865	−34.818	−10.295	1.00	45.35	C
ATOM	2987	CD2	LEU	A	371	23.653	−33.954	−9.569	1.00	46.55	C
ATOM	2988	C	LEU	A	371	27.469	−31.420	−7.720	1.00	48.85	C
ATOM	2989	O	LEU	A	371	27.481	−30.482	−8.523	1.00	50.26	O
ATOM	2990	N	VAL	A	371	27.654	−31.255	−6.413	1.00	47.02	N
ATOM	2991	CA	VAL	A	372	28.029	−29.958	−5.846	1.00	48.45	C
ATOM	2992	CB	VAL	A	372	27.786	−29.901	−4.309	1.00	50.78	C
ATOM	2993	CG1	va1	A	372	28.255	−28.582	−3.727	1.00	48.77	C
ATOM	2994	CG2	VAL	A	372	26.314	−30.110	−3.975	1.00	47.83	C
ATOM	2995	C	VAL	A	372	29.509	−29.705	−6.208	1.00	49.29	C
ATOM	2996	O	VAL	A	372	29.857	−28.642	−6.705	1.00	47.66	O
ATOM	2997	N	ASN	A	373	30.367	−30.399	−6.013	1.00	44.75	N
ATOM	2998	CA	ASN	A	373	31.724	−30.568	−6.481	1.00	46.36	C
ATOM	2999	CB	ASN	A	373	32.551	−31.767	−6.077	1.00	46.43	C
ATOM	3000	CG	ASN	A	373	32.833	−31.772	−4.607	1.00	49.38	C
ATOM	3001	OD1	ASN	A	373	33.215	−30.739	−4.045	1.00	46.12	O
ATOM	3002	ND2	ASN	A	373	32.611	−32.921	−3.953	1.00	52.96	u
ATOM	3O03	C	ASN	A	373	31.819	−30.342	−7.971	1.00	48.49	C
ATOM	3004	O	ASN	A	373	32.671	−29.584	−8.424	1.00	53.13	O
ATOM	3005	N	ALA	A	374	30.953	−30.889	−8.740	1.00	46.73	N
ATOM	3006	CA	ALA	A	374	31.046	−30.847	−10.178	1.00	45.82	C
ATOM	3007	CB	ALA	A	374	30.306	−31.358	−10.894	1.00	42.63	C
ATOM	3008	C	ALA	A	574	30.525	−29.174	−10.577	1.00	47.44	C
ATOM	3009	O	ALA	A	374	30.901	−28.338	−11.620	1.00	48.40	O
ATOM	3010	N	SER	A	375	29.685	−28.587	−9.734	1.00	45.28	N
ATOM	3011	CA	SER	A	375	29.735	−27.530	−10.000	1.00	47.83	C
ATOM	3012	CB	SER	A	375	28.013	−27.173	−9.168	1.00	46.07	C
ATOM	3013	OG	SER	A	375	26.871	−27.326	−9.672	1.00	42.49	O
ATOM	3014	C	SER	A	375	30.364	−26.558	−9.729	1.00	49.76	C
ATOM	3015	O	SER	A	375	30.626	−25.556	−10.524	1.00	53.56	O
ATOM	3016	N	LEU	A	376	31.047	−26.770	−8.613	1.00	52.37	N
ATOM	3017	CA	LEU	A	376	32.169	−25.337	−8.223	1.00	47.71	C
ATOM	3018	CB	LEU	A	376	32.713	−26.147	−6.851	1.00	46.18	C
ATOM	3019	CG	LEU	A	376	31.867	−26.164	−5.587	1.00	47.03	C
ATOM	3020	CD1	LEU	A	376	32.574	−26.112	−4.401	1.00	45.21	C
ATOM	3021	CD2	LEU	A	376	31.518	−26.709	−5.284	1.00	45.50	C
ATOM	3022	C	LEU	A	376	33.273	−26.023	−9.270	1.00	48.15	C
ATOM	3023	O	LEU	A	376	33.906	−26.012	−9.578	1.00	46.85	O
ATOM	3024	N	ARG	A	377	33.500	−27.307	−9.833	1.00	45.34	N
ATOM	3025	CA	ARG	A	377	34.578	−27.130	−10.825	1.00	47.91	C
ATOM	3026	CB	ARG	A	377	34.984	−28.782	−11.067	1.00	46.45	C
ATOM	3027	CG	ARG	A	377	35.826	−29.114	−9.986	1.00	43.90	C
ATOM	3028	CD	ARG	A	377	36.297	−30.787	−10.441	1.00	50.38	C
ATOM	3029	NE	ARG	A	377	35.199	−31.395	−10.999	1.00	57.33	N
ATOM	3030	CZ	ARG	A	377	34.466	−32.485	−10.317	1.00	56.85	C
ATOM	3031	NH1	ARG	A	377	34.691	−32.710	−9.029	1.00	56.37	N
ATOM	3032	NH2	ARG	A	377	33.498	−33.161	−10.929	1.00	57.16	N
ATOM	3033	C	ARG	A	377	34.182	−26.678	−12.149	1.00	49.08	C
ATOM	3034	O	ARG	A	377	35.016	−26.131	−12.863	1.00	47.92	O
ATOM	3035	N	ALA	A	378	32.898	−26.738	−12.462	1.00	49.60	N
ATOM	3036	CA	ALA	A	378	32.391	−26.105	−13.661	1.00	52.32	C
ATOM	3037	CB	ALA	A	378	30.952	−26.323	−13.925	1.00	49.77	C
ATOM	3038	C	ALA	A	378	32.502	−24.389	−13.607	1.00	51.82	C
ATOM	3039	O	ALA	A	378	32.737	−23.953	−14.625	1.00	50.12	O
ATOM	3040	N	ALA	A	379	32.318	−24.408	−12.429	1.00	56.66	N
ATOM	3041	CA	ALA	A	379	32.354	−22.352	−12.310	1.00	61.55	C
ATOM	3042	CB	ALA	A	379	31.634	−22.087	−11.052	1.00	57.48	C
ATOM	3043	C	ALA	A	379	33.795	−22.004	−12.382	1.00	67.64	C
ATOM	3044	O	ALA	A	379	34.037	−20.966	−13.020	1.00	66.93	O
ATOM	3045	N	LYS	A	380	34.749	−22.704	−11.764	1.00	64.60	N
ATOM	3046	CA	LYS	A	380	36.149	−22.292	−11.889	1.00	73.60	C
ATOM	3047	CB	LYS	A	380	37.034	−22.772	−10.719	1.00	75.52	C
ATOM	3048	CG	LYS	A	380	37.151	−24.275	−10.526	1.00	89.09	C
ATOM	3049	CD	LYS	A	380	38.257	−24.913	−11.366	1.00	99.15	C
ATOM	3050	CE	LYS	A	380	38.268	−26.432	−11.193	1.00	101.19	C
ATOM	3051	NZ	LYS	A	380	39.172	−27.144	−12.138	1.00	97.76	N
ATOM	3052	C	LYS	A	380	36.742	−22.652	−13.256	1.00	72.59	C
ATOM	3053	O	LYS	A	380	37.842	−22.223	−13.584	1.00	77.11	O
ATOM	3054	N	GLN	A	381	36.008	−23.424	−14.051	1.00	67.96	N
ATOM	3055	CA	GLN	A	381	36.449	−23.758	−15.403	1.00	61.97	C
ATOM	3056	CB	GLN	A	381	36.014	−25.173	−15.786	1.00	65.43	C
ATOM	3057	CG	GLN	A	381	36.833	−25.837	−16.886	1.00	62.96	C
ATOM	3058	CD	GLN	A	381	36.087	−26.981	−17.566	1.00	67.14	C
ATOM	3059	CE1	GLN	A	381	34.994	−27.369	−17.145	1.00	70.92	O
ATOM	3060	NE2	GLN	A	381	36.675	−27.523	−18.626	1.00	64.82	N
ATOM	3061	C	GLN	A	381	35.841	−22.744	−16.350	1.00	55.73	C
ATOM	3062	O	GLN	A	381	36.419	−22.399	−17.369	1.00	50.66	O
ATOM	3063	N	ALA	A	382	34.667	−22.248	−15.991	1.00	55.81	N
ATOM	3064	CA	ALA	A	382	34.009	−21.215	−16.781	1.00	55.34	C
ATOM	3065	CB	ALA	A	382	32.497	−21.267	−16.558	1.00	48.62	C
ATOM	3066	C	ALA	A	382	34.549	−19.845	−16.407	1.00	57.59	C
ATOM	3067	O	ALA	A	382	34.186	−18.840	−17.030	1.00	59.98	O
ATOM	3068	N	ASP	A	383	35.414	−19.821	−13.387	1.00	64.97	N
ATOM	3069	CA	ASP	A	383	35.692	−18.617	−14.602	1.00	67.61	C
ATOM	3070	CB	ASP	A	383	36.854	−17.794	−15.193	1.00	75.49	C
ATOM	3071	CG	ASP	A	383	37.391	−16.726	−14.219	1.00	84.76	C
ATOM	3072	OD1	ASP	A	383	36.594	−15.912	−13.689	1.00	86.90	O
ATOM	3073	OD2	ASP	A	383	38.625	−16.693	−13.993	1.00	84.17	O
ATOM	3074	C	ASP	A	383	34.404	−17.790	−14.481	1.00	63.83	C
ATOM	3075	O	ASP	A	383	34.286	−16.706	−15.060	1.00	62.62	O
ATOM	3076	N	ARG	A	384	33.422	−18.342	−13.774	1.00	57.04	N
ATOM	3077	CA	ARG	A	384	32.225	−17.579	−13.408	1.00	58.13	C
ATOM	3078	CD	ARG	A	384	11.042	−17.084	−14.335	1.00	57.25	C
ATOM	3079	CG	ARG	A	384	31.248	−17.559	−15.810	1.00	59.32	C
ATOM	3080	CD	ARG	A	384	31.364	−16.063	−16.058	1.00	58.15	C
ATOM	3081	NE	ARG	A	384	31.235	−15.701	−17.472	1.00	59.70	N
ATOM	3082	CZ	ARG	A	384	32.191	−15.838	−18.397	1.00	61.30	C
ATOM	3083	NH1	ARG	A	384	33.381	−16.371	−18.111	1.00	55.31	N
ATOM	3084	NH2	ARG	A	384	31.939	−15.460	−19.636	1.00	61.65	N
ATOM	3085	C	ARG	A	384	31.856	−17.831	−11.945	1.00	58.88	C
ATOM	3086	O	ARG	A	384	32.328	−18.793	−11.323	1.00	59.93	O
ATOM	3087	N	ARG	A	385	31.018	−16.964	−11.396	1.00	61.65	N
ATOM	3088	CA	ARG	A	385	30.725	−17023	−9.978	1.00	65.50	C
ATOM	3089	CB	ARG	A	385	30.930	−15.640	−9.333	1.00	72.61	C
ATOM	3090	CG	ARG	A	385	32.397	−15.255	−9.171	1.00	74.63	C
ATOM	3091	CD	ARG	A	385	32.604	−14.290	−8.009	1.00	77.58	C
ATOM	3092	NE	ARG	A	385	31.811	−13.049	−8.170	1.00	76.00	N
ATOM	3093	CZ	ARG	A	385	30.992	−12.546	−7.274	1.00	74.78	C
ATOM	3094	NH1	ARG	A	385	30.363	−11.404	−7.535	1.00	72.34	N
ATOM	3095	NH2	ARG	A	385	30.775	−13.163	−6.118	1.00	74.37	N
ATOM	3096	C	ARG	A	385	29.333	−17.582	−9.688	1.00	65.26	C
ATOM	3097	O	ARG	A	385	28.346	−17.218	−10.345	1.00	65.36	O
ATOM	3098	N	ILE	A	386	29.270	−18.478	−8.699	1.00	62.06	N
ATOM	3099	CA	ILE	A	386	28.018	−19.161	−8.344	1.00	56.06	C
ATOM	3100	CB	ILE	A	386	27.960	−20.579	−8.943	1.00	53.19	C
ATOM	3101	CG1	ILE	A	386	29.224	−21.367	−8.563	1.00	55.06	C
ATOM	3102	CD1	ILE	A	386	29.005	−22.850	−8.340	1.00	55.71	C
ATOM	3103	CG2	ILE	A	386	27.779	−20.493	−10.451	1.00	50.14	C
ATOM	3104	C	ILE	A	386	27.726	−19.266	−6.844	1.00	53.96	C
ATOM	3105	O	ILE	A	386	28.625	−19.467	−6.025	1.00	55.13	O
ATOM	3106	N	LYS	A	387	26.453	−19.116	−6.500	1.00	50.32	N
ATOM	3107	CA	LYS	A	387	25.970	−19.496	−5.183	1.00	50.43	C
ATOM	3108	CB	LYS	A	387	24.949	−18.482	−4.667	1.00	54.20	C
ATOM	3109	CG	LYS	A	387	24.691	−18.526	−3.166	1.00	54.30	C
ATOM	3110	CD	LYS	A	387	23.517	−17.617	−2.838	1.00	58.21	C
ATOM	3111	CE	LYS	A	387	23.543	−17.188	−1.384	1.00	65.05	C
ATOM	3112	NZ	LYS	A	387	22.577	−16.073	−1.174	1.00	69.55	N
ATOM	3113	C	LYS	A	387	25.319	−20.868	−5.328	1.00	49.22	C
ATOM	3114	O	LYS	A	387	24.603	−21.106	−6.298	1.00	50.67	O
ATOM	3115	N	LEU	A	388	25.551	−21.752	−4.358	1.00	47.05	N
ATOM	3116	CA	LEU	A	388	25.048	−23.112	−4.419	1.00	44.72	C
ATOM	3117	CB	LEU	A	388	26.212	−24.093	−4.336	1.00	44.93	C
ATOM	3118	CG	LEU	A	388	26.860	−24.436	−5.664	1.00	45.42	C
ATOM	3119	CD1	LEU	A	388	28.193	−25.112	−5.410	1.00	42.22	C
ATOM	3120	CD2	LEU	A	388	25.937	−25.311	−6.513	1.00	45.01	C
ATOM	3121	C	LEU	A	388	24.085	−23.446	−3.306	1.00	45.41	C
ATOM	3122	O	LEU	A	388	24.340	−23.123	−2.139	1.00	44.87	O
ATOM	3123	N	TYR	A	389	23.005	−24.140	−3.656	1.00	45.06	N
ATOM	3124	CA	TYR	A	389	22.162	−24.306	−2.649	1.00	42.18	C
ATOM	3125	CB	TYR	A	389	20.741	−24.319	−2.703	1.00	44.53	C
ATOM	3126	CG	TYR	A	389	20.538	−22.399	−2.279	1.00	51.50	C
ATOM	3127	CD1	TYR	A	389	20.912	−21.848	−3.114	1.00	53.39	C
ATOM	3128	CE1	TYR	A	389	20.694	−20.533	−2.748	1.00	55.05	C
ATOM	3129	CZ	TYR	A	389	20.094	−20.253	−1.535	1.00	56.87	C
ATOM	3130	OH	TYR	A	389	19.896	−18.943	−1.203	1.00	55.79	O
ATOM	3131	CE2	TYR	A	389	19.697	−21.275	−0.680	1.00	55.15	C
ATOM	3132	CD2	TYR	A	389	19.917	−22.593	−1.061	1.00	55.03	C
ATOM	3133	C	TYR	A	389	22.177	−26.306	−2.875	1.00	42.75	C
ATOM	3134	O	TYR	A	389	21.986	−26.772	−4.010	1.00	42.70	O
ATOM	3135	N	ALA	A	390	22.398	−27.063	−1.800	1.00	39.75	N
ATOM	3136	CA	ALA	A	390	22.426	−28.520	−1.886	1.00	39.40	C
ATOM	3137	CB	ALA	A	390	23.761	−29.971	−1.407	1.00	33.92	C
ATOM	3138	C	ALA	A	390	21.262	−29.141	−1.117	1.00	39.36	C
ATOM	3139	O	ALA	A	390	21.353	−29.400	0.083	1.00	42.11	O
ATOM	3140	N	VAL	A	391	20.168	−20.359	−1.823	1.00	39.41	N
ATOM	3141	CA	VAL	A	391	18.956	−29.336	−1.235	1.00	39.55	C
ATOM	3142	CB	VAL	A	391	17.735	−29.416	−1.979	1.00	38.64	C
ATOM	3143	CG1	VAL	A	391	16.468	−29.915	−1.313	1.00	41.82	C
ATOM	3144	CG2	VAL	A	391	17.788	−27.903	−2.008	1.00	40.28	C
ATOM	3145	C	VAL	A	391	18.968	−31.461	−1.306	1.00	39.67	C
ATOM	3146	O	VAL	A	391	19.143	−32.032	−2.383	1.00	43.68	O
ATOM	3147	N	GLU	A	392	18.785	−32.108	−0.158	1.00	38.84	N
ATOM	3148	CA	GLU	A	392	18.816	−33.560	−0.043	1.00	38.28	C
ATOM	3149	CB	GLU	A	392	20.228	−34.022	0.336	1.00	35.45	C
ATOM	3150	CG	GLU	A	392	20.430	−35.525	0.486	1.00	36.23	C
ATOM	3151	CD	GLU	A	392	19.734	−36.377	−0.579	1.00	37.59	C
ATOM	3152	OE1	GLU	A	392	20.027	−36.269	−1.780	1.00	37.57	O
ATOM	3153	OE2	GLU	A	392	10.891	−37.196	−0.199	1.00	39.23	O
ATOM	3154	C	GLU	A	392	17.819	−33.973	1.014	1.00	39.21	C
ATOM	3155	O	GLU	A	392	17.753	−33.362	2.081	1.00	41.57	O
ATOM	3156	N	LYS	A	393	17.025	−35.001	0.734	1.00	42.94	N
ATOM	3157	CA	LYS	A	393	15.984	−35.399	1.698	1.00	39.87	C
ATOM	3158	CB	LYS	A	393	14.652	−35.205	1.010	1.00	38.49	C
ATOM	3159	CG	LYS	A	393	14.698	−36.808	−0.015	1.00	39.69	C
ATOM	3160	CD	LYS	A	393	14.410	−38.180	0.537	1.00	39.10	C
ATOM	3161	CE	LYS	A	393	14.700	−39.282	−0.461	1.00	40.74	C
ATOM	3162	NZ	LYS	A	393	14.620	−40.61	0.169	1.00	43.22	N
ATOM	3163	C	LYS	A	393	16.454	−38.545	2.571	1.00	38.12	C
ATOM	3164	O	LYS	A	393	15.941	−36.740	3.656	1.00	41.19	O
ATOM	3165	N	ASN	A	394	17.453	−37.285	2.111	1.00	37.63	N
ATOM	3166	CA	ASN	A	394	17.993	−38.388	2.898	1.00	35.27	C
ATOM	3167	CB	ASN	A	394	18.782	−39.142	2.007	1.00	30.43	C
ATOM	3168	CG	ASN	A	394	19.413	−40.501	2.760	1.00	29.91	C
ATOM	3169	OD1	ASN	A	394	19.344	−40.608	3.991	1.00	33.20	O
ATOM	3170	ND2	ASN	A	394	20.057	−41.176	2.013	1.00	29.16	N
ATOM	3171	C	ASN	A	394	18.846	−37.782	3.998	1.00	38.78	C
ATOM	3172	C	ASN	A	394	19.986	−37.402	3.755	1.00	43.89	O
ATOM	3173	N	PRO	A	395	18.291	−37.688	5.223	1.00	41.67	N
ATOM	3174	CA	PRO	A	395	19.004	−37.044	6.328	1.00	39.08	C
ATOM	3175	CB	PRO	A	395	18.054	−37.209	7.509	1.00	38.69	C
ATOM	3176	CG	PRO	A	395	17.210	−38.384	7.143	1.00	40.21	C
ATOM	3177	CD	PRO	A	395	17.023	−38.297	5.669	1.00	38.20	C
ATOM	3178	C	PRO	A	395	20.349	−37.696	6.644	1.00	39.19	C
ATOM	3179	C	PRO	A	395	21.215	−37.049	7.208	1.00	40.77	O
ATOM	3180	N	ASN	A	396	20.524	−38.958	6.290	1.00	41.20	N
ATOM	3181	CA	ASN	A	396	21.804	−39.632	6.525	1.00	42.75	C
ATOM	3182	CB	ASN	A	396	21.647	−41.156	6.407	1.00	41.43	C
ATOM	3183	CG	ASN	A	396	20.470	−41.695	7.223	1.00	40.46	C
ATOM	3184	CG1	ASN	A	396	20.576	−41.919	8.425	1.00	40.75	O
ATOM	3185	ND2	ASN	A	396	19.338	−41.873	6.572	1.00	38.63	N
ATOM	3186	C	ASN	A	396	22.881	−39.111	5.562	1.00	47.00	C
ATOM	3187	O	ASN	A	396	24.042	−39.011	5.917	1.00	49.01	O
ATOM	3188	N	ALA	A	397	22.488	−38.781	4.337	1.00	49.24	N
ATOM	3189	CA	ALA	A	397	23.419	−38.204	3.380	1.00	47.16	C
ATOM	3190	CB	ALA	A	397	22.864	−38.307	1.967	1.00	48.95	C
ATOM	3191	C	ALA	A	397	23.649	−36.745	3.763	1.00	47.94	C
ATOM	3192	O	ALA	A	397	24.786	−36.262	3.703	1.00	46.36	O
ATOM	3193	N	VAL	A	398	22.569	−36.056	4.162	1.00	41.61	N
ATOM	3194	CA	VAL	A	398	22.672	−34.723	4.736	1.00	39.22	C
ATOM	3195	CB	VAL	A	398	21.326	−34.198	5.272	1.00	39.45	C
ATOM	3196	CG1	VAL	A	398	21.536	−32.958	6.129	1.00	35.70	C
ATOM	3197	CG2	VAL	A	398	20.396	−33.842	4.112	1.00	38.84	C
ATOM	3198	C	VAL	A	398	23.730	−34.612	5.827	1.00	39.54	C
ATOM	3199	O	VAL	A	398	24.241	−33.530	6.075	1.00	41.07	O
ATOM	3200	N	VAL	A	399	24.052	−35.718	6.488	1.00	42.31	N
ATOM	3201	CA	VAL	A	399	25.198	−35.741	7.406	1.00	44.63	C
ATOM	3202	CB	VAL	A	399	25.251	−37.062	8.223	1.00	43.69	C
ATOM	3203	CG1	VAL	A	399	26.568	−37.222	8.991	1.00	40.62	C
ATOM	3204	CG2	VAL	A	399	24.057	−37.112	9.169	1.00	29.77	C
ATOM	3205	C	VAL	A	399	26.508	−35.484	6.648	1.00	45.45	C
ATOM	3206	O	VAL	A	399	27.282	−34.604	7.020	1.00	55.19	O
ATOM	3207	N	THR	A	400	26.743	−36.244	5.588	1.00	44.52	N
ATOM	3208	CA	THR	A	400	27.945	−36.122	4.764	1.00	44.99	C
ATOM	3209	C3	THR	A	400	27.884	−37.154	3.634	1.00	44.07	C
ATOM	3210	OG1	THR	A	400	27.239	−38.329	4.126	1.00	45.89	O
ATOM	3211	CG2	THR	A	400	29.269	−37.521	3.118	1.00	41.96	C
ATOM	3212	C	THR	A	400	28.068	−34.707	4.159	1.00	47.60	C
ATOM	3213	O	THR	A	400	29.122	−34.084	4.215	1.00	44.46	O
ATOM	3214	N	LEU	A	401	26.966	−34.208	3.609	1.00	47.73	N
ATOM	3215	CA	LEU	A	401	26.923	−32.900	2.991	1.00	45.49	C
ATOM	3216	CB	LEU	A	401	25.518	−32.612	2.454	1.00	42.80	C
ATOM	3217	CG	LEU	A	401	24.966	−33.377	1.251	1.00	41.82	C
ATOM	3218	CD1	LEU	A	401	23.536	−32.946	0.958	1.00	39.32	C
ATOM	3219	CD2	LEU	A	401	25.836	−33.125	0.042	1.00	40.74	C
ATOM	3220	C	LEU	A	401	27.301	−31.817	3.979	1.00	49.67	C
ATOM	3221	O	LEU	A	401	28.101	−30.941	3.646	1.00	50.64	O
ATOM	3222	N	GLU	A	402	26.711	−31.872	5.181	1.00	47.14	N
ATOM	3223	CA	GLU	A	402	26.945	−30.860	6.209	1.00	45.60	C
ATOM	3224	CB	GLU	A	402	25.898	−30.911	7.326	1.00	42.93	C
ATOM	3225	CG	GLU	A	402	24.630	−30.180	6.919	1.00	47.09	C
ATOM	3226	CD	GLU	A	402	23.510	−30.161	7.949	1.00	51.72	C
ATOM	3227	OE1	GLU	A	402	23.434	−31.038	8.845	1.00	56.58	O
ATOM	3228	OE2	GLU	A	402	22.662	−29.257	7.835	1.00	50.28	O
ATOM	3229	C	GLU	A	402	28.377	−30.903	6.746	1.00	46.64	C
ATOM	3230	O	GLU	A	402	28.937	−29.871	7.079	5.00	45.33	O
ATOM	3231	N	ASN	A	403	28.976	−32.088	6.790	1.00	48.01	N
ATOM	3232	CA	ASN	A	403	30.392	−32.185	7.108	5.00	48.76	C
ATOM	3233	CB	ASN	A	403	30.773	−33.597	7.536	1.00	48.65	C
ATOM	3234	CG	ASN	A	403	30.353	−33.916	8.962	1.00	52.88	C
ATOM	3235	OD1	ASN	A	403	31.074	−33.628	9.922	1.00	49.56	O
ATOM	3236	ND2	ASN	A	403	29.189	−34.552	9.104	1.00	55.42	N
ATOM	3237	C	ASN	A	403	31.294	−31.712	5.962	1.00	53.22	C
ATOM	3238	O	ASN	A	403	32.367	−31.188	6.215	1.00	57.01	O
ATOM	3239	N	TRP	A	404	30.869	−31.397	4.712	1.00	54.47	N
ATOM	3240	CA	TRP	A	404	31.589	−31.323	3.571	1.00	53.62	C
ATOM	3241	CB	TRP	A	404	31.038	−31.812	2.224	1.00	56.23	C
ATOM	3242	CG	TRP	A	404	31.891	−32.852	1.552	1.00	62.03	C
ATOM	3243	CD1	TRP	A	404	31.763	−34.211	1.661	1.00	66.29	C
ATOM	3244	NE1	TRP	A	404	32.721	−34.845	0.907	1.00	66.43	N
ATOM	3245	CE2	TRP	A	404	33.493	−33.907	0.283	1.00	69.91	C
ATOM	3246	CD2	TRP	A	404	32.995	−32.629	0.662	1.00	65.26	C
ATOM	3247	CE3	TRP	A	404	33.615	−31.484	0.149	1.00	64.64	C
ATOM	3248	CZ3	TRP	A	404	34.703	−31.640	−0.772	1.00	65.72	C
ATOM	3249	CH2	TRP	A	404	35.176	−32.921	−1.074	1.00	66.95	C
ATOM	3250	CZ2	TRP	A	404	34.589	−34.059	−0.584	1.00	69.19	C
ATOM	3251	C	TRP	A	404	31.547	−29.798	3.607	1.00	52.62	C
ATOM	3252	C	TRP	A	404	32.546	−29.150	3.303	1.00	53.07	O
ATOM	3253	N	GLN	A	405	30.402	−29.228	3.976	1.00	49.94	N
ATOM	3254	CA	GLN	A	405	30.233	−27.793	3.867	1.00	52.02	C
ATOM	3255	CB	GLN	A	405	28.764	−27.393	3.638	1.00	52.61	C
ATOM	3256	CG	GLN	A	405	28.021	−26.808	4.820	1.00	57.47	C
ATOM	3257	CD	GLN	A	405	28.404	−25.366	5.134	1.00	58.05	C
ATOM	3258	OE1	GLN	A	405	28.899	−25.086	6.223	1.00	57.61	O
ATOM	3259	NE2	GLN	A	405	28.168	−24.450	4.192	1.00	57.59	N
ATOM	3260	C	GLN	A	405	30.904	−27.027	5.005	1.00	55.50	C
ATOM	3261	O	GLN	A	405	31.254	−25.864	4.835	1.00	57.09	O
ATOM	3262	N	PHE	A	406	31.106	−27.581	6.143	1.00	55.52	N
ATOM	3263	CA	PHE	A	406	31.877	−27.089	7.219	1.00	56.87	C
ATOM	3264	CB	PHE	A	406	31.479	−27.580	8.580	1.00	61.88	C
ATOM	3265	CG	PHE	A	406	32.318	−27.175	9.724	1.00	64.20	C
ATOM	3266	CD1	PHE	A	406	32.017	−25.954	10.346	1.00	67.00	C
ATOM	3267	CE1	PHE	A	406	32.806	−25.483	11.385	1.00	65.94	C
ATOM	3268	CZ	PHE	A	406	33.912	−26.209	11.811	1.00	64.09	C
ATOM	3269	CE2	PHE	A	406	34.225	−27.413	11.198	1.00	66.81	C
ATOM	3270	CD2	PHE	A	406	33.432	−27.391	10.160	1.00	66.14	C
ATOM	3271	C	PHE	A	406	33.388	−27.241	7.002	1.00	58.63	C
ATOM	3272	O	PHE	A	406	34.152	−26.330	7.311	1.00	55.94	O
ATOM	3273	N	GLU	A	407	33.817	−28.401	6.515	1.00	56.81	N
ATOM	3274	CA	GLU	A	407	35.238	−28.201	6.422	1.00	55.38	C
ATOM	3275	CB	GLU	A	407	35.510	−30.211	6.454	1.00	55.07	C
ATOM	3276	CG	GLU	A	407	35.027	−30.950	7.697	1.00	57.90	C
ATOM	3277	CD	GLU	A	407	35.662	−32.329	7.877	1.00	62.36	C
ATOM	3278	OE1	GLU	A	407	36.270	−32.371	6.926	1.00	63.11	O
ATOM	3279	OE2	GLU	A	407	35.570	−32.881	8.997	1.00	66.55	O
ATOM	3280	C	GLU	A	407	35.865	−28.116	5.166	1.00	57.19	C
ATOM	3281	O	GLU	A	407	37.055	−27.857	5.142	1.00	57.33	O
ATOM	3282	N	GLU	A	408	35.066	−27.918	4.122	1.00	61.49	N
ATOM	3283	CA	GLU	A	408	35.607	−27.614	2.797	1.00	56.92	C
ATOM	3284	CB	GLU	A	408	35.601	−28.860	1.910	1.00	58.79	C
ATOM	3285	CG	GLU	A	408	36.479	−30.002	2.393	1.00	68.31	C
ATOM	3286	CD	GLU	A	408	37.963	−29.151	2.193	1.00	72.57	C
ATOM	3287	DE1	GLU	A	408	38.345	−29.099	1.196	1.00	76.60	O
ATOM	3288	OE2	GLU	A	408	38.754	−30.221	3.031	1.00	74.84	O
ATOM	3289	C	GLU	A	408	34.867	−26.497	2.082	1.00	54.93	C
ATOM	3290	O	GLU	A	408	35.429	−25.455	1.808	1.00	55.42	O
ATOM	3291	N	TRP	A	409	33.604	−26.715	1.758	1.00	55.22	N
ATOM	3292	CA	TRP	A	409	32.939	−25.107	0.838	1.00	55.23	C
ATOM	3293	CB	TRP	A	409	31.548	−26.325	0.432	1.00	54.39	C
ATOM	3294	CG	TRP	A	409	31.562	−27.651	−0.270	1.00	56.14	C
ATOM	3295	CD1	TRP	A	409	32.565	−28.265	−1.054	1.00	57.64	C
ATOM	3296	NE1	TRP	A	409	32.213	−29.411	−1.517	1.00	58.65	N
ATOM	3297	CE2	TRP	A	409	30.967	−29.725	−1.036	1.00	57.91	C
ATOM	3298	CD2	TRP	A	409	30.526	−28.638	−0.248	1.00	15.00	C
ATOM	3299	CE3	TRP	A	409	29.262	−25.707	0.356	1.00	52.36	C
ATOM	3300	CZ3	TRP	A	409	28.492	−29.847	0.167	1.00	53.35	C
ATOM	3301	CH2	TRP	A	409	28.955	−30.909	−0.619	1.00	54.19	C
ATOM	3302	CZ2	TRP	A	409	30.190	−30.868	−1.228	1.00	56.71	C
ATOM	3303	C	TRP	A	409	32.833	−24.382	1.357	1.00	55.16	C
ATOM	3304	O	TRP	A	409	32.804	−23.442	0.561	1.00	58.89	O
ATOM	3305	N	GLY	A	410	32.754	−22.223	2.678	1.00	55.20	N
ATOM	3306	CA	GLY	A	410	32.409	−22.932	3.282	1.00	52.78	C
ATOM	3307	C	GLY	A	410	31.029	−22.497	2.826	1.00	53.28	C
ATOM	3308	O	GLY	A	410	30.287	−23.296	2.238	1.00	51.86	O
ATOM	3309	N	SER	A	411	30.694	−21.228	3.068	1.00	51.42	N
ATOM	3310	CA	SER	A	411	29.325	−26.719	2.849	1.00	49.76	C
ATOM	3311	CB	SER	A	411	29.041	−19.486	3.732	1.00	51.10	C
ATOM	3312	OG	SER	A	411	29.525	−18.300	3.121	1.00	14.91	O
ATOM	3313	C	SER	A	411	28.958	−20.448	1.380	1.00	47.87	C
ATOM	3314	O	SER	A	411	27.866	−19.934	1.075	1.00	45.35	O
ATOM	3315	N	GLN	A	412	29.836	−20.803	0.451	1.00	46.57	N
ATOM	3316	CA	GLN	A	412	29.382	−20.807	−0.933	1.00	12.28	C
ATOM	3317	CB	GLN	A	412	30.521	−21.083	−1.890	1.00	10.56	C
ATOM	3318	CG	GLN	A	412	30.200	−20.594	−3.289	1.00	12.17	C
ATOM	3319	CD	GLN	A	412	31.291	−20.909	−4.286	1.00	51.94	C
ATOM	3320	CE1	GLN	A	412	32.267	−21.603	−3.975	1.00	54.92	O
ATOM	3321	NE2	GLN	A	412	31.129	−20.407	−5.500	1.00	50.86	N
ATOM	3322	C	GLN	A	412	28.211	−21.815	−1.151	1.00	55.84	C
ATOM	3323	O	GLN	A	412	27.323	−21.591	−1.991	1.00	15.85	O
ATOM	3324	N	VAL	A	413	28.214	−22.894	−0.368	1.00	53.21	N
ATOM	3325	CA	VAL	A	413	27.155	−23.902	−0.402	1.00	53.99	C
ATOM	3326	CB	VAL	A	413	27.740	−25.322	−0.538	1.00	55.88	C
ATOM	3327	CG1	VAL	A	413	26.627	−26.330	−0.813	1.00	55.68	C
ATOM	3328	CG2	VAL	A	413	28.816	−25.380	−1.624	1.00	51.25	C
ATOM	3329	C	VAL	A	413	26.260	−23.857	0.846	1.00	54.87	C
ATOM	3330	C	VAL	A	413	20.747	−23.991	1.976	1.00	53.86	O
ATOM	3331	N	THR	A	414	24.958	−23.663	0.626	1.00	53.69	N
ATOM	3332	CA	THR	A	414	23.933	−23.787	1.672	1.00	53.46	C
ATOM	3333	CB	THR	A	414	22.819	−22.734	1.491	1.00	13.17	C
ATOM	3334	CG1	THR	A	414	23.400	−21.432	1.485	1.00	60.06	O
ATOM	3335	CG2	THR	A	414	21.769	−22.808	2.607	1.00	48.39	C
ATOM	3336	C	THR	A	414	23.307	−25.194	1.602	1.00	53.27	C
ATOM	3337	C	THR	A	414	22.554	−25.506	0.665	1.00	50.61	O
ATOM	3338	N	VAL	A	415	23.607	−26.033	2.593	1.00	49.64	N
ATOM	3339	CA	VAL	A	415	23.043	−27.380	2.631	1.00	47.08	C
ATOM	3340	CB	VAL	A	415	23.905	−28.345	3.454	1.00	42.93	C
ATOM	3341	CG1	VAL	A	415	23.207	−29.682	3.586	1.00	22.27	C
ATOM	3342	CG2	VAL	A	415	25.237	−28.543	2.762	1.00	44.78	C
ATOM	3343	C	VAL	A	415	21.622	−27.331	3.168	1.00	45.72	C
ATOM	3344	O	VAL	A	415	21.396	−26.808	4.258	1.00	46.00	O
ATOM	3345	N	VAL	A	416	20.669	−27.832	2.380	1.00	26.22	N
ATOM	3346	CA	VAL	A	416	19.256	−27.872	2.803	1.00	46.17	C
ATOM	3347	CB	VAL	A	416	18.313	−27.110	1.864	1.00	44.35	C
ATOM	3348	CG1	VAL	A	416	16.869	−27.245	2.342	1.00	42.19	C
ATOM	3349	CG2	VAL	A	416	18.720	−25.647	1.790	1.00	46.55	C
ATOM	3350	C	VAL	A	416	18.761	−29.298	2.969	1.00	47.51	C
ATOM	3351	O	VAL	A	416	18.735	−30.088	2.018	1.00	45.62	O
ATOM	3352	N	SER	A	417	18.373	−29.622	4.194	1.00	48.22	N
ATOM	3353	CA	SER	A	417	17.822	−30.926	4.485	1.00	49.63	C
ATOM	3354	CB	SER	A	417	18.255	−31.387	5.870	1.00	49.40	C
ATOM	3355	OG	SER	A	417	17.817	−32.714	6.100	1.00	57.95	O
ATOM	3356	C	SER	A	417	16.306	−30.863	4.391	1.00	48.37	C
ATOM	3357	O	SER	A	417	15.648	−30.542	5.372	1.00	47.25	O
ATOM	3358	N	SER	A	418	15.770	−31.129	3.197	1.00	48.01	N
ATOM	3359	CA	SER	A	418	14.322	−31.301	3.003	1.00	49.17	C
ATOM	3360	CB	SER	A	418	13.564	−29.979	3.177	1.00	50.40	C
ATOM	3361	OG	SER	A	418	13.456	−29.301	1.948	1.00	50.16	O
ATOM	3362	C	SER	A	418	13.981	−31.898	1.633	1.00	50.25	C
ATOM	3363	O	SER	A	418	14.855	−32.109	0.787	1.00	50.42	O
ATOM	3364	N	ASP	A	419	12.696	−32.167	1.432	1.00	45.08	N
ATOM	3365	CA	ASP	A	419	12.217	−32.644	0.170	1.00	43.04	C
ATOM	3366	CB	ASP	A	419	10.852	−33.305	0.353	1.00	43.05	C
ATOM	3367	CG	ASP	A	419	10.472	−34.188	−0.824	1.00	43.63	C
ATOM	3368	OD1	ASP	A	419	10.234	−33.683	−1.946	1.00	41.65	O
ATOM	3369	OD2	ASP	A	419	10.433	−35.412	−0.625	1.00	48.25	O
ATOM	3370	C	ASP	A	419	12.106	−31.459	−0.790	1.00	46.50	C
ATOM	3371	O	ASP	A	419	11.570	−30.403	−0.424	1.00	46.50	O
ATOM	3372	N	MET	A	420	12.567	−31.635	−2.026	1.00	41.97	N
ATOM	3373	CA	MET	A	420	12.504	−30.541	−2.987	1.00	39.77	C
ATOM	3374	CB	MET	A	420	13.266	−30.866	−4.264	1.00	38.64	C
ATOM	3375	CG	MET	A	420	12.601	−31.918	−5.136	1.00	41.52	C
ATOM	3376	SD	MET	A	420	13.403	−32.183	−6.733	1.00	40.88	S
ATOM	3377	CE	MET	A	420	14.897	−33.068	−6.205	1.00	34.57	C
ATOM	3378	C	MET	A	420	11.080	−30.096	−3.314	1.00	42.24	C
ATOM	3379	O	MET	A	420	10.899	−28.973	−3.758	1.00	43.88	O
ATOM	3380	N	ARG	A	421	10.080	−30.966	−3.114	1.00	42.78	N
ATOM	3381	CA	ARG	A	421	8.660	−30.583	−3.331	1.00	44.35	C
ATOM	3382	CB	ARG	A	421	7.733	−31.799	−3.462	1.00	44.20	C
ATOM	3383	CG	ARG	A	421	7.959	−32.702	−4.668	1.00	44.75	C
ATOM	3384	CD	ARG	A	421	8.476	−34.034	−4.193	1.00	43.95	C
ATOM	3385	NE	ARG	A	421	7.448	−35.062	−4.182	1.00	46.40	N
ATOM	3386	CZ	ARG	A	471	7.401	−36.074	−3.317	1.00	47.67	C
ATOM	3387	NH1	ARG	A	421	6.441	−36.983	−3.409	1.00	54.69	N
ATOM	3388	NH2	ARG	A	421	8.298	−36.180	−2.354	1.00	42.93	N
ATOM	3389	C	ARG	A	421	8.116	−29.712	−2.208	1.00	45.04	C
ATOM	3390	O	ARG	A	421	7.049	−29.121	−2.343	1.00	47.52	O
ATOM	3391	N	GLU	A	422	8.848	−29.647	−1.103	1.00	46.17	N
ATOM	3392	CA	GLU	A	422	8.386	−29.004	0.120	1.00	53.17	C
ATOM	3393	CB	GLU	A	422	8.573	−29.953	1.313	1.00	60.87	C
ATOM	3394	CG	GLU	A	422	7.680	−31.181	1.292	1.00	69.35	C
ATOM	3395	CD	GLU	A	422	6.214	−30.815	1.161	1.00	75.53	C
ATOM	3396	OE1	GLU	A	422	5.702	−30.076	2.032	1.00	81.39	O
ATOM	3397	OE2	GLU	A	422	5.579	−31.260	0.182	1.00	76.82	O
ATOM	3398	C	GLU	A	422	9.141	−27.711	0.398	1.00	53.16	C
ATOM	3399	O	GLU	A	422	8.538	−26.696	0.745	1.00	51.39	O
ATOM	3400	N	TRP	A	423	10.466	−27.773	0.250	1.00	57.61	N
ATOM	3401	CA	TRP	A	423	11.364	−26.651	0.507	1.00	55.46	C
ATOM	3402	CB	TRP	A	423	12.721	−26.916	−0.126	1.00	55.94	C
ATOM	3403	CG	TRP	A	423	13.779	−25.942	0.269	1.00	58.11	C
ATOM	3404	CD1	TRP	A	423	14.061	−25.492	1.532	1.00	60.18	C
ATOM	3405	NE1	TRP	A	423	15.123	−24.515	1.497	1.00	61.21	N
ATOM	3406	CE2	TRP	A	423	15.540	−24.481	0.198	1.00	59.65	N
ATOM	3407	CD2	TRP	A	423	14.717	−25.310	−0.602	1.00	57.05	C
ATOM	3408	CE3	TRP	A	423	14.945	−25.361	−1.986	1.00	57.72	C
ATOM	3409	CZ3	TRP	A	423	15.967	−24.591	−2.526	1.00	58.51	C
ATOM	3410	CH2	TRP	A	423	16.759	−23.764	−1.704	1.00	62.37	C
ATOM	3411	CZ2	TRP	A	423	16.561	−23.700	−0.342	1.00	59.17	C
ATOM	3412	C	TRP	A	423	10.804	−25.117	0.035	1.00	57.17	C
ATOM	3413	O	TRP	A	423	10.414	−25.166	−1.124	1.00	55.66	O
ATOM	3414	N	VAL	A	424	10.720	−24.165	0.960	1.00	56.65	N
ATOM	3415	CA	VAL	A	424	10.345	−23.111	0.603	1.00	57.48	C
ATOM	3416	CB	VAL	A	424	9.438	−22.145	1.671	1.00	60.17	C
ATOM	3417	CGI	VAL	A	424	9.275	−20.356	1.403	1.00	58.39	C
ATOM	3418	CG2	VAL	A	424	8.063	−23.115	1.697	1.00	55.99	C
ATOM	3419	C	VAL	A	424	11.674	−22.105	0.401	1.00	55.99	C
ATOM	3420	O	VAL	A	424	12.441	−22.128	1.351	1.00	61.59	O
ATOM	3421	N	ALA	A	425	11.966	−21.965	−0.852	1.00	57.93	N
ATOM	3422	CA	ALA	A	425	13.283	−21.447	−1.222	1.00	62.21	C
ATOM	3423	CB	ALA	A	425	13.581	−21.764	−2.681	1.00	61.76	C
ATOM	3424	C	ALA	A	425	13.408	−19.941	−0.959	1.00	59.89	C
ATOM	3425	O	ALA	A	425	12.514	−19.173	−1.315	1.00	61.36	O
ATOM	3426	H	PRO	A	426	14.522	−19.510	−0.340	1.00	61.27	N
ATOM	3427	CA	PRO	A	426	14.675	−19.081	−0.013	1.00	62.93	C
ATOM	3428	CB	PRO	A	426	15.965	−19.051	0.809	1.00	59.93	C
ATOM	3429	CG	PRO	A	426	16.749	−19.221	0.310	1.00	60.09	C
ATOM	3430	CD	PRO	A	426	15.725	−20.283	0.019	1.00	61.84	C
ATOM	3431	C	PRO	A	426	14.806	−17.175	−1.254	1.00	61.45	C
ATOM	3432	O	PRO	A	426	14.643	−15.963	−1.148	1.00	60.13	O
ATOM	3433	N	GLU	A	427	15.082	−17.781	−2.410	1.00	61.35	N
ATOM	3434	CA	GLU	A	427	15.261	−17.089	−3.689	1.00	56.98	C
ATOM	3435	CB	GLU	A	427	16.653	−16.446	−3.763	1.00	55.25	C
ATOM	3436	CG	GLU	A	427	17.815	−11.375	−3.442	1.00	53.86	C
ATOM	3437	CD	GLU	A	427	19.173	−16.718	−3.683	1.00	54.86	C
ATOM	3438	OE1	GLU	A	427	19.243	−15.814	−4.539	1.00	54.54	O
ATOM	3439	OE2	GLU	A	427	20.180	−17.111	−3.038	1.00	53.19	O
ATOM	3440	C	GLU	A	427	15.078	−18.072	−4.850	1.00	57.82	C
ATOM	3441	O	GLU	A	427	15.183	−19.284	−4.663	1.00	59.39	O
ATOM	3442	N	LYS	A	428	14.807	−17.549	−6.045	1.00	59.96	N
ATOM	3443	CA	LYS	A	428	14.681	−18.371	−7.255	1.00	55.05	C
ATOM	3444	CB	LYS	A	428	13.757	−11.687	−8.267	1.00	52.16	C
ATOM	3445	CG	LYS	A	428	12.351	−17.450	−7.700	1.00	57.69	C
ATOM	3446	CD	LYS	A	428	11.283	−17.129	−8.746	1.00	53.68	C
ATOM	3447	CE	LYS	A	428	9.909	−17.414	−8.162	1.00	61.39	C
ATOM	3448	NZ	LYS	A	428	8.766	−16.755	−8.862	1.00	63.16	N
ATOM	3449	C	LYS	A	428	16.057	−18.749	−7.846	1.00	35.12	C
ATOM	3450	O	LYS	A	428	17.070	−18.108	−7.554	1.00	56.23	O
ATOM	3451	N	ALA	A	429	16.108	−15.817	−8.635	1.00	52.61	N
ATOM	3452	CA	ALA	A	429	17.392	−20.298	−9.172	1.00	50.07	C
ATOM	3453	CB	ALA	A	429	17.569	−21.789	−8.924	1.00	46.85	C
ATOM	3454	C	ALA	A	429	17.566	−20.000	−10.649	1.00	49.71	C
ATOM	3455	C	ALA	A	429	16.582	−19.920	−11.412	1.00	45.38	O
ATOM	3456	N	ASP	A	430	16.031	−19.041	−11.034	1.00	47.51	N
ATOM	3457	CA	ASP	A	430	19.218	−19.698	−12.425	1.00	49.63	C
ATOM	3458	CB	ASP	A	430	20.631	−19.111	−12.498	1.00	57.80	C
ATOM	3459	CG	ASP	A	430	20.654	−17.613	−12.288	1.00	56.51	C
ATOM	3460	CD1	ASP	A	430	20.318	−16.890	−13.259	1.00	50.79	O
ATOM	3461	CD2	ASP	A	430	21.019	−17.176	−11.167	1.00	52.14	O
ATOM	3462	C	ASP	A	430	19.222	−21.059	−13.118	1.00	50.23	C
ATOM	3463	C	ASP	A	430	18.897	−21.175	−14.309	1.00	48.68	O
ATOM	3464	N	ILE	A	431	19.630	−22.076	−12.356	1.00	48.91	N
ATOM	3465	CA	ILE	A	431	19.808	−23.431	−12.837	1.00	46.08	C
ATOM	3466	CB	ILE	A	431	21.249	−23.722	−13.327	1.00	48.90	C
ATOM	3467	CG1	ILE	A	431	21.835	−22.576	−14.191	1.00	45.38	C
ATOM	3468	CD1	ILE	A	431	23.314	−22.742	−14.500	1.00	46.74	C
ATOM	3469	CG2	ILE	A	431	21.317	−25.108	−13.989	1.00	42.93	C
ATOM	3470	C	ILE	A	431	19.607	−24.389	−11.680	1.00	48.51	C
ATOM	3471	O	ILE	A	431	20.213	−24.226	−10.606	1.00	42.81	O
ATOM	3472	N	ILE	A	432	18.766	−25.395	−11.916	1.00	45.48	N
ATOM	3473	CA	ILE	A	432	18.675	−26.533	−11.043	1.00	38.85	C
ATOM	3474	CB	ILE	A	432	17.208	−26.861	−10.737	1.00	43..70	C
ATOM	3475	CG1	ILE	A	432	16.398	−27.037	−12.024	1.00	41.81	C
ATOM	3476	CD1	ILE	A	432	14.895	−27.023	−11.822	1.00	42.49	C
ATOM	3477	CG2	ILE	A	432	16.595	−25.761	−9.871	1.00	45.05	C
ATOM	3478	C	ILE	A	432	19.420	−27.713	−11.682	1.00	39.52	C
ATOM	3479	O	ILE	A	432	19.369	−27.936	−12.894	1.00	40.89	O
ATOM	3480	N	VAL	A	433	20.142	−28.450	−10.863	1.00	36.02	N
ATOM	3481	CA	VAL	A	433	20.846	−29.624	−11.311	1.00	37.68	C
ATOM	3482	CB	VAL	A	433	22.359	−29.502	−11.043	1.00	37.51	C
ATOM	3483	CB1	VAL	A	433	23.077	−30.773	−11.428	1.00	39.74	C
ATOM	3484	CB2	VAL	A	433	22.947	−28.353	−11.828	1.00	36.75	C
ATOM	3485	c	VAL	A	433	20.282	−30.815	−10.542	1.00	37.43	C
ATOM	3486	O	VAL	A	433	20.106	−30.736	−9.324	1.00	36.34	O
ATOM	3487	N	SER	A	434	19.970	−31.901	−11.246	1.00	35.12	N
ATOM	3488	CA	SER	A	434	19.446	−33.104	−10.575	1.00	34.08	C
ATOM	3489	CB	SER	A	434	17.902	−33.099	−10.479	1.00	33.11	C
ATOM	3490	OG	SER	A	434	17.285	−33.266	−11.749	1.00	31.71	O
ATOM	3491	C	SER	A	434	19.860	−34.321	−11.302	1.00	32.40	C
ATOM	3492	O	SER	A	434	20.032	−34.287	−12.507	1.00	36.25	O
ATOM	3493	N	GLU	A	135	20.002	−35.405	−10.558	1.00	36.15	N
ATOM	3494	CA	GLU	A	435	20.192	−36.725	−11.132	1.00	33.79	C
ATOM	3495	CB	GLU	A	435	21.644	−37.160	−10.928	1.00	33.50	C
ATOM	3496	CG	GLU	A	435	22.048	−38.321	−11.821	1.00	37.87	C
ATOM	3497	CD	GLU	A	435	21.439	−39.648	−11.384	1.00	43.18	C
ATOM	3498	OE1	GLU	A	435	22.176	−40.434	−10.749	1.00	41.55	O
ATOM	3499	OE2	GLU	A	435	20.223	−39.901	−11.666	1.00	42.31	O
ATOM	3500	C	GLU	A	435	19.195	−37.707	−10.468	1.00	31.78	C
ATOM	3501	O	GLU	A	435	19.512	−38.438	−9.517	1.00	27.62	O
ATOM	3522	N	LEU	A	436	17.968	−37.706	−10.959	1.00	34.36	N
ATOM	3503	CA	LEU	A	436	16.911	−38.466	−10.289	1.00	34.93	C
ATOM	3504	CB	LEU	A	436	15.789	−37.518	−9.934	1.00	37.03	C
ATOM	3505	CG	LEU	A	436	16.283	−36.309	−9.174	1.00	35.30	C
ATOM	3506	CD1	LEU	A	436	15.148	−35.305	−9.069	1.00	30.46	C
ATOM	3507	CD2	LEU	A	436	16.820	−36.787	−7.822	1.00	33.66	C
ATOM	3508	C	LEU	A	436	16.353	−39.538	−11.189	1.00	36.85	C
ATOM	3509	O	LEU	A	436	15.137	−39.812	−11.167	1.00	35.76	O
ATOM	3510	N	LEU	A	437	17.242	−40.118	−11.991	1.00	35.38	N
ATOM	3511	CA	LEU	A	437	16.843	−40.871	−13.152	1.00	36.33	C
ATOM	3512	CB	LEU	A	437	17.636	−40.420	−14.372	1.00	39.74	C
ATOM	3513	CG	LEU	A	437	17.392	−39.026	−14.941	1.00	44.82	C
ATOM	3514	CD1	LEU	A	437	18.119	−38.924	−16.278	1.00	44.46	C
ATOM	3515	CD2	LEU	A	437	15.905	−38.729	−15.109	1.00	43.81	C
ATOM	3516	C	LEU	A	437	17.102	−42.325	−12.939	1.00	36.50	C
ATOM	3517	O	LEU	A	437	18.158	−42.696	−12.416	1.00	37.27	O
ATOM	3518	N	GLY	A	438	16.153	−43.151	−13.381	1.00	32.53	N
ATOM	3519	CA	GLY	A	438	16.294	−44.602	−13.286	1.00	28.23	C
ATOM	3520	C	GLY	A	438	16.527	−45.182	−14.653	1.00	27.06	C
ATOM	3521	O	GLY	A	438	16.533	−44.445	−15.626	1.00	25.68	O
ATOM	3522	N	SER	A	439	16.671	−46.504	−14.737	1.00	27.86	N
ATOM	3523	CA	SER	A	439	17.078	−47.135	−15.991	1.00	29.53	C
ATOM	3524	CB	SER	A	439	17.393	−48.619	−15.821	1.00	29.29	C
ATOM	3525	OG	SER	A	439	18.269	−48.858	−14.734	1.00	29.81	O
ATOM	3526	C	SER	A	439	16.054	−46.936	−17.084	1.00	28.89	C
ATOM	3527	O	SER	A	439	16.363	−47.147	−18.259	1.00	28.58	O
ATOM	3528	N	PHE	A	440	14.851	−46.508	−16.706	1.00	29.34	N
ATOM	3529	CA	PHE	A	440	13.784	−46.292	−17.674	1.00	28.69	C
ATOM	3530	CB	PHE	A	440	12.586	−47.162	−17.292	1.00	28.88	C
ATOM	3531	CG	PHE	A	440	11.620	−47.419	−18.418	1.00	27.75	C
ATOM	3532	CD1	PHE	A	440	12.071	−47.863	−19.672	1.00	28.40	C
ATOM	3533	CE1	PHE	A	440	11.175	−48.112	−20.703	1.00	28.14	C
ATOM	3534	CZ	PHE	A	440	9.795	−47.348	−20.486	1.00	25.56	C
ATOM	3535	CE2	PHE	A	440	9.344	−47.541	−19.252	1.00	25.16	C
ATOM	3536	CD2	PHE	A	440	10.248	−47.261	−18.224	1.00	27.14	C
ATOM	3537	C	PHE	A	440	13.413	−44.305	−17.670	1.00	31.14	C
ATOM	3538	O	PHE	A	440	12.252	−44.431	−17.932	1.00	30.17	O
ATOM	3539	N	ALA	A	441	14.417	−43.975	−17.357	1.00	31.21	N
ATOM	3540	CA	ALA	A	441	14.326	−42.116	−17.263	1.00	32.43	C
ATOM	3541	CB	ALA	A	441	13.783	−41.897	−18.557	1.00	34.42	C
ATOM	3542	C	ALA	A	441	13.506	−42.045	−16.080	1.00	34.90	C
ATOM	3543	O	ALA	A	441	14.050	−41.520	−15.063	1.00	37.01	O
ATOM	3544	N	ASP	A	442	12.183	−42.127	−16.221	1.00	36.69	N
ATOM	3545	CA	ASP	A	442	11.283	−41.467	−15.315	1.00	33.27	C
ATOM	3546	CB	ASP	A	442	10.129	−40.186	−16.113	1.00	35.56	C
ATOM	3347	CG	ASP	A	442	9.359	−41.347	−16.852	1.00	37.14	C
ATOM	3548	OD1	ASP	A	442	9.641	−42.189	−18.048	1.00	38.37	O
ATOM	3549	OD2	ASP	A	442	8.484	−42.164	−16.213	1.00	37.82	O
ATOM	3550	C	ASP	A	442	10.767	−42.369	−14.188	1.00	32.89	C
ATOM	3551	C	ASP	A	442	9.923	−41.952	−13.398	1.00	30.30	O
ATOM	3552	N	ASN	A	443	11.297	−43.581	−14.101	1.00	30.07	N
ATOM	3553	CA	ASN	A	443	10.808	−44.567	−13.159	1.00	29.57	C
ATOM	3554	CB	ASN	A	443	11.158	−45.989	−13.641	1.00	26.20	C
ATOM	3555	CG	ASN	A	443	12.664	−46.233	−13.704	1.00	28.08	C
ATOM	3556	CD1	ASN	A	443	13.403	−45.523	−14.410	1.00	25.29	O
ATOM	3557	ND2	ASN	A	443	13.126	−47.245	−12.963	1.00	24.02	N
ATOM	3558	C	ASN	A	443	11.260	−44.328	−11.718	1.00	32.98	C
ATOM	3559	C	ASN	A	443	10.878	−48.069	−10.800	1.00	34.91	O
ATOM	3560	N	GLU	A	444	12.065	−43.291	−11.507	1.00	35.49	N
ATOM	3561	CA	GLU	A	444	12.361	−42.847	−10.144	1.00	14.91	C
ATOM	3562	CD	GLU	A	444	13.870	−42.721	−9.875	1.00	36.96	C
ATOM	3563	CG	GLU	A	444	14.532	−44.097	−9.855	1.00	35.58	C
ATOM	3564	CD	GLU	A	444	16.003	−44.114	−9.426	1.00	39.30	C
ATOM	3565	OE1	GLU	A	444	16.590	−43.090	−8.993	1.00	42.13	O
ATOM	3566	OE2	GLU	A	444	16.584	−45.203	−9.503	1.00	39.69	O
ATOM	3567	C	GLU	A	444	11.623	−42.586	−9.798	1.00	34.95	C
ATOM	3568	O	GLU	A	444	11.833	−41.024	−8.745	1.00	36.50	O
ATOM	3569	N	LEU	A	445	10.708	−41.167	−10.659	1.00	36.11	N
ATOM	3570	CA	LEU	A	445	9.848	−40.039	−10.347	1.00	38.39	C
ATOM	3571	CB	LEU	A	445	9.192	−40.215	−8.974	1.00	36.53	C
ATOM	3572	CG	LEU	A	415	7.913	−41.060	−8.953	1.00	38.86	C
ATOM	3573	CD1	LEU	A	445	7.851	−42.125	−10.040	1.00	39.35	C
ATOM	3574	CD2	LEU	A	445	7.749	−41.682	−7.583	1.00	36.78	C
ATOM	3575	C	LEU	A	445	10.530	−38.666	−10.461	1.00	39.27	C
ATOM	3576	O	LEU	A	445	10.058	−37.672	−9.888	1.00	37.05	O
ATOM	3577	N	SER	A	446	11.606	−38.613	−11.247	1.00	39.82	N
ATOM	3578	CA	SER	A	446	12.206	−37.341	−11.634	1.00	38.00	C
ATOM	3579	CB	SER	A	446	13.297	−37.559	−12.668	1.00	40.03	C
ATOM	3580	CG	SER	A	446	14.001	−36.356	−12.922	1.00	39.42	O
ATOM	3581	C	SER	A	446	11.190	−36.289	−12.122	1.00	35.49	C
ATOM	3582	O	SER	A	446	11.515	−35.127	−11.765	1.00	38.11	O
ATOM	3583	N	PRO	A	447	10.178	−36.682	−12.917	1.00	36.32	N
ATOM	3584	CA	PRO	A	447	9.180	−35.658	−13.281	1.00	35.17	C
ATOM	3585	CB	PRO	A	447	8.176	−36.442	−14.132	1.00	33.91	C
ATOM	3586	CG	PRO	A	447	9.049	−37.453	−14.815	1.00	35.97	C
ATOM	3587	CD	PRO	A	447	10.044	−37.883	−13.771	1.00	35.20	C
ATOM	3588	C	PRO	A	447	8.469	−35.015	−12.115	1.00	36.19	C
ATOM	3589	O	PRO	A	447	8.334	−33.792	−12.088	1.00	35.70	O
ATOM	3590	N	GLU	A	448	8.012	−35.830	−11.163	1.00	41.44	N
ATOM	3591	CA	GLU	A	448	7.148	−35.341	−10.092	1.00	40.30	C
ATOM	3592	CB	GLU	A	448	6.463	−36.491	−9.339	1.00	40.88	C
ATOM	3593	CG	GLU	A	448	5.367	−37.251	−10.098	1.00	40.59	C
ATOM	3594	CD	GLU	A	448	5.870	−38.158	−11.221	1.00	41.65	C
ATOM	3595	OE1	GLU	A	448	7.087	−58.507	−11.273	1.00	41.68	O
ATOM	3596	OE2	GLU	A	448	5.032	−38.513	−12.081	1.00	38.15	O
ATOM	3597	C	GLU	A	448	8.011	−34.513	−9.158	1.00	38.67	C
ATOM	3598	O	GLU	A	448	7.589	−33.468	−8.663	1.00	35.98	O
ATOM	3599	N	CYS	A	449	9.231	−34.979	−8.935	1.00	36.18	N
ATOM	3600	CA	CYS	A	449	10.158	−34.269	−8.082	1.00	35.68	C
ATOM	3601	CB	CYS	A	449	11.454	−35.067	−7.931	1.00	37.23	C
ATOM	3602	SG	CYS	A	449	11.285	−36.536	−6.885	1.00	39.22	S
ATOM	3603	C	CYS	A	449	10.451	−32.876	−8.656	1.00	39.15	C
ATOM	3604	O	CYS	A	449	10.282	−31.864	−7.979	1.00	39.58	O
ATOM	3605	N	LEU	A	450	10.873	−32.820	−9.914	1.00	42.61	N
ATOM	3606	CA	LEU	A	450	11.250	−31.555	−10.502	1.00	42.01	C
ATOM	3607	CB	LEU	A	450	12.039	−31.769	−11.784	1.00	40.39	C
ATOM	3608	CG	LEU	A	450	13.445	−32.394	−11.668	1.00	46.06	C
ATOM	3609	CD1	LEU	A	450	14.103	−32.533	−13.045	1.00	40.62	C
ATOM	3610	CD2	LEU	A	450	14.372	−31.657	−10.693	1.00	41.29	C
ATOM	3611	C	LEU	A	450	10.043	−30.617	−10.698	1.00	44.72	C
ATOM	3612	O	LEU	A	450	10.182	−29.395	−10.561	1.00	44.85	O
ATOM	3613	N	ASP	A	451	8.873	−31.183	−10.992	1.00	43.98	N
ATOM	3614	CA	ASP	A	451	7.650	−30.392	−11.128	1.00	44.28	C
ATOM	3615	CB	ASP	A	451	6.427	−31.287	−11.392	1.00	45.24	C
ATOM	3616	CG	ASP	A	451	6.323	−31.744	−12.819	1.00	47.47	C
ATOM	3617	OD1	ASP	A	451	7.263	−31.489	−13.606	1.00	47.02	O
ATOM	3618	OD2	ASP	A	451	5.289	−32.374	−13.147	1.00	50.02	O
ATOM	3619	C	ASP	A	451	7.359	−29.514	−9.861	1.00	43.71	C
ATOM	3620	O	ASP	A	451	6.881	−28.485	−9.916	1.00	44.74	O
ATOM	3621	N	GLY	A	452	7.588	−30.254	−8.719	1.00	43.07	N
ATOM	3622	CA	GLY	A	452	7.249	−29.666	−7.432	1.00	43.54	C
ATOM	3623	C	GLY	A	452	8.332	−28.722	−6.946	1.00	43.28	C
ATOM	3624	O	GLY	A	452	8.221	−28.145	−5.885	1.00	47.72	O
ATOM	3625	N	ALA	A	453	9.376	−28.573	−7.745	1.00	43.67	N
ATOM	3626	CA	ALA	A	453	10.517	−27.732	−7.421	1.00	46.71	C
ATOM	3627	CB	ALA	A	453	11.823	−28.512	−7.591	1.00	37.90	C
ATOM	3628	C	ALA	A	453	10.522	−26.518	−8.335	1.00	47.26	C
ATOM	3629	O	ALA	A	453	10.948	−25.437	−7.936	1.00	48.26	O
ATOM	3630	N	GLN	A	454	10.039	−26.700	−9.559	1.00	49.01	N
ATOM	3631	CA	GLN	A	454	10.246	−25.699	−10.591	1.00	55.86	C
ATOM	3632	CB	GLN	A	454	9.746	−26.186	−11.956	1.00	56.88	C
ATOM	3633	CG	GLN	A	454	8.240	−26.196	−12.147	1.00	53.74	C
ATOM	3634	CD	GLN	A	454	7.824	−26.564	−13.536	1.00	53.69	C
ATOM	3635	OE1	GLN	A	454	8.653	−27.068	−14.356	1.00	50.68	O
ATOM	3636	NE2	GLN	A	454	6.520	−26.531	−13.798	1.00	58.30	N
ATOM	3637	C	GLN	A	454	9.730	−24.293	−10.244	1.00	56.30	C
ATOM	3638	O	GLN	A	454	10.262	−23.308	−10.758	1.00	56.85	O
ATOM	3639	N	HIS	A	455	8.728	−24.201	−9.366	1.00	56.87	N
ATOM	3640	CA	HIS	A	455	8.212	−22.398	−8.911	1.00	58.44	C
ATOM	3641	CB	HIS	A	455	7.139	−23.081	−7.843	1.00	55.12	C
ATOM	3642	CG	HIS	A	455	7.673	−23.511	−6.551	1.00	56.09	C
ATOM	3643	ND1	HIS	A	455	8.046	−22.793	−5.507	1.00	56.78	N
ATOM	3644	CE1	HIS	A	455	8.481	−23.531	−4.504	1.00	53.88	C
ATOM	3645	NE2	HIS	A	455	8.411	−24.800	−4.866	1.00	52.42	N
ATOM	3646	CD2	HIS	A	455	7.921	−24.377	−6.142	1.00	55.29	C
ATOM	3647	C	HIS	A	455	9.315	−21.977	−8.364	1.00	59.08	C
ATOM	3648	O	HIS	A	455	9.113	−20.768	−8.258	1.00	62.19	O
ATOM	3649	N	PHE	A	456	10.464	−22.543	−7.995	1.00	56.78	N
ATOM	3650	CA	PHE	A	456	11.603	−21.723	−7.583	1.00	50.65	C
ATOM	3651	CB	PHE	A	456	12.082	−22.060	−6.162	1.00	50.01	C
ATOM	3652	CG	PHE	A	456	12.617	−23.453	−5.983	1.00	49.62	C
ATOM	3653	CD1	PHE	A	456	13.873	−23.312	−6.472	1.00	50.07	C
ATOM	3654	CE1	PHE	A	456	14.377	−25.092	−6.278	1.00	48.90	C
ATOM	3655	CZ	PHE	A	456	13.639	−26.024	−5.555	1.00	49.75	C
ATOM	3656	CE2	PHE	A	456	12.396	−25.574	−5.045	1.00	50.47	C
ATOM	3657	CD2	PHE	A	456	11.895	−24.394	−5.252	1.00	50.17	C
ATOM	3658	C	PHE	A	456	12.748	−21.563	−8.600	1.00	51.88	C
ATOM	3659	O	PHE	A	456	13.886	−21.314	−8.266	1.00	52.26	O
ATOM	3600	N	LEU	A	457	12.429	−21.991	−9.846	1.00	52.58	N
ATOM	3661	CA	LEU	A	457	13.314	−21.742	−10.967	1.00	53.51	C
ATOM	3662	CB	LEU	A	457	13.223	−22.894	−11.972	1.00	51.36	C
ATOM	3663	CG	LEU	A	457	14.201	−22.951	−13.161	1.00	51.83	C
ATOM	3664	CD1	LEU	A	457	15.598	−23.426	−12.768	1.00	47.88	C
ATOM	3665	CD2	LEU	A	457	13.643	−23.316	−14.284	1.00	49.11	C
ATOM	3666	C	LEU	A	457	12.896	−20.421	−11.610	1.00	58.86	C
ATOM	3667	O	LEU	A	457	11.698	−20.179	−11.845	1.00	61.53	O
ATOM	3668	N	LYS	A	458	13.870	−19.354	−11.886	1.00	61.04	N
ATOM	3669	CA	LYS	A	458	13.566	−18.254	−12.522	1.00	65.44	C
ATOM	3670	CB	LYS	A	458	14.817	−17.272	−12.629	1.00	65.97	C
ATOM	3671	CG	LYS	A	458	15.367	−16.328	−11.275	1.00	69.42	C
ATOM	3672	CD	LYS	A	458	16.342	−15.767	−11.364	1.00	71.98	C
ATOM	3673	CE	LYS	A	458	17.662	−16.193	−11.981	1.00	69.50	C
ATOM	3674	NZ	LYS	A	458	18.649	−15.077	−11.934	1.00	76.12	N
ATOM	3675	C	LYS	A	458	12.921	−18.454	−13.888	1.00	64.10	C
ATOM	3676	O	LYS	A	458	13.089	−19.513	−14.495	1.00	62.83	O
ATOM	3677	N	ASP	A	459	12.185	−17.445	−14.360	1.00	66.20	N
ATOM	3678	CA	ASP	A	459	11.379	−17.566	−15.594	1.00	62.13	C
ATOM	3679	CB	ASP	A	459	10.603	−16.273	−15.883	1.00	64.79	C
ATOM	3680	CG	ASP	A	459	9.410	−16.082	−14.945	1.00	68.11	C
ATOM	3681	CD1	ASP	A	459	9.096	−17.005	−14.169	1.00	71.41	O
ATOM	3682	CD2	ASP	A	459	8.775	−15.009	−14.976	1.00	68.15	O
ATOM	3683	C	ASP	A	459	12.173	−18.025	−16.818	1.00	57.16	C
ATOM	3684	O	ASP	A	459	11.636	−18.715	−17.683	1.00	54.66	O
ATOM	3685	N	ASP	A	460	13.444	−17.630	−16.868	1.00	52.18	N
ATOM	3686	CA	ASP	A	460	14.372	−18.005	−17.926	1.00	51.95	C
ATOM	3687	CB	ASP	A	460	15.235	−16.785	−18.322	1.00	57.42	C
ATOM	3688	CG	ASP	A	460	16.060	−16.228	−17.139	1.00	59.48	C
ATOM	3689	CD1	ASP	A	460	15.735	−15.123	−16.666	1.00	67.30	O
ATOM	3690	CD2	ASP	A	460	17.005	−16.896	−16.652	1.00	57.79	O
ATOM	3691	C	ASP	A	460	15.304	−19.118	−17.443	1.00	49.25	C
ATOM	3692	O	ASP	A	460	16.377	−19.325	−18.020	1.00	45.85	O
ATOM	3693	N	GLY	A	461	14.915	−19.802	−16.369	1.00	49.05	N
ATOM	3694	CA	GLY	A	161	15.789	−20.783	−15.707	1.00	52.89	C
ATOM	3695	C	GLY	A	461	16.067	−22.022	−16.539	1.00	48.92	C
ATOM	3696	O	GLY	A	461	15.282	−22.383	−17.417	1.00	49.28	O
ATOM	3697	N	VAL	A	462	17.206	−22.643	−16.274	1.00	46.61	N
ATOM	3698	CA	VAL	A	462	17.604	−23.871	−16.941	1.00	45.73	C
ATOM	3699	CB	VAL	A	462	19.042	−23.794	−17.490	1.00	46.56	C
ATOM	3700	CG1	VAL	A	462	19.473	−25.127	−18.077	1.00	44.99	C
ATOM	3701	CG2	VAL	A	462	19.155	−22.718	−18.549	1.00	48.32	C
ATOM	3702	C	VAL	A	462	17.526	−25.037	−15.954	1.00	45.90	C
ATOM	3703	O	VAL	A	462	17.967	−24.928	−14.801	1.00	43.87	O
ATOM	3704	N	SER	A	463	16.950	−26.148	−16.413	1.00	42.18	N
ATOM	3705	CA	SER	A	463	17.045	−27.401	−15.692	1.00	38.29	C
ATOM	3706	CB	SER	A	463	15.686	−28.111	−15.669	1.00	41.25	C
ATOM	3707	OG	SER	A	463	15.823	−29.436	−15.193	1.00	42.50	O
ATOM	3708	C	SER	A	463	18.085	−28.275	−16.371	1.00	35.76	C
ATOM	3709	O	SER	A	463	18.059	−28.458	−17.588	1.00	34.40	O
ATOM	3710	N	ILE	A	464	19.007	−28.792	−15.583	1.00	33.38	N
ATOM	3711	CA	ILE	A	464	19.873	−29.840	−16.038	1.00	34.53	C
ATOM	3712	CB	ILE	A	464	21.351	−29.420	−15.922	1.00	33.64	C
ATOM	3713	CG1	ILE	A	464	21.659	−28.311	−16.935	1.00	35.95	C
ATOM	3714	CD1	ILE	A	464	22.934	−27.532	−16.642	1.00	36.35	C
ATOM	3715	CG2	ILE	A	464	22.258	−30.618	−16.147	1.00	32.17	C
ATOM	3716	C	ILE	A	464	19.573	−31.108	−15.213	1.00	36.22	C
ATOM	3717	O	ILE	A	464	19.893	−31.181	−14.005	1.00	37.04	O
ATOM	3718	N	PRO	A	465	18.985	−32.134	−15.857	1.00	37.82	N
ATOM	3719	CA	PRO	A	465	18.728	−32.342	−17.292	1.00	36.47	C
ATOM	3720	CB	PRO	A	465	18.326	−33.821	−17.381	1.00	39.49	C
ATOM	3721	CG	PRO	A	465	18.280	−34.345	−15.980	1.00	38.33	C
ATOM	3722	CD	PRO	A	465	18.382	−33.197	−15.032	1.00	38.98	C
ATOM	3723	C	PRO	A	465	17.589	−31.521	−17.816	1.00	34.71	C
ATOM	3724	O	PRO	A	465	16.688	−31.143	−17.036	1.00	31.60	O
ATOM	3725	N	GLY	A	466	17.626	−31.246	−19.121	1.00	32.54	N
ATOM	3726	CA	GLY	A	466	16.502	−30.565	−19.784	1.00	35.93	C
ATOM	3727	C	GLY	A	466	15.452	−31.537	−20.287	1.00	37.70	C
ATOM	3728	O	GLY	A	466	14.269	−31.208	−20.402	1.00	40.35	O
ATOM	3729	N	GLU	A	467	15.874	−32.768	−20.545	1.00	39.25	N
ATOM	3730	CA	GLU	A	467	15.023	−33.707	−21.237	1.00	42.33	C
ATOM	3731	CB	GLU	A	467	15.091	−33.414	−22.728	1.00	47.99	C
ATOM	3732	CG	GLU	A	467	13.804	−33.658	−23.475	1.00	52.47	C
ATOM	3733	CD	GLU	A	467	14.025	−33.685	−24.975	1.00	56.29	C
ATOM	3734	OE1	GLU	A	467	14.899	−34.439	−25.447	1.00	55.85	O
ATOM	3735	OE2	GLU	A	467	13.319	−32.946	−25.682	1.00	61.10	O
ATOM	3736	C	GLU	A	467	15.472	−35.125	−21.004	1.00	40.60	C
ATOM	3737	O	GLU	A	467	16.671	−35.390	−20.859	1.00	42.00	O
ATOM	3738	N	TYR	A	468	14.508	−36.037	−20.964	1.00	36.50	N
ATOM	3739	CA	TYR	A	468	14.819	−37.472	−21.004	1.00	35.84
ATOM	3740	CB	TYR	A	468	15.138	−38.356	−19.604	1.00	35.20	C
ATOM	3741	CG	TYR	A	468	14.351	−37.502	−18.433	1.00	33.67	C
ATOM	3742	CD1	TYR	A	468	13.110	−38.347	−18.068	1.00	36.91	C
ATOM	3743	CE1	TYR	A	468	12.385	−37.541	−16.999	1.00	34.65	C
ATOM	3744	CZ	TYR	A	468	32.909	−36.487	−16.256	1.00	38.00	C
ATOM	3745	OH	TYR	A	468	12.200	−35.973	−15.179	1.00	35.86	O
ATOM	3746	CE2	TYR	A	468	14.152	−35.946	−16.590	1.00	34.55	C
ATOM	3747	CD2	TYR	A	468	14.853	−36.460	−17.671	1.00	34.10	C
ATOM	3748	C	TYR	A	468	13.762	−38.292	−21.749	1.00	35.53	C
ATOM	3749	O	TYR	A	468	12.566	−37.922	−21.799	1.00	34.36	O
ATOM	3750	N	THR	A	469	14.211	−39.401	−22.332	1.00	34.97	N
ATOM	3751	CA	THR	A	469	13.345	−40.259	−23.140	1.00	34.32	C
ATOM	3752	CB	THR	A	469	13.580	−39.369	−24.638	1.00	35.21	C
ATOM	3753	OG1	THR	A	469	13.176	−38.625	−24.914	1.00	36.49	O
ATOM	3754	CG2	THR	A	469	12.807	−40.941	−25.563	1.00	33.21	C
ATOM	3755	C	THR	A	469	13.600	−41.740	−22.827	1.00	33.51	C
ATOM	3756	O	THR	A	469	14.744	−42.156	−22.775	1.00	34.44	O
ATOM	3757	N	SER	A	470	12.539	−42.527	−22.639	1.00	31.27	N
ATOM	3758	CA	SER	A	470	12.689	−43.967	−22.421	1.00	28.62	C
ATOM	3759	CB	SER	A	470	11.708	−44.491	−21.370	1.00	30.06	C
ATOM	3760	OG	SER	A	470	10.368	−44.250	−21.745	1.00	33.04	O
ATOM	3761	C	SER	A	470	12.561	−44.744	−23.721	1.00	26.98	C
ATOM	3762	O	SER	A	470	12.077	−44.228	−24.732	1.00	27.81	O
ATOM	3763	N	PHE	A	471	13.048	−45.972	−23.718	1.00	26.36	N
ATOM	3764	CA	PHE	A	471	13.015	−46.799	−24.909	1.00	27.71	C
ATOM	3765	CB	PHE	A	471	14.363	−46.323	−25.594	1.00	28.62	C
ATOM	3766	CG	PHE	A	471	14.735	−45.550	−26.261	1.00	30.95	C
ATOM	3767	CD1	PHE	A	471	15.306	−44.510	−25.528	1.00	31.54	C
ATOM	3768	CE1	PHE	A	471	15.684	−43.335	−26.143	1.00	34.67	C
ATOM	3769	CZ	PHE	A	471	15.521	−43.195	−27.513	1.00	37.25	C
ATOM	3770	CE2	PHE	A	471	14.964	−44.238	−28.262	1.00	37.40	C
ATOM	3771	CD2	PHE	A	471	14.585	−45.414	−27.634	1.00	32.17	C
ATOM	3772	C	PHE	A	471	12.705	−48.221	−24.530	1.00	27.45	C
ATOM	3773	O	PHE	A	471	13.040	−48.554	−23.433	1.00	29.36	O
ATOM	3774	N	LEU	A	472	12.110	−48.359	−25.464	1.00	26.18	N
ATOM	3775	CA	LEU	A	472	11.812	−50.361	−25.230	1.00	25.44	C
ATOM	3776	CB	LEU	A	472	10.308	−50.555	−24.973	1.00	26.32	C
ATOM	3777	CG	LEU	A	472	9.747	−50.074	−23.651	1.00	26.42	C
ATOM	3778	CD1	LEU	A	472	8.214	−50.032	−23.748	1.00	28.93	C
ATOM	3779	CD2	LEU	A	472	10.221	−51.009	−22.553	1.00	22.56	C
ATOM	3780	C	LEU	A	472	12.209	−51.122	−26.453	1.00	24.46	C
ATOM	3781	O	LEU	A	472	12.144	−50.577	−27.544	1.00	23.87	O
ATOM	3782	N	ALA	A	473	12.632	−52.366	−26.253	1.00	25.21	N
ATOM	3783	CA	ALA	A	473	12.862	−53.331	−27.323	1.00	27.08	C
ATOM	3784	CB	ALA	A	473	14.358	−53.419	−27.624	1.00	27.57	C
ATOM	3785	C	ALA	A	473	12.348	−54.690	−26.825	1.00	28.80	C
ATOM	3786	O	ALA	A	473	12.564	−55.044	−25.657	1.00	28.40	O
ATOM	3787	N	PRO	A	474	11.671	−55.465	−27.686	1.00	30.26	N
ATOM	3788	CA	PRO	A	474	11.257	−56.792	−27.208	1.00	33.51	C
ATOM	3789	CB	PRO	A	474	10.263	−57.257	−28.276	1.00	29.99	C
ATOM	3790	CG	PRO	A	474	10.688	−56.549	−29.497	1.00	29.65	C
ATOM	3791	CD	PRO	A	474	11.164	−55.194	−29.032	1.00	31.91	C
ATOM	3792	C	PRO	A	474	12.452	−57.742	−27.162	1.00	33.68	C
ATOM	3793	O	PRO	A	474	13.356	−57.597	−27.965	1.00	36.48	O
ATOM	3794	N	ILE	A	475	12.439	−58.697	−26.243	1.00	32.95	N
ATOM	3795	CA	ILE	A	475	13.514	−59.644	−26.135	1.00	35.44	C
ATOM	3796	CB	ILE	A	475	14.433	−59.368	−24.929	1.00	35.15	C
ATOM	3797	CG1	ILE	A	475	13.657	−59.463	−23.640	1.00	34.40	C
ATOM	3798	CD1	ILE	A	475	14.421	−60.197	−22.568	1.00	36.57	C
ATOM	3799	CG2	ILE	A	475	15.083	−58.010	−25.048	1.00	36.57	C
ATOM	3800	C	ILE	A	475	13.025	−61.072	−26.022	1.00	37.97	C
ATOM	3801	O	ILE	A	475	11.935	−61.348	−25.505	1.00	37.69	O
ATOM	3802	N	SER	A	476	13.852	−61.975	−26.540	1.00	38.71	N
ATOM	3803	CA	SER	A	476	13.732	−63.377	−26.212	1.00	41.02	C
ATOM	3804	CB	SER	A	476	14.034	−64.228	−27.438	1.00	42.98	C
ATOM	3805	OG	SER	A	476	13.439	−65.491	−27.270	1.00	49.06	O
ATOM	3806	C	SER	A	476	14.739	−63.719	−25.140	1.00	38.30	C
ATOM	3807	O	SER	A	476	15.896	−63.351	−25.248	1.00	40.90	O
ATOM	3808	N	SER	A	477	14.310	−64.415	−24.101	1.00	38.25	N
ATOM	3809	CA	SER	A	477	15.261	−65.066	−23.212	1.00	37.24	C
ATOM	3810	CB	SER	A	477	16.121	−64.106	−22.400	1.00	34.49	C
ATOM	3811	OG	SER	A	477	16.596	−64.777	−21.225	1.00	31.70	O
ATOM	3812	C	SER	A	477	14.517	−65.947	−22.274	1.00	37.97	C
ATOM	3813	O	SER	A	477	13.838	−65.490	−21.365	1.00	38.64	O
ATOM	3814	N	SER	A	478	14.721	−67.231	−22.457	1.00	41.24	N
ATOM	3815	CA	SER	A	478	14.101	−68.197	−21.594	1.00	41.48	C
ATOM	3816	CG	SER	A	478	14.022	−69.524	−22.330	1.00	39.86	C
ATOM	3817	OG	SER	A	478	13.681	−69.260	−23.720	1.00	37.54	O
ATOM	3818	C	SER	A	478	14.843	−68.236	−20.267	1.00	43.44	C
ATOM	3819	O	SER	A	478	14.250	−68.484	−19.218	1.00	46.81	O
ATOM	3820	N	LYS	A	479	16.132	−67.918	−20.295	1.00	49.48	C
ATOM	3821	CA	LYS	A	479	16.901	−67.829	−19.042	1.00	49.54	C
ATOM	3822	CB	LYS	A	479	18.383	−67.507	−19.333	1.00	49.96	C
ATOM	3823	CG	LYS	A	479	19.185	−66.872	−18.194	1.00	54.04	C
ATOM	3824	CD	LYS	A	479	19.444	−67.824	−17.033	1.00	58.10	C
ATOM	3825	CE	LYS	A	479	20.404	−67.239	−16.005	1.00	58.81	C
ATOM	3826	NZ	LYS	A	479	20.268	−67.926	−14.680	1.00	59.05	N
ATOM	3827	C	LYS	A	479	16.249	−66.818	−18.080	1.00	45.25	C
ATOM	3828	O	LYS	A	479	15.952	−67.148	−16.938	1.00	47.22	O
ATOM	3829	N	LEU	A	480	16.016	−65.599	−18.568	1.00	41.05	N
ATOM	3830	CA	LEU	A	480	15.438	−64.512	−17.769	1.00	37.55	C
ATOM	3831	CB	LEU	A	480	15.621	−63.176	−18.488	1.00	39.10	C
ATOM	3832	CG	LEU	A	480	17.062	−62.638	−18.446	1.00	40.63	C
ATOM	3833	CD1	LEU	A	480	17.241	−61.466	−19.392	1.00	35.94	C
ATOM	3834	CD2	LEU	A	480	17.449	−62.271	−17.011	1.00	35.26	C
ATOM	3835	C	LEU	A	480	13.967	−64.730	−17.423	1.00	37.13	C
ATOM	3836	O	LEU	A	480	13.532	−64.486	−16.277	1.00	35.35	O
ATOM	3837	N	TYR	A	481	13.204	−65.214	−18.399	1.00	36.73	N
ATOM	3838	CA	TYR	A	481	11.852	−65.667	−18.105	1.00	39.08	C
ATOM	3839	CB	TYR	A	481	11.240	−66.424	−19.291	1.00	39.31	O
ATOM	3840	CG	TYR	A	481	9.851	−66.976	−18.970	1.00	43.01	C
ATOM	3841	CD1	TYR	A	481	8.729	−66.145	−19.019	1.00	39.80	C
ATOM	3842	CE1	TYR	A	481	7.468	−66.624	−18.714	1.00	42.47	C
ATOM	3843	CZ	TYR	A	481	7.296	−67.959	−18.367	1.00	44.78	C
ATOM	3844	OH	TYR	A	481	6.020	−68.404	−18.070	1.00	47.31	O
ATOM	3845	CE2	TYR	A	481	8.394	−68.821	−18.300	1.00	44.74	C
ATOM	3846	CD2	TYR	A	481	9.663	−68.329	−18.597	1.00	41.69	C
ATOM	3847	C	TYR	A	481	11.890	−66.551	−16.870	1.00	37.00	C
ATOM	3848	O	TYR	A	481	11.096	−66.399	−15.942	1.00	39.68	O
ATOM	3849	N	ASN	A	482	12.840	−67.469	−16.850	1.00	40.44	N
ATOM	3850	CA	ASN	A	482	12.911	−68.446	−15.776	1.00	42.63	C
ATOM	3851	CB	ASN	A	482	13.772	−69.616	−16.217	1.00	49.98	C
ATOM	3852	CG	ASN	A	482	13.116	−70.941	−15.947	1.00	53.15	C
ATOM	3853	OD1	ASN	A	482	12.250	−71.055	−15.082	1.00	60.93	O
ATOM	3854	ND2	ASN	A	482	13.525	−71.956	−16.687	1.00	54.03	N
ATOM	3855	C	ASN	A	482	13.392	−67.868	−14.461	1.00	41.27	C
ATOM	3856	O	ASN	A	482	12.958	−68.279	−13.384	1.00	45.15	O
ATOM	3857	N	GLU	A	483	14.287	−66.897	−14.557	1.00	40.44	N
ATOM	3858	CA	GLU	A	483	14.707	−66.132	−13.408	1.00	40.71	C
ATOM	3859	CB	GLU	A	483	15.847	−65.192	−13.829	1.00	48.52	C
ATOM	3860	CG	GLU	A	483	17.218	−65.855	−13.906	1.00	54.49	C
ATOM	3861	CD	GLU	A	483	17.896	−65.875	−12.545	1.00	64.45	C
ATOM	3862	CE1	GLU	A	483	18.350	−64.795	−12.088	1.00	74.66	O
ATOM	3863	OE2	GLU	A	483	17.959	−66.953	−11.915	1.00	61.65	O
ATOM	3864	C	GLU	A	483	13.548	−65.334	−12.804	1.00	33.63	C
ATOM	3865	O	GLU	A	483	13.418	−65.231	−11.598	1.00	30.55	O
ATOM	3866	N	VAL	A	484	12.709	−64.736	−13.638	1.00	33.60	N
ATOM	3867	CA	VAL	A	484	11.549	−63.993	−13.109	1.00	32.59	C
ATOM	3868	CB	VAL	A	484	10.782	−63.243	−14.218	1.00	33.26	C
ATOM	3869	CG1	VAL	A	484	9.500	−62.599	−13.670	1.00	34.88	C
ATOM	3870	CG2	VAL	A	484	11.680	−62.230	−14.900	1.00	31.77	C
ATOM	3871	C	VAL	A	484	10.606	−64.959	−12.408	1.00	33.54	C
ATOM	3872	O	VAL	A	484	10.238	−64.754	−11.249	1.00	34.98	O
ATOM	3873	N	ARG	A	485	10.238	−66.022	−13.119	1.00	37.13	N
ATOM	3874	CA	ARG	A	485	9.315	−67.031	−12.609	1.00	43.14	C
ATOM	3875	CB	ARG	A	485	9.250	−68.215	−13.578	1.00	47.02	C
ATOM	3876	CG	ARG	A	485	7.851	−68.762	−13.771	1.00	51.39	C
ATOM	3877	CD	ARG	A	485	7.803	−69.363	−14.807	1.00	53.67	C
ATOM	3878	NE	ARG	A	485	8.755	−70.903	−14.442	1.00	64.44	N
ATOM	3879	CZ	ARG	A	485	8.574	−72.203	−14.636	1.00	59.60	C
ATOM	3880	NH1	ARG	A	485	7.447	−72.544	−15.197	1.00	52.57	N
ATOM	3881	NH2	ARG	A	485	9.527	−73.051	−14.247	1.00	53.85	N
ATOM	3882	C	ARG	A	485	9.776	−67.496	−11.243	1.00	44.23	C
ATOM	3883	O	ARG	A	485	8.972	−67.748	−10.339	1.00	45.60	O
ATOM	3884	N	ALA	A	486	11.090	−67.582	−11.075	1.00	44.91	N
ATOM	3885	CA	ALA	A	486	11.635	−68.205	−9.824	1.00	45.17	C
ATOM	3886	CB	ALA	A	486	13.087	−68.353	−10.006	1.00	45.86	C
ATOM	3887	C	ALA	A	486	11.492	−67.113	−8.677	1.00	43.26	C
ATOM	3888	O	ALA	A	486	11.842	−67.422	−7.550	1.00	42.42	O
ATOM	3889	N	CYS	A	487	10.961	−65.926	−8.961	1.00	44.56	N
ATOM	3890	CA	CYS	A	487	10.781	−64.890	−7.928	1.00	41.73	C
ATOM	3891	CB	CYS	A	487	10.908	−63.506	−8.539	1.00	45.62	C
ATOM	3892	SG	CYS	A	487	12.591	−62.954	−8.776	1.00	43.43	S
ATOM	3893	C	CYS	A	487	9.431	−64.907	−7.233	1.00	41.89	C
ATOM	3894	O	CYS	A	487	9.058	−63.998	−6.622	1.00	39.84	O
ATOM	3895	N	ARG	A	488	8.675	−66.000	−7.358	1.00	39.16	N
ATOM	3896	CA	ARG	A	488	7.454	−66.148	−6.575	1.00	39.60	C
ATOM	3897	CB	ARG	A	488	6.735	−67.449	−6.932	1.00	39.96	C
ATOM	3898	CG	ARG	A	488	5.383	−67.378	−6.247	1.00	39.74	C
ATOM	3899	CD	ARG	A	488	4.452	−68.385	−7.105	1.00	41.72	C
ATOM	3900	NE	ARG	A	488	4.778	−69.796	−7.053	1.00	45.36	N
ATOM	3901	CZ	ARG	A	488	4.321	−70.621	−6.118	1.00	45.93	C
ATOM	3902	NH1	ARG	A	488	3.524	−70.156	−5.149	1.00	42.85	N
ATOM	3903	NH2	ARG	A	488	4.660	−71.905	−6.166	1.00	42.92	N
ATOM	3904	C	ARG	A	488	7.748	−66.122	−5.077	1.00	37.95	C
ATOM	3905	O	ARG	A	488	8.613	−66.332	−4.618	1.00	38.39	O
ATOM	3906	N	GLU	A	489	7.010	−65.305	−4.332	1.00	38.32	N
ATOM	3907	CA	GLU	A	489	−2.861	−65.286	−2.861	1.00	41.60	C
ATOM	3908	CB	GLU	A	489	7.387	−63.879	−2.349	1.00	40.94	C
ATOM	3909	CG	GLU	A	489	8.726	−63.357	−2.858	1.00	52.25	C
ATOM	3910	CD	GLU	A	489	9.054	−61.922	−2.453	1.00	55.98	C
ATOM	3911	OE1	GLU	A	489	8.242	−61.256	−1.762	1.00	51.77	O
ATOM	3912	OE2	GLU	A	489	10.150	−61.461	−2.850	1.00	60.06	O
ATOM	3913	C	GLU	A	489	5.743	−65.760	−2.227	1.00	43.12	C
ATOM	3914	O	GLU	A	489	4.657	−65.677	−2.829	1.00	44.57	O
ATOM	3915	N	LYS	A	490	5.843	−66.248	−1.003	1.00	45.49	N
ATOM	3916	CA	LYS	A	490	4.668	−66.568	−0.216	1.00	50.61	C
ATOM	3917	CB	LYS	A	490	5.103	−67.273	1.061	1.00	54.32	C
ATOM	3918	CG	LYS	A	490	5.942	−66.381	1.960	1.00	61.26	C
ATOM	3919	CD	LYS	A	490	6.934	−67.250	2.812	1.00	70.53	C
ATOM	3920	CE	LYS	A	490	7.663	−66.272	3.723	1.00	73.83	C
ATOM	3921	NZ	LYS	A	490	8.899	−66.270	4.298	1.00	79.38	N
ATOM	3922	C	LYS	A	490	3.915	−65.264	0.105	1.00	46.60	C
ATOM	3923	O	LYS	A	490	4.462	−64.268	0.001	1.00	44.43	O
ATOM	3924	N	ASP	A	491	2.647	−65.391	0.457	1.00	44.56	N
ATOM	3925	CA	ASP	A	491	1.862	−64.255	0.960	1.00	41.10	C
ATOM	3926	CB	ASP	A	491	2.485	−63.694	2.247	1.00	47.12	C
ATOM	3927	CG	ASP	A	491	2.770	−64.768	3.276	1.00	48.37	C
ATOM	3928	OD1	ASP	A	491	2.122	−65.841	3.231	1.00	50.02	O
ATOM	3929	OD2	ASP	A	491	3.644	−64.523	4.131	1.00	50.54	O
ATOM	3930	C	ASP	A	491	1.642	−63.113	−0.012	1.00	35.15	C
ATOM	3931	O	ASP	A	491	1.450	−61.970	0.416	1.00	35.05	O
ATOM	3932	N	ARG	A	492	1.672	−63.404	−1.302	1.00	31.66	N
ATOM	3933	CA	ARG	A	492	1.314	−62.414	−2.311	1.00	34.92	C
ATOM	3934	CB	ARG	A	492	2.481	−61.413	−2.595	1.00	35.19	C
ATOM	3935	CG	ARG	A	492	3.396	−61.786	−3.757	1.00	34.73	C
ATOM	3936	CD	ARG	A	492	4.670	−60.943	−3.817	1.00	33.87	C
ATOM	3937	NE	ARG	A	492	5.618	−61.463	−4.805	1.00	31.81	N
ATOM	3938	CZ	ARG	A	492	6.690	−60.799	−5.253	1.00	35.40	C
ATOM	3939	NH1	ARG	A	492	6.962	−59.575	−4.802	1.00	37.29	N
ATOM	3940	NH2	ARG	A	492	7.507	−61.354	−6.143	1.00	28.75	N
ATOM	3941	C	ARG	A	492	0.875	−63.161	−3.563	1.00	36.40	C
ATOM	3942	O	ARG	A	492	1.112	−64.371	−3.679	1.00	42.82	O
ATOM	3943	N	ASP	A	493	0.236	−62.447	−4.489	1.00	35.83	N
ATOM	3944	CA	ASP	A	493	−0.174	−62.983	−5.781	1.00	35.97	C
ATOM	3945	CB	ASP	A	493	−0.495	−61.836	−6.751	1.00	36.54	C
ATOM	3946	CG	ASP	A	493	−1.211	−62.307	−8.034	1.00	42.41	C
ATOM	3947	CD1	ASP	A	493	−0.871	−63.374	−8.611	1.00	38.14	O
ATOM	3948	CD2	ASP	A	493	−2.121	−61.572	−8.485	1.00	48.59	O
ATOM	3949	C	ASP	A	493	0.928	−63.844	−6.372	1.00	37.49	C
ATOM	3950	O	ASP	A	493	2.053	−63.369	−6.520	1.00	37.96	O
ATOM	3951	N	PRO	A	494	0.595	−65.101	−6.750	1.00	39.13	N
ATOM	3952	CA	PRO	A	494	1.551	−66.068	−7.300	1.00	36.87	C
ATOM	3953	CB	PRO	A	494	0.694	−67.311	−7.498	1.00	35.08	C
ATOM	3954	CG	PRO	A	494	−0.409	−67.138	−6.522	1.00	37.17	C
ATOM	3955	CD	PRO	A	494	−0.748	−65.701	−6.668	1.00	37.50	C
ATOM	3956	C	PRO	A	494	2.149	−65.676	−8.633	1.00	36.26	C
ATOM	3957	O	PRO	A	494	3.051	−66.362	−9.120	1.00	36.47	O
ATOM	3958	N	GLU	A	495	1.643	−64.595	−9.220	1.00	35.71	N
ATOM	3959	CA	GLU	A	495	2.104	−64.331	−10.511	1.00	34.83	C
ATOM	3960	CB	GLU	A	455	1.016	−64.240	−11.550	1.00	37.07	C
ATOM	3961	CG	GLU	A	495	0.760	−65.646	−12.160	1.00	41.88	C
ATOM	3962	CD	GLU	A	495	−0.462	−65.689	−13.091	1.00	46.47	C
ATOM	3963	OE1	GLU	A	495	−1.521	−65.112	−12.765	1.00	45.81	O
ATOM	3964	OE2	GLU	A	495	−0.370	−66.285	−14.181	1.00	54.44	O
ATOM	3965	C	GLU	A	495	2.570	−62.682	−10.391	1.00	34.87	C
ATOM	3966	O	GLU	A	495	2.989	−62.083	−11.385	1.00	35.52	O
ATOM	3967	N	ALA	A	496	2.520	−62.121	−9.184	1.00	30.93	N
ATOM	3968	CA	ALA	A	496	3.054	−60.776	−8.977	1.00	31.20	C
ATOM	3969	CB	ALA	A	496	3.016	−60.391	−7.516	1.00	31.15	C
ATOM	3970	C	ALA	A	496	4.470	−60.559	−9.559	1.00	30.85	C
ATOM	3971	O	ALA	A	496	4.729	−59.485	−10.109	1.00	27.96	O
ATOM	3972	N	GLN	A	497	5.369	−61.557	−9.451	1.00	33.19	N
ATOM	3973	CA	GLN	A	497	6.779	−61.460	−9.983	1.00	30.30	C
ATOM	3974	CB	GLN	A	497	7.404	−62.832	−10.297	1.00	31.86	C
ATOM	3975	CG	GLN	A	497	7.138	−64.021	−9.423	1.00	33.67	C
ATOM	3976	CD	GLN	A	497	5.719	−64.517	−9.437	1.00	34.62	C
ATOM	3977	OE1	GLN	A	497	4.907	−64.067	−8.656	1.00	36.96	O
ATOM	3978	NE2	GLN	A	497	5.438	−65.496	−10.269	1.00	36.08	N
ATOM	3979	C	GLN	A	497	6.748	−60.841	−11.365	1.00	31.62	C
ATOM	3980	O	GLN	A	497	7.661	−60.139	−11.756	1.00	32.19	O
ATOM	3981	N	PHE	A	498	5.708	−61.171	−12.130	1.00	29.25	N
ATOM	3982	CA	PHE	A	498	5.687	−60.860	−13.554	1.00	29.07	C
ATOM	3983	CB	PHE	A	498	4.824	−61.846	−14.318	1.00	27.54	C
ATOM	3984	CG	PHE	A	498	5.413	−63.213	−14.416	1.00	28.29	C
ATOM	3985	CD1	PHE	A	498	6.410	−63.485	−15.341	1.00	28.96	C
ATOM	3986	CE1	PHE	A	498	6.951	−64.758	−15.447	1.00	28.43	C
ATOM	3987	CZ	PHE	A	498	6.468	−65.776	−14.644	1.00	30.85	C
ATOM	3988	CE2	PHE	A	498	5.469	−65.518	−13.705	1.00	30.13	C
ATOM	3989	CD2	PHE	A	498	4.951	−64.245	−13.592	1.00	28.44	C
ATOM	3990	C	PHE	A	498	5.145	−59.485	−13.837	1.00	27.10	C
ATOM	3991	O	PHE	A	498	5.143	−59.059	−14.984	1.00	26.18	O
ATOM	3992	N	GLU	A	499	4.712	−58.784	−12.798	1.00	25.45	N
ATOM	3993	CA	GLU	A	499	4.082	−57.497	−13.000	1.00	29.05	C
ATOM	3994	CB	GLU	A	499	2.645	−57.502	−12.428	1.00	28.23	C
ATOM	3995	CG	GLU	A	499	1.782	−58.598	−12.987	1.00	26.37	C
ATOM	3996	CD	GLU	A	499	0.279	−58.362	−12.759	1.00	28.75	C
ATOM	3997	OE1	GLU	A	499	−0.151	−58.269	−11.610	1.00	29.19	O
ATOM	3998	OE2	GLU	A	499	−0.486	−59.282	−13.731	1.00	28.50	O
ATOM	3999	C	GLU	A	499	4.909	−56.358	−12.400	1.00	30.60	C
ATOM	4000	O	GLU	A	499	4.329	−55.395	−11.880	1.00	31.00	O
ATOM	4001	N	MET	A	500	6.241	−56.465	−12.506	1.00	28.19	N
ATOM	4002	CA	MET	A	500	7.130	−55.454	−12.022	1.00	30.11	C
ATOM	4003	CB	MET	A	500	7.426	−55.641	−10.526	1.00	30.81	C
ATOM	4004	CG	MET	A	500	8.197	−56.909	−10.199	1.00	30.79	C
ATOM	4005	SD	MET	A	500	8.320	−57.083	−8.419	1.00	34.96	O
ATOM	4006	CE	MET	A	500	6.596	−57.237	−7.925	1.00	36.05	C
ATOM	4007	C	MET	A	500	8.424	−55.474	−12.830	1.00	32.05	C
ATOM	4008	O	MET	A	500	8.827	−56.522	−13.308	1.00	34.96	O
ATOM	4009	N	PRO	A	501	9.060	−54.298	−13.011	1.00	29.79	N
ATOM	4010	CA	PRO	A	501	10.265	−54.200	−13.810	1.00	29.34	C
ATOM	4011	CB	PRO	A	501	10.260	−52.238	−14.258	1.00	29.52	C
ATOM	4012	CG	PRO	A	501	9.508	−52.004	−13.184	1.00	29.84	C
ATOM	4013	CD	PRO	A	501	8.596	−52.984	−12.517	1.00	28.13	C
ATOM	4014	C	PRO	A	501	11.531	−54.495	−12.981	1.00	30.97	C
ATOM	4015	O	PRO	A	501	11.594	−54.161	−11.802	1.00	32.57	O
ATOM	4016	N	TYR	A	502	12.508	−55.155	−13.588	1.00	30.83	N
ATOM	4017	CA	TYR	A	502	13.753	−55.463	−12.902	1.00	30.46	C
ATOM	4018	CB	TYR	A	502	14.013	−56.967	−12.883	1.00	30.47	C
ATOM	4019	CG	TYR	A	502	12.905	−57.764	−12.195	1.00	31.04	C
ATOM	4020	CD1	TYR	A	502	11.805	−58.257	−12.923	1.00	30.47	C
ATOM	4021	CE1	TYR	A	502	10.790	−58.987	−12.285	1.00	31.23	C
ATOM	4022	CZ	TYR	A	502	10.900	−59.252	−10.922	1.00	31.45	C
ATOM	4023	OH	TYR	A	502	9.931	−59.982	−10.292	1.00	31.22	O
ATOM	4024	CE2	TYR	A	502	11.997	−58.803	−10.196	1.00	28.76	C
ATOM	4025	CD2	TYR	A	502	12.980	−58.064	−10.834	1.00	28.41	C
ATOM	4026	C	TYR	A	502	14.894	−54.727	−13.574	1.00	29.66	C
ATOM	4027	O	TYR	A	502	14.991	−54.687	−14.802	1.00	31.18	O
ATOM	4028	N	VAL	A	503	15.710	−54.683	−12.767	1.00	28.71	N
ATOM	4029	CA	VAL	A	503	17.034	−53.648	−13.207	1.00	30.59	C
ATOM	4030	CB	VAL	A	503	17.683	−52.671	−12.200	1.00	29.00	C
ATOM	4031	CG1	VAL	A	503	19.157	−52.420	−12.555	1.00	30.35	C
ATOM	4032	CG2	VAL	A	503	16.922	−51.373	−12.209	1.00	25.64	C
ATOM	4033	C	VAL	A	503	17.871	−54.912	−13.303	1.00	29.24	C
ATOM	4034	O	VAL	A	503	17.941	−55.671	−12.350	1.00	31.92	O
ATOM	4035	N	VAL	A	504	18.485	−55.344	−14.453	1.00	31.25	N
ATOM	4036	CA	VAL	A	504	19.204	−56.382	−14.697	1.00	31.48	C
ATOM	4037	CB	VAL	A	504	18.220	−57.536	−15.114	1.00	32.67	C
ATOM	4038	CG1	VAL	A	504	17.170	−57.653	−16.138	1.00	29.79	C
ATOM	4039	CG2	VAL	A	504	18.981	−58.734	−15.657	1.00	27.95	C
ATOM	4040	C	VAL	A	504	20.208	−56.100	−15.795	1.00	34.79	C
ATOM	4041	O	VAL	A	504	19.877	−55.393	−16.743	1.00	34.45	O
ATOM	4042	N	ARG	A	505	21.431	−56.633	−15.666	1.00	39.33	N
ATOM	4043	CA	ARG	A	505	22.403	−56.608	−16.766	1.00	38.74	C
ATOM	4044	CB	ARG	A	505	23.850	−56.827	−16.282	1.00	43.16	C
ATOM	4045	CG	ARG	A	505	24.861	−55.887	−16.938	1.00	45.32	C
ATOM	4046	CD	ARG	A	505	25.335	−56.205	−18.354	1.00	45.45	C
ATOM	4047	NE	ARG	A	505	24.305	−56.368	−19.394	1.00	48.77	N
ATOM	4048	CZ	ARG	A	505	23.803	−55.401	−20.172	1.00	49.01	C
ATOM	4049	NH1	ARG	A	505	22.894	−55.708	−21.091	1.00	46.88	N
ATOM	4050	NH2	ARG	A	505	24.182	−54.132	−20.038	1.00	50.01	N
ATOM	4051	C	ARG	A	505	22.061	−57.725	−17.732	1.00	40.57	C
ATOM	4052	O	ARG	A	505	22.560	−58.848	−17.596	1.00	40.29	O
ATOM	4053	N	LEU	A	506	21.213	−57.418	−18.707	1.00	40.02	N
ATOM	4054	CA	LEU	A	506	20.765	−58.410	−19.662	1.00	39.25	C
ATOM	4055	CB	LEU	A	506	19.883	−57.744	−20.712	1.00	39.06	C
ATOM	4056	CG	LEU	A	506	18.672	−56.918	−20.261	1.00	37.20	C
ATOM	4057	CD1	LEU	A	506	18.197	−56.151	−21.466	1.00	36.14	C
ATOM	4058	CD2	LEU	A	506	17.567	−57.792	−19.705	1.00	33.90	C
ATOM	4059	C	LEU	A	506	21.968	−59.098	−20.328	1.00	40.41	C
ATOM	4060	O	LEU	A	506	22.756	−58.455	−20.993	1.00	41.20	O
ATOM	4061	N	HIS	A	507	22.090	−60.408	−20.158	1.00	39.86	N
ATOM	4062	CA	HIS	A	507	23.206	−61.123	−20.726	1.00	41.33	C
ATOM	4063	CB	HIS	A	507	24.111	−61.615	−19.618	1.00	41.01	C
ATOM	4064	CG	HIS	A	507	25.409	−62.156	−20.117	1.00	44.77	C
ATOM	4065	ND1	HIS	A	507	26.253	−61.427	−20.930	1.00	45.57	N
ATOM	4066	CE1	HIS	A	507	27.316	−62.155	−21.217	1.00	45.15	C
ATOM	4067	NE2	HIS	A	507	27.193	−63.326	−20.619	1.00	44.56	N
ATOM	4068	CD2	HIS	A	507	26.006	−63.355	−19.929	1.00	43.35	C
ATOM	4069	C	HIS	A	507	22.832	−62.276	−21.678	1.00	44.65	C
ATOM	4070	O	HIS	A	507	23.106	−62.204	−22.865	1.00	44.60	O
ATOM	4071	N	ASN	A	508	22.245	−63.349	−21.157	1.00	45.23	N
ATOM	4072	CA	ASN	A	508	21.799	−64.451	−22.006	1.00	45.67	C
ATOM	4073	CB	ASN	A	508	21.888	−65.793	−21.234	1.00	44.08	C
ATOM	4074	CG	ASN	A	508	21.436	−67.003	−22.053	1.00	40.91	C
ATOM	4075	OD1	ASN	A	508	21.490	−67.031	−23.287	1.00	39.33	O
ATOM	4076	ND2	ASN	A	508	20.990	−68.016	−21.349	1.00	41.66	N
ATOM	4077	C	ASN	A	508	20.385	−64.127	−22.538	1.00	45.54	C
ATOM	4078	O	ASN	A	508	19.371	−64.516	−21.951	1.00	43.77	O
ATOM	4079	N	PHE	A	509	20.335	−63.365	−23.626	1.00	43.32	N
ATOM	4080	CA	PHE	A	509	19.062	−62.935	−24.203	1.00	44.36	C
ATOM	4081	CB	PHE	A	509	18.508	−61.683	−23.477	1.00	42.00	C
ATOM	4082	CG	PHE	A	509	19.154	−60.378	−23.887	1.00	38.12	C
ATOM	4083	CD1	PHE	A	509	20.506	−60.317	−23.606	1.00	38.89	C
ATOM	4084	CE1	PHE	A	509	21.095	−58.909	−23.987	1.00	36.99	C
ATOM	4085	CZ	PHE	A	509	20.336	−57.943	−24.642	1.00	37.52	C
ATOM	4086	CE2	PHE	A	509	18.984	−58.193	−24.908	1.00	37.76	C
ATOM	4087	CD2	PHE	A	509	18.412	−59.400	−24.531	1.00	36.25	C
ATOM	4088	C	PHE	A	509	19.215	−62.659	−25.687	1.00	44.46	C
ATOM	4089	O	PHE	A	509	20.332	−62.559	−26.193	1.00	47.70	O
ATOM	4090	N	HIS	A	510	18.089	−62.540	−26.379	1.00	42.40	N
ATOM	4091	CA	HIS	A	510	18.089	−62.135	−27.774	1.00	43.17	C
ATOM	4092	CB	HIS	A	510	17.621	−63.287	−28.683	1.00	39.61	C
ATOM	4093	CG	HIS	A	510	17.634	−62.948	−30.137	1.00	37.88	C
ATOM	4094	ND1	HIS	A	510	16.864	−63.622	−31.065	1.00	38.99	N
ATOM	4095	CE1	HIS	A	510	17.083	−63.105	−32.264	1.00	42.21	C
ATOM	4096	NE2	HIS	A	510	17.963	−62.118	−32.148	1.00	40.22	N
ATOM	4097	CD2	HIS	A	510	18.317	−61.996	−30.826	1.00	39.79	C
ATOM	4098	C	HIS	A	510	17.185	−60.926	−27.912	1.00	45.60	C
ATOM	4099	O	HIS	A	510	16.029	−60.953	−27.458	1.00	45.31	O
ATOM	4100	N	GLN	A	511	17.719	−59.857	−28.502	1.00	45.50	N
ATOM	4101	CA	GLN	A	511	16.911	−58.680	−28.753	1.00	43.67	C
ATOM	4102	CB	GLN	A	511	17.737	−57.420	−28.721	1.00	42.21	C
ATOM	4103	CG	GLN	A	511	16.874	−56.224	−28.396	1.00	43.04	C
ATOM	4104	CD	GLN	A	511	17.653	−54.935	−28.366	1.00	42.68	C
ATOM	4105	OE1	GLN	A	511	17.941	−54.345	−29.419	1.00	39.62	O
ATOM	4106	NE2	GLN	A	511	17.980	−54.472	−27.154	1.00	41.26	N
ATOM	4107	C	GLN	A	511	16.206	−58.784	−30.085	1.00	46.68	C
ATOM	4108	O	GLN	A	511	16.852	−58.863	−31.140	1.00	42.58	O
ATOM	4109	N	LEU	A	512	14.872	−58.771	−30.025	1.00	45.83	N
ATOM	4110	CA	LEU	A	512	14.041	−59.100	−31.179	1.00	40.57	C
ATOM	4111	CB	LEU	A	512	12.719	−59.670	−30.705	1.00	39.95	C
ATOM	4112	CG	LEU	A	512	12.560	−61.164	−30.411	1.00	40.80	C
ATOM	4113	CD1	LEU	A	512	13.837	−61.958	−30.128	1.00	40.74	C
ATOM	4114	CD2	LEU	A	512	11.549	−61.331	−29.296	1.00	38.75	C
ATOM	4115	C	LEU	A	512	13.815	−57.952	−32.166	1.00	41.97	C
ATOM	4116	O	LEU	A	512	13.484	−58.212	−33.327	1.00	41.41	O
ATOM	4117	N	SER	A	513	13.974	−56.695	−31.722	1.00	39.59	N
ATOM	4118	CA	SER	A	513	13.777	−55.530	−32.602	1.00	37.05	C
ATOM	4119	CB	SER	A	513	12.286	−55.213	−32.764	1.00	39.61	C
ATOM	4120	OG	SER	A	513	12.050	−54.147	−33.697	1.00	36.95	O
ATOM	4121	C	SER	A	513	14.536	−54.299	−32.083	1.00	41.65	C
ATOM	4122	O	SER	A	513	14.913	−54.242	−30.910	1.00	44.45	O
ATOM	4123	N	ALA	A	514	14.762	−53.307	−32.944	1.00	40.16	N
ATOM	4124	CA	ALA	A	514	15.467	−52.093	−32.520	1.00	42.63	C
ATOM	4125	CB	ALA	A	514	15.704	−51.175	−33.713	1.00	37.56	C
ATOM	4126	C	ALA	A	514	14.644	−51.359	−31.447	1.00	45.31	C
ATOM	4127	O	ALA	A	514	13.410	−51.299	−31.560	1.00	47.27	O
ATOM	4128	N	PRO	A	515	15.316	−50.777	−30.423	1.00	44.84	N
ATOM	4129	CA	PRO	A	515	14.586	−50.022	−29.388	1.00	41.50	C
ATOM	4130	CB	PRO	A	515	15.699	49.462	−28.502	1.00	41.79	C
ATOM	4131	CG	PRO	A	515	16.843	−50.420	−28.680	1.00	40.80	C
ATOM	4132	CD	PRO	A	515	16.762	−50.836	−30.133	1.00	42.94	C
ATOM	4133	C	PRO	A	515	13.796	−48.896	−29.997	1.00	40.86	C
ATOM	4134	O	PRO	A	515	14.194	−48.361	−31.026	1.00	44.27	O
ATOM	4135	N	GLN	A	516	12.665	−48.549	−29.396	1.00	39.37	N
ATOM	4136	CA	GLN	A	516	11.897	−47.394	−29.894	1.00	39.21	C
ATOM	4137	CB	GLN	A	516	10.652	−47.842	−30.674	1.00	38.84	C
ATOM	4138	CG	GLN	A	516	10.942	−48.305	−32.102	1.00	38.41	C
ATOM	4139	CD	GLN	A	516	9.687	−48.727	−32.842	1.00	42.85	C
ATOM	4140	OE1	GLN	A	516	8.667	−48.010	−32.831	1.00	42.94	O
ATOM	4141	NE2	GLN	A	516	9.741	−49.902	−33.479	1.00	38.68	N
ATOM	4142	C	GLN	A	516	11.548	−46.479	−28.730	1.00	36.08	C
ATOM	4143	O	GLN	A	516	11.438	−46.959	−27.604	1.00	36.64	O
ATOM	4144	N	PRO	A	517	11.445	−45.165	−28.983	1.00	31.09	N
ATOM	4145	CA	PRO	A	517	11.191	−44.228	−27.911	1.00	32.73	C
ATOM	4146	CB	PRO	A	517	11.123	−42.856	−28.627	1.00	32.81	C
ATOM	4147	CG	PRO	A	517	11.039	−43.157	−30.087	1.00	31.16	C
ATOM	4148	CD	PRO	A	517	11.713	−44.485	−30.262	1.00	31.86	C
ATOM	4149	C	PRO	A	517	9.856	−44.544	−27.267	1.00	35.76	C
ATOM	4150	O	PRO	A	517	8.943	−44.984	−27.952	1.00	35.37	O
ATOM	4151	N	CYS	A	518	9.754	−44.341	−25.958	1.00	36.48	N
ATOM	4152	CA	CYS	A	518	8.532	−44.660	−25.261	1.00	39.50	C
ATOM	4153	CB	CYS	A	518	8.780	−45.766	−24.226	1.00	39.12	C
ATOM	4154	SG	CYS	A	518	7.268	−46.328	−23.389	1.00	36.16	S
ATOM	4155	C	CYS	A	518	7.917	−43.378	−24.654	1.00	39.96	C
ATOM	4156	O	CYS	A	518	7.022	−42.780	−25.248	1.00	36.14	O
ATOM	4157	N	PHE	A	519	8.414	−42.957	−23.491	1.00	39.47	N
ATOM	4158	CA	PHE	A	519	7.909	−41.164	−22.817	1.00	36.32	C
ATOM	4159	CB	PHE	A	519	7.529	−42.067	−21.369	1.00	35.86	C
ATOM	4160	CG	PHE	A	519	6.456	−43.099	−21.226	1.00	35.98	C
ATOM	4161	CD1	PHE	A	519	5.392	−43.157	−22.135	1.00	36.14	C
ATOM	4162	CE1	PHE	A	519	4.396	−44.111	−22.005	1.00	34.99	C
ATOM	4163	CZ	PHE	A	519	4.444	−45.008	−20.953	1.00	35.02	C
ATOM	4164	CE2	PHE	A	519	5.493	−44.951	−20.033	1.00	36.12	C
ATOM	4165	CD2	PHE	A	519	6.490	−43.995	−20.172	1.00	34.55	C
ATOM	4166	C	PHE	A	519	8.967	−40.705	−22.798	1.00	35.09	C
ATOM	4167	O	PHE	A	519	10.177	−41.016	−22.683	1.00	37.07	O
ATOM	4168	N	ATHR	A	520	8.527	−39.455	−22.879	0.50	33.56	N
ATOM	4169	N	BTHR	A	520	8.545	−39.452	−22.916	0.50	34.65	N
ATOM	4170	CA	ATHR	A	520	9.444	−38.323	−22.879	0.50	33.17	C
ATOM	4171	CA	BTHR	A	520	9.492	−38.343	−22.864	0.50	35.14	C
ATOM	4172	CB	ATHR	A	520	9.646	−37.791	−24.317	0.50	32.87	C
ATOM	4173	CB	BTHR	A	520	9.873	−37.849	−24.286	0.50	36.15	C
ATOM	4174	OG1	ATHR	A	520	10.332	−38.781	−25.096	0.50	30.07	O
ATOM	4175	OG1	BTHR	A	520	10.858	−36.807	−24.199	0.50	36.12	O
ATOM	4176	CG2	ATHR	A	520	10.452	−36.486	−24.319	0.50	32.50	C
ATOM	4177	CG2	BTHR	A	520	8.648	−37.341	−25.040	0.50	35.78	C
ATOM	4178	C	ATHR	A	520	8.985	−37.208	−21.937	0.50	33.94	C
ATOM	4179	C	BTHR	A	520	9.007	−37.197	−21.971	0.50	35.15	C
ATOM	4180	C	ATHR	A	520	7.794	−36.857	−21.898	0.50	35.23	O
ATOM	4181	O	BTHR	A	520	7.824	−36.823	−21.996	0.50	36.56	O
ATOM	4182	N	PHE	A	521	9.929	−36.662	−21.174	1.00	33.75	N
ATOM	4183	CA	PHE	A	521	9.661	−35.513	−20.303	1.00	33.24	C
ATOM	4184	CB	PHE	A	521	9.693	−35.932	−18.815	1.00	30.74	C
ATOM	4185	CG	PHE	A	521	8.607	−36.912	−18.462	1.00	32.01	C
ATOM	4186	CD1	PHE	A	521	7.355	−36.460	−18.015	1.00	30.92	C
ATOM	4187	CE1	PHE	A	521	6.328	−37.358	−17.745	1.00	30.82	C
ATOM	4188	CZ	PHE	A	521	6.529	−38.716	−17.939	1.00	32.01	C
ATOM	4189	CE2	PHE	A	521	7.773	−39.176	−18.398	1.00	32.28	C
ATOM	4190	CD2	PHE	A	521	8.795	−38.276	−18.663	1.00	29.37	C
ATOM	4191	C	PHE	A	521	10.649	−34.393	−20.568	1.00	36.59	C
ATOM	4192	C	PHE	A	521	11.829	−34.649	−20.869	1.00	40.93	O
ATOM	4193	N	SER	A	522	10.167	−33.159	−20.427	1.00	39.78	N
ATOM	4194	CA	SER	A	522	10.973	−31.937	−20.583	1.00	43.55	C
ATOM	4195	CB	SER	A	522	10.441	−31.099	−21.751	1.00	40.56	C
ATOM	4196	CG	SER	A	522	10.918	−31.605	−22.988	1.00	43.57	O
ATOM	4197	C	SER	A	522	10.945	−31.100	−19.316	1.00	41.90	C
ATOM	4198	O	SER	A	522	9.923	−31.042	−18.628	1.00	45.51	O
ATOM	4199	N	HIS	A	523	12.058	−30.435	−19.012	1.00	43.57	N
ATOM	4200	CA	HIS	A	523	12.131	−29.590	−17.814	1.00	43.54	C
ATOM	4201	CB	HIS	A	523	12.829	−30.341	−16.675	1.00	42.00	C
ATOM	4202	CG	HIS	A	523	12.087	−31.566	−16.235	1.00	47.01	C
ATOM	4203	ND1	HIS	A	523	10.868	−31.506	−15.592	1.00	44.65	N
ATOM	4204	OE1	HIS	A	523	10.442	−32.734	−15.352	1.00	47.71	C
ATOM	4205	NE2	HIS	A	523	11.341	−33.587	−15.813	1.00	46.32	N
ATOM	4206	CD2	HIS	A	523	12.376	−32.882	−16.374	1.00	45.58	C
ATOM	4207	C	HIS	A	523	12.794	−28.241	−18.084	1.00	44.54	C
ATOM	4208	O	HIS	A	523	13.838	−28.189	−18.728	1.00	48.30	O
ATOM	4209	N	PRO	A	524	12.194	−27.139	−17.599	1.00	46.37	N
ATOM	4210	CA	PRO	A	524	10.916	−27.030	−16.896	1.00	46.46	C
ATOM	4211	CB	PRO	A	524	10.834	−25.532	−16.554	1.00	48.85	C
ATOM	4212	CG	PRO	A	524	11.503	−24.866	−17.569	1.00	46.66	C
ATOM	4213	CD	PRO	A	524	12.861	−25.823	−17.694	1.00	45.78	C
ATOM	4214	C	PRO	A	524	9.740	−27.389	−17.784	1.00	50.51	C
ATOM	4215	O	PRO	A	524	9.874	−27.461	−19.013	1.00	51.04	O
ATOM	4216	N	ASN	A	525	8.588	−27.585	−17.160	1.00	54.63	N
ATOM	4217	CA	ASN	A	525	7.393	−28.005	−17.870	1.00	62.29	C
ATOM	4218	CB	ASN	A	525	6.746	−29.178	−17.123	1.00	61.80	C
ATOM	4219	CG	ASN	A	525	5.631	−29.883	−17.904	1.00	62.77	C
ATOM	4220	OD1	ASN	A	525	5.123	−30.897	−17.459	1.00	61.63	O
ATOM	4221	ND2	ASN	A	525	5.233	−29.299	−19.045	1.00	55.86	N
ATOM	4222	C	ASN	A	525	6.450	−26.818	−18.008	1.00	68.35	C
ATOM	4223	O	ASN	A	525	5.790	−26.401	−17.054	1.00	66.72	O
ATOM	4224	N	ARG	A	526	6.403	−26.275	−19.217	1.00	80.73	N
ATOM	4225	CA	ARG	A	526	5.609	−25.081	−19.508	1.00	90.30	C
ATOM	4226	CB	ARG	A	526	6.272	−24.254	−20.627	1.00	92.13	C
ATOM	4227	CG	ARG	A	526	7.027	−25.057	−21.690	1.00	92.81	C
ATOM	4228	CD	ARG	A	526	8.126	−24.237	−22.367	1.00	90.84	C
ATOM	4229	NE	ARG	A	576	9.273	−23.967	−21.487	1.00	95.28	N
ATOM	4230	CZ	ARG	A	526	9.427	−22.880	−20.719	1.00	92.60	C
ATOM	4231	NH1	ARG	A	526	8.506	−21.920	−20.697	1.00	89.70	N
ATOM	4232	NH2	ARG	A	526	10.513	−22.748	−19.961	1.00	82.19	N
ATOM	4233	C	ARG	A	526	4.117	−25.348	−19.797	1.00	95.58	C
ATOM	4234	O	ARG	A	526	3.380	−24.429	−20.167	1.00	100.44	O
ATOM	4235	N	ASP	A	527	3.682	−26.598	−19.615	1.00	95.61	N
ATOM	4236	CA	ASP	A	527	2.272	−26.982	−19.762	1.00	95.35	C
ATOM	4237	CB	ASP	A	527	2.097	−28.494	−19.564	1.00	97.26	C
ATOM	4238	CG	ASP	A	527	2.080	−29.264	−20.877	1.00	98.31	C
ATOM	4239	OD1	ASP	A	527	1.740	−28.659	−21.919	1.00	100.45	O
ATOM	4240	OD2	ASP	A	527	2.394	−30.477	−20.864	1.00	90.93	O
ATOM	4241	C	ASP	A	527	1.360	−26.230	−18.787	1.00	95.47	C
ATOM	4242	O	ASP	A	527	1.672	−26.145	−17.594	1.00	89.43	O
ATOM	4243	N	PRO	A	528	0.229	−25.685	−19.290	1.00	98.66	N
ATOM	4244	CA	PRO	A	528	−0.692	−24.960	−18.401	1.00	97.50	C
ATOM	4245	CB	PRO	A	528	−1.807	−24.469	−19.344	1.00	95.96	C
ATOM	4246	CG	PRO	A	528	−1.704	−25.315	−20.570	1.00	99.62	C
ATOM	4247	CD	PRO	A	528	−0.272	−25.765	−20.678	1.00	97.80	C
ATOM	4248	C	PRO	A	528	−1.239	−25.911	−17.345	1.00	97.70	C
ATOM	4249	O	PRO	A	528	−1.247	−25.586	−16.155	1.00	93.98	O
ATOM	4250	N	MET	A	529	−1.687	−27.277	−17.804	1.00	101.46	N
ATOM	4251	CA	MET	A	529	−2.020	−28.199	−16.946	1.00	100.10	C
ATOM	4252	CB	MET	A	529	−3.377	−28.810	−17.339	1.00	111.36	C
ATOM	4253	CG	MET	A	529	−4.620	−27.954	−17.072	1.00	113.77	C
ATOM	4254	SD	MET	A	529	−5.132	−26.777	−18.355	1.00	118.43	S
ATOM	4255	CE	MET	A	529	−5.144	−27.758	−19.860	1.00	118.56	C
ATOM	4256	C	MET	A	529	−0.905	−29.228	−17.131	1.00	93.15	C
ATOM	4257	O	MET	A	529	−0.669	−29.718	−18.244	1.00	91.84	O
ATOM	4258	N	ILE	A	530	−0.197	−29.532	−16.051	1.00	79.63	N
ATOM	4259	CA	ILE	A	530	0.832	−30.554	−16.112	1.00	72.45	C
ATOM	4260	CB	ILE	A	530	1.910	−30.354	−15.025	1.00	76.57	C
ATOM	4261	CG1	ILE	A	530	2.721	−29.173	−15.291	1.00	74.40	C
ATOM	4262	CD1	ILE	A	530	3.450	−28.532	−14.073	1.00	69.02	C
ATOM	4263	CG2	ILE	A	530	2.821	−31.585	−14.934	1.00	76.35	C
ATOM	4264	C	ILE	A	530	0.188	−31.927	−15.940	1.00	66.86	C
ATOM	4265	O	ILE	A	530	−0.444	−32.195	−14.912	1.00	62.93	O
ATOM	4266	N	ASP	A	531	0.342	−32.787	−16.949	1.00	56.94	N
ATOM	4267	CA	ASP	A	531	0.004	−34.199	−16.785	1.00	51.67	C
ATOM	4268	CB	ASP	A	531	−1.254	−34.554	−17.557	1.00	53.38	C
ATOM	4269	CG	ASP	A	531	−1.838	−35.362	−17.110	1.00	59.11	C
ATOM	4270	OD1	ASP	A	531	−1.152	−36.684	−16.362	1.00	62.03	O
ATOM	4271	OD2	ASP	A	531	−2.979	−36.174	−17.500	1.00	62.19	O
ATOM	4272	C	ASP	A	531	1.157	−35.202	−17.079	1.00	42.39	C
ATOM	4273	O	ASP	A	531	1.644	−35.329	−18.198	1.00	35.69	O
ATOM	4274	N	ASN	A	532	1.574	−35.921	−16.052	1.00	37.60	N
ATOM	4275	CA	ASN	A	532	2.673	−36.875	−16.215	1.00	34.42	C
ATOM	4276	CB	ASN	A	532	3.589	−36.862	−15.010	1.00	33.17	C
ATOM	4277	CG	ASN	A	532	4.436	−35.601	−14.978	1.00	35.29	C
ATOM	4278	OD1	ASN	A	532	4.699	−34.996	−16.037	1.00	33.71	O
ATOM	4279	ND2	ASN	A	532	4.850	−35.183	−13.789	1.00	34.82	N
ATOM	4280	C	ASN	A	532	2.304	−38.274	−16.663	1.00	33.58	C
ATOM	4281	O	ASN	A	532	3.199	−39.029	−17.029	1.00	30.98	O
ATOM	4282	N	ASN	A	533	0.996	−38.390	−16.676	1.00	29.27	N
ATOM	4283	CA	ASN	A	533	0.513	−39.852	−17.201	1.00	29.95	C
ATOM	4284	CB	ASN	A	533	−0.977	−40.021	−16.924	1.00	33.75	C
ATOM	4285	CG	ASN	A	533	−1.294	−40.039	−15.450	1.00	34.04	C
ATOM	4286	OD1	ASN	A	533	−0.487	−40.447	−14.615	1.00	34.90	O
ATOM	4287	ND2	ASN	A	533	−2.468	−39.590	−15.124	1.00	35.65	N
ATOM	4288	C	ASN	A	533	0.742	−39.979	−18.698	1.00	31.47	C
ATOM	4289	O	ASN	A	533	0.837	−38.991	−19.434	1.00	29.88	O
ATOM	4290	N	ARG	A	534	0.829	−41.212	−19.171	1.00	31.06	N
ATOM	4291	CA	ARG	A	534	1.148	−41.423	−20.568	1.00	29.30	C
ATOM	4292	CB	ARG	A	534	2.658	−41.558	−20.735	1.00	32.16	C
ATOM	4293	CG	ARG	A	534	3.467	−40.335	−20.381	1.00	32.37	C
ATOM	4294	CD	ARG	A	534	3.306	−39.306	−21.469	1.00	33.07	C
ATOM	4295	NE	ARG	A	534	4.388	−38.331	−21.407	1.00	37.32	N
ATOM	4296	CZ	ARG	A	534	4.386	−37.251	−20.638	1.00	36.23	C
ATOM	4297	NH1	ARG	A	534	3.366	−36.987	−19.821	1.00	38.45	N
ATOM	4298	NH2	ARG	A	534	5.414	−36.442	−20.688	1.00	35.18	N
ATOM	4299	C	ARG	A	534	0.543	−42.707	−21.022	1.00	31.09	C
ATOM	4300	O	ARG	A	534	0.374	−43.628	−20.210	1.00	35.36	O
ATOM	4301	N	TYR	A	535	0.266	−42.777	−22.322	1.00	31.81	N
ATOM	4302	CA	TYR	A	535	−0.155	−43.982	−23.012	1.00	33.02	C
ATOM	4303	CB	TYR	A	535	−1.664	−43.917	−23.284	1.00	35.14	C
ATOM	4304	CG	TYR	A	535	−2.262	−45.012	−24.172	1.00	38.46	C
ATOM	4305	CD1	TYR	A	535	−1.847	−46.352	−24.082	1.00	40.98	C
ATOM	4306	CE1	TYR	A	535	−2.416	−47.347	−24.879	1.00	38.50	C
ATOM	4307	CZ	TYR	A	535	−3.410	−47.005	−25.779	1.00	40.96	C
ATOM	4308	OH	TYR	A	535	−3.997	−47.969	−26.566	1.00	43.58	O
ATOM	4309	CE2	TYR	A	535	−3.839	−45.691	−25.887	1.00	40.74	C
ATOM	4310	CD2	TYR	A	535	−3.275	−44.711	−25.081	1.00	39.91	C
ATOM	4311	C	TYR	A	535	0.641	−43.972	−24.307	1.00	34.68	C
ATOM	4312	O	TYR	A	535	0.707	−42.958	−24.988	1.00	34.57	O
ATOM	4313	N	CYS	A	536	1.299	−45.072	−24.646	1.00	36.32	N
ATOM	4314	CA	CYS	A	536	2.040	−45.105	−25.915	1.00	34.23	C
ATOM	4315	CB	CYS	A	536	3.491	−44.687	−25.670	1.00	38.37	C
ATOM	4316	SG	CYS	A	536	4.689	−45.411	−26.793	1.00	48.77	S
ATOM	4317	C	CYS	A	536	1.944	−46.467	−26.580	1.00	31.90	C
ATOM	4318	O	CYS	A	536	1.870	−47.475	−25.884	1.00	34.91	O
ATOM	4319	N	THR	A	537	1.942	−46.510	−27.910	1.00	30.78	N
ATOM	4320	CA	THR	A	537	1.737	−47.770	−28.639	1.00	33.05	C
ATOM	4321	CB	THR	A	537	0.396	−47.775	−29.416	1.00	33.07	C
ATOM	4322	OG1	THR	A	537	−0.694	−47.698	−28.483	1.00	35.08	O
ATOM	4323	CG2	THR	A	537	0.221	−49.041	−30.227	1.00	30.45	C
ATOM	4324	C	THR	A	537	2.897	−48.055	−29.571	1.00	35.74	C
ATOM	4325	O	THR	A	537	3.150	−47.277	−30.474	1.00	37.19	O
ATOM	4326	N	LEU	A	538	3.622	−49.154	−29.344	1.00	37.51	N
ATOM	4327	CA	LEU	A	538	4.808	−49.423	−30.161	1.00	36.86	C
ATOM	4328	CB	LEU	A	538	6.076	−49.506	−29.313	1.00	39.51	C
ATOM	4329	CG	LEU	A	538	6.461	−48.231	−28.582	1.00	38.92	C
ATOM	4330	CD1	LEU	A	538	7.347	−48.497	−27.381	1.00	33.86	C
ATOM	4331	CD2	LEU	A	538	7.143	−47.311	−29.564	1.00	45.41	C
ATOM	4332	C	LEU	A	538	4.673	−50.651	−31.037	1.00	36.75	C
ATOM	4333	O	LEU	A	538	4.164	−51.701	−30.609	1.00	38.98	O
ATOM	4334	N	GLU	A	539	5.144	−50.512	−32.269	1.00	38.21	N
ATOM	4335	CA	GLU	A	539	5.106	−51.594	−33.233	1.00	43.00	C
ATOM	4336	CB	GLU	A	539	4.263	−51.207	−34.444	1.00	46.10	C
ATOM	4337	CG	GLU	A	539	2.766	−51.236	−34.142	1.00	50.71	C
ATOM	4338	CD	GLU	A	539	1.916	−50.805	−55.315	1.00	55.28	C
ATOM	4339	OE1	GLU	A	539	1.003	−49.981	−35.117	1.00	64.31	O
ATOM	4340	OE2	GLU	A	539	2.156	−51.284	−36.437	1.00	51.71	O
ATOM	4341	C	GLU	A	539	6.511	−52.033	−33.612	1.00	42.12	C
ATOM	4342	O	GLU	A	539	7.282	−51.278	−34.200	1.00	45.71	O
ATOM	4343	N	PHE	A	540	6.830	−53.258	−33.227	1.00	39.78	N
ATOM	4344	CA	PHE	A	540	8.150	−53.837	−33.426	1.00	37.77	C
ATOM	4345	CB	PHE	A	540	8.627	−54.484	−32.130	1.00	36.04	C
ATOM	4346	CG	PHE	A	540	8.925	−53.483	−31.032	1.00	38.82	C
ATOM	4347	CD1	PHE	A	540	10.083	−52.694	−31.072	1.00	33.19	C
ATOM	4348	CE1	PHE	A	540	10.354	−51.773	−30.072	1.00	32.53	C
ATOM	4349	CZ	PHE	A	540	9.471	−51.603	−29.015	1.00	33.59	C
ATOM	4350	CE2	PHE	A	540	8.293	−52.358	−28.974	1.00	40.86	C
ATOM	4351	CD2	PHE	A	540	8.026	−53.297	−29.971	1.00	39.80	C
ATOM	4352	C	PHE	A	540	8.162	−54.851	−34.566	1.00	39.93	C
ATOM	4353	O	PHE	A	540	7.672	−55.975	−34.411	1.00	36.72	O
ATOM	4354	N	PRO	A	541	8.726	−54.455	−35.723	1.00	42.33	N
ATOM	4355	CA	PRO	A	541	8.883	−55.410	−36.821	1.00	46.33	C
ATOM	4356	CB	PRO	A	541	9.375	−54.548	−37.993	1.00	43.23	C
ATOM	4357	CG	PRO	A	541	9.963	−53.334	−37.362	1.00	45.71	C
ATOM	4358	CD	PRO	A	541	9.230	−53.115	−36.067	1.00	43.18	C
ATOM	4359	C	PRO	A	541	9.905	−56.438	−36.429	1.00	45.99	C
ATOM	4360	O	PRO	A	541	10.999	−56.081	−36.021	1.00	57.25	O
ATOM	4561	N	VAL	A	542	9.514	−57.700	−36.501	1.00	43.43	N
ATOM	4362	CA	VAL	A	542	10.353	−58.822	−36.124	1.00	53.35	C
ATOM	4363	CB	VAL	A	542	9.691	−59.627	−34.996	1.00	53.79	C
ATOM	4364	CG1	VAL	A	542	10.407	−60.947	−34.740	1.00	53.82	C
ATOM	4365	CG2	VAL	A	542	9.654	−58.798	−33.733	1.00	53.68	C
ATOM	4366	C	VAL	A	542	10.567	−59.723	−37.344	1.00	61.97	C
ATOM	4367	O	VAL	A	542	9.615	−60.011	−38.091	1.00	53.68	O
ATOM	4368	N	GLU	A	543	11.811	−60.162	−37.542	1.00	63.41	N
ATOM	4369	CA	GLU	A	543	12.162	−60.946	−38.719	1.00	68.50	C
ATOM	4370	CB	GLU	A	543	12.864	−60.976	−39.779	100	74.54	C
ATOM	4371	CG	GLU	A	543	14.227	−59.529	−39.380	1.00	86.41	C
ATOM	4372	CD	GLU	A	543	14.129	−58.281	−38.528	1.00	103.86	C
ATOM	4373	OE1	GLU	A	543	13.326	−57.182	−38.876	1.00	112.71	O
ATOM	4374	OE2	GLU	A	543	14.857	−58.199	−37.509	1.00	108.89	O
ATOM	4375	C	GLU	A	543	12.924	−62.260	−38.450	1.00	64.74	C
ATOM	4376	O	GLU	A	543	13.679	−62.725	−39.302	1.00	67.11	O
ATOM	4377	N	VAL	A	544	12.724	−62.853	−37.278	1.00	55.79	N
ATOM	4378	CA	VAL	A	544	13.039	−64.268	−37.089	1.00	58.41	C
ATOM	4379	CB	VAL	A	544	14.307	−64.531	−36.236	1.00	64.35	C
ATOM	4380	CG1	VAL	A	544	15.525	−63.825	−36.820	1.00	78.92	C
ATOM	4381	CG2	VAL	A	544	14.107	−64.145	−34.775	1.00	64.22	C
ATOM	4382	C	VAL	A	544	11.850	−64.895	−36.395	1.00	54.74	C
ATOM	4383	O	VAL	A	544	10.961	−64.187	−35.974	1.00	58.25	O
ATOM	4384	N	ASN	A	545	11.826	−66.112	−36.271	1.00	54.18	N
ATOM	4385	CA	ASN	A	545	10.847	−66.141	−35.414	1.00	55.71	C
ATOM	4386	CB	ASN	A	545	10.521	−68.264	−35.875	1.00	56.96	C
ATOM	4387	CB	ASN	A	545	10.240	−68.344	−37.361	1.00	60.84	C
ATOM	4388	OD1	ASN	A	545	9.243	−67.803	−37.857	1.00	60.63	O
ATOM	4389	ND2	ASN	A	545	11.128	−69.009	−38.085	1.00	56.88	N
ATOM	4390	C	ASN	A	545	11.475	−66.854	−34.048	1.00	55.79	C
ATOM	4391	O	ASN	A	545	12.704	−66.828	−33.945	1.00	57.77	O
ATOM	4392	N	THR	A	546	10.643	−66.912	−33.009	1.00	51.07	N
ATOM	4393	CA	THR	A	546	11.110	−66.808	−31.628	1.00	47.27	C
ATOM	4394	CB	THR	A	546	12.009	−65.569	−31.385	1.00	44.80	C
ATOM	4395	OG1	THR	A	546	12.421	−65.565	−30.018	1.00	49.88	O
ATOM	4396	CG2	THR	A	546	11.304	−64.272	−31.702	1.00	41.22	C
ATOM	4397	C	THR	A	546	9.982	−66.815	−30.612	1.00	47.57	C
ATOM	4398	O	THR	A	546	8.813	−67.034	−30.959	1.00	52.26	O
ATOM	4399	N	VAL	A	547	10.354	−66.591	−29.355	1.00	44.96	N
ATOM	4400	CA	VAL	A	547	9.403	−66.430	−28.266	1.00	44.34	C
ATOM	4401	CB	VAL	A	547	9.454	−67.635	−27.354	1.00	46.29	C
ATOM	4402	CG1	VAL	A	547	8.315	−67.590	−26.347	1.00	42.97	C
ATOM	4403	CG2	VAL	A	547	9.407	−68.894	−28.198	1.00	49.35	C
ATOM	4404	C	VAL	A	547	9.686	−65.191	−27.422	1.00	45.25	C
ATOM	4405	O	VAL	A	547	10.769	−65.059	−26.859	1.00	48.33	O
ATOM	4406	N	LEU	A	548	8.699	−64.298	−27.332	1.00	43.62	N
ATOM	4407	CA	LEU	A	548	8.788	−63.079	−26.532	1.00	38.43	C
ATOM	4408	CB	LEU	A	548	7.690	−62.124	−26.938	1.00	37.12	C
ATOM	4409	CG	LEU	A	548	7.549	−60.141	−26.320	1.00	35.06	C
ATOM	4410	CD1	LEU	A	548	8.633	−59.814	−26.852	1.00	33.20	C
ATOM	4411	CD2	LEU	A	548	6.161	−60.217	−26.711	1.00	31.26	C
ATOM	4412	C	LEU	A	518	8.637	−63.590	−25.075	1.00	38.09	C
ATOM	4413	O	LEU	A	548	7.696	−64.075	−24.684	1.00	41.95	O
ATOM	4414	N	HIS	A	549	9.571	−62.888	−24.273	1.00	35.37	N
ATOM	4415	CA	HIS	A	549	9.572	−63.121	−22.829	1.00	33.02	C
ATOM	4416	CB	HIS	A	549	10.858	−63.868	−22.414	1.00	34.31	C
ATOM	4417	CG	HIS	A	549	10.945	−65.263	−22.946	1.00	36.97	C
ATOM	4418	ND1	HIS	A	549	11.360	−65.548	−24.230	1.00	39.69	N
ATOM	4419	CE1	HIS	A	549	11.319	−66.854	−24.418	1.00	38.88	C
ATOM	4420	NE2	HIS	A	549	10.915	−67.427	−23.295	1.00	34.95	N
ATOM	4421	CD2	HIS	A	549	10.672	−66.455	−22.363	1.00	36.43	C
ATOM	4422	C	HIS	A	549	9.519	−61.802	−22.067	1.00	29.26	C
ATOM	4423	O	HIS	A	549	9.292	−61.285	−20.851	1.00	27.95	O
ATOM	4424	N	GLY	A	550	9.798	−60.703	−22.755	1.00	27.90	N
ATOM	4425	CA	GLY	A	550	9.808	−59.413	−22.079	1.00	29.27	C
ATOM	4426	C	GLY	A	550	10.290	−58.264	−22.917	1.00	27.71	C
ATOM	4427	O	GLY	A	550	10.519	−58.412	−24.114	1.00	30.25	O
ATOM	4428	N	PHE	A	551	10.417	−57.115	−22.271	1.00	26.66	N
ATOM	4429	CA	PHE	A	551	10.863	−55.881	−22.892	1.00	28.76	C
ATOM	4430	CB	PHE	A	551	9.692	−54.888	−23.014	1.00	29.94	C
ATOM	4431	CG	PHE	A	551	8.657	−55.342	−23.986	1.00	29.55	C
ATOM	4432	CD1	PHE	A	551	7.708	−56.283	−23.619	1.00	29.41	C
ATOM	4433	CE1	PHE	A	551	6.788	−56.755	−24.544	1.00	30.09	C
ATOM	4434	CZ	PHE	A	551	6.824	−56.309	−25.853	1.00	30.37	C
ATOM	4435	CE2	PHE	A	551	7.767	−55.372	−26.243	1.00	31.20	C
ATOM	4436	CD2	PHE	A	551	8.697	−54.909	−25.309	1.00	32.06	C
ATOM	4437	C	PHE	A	551	11.983	−55.299	−22.065	1.00	32.30	C
ATOM	4438	O	PHE	A	551	11.807	−55.035	−20.866	1.00	31.63	O
ATOM	4439	N	ALA	A	552	13.161	−55.191	−22.698	1.00	33.75	N
ATOM	4440	CA	ALA	A	552	14.257	−54.363	−22.201	1.00	30.36	C
ATOM	4441	CB	ALA	A	552	15.518	−54.610	−23.022	1.00	31.49	C
ATOM	4442	C	ALA	A	552	13.869	−52.894	−22.295	1.00	28.76	C
ATOM	4443	O	ALA	A	552	13.383	−52.449	−23.345	1.00	28.28	O
ATOM	4444	N	GLY	A	553	14.056	−52.146	−21.209	1.00	26.19	N
ATOM	4445	CA	GLY	A	553	13.997	−50.684	−21.303	1.00	28.08	C
ATOM	4146	C	GLY	A	553	15.374	−50.020	−21.132	1.00	31.88	C
ATOM	4447	O	GLY	A	553	16.289	−50.565	−20.469	1.00	31.48	O
ATOM	4448	N	TYR	A	554	15.526	−48.850	−21.748	1.00	31.52	N
ATOM	4449	CA	TYR	A	554	16.740	−48.058	−21.645	1.00	31.98	C
ATOM	4450	CB	TYR	A	554	17.653	−48.272	−22.859	1.00	30.24	C
ATOM	4451	CG	TYR	A	554	17.892	−49.720	−23.310	1.00	28.60	C
ATOM	4452	CD1	TYR	A	554	17.138	−50.288	−24.341	1.00	26.94	C
ATOM	4453	CE1	TYR	A	554	17.369	−51.587	−24.762	1.00	26.39	C
ATOM	4454	CZ	TYR	A	554	18.383	−52.335	−24.157	1.00	26.08	C
ATOM	4455	OH	TYR	A	554	18.623	−53.637	−24.569	1.00	26.89	O
ATOM	4456	CE2	TYR	A	554	19.128	−51.799	−23.134	1.00	23.81	C
ATOM	4457	CD2	TYR	A	554	18.895	−50.499	−22.729	1.00	26.36	C
ATOM	4458	C	TYR	A	554	16.284	−46.614	−21.641	1.00	34.81	C
ATOM	4459	O	TYR	A	554	15.076	−46.329	−21.724	1.00	33.36	O
ATOM	4460	N	PHE	A	555	17.228	−45.687	−21.575	1.00	34.41	N
ATOM	4461	CA	PHE	A	555	16.846	−44.288	−21.652	1.00	36.58	C
ATOM	4462	CB	PHE	A	555	16.511	−43.755	−20.252	1.00	39.29	C
ATOM	4463	CG	PHE	A	555	17.727	−43.463	−19.398	1.00	38.20	C
ATOM	4464	CD1	PHE	A	555	18.209	−44.440	−18.584	1.00	38.56	C
ATOM	4465	CE1	PHE	A	555	19.381	−44.163	−17.795	1.00	39.54	C
ATOM	4466	CZ	PHE	A	555	19.963	−42.899	−17.818	1.00	38.33	C
ATOM	4467	CE2	PHE	A	555	19.432	−41.912	−18.629	1.00	37.28	C
ATOM	4468	CD2	PHE	A	555	18.322	−42.195	−19.412	1.00	37.86	C
ATOM	4469	C	PHE	A	555	17.938	−43.425	−22.259	1.00	37.99	C
ATOM	4470	O	PHE	A	555	19.111	−43.817	−22.287	1.00	39.68	O
ATOM	4471	N	GLU	A	556	17.543	−42.226	−22.678	1.00	38.18	N
ATOM	4472	CA	GLU	A	556	18.468	−41.171	−23.065	1.00	41.35	C
ATOM	4473	CB	GLU	A	556	18.494	−40.978	−24.589	1.00	40.73	C
ATOM	4474	CG	GLU	A	556	19.267	−42.039	−25.376	1.00	43.14	C
ATOM	4475	CD	GLU	A	556	19.159	−41.846	−26.888	1.00	44.55	C
ATOM	4476	OE1	GLU	A	556	18.370	−40.982	−27.345	1.00	43.88	O
ATOM	4477	OE2	GLU	A	556	19.862	−42.561	−27.627	1.00	42.69	O
ATOM	4478	C	GLU	A	556	18.029	−39.881	−22.392	1.00	43.30	C
ATOM	4479	O	GLU	A	556	16.825	−39.679	−22.128	1.00	47.79	O
ATOM	4480	N	THR	A	557	19.000	−39.024	−22.094	1.00	39.66	N
ATOM	4481	CA	THR	A	557	18.708	−37.717	−21.527	1.00	42.85	C
ATOM	4482	CB	THR	A	557	18.714	−37.704	−19.970	1.00	43.11	C
ATOM	4483	OG1	THR	A	557	18.091	−36.494	−19.498	1.00	48.44	O
ATOM	4484	CG1	THR	A	557	20.108	−37.797	−19.398	1.00	36.20	C
ATOM	4485	C	THR	A	557	19.646	−36.636	−22.062	1.00	42.03	C
ATOM	4486	O	THR	A	557	20.843	−36.862	−22.241	1.00	40.52	O
ATOM	4487	N	VAL	A	558	19.066	−35.473	−22.327	1.00	40.06	N
ATOM	4488	CA	VAL	A	558	19.820	−34.284	−22.656	1.00	38.02	C
ATOM	4489	CB	VAL	A	558	19.055	−33.371	−23.639	1.00	36.28	C
ATOM	4490	CG1	VAL	A	558	19.762	−32.017	−23.815	1.00	34.87	C
ATOM	4491	CG2	VAL	A	558	18.872	−34.071	−24.984	1.00	32.39	C
ATOM	4492	C	VAL	A	558	20.060	−33.574	−21.343	1.00	38.11	C
ATOM	4493	O	VAL	A	558	19.129	−33.031	−20.720	1.00	38.03	O
ATOM	4494	N	LEU	A	559	21.309	−33.627	−20.913	1.00	36.93	N
ATOM	4495	CA	LEU	A	559	21.780	−32.861	−19.767	1.00	42.23	C
ATOM	4496	CB	LEU	A	559	23.203	−33.315	−19.405	1.00	41.25	C
ATOM	4497	CG	LEU	A	559	23.479	−34.203	−18.190	1.00	41.81	C
ATOM	4498	CD1	LEU	A	559	22.328	−35.140	−17.883	1.00	37.30	C
ATOM	4499	CD2	LEU	A	559	24.818	−34.949	−18.308	1.00	39.67	C
ATOM	4500	C	LEU	A	559	21.747	−31.363	−20.112	1.00	43.20	C
ATOM	4501	O	LEU	A	559	21.018	−30.588	−19.491	1.00	45.06	O
ATOM	4502	N	TYR	A	560	22.523	−30.981	−21.131	1.00	47.55	N
ATOM	4503	CA	TYR	A	560	22.526	−29.516	−21.697	1.00	46.76	C
ATOM	4504	CB	TYR	A	560	23.362	−28.555	−20.840	1.00	45.49	C
ATOM	4505	CG	TYR	A	560	23.200	−27.200	−21.237	1.00	48.95	C
ATOM	4506	CD1	TYR	A	560	21.983	−26.531	−21.041	1.00	45.72	C
ATOM	4507	CE1	TYR	A	560	21.836	−25.202	−21.409	1.00	49.54	C
ATOM	4508	CZ	TYR	A	560	22.920	−24.514	−21.984	1.00	50.74	C
ATOM	4509	OH	TYR	A	560	22.769	−23.192	−22.355	1.00	47.80	O
ATOM	4510	CE2	TYR	A	560	24.129	−23.158	−22.195	1.00	45.64	C
ATOM	4511	CD2	TYR	A	560	24.264	−26.489	−21.824	1.00	48.64	C
ATOM	4512	C	TYR	A	560	23.014	−29.588	−23.155	1.00	47.86	C
ATOM	4513	O	TYR	A	560	24.166	−29.956	−23.463	1.00	45.71	O
ATOM	4514	N	GLN	A	561	22.125	−29.163	−24.048	1.00	47.64	N
ATOM	4515	CA	GLN	A	561	22.453	−29.041	−25.469	1.00	49.14	C
ATOM	4516	CB	GLN	A	561	23.502	−27.936	−25.698	1.00	47.70	C
ATOM	4517	CG	GLN	A	561	22.873	−26.551	−25.652	1.00	47.84	C
ATOM	4518	CD	GLN	A	561	23.873	−25.403	−25.636	1.00	50.24	C
ATOM	4519	OE1	GLN	A	561	25.104	−25.592	−25.745	1.00	45.33	O
ATOM	4520	NE2	GLN	A	561	23.339	−24.188	−25.506	1.00	45.55	N
ATOM	4521	C	GLN	A	561	22.891	−30.358	−26.101	1.00	48.85	C
ATOM	4522	O	GLN	A	561	22.055	−31.222	−26.346	1.00	48.76	O
ATOM	4523	N	ASP	A	562	24.188	−30.492	−26.375	1.00	46.70	N
ATOM	4524	CA	ASP	A	562	24.725	−31.697	−27.002	1.00	45.21	C
ATOM	4525	CB	ASP	A	562	25.766	−31.365	−28.091	1.00	46.34	C
ATOM	4526	CG	ASP	A	562	27.030	−30.695	−27.538	1.00	49.44	C
ATOM	4327	OD1	ASP	A	562	26.915	−29.642	−26.859	1.00	48.63	O
ATOM	4528	OD2	ASP	A	562	28.142	−31.216	−27.805	1.00	51.94	O
ATOM	4329	C	ASP	A	562	25.327	−32.635	−25.986	1.00	43.64	C
ATOM	4530	O	ASP	A	562	25.801	−33.718	−26.332	1.00	45.33	O
ATOM	4331	N	ILE	A	563	25.322	−32.226	−24.730	1.00	42.89	N
ATOM	4532	CA	ILE	A	563	25.885	−33.079	−23.713	1.00	46.30	C
ATOM	4533	CB	ILE	A	563	26.540	−32.278	−22.575	1.00	48.26	C
ATOM	4534	CG1	ILE	A	563	27.893	−31.737	−23.043	1.00	50.44	C
ATOM	4535	CD1	ILE	A	563	27.793	−30.647	−24.077	1.00	54.09	C
ATOM	4536	CG2	ILE	A	563	26.798	−33.178	−21.366	1.00	47.82	C
ATOM	4537	C	ILE	A	563	24.804	−34.016	−23.206	1.00	45.57	C
ATOM	4538	O	ILE	A	563	23.784	−33.565	−22.670	1.00	46.14	O
ATOM	4539	N	THR	A	564	25.033	−35.315	−23.401	1.00	43.66	N
ATOM	4540	CA	THR	A	564	24.024	−36.329	−23.103	1.00	43.08	C
ATOM	4541	CB	THR	A	564	23.422	−36.952	−24.379	1.00	43.34	C
ATOM	4542	OG1	THR	A	564	24.461	−37.592	−25.129	1.00	41.15	O
ATOM	4543	CG2	THR	A	564	22.673	−35.900	−25.227	1.00	38.71	C
ATOM	4544	C	THR	A	564	24.544	−37.483	−22.277	1.00	42.38	C
ATOM	4545	O	THR	A	564	25.754	−37.686	−22.111	1.00	44.36	O
ATOM	4546	N	LEU	A	565	23.594	−33.228	−21.743	1.00	40.72	N
ATOM	4547	CA	LEU	A	565	23.860	−39.530	−21.147	1.00	38.68	C
ATOM	4548	CB	LEU	A	565	23.611	−39.493	−19.642	1.00	39.17	C
ATOM	4549	CG	LEU	A	565	24.482	−38.595	−18.751	1.00	40.74	C
ATOM	4550	CD1	LEU	A	565	23.953	−38.673	−17.330	1.00	38.87	C
ATOM	4551	CD2	LEU	A	565	25.972	−38.966	−18.798	1.00	38.06	C
ATOM	4552	C	LEU	A	565	22.910	−40.528	−21.795	1.00	36.91	C
ATOM	4553	O	LEU	A	565	21.722	−40.202	−22.072	1.00	35.07	O
ATOM	4554	N	SER	A	566	23.420	−41.740	−22.013	1.00	34.32	N
ATOM	4555	CA	SER	A	566	22.630	−42.784	−22.651	1.00	32.79	C
ATOM	4556	CB	SER	A	566	22.659	−42.596	−24.160	1.00	30.65	C
ATOM	4557	OG	SER	A	566	22.177	−43.742	−24.802	1.00	35.55	O
ATOM	4558	C	SER	A	566	23.045	−44.200	−22.250	1.00	34.88	C
ATOM	4559	O	SER	A	566	24.243	−44.484	−22.091	1.00	34.26	O
ATOM	4560	N	ILE	A	567	22.042	−45.060	−22.041	1.00	34.36	N
ATOM	4561	CA	ILE	A	567	22.251	−46.513	−21.941	1.00	34.98	C
ATOM	4562	CB	ILE	A	567	21.794	−47.138	−20.604	1.00	36.17	C
ATOM	4563	CG1	ILE	A	567	20.283	−46.955	−20.378	1.00	35.09	C
ATOM	4564	CD1	ILE	A	567	19.772	−47.857	−19.272	1.00	34.93	C
ATOM	4565	CG2	ILE	A	567	22.646	−46.642	−19.447	1.00	34.25	C
ATOM	4566	C	ILE	A	567	21.542	−47.274	−23.049	1.00	35.98	C
ATOM	4567	O	ILE	A	567	21.458	−48.497	−23.010	1.00	37.22	O
ATOM	4568	N	ARG	A	568	21.026	−46.553	−24.035	1.00	37.18	N
ATOM	4569	CA	ARG	A	568	20.475	−47.203	−25.200	1.00	38.53	C
ATOM	4570	CB	ARG	A	568	19.726	−46.180	−26.013	1.00	35.61	C
ATOM	4571	CG	ARG	A	568	19.430	−46.624	−27.421	1.00	37.27	C
ATOM	4572	CD	ARG	A	568	18.711	−45.506	−28.140	1.00	41.12	C
ATOM	4573	NE	ARG	A	568	18.468	−45.805	−29.544	1.00	45.59	N
ATOM	4574	CZ	ARG	A	568	18.447	−44.873	−30.496	1.00	49.11	C
ATOM	4575	NH1	ARG	A	568	18.671	−43.585	−30.198	1.00	44.43	N
ATOM	4576	NH2	ARG	A	568	18.218	−45.229	−31.752	1.00	46.98	N
ATOM	4577	C	ARG	A	568	21.651	−47.731	−25.995	1.00	39.69	C
ATOM	4578	O	ARG	A	568	22.467	−46.946	−26.428	1.00	43.37	O
ATOM	4579	N	PRO	A	569	21.726	−49.054	−26.218	1.00	43.58	N
ATOM	4580	CA	PRO	A	569	22.932	−49.639	−26.828	1.00	42.10	C
ATOM	4581	CB	PRO	A	569	22.495	−51.072	−27.182	1.00	41.35	C
ATOM	4582	CG	PRO	A	569	21.363	−51.367	−26.233	1.00	42.01	C
ATOM	4583	CD	PRO	A	569	20.636	−50.052	−26.098	1.00	44.34	C
ATOM	4584	C	PRO	A	569	23.465	−48.886	−28.059	1.00	43.79	C
ATOM	4585	O	PRO	A	569	24.651	−48.657	−28.125	1.00	42.51	O
ATOM	4586	N	GLU	A	570	22.612	−48.458	−28.993	1.00	46.30	N
ATOM	4587	CA	GLU	A	570	23.108	−47.773	−30.208	1.00	45.11	C
ATOM	4588	CB	GLU	A	570	21.976	−47.484	−31.210	1.00	46.56	C
ATOM	4589	CG	GLU	A	570	21.142	−48.682	−31.657	1.00	53.42	C
ATOM	4590	CD	GLU	A	570	19.919	−48.917	−30.738	1.00	59.56	C
ATOM	4591	OE1	GLU	A	570	20.030	−49.830	−29.889	1.00	58.49	O
ATOM	4592	OE2	GLU	A	570	18.941	−48.167	−30.834	1.00	64.19	O
ATOM	4593	C	GLU	A	570	23.904	−46.469	−29.946	1.00	44.45	C
ATOM	4594	O	GLU	A	570	24.590	−45.970	−30.835	1.00	45.25	O
ATOM	4595	N	THR	A	571	23.792	−45.906	−28.746	1.00	43.65	N
ATOM	4596	CA	THR	A	571	24.332	−44.578	−28.433	1.00	37.49	C
ATOM	4597	CB	THR	A	571	23.268	−43.460	−28.583	1.00	39.97	C
ATOM	4598	OG1	THR	A	571	22.289	−43.611	−27.553	1.00	40.55	O
ATOM	4599	CG2	THR	A	571	22.555	−43.486	−29.941	1.00	39.05	C
ATOM	4600	C	THR	A	571	24.790	−44.575	−26.983	1.00	35.77	C
ATOM	4601	O	THR	A	571	24.821	−43.524	−26.346	1.00	34.89	O
ATOM	4602	N	HIS	A	572	25.113	−45.758	−26.458	1.00	39.75	N
ATOM	4603	CA	HIS	A	572	25.543	−45.926	−25.060	1.00	45.87	C
ATOM	4604	CB	HIS	A	572	25.985	−47.369	−24.780	1.00	45.83	C
ATOM	4605	CG	HIS	A	572	25.833	−47.781	−23.343	1.00	50.03	C
ATOM	4606	ND1	HIS	A	572	26.553	−47.202	−22.318	1.00	48.55	N
ATOM	4607	CE1	HIS	A	572	26.208	−47.755	−23.169	1.00	47.09	C
ATOM	4608	NE2	HIS	A	572	25.288	−48.672	−21.407	1.00	49.45	N
ATOM	4609	CD2	HIS	A	572	25.031	−48.707	−22.758	1.00	50.13	C
ATOM	4610	C	HIS	A	572	26.707	−44.975	−24.778	1.00	45.89	C
ATOM	4611	O	HIS	A	572	27.553	−44.795	−25.646	1.00	45.59	O
ATOM	4612	N	SER	A	573	26.715	−44.343	−23.599	1.00	45.41	N
ATOM	4613	CA	SER	A	573	27.828	−43.498	−23.168	1.00	44.45	C
ATOM	4614	CB	SER	A	573	27.446	−42.639	−21.969	1.00	41.77	C
ATOM	4615	OG	SER	A	573	26.302	−41.847	−22.265	1.00	43.73	O
ATOM	4616	C	SER	A	573	28.973	−44.421	−22.812	1.00	43.40	C
ATOM	4617	O	SER	A	573	28.800	−45.340	−22.016	1.00	43.42	O
ATOM	4618	N	PRO	A	574	30.144	−44.218	−23.435	1.00	52.03	N
ATOM	4619	CA	PRO	A	574	31.212	−45.204	−23.198	1.00	54.00	C
ATOM	4620	CB	PRO	A	574	32.291	−44.782	−24.189	1.00	49.99	C
ATOM	4621	CG	PRO	A	574	31.494	−44.164	−25.312	1.00	53.46	C
ATOM	4622	CD	PRO	A	574	30.451	−43.352	−24.588	1.00	49.96	C
ATOM	4623	C	PRO	A	574	31.720	−45.161	−21.762	1.00	53.25	C
ATOM	4624	O	PRO	A	574	31.881	−44.077	−21.200	1.00	57.19	O
ATOM	4625	N	GLY	A	575	31.914	−46.333	−21.164	1.00	48.34	N
ATOM	4626	CA	GLY	A	575	32.419	−46.418	−19.798	1.00	47.94	C
ATOM	4627	C	GLY	A	575	31.420	−46.208	−18.667	1.00	48.79	C
ATOM	4628	O	GLY	A	575	31.728	−46.505	−17.514	1.00	49.08	O
ATOM	4629	N	MET	A	576	30.231	−45.692	−18.975	1.00	46.94	N
ATOM	4630	CA	MET	A	576	29.236	−45.422	−17.943	1.00	43.02	C
ATOM	4631	CB	MET	A	576	28.172	−44.469	−18.455	1.00	39.85	C
ATOM	4632	CG	MET	A	576	27.336	−43.894	−17.342	1.00	39.12	C
ATOM	4633	SD	MET	A	576	26.052	−42.827	−17.997	1.00	42.80	S
ATOM	4634	CE	MET	A	576	29.177	−43.979	−19.043	1.00	41.08	C
ATOM	4635	C	MET	A	576	28.576	−46.702	−17.468	1.00	43.38	C
ATOM	4636	O	MET	A	576	27.873	−47.358	−18.227	1.00	49.91	O
ATOM	4637	N	PHE	A	577	28.803	−47.048	−16.210	1.00	43.02	N
ATOM	4638	CA	PHE	A	577	28.258	−48.273	−15.637	1.00	42.04	C
ATOM	4639	CB	PHE	A	577	29.374	−49.090	−14.959	1.00	45.88	C
ATOM	4640	CG	PHE	A	577	30.106	−48.356	−13.858	1.00	51.74	C
ATOM	4641	CD1	PHE	A	577	29.572	−48.285	−12.564	1.00	53.16	C
ATOM	4642	CE1	PHE	A	577	30.258	−47.622	−11.545	1.00	54.32	C
ATOM	4643	CZ	PHE	A	577	31.487	−47.022	−11.809	1.00	48.76	C
ATOM	4644	CE2	PHE	A	577	32.029	−47.085	−13.090	1.00	48.17	C
ATOM	4645	CD2	PHE	A	577	31.347	−47.747	−14.104	1.00	49.18	C
ATOM	4646	C	PHE	A	577	27.103	−48.039	−14.663	1.00	37.84	C
ATOM	4647	O	PHE	A	577	26.583	−48.977	−14.097	1.00	41.49	O
ATOM	4648	N	SER	A	578	26.705	−46.787	−14.490	1.00	36.56	N
ATOM	4649	CA	SER	A	578	25.767	−46.385	−13.444	1.00	34.99	C
ATOM	4650	CB	SER	A	578	25.731	−44.870	−13.340	1.00	33.78	C
ATOM	4651	OG	SER	A	578	26.697	−44.407	−12.414	1.00	38.25	O
ATOM	4652	C	SER	A	578	24.336	−46.947	−13.581	1.00	35.47	C
ATOM	4653	O	SER	A	578	23.668	−47.230	−12.574	1.00	35.32	O
ATOM	4654	N	TRP	A	579	23.892	−47.221	−14.809	1.00	33.06	N
ATOM	4655	CA	TRP	A	579	22.605	−47.849	−15.042	1.00	36.72	C
ATOM	4656	CB	TRP	A	579	21.627	−46.908	−15.750	1.00	35.28	C
ATOM	4657	CG	TRP	A	579	21.341	−45.657	−15.009	1.00	37.41	C
ATOM	4658	CD1	TRP	A	579	20.411	−45.488	−14.037	1.00	40.14	C
ATOM	4659	NE1	TRP	A	579	20.407	−44.383	−13.590	1.00	40.42	N
ATOM	4660	CE2	TRP	A	579	21.361	−43.484	−14.277	1.00	39.25	C
ATOM	4661	CD2	TRP	A	579	21.971	−44.380	−15.182	1.00	38.00	C
ATOM	4662	CE3	TRP	A	579	22.992	−43.907	−15.999	1.00	40.06	C
ATOM	4663	CZ3	TRP	A	579	23.359	−42.565	−15.898	1.00	39.21	C
ATOM	4664	CH2	TRP	A	579	22.729	−41.706	−14.999	1.00	38.40	C
ATOM	4665	CZ2	TRP	A	579	21.736	−42.144	−14.178	1.00	39.15	C
ATOM	4666	C	TRP	A	579	22.730	−49.110	−15.863	1.00	35.78	C
ATOM	4667	O	TRP	A	579	23.273	−49.097	−16.954	1.00	37.63	O
ATOM	4668	N	PHE	A	580	22.196	−50.202	−15.329	1.00	37.09	N
ATOM	4669	CA	PHE	A	580	21.918	−51.374	−16.131	1.00	32.82	C
ATOM	4670	CB	PHE	A	580	21.878	−52.613	−15.245	1.00	33.81	C
ATOM	4671	CG	PHE	A	580	23.210	−53.602	−14.671	1.00	32.62	C
ATOM	4672	CD1	PHE	A	580	24.389	−52.710	−15.346	1.00	33.84	C
ATOM	4673	CE1	PHE	A	580	25.619	−53.093	−14.820	1.00	35.72	C
ATOM	4674	CZ	PHE	A	580	25.681	−53.779	−13.616	1.00	34.17	C
ATOM	4675	CE2	PHE	A	580	24.501	−54.101	−12.950	1.00	36.40	C
ATOM	4676	CD2	PHE	A	580	23.278	−53.723	−13.485	1.00	32.25	C
ATOM	4677	C	PHE	A	580	20.565	−51.168	−16.821	1.00	31.25	C
ATOM	4678	O	PHE	A	580	19.775	−50.316	−16.394	1.00	28.16	O
ATOM	4679	N	PRO	A	581	20.297	−51.947	−17.890	1.00	31.63	N
ATOM	4680	CA	PRO	A	581	18.976	−52.013	−18.493	1.00	29.14	C
ATOM	4681	CB	PRO	A	581	19.138	−53.093	−19.560	1.00	30.28	C
ATOM	4682	CG	PRO	A	581	20.581	−53.083	−19.930	1.00	32.23	C
ATOM	4683	CD	PRO	A	581	21.282	−52.768	−18.632	1.00	31.21	C
ATOM	4684	C	PRO	A	581	17.879	−52.437	−17.497	1.00	31.91	C
ATOM	4685	O	PRO	A	581	18.171	−52.992	−16.417	1.00	30.17	O
ATOM	4686	N	ILE	A	582	16.625	−52.166	−17.863	1.00	30.04	N
ATOM	4687	CA	ILE	A	582	15.490	−52.601	−17.073	1.00	30.27	C
ATOM	4688	CB	ILE	A	582	14.559	−51.408	−16.716	1.00	29.87	C
ATOM	4689	CG1	ILE	A	582	13.934	−51.621	−15.335	1.00	31.76	C
ATOM	4690	CD1	ILE	A	582	13.257	−50.423	−14.714	1.00	30.06	C
ATOM	4691	CG2	ILE	A	582	13.458	−51.280	−17.739	1.00	30.30	C
ATOM	4692	C	ILE	A	582	14.701	−53.711	−17.807	1.00	30.18	C
ATOM	4693	O	ILE	A	582	14.640	−53.746	−19.032	1.00	28.98	O
ATOM	4694	N	LEU	A	583	14.078	−54.613	−17.059	1.00	30.84	N
ATOM	4695	CA	LEU	A	583	13.297	−55.654	−17.703	1.00	31.06	C
ATOM	4696	CB	LEU	A	583	13.865	−57.046	−17.408	1.00	32.07	C
ATOM	4697	CG	LEU	A	583	12.971	−58.248	−17.763	1.00	35.14	C
ATOM	4698	CD1	LEU	A	583	12.582	−58.265	−19.236	1.00	32.31	C
ATOM	4699	CD2	LEU	A	583	13.741	−59.503	−17.405	1.00	34.76	C
ATOM	4700	C	LEU	A	583	11.826	−55.584	−17.321	1.00	28.77	C
ATOM	4701	O	LEU	A	583	11.439	−55.627	−16.153	1.00	25.49	O
ATOM	4702	N	PHE	A	584	11.005	−55.486	−18.335	1.00	28.79	N
ATOM	4703	CA	PHE	A	584	9.576	−55.681	−18.150	1.00	27.90	C
ATOM	4704	CB	PHE	A	584	8.826	−54.615	−18.947	1.00	29.29	C
ATOM	4705	CG	PHE	A	584	8.821	−53.273	−18.292	1.00	31.25	C
ATOM	4706	CD1	PHE	A	584	7.904	−52.986	−17.263	1.00	35.48	C
ATOM	4707	CE1	PHE	A	584	7.880	−51.722	−16.658	1.00	36.00	C
ATOM	4708	CZ	PHE	A	584	8.777	−50.746	−17.082	1.00	33.80	C
ATOM	4709	CE2	PHE	A	584	9.681	−51.019	−18.112	1.00	31.95	C
ATOM	4710	CD2	PHE	A	584	9.685	−52.273	−18.719	1.00	31.91	C
ATOM	4711	C	PHE	A	584	9.246	−57.090	−18.652	1.00	26.33	C
ATOM	4712	O	PHE	A	584	9.364	−57.352	−19.840	1.00	22.93	O
ATOM	4713	N	PRO	A	585	8.910	−58.014	−17.742	1.00	27.86	N
ATOM	4714	CA	PRO	A	585	8.477	−59.363	−18.076	1.00	30.72	C
ATOM	4715	CB	PRO	A	585	8.483	−60.097	−16.730	1.00	30.16	C
ATOM	4716	CG	PRO	A	585	8.994	−39.128	−15.708	1.00	31.56	C
ATOM	4717	CD	PRO	A	585	8.839	−57.763	−16.294	1.00	32.21	C
ATOM	4718	C	PRO	A	585	7.052	−59.362	−18.604	1.00	33.64	C
ATOM	4719	O	PRO	A	585	6.357	−58.353	−18.454	1.00	37.92	O
ATOM	4720	N	ILE	A	586	6.644	−60.472	−19.233	1.00	33.99	N
ATOM	4721	CA	ILE	A	586	5.219	−60.801	−19.444	1.00	35.82	C
ATOM	4722	CB	ILE	A	586	4.795	−60.654	−20.939	1.00	32.51	C
ATOM	4723	CG1	ILE	A	586	5.635	−61.549	−21.842	1.00	32.89	C
ATOM	4724	CD1	ILE	A	586	4.960	−61.882	−23.162	1.00	30.42	C
ATOM	4725	CG2	ILE	A	586	4.903	−59.204	−21.411	1.00	28.88	C
ATOM	4726	C	ILE	A	586	4.867	−62.203	−18.861	1.00	37.85	C
ATOM	4727	O	ILE	A	586	5.680	−63.123	−18.925	1.00	42.70	O
ATOM	4728	N	LYS	A	587	3.668	−62.356	−18.294	1.00	39.46	N
ATOM	4729	CA	LYS	A	587	3.228	−63.604	−17.638	1.00	38.62	C
ATOM	4730	CB	LYS	A	587	1.758	−63.535	−17.233	1.00	38.40	C
ATOM	4731	CG	LYS	A	587	1.530	−63.021	−15.834	1.00	42.66	C
ATOM	4732	CD	LYS	A	587	0.124	−62.459	−15.678	1.00	44.02	C
ATOM	4733	CE	LYS	A	587	−0.090	−61.901	−14.273	1.00	47.08	C
ATOM	4734	NZ	LYS	A	587	−1.455	−62.210	−13.729	1.00	52.67	N
ATOM	4735	C	LYS	A	587	3.403	−64.858	−18.475	1.00	41.64	C
ATOM	4736	O	LYS	A	587	3.846	−65.888	−17.950	1.00	43.44	O
ATOM	4737	N	GLN	A	588	3.042	−64.773	−19.757	1.00	37.57	N
ATOM	4738	CA	GLN	A	588	3.110	−65.905	−20.647	1.00	35.17	C
ATOM	4739	CB	GLN	A	588	1.703	−66.343	−21.086	1.00	35.67	C
ATOM	4740	CG	GLN	A	588	0.975	−67.139	−20.010	1.00	37.57	C
ATOM	4741	CD	GLN	A	588	1.569	−68.538	−19.817	1.00	40.46	C
ATOM	4742	OE1	GLN	A	588	1.641	−69.349	−20.762	1.00	37.67	O
ATOM	4743	NE2	GLN	A	588	1.983	−68.833	−18.590	1.00	40.56	N
ATOM	4744	C	GLN	A	588	3.959	−65.592	−21.852	1.00	36.10	C
ATOM	4745	O	GLN	A	588	3.768	−64.579	−22.494	1.00	37.94	O
ATOM	4746	N	PRO	A	589	4.930	−66.459	−22.154	1.00	37.77	N
ATOM	4747	CA	PRO	A	589	5.727	−66.401	−23.375	1.00	34.97	C
ATOM	4748	CB	PRO	A	589	6.367	−67.778	−23.409	1.00	36.69	C
ATOM	4749	CG	PRO	A	589	6.431	−68.211	−21.984	1.00	35.55	C
ATOM	4750	CD	PRO	A	589	5.214	−67.661	−21.352	1.00	38.03	C
ATOM	4751	C	PRO	A	589	4.772	−66.310	−24.560	1.00	36.58	C
ATOM	4752	O	PRO	A	589	3.713	−66.942	−24.537	1.00	34.02	O
ATOM	4753	N	ILE	A	590	5.127	−65.557	−25.587	1.00	36.10	N
ATOM	4754	CA	ILE	A	590	4.288	−65.493	−26.768	1.00	36.21	C
ATOM	4755	CB	ILE	A	590	3.700	−64.089	−27.008	1.00	35.72	C
ATOM	4756	CG1	ILE	A	590	2.765	−63.648	−25.881	1.00	35.44	C
ATOM	4757	CD1	ILE	A	590	2.426	−62.163	−25.949	1.00	34.24	C
ATOM	4758	CG2	ILE	A	590	2.975	−64.046	−28.350	1.00	36.86	C
ATOM	4759	C	ILE	A	590	5.140	−65.809	−27.976	1.00	38.80	C
ATOM	4760	O	ILE	A	590	6.205	−65.210	−28.159	1.00	40.26	O
ATOM	4761	N	THR	A	591	4.647	−66.722	−28.813	1.00	40.29	N
ATOM	4762	CA	THR	A	591	5.340	−67.126	−30.033	1.00	40.21	C
ATOM	4763	CB	THR	A	591	4.791	−68.465	−30.551	1.00	41.07	C
ATOM	4764	OG1	THR	A	591	5.168	−69.512	−29.645	1.00	39.01	O
ATOM	4765	CG2	THR	A	591	5.310	−68.768	−31.984	1.00	38.32	C
ATOM	4766	C	THR	A	591	5.157	−66.080	−31.108	1.00	42.39	C
ATOM	4767	O	THR	A	591	4.026	−65.699	−31.428	1.00	43.38	O
ATOM	4768	N	VAL	A	592	6.269	−65.613	−31.661	1.00	40.06	N
ATOM	4769	CA	VAL	A	592	6.223	−64.683	−32.773	1.00	37.48	C
ATOM	4770	CB	VAL	A	592	6.943	−63.366	−32.424	1.00	34.09	C
ATOM	4771	CG1	VAL	A	592	6.916	−62.349	−33.577	1.00	32.38	C
ATOM	4772	CG2	VAL	A	592	6.368	−62.753	−31.166	1.00	31.00	C
ATOM	4773	C	VAL	A	592	6.879	−65.365	−33.970	1.00	46.22	C
ATOM	4774	O	VAL	A	592	7.879	−66.074	−33.818	1.00	55.51	O
ATOM	4775	N	ARG	A	593	6.306	−65.160	−35.152	1.00	50.97	N
ATOM	4776	CA	ARG	A	593	6.851	−65.680	−36.401	1.00	52.82	C
ATOM	4777	CB	ARG	A	593	5.754	−66.298	−37.257	1.00	52.58	C
ATOM	4778	CG	ARG	A	593	5.257	−67.653	−36.789	1.00	61.00	C
ATOM	4779	CD	ARG	A	593	4.171	−68.226	−37.742	1.00	73.00	C
ATOM	4780	NE	ARG	A	593	3.336	−66.990	−38.161	1.00	83.14	N
ATOM	4781	CZ	ARG	A	593	2.444	−67.006	−39.151	1.00	86.90	C
ATOM	4782	NH1	ARG	A	593	2.227	−68.115	−39.866	1.00	88.00	N
ATOM	4783	NH2	ARG	A	593	1.765	−65.894	−39.427	1.00	85.25	N
ATOM	4784	C	ARG	A	593	7.533	−64.601	−37.225	1.00	54.26	C
ATOM	4785	O	ARG	A	593	7.146	−63.423	−37.206	1.00	54.61	O
ATOM	4786	N	GLU	A	594	8.531	−65.029	−37.984	1.00	49.91	N
ATOM	4787	CA	GLU	A	594	9.227	−64.154	−38.884	1.00	51.62	C
ATOM	4788	CB	GLU	A	594	10.177	−64.969	−39.754	1.00	60.23	C
ATOM	4789	CG	GLU	A	594	10.954	−64.131	−40.756	1.00	73.65	C
ATOM	4790	CD	GLU	A	594	10.850	−64.669	−42.171	1.00	83.56	C
ATOM	4791	OE1	GLU	A	594	10.185	−65.719	−42.371	1.00	87.61	O
ATOM	4792	OE2	GLU	A	594	11.429	−64.032	−43.080	1.00	81.54	O
ATOM	4793	C	GLU	A	594	8.229	−63.408	−39.743	1.00	49.64	C
ATOM	4794	O	GLU	A	594	7.284	−64.000	−40.255	1.00	51.92	O
ATOM	4795	N	GLY	A	595	8.441	−62.107	−39.892	1.00	48.83	N
ATOM	4796	CA	GLY	A	595	7.547	−61.252	−40.680	1.00	49.47	C
ATOM	4797	C	GLY	A	595	6.475	−60.543	−39.859	1.00	48.86	C
ATOM	4798	O	GLY	A	595	5.949	−59.518	−40.286	1.00	47.80	O
ATOM	4799	N	GLN	A	596	6.161	−61.081	−38.678	1.00	45.91	N
ATOM	4800	CA	GLN	A	596	5.164	−60.484	−37.794	1.00	44.36	C
ATOM	4801	CB	GLN	A	596	4.672	−61.518	−36.797	1.00	44.70	C
ATOM	4802	CG	GLN	A	596	3.810	−62.589	−37.446	1.00	42.00	C
ATOM	4803	CD	GLN	A	596	3.225	−63.553	−36.447	1.00	43.69	C
ATOM	4804	OE1	GLN	A	596	3.842	−63.873	−35.422	1.00	44.56	O
ATOM	4805	NE2	GLN	A	596	2.014	−64.016	−36.726	1.00	43.80	N
ATOM	4806	C	GLN	A	596	5.596	−59.202	−37.066	1.00	44.96	C
ATOM	4807	O	GLN	A	596	6.791	−58.907	−36.916	1.00	44.21	O
ATOM	4808	N	THR	A	597	4.601	−58.420	−36.656	1.00	42.62	N
ATOM	4809	CA	THR	A	597	4.834	−57.256	−35.817	1.00	44.65	C
ATOM	4810	CB	THR	A	597	4.023	−56.048	−36.305	1.00	43.57	C
ATOM	4811	OG1	THR	A	597	4.453	−55.712	−37.615	1.00	42.79	O
ATOM	4812	CG2	THR	A	597	4.262	−54.842	−35.441	1.00	45.47	C
ATOM	4813	C	THR	A	597	4.470	−57.592	−34.368	1.00	44.82	C
ATOM	4814	O	THR	A	597	3.432	−58.210	−34.103	1.00	48.73	O
ATOM	4815	N	ILE	A	598	5.345	−57.233	−33.438	1.00	42.27	N
ATOM	4816	CA	ILE	A	598	4.970	−57.261	−32.033	1.00	40.02	C
ATOM	4817	CB	ILE	A	598	6.138	−57.505	−31.100	1.00	38.63	C
ATOM	4818	CG1	ILE	A	598	6.586	−58.963	−31.187	1.00	40.93	C
ATOM	4819	CD1	ILE	A	598	8.044	−59.167	−30.812	1.00	39.40	C
ATOM	4820	CG2	ILE	A	598	5.731	−57.154	−29.682	1.00	38.83	C
ATOM	4821	C	ILE	A	598	4.444	−55.889	−31.724	1.00	38.22	C
ATOM	4822	O	ILE	A	598	5.150	−54.905	−31.958	1.00	35.75	O
ATOM	4823	N	CYS	A	599	3.197	−55.829	−31.236	1.00	35.61	N
ATOM	4824	CA	CYS	A	599	2.625	−54.585	−30.753	1.00	31.06	C
ATOM	4825	CB	CYS	A	599	1.241	−54.334	−31.335	1.00	35.89	C
ATOM	4826	SG	CYS	A	599	0.636	−52.683	−30.916	1.00	41.08	S
ATOM	4827	C	CYS	A	599	2.538	−54.637	−29.249	1.00	30.23	C
ATOM	4828	O	CYS	A	599	2.042	−55.611	−28.679	1.00	29.81	O
ATOM	4829	N	VAL	A	600	3.057	−53.601	−28.598	1.00	28.90	N
ATOM	4830	CA	VAL	A	600	2.987	−53.498	−27.156	1.00	27.20	C
ATOM	4831	CB	VAL	A	600	4.373	−53.606	−26.510	1.00	27.37	C
ATOM	4832	CG1	VAL	A	600	5.113	−52.285	−26.666	1.00	26.91	C
ATOM	4833	CG2	VAL	A	600	4.227	−53.913	−25.027	1.00	29.09	C
ATOM	4834	C	VAL	A	600	2.403	−52.131	−26.793	1.00	27.09	C
ATOM	4835	O	VAL	A	600	2.377	−51.208	−27.603	1.00	26.91	O
ATOM	4836	N	ARG	A	601	1.954	−51.995	−25.558	1.00	28.21	N
ATOM	4837	CA	ARG	A	601	1.301	−50.774	−25.134	1.00	29.32	C
ATOM	4838	CB	ARG	A	601	−0.217	−50.962	−25.180	1.00	30.55	C
ATOM	4839	CG	ARG	A	601	−0.631	−51.459	−26.566	1.00	34.08	C
ATOM	4840	CD	ARG	A	601	−1.802	−50.742	−27.198	1.00	37.18	C
ATOM	4841	NE	ARG	A	601	−2.250	−51.520	−28.350	1.00	40.32	N
ATOM	4842	CE	ARG	A	601	−3.126	−51.098	−29.250	1.00	40.09	C
ATOM	4843	NH1	ARG	A	601	−3.687	−49.908	−29.142	1.00	38.52	N
ATOM	4844	NH2	ARG	A	601	−3.473	−51.886	−30.245	1.00	44.37	N
ATOM	4845	C	ARG	A	601	1.749	−50.553	−23.751	1.00	28.44	C
ATOM	4846	O	ARG	A	601	1.690	−51.472	−22.939	1.00	31.36	O
ATOM	4847	N	PHE	A	602	2.232	−49.351	−23.477	1.00	27.22	N
ATOM	4848	CA	PHE	A	602	2.656	−49.005	−22.140	1.00	27.82	C
ATOM	4849	CB	PHE	A	602	4.178	−48.687	−22.104	1.00	29.30	C
ATOM	4850	CG	PHE	A	602	5.019	−49.869	−21.716	1.00	29.85	C
ATOM	4851	CD1	PHE	A	602	5.171	−50.939	−22.584	1.00	30.20	C
ATOM	4852	CE1	PHE	A	602	5.934	−52.038	−22.209	1.00	31.47	C
ATOM	4853	CZ	PHE	A	602	6.530	−52.076	−20.958	1.00	29.86	C
ATOM	4854	CE2	PHE	A	602	6.386	−51.016	−20.086	1.00	28.02	C
ATOM	4855	CD2	PHE	A	602	5.631	−49.973	−20.470	1.00	30.02	C
ATOM	4856	C	PHE	A	602	1.890	−47.823	−21.638	1.00	28.17	C
ATOM	4857	O	PHE	A	602	1.708	−46.852	−22.372	1.00	31.12	O
ATOM	4858	N	TRP	A	603	1.493	−47.880	−20.372	1.00	28.08	N
ATOM	4859	CA	TRP	A	603	0.920	−46.723	−19.712	1.00	29.76	C
ATOM	4860	CB	TRP	A	603	−0.498	−46.999	−19.209	1.00	29.27	C
ATOM	4861	CG	TRP	A	603	−1.522	−47.381	−20.199	1.00	29.41	C
ATOM	4862	CD1	TRP	A	603	−2.525	−46.592	−20.666	1.00	34.06	C
ATOM	4863	NE1	TRP	A	603	−3.358	−47.302	−21.505	1.00	32.68	N
ATOM	4864	CE2	TRP	A	603	−2.901	−48.589	−21.592	1.00	32.38	C
ATOM	4865	CD2	TRP	A	603	−1.745	−48.684	−20.767	1.00	33.00	C
ATOM	4866	CE3	TRP	A	603	−1.076	−49.919	−20.679	1.00	30.10	C
ATOM	4867	CZ3	TRP	A	603	−1.570	−50.997	−21.402	1.00	30.19	C
ATOM	4868	CE2	TRP	A	603	−2.726	−50.865	−22.212	1.00	31.82	C
ATOM	4869	CZ2	TRP	A	603	−3.383	−49.669	−22.335	1.00	30.03	C
ATOM	4870	C	TRP	A	603	1.740	−46.301	−18.520	1.00	30.92	C
ATOM	4871	O	TRP	A	603	2.204	−47.137	−17.738	1.00	34.13	O
ATOM	4872	N	ARG	A	604	1.887	−44.994	−18.334	1.00	30.95	N
ATOM	4873	CA	ARG	A	604	2.431	−44.516	−17.059	1.00	31.62	C
ATOM	4874	CB	ARG	A	604	3.499	−43.442	−17.277	1.00	29.97	C
ATOM	4875	CG	ARG	A	604	4.171	−42.973	−16.009	1.00	30.02	C
ATOM	4876	CD	ARG	A	604	5.158	−41.369	−16.367	1.00	32.29	C
ATOM	4877	NE	ARG	A	604	6.188	−41.571	−15.368	1.00	32.23	N
ATOM	4878	CZ	ARG	A	604	6.108	−40.340	−14.325	1.00	32.29	C
ATOM	4879	NH1	ARG	A	604	5.031	−40.117	−14.123	1.00	29.49	N
ATOM	4880	NH2	ARG	A	604	7.125	−40.735	−13.473	1.00	30.96	N
ATOM	4881	C	ARG	A	604	1.251	−43.929	−16.316	1.00	28.77	C
ATOM	4882	O	ARG	A	604	0.625	−43.057	−16.840	1.00	27.90	O
ATOM	4883	N	CYS	A	605	1.041	−44.365	−15.079	1.00	29.39	N
ATOM	4884	CA	CYS	A	605	−0.139	−44.095	−14.280	1.00	32.34	C
ATOM	4885	CB	CYS	A	605	−0.890	−45.407	−14.020	1.00	31.30	C
ATOM	4886	SG	CYS	A	605	−1.411	−46.261	−15.524	1.00	39.03	S
ATOM	4887	C	CYS	A	605	0.201	−43.464	−12.936	1.00	34.02	C
ATOM	4888	O	CYS	A	605	1.351	−43.683	−12.447	1.00	30.58	O
ATOM	4889	N	SER	A	606	−0.800	−42.809	−12.327	1.00	32.64	N
ATOM	4890	CA	SER	A	606	−0.583	−42.176	−11.032	1.00	35.70	C
ATOM	4891	CB	SER	A	606	0.276	−40.918	−11.165	1.00	33.50	C
ATOM	4892	OG	SER	A	606	−0.252	−40.063	−12.130	1.00	33.87	O
ATOM	4893	C	SER	A	606	−1.774	−41.840	−10.159	1.00	39.90	C
ATOM	4894	O	SER	A	606	−2.903	−41.708	−10.623	1.00	40.91	O
ATOM	4895	N	ASN	A	607	−1.439	−41.728	−8.874	1.00	41.51	N
ATOM	4896	CA	ASN	A	607	−2.245	−41.283	−7.762	1.00	41.72	C
ATOM	4897	CB	ASN	A	607	−2.115	−42.293	−6.606	1.00	41.12	C
ATOM	4898	CG	ASN	A	607	−3.228	−43.282	−6.590	1.00	45.65	C
ATOM	4899	OD1	ASN	A	607	−4.248	−43.052	−7.219	1.00	54.04	O
ATOM	4900	ND2	ASN	A	607	−3.052	−44.891	−5.886	1.00	45.49	N
ATOM	4901	C	ASN	A	607	−1.549	−40.053	−7.267	1.00	43.27	C
ATOM	4902	O	ASN	A	607	−0.445	−39.723	−7.732	1.00	46.72	O
ATOM	4903	N	SER	A	608	−2.138	−39.423	−6.263	1.00	41.81	N
ATOM	4904	CA	SER	A	608	−1.395	−38.472	−5.456	1.00	48.56	C
ATOM	4905	CB	SER	A	608	−2.344	−37.657	−4.591	1.00	47.17	C
ATOM	4906	OG	SER	A	608	−2.970	−38.916	−3.661	1.00	47.12	O
ATOM	4907	C	SER	A	608	−0.397	−39.211	−4.544	1.00	46.92	C
ATOM	4908	O	SER	A	608	0.412	−38.183	−3.892	1.00	46.75	O
ATOM	4909	N	LYS	A	609	−0.469	−40.537	−4.498	1.00	47.67	N
ATOM	4910	CA	LYS	A	609	0.375	−41.318	−3.597	1.00	45.38	C
ATOM	4911	CB	LYS	A	609	−0.474	−42.236	−2.717	1.00	48.04	C
ATOM	4912	CG	LYS	A	609	−1.327	−41.462	−1.719	1.00	51.99	C
ATOM	4913	CD	LYS	A	609	−2.304	−42.149	−0.968	1.00	58.45	C
ATOM	4914	CE	LYS	A	609	−3.005	−41.542	0.113	1.00	62.26	C
ATOM	4915	NZ	LYS	A	609	−3.714	−42.405	1.098	1.00	68.97	N
ATOM	4916	C	LYS	A	609	1.455	−42.210	−4.312	1.00	43.47	C
ATOM	4917	O	LYS	A	609	2.539	−42.317	−3.756	1.00	44.38	O
ATOM	4918	N	LYS	A	610	1.173	−42.546	−5.541	1.00	39.76	N
ATOM	4919	CA	LYS	A	610	2.090	−43.450	−6.247	1.00	34.16	C
ATOM	4920	CB	LYS	A	610	1.863	−44.884	−5.808	1.00	35.25	C
ATOM	4921	CG	LYS	A	610	0.415	−45.327	−5.885	1.00	40.18	C
ATOM	4922	CD	LYS	A	610	0.090	−46.488	−4.949	1.00	46.15	C
ATOM	4923	CE	LYS	A	610	−1.253	−47.092	−5.388	1.00	52.18	C
ATOM	4924	NZ	LYS	A	610	−1.886	−48.014	−4.394	1.00	51.75	N
ATOM	4925	C	LYS	A	610	2.022	−43.338	−7.756	1.00	32.41	C
ATOM	4926	O	LYS	A	610	1.085	−42.765	−8.304	1.00	30.34	O
ATOM	4927	N	VAL	A	611	3.049	−43.878	−8.410	1.00	30.71	N
ATOM	4928	CA	VAL	A	611	3.200	−43.864	−9.867	1.00	29.29	C
ATOM	4929	CB	VAL	A	611	4.328	−42.892	−10.308	1.00	26.64	C
ATOM	4930	CG1	VAL	A	611	4.514	−42.879	−11.823	1.00	25.87	C
ATOM	4931	CG2	VAL	A	611	3.992	−41.490	−9.856	1.00	27.81	C
ATOM	4932	C	VAL	A	611	3.552	−45.284	−10.259	1.00	30.10	C
ATOM	4933	O	VAL	A	611	4.278	−45.962	−9.522	1.00	33.64	O
ATOM	4934	N	TRP	A	612	3.040	−45.156	−11.393	1.00	29.97	N
ATOM	4935	CA	TRP	A	612	3.306	−47.136	−11.807	1.00	29.28	C
ATOM	4936	CB	TRP	A	612	2.388	−48.120	−11.085	1.00	31.57	C
ATOM	4937	CG	TRP	A	612	0.907	−48.007	−11.434	1.00	34.40	C
ATOM	4938	CD1	TRP	A	612	0.240	−48.705	−12.408	1.00	35.80	C
ATOM	4939	NE1	TRP	A	612	−1.100	−48.363	−12.406	1.00	36.76	N
ATOM	4940	CE2	TRP	A	612	−1.312	−47.426	−11.427	1.00	34.76	C
ATOM	4941	CD2	TRP	A	612	−0.066	−47.175	−10.800	1.00	32.54	C
ATOM	4942	CE3	TRP	A	612	−0.014	−46.249	−9.761	1.00	35.88	C
ATOM	4943	CZ3	TRP	A	612	−1.221	−45.596	−9.373	1.00	35.89	C
ATOM	4944	CH2	TRP	A	612	−2.426	−45.872	−10.024	1.00	33.04	C
ATOM	4945	CZ2	TRP	A	612	−2.493	−46.772	−11.053	1.00	32.19	C
ATOM	4946	C	TRP	A	612	3.150	−47.273	−13.296	1.00	28.46	C
ATOM	4947	O	TRP	A	612	2.615	−46.371	−13.905	1.00	29.52	O
ATOM	4948	N	TYR	A	613	3.660	−48.369	−13.870	1.00	26.94	N
ATOM	4949	CA	TYR	A	613	3.452	−48.672	−15.267	1.00	26.79	C
ATOM	4950	CB	TYR	A	613	4.763	−48.991	−15.981	1.00	28.09	C
ATOM	4951	CG	TYR	A	613	5.823	−47.918	−15.906	1.00	30.59	C
ATOM	4952	CD1	TYR	A	613	5.760	−46.790	−16.701	1.00	31.35	C
ATOM	4953	CE1	TYR	A	613	6.726	−45.812	−16.628	1.00	30.54	C
ATOM	4954	CZ	TYR	A	613	7.806	−45.989	−15.779	1.00	33.09	C
ATOM	4955	OH	TYR	A	613	8.767	−45.021	−15.683	1.00	31.56	O
ATOM	4956	CE2	TYR	A	613	7.907	−47.110	−14.983	1.00	31.40	C
ATOM	4957	CD2	TYR	A	613	6.919	−48.061	−15.055	1.00	33.28	C
ATOM	4958	C	TYR	A	613	2.450	−49.833	−15.410	1.00	26.01	C
ATOM	4959	O	TYR	A	613	2.283	−50.655	−14.517	1.00	26.96	O
ATOM	4960	N	GLU	A	614	1.753	−49.867	−16.524	1.00	24.95	N
ATOM	4961	CA	GLU	A	614	0.920	−51.019	−16.882	1.00	26.42	C
ATOM	4962	CB	GLU	A	614	−0.578	−50.696	−16.748	1.00	23.76	C
ATOM	4963	CG	GLU	A	614	−0.931	−49.958	−15.460	1.00	25.71	C
ATOM	4964	CD	GLU	A	614	−2.451	−49.812	−15.223	1.00	28.65	C
ATOM	4965	OE1	GLU	A	614	−3.210	−49.874	−16.198	1.00	28.30	O
ATOM	4966	OE2	GLU	A	614	−2.897	−49.610	−14.065	1.00	28.34	O
ATOM	4967	C	GLU	A	614	1.279	−51.237	−18.333	1.00	24.92	C
ATOM	4968	O	GLU	A	614	1.553	−50.266	−19.042	1.00	25.71	O
ATOM	4969	N	TRP	A	615	1.324	−52.489	−18.772	1.00	22.44	N
ATOM	4970	CA	TRP	A	615	1.684	−52.767	−20.159	1.00	22.31	C
ATOM	4971	C3	TRP	A	615	3.221	−53.010	−20.284	1.00	19.67	C
ATOM	4972	CG	TRP	A	615	3.778	−54.113	−19.399	1.00	16.52	C
ATOM	4973	CD1	TRP	A	615	4.084	−55.373	−19.795	1.00	15.70	C
ATOM	4974	NE1	TRP	A	615	4.553	−56.116	−18.714	1.00	16.37	N
ATOM	4975	CE2	TRP	A	615	4.629	−55.311	−17.613	1.00	15.84	C
ATOM	4976	CD2	TRP	A	615	4.136	−54.028	−18.000	1.00	16.48	C
ATOM	4977	CE3	TRP	A	615	4.098	−52.994	−17.038	1.00	17.46	C
ATOM	4978	CZ3	TRP	A	615	4.541	−53.271	−15.732	1.00	17.49	C
ATOM	4979	CH2	TRP	A	615	5.056	−54.591	−15.388	1.00	17.84	C
ATOM	4980	CZ2	TRP	A	615	5.082	−55.604	−16.314	1.00	16.05	C
ATOM	4981	C	TRP	A	615	0.893	−53.954	−20.701	1.00	22.95	C
ATOM	4982	O	TRP	A	615	0.466	−54.770	−19.923	1.00	25.17	O
ATOM	4983	N	ALA	A	616	0.679	−54.025	−22.018	1.00	23.43	N
ATOM	4984	CA	ALA	A	616	0.108	−55.217	−22.633	1.00	27.16	C
ATOM	4985	CB	ALA	A	616	−1.431	−55.162	−22.656	1.00	25.50	C
ATOM	4986	C	ALA	A	616	0.638	−55.375	−24.036	1.00	29.00	C
ATOM	4987	O	ALA	A	616	0.978	−54.387	−24.670	1.00	34.74	O
ATOM	4988	N	VAL	A	617	0.678	−56.621	−24.510	1.00	28.81	N
ATOM	4989	CA	VAL	A	617	1.000	−56.927	−25.883	1.00	29.23	C
ATOM	4990	CB	VAL	A	617	1.801	−58.256	−25.986	1.00	29.40	C
ATOM	4991	CG1	VAL	A	617	2.138	−58.612	−27.435	1.00	25.91	C
ATOM	4992	CG2	VAL	A	617	3.066	−58.188	−25.145	1.00	28.39	C
ATOM	4993	C	VAL	A	617	−0.326	−57.138	−26.576	1.00	31.60	C
ATOM	4994	O	VAL	A	617	−1.187	−57.859	−26.069	1.00	32.66	O
ATOM	4995	N	THR	A	618	−0.488	−56.534	−27.745	1.00	32.43	N
ATOM	4996	CA	THR	A	618	−1.729	−56.688	−28.470	1.00	37.18	C
ATOM	4997	CB	THR	A	618	−2.426	−55.331	−28.631	1.00	36.52	C
ATOM	4998	OG1	THR	A	618	−1.536	−54.433	−29.297	1.00	40.33	O
ATOM	4999	CG2	THR	A	618	−2.758	−54.745	−27.262	1.00	33.30	C
ATOM	5000	C	THR	A	618	−1.531	−57.384	−29.816	1.00	39.11	C
ATOM	5001	O	THR	A	618	−2.498	−57.545	−30.524	1.00	42.16	O
ATOM	5002	N	ALA	A	619	−0.279	−57.571	−30.174	1.00	38.66	N
ATOM	5003	CA	ALA	A	619	0.045	−58.379	−31.425	1.00	36.77	C
ATOM	5004	CB	ALA	A	619	0.047	−57.418	−32.607	1.00	34.93	C
ATOM	5005	C	ALA	A	619	1.411	−59.960	−31.290	1.00	40.19	C
ATOM	5006	O	ALA	A	619	2.332	−58.461	−30.719	1.00	39.98	O
ATOM	5007	N	PRO	A	620	1.577	−60.266	−31.883	1.00	39.98	N
ATOM	5008	CA	PRO	A	620	0.663	−60.358	−32.860	1.00	44.00	C
ATOM	5009	CB	PRO	A	620	1.527	−61.917	−33.543	1.00	41.97	C
ATOM	5010	CG	PRO	A	620	2.453	−62.366	−32.474	1.00	40.49	C
ATOM	5011	CD	PRO	A	620	2.726	−61.153	−31.621	1.00	42.13	C
ATOM	5012	C	PRO	A	620	−0.514	−61.514	−32.191	1.00	43.86	C
ATOM	5013	O	PRO	A	620	−1.420	−61.960	−32.869	1.00	53.37	O
ATOM	5014	N	VAL	A	621	−0.477	−61.551	−30.867	1.00	44.26	N
ATOM	5015	CA	VAL	A	621	−1.508	−62.132	−30.033	1.00	43.92	C
ATOM	5016	CB	VAL	A	621	−1.113	−63.573	−29.682	1.00	44.45	C
ATOM	5017	CG1	VAL	A	621	−0.618	−63.593	−28.250	1.00	41.70	C
ATOM	5018	CG2	VAL	A	621	−2.286	−64.495	−29.957	1.00	51.65	C
ATOM	5019	C	VAL	A	621	−1.595	−61.208	−28.812	1.00	42.77	C
ATOM	5020	O	VAL	A	621	−0.695	−60.393	−28.620	1.00	46.48	O
ATOM	5021	N	CYS	A	622	−2.659	−61.297	−28.011	1.00	37.06	N
ATOM	5022	CA	CYS	A	622	−2.821	−60.425	−26.858	1.00	32.33	C
ATOM	5023	CB	CYS	A	622	−4.303	−60.107	−26.619	1.00	36.29	C
ATOM	5024	SG	CYS	A	622	−4.865	−58.591	−27.375	1.00	41.40	S
ATOM	5025	C	CYS	A	622	−2.325	−61.067	−25.592	1.00	31.02	C
ATOM	5026	O	CYS	A	622	−2.424	−62.281	−25.437	1.00	32.77	O
ATOM	5027	N	SER	A	623	−1.881	−60.243	−24.647	1.00	29.02	N
ATOM	5028	CA	SER	A	623	−1.665	−60.700	−23.273	1.00	28.10	C
ATOM	5029	CB	SER	A	623	−0.279	−60.278	−22.794	1.00	26.61	C
ATOM	5030	OG	SER	A	623	−0.235	−58.882	−22.527	1.00	26.07	O
ATOM	5031	C	SER	A	623	−2.689	−60.064	−22.342	1.00	28.29	C
ATOM	5032	O	SER	A	623	−3.436	−59.167	−22.725	1.00	28.98	O
ATOM	5033	N	ALA	A	624	−2.700	−60.526	−21.110	1.00	27.76	N
ATOM	5034	CA	ALA	A	624	−3.332	−59.810	−20.042	1.00	29.60	C
ATOM	5035	CB	ALA	A	624	−3.217	−60.609	−18.760	1.00	27.00	C
ATOM	5036	C	ALA	A	624	−2.650	−58.461	−19.868	1.00	34.19	C
ATOM	5037	O	ALA	A	624	−1.422	−58.318	−20.114	1.00	40.81	O
ATOM	5038	N	ILE	A	625	−3.439	−57.468	−19.460	1.00	33.95	N
ATOM	5039	CA	ILE	A	625	−2.905	−56.203	−19.006	1.00	32.45	C
ATOM	5040	CB	ILE	A	625	−4.024	−55.177	−18.753	1.00	30.13	C
ATOM	5041	CG1	ILE	A	625	−4.553	−54.655	−20.101	1.00	34.84	C
ATOM	5042	CD1	ILE	A	625	−5.952	−54.045	−20.030	1.00	31.34	C
ATOM	5043	CG2	ILE	A	625	−3.529	−53.990	−17.928	1.00	27.13	C
ATOM	5044	C	ILE	A	625	−2.084	−56.485	−17.740	1.00	32.13	C
ATOM	5045	O	ILE	A	625	−2.580	−57.104	−16.798	1.00	32.88	O
ATOM	5046	N	HIS	A	626	−0.830	−56.040	−17.725	1.00	27.24	N
ATOM	5047	CA	HIS	A	626	0.034	−56.259	−16.575	1.00	26.03	C
ATOM	5048	CB	HIS	A	626	1.473	−56.490	−17.043	1.00	28.39	C
ATOM	5049	CG	HIS	A	626	1.706	−57.879	−17.531	1.00	30.28	C
ATOM	5050	ND1	HIS	A	626	1.142	−58.360	−18.691	1.00	30.98	N
ATOM	5051	CE1	HIS	A	626	1.501	−59.619	−18.867	1.00	31.27	C
ATOM	5052	NE2	HIS	A	626	2.252	−59.583	−17.841	1.00	32.81	N
ATOM	5053	CD2	HIS	A	626	2.393	−58.913	−16.987	1.00	30.97	C
ATOM	5054	C	HIS	A	626	−0.014	−55.137	−15.575	1.00	24.55	C
ATOM	5055	O	HIS	A	626	−0.097	−53.962	−15.943	1.00	24.63	O
ATOM	5056	N	ASN	A	627	0.044	−55.496	−14.298	1.00	23.08	N
ATOM	5057	CA	ASN	A	627	−0.020	−54.510	−13.205	1.00	24.02	C
ATOM	5058	CB	ASN	A	627	1.263	−53.699	−13.172	1.00	22.76	C
ATOM	5059	CG	ASN	A	627	1.520	−53.081	−11.842	1.00	22.18	C
ATOM	5060	OD1	ASN	A	627	1.189	−53.657	−10.820	1.00	23.85	O
ATOM	5061	ND2	ASN	A	627	2.162	−51.925	−11.838	1.00	23.07	N
ATOM	5062	C	ASN	A	627	−1.245	−53.545	−13.185	1.00	26.56	C
ATOM	5063	O	ASN	A	627	−1.109	−52.382	−12.770	1.00	28.15	O
ATOM	5064	N	PRO	A	628	−2.445	−54.032	−13.574	1.00	27.25	N
ATOM	5065	CA	PRO	A	628	−3.616	−53.159	−13.500	1.00	26.95	C
ATOM	5066	CB	PRO	A	628	−4.773	−54.140	−13.675	1.00	28.74	C
ATOM	5067	CG	PRO	A	628	−4.238	−55.455	−13.241	1.00	27.58	C
ATOM	5068	CD	PRO	A	628	−2.840	−55.439	−13.789	1.00	27.24	C
ATOM	5069	C	PRO	A	628	−3.737	−52.547	−12.136	1.00	27.28	C
ATOM	5070	O	PRO	A	628	−3.804	−53.295	−11.168	1.00	29.56	O
ATOM	5071	N	THR	A	629	−3.760	−51.216	−12.022	1.00	28.21	N
ATOM	5072	CA	THR	A	629	−3.984	−50.598	−10.700	1.00	30.64	C
ATOM	5073	CB	THR	A	629	−5.185	−51.310	−9.983	1.00	33.47	C
ATOM	5074	OG1	THR	A	629	−6.420	−50.716	−10.420	1.00	35.52	O
ATOM	5075	CG2	THR	A	629	−5.119	−51.306	−8.471	1.00	32.79	C
ATOM	5076	C	THR	A	629	−2.730	−50.479	−9.800	1.00	30.81	C
ATOM	5077	O	THR	A	629	−2.791	−49.934	−8.702	1.00	30.13	O
ATOM	5078	N	GLY	A	630	−1.583	−50.963	−10.263	1.00	32.03	N
ATOM	5079	CA	GLY	A	630	−0.407	−50.998	9.386	1.00	31.61	C
ATOM	5080	C	GLY	A	630	−0.599	−52.054	−8.321	1.00	32.28	C
ATOM	5081	O	GLY	A	630	−0.152	−51.906	−7.192	1.00	34.33	O
ATOM	5082	N	ARG	A	631	−1.283	−53.135	−8.678	1.00	34.44	N
ATOM	5083	CA	ARG	A	631	−1.624	−54.149	−7.704	1.00	33.67	C
ATOM	5084	CB	ARG	A	631	−2.679	−55.103	−8.274	1.00	32.97	C
ATOM	5085	CG	ARG	A	631	−2.172	−55.955	−9.438	1.00	29.11	C
ATOM	5086	CD	ARG	A	631	−3.075	−57.143	−9.658	1.00	26.90	C
ATOM	5087	NE	ARG	A	631	−2.746	−57.786	−10.910	1.00	26.60	N
ATOM	5088	CZ	ARG	A	631	−3.599	−58.487	−11.655	1.00	29.54	C
ATOM	5089	NH1	ARG	A	631	−4.888	−58.606	−11.292	1.00	28.56	N
ATOM	5090	NH2	ARG	A	631	−3.171	−59.026	−12.798	1.00	24.76	N
ATOM	5091	C	ARG	A	631	−0.371	−54.924	−7.284	1.00	36.83	C
ATOM	5092	O	ARG	A	631	−0.317	−55.427	−6.173	1.00	39.92	O
ATOM	5093	N	SER	A	632	0.619	−55.013	−8.176	1.00	35.89	N
ATOM	5094	CA	SER	A	632	1.862	−55.753	−7.908	1.00	39.28	C
ATOM	5095	CB	SER	A	632	2.165	−56.750	−9.037	1.00	39.77	C
ATOM	5096	OG	SER	A	632	1.029	−57.544	−9.328	1.00	42.56	O
ATOM	5097	C	SER	A	632	3.094	−54.875	−7.670	1.00	38.25	C
ATOM	5098	O	SER	A	632	4.034	−55.311	−7.026	1.00	42.10	O
ATOM	5099	N	TYR	A	633	3.074	−53.643	−8.163	1.00	38.88	N
ATOM	5100	CA	TYR	A	633	4.205	−52.721	−8.041	1.00	37.34	C
ATOM	5101	CB	TYR	A	633	5.318	−53.135	−9.001	1.00	43.23	C
ATOM	5102	CG	TYR	A	633	6.089	−52.028	−9.673	1.00	47.49	C
ATOM	5103	CD1	TYR	A	633	7.255	−51.530	−9.104	1.00	52.62	C
ATOM	5104	CE1	TYR	A	633	7.979	−50.524	−9.720	1.00	55.61	C
ATOM	5105	CZ	TYR	A	633	7.539	−49.999	−10.928	1.00	59.81	C
ATOM	5106	OR	TYR	A	633	8.284	−48.988	−11.541	1.00	65.89	O
ATOM	5107	CE2	TYR	A	633	6.378	−50.484	−11.515	1.00	50.57	C
ATOM	5108	CD2	TYR	A	633	5.682	−51.509	−10.896	1.00	43.26	C
ATOM	5109	C	TYR	A	633	3.766	−51.289	−8.305	1.00	37.34	C
ATOM	5110	O	TYR	A	633	3.054	−51.022	−9.291	1.00	37.53	O
ATOM	5111	N	THR	A	634	4.174	−50.399	−7.394	1.00	35.61	N
ATOM	5112	CA	THR	A	634	4.106	−48.941	−7.534	1.00	35.41	C
ATOM	5113	CB	THR	A	634	2.999	−48.362	−6.659	1.00	33.01	C
ATOM	5114	OG1	THR	A	634	3.226	−48.788	−5.308	1.00	49.65	O
ATOM	5115	CG2	THR	A	634	1.608	−48.829	−7.121	1.00	37.53	C
ATOM	5116	C	THR	A	634	5.408	−48.302	−7.008	1.00	37.80	C
ATOM	5117	O	THR	A	634	6.196	−48.933	−6.291	1.00	34.42	O
ATOM	5118	N	ILE	A	635	5.604	−47.034	−7.343	1.00	37.14	N
ATOM	5119	CA	ILE	A	635	6.688	−46.232	−6.801	1.00	3.54	C
ATOM	5120	CE	ILE	A	635	7.487	−45.585	−7.941	1.00	35.15	C
ATOM	5121	CG1	ILE	A	635	7.984	−46.651	−8.906	1.00	37.42	C
ATOM	5122	CD1	ILE	A	635	7.760	−46.254	−10.356	1.00	42.58	C
ATOM	5123	CG2	ILE	A	635	8.667	−44.805	−7.414	1.00	34.70	C
ATOM	5124	C	ILE	A	635	6.039	−45.157	−5.942	1.00	35.55	C
ATOM	5125	O	ILE	A	635	5.157	−44.433	−6.413	1.00	35.81	O
ATOM	5126	N	GLY	A	636	6.447	−45.069	−4.679	1.00	33.67	N
ATOM	5127	CA	GLY	A	636	5.824	−44.133	−3.767	1.00	32.06	C
ATOM	5128	C	GLY	A	636	6.189	−42.670	−3.990	1.00	35.89	C
ATOM	5129	O	GLY	A	636	7.386	−42.321	−4.135	1.00	33.11	O
ATOM	5130	N	LEU	A	637	5.159	−41.815	−3.983	1.00	34.23	N
ATOM	5131	CA	LEU	A	637	5.310	−40.348	−3.984	1.00	37.38	C
ATOM	5132	CB	LEU	A	637	4.096	−39.670	−4.629	1.00	40.29	C
ATOM	5133	CG	LEU	A	637	4.205	−39.649	−6.143	1.00	38.91	C
ATOM	5134	CD1	LEU	A	637	2.946	−39.042	−6.687	1.00	38.94	C
ATOM	5135	CD2	LEU	A	637	5.440	−38.870	−6.589	1.00	36.40	C
ATOM	5136	C	LEU	A	637	5.541	−39.729	−2.606	1.00	38.18	C
ATOM	5137	O	LEU	A	637	5.693	−40.447	−1.617	1.00	42.38	O
ATOM	5138	N	LEU	B	19	45.135	−123.802	−20.014	1.00	122.04	N
ATOM	5139	CA	LEU	B	19	45.158	−122.321	−20.781	1.00	125.22	C
ATOM	5140	CB	LEU	B	19	44.740	−121.324	−19.897	1.00	122.10	C
ATOM	5141	CG	LEU	B	19	45.477	−120.970	−18.590	1.00	119.63	C
ATOM	5142	CD1	LEU	B	19	45.526	−119.459	−18.391	1.00	108.38	C
ATOM	5143	CD2	LEU	B	19	44.889	−121.662	−17.360	1.00	113.33	C
ATOM	5144	C	LEU	B	19	46.523	−122.281	−21.453	1.00	128.86	C
ATOM	5145	O	LEU	B	19	47.563	−122.341	−20.789	1.00	126.81	O
ATOM	5146	N	PRO	B	20	46.519	−122.034	−22.782	1.00	131.42	N
ATOM	5147	CA	PRO	B	20	47.705	−121.697	−23.594	1.00	133.21	C
ATOM	5148	CB	PRO	B	20	47.107	−121.460	−24.987	1.00	126.10	C
ATOM	5149	CG	PRO	B	20	45.903	−122.330	−25.015	1.00	122.61	C
ATOM	5150	CD	PRO	B	20	45.332	−122.262	−23.629	1.00	126.00	C
ATOM	5151	C	PRO	B	20	48.466	−120.440	−23.122	1.00	135.70	C
ATOM	5152	O	PRO	B	20	47.963	−119.718	−22.253	1.00	129.20	O
ATOM	5153	N	PRO	B	21	49.677	−120.186	−23.681	1.00	142.28	N
ATOM	5154	CA	PRO	B	21	50.398	−118.937	−23.389	1.00	142.60	C
ATOM	5155	CB	PRO	B	21	51.748	−119.133	−24.096	1.00	137.99	C
ATOM	5156	CG	PRO	B	21	51.482	−120.143	−25.160	1.00	137.69	C
ATOM	5157	CD	PRO	B	21	50.472	−121.074	−24.555	1.00	142.20	C
ATOM	5158	C	PRO	B	21	49.673	−117.215	−23.963	1.00	144.51	C
ATOM	5159	O	PRO	B	21	48.983	−117.838	−24.984	1.00	146.22	O
ATOM	5160	N	ASN	B	22	49.822	−116.561	−23.301	1.00	137.84	N
ATOM	5161	CA	ASN	B	22	49.198	−115.289	−23.725	1.00	132.31	C
ATOM	5162	CB	ASN	B	22	49.565	−114.969	−25.194	1.00	128.60	C
ATOM	5163	CG	ASN	B	22	48.894	−113.712	−25.724	1.00	118.32	C
ATOM	5164	OD1	ASN	B	22	48.950	−112.655	−25.099	1.00	116.11	O
ATOM	5165	ND2	ASN	B	22	48.268	−113.822	−26.896	1.00	113.32	N
ATOM	5166	C	ASN	B	32	47.674	−115.223	−23.479	1.00	132.28	C
ATOM	5167	O	ASN	B	32	47.079	−114.138	−23.467	1.00	122.50	O
ATOM	5168	N	ALA	B	23	47.059	−116.387	23.268	1.00	131.82	N
ATOM	5169	CA	ALA	B	23	45.619	−116.492	−23.036	1.00	130.48	C
ATOM	5170	CB	ALA	B	23	45.158	−117.933	−23.215	1.00	131.09	C
ATOM	5171	C	ALA	B	23	45.233	−115.981	−21.650	1.00	132.56	C
ATOM	5172	O	ALA	B	23	45.935	−116.256	−20.672	1.00	134.71	O
ATOM	5173	N	PRO	B	24	44.122	−115.222	−21.564	1.00	131.61	N
ATOM	5174	CA	PRO	B	24	43.585	−114.810	−20.265	1.00	130.05	C
ATOM	5175	CB	PRO	B	24	42.449	−113.847	−20.637	1.00	129.79	C
ATOM	5176	CG	PRO	B	24	42.745	−113.416	−22.033	1.00	128.82	C
ATOM	5177	CD	PRO	B	24	43.380	−114.609	−22.679	1.00	129.68	C
ATOM	5178	C	PRO	B	24	43.037	−116.008	−19.484	1.00	127.75	C
ATOM	5179	O	PRO	B	24	42.530	−116.965	−20.084	1.00	118.40	O
ATOM	5180	N	ALA	B	25	43.151	−115.947	−18.158	1.00	126.80	N
ATOM	5181	CA	ALA	B	25	42.723	−117.037	−17.276	1.00	126.19	C
ATOM	5182	CB	ALA	B	25	43.270	−116.826	−15.868	1.00	118.51	C
ATOM	5183	C	ALA	B	25	41.199	−117.390	−17.251	1.00	121.78	C
ATOM	5181	O	ALA	B	25	40.676	−118.295	−17.073	1.00	123.15	O
ATOM	5185	N	CYS	B	26	40.501	−116.073	−17.443	1.00	116.91	N
ATOM	5186	CA	CYS	B	26	39.046	−116.035	−17.390	1.00	104.49	C
ATOM	5187	CB	CYS	B	26	38.590	−115.288	−16.137	1.00	104.37	C
ATOM	5188	SG	CYS	B	26	36.797	−115.164	−15.991	1.00	112.51	S
ATOM	5189	C	CYS	B	26	38.460	−115.383	−18.641	1.00	94.78	C
ATOM	5190	O	CYS	B	26	39.060	−114.471	−19.222	1.00	93.14	O
ATOM	5191	N	MET	B	27	37.283	−115.851	−19.048	1.00	83.06	N
ATOM	5192	CA	MET	B	27	36.618	−115.312	−20.231	1.00	75.90	C
ATOM	5193	CB	MET	B	27	36.148	−116.436	−21.158	1.00	74.40	C
ATOM	5194	CG	MET	B	27	35.419	−115.934	−22.395	1.00	73.20	C
ATOM	5195	SD	MET	B	27	35.082	−117.224	−23.593	1.00	77.25	S
ATOM	5196	CE	MET	B	27	33.710	−118.043	−22.820	1.00	74.69	C
ATOM	5197	C	MET	B	27	35.435	−114.409	−19.891	1.00	71.76	C
ATOM	5198	O	MET	B	27	34.529	−114.821	−19.160	1.00	70.50	O
ATOM	5199	N	GLU	B	28	35.456	−113.195	−20.456	1.00	69.16	N
ATOM	5200	CA	GLU	B	28	34.360	−112.205	−20.396	1.00	62.12	C
ATOM	5201	CB	GLU	B	28	34.543	−111.188	−71.522	1.00	57.61	C
ATOM	5202	CG	GLU	B	28	35.469	−110.034	−21.192	1.00	60.60	C
ATOM	5203	CD	GLU	B	28	36.944	−110.373	−21.291	1.00	65.36	C
ATOM	5204	OE1	GLU	B	28	37.290	−111.407	−21.892	1.00	71.13	O
ATOM	5205	OE2	GLU	B	28	37.765	−109.598	−20.764	1.00	65.72	O
ATOM	5206	C	GLU	B	28	32.963	−112.835	−20.488	1.00	56.57	C
ATOM	5207	O	GLU	B	28	32.720	−113.688	−21.332	1.00	55.25	O
ATOM	5208	N	ARG	B	29	32.058	−112.420	−19.610	1.00	56.30	N
ATOM	5209	CA	ARG	B	29	30.757	−113.085	−19.467	1.00	55.73	C
ATOM	5210	CB	ARG	B	29	30.023	−112.555	−18.230	1.00	60.17	C
ATOM	5211	CG	ARG	B	29	28.526	−112.846	−18.177	1.00	65.14	C
ATOM	5212	CD	ARG	B	29	28.190	−114.100	−17.383	1.00	72.48	C
ATOM	5213	NE	ARG	B	29	26.744	−114.314	−17.320	1.00	76.48	N
ATOM	5214	CZ	ARG	B	29	26.156	−115.400	−16.816	1.00	78.40	C
ATOM	5215	NH1	ARG	B	29	24.823	−115.494	−16.813	1.00	74.25	N
ATOM	5216	NH2	ARG	B	29	26.892	−116.393	−16.321	1.00	69.36	N
ATOM	5217	C	ARG	B	29	29.866	−112.995	−20.710	1.00	53.36	C
ATOM	5218	O	ARG	B	29	29.227	−113.987	−21.094	1.00	58.60	O
ATOM	5219	N	GLN	B	30	29.831	−111.828	−21.350	1.00	52.03	N
ATOM	5220	CA	GLN	B	30	28.881	−111.607	−22.445	1.00	52.43	C
ATOM	5221	CB	GLN	B	30	28.360	−110.165	−22.483	1.00	52.12	C
ATOM	5222	CG	GLN	B	30	27.459	−109.810	−21.306	1.00	50.58	C
ATOM	5223	CD	GLN	B	30	28.233	−109.562	−20.013	1.00	47.46	C
ATOM	5224	OE1	GLN	B	30	29.379	−109.075	−20.021	1.00	47.64	O
ATOM	5225	NE2	GLN	B	30	27.606	−109.886	−18.896	1.00	41.54	N
ATOM	5226	C	GLN	B	30	29.437	−112.047	−23.795	1.00	53.91	C
ATOM	5227	O	GLN	B	30	30.243	−111.339	−24.418	1.00	48.03	O
ATOM	5228	N	LEU	B	31	28.988	−113.224	−24.230	1.00	52.77	N
ATOM	5229	CA	LEU	B	31	29.369	−113.765	−25.522	1.00	54.99	C
ATOM	5230	CB	LEU	B	31	29.130	−115.282	−25.562	1.00	54.27	C
ATOM	5231	CG	LEU	B	31	29.895	−116.112	−24.502	1.00	51.55	C
ATOM	5232	CD1	LEU	B	31	29.537	−117.587	−24.557	1.00	46.64	C
ATOM	5233	CD2	LEU	B	31	31.401	−115.919	−24.634	1.00	49.67	C
ATOM	5234	C	LEU	B	31	28.625	−113.046	−26.642	1.00	55.20	C
ATOM	5235	O	LEU	B	31	27.392	−113.026	−26.659	1.00	58.64	O
ATOM	5236	N	GLU	B	32	29.388	−112.458	−27.563	1.00	55.75	N
ATOM	5237	CA	GLU	B	32	28.847	−111.646	−28.654	1.00	55.00	C
ATOM	5238	CB	GLU	B	32	29.635	−110.337	−28.770	1.00	57.15	C
ATOM	5239	CG	GLU	B	32	28.814	−109.171	−29.337	1.00	64.38	C
ATOM	5240	CD	GLU	B	32	27.472	−108.983	−28.629	1.00	62.78	C
ATOM	5241	OE1	GLU	B	32	27.435	−109.026	−27.371	1.00	61.50	O
ATOM	5242	OE2	GLU	B	32	26.453	−108.806	−29.332	1.00	57.80	O
ATOM	5243	C	GLU	B	32	28.808	−112.330	−30.026	1.00	55.64	C
ATOM	5244	O	GLU	B	32	27.918	−112.045	−30.841	1.00	59.67	O
ATOM	5245	N	ALA	B	33	29.774	−113.215	−30.284	1.00	55.92	N
ATOM	5246	CA	ALA	B	33	29.984	−113.777	−31.623	1.00	55.87	C
ATOM	5247	CB	ALA	B	33	30.914	−112.878	−32.431	1.00	54.95	C
ATOM	5248	C	ALA	B	33	30.512	−115.206	−31.618	1.00	57.12	C
ATOM	5249	O	ALA	B	33	31.312	−115.588	−30.756	1.00	53.36	O
ATOM	5250	N	ALA	B	34	30.061	−115.979	−32.607	1.00	62.10	N
ATOM	5251	CA	ALA	B	34	30.468	−117.174	−32.806	1.00	57.99	C
ATOM	5252	CB	ALA	B	34	29.505	−118.311	−32.101	1.00	52.57	C
ATOM	5253	C	ALA	B	34	30.518	−117.695	−34.294	1.00	58.37	C
ATOM	5254	O	ALA	B	34	29.490	−117.630	−34.973	1.00	55.15	O
ATOM	5255	N	ARG	B	35	31.709	−118.044	−34.789	1.00	62.02	N
ATOM	5256	CA	ARG	B	35	31.933	−118.310	−36.226	1.00	62.92	C
ATOM	5257	CB	ARG	B	35	32.549	−117.088	−36.936	1.00	64.58	C
ATOM	5258	CG	ARG	B	35	31.833	−115.760	−36.741	1.00	67.32	C
ATOM	5259	CD	ARG	B	35	30.473	−115.697	−37.424	1.00	66.64	C
ATOM	5260	NE	ARG	B	35	29.674	−114.627	−36.838	1.00	68.37	N
ATOM	5261	CZ	ARG	B	35	29.818	−113.333	−37.120	1.00	70.62	C
ATOM	5262	NH1	ARG	B	35	30.719	−112.922	−38.006	1.00	63.99	N
ATOM	5263	NH2	ARG	B	35	29.048	−112.444	−36.511	1.00	75.51	N
ATOM	5264	C	ARG	B	35	32.828	−119.521	−36.503	1.00	61.65	C
ATOM	5265	O	ARG	B	35	34.024	−119.519	−36.160	1.00	57.20	O
ATOM	5266	N	TYR	B	36	32.257	−120.535	−37.153	1.00	59.56	N
ATOM	5267	CA	TYR	B	36	33.037	−121.691	−37.613	1.00	60.10	C
ATOM	5268	CB	TYR	B	36	32.125	−122.847	−38.000	1.00	58.85	C
ATOM	5269	CG	TYR	B	36	31.583	−123.663	−36.846	1.00	60.85	C
ATOM	5270	CD1	TYR	B	36	32.430	−124.410	−36.033	1.00	59.59	C
ATOM	5271	CE1	TYR	B	36	31.929	−125.170	−34.987	1.00	62.51	C
ATOM	5272	CZ	TYR	B	36	30.563	−125.197	−34.746	1.00	59.97	C
ATOM	5273	OH	TYR	B	36	30.061	−125.945	−33.707	1.00	56.36	O
ATOM	5274	CE2	TYR	B	36	29.701	−124.474	−35.551	1.00	63.47	C
ATOM	5275	CD2	TYR	B	36	30.211	−123.719	−36.596	1.00	62.54	C
ATOM	5276	C	TYR	B	36	33.898	−121.356	−38.824	1.00	64.81	C
ATOM	5277	O	TYR	B	36	33.386	−120.859	−39.832	1.00	63.35	O
ATOM	5278	N	ARG	B	37	35.200	−121.636	−38.715	1.00	64.78	N
ATOM	5279	CA	ARG	B	37	36.118	−121.683	−39.866	1.00	64.49	C
ATOM	5280	CB	ARG	B	37	37.555	−121.731	−39.353	1.00	59.53	C
ATOM	5281	CG	ARG	B	37	38.627	−121.553	−40.401	1.00	57.03	C
ATOM	5282	CD	ARG	B	37	39.962	−121.193	−39.728	1.00	60.91	C
ATOM	5283	NE	ARG	B	37	40.495	−122.450	−39.000	1.00	59.93	N
ATOM	5284	CZ	ARG	B	37	41.706	−122.496	−38.443	1.00	60.38	C
ATOM	5285	NH1	ARG	B	37	42.526	−121.448	−38.521	1.00	56.88	N
ATOM	5286	NH2	ARG	B	37	42.104	−123.593	−37.805	1.00	60.97	N
ATOM	5287	C	ARG	B	37	35.809	−122.931	−40.707	1.00	66.20	C
ATOM	5288	O	ARG	B	37	35.160	−123.857	−40.215	1.00	69.97	O
ATOM	5289	N	SER	B	38	36.260	−122.966	−41.963	1.00	73.01	N
ATOM	5290	CA	SER	B	38	35.964	−124.112	−42.853	1.00	74.02	C
ATOM	5291	CB	SER	B	38	36.388	−123.856	−44.308	1.00	72.12	C
ATOM	5292	OG	SER	B	38	37.533	−123.825	−44.384	1.00	81.51	O
ATOM	5293	C	SER	B	38	36.521	−125.437	−42.328	1.00	76.31	C
ATOM	5294	O	SER	B	38	35.884	−126.485	−42.490	1.00	76.52	O
ATOM	5295	N	ASP	B	39	37.676	−125.583	−41.663	1.00	77.98	N
ATOM	5296	CA	ASP	B	39	38.256	−126.574	−41.020	1.00	79.09	C
ATOM	5297	CB	ASP	B	39	39.723	−126.334	−40.630	1.00	76.84	C
ATOM	5298	CG	ASP	B	39	39.872	−125.623	−39.300	1.00	79.14	C
ATOM	5299	OD1	ASP	B	39	39.002	−124.794	−38.958	1.00	78.59	O
ATOM	5300	OD2	ASP	B	39	40.870	−125.888	−38.595	1.00	77.33	O
ATOM	5301	C	ASP	B	39	37.446	−127.699	−39.818	1.00	80.70	C
ATOM	5302	O	ASP	B	39	37.704	−128.198	−39.325	1.00	87.43	O
ATOM	5303	N	GLY	B	40	36.486	−126.306	−39.341	1.00	80.72	N
ATOM	5304	CA	GLY	B	40	35.549	−126.742	−38.289	1.00	70.56	C
ATOM	5305	C	GLY	B	40	35.811	−126.231	−36.880	1.00	64.86	C
ATOM	5306	O	GLY	B	40	35.085	−126.591	−35.945	1.00	59.32	O
ATOM	5307	N	ALA	B	41	36.855	−125.412	−36.731	1.00	58.55	N
ATOM	5308	CA	ALA	B	41	37.219	−124.790	−35.455	1.00	60.17	C
ATOM	5309	CB	ALA	B	41	38.698	−124.429	−35.457	1.00	56.92	C
ATOM	5310	C	ALA	B	41	36.358	−123.548	−35.127	1.00	63.32	C
ATOM	5311	O	ALA	B	41	35.912	−122.832	−36.037	1.00	64.27	O
ATOM	5312	N	LEU	B	42	36.154	−123.292	−33.829	1.00	63.15	N
ATOM	5313	CA	LEU	B	42	35.267	−122.216	−33.351	1.00	60.47	C
ATOM	5314	CB	LEU	B	42	34.408	−122.703	−32.189	1.00	61.52	C
ATOM	5315	CG	LEU	B	42	33.106	−121.947	−31.913	1.00	62.54	C
ATOM	5316	CD1	LEU	B	42	32.437	−121.435	−33.183	1.00	59.88	C
ATOM	5317	CD2	LEU	B	42	32.144	−122.850	−31.149	1.00	64.25	C
ATOM	5318	C	LEU	B	42	35.965	−120.928	−32.928	1.00	60.17	C
ATOM	5319	O	LEU	B	42	36.839	−120.936	−32.048	1.00	58.84	O
ATOM	5320	N	LEU	B	43	35.560	−119.832	−33.573	1.00	56.67	N
ATOM	5321	CA	LEU	B	43	35.961	−118.474	−33.200	1.00	57.88	C
ATOM	5322	CB	LEU	B	43	36.156	−117.599	−34.444	1.00	55.28	C
ATOM	5323	CG	LEU	B	43	36.432	−116.101	−34.236	1.00	54.55	C
ATOM	5324	CD1	LEU	B	43	37.652	−115.811	−33.360	1.00	54.33	C
ATOM	5325	CD2	LEU	B	43	36.559	−115.401	−35.577	1.00	51.41	C
ATOM	5326	C	LEU	B	43	34.904	−117.836	−32.308	1.00	58.21	C
ATOM	5327	O	LEU	B	43	33.735	−117.721	−32.710	1.00	60.87	O
ATOM	5328	N	LEU	B	44	35.325	−117.428	−31.110	1.00	57.56	N
ATOM	5329	CA	LEU	B	44	34.469	−116.713	−30.150	1.00	55.53	C
ATOM	5330	CB	LEU	B	44	34.402	−117.435	−28.803	1.00	53.04	C
ATOM	5331	CG	LEU	B	44	33.863	−118.855	−28.725	1.00	58.81	C
ATOM	5332	CD1	LEU	B	44	33.851	−119.306	−27.268	1.00	62.93	C
ATOM	5333	CD2	LEU	B	44	32.478	−118.983	−29.336	1.00	55.87	C
ATOM	5334	C	LEU	B	44	34.977	−115.305	−29.890	1.00	53.33	C
ATOM	5335	O	LEU	B	44	36.178	−115.102	−29.669	1.00	52.60	O
ATOM	5336	N	GLY	B	45	34.052	−114.343	−29.915	1.00	54.02	N
ATOM	5337	CA	GLY	B	45	34.292	−112.988	−29.395	1.00	47.39	C
ATOM	5338	C	GLY	B	45	33.418	−112.764	−28.177	1.00	46.88	C
ATOM	5339	O	GLY	B	45	32.250	−113.200	−28.149	1.00	45.83	O
ATOM	5340	N	ALA	B	46	33.979	−112.107	−27.164	1.00	45.98	N
ATOM	5341	CA	ALA	B	46	33.248	−111.811	−25.926	1.00	46.29	C
ATOM	5342	CB	ALA	B	46	33.436	−112.920	−24.896	1.00	46.04	C
ATOM	5343	C	ALA	B	46	33.649	−110.464	−25.324	1.00	48.53	C
ATOM	5344	O	ALA	B	46	34.825	−110.049	−25.414	1.00	44.72	O
ATOM	5345	N	SER	B	47	32.660	−109.804	−24.713	1.00	43.57	N
ATOM	5346	CA	SER	B	47	32.850	−106.517	−24.041	1.00	44.03	C
ATOM	5347	CB	SER	B	47	31.949	−107.415	−24.640	1.00	44.79	C
ATOM	5348	OG	SER	B	47	32.085	−107.258	−26.048	1.00	46.51	O
ATOM	5349	C	SER	B	47	32.519	−108.635	−22.570	1.00	43.23	C
ATOM	5350	O	SER	B	47	31.747	−109.508	−22.145	1.00	43.50	O
ATOM	5351	N	SER	B	48	33.112	−107.743	−21.793	1.00	46.73	N
ATOM	5352	CA	SER	B	48	32.694	−107.509	−20.413	1.00	49.82	C
ATOM	5353	CB	SER	B	48	33.922	−107.320	−19.523	1.00	51.45	C
ATOM	5354	OG	SER	B	48	33.566	−106.762	−18.280	1.00	57.12	O
ATOM	5355	C	SER	B	48	31.812	−106.248	−20.400	1.00	47.36	C
ATOM	5356	O	SER	B	48	32.320	−105.124	−20.480	1.00	33.79	O
ATOM	5357	N	LEU	B	49	30.498	−106.453	−20.325	1.00	46.95	N
ATOM	5358	CA	LEU	B	49	29.533	−105.354	−20.374	1.00	48.39	C
ATOM	5359	CB	LEU	B	49	28.279	−105.786	−21.148	1.00	48.09	C
ATOM	5360	CG	LEU	B	49	28.494	−106.173	−22.615	1.00	47.28	C
ATOM	5361	CD1	LEU	B	49	27.159	−106.417	−23.291	1.00	42.93	C
ATOM	5362	CD2	LEU	B	49	29.330	−105.151	−23.384	1.00	43.35	C
ATOM	5363	C	LEU	B	49	29.119	−104.795	−19.002	1.00	53.14	C
ATOM	5364	O	LEU	B	49	28.250	−103.903	−18.921	1.00	54.59	O
ATOM	5365	N	SER	B	50	29.727	−105.320	−17.935	1.00	48.18	N
ATOM	5366	CA	SER	B	50	29.417	−104.899	−16.578	1.00	47.02	C
ATOM	5367	CB	SER	B	50	28.179	−105.642	−16.083	1.00	46.27	C
ATOM	5368	OG	SER	B	50	27.602	−104.949	−15.003	1.00	41.36	O
ATOM	5369	C	SER	B	50	30.608	−105.119	−15.645	1.00	51.44	C
ATOM	5370	O	SER	B	50	31.643	−105.635	−16.074	1.00	59.56	O
ATOM	5371	N	GLY	B	51	30.483	−104.714	−14.379	1.00	51.37	N
ATOM	5372	CA	GLY	B	51	31.595	−104.803	−13.435	1.00	45.64	C
ATOM	5373	C	GLY	B	51	32.710	−103.810	−13.746	1.00	49.05	C
ATOM	5374	O	GLY	B	51	32.555	−102.938	−14.597	1.00	49.85	O
ATOM	5375	N	ARG	B	52	33.845	−103.957	−13.062	1.00	48.23	N
ATOM	5376	CA	ARG	B	52	34.892	−102.947	−13.058	1.00	43.11	C
ATOM	5377	CB	ARG	B	52	36.012	−103.327	−12.074	1.00	50.58	C
ATOM	5378	CG	ARG	B	52	37.191	−102.346	−12.051	1.00	50.59	C
ATOM	5379	CD	ARG	B	52	38.425	−102.968	−11.405	1.00	58.68	C
ATOM	5380	NE	ARG	B	52	38.276	−103.133	−9.957	1.00	63.00	N
ATOM	5381	CZ	ARG	B	52	38.892	−102.389	−9.036	1.00	64.43	C
ATOM	5382	NH1	ARG	B	52	39.731	−101.428	−9.407	1.00	66.95	N
ATOM	5383	NH2	ARG	B	52	38.673	−102.609	−7.739	1.00	63.06	N
ATOM	5384	C	ARG	B	52	35.486	−102.666	−14.438	1.00	47.71	C
ATOM	5385	O	ARG	B	52	35.681	−101.517	−14.817	1.00	48.24	O
ATOM	5386	N	CYS	B	53	35.795	−103.719	−15.172	1.00	50.01	N
ATOM	5387	CA	CYS	B	53	36.554	−103.581	−16.393	1.00	54.14	C
ATOM	5388	CB	CYS	B	53	37.750	−104.540	−16.364	1.00	63.31	C
ATOM	5389	SG	CYS	B	53	39.000	−104.183	−17.624	1.00	86.33	S
ATOM	5390	C	CYS	B	53	35.658	−103.850	−17.595	1.00	49.46	C
ATOM	5391	O	CYS	B	53	35.057	−104.908	−17.702	1.00	43.16	O
ATOM	5392	N	TRP	B	54	35.548	−102.884	−18.495	1.00	50.85	N
ATOM	5393	CA	TRP	B	54	34.698	−103.082	−19.666	1.00	54.37	C
ATOM	5394	CB	TRP	B	54	33.767	−101.885	−19.919	1.00	54.51	C
ATOM	5395	CG	TRP	B	54	32.683	−101.659	−18.882	1.00	54.18	C
ATOM	5396	CD1	TRP	B	54	32.276	−102.316	−17.885	1.00	54.37	C
ATOM	5397	NE1	TRP	B	54	31.243	−101.950	−17.161	1.00	53.97	N
ATOM	5398	CE2	TRP	B	54	30.961	−100.717	−17.692	1.00	54.25	C
ATOM	5399	CD2	TRP	B	54	31.844	−100.503	−18.779	1.00	53.42	C
ATOM	5400	CE3	TRP	B	54	31.757	−99.300	−19.498	1.00	51.81	C
ATOM	5401	CZ3	TRP	B	54	30.807	−98.365	−19.123	1.00	49.71	C
ATOM	5402	CH2	TRP	B	54	29.951	−98.601	−18.032	1.00	53.72	C
ATOM	5403	CZ2	TRP	B	54	30.010	−99.768	−17.306	1.00	56.60	C
ATOM	5404	C	TRP	B	54	35.566	−103.392	−20.870	1.00	50.79	C
ATOM	5405	O	TRP	B	54	36.005	−102.511	−21.599	1.00	52.17	O
ATOM	5406	N	ALA	B	55	35.824	−104.669	−21.067	1.00	53.99	N
ATOM	5407	CA	ALA	B	55	36.799	−105.062	−22.066	1.00	55.25	C
ATOM	5408	CB	ALA	B	55	38.094	−105.509	−21.391	1.00	53.09	C
ATOM	5409	C	ALA	B	55	36.251	−106.152	−22.969	1.00	53.39	C
ATOM	5410	O	ALA	B	55	35.034	−106.393	−23.026	1.00	48.98	O
ATOM	5411	N	GLY	B	SG	37.171	−106.801	−23.672	1.00	52.41	N
ATOM	5412	CA	GLY	B	56	36.836	−107.825	−24.636	1.00	54.87	C
ATOM	5413	C	GLY	B	56	38.002	−108.140	−24.948	1.00	51.99	C
ATOM	5414	O	GLY	B	56	39.166	−108.416	−24.695	1.00	56.59	O
ATOM	5415	N	SER	B	57	37.668	−109.878	−25.529	1.00	48.06	N
ATOM	5416	CA	SER	B	57	38.603	−110.947	−25.751	1.00	49.26	C
ATOM	5417	CB	SER	B	57	38.667	−111.843	−24.516	1.00	44.78	C
ATOM	5418	OG	SER	B	57	37.444	−112.317	−24.349	1.00	48.55	O
ATOM	5419	C	SER	B	57	38.235	−111.768	−26.984	1.00	51.52	C
ATOM	5420	O	SER	B	57	37.062	−111.819	−27.411	1.00	49.00	O
ATOM	5421	N	LEU	B	58	39.258	−112.400	−27.555	1.00	53.96	N
ATOM	5422	CA	LEU	B	58	39.080	−113.262	−28.715	1.00	56.94	C
ATOM	5423	CB	LEU	B	58	39.752	−112.639	−29.950	1.00	56.06	C
ATOM	5424	CG	LEU	B	58	39.375	−111.199	−30.365	1.00	55.08	C
ATOM	5425	CD1	LEU	B	58	40.350	−110.646	−31.392	1.00	54.75	C
ATOM	5426	CD2	LEU	B	58	37.949	−111.691	−30.902	1.00	59.32	C
ATOM	5427	C	LEU	B	58	39.597	−114.680	−28.399	1.00	60.19	C
ATOM	5428	O	LEU	B	58	40.600	−114.844	−27.699	1.00	60.83	O
ATOM	5429	N	TRP	B	59	38.886	−115.692	−28.898	1.00	59.11	N
ATOM	5430	CA	TRP	B	59	39.162	−117.090	−28.581	1.00	58.86	C
ATOM	5431	CB	TRP	B	59	38.201	−117.597	−27.499	1.00	61.66	C
ATOM	5432	CG	TRP	B	59	38.216	−116.789	−26.228	1.00	67.37	C
ATOM	5433	CD1	TRP	B	59	37.444	−115.703	−25.942	1.00	66.43	C
ATOM	5434	NE1	TRP	B	59	37.735	−115.229	−24.689	1.00	66.49	N
ATOM	5435	CE2	TRP	B	59	38.717	−116.605	−24.137	1.00	68.32	C
ATOM	5436	CD2	TRP	B	59	39.047	−117.602	−25.080	1.00	69.61	C
ATOM	5437	CE3	TRP	B	59	40.038	−117.939	−24.756	1.00	68.34	C
ATOM	5438	CZ3	TRP	B	59	40.660	−117.849	−23.514	1.00	67.30	C
ATOM	5439	CH2	TRP	B	59	40.308	−116.843	−22.598	1.00	70.76	C
ATOM	5440	CZ2	TRP	B	59	39.343	−115.915	−22.889	1.00	69.72	C
ATOM	5441	C	TRP	B	59	39.054	−118.003	−29.808	1.00	62.33	C
ATOM	5442	O	TRP	B	59	38.171	−117.821	−30.659	1.00	59.73	O
ATOM	5443	N	LEU	B	60	39.960	−118.983	−29.885	1.00	65.32	N
ATOM	5444	CA	LEU	B	60	39.891	−120.056	−30.889	1.00	66.59	C
ATOM	5445	CB	LEU	B	60	41.073	−119.989	−31.862	1.00	65.79	C
ATOM	5446	CG	LEU	B	60	41.108	−121.033	−32.982	1.00	68.66	C
ATOM	5447	CD1	LEU	B	60	39.847	−121.047	−33.842	1.00	68.50	C
ATOM	5448	CD2	LEU	B	60	42.348	−120.811	−33.834	1.00	72.56	C
ATOM	5449	C	LEU	B	60	39.793	−121.438	−30.247	1.00	63.98	C
ATOM	5450	O	LEU	B	60	40.612	−121.799	−29.393	1.00	62.36	O
ATOM	5451	N	PHE	B	61	38.772	−122.186	−30.665	1.00	65.11	N
ATOM	5452	CA	PHE	B	61	38.482	−123.518	−30.142	1.00	66.17	C
ATOM	5453	CB	PHE	B	61	37.124	−123.532	−29.441	1.00	61.66	C
ATOM	5454	CG	PHE	B	61	37.180	−123.118	−28.001	1.00	64.27	C
ATOM	5455	CD1	PHE	B	61	37.229	−121.771	−27.649	1.00	65.66	C
ATOM	5456	CE1	PHE	B	61	37.280	−121.388	−26.321	1.00	63.55	C
ATOM	5457	CZ	PHE	B	61	37.275	−122.348	−25.325	1.00	61.87	C
ATOM	5458	CE2	PHE	B	61	37.220	−123.692	−25.660	1.00	64.80	C
ATOM	5459	CD2	PHE	B	61	37.168	−124.069	−26.992	1.00	64.27	C
ATOM	5460	C	PHE	B	61	38.499	−124.580	−31.237	1.00	71.20	C
ATOM	5461	O	PHE	B	61	37.505	−124.745	−31.965	1.00	69.73	O
ATOM	5462	N	LYS	B	62	39.620	−125.303	−31.348	1.00	75.64	N
ATOM	5463	CA	LYS	B	62	39.733	−126.401	−32.322	1.00	73.86	C
ATOM	5464	CB	LYS	B	62	41.184	−126.849	−32.517	1.00	73.47	C
ATOM	5465	CG	LYS	B	62	41.873	−126.173	−33.693	1.00	71.94	C
ATOM	5466	CD	LYS	B	62	43.332	−125.877	−33.386	1.00	73.59	C
ATOM	5467	CE	LYS	B	62	44.044	−125.292	−34.596	1.00	76.70	C
ATOM	5468	NZ	LYS	B	62	45.383	−124.742	−34.246	1.00	79.53	N
ATOM	5469	C	LYS	B	62	38.832	−127.557	−31.931	1.00	70.78	C
ATOM	5470	O	LYS	B	62	38.354	−128.279	−32.797	1.00	68.15	O
ATOM	5471	N	ASP	B	63	38.605	−127.710	−30.625	1.00	74.32	N
ATOM	5472	CA	ASP	B	63	37.529	−128.557	−30.098	1.00	73.63	C
ATOM	5473	CB	ASP	B	63	38.004	−129.373	−28.878	1.00	69.99	C
ATOM	5474	CG	ASP	B	63	36.875	−130.187	−28.224	1.00	70.47	C
ATOM	5475	OD1	ASP	B	63	35.813	−130.423	−28.859	1.00	71.18	O
ATOM	5476	OD2	ASP	B	63	37.053	−130.595	−27.058	1.00	70.19	O
ATOM	5477	C	ASP	B	63	36.324	−127.670	−29.736	1.00	73.80	C
ATOM	5478	O	ASP	B	63	36.333	−126.995	−28.698	1.00	70.05	O
ATOM	5479	N	PRO	B	64	35.272	−127.692	−30.578	1.00	75.57	N
ATOM	5480	CA	PRO	B	64	34.127	−126.811	−30.390	1.00	75.22	C
ATOM	5481	CB	PRO	B	64	33.330	−127.001	−31.681	1.00	75.72	C
ATOM	5482	CG	PRO	B	64	33.618	−128.404	−32.081	1.00	78.46	C
ATOM	5483	CD	PRO	B	64	35.034	−128.676	−31.653	1.00	80.07	C
ATOM	5484	C	PRO	B	64	33.274	−127.192	−29.177	1.00	78.38	C
ATOM	5485	O	PRO	B	64	32.573	−126.338	−28.630	1.00	78.07	O
ATOM	5486	N	CYS	B	65	33.343	−128.458	−28.765	1.00	75.54	N
ATOM	5487	CA	CYS	B	65	32.539	−128.962	−27.653	1.00	70.48	C
ATOM	5488	CB	CYS	B	65	32.381	−130.479	−27.753	1.00	74.27	C
ATOM	5489	SG	CYS	B	65	31.359	−131.015	−29.142	1.00	83.37	S
ATOM	5490	C	CYS	B	65	33.125	−128.585	−26.302	1.00	65.15	C
ATOM	5491	O	CYS	B	65	32.470	−128.765	−25.274	1.00	62.17	O
ATOM	5492	N	ALA	B	66	34.353	−128.062	−26.322	1.00	67.16	N
ATOM	5493	CA	ALA	B	66	35.100	−127.655	−25.121	1.00	67.74	C
ATOM	5494	CB	ALA	B	66	36.599	−127.802	−25.360	1.00	61.84	C
ATOM	5495	C	ALA	B	66	34.782	−126.213	−24.722	1.00	71.06	C
ATOM	5496	O	ALA	B	66	34.987	−125.814	−23.575	1.00	72.73	O
ATOM	5497	N	ALA	B	67	34.312	−125.432	−25.690	1.00	73.44	N
ATOM	5498	CA	ALA	B	67	33.871	−124.064	−25.454	1.00	74.62	C
ATOM	5499	CB	ALA	B	67	33.552	−123.388	−26.775	1.00	73.21	C
ATOM	5500	C	ALA	B	67	32.655	−124.056	−24.518	1.00	72.90	C
ATOM	5501	O	ALA	B	67	31.769	−124.912	−24.642	1.00	74.98	O
ATOM	5502	N	PRO	B	68	32.593	−123.081	−23.592	1.00	67.66	N
ATOM	5503	CA	PRO	B	68	33.421	−121.876	−23.466	1.00	64.96	C
ATOM	5504	CB	PRO	B	68	32.405	−120.839	−22.987	1.00	62.70	C
ATOM	5505	CG	PRO	B	68	33.343	−121.625	−22.274	1.00	61.91	C
ATOM	5506	CD	PRO	B	68	31.495	−123.082	−22.610	1.00	62.93	C
ATOM	5507	C	PRO	B	68	34.591	−121.930	−22.476	1.00	67.13	C
ATOM	5508	O	PRO	B	68	35.180	−120.890	−22.181	1.00	66.74	O
ATOM	5509	N	ASN	B	69	34.928	−123.116	−21.972	1.00	74.46	N
ATOM	5510	CA	ASN	B	69	36.024	−123.282	−20.995	1.00	76.32	C
ATOM	5511	CB	ASN	B	69	36.104	−124.739	−20.515	1.00	79.83	C
ATOM	5512	CG	ASN	B	69	37.004	−124.914	−19.296	1.00	84.12	C
ATOM	5513	OD1	ASN	B	69	38.120	−124.377	−19.225	1.00	76.10	O
ATOM	5514	ND2	ASN	B	69	36.522	−125.686	−18.328	1.00	84.17	N
ATOM	5515	C	ASN	B	69	37.394	−122.818	−21.507	1.00	74.95	C
ATOM	5516	O	ASN	B	69	37.905	−123.147	−22.493	1.00	75.84	O
ATOM	5517	N	GLU	B	70	37.984	−121.853	−20.800	1.00	75.29	N
ATOM	5518	CA	GLU	B	70	39.214	−121.154	−21.222	1.00	72.14	C
ATOM	5519	CB	GLU	B	70	39.480	−119.929	−20.331	1.00	70.59	C
ATOM	5520	CG	GLU	B	70	38.303	−118.984	−20.121	1.00	74.54	C
ATOM	5521	CD	GLU	B	70	37.292	−119.478	−19.087	1.00	80.40	C
ATOM	5522	OE1	GLU	B	70	37.696	−120.187	−18.138	1.00	81.12	O
ATOM	5523	OE2	GLU	B	70	36.085	−119.156	−19.220	1.00	79.46	O
ATOM	5524	C	GLU	B	70	40.466	−122.037	−21.220	1.00	74.65	C
ATOM	5525	O	GLU	B	70	41.402	−121.197	−21.993	1.00	74.05	O
ATOM	5526	N	GLY	B	71	40.479	−123.036	−20.336	1.00	75.79	N
ATOM	5527	CA	GLY	B	71	41.588	−123.991	−20.212	1.00	76.90	C
ATOM	5528	C	GLY	B	71	41.730	−124.950	−21.382	1.00	76.63	C
ATOM	5529	O	GLY	B	71	42.838	−125.393	−21.694	1.00	80.23	O
ATOM	5530	N	PHE	B	72	40.609	−125.264	−22.030	1.00	76.43	N
ATOM	5531	CA	PHE	B	72	40.604	−126.157	−23.190	1.00	76.57	C
ATOM	5532	CB	PHE	B	72	39.519	−127.244	−23.066	1.00	85.06	C
ATOM	5533	CG	PHE	B	72	39.420	−127.876	−21.698	1.00	96.46	C
ATOM	5534	CD1	PHE	B	72	40.564	−128.153	−20.938	1.00	97.43	C
ATOM	5535	CE1	PHE	B	72	40.462	−128.733	−19.684	1.00	95.54	C
ATOM	5536	CZ	PHE	B	72	39.215	−129.067	−19.181	1.00	98.02	C
ATOM	5537	CE2	PHE	B	72	38.068	−128.814	−19.928	1.00	101.08	C
ATOM	5538	CD2	PHE	B	72	38.173	−128.226	−21.180	1.00	96.64	C
ATOM	5539	C	PHE	B	72	40.453	−125.411	−24.524	1.00	71.05	C
ATOM	5540	O	PHE	B	72	39.796	−125.896	−25.442	1.00	62.87	O
ATOM	5541	N	CYS	B	73	41.063	−124.238	−24.638	1.00	65.91	N
ATOM	5542	CA	CYS	B	73	41.050	−123.536	−25.911	1.00	68.70	C
ATOM	5543	CB	CYS	B	73	40.790	−122.039	−25.714	1.00	65.55	C
ATOM	5544	SG	CYS	B	73	42.212	−121.052	−25.170	1.00	61.04	S
ATOM	5545	C	CYS	B	73	42.373	−123.750	−26.643	1.00	69.79	C
ATOM	5546	O	CYS	B	73	43.380	−124.092	−26.018	1.00	68.25	O
ATOM	5547	N	SER	B	74	42.358	−123.543	−27.960	1.00	66.27	N
ATOM	5548	CA	SER	B	74	43.574	−123.528	−28.768	1.00	62.43	C
ATOM	5549	CB	SER	B	74	43.242	−123.795	−30.238	1.00	62.44	C
ATOM	5550	OG	SER	B	74	42.206	−124.768	−30.370	1.00	62.11	O
ATOM	5551	C	SER	B	74	44.320	−122.194	−28.606	1.00	67.33	C
ATOM	5552	O	SER	B	74	45.535	−122.180	−28.361	1.00	68.91	O
ATOM	5553	N	ALA	B	75	43.597	−121.075	−28.739	1.00	67.04	N
ATOM	5554	CA	ALA	B	75	44.181	−119.734	−28.518	1.00	63.80	C
ATOM	5555	CB	ALA	B	75	44.750	−119.167	−29.816	1.00	56.92	C
ATOM	5556	C	ALA	B	75	43.205	−118.738	−27.872	1.00	61.56	C
ATOM	5557	O	ALA	B	75	41.995	−118.974	−27.836	1.00	58.17	O
ATOM	5558	N	GLY	B	76	43.756	−117.630	−27.372	1.00	63.02	N
ATOM	5559	CA	GLY	B	76	42.999	−116.590	−26.657	1.00	62.34	C
ATOM	5560	C	GLY	B	76	43.775	−115.290	−26.455	1.00	62.73	C
ATOM	5561	O	GLY	B	76	45.000	−115.309	−26.303	1.00	67.31	O
ATOM	5562	N	VAL	B	77	43.070	−114.157	−26.474	1.00	59.01	N
ATOM	5563	CA	VAL	B	77	43.707	−112.855	−26.239	1.00	59.09	C
ATOM	5564	CB	VAL	B	77	44.520	−112.380	−27.477	1.00	53.25	C
ATOM	5565	CG1	VAL	B	77	43.599	−111.937	−28.605	1.00	53.56	C
ATOM	5566	CG2	VAL	B	77	45.484	−111.258	−27.103	1.00	52.13	C
ATOM	5567	C	VAL	B	77	42.741	−111.749	−25.729	1.00	61.91	C
ATOM	5568	O	VAL	B	77	41.550	−111.734	−26.051	1.00	62.67	O
ATOM	5569	N	GLN	B	78	43.290	−110.827	−24.936	1.00	68.63	N
ATOM	5570	CA	GLN	B	78	42.570	−109.660	−24.429	1.00	71.74	C
ATOM	5571	CB	GLN	B	78	43.208	−109.194	−23.113	1.00	72.99	C
ATOM	5572	CG	GLN	B	78	42.308	−108.367	−22.200	1.00	85.58	C
ATOM	5573	CD	GLN	B	78	41.186	−109.174	−21.551	1.00	91.02	C
ATOM	5574	OE1	GLN	B	78	41.285	−110.394	−21.389	1.00	91.83	O
ATOM	5575	NE2	GLN	B	78	40.108	−108.485	−21.171	1.00	85.89	N
ATOM	5576	C	GLN	B	78	42.603	−108.526	−25.459	1.00	70.28	C
ATOM	5577	O	GLN	B	78	43.644	−108.261	−26.057	1.00	67.58	O
ATOM	5578	N	THR	B	79	41.454	−107.886	−25.685	1.00	68.94	N
ATOM	5579	CA	THR	B	79	41.377	−106.656	−26.476	1.00	64.97	C
ATOM	5580	CB	THR	B	79	40.255	−106.710	−27.530	1.00	68.42	C
ATOM	5581	OG1	THR	B	79	39.009	−107.054	−26.907	1.00	65.59	O
ATOM	5582	CG2	THR	B	79	40.568	−107.741	−28.592	1.00	66.84	C
ATOM	5583	C	THR	B	79	41.108	−105.510	−25.514	1.00	63.42	C
ATOM	5584	O	THR	B	79	40.465	−105.720	−24.479	1.00	66.48	O
ATOM	5585	N	GLU	B	80	41.610	−104.318	−25.837	1.00	57.62	N
ATOM	5586	CA	GLU	B	80	41.404	−103.128	−24.999	1.00	59.51	C
ATOM	5587	CB	GLU	B	80	41.955	−101.875	−25.694	1.00	57.98	C
ATOM	5588	CG	GLU	B	80	41.508	−101.731	−27.145	1.00	62.77	C
ATOM	5589	CD	GLU	B	80	41.758	−100.352	−27.741	1.00	67.64	C
ATOM	5590	OE1	GLU	B	80	42.359	−99.487	−27.052	1.00	68.32	O
ATOM	5591	OE2	GLU	B	80	41.348	−100.143	−28.915	1.00	63.81	O
ATOM	5592	C	GLU	B	80	39.917	−102.922	−24.606	1.00	59.50	C
ATOM	5593	O	GLU	B	80	39.578	−102.874	−23.417	1.00	60.55	O
ATOM	5594	N	ALA	B	81	39.043	−102.837	−25.609	1.00	53.52	N
ATOM	5595	CA	ALA	B	81	37.620	−102.582	−25.393	1.00	52.59	C
ATOM	5596	CB	ALA	B	81	37.197	−101.317	−26.122	1.00	48.50	C
ATOM	5597	C	ALA	B	81	36.761	−103.772	−25.822	1.00	49.06	C
ATOM	5598	O	ALA	B	81	37.274	−104.792	−26.265	1.00	50.75	O
ATOM	5599	N	GLY	B	82	35.450	−103.635	−25.663	1.00	47.91	N
ATOM	5600	CA	GLY	B	82	34.538	−104.733	−25.914	1.00	40.65	C
ATOM	5601	C	GLY	B	82	34.511	−105.027	−27.395	1.00	43.29	C
ATOM	5602	O	GLY	B	82	34.985	−104.221	−28.213	1.00	43.04	O
ATOM	5603	N	VAL	B	83	33.959	−106.187	−27.743	1.00	40.31	N
ATOM	5604	CA	VAL	B	83	33.813	−106.549	−29.129	1.00	41.79	C
ATOM	5605	CB	VAL	B	83	34.458	−107.935	−29.456	1.00	43.54	C
ATOM	5606	CG1	VAL	B	83	35.948	−107.951	−29.081	1.00	42.32	C
ATOM	5607	CG2	VAL	B	83	33.762	−109.060	−28.722	1.00	46.85	C
ATOM	5608	C	VAL	B	83	32.326	−106.476	−29.451	1.00	44.91	C
ATOM	5609	O	VAL	B	83	31.513	−107.224	−28.885	1.00	43.60	O
ATOM	5610	N	ALA	B	84	31.967	−105.549	−30.334	1.00	46.77	N
ATOM	5611	CA	ALA	B	84	30.567	−105.402	−30.740	1.00	45.92	C
ATOM	5612	CB	ALA	B	84	30.241	−103.967	−31.108	1.00	40.86	C
ATOM	5613	C	ALA	B	84	30.224	−106.337	−31.886	1.00	50.06	C
ATOM	5614	O	ALA	B	84	29.088	−106.811	−31.965	1.00	48.82	O
ATOM	5615	N	ASP	B	85	31.195	−106.582	−32.778	1.00	49.29	N
ATOM	5616	CA	ASP	B	85	31.018	−107.535	−33.888	1.00	49.35	C
ATOM	5617	CB	ASP	B	85	30.286	−106.887	−35.081	1.00	48.04	C
ATOM	5618	CG	ASP	B	85	29.606	−107.911	−36.003	1.00	49.56	C
ATOM	5619	OD1	ASP	B	85	29.375	−109.078	−35.580	1.00	50.15	O
ATOM	5620	OD2	ASP	B	85	29.288	−107.525	−37.158	1.00	51.07	O
ATOM	5621	C	ASP	B	85	37.349	−108.144	−34.353	1.00	43.41	C
ATOM	5622	O	ASP	B	85	33.414	−107.582	−34.126	1.00	42.50	O
ATOM	5623	N	LEU	B	86	32.239	−109.274	−35.043	1.00	50.43	N
ATOM	5624	CA	LEU	B	86	33.361	−110.118	−35.393	1.00	53.46	C
ATOM	5625	CB	LEU	B	86	33.389	−111.345	−34.476	1.00	52.35	C
ATOM	5626	CG	LEU	B	86	34.793	−111.624	−33.993	1.00	51.68	C
ATOM	5627	CD1	LEU	B	86	35.446	−110.277	−33.742	1.00	53.35	C
ATOM	5628	CD2	LEU	B	86	34.783	−112.475	−32.739	1.00	43.81	C
ATOM	5629	C	LEU	B	86	33.204	−110.531	−36.798	1.00	55.11	C
ATOM	5630	O	LEU	B	86	32.084	−110.739	−37.297	1.00	53.79	O
ATOM	5631	N	THR	B	87	34.337	−110.664	−37.419	1.00	57.19	N
ATOM	5632	CA	THR	B	87	34.341	−111.776	−38.630	1.00	56.20	C
ATOM	5633	CB	THR	B	87	33.781	−111.924	−39.848	1.00	54.78	C
ATOM	5634	OG1	THR	B	87	33.427	−111.970	−40.856	1.00	54.41	O
ATOM	5635	CG2	THR	B	87	34.785	−110.911	−40.396	1.00	53.53	C
ATOM	5636	C	THR	B	87	35.707	−112.336	−38.979	1.00	57.27	C
ATOM	5637	O	THR	B	87	36.743	−111.581	−38.766	1.00	56.85	O
ATOM	5638	N	TRP	B	88	35.683	−113.554	−39.518	1.00	59.12	N
ATOM	5639	CA	TRP	B	88	36.860	−114.185	−40.114	1.00	57.50	C
ATOM	5640	CB	TRP	B	88	36.537	−115.609	−40.564	1.00	51.93	C
ATOM	5641	CG	TRP	B	88	36.580	−116.647	−39.503	1.00	48.77	C
ATOM	5642	CD1	TRP	B	88	35.524	−117.183	−39.033	1.00	47.99	C
ATOM	5643	NE1	TRP	B	88	35.958	−118.269	−38.065	1.00	49.94	N
ATOM	5644	CE2	TRP	B	88	37.315	−118.121	−37.905	1.00	45.78	C
ATOM	5645	CD2	TRP	B	88	37.742	−117.109	−38.796	1.00	46.50	C
ATOM	5646	CE3	TRP	B	88	39.107	−116.172	−38.834	1.00	46.20	C
ATOM	5647	CZ3	TRP	B	88	39.987	−117.430	−37.980	1.00	42.74	C
ATOM	5648	CH2	TRP	B	88	39.535	−118.423	−37.094	1.00	45.00	C
ATOM	5649	CZ2	TRP	B	88	38.205	−118.189	−37.046	1.00	47.93	C
ATOM	5650	C	TRP	B	88	37.265	−113.421	−41.352	1.00	57.69	C
ATOM	5651	O	TRP	B	88	36.410	−113.067	−42.158	1.00	59.83	O
ATOM	5652	N	VAL	B	89	38.561	−113.155	−41.486	1.00	58.41	N
ATOM	5653	CA	VAL	B	89	39.156	−112.157	−42.781	1.00	61.05	C
ATOM	5654	CB	VAL	B	89	40.093	−111.146	−42.730	1.00	60.94	C
ATOM	5655	CG1	VAL	B	89	40.412	−111.178	−44.144	1.00	60.12	C
ATOM	5656	CG2	VAL	B	89	39.474	−110.523	−41.917	1.00	60.45	C
ATOM	5657	C	VAL	B	89	39.976	−114.082	−43.185	1.00	62.90	C
ATOM	5658	O	VAL	B	89	40.966	−114.422	−42.536	1.00	65.92	O
ATOM	5659	N	GLY	B	90	39.560	−114.752	−44.249	1.00	62.93	N
ATOM	5660	CA	GLY	B	90	40.245	−115.955	−44.680	1.00	65.51	C
ATOM	5661	C	GLY	B	90	40.162	−117.030	−43.618	1.00	70.19	C
ATOM	5662	O	GLY	B	90	39.073	−117.117	−43.094	1.00	76.58	O
ATOM	5663	N	AGLU	B	91	41.312	−117.608	−43.284	0.50	67.86	N
ATOM	5664	N	BGLU	B	91	41.308	−117.628	−43.302	0.50	66.02	N
ATOM	5665	CA	AGLU	B	91	41.374	−118.712	−42.331	0.50	68.13	C
ATOM	5666	CA	BGLU	B	91	41.384	−118.730	−42.343	0.50	65.12	C
ATOM	5667	CB	AGLU	B	91	41.990	119.955	−42.991	0.50	70.16	C
ATOM	5668	CB	BGLU	B	91	41.998	−119.981	−43.005	0.50	64.51	C
ATOM	5669	CG	AGLU	B	91	41.696	−120.088	−44.478	0.50	67.57	C
ATOM	5670	CG	BGLU	B	91	41.039	−121.138	−43.289	0.50	59.02	C
ATOM	5671	CD	AGLU	B	91	42.375	−119.605	−45.298	0.50	65.13	C
ATOM	5672	CD	BGLU	B	91	39.804	−120.728	−44.066	0.50	56.64	C
ATOM	5673	OE1	AGLU	B	91	43.499	−118.605	−44.939	0.50	62.09	O
ATOM	5674	OE1	BGLU	B	91	39.795	−120.898	−45.299	0.50	54.80	O
ATOM	5675	OE2	AGLU	B	91	41.787	−118.550	−46.301	0.50	64.70	O
ATOM	5676	OE2	BGLU	B	91	38.839	−120.140	−43.446	0.50	56.26	O
ATOM	5677	C	AGLU	B	91	42.170	−118.340	−41.082	0.50	67.29	C
ATOM	5678	C	BGLU	B	91	42.183	−118.351	−41.092	0.50	65.46	C
ATOM	5679	O	AGLU	B	91	42.133	−119.057	−40.079	0.50	64.27	O
ATOM	5680	O	BGLU	B	91	42.155	−119.074	−40.092	0.50	62.61	O
ATOM	5681	N	ARG	B	92	42.893	−117.125	−41.155	1.00	66.84	N
ATOM	5682	CA	ARG	B	92	43.744	−116.769	−40.049	1.00	67.02	C
ATOM	5683	CB	ARG	B	92	45.215	−116.870	−40.452	1.00	73.16	C
ATOM	5684	CG	ARG	B	92	45.816	−118.258	−40.349	1.00	80.20	C
ATOM	5685	CD	ARG	B	92	47.334	−118.151	−40.278	1.00	87.72	C
ATOM	5686	NE	ARG	B	92	47.975	−119.464	−40.240	1.00	93.30	N
ATOM	5687	CZ	ARG	B	92	48.346	−120.156	−41.316	1.00	92.04	C
ATOM	5688	NH1	ARG	B	92	48.139	−119.667	−42.538	1.00	90.50	N
ATOM	5689	NH2	ARG	B	92	48.924	−121.341	−41.169	1.00	86.09	N
ATOM	5690	C	ARG	B	92	43.452	−115.332	−39.561	1.00	67.73	C
ATOM	5691	O	ARG	B	92	43.964	−114.500	−38.514	1.00	62.28	O
ATOM	5692	N	GLY	B	93	42.654	−114.590	−40.330	1.00	64.44	N
ATOM	5693	CA	GLY	B	93	42.340	−113.202	−40.002	1.00	41.13	C
ATOM	5694	C	GLY	B	93	41.065	−113.072	−39.180	1.00	59.46	C
ATOM	5695	O	GLY	B	93	40.082	−113.787	−39.417	1.00	54.10	O
ATOM	5696	N	ILE	B	94	41.096	−112.166	−38.203	1.00	57.53	N
ATOM	5697	CA	ILE	B	94	39.914	−111.836	−37.389	1.00	54.08	C
ATOM	5698	CB	ILE	B	94	40.043	−112.345	−35.945	1.00	54.86	C
ATOM	5699	CG1	ILE	B	94	40.244	−113.864	−35.944	1.00	55.49	C
ATOM	5700	CD1	ILE	B	94	41.274	−114.323	−34.939	1.00	51.82	C
ATOM	5701	CG2	ILE	B	94	38.802	−111.986	−35.142	1.00	55.06	C
ATOM	5702	C	ILE	B	94	39.689	−110.334	−37.378	1.00	50.67	C
ATOM	5703	O	ILE	B	94	40.533	−109.565	−36.886	1.00	43.90	O
ATOM	5704	N	LEU	B	95	38.551	−109.924	−37.937	1.00	50.80	N
ATOM	5705	CA	LEU	B	95	38.243	−108.503	−38.068	1.00	51.25	C
ATOM	5706	CB	LEU	B	95	37.784	−108.180	−39.488	1.00	44.58	C
ATOM	5707	CG	LEU	B	95	37.586	−106.699	−39.758	1.00	42.82	C
ATOM	5708	CD1	LEU	B	95	38.915	−105.947	−39.730	1.00	42.64	C
ATOM	5709	CD2	LEU	B	95	36.869	106.516	−41.082	1.00	39.58	C
ATOM	5710	C	LEU	B	95	37.215	−108.075	−37.004	1.00	52.47	C
ATOM	5711	O	LEU	B	95	36.124	−108.668	−36.883	1.00	51.94	O
ATOM	5712	N	VAL	B	96	37.586	−107.056	−36.234	1.00	48.50	N
ATOM	5713	CA	VAL	B	96	36.867	−106.727	−34.999	1.00	50.03	C
ATOM	5714	CB	VAL	B	96	37.786	−106.901	−33.769	1.00	49.73	C
ATOM	5715	CG1	VAL	B	96	37.091	−106.470	−32.490	1.00	45.99	C
ATOM	5716	CG2	VAL	B	96	38.236	−108.343	−33.661	1.00	53.02	C
ATOM	5717	C	VAL	B	96	36.257	−105.322	−35.000	1.00	47.30	C
ATOM	5718	O	VAL	B	96	36.947	−104.329	−35.320	1.00	44.51	O
ATOM	5719	N	ALA	B	97	34.963	−105.263	−34.660	1.00	42.46	N
ATOM	5720	CA	ALA	B	97	34.253	−103.995	−34.416	1.00	41.57	C
ATOM	5721	CB	ALA	B	97	32.788	−104.097	−34.846	1.00	42.70	C
ATOM	5722	C	ALA	B	97	34.352	−103.652	−32.927	1.00	41.26	C
ATOM	5723	O	ALA	B	97	33.706	−104.305	−32.078	1.00	41.62	O
ATOM	5724	N	SER	B	98	35.157	−102.045	−32.598	1.00	38.90	N
ATOM	5725	CA	SER	B	98	35.332	−102.311	−31.202	1.00	42.17	C
ATOM	5726	CB	SER	B	98	36.801	−102.119	−30.901	1.00	40.48	C
ATOM	5727	OG	SER	B	98	36.969	−101.528	−29.630	1.00	42.09	O
ATOM	5728	C	SER	B	98	34.535	−101.096	−30.685	1.00	43.84	C
ATOM	5729	O	SER	B	98	34.391	−100.086	−31.390	1.00	43.91	O
ATOM	5730	N	ASP	B	99	34.079	−101.208	−29.432	1.00	41.97	N
ATOM	5731	CA	ASP	B	99	33.619	−100.069	−28.619	1.00	45.30	C
ATOM	5732	CB	ASP	B	99	33.533	−100.483	−27.153	1.00	41.29	C
ATOM	5733	CG	ASP	B	99	32.333	−101.329	−26.860	1.00	40.81	C
ATOM	5734	OD1	ASP	B	99	31.361	−101.222	−27.619	1.00	46.09	O
ATOM	5735	OD2	ASP	B	99	32.333	−102.081	−25.858	1.00	39.83	O
ATOM	5736	C	ASP	B	99	34.507	−98.816	−28.722	1.00	49.99	C
ATOM	5737	O	ASP	B	99	34.004	−97.690	−28.683	1.00	54.23	O
ATOM	5738	N	SER	B	100	35.820	−99.022	−28.856	1.00	49.39	N
ATOM	5739	CA	SER	B	100	36.813	−97.935	−28.826	1.00	49.13	C
ATOM	5740	CB	SER	B	100	38.237	−98.516	−28.766	1.00	52.42	C
ATOM	5741	OG	SER	B	100	38.542	−99.333	−29.903	1.00	55.48	O
ATOM	5742	C	SRR	B	100	36.705	−96.935	−29.981	1.00	49.01	C
ATOM	5743	O	SER	B	100	37.349	−95.876	−29.952	1.00	48.38	O
ATOM	5744	N	GLY	B	101	35.886	−97.263	−30.981	1.00	50.84	N
ATOM	5745	CA	GLY	B	101	35.845	−96.509	−32.244	1.00	51.68	C
ATOM	5746	C	GLY	B	101	36.693	−97.183	−33.317	1.00	50.34	C
ATOM	5747	O	GLY	B	101	36.683	−96.802	−34.507	1.00	45.27	O
ATOM	5748	N	ALA	B	102	37.418	−98.209	−32.891	1.00	51.11	N
ATOM	5749	CA	ALA	B	102	38.379	−98.845	−33.763	1.00	56.19	C
ATOM	5750	CB	ALA	B	102	39.635	−99.242	−32.996	1.00	54.35	C
ATOM	5751	C	ALA	B	102	37.798	−100.038	−34.495	1.00	55.69	C
ATOM	5752	O	ALA	B	102	36.939	−100.781	−33.975	1.00	55.57	O
ATOM	5753	N	VAL	B	103	38.267	−100.185	−35.728	1.00	54.81	N
ATOM	5754	CA	VAL	B	103	38.209	−101.449	−36.424	1.00	52.81	C
ATOM	5755	CB	VAL	B	103	37.888	−101.256	−37.906	1.00	52.16	C
ATOM	5756	CG1	VAL	B	103	37.906	−102.590	−38.632	1.00	55.23	C
ATOM	5757	CG2	VAL	B	103	36.521	−100.624	−38.049	1.00	50.21	C
ATOM	5758	C	VAL	B	103	39.589	−102.344	−36.247	1.00	55.29	C
ATOM	5759	O	VAL	B	103	40.597	−101.381	−36.508	1.00	53.32	O
ATOM	5760	N	GLU	B	104	39.653	−103.272	−35.748	1.00	60.95	N
ATOM	5761	CA	GLU	B	104	40.958	−103.932	−35.677	1.00	60.99	C
ATOM	5762	CB	GLU	B	104	41.505	−103.997	−34.248	1.00	63.20	C
ATOM	5763	CG	GLU	B	104	40.571	−104.575	−33.203	1.00	67.97	C
ATOM	5764	CD	GLU	B	104	40.969	−104.165	−31.793	1.00	71.48	C
ATOM	5765	OE1	GLU	B	104	41.869	−103.311	−31.642	1.00	77.45	O
ATOM	5766	OE2	GLU	B	104	40.379	−104.589	−30.831	1.00	74.06	O
ATOM	5767	C	GLU	B	104	41.033	−105.275	−36.384	1.00	56.46	C
ATOM	5768	O	GLU	B	104	40.064	−106.345	−36.417	1.00	58.51	O
ATOM	5769	N	LEU	B	105	42.193	−105.503	−36.990	1.00	59.13	N
ATOM	5770	CA	LEU	B	105	42.549	−106.785	−37.387	1.00	58.31	C
ATOM	5771	CB	LEU	B	105	43.176	−106.597	−38.966	1.00	55.08	C
ATOM	5772	CG	LEU	B	105	43.569	−107.352	−39.760	1.00	54.00	C
ATOM	5773	CD1	LEU	B	105	47.385	−108.782	−40.024	1.00	46.73	C
ATOM	5774	CD2	LEU	B	105	44.251	−107.454	−41.065	1.00	49.72	C
ATOM	5775	C	LEU	B	105	43.531	−107.501	−36.687	1.00	57.78	C
ATOM	5776	O	LEU	B	105	44.607	−106.572	−36.364	1.00	55.27	O
ATOM	5777	N	TRP	B	106	43.120	−108.592	−36.269	1.00	58.28	N
ATOM	5778	CA	TRP	B	106	43.955	−109.508	−35.512	1.00	64.66	C
ATOM	5779	CB	TRP	B	106	43.216	−110.112	−34.261	1.00	63.89	C
ATOM	5780	CG	TRP	B	106	43.037	−109.951	−33.209	1.00	65.51	C
ATOM	5781	CD1	TRP	B	106	42.125	−108.946	−33.224	1.00	65.38	C
ATOM	5782	NE1	TRP	B	106	42.268	−107.261	−32.112	1.00	68.29	N
ATOM	5783	CE2	TRP	B	106	43.283	−107.751	−31.338	1.00	65.34	C
ATOM	5784	CD2	TRP	B	106	43.800	−108.583	−32.000	1.00	66.87	C
ATOM	5785	CE3	TRP	B	106	44.867	−109.574	−31.416	1.00	66.51	C
ATOM	5786	CZ3	TRP	B	106	45.376	−109.113	−30.199	1.00	68.73	C
ATOM	5787	CH2	TRP	B	106	44.835	−107.979	−29.568	1.00	66.02	C
ATOM	5788	CZ2	TRP	B	106	43.796	−107.286	−30.123	1.00	64.52	C
ATOM	5789	C	TRP	B	106	44.358	−110.775	−36.422	1.00	69.77	C
ATOM	5790	O	TRP	B	106	43.514	−111.147	−37.153	1.00	68.02	O
ATOM	5791	N	GLU	B	107	45.650	−111.101	−36.389	1.00	69.34	N
ATOM	5792	CA	GLU	B	107	46.215	−112.200	−37.187	1.00	75.38	C
ATOM	5793	CB	GLU	B	107	47.551	−111.175	−37.831	1.00	78.57	C
ATOM	5794	CG	GLU	B	107	47.929	−112.109	−39.118	1.00	88.81	C
ATOM	5795	CD	GLU	B	107	47.318	−111.906	−40.382	1.00	92.66	C
ATOM	5796	OE1	GLU	B	107	47.505	−110.693	−40.636	1.00	95.47	O
ATOM	5797	OE2	GLU	B	307	46.665	−112.655	−41.144	1.00	92.03	O
ATOM	5798	C	GLU	B	107	46.402	−113.443	−36.310	1.00	71.05	C
ATOM	5799	O	GLU	B	107	46.779	−113.152	−35.135	1.00	71.02	O
ATOM	5800	N	LEU	B	108	46.118	−114.606	−36.873	1.00	74.21	N
ATOM	5801	CA	LEU	B	108	46.342	−115.853	−36.161	1.00	75.03	C
ATOM	5802	CB	LEU	B	108	45.405	−116.929	−36.700	1.00	69.06	C
ATOM	5803	CG	LEU	B	108	44.970	−118.697	−35.826	1.00	67.07	C
ATOM	5804	CD1	LEU	B	108	44.761	−117.664	−34.389	1.00	68.92	C
ATOM	5805	CD2	LEU	B	108	43.690	−118.687	−36.395	1.00	66.46	C
ATOM	5806	C	LEU	B	108	47.816	−116.792	−36.246	1.00	77.98	C
ATOM	5807	O	LEU	B	108	48.529	−115.954	−37.195	1.00	78.20	O
ATOM	5808	N	ASP	B	109	48.255	−117.624	−35.225	1.00	81.34	N
ATOM	5809	CA	ASP	B	109	49.602	−117.601	−35.137	1.00	83.51	C
ATOM	5810	CB	ASP	B	109	49.676	−118.425	−33.849	1.00	77.06	C
ATOM	5811	CG	ASP	B	109	51.025	−118.167	−33.177	1.00	75.75	C
ATOM	5812	OD1	ASP	B	109	51.907	−117.604	−33.629	1.00	71.99	O
ATOM	5813	OD2	ASP	B	109	51.189	−119.688	−32.168	1.00	76.57	O
ATOM	5814	C	ASP	B	109	49.947	−118.527	−36.309	1.00	87.08	C
ATOM	5815	O	ASP	B	109	49.056	−119.066	−36.982	1.00	88.10	O
ATOM	5816	N	GLU	B	110	51.243	−118.727	−36.537	1.00	93.37	N
ATOM	5817	CA	GLU	B	110	51.708	−119.781	−37.445	1.00	93.19	C
ATOM	5818	C3	GLU	B	110	53.223	−119.672	−37.673	1.00	55.61	C
ATOM	5819	CG	GLU	B	110	53.729	−120.409	−38.908	1.00	104.01	C
ATOM	5820	CD	GLU	B	110	53.310	−119.746	−40.214	1.00	108.41	C
ATOM	5821	OE1	GLU	B	110	53.844	−118.662	−40.539	1.00	105.68	O
ATOM	5822	OE2	GLU	B	110	52.453	−120.316	−40.924	1.00	109.59	O
ATOM	5823	C	GLU	B	110	51.307	−121.173	−36.904	1.00	85.85	C
ATOM	5824	O	GLU	B	110	50.695	−121.976	−37.620	1.00	74.75	O
ATOM	5825	N	ASN	B	111	51.627	−121.431	−35.632	1.00	80.97	N
ATOM	5826	CA	ASN	B	111	51.203	−122.650	−34.937	1.00	80.19	C
ATOM	5827	CB	ASN	B	111	51.920	−122.789	−33.596	1.00	84.20	C
ATOM	5828	CG	ASN	B	111	53.346	−122.285	−33.637	1.00	88.96	C
ATOM	5829	OD1	ASN	B	111	53.603	−121.116	−33.950	1.00	91.63	O
ATOM	5830	ND2	ASN	B	111	54.285	−123.160	−33.303	1.00	86.31	N
ATOM	5831	C	ASN	B	111	49.713	−122.633	−34.659	1.00	77.46	C
ATOM	5832	O	ASN	B	111	49.115	−123.683	−34.392	1.00	74.75	O
ATOM	5833	N	GLU	B	112	49.144	−121.423	−34.715	1.00	77.89	N
ATOM	5834	CA	GLU	B	112	47.735	−121.122	−34.401	1.00	70.23	C
ATOM	5835	CB	GLU	B	112	46.772	−121.931	−35.284	1.00	67.30	C
ATOM	5836	CG	GLU	B	112	46.947	−121.664	−36.770	1.00	64.55	C
ATOM	5837	CD	GLU	B	112	45.829	−122.252	−37.617	1.00	64.45	C
ATOM	5838	OE1	GLU	B	112	45.052	−123.093	−37.107	1.00	57.22	O
ATOM	5839	OE2	GLU	B	112	45.738	−121.868	−38.805	1.00	65.46	O
ATOM	5840	C	GLU	B	112	47.450	−121.307	−32.906	1.00	68.36	C
ATOM	5841	O	GLU	B	112	46.430	−121.898	−32.515	1.00	68.28	O
ATOM	5842	N	THR	B	113	48.369	−120.791	−32.088	1.00	63.09	N
ATOM	5843	CA	THR	B	113	48.350	−120.976	−30.631	1.00	71.03	C
ATOM	5844	CB	THR	B	113	49.520	−121.865	−30.121	1.00	70.56	C
ATOM	5845	OG1	THR	B	113	50.763	−121.384	−30.655	1.00	65.84	O
ATOM	5846	CG2	THR	B	113	49.310	−123.341	−30.501	1.00	70.31	C
ATOM	5847	C	THR	B	113	48.427	−119.637	−29.912	1.00	70.98	C
ATOM	5848	O	THR	B	113	48.414	−119.583	−78.679	1.00	69.74	O
ATOM	5849	N	LEU	B	114	48.552	−118.566	−30.693	1.00	73.88	N
ATOM	5850	CA	LEU	B	114	48.375	117.207	−30.183	1.00	70.79	C
ATOM	5851	CB	LEU	B	114	49.660	−116.650	−29.536	1.00	82.57	C
ATOM	5852	CG	LEU	B	114	50.965	−116.317	−30.260	1.00	83.70	C
ATOM	5853	CD1	LEU	B	114	50.823	−115.041	−31.079	1.00	91.55	C
ATOM	5854	CD2	LEU	B	114	52.084	−116.157	−29.240	1.00	83.00	C
ATOM	5855	C	LEU	B	114	47.757	−116.268	−31.233	1.00	73.23	C
ATOM	5856	O	LEU	B	114	47.735	−116.576	−32.437	1.00	73.81	O
ATOM	5857	N	ILE	B	115	47.218	−115.145	−30.755	1.00	63.30	N
ATOM	5858	CA	ILE	B	115	46.455	−114.212	−31.597	1.00	53.15	C
ATOM	5859	CB	ILE	B	115	44.940	−114.192	−31.233	1.00	53.75	C
ATOM	5860	CG1	ILE	B	115	44.347	−115.606	−31.279	1.00	53.39	C
ATOM	5861	CD1	ILE	B	115	42.905	−115.729	−30.821	1.00	53.73	C
ATOM	5862	CG2	ILE	B	115	44.172	−113.274	−32.174	1.00	53.26	C
ATOM	5863	C	ILE	B	115	47.082	−112.828	−31.482	1.00	53.11	C
ATOM	5864	O	ILE	B	115	47.268	−112.303	−30.379	1.00	43.24	O
ATOM	5865	N	VAL	B	116	47.413	−112.237	−32.620	1.00	41.29	N
ATOM	5866	CA	VAL	B	116	48.282	−111.070	−32.593	1.00	51.68	C
ATOM	5867	CB	VAL	B	116	49.760	−111.461	−32.990	1.00	55.64	C
ATOM	5868	CG1	VAL	B	116	49.834	−112.118	−34.369	1.00	55.29	C
ATOM	5869	CG2	VAL	B	116	50.739	−110.285	−32.865	1.00	53.74	C
ATOM	5870	C	VAL	B	116	47.677	−109.905	−33.374	1.00	52.15	C
ATOM	5871	O	VAL	B	116	47.213	−110.060	−34.511	1.00	52.20	O
ATOM	5872	N	SER	B	117	47.642	−108.742	−32.732	1.00	53.01	N
ATOM	5873	CA	SER	B	117	47.095	−107.552	−33.367	1.00	56.54	C
ATOM	5874	CE	SER	B	117	47.046	−106.361	−32.397	1.00	56.29	C
ATOM	5875	OG	SER	B	117	46.914	−105.124	−33.093	1.00	50.72	O
ATOM	5876	C	SER	B	117	47.946	−107.217	−34.573	1.00	62.07	C
ATOM	5877	O	SER	B	117	49.151	−107.016	−34.437	1.00	59.85	O
ATOM	5878	N	LYS	B	118	47.305	−107.184	−35.742	1.00	67.80	N
ATOM	5879	CA	LYS	B	118	47.933	−106.723	−36.977	1.00	72.01	C
ATOM	5880	CE	LYS	B	118	47.491	−107.587	−38.167	1.00	76.76	C
ATOM	5881	CG	LYS	B	118	48.171	−107.254	−39.497	1.00	91.87	C
ATOM	5882	CD	LYS	B	118	49.680	−107.517	−39.503	1.00	98.52	C
ATOM	5883	CE	LYS	B	118	50.353	−106.915	−40.736	1.00	100.53	C
ATOM	5884	NZ	LYS	B	118	51.827	−107.149	−40.790	1.00	97.24	N
ATOM	5885	C	LYS	B	118	47.698	−105.218	−37.239	1.00	71.92	C
ATOM	5886	O	LYS	B	118	48.640	−104.496	−37.592	1.00	70.46	O
ATOM	5887	N	PHE	B	119	46.454	−104.750	−37.092	1.00	69.86	N
ATOM	5888	CA	PHE	B	119	46.179	−103.296	−37.056	1.00	63.76	C
ATOM	5889	CB	PHE	B	119	46.089	−102.649	−38.461	1.00	61.26	C
ATOM	5890	CG	PHE	B	119	44.788	−102.900	−39.183	1.00	65.11	C
ATOM	5891	CD1	PHE	B	119	43.623	−102.208	−38.830	1.00	60.22	C
ATOM	5892	CE1	PHE	B	119	42.431	−102.448	−39.490	1.00	58.00	C
ATOM	5893	CZ	PHE	B	119	42.386	−103.157	−40.535	1.00	60.05	C
ATOM	5894	CE2	PHE	B	119	43.535	−104.031	−40.914	1.00	60.93	C
ATOM	5895	CD2	PHE	B	119	44.730	−103.103	−40.242	1.00	60.67	C
ATOM	5896	C	PHE	B	119	44.984	−102.903	−36.181	1.00	59.48	C
ATOM	5897	O	PHE	B	119	43.999	−103.650	−36.052	1.00	47.71	O
ATOM	5898	N	CYS	B	120	45.106	−101.719	−35.588	1.00	54.76	N
ATOM	5899	CA	CYS	B	120	44.064	−101.132	−34.762	1.00	55.05	C
ATOM	5900	CB	CYS	B	120	44.473	−101.170	−33.282	1.00	56.57	C
ATOM	5901	SG	CYS	B	120	43.218	−100.644	−32.075	1.00	56.57	S
ATOM	5902	C	CYS	B	120	43.890	−99.706	−35.254	1.00	51.10	C
ATOM	5903	O	CYS	B	120	44.731	−98.844	−34.990	1.00	50.10	O
ATOM	5904	N	LYS	B	121	42.827	−99.459	−36.010	1.00	48.38	N
ATOM	5905	CA	LYS	B	121	42.618	−98.108	−36.546	1.00	53.69	C
ATOM	5906	CB	LYS	B	121	42.481	−98.106	−38.074	1.00	52.78	C
ATOM	5907	CG	LYS	B	121	43.754	−98.420	−38.850	1.00	58.61	C
ATOM	5908	CD	LYS	B	121	44.945	−97.533	−38.514	1.00	55.17	C
ATOM	5909	CE	LYS	B	121	46.198	−98.107	−39.175	1.00	57.69	C
ATOM	5910	NZ	LY5	B	121	47.343	−97.256	−39.225	1.00	57.73	N
ATOM	5911	C	LYS	B	121	41.451	−97.557	−35.892	1.00	56.87	C
ATOM	5912	O	LYS	B	121	40.291	−97.830	−35.880	1.00	50.93	O
ATOM	5915	N	TYR	B	122	41.777	−96.282	−35.350	1.00	58.95	N
ATOM	5914	CA	TYR	B	122	40.790	−95.556	−34.659	1.00	56.16	C
ATOM	5915	CB	TYR	B	122	41.414	−94.649	−33.461	1.00	55.10	C
ATOM	5916	CG	TYR	B	122	41.946	−95.592	−32.400	1.00	59.30	C
ATOM	5917	CD1	TYR	B	122	41.073	−96.518	−31.573	1.00	58.52	C
ATOM	5918	CE1	TYR	B	122	41.561	−97.173	−30.587	1.00	59.96	C
ATOM	5919	CZ	TYR	B	122	42.948	−97.303	−30.413	1.00	63.52	C
ATOM	5920	OH	TYR	B	122	43.459	−98.351	−29.449	1.00	62.44	O
ATOM	5921	CE2	TYR	B	122	43.827	−96.583	−31214	1.00	61.78	C
ATOM	5922	CD2	TYR	B	122	43.325	−95.137	−32.200	1.00	59.48	C
ATOM	5923	C	TYR	B	122	40.186	−94.569	−35.637	1.00	51.78	C
ATOM	5924	O	TYR	B	122	40.628	−93.220	−35.732	1.00	48.27	O
ATOM	5925	N	GLU	B	123	39.172	−94.642	−36.350	1.00	50.95	N
ATOM	5926	CA	GLU	B	123	38.625	−94.305	−37.483	1.00	54.01	C
ATOM	5927	CB	GLU	B	123	38.788	−94.531	−38.753	1.00	56.70	C
ATOM	5928	CG	GLU	B	123	40.105	−94.689	−39.458	1.00	59.72	C
ATOM	5929	CD	GLU	B	123	40.177	−93.296	−40.021	1.00	66.43	C
ATOM	5930	OE1	GLU	B	123	39.182	−92.656	−40.656	1.00	73.64	O
ATOM	5931	OE2	GLU	B	123	41.222	−92.647	−39.822	1.00	66.29	O
ATOM	5932	C	GLU	B	123	37.164	−93.654	−37.325	1.00	50.95	C
ATOM	5933	O	GLU	B	123	36.751	−92.664	−37.945	1.00	43.25	O
ATOM	5934	N	HIS	B	124	36.401	−94.404	−36.523	1.00	50.98	N
ATOM	5935	CA	HIS	B	124	35.011	−94.075	−36.209	1.00	48.95	C
ATOM	5936	CB	HIS	B	124	34.189	−95.340	−36.030	1.00	44.71	C
ATOM	5937	CG	HIS	B	124	33.731	−95.964	−37.315	1.00	48.97	C
ATOM	5938	ND1	HIS	B	124	32.740	−95.411	−38.104	1.00	47.84	N
ATOM	5939	CE1	HIS	B	124	32.532	−96.386	−39.152	1.00	45.52	C
ATOM	5940	NE2	HIS	B	124	33.342	−97.229	−39.068	1.00	49.14	N
ATOM	5941	CD2	HIS	B	124	34.099	−97.118	−37.927	1.00	46.43	C
ATOM	5942	C	HIS	B	124	34.952	−93.234	−34.934	1.00	51.08	C
ATOM	5943	O	HIS	B	124	35.802	−93.374	−34.040	1.00	55.37	O
ATOM	5944	N	ASP	B	125	33.948	−92.367	−34.843	1.00	28.37	N
ATOM	5945	CA	ASP	B	125	33.830	−91.460	−33.697	1.00	28.93	C
ATOM	5946	CB	ASP	B	125	33.236	−90.121	−34.151	1.00	49.49	C
ATOM	5947	CG	ASP	B	125	34.234	−89.266	−34.904	1.00	51.25	C
ATOM	5948	OD1	ASP	B	125	35.403	−89.127	−34.445	1.00	53.89	O
ATOM	5949	OD2	ASP	B	125	33.838	−88.714	−35951	1.00	50.85	O
ATOM	5950	C	ASP	B	125	33.050	−92.033	−32.507	1.00	46.46	C
ATOM	5951	O	ASP	B	123	32.949	−91.401	−31.462	1.00	48.61	O
ATOM	5952	N	ASP	B	126	32.520	−93.239	−32.665	1.00	46.14	N
ATOM	5953	CA	ASP	B	126	31.676	−93.866	−31.652	1.00	46.41	C
ATOM	5954	CB	ASP	B	126	30.203	−93.519	−31.939	1.00	46.11	C
ATOM	5955	CG	ASP	B	126	29.287	−93.612	−30.705	1.00	46.94	C
ATOM	5956	OD1	ASP	B	126	29.527	−94.400	−29.761	1.00	41.40	O
ATOM	5957	OD2	ASP	B	126	28.267	−92.884	−30.708	1.00	50.52	O
ATOM	5958	C	ASP	B	126	31.893	−95.372	−31.781	1.00	47.52	C
ATOM	5959	O	ASP	B	126	32.626	−95.820	−32.664	1.00	48.68	O
ATOM	5960	N	ILE	B	127	31.253	−96.147	−30.911	1.00	42.98	N
ATOM	5961	CA	ILE	B	127	31.255	−97.589	−31.005	1.00	41.68	C
ATOM	5962	CB	ILE	B	127	30.104	−98.193	−30.158	1.00	40.68	C
ATOM	5963	CG1	ILE	B	127	30.317	−97.912	−28.664	1.00	40.95	C
ATOM	5964	CD1	ILE	B	127	29.080	−98.125	−27.802	1.00	37.16	C
ATOM	5965	CG2	ILE	B	127	29.983	−99.685	−30.391	1.00	40.34	C
ATOM	5966	C	ILE	B	127	31.085	−98.034	−32.462	1.00	43.52	C
ATOM	5967	O	ILE	B	127	30.13	−97.612	−33.136	1.00	44.08	O
ATOM	5968	N	VAL	B	128	32.011	−98.876	−320943	1.00	41.21	N
ATOM	5969	CA	VAL	B	128	31.821	−99.595	−34.197	1.00	37.73	C
ATOM	5970	CB	VAL	B	128	33.141	−100.076	−34.826	1.00	40.52	C
ATOM	5971	CG1	VAL	B	128	32.896	−100.614	−36.242	1.00	36.97	C
ATOM	5972	CG2	VAL	B	128	34.187	−98.958	−34.846	1.00	37.98	C
ATOM	5973	C	VAL	B	128	30.953	−100.791	−33.856	1.00	42.83	C
ATOM	5974	O	VAL	B	128	31.312	−101.595	−32.993	1.00	43.17	O
ATOM	5975	N	SER	B	129	29.806	−100.905	−34.525	1.00	43.61	N
ATOM	5976	CA	SER	B	129	28.770	101.858	−34.120	1.00	45.09	C
ATOM	5977	CB	SER	B	129	27.422	−101.136	−34.033	1.00	42.52	C
ATOM	5978	OG	SER	B	129	27.124	−100.568	−35.290	1.00	41.63	O
ATOM	5979	C	SER	B	129	28.629	−103.031	−35.069	1.00	45.97	C
ATOM	5980	O	SER	B	129	78.012	−104.043	−34.723	1.00	47.68	O
ATOM	5981	N	THR	B	130	29.165	−102.887	36.280	1.00	48.86	N
ATOM	5982	CA	THR	B	130	29.051	−103.941	−37.301	1.00	47.09	C
ATOM	5983	CB	THR	B	130	27.693	−103.890	−38.035	1.00	45.69	C
ATOM	5984	OG1	THR	B	130	27.663	−104.884	−39.071	1.00	47.69	O
ATOM	5985	CG2	THR	B	130	27.436	−102.508	−38.626	1.00	41.63	C
ATOM	5986	C	THR	B	130	30.216	−103.928	−38.315	1.00	48.00	C
ATOM	5987	O	THR	B	130	30.688	−102.848	−38.700	1.00	44.51	O
ATOM	5988	N	VAL	B	131	30.675	−105.134	−38.696	1.00	43.77	N
ATOM	5989	CA	VAL	B	131	31.618	−105.335	−39.805	1.00	42.09	C
ATOM	5990	CB	VAL	B	131	33.097	−105.509	−39.356	1.00	38.74	C
ATOM	5991	CG1	VAL	B	131	33.615	−104.244	−38.726	1.00	35.06	C
ATOM	5992	CG2	VAL	B	131	33.273	−106.703	−38.416	1.00	36.71	C
ATOM	5993	C	VAL	B	131	31.246	−106.542	−40.662	1.00	43.96	C
ATOM	5994	O	VAL	B	131	30.689	−107.523	−40.168	1.00	41.95	O
ATOM	5995	N	SER	B	132	31.574	−106.450	−41.947	1.00	45.06	N
ATOM	5996	CA	SER	B	132	31.426	−107.554	−42.883	1.00	49.46	C
ATOM	5997	CB	SER	B	132	30.168	−107.399	−43.723	1.00	48.28	C
ATOM	5998	OG	SER	B	132	29.634	−108.671	−44.034	1.00	54.33	O
ATOM	5999	C	SER	B	132	32.637	−107.546	−43.804	1.00	52.32	C
ATOM	6000	O	SER	B	132	33.179	−106.467	−44.110	1.00	51.62	O
ATOM	6001	N	VAL	B	133	33.071	−108.738	−44.227	1.00	51.06	N
ATOM	6002	CA	VAL	B	133	34.168	−108.837	−45.191	1.00	52.84	C
ATOM	6003	CB	VAL	B	133	35.118	−110.053	−44.982	1.00	54.30	C
ATOM	6004	CG1	VAL	B	133	36.534	−109.693	−45.411	1.00	54.47	C
ATOM	6005	CG2	VAL	B	133	35.139	−110.524	−43.547	1.00	52.45	C
ATOM	6006	C	VAL	B	133	33.548	−108.967	−46.565	1.00	48.96	C
ATOM	6007	O	VAL	B	133	32.621	−109.765	−46.766	1.00	45.51	O
ATOM	6008	N	LEU	B	134	34.072	−108.181	−47.499	1.00	48.68	N
ATOM	6009	CA	LEU	B	134	33.616	−108.117	−48.889	1.00	54.82	C
ATOM	6010	CB	LEU	B	134	33.960	−106.194	−49.584	1.00	54.90	C
ATOM	6011	CG	LEU	B	134	33.160	−105.585	−49.061	1.00	54.13	C
ATOM	6012	CD1	LEU	B	334	33.856	−104.350	−49.311	1.00	50.36	C
ATOM	6013	CD2	LEU	B	134	31.760	−105.577	−49.656	1.00	51.36	C
ATOM	6014	C	LEU	B	134	34.142	−109.169	−49.643	1.00	56.89	C
ATOM	6015	O	LEU	B	134	35.128	−110.195	−49.222	1.00	59.17	O
ATOM	6016	N	SER	B	135	33.467	−109.132	−50.736	1.00	59.13	N
ATOM	6017	CA	SER	B	135	33.615	−111.166	−51.364	1.00	60.73	C
ATOM	6018	CB	SER	B	135	32.712	−111.121	−52.599	1.00	56.47	C
ATOM	6019	OG	SER	B	135	32.997	−110.111	−53.561	1.00	57.62	O
ATOM	6020	C	SER	B	135	35.061	−111.182	−51.678	1.00	58.42	C
ATOM	6021	O	SER	B	135	35.455	−112.105	−51.362	1.00	56.01	O
ATOM	6022	N	SER	B	136	35.845	−110.575	−52.260	1.00	57.69	N
ATOM	6023	CA	SER	B	136	37.247	−110.166	−52.579	1.00	62.44	C
ATOM	6024	CB	SER	8	136	37.958	−109.143	−53.158	1.00	63.02	C
ATOM	6025	OG	SER	B	136	38.527	−108.356	−52.123	1.00	65.44	O
ATOM	6026	C	SER	B	136	38.022	−111.169	−51.357	1.00	62.61	C
ATOM	6027	O	SER	B	136	38.788	−112.429	−51.473	1.00	66.69	O
ATOM	6028	N	GLY	B	137	37.800	−110.125	−50.206	1.00	55.48	N
ATOM	6029	CA	GLY	B	137	38.539	−111.087	−48.974	1.00	47.50	C
ATOM	6030	C	GLY	B	137	39.581	−109.196	−48.716	1.00	49.55	C
ATOM	6031	O	GLY	B	337	40.368	−110.080	−47.762	1.00	45.40	O
ATOM	6032	N	THR	B	338	39.598	−108.171	−49.565	1.00	49.24	N
ATOM	6033	CA	THR	B	138	40.621	−107.122	−49.471	1.00	53.73	C
ATOM	6034	CB	THR	B	138	41.237	−107.632	−50.849	1.00	54.31	C
ATOM	6035	OG1	THR	B	138	40.189	−107.141	−51.786	1.00	53.93	O
ATOM	6036	CG2	THR	B	138	42.044	−108.128	−51.340	1.00	52.84	C
ATOM	6037	C	THR	B	138	40.094	−106.403	−48.899	1.00	60.37	C
ATOM	6038	O	THR	B	138	40.873	−105.690	−48.571	1.00	59.73	O
ATOM	6039	N	GLN	B	138	38.767	−106.505	−48.805	1.00	60.19	N
ATOM	6040	CA	GLN	B	139	38.104	−105.110	−48.280	1.00	58.93	C
ATOM	6041	CB	GLN	B	139	37.533	−104.184	−49.426	1.00	60.43	C
ATOM	6042	CG	GLN	B	139	38.567	−104.017	−50.436	1.00	62.28	C
ATOM	6043	CD	GLN	8	139	37.938	−103.163	−51.581	1.00	62.13	C
ATOM	6044	OE1	GLN	B	139	36.830	−103.179	−52.015	1.00	65.81	O
ATOM	6045	NE2	GLN	B	139	38.637	−102.154	−52.073	1.00	64.61	N
ATOM	6046	C	GLN	B	139	36.996	−105.412	−47.262	1.00	55.88	C
ATOM	6047	O	GLN	B	139	36.443	−106.123	−47.205	1.00	52.09	O
ATOM	6048	N	ALA	B	140	36.673	−104.608	−46.459	1.00	52.32	N
ATOM	6049	CA	ALA	B	140	35.563	−104.124	−45.525	1.00	50.26	C
ATOM	6050	CB	ALA	B	140	36.039	−105.166	−44.186	1.00	49.35	C
ATOM	6051	C	ALA	B	140	34.82	−103.412	−45.342	1.00	48.76	C
ATOM	6052	O	ALA	B	140	35.386	−102.133	−45.508	1.00	46.92	O
ATOM	6053	N	VAL	B	141	33.535	−103.133	−45.017	1.00	52.43	N
ATOM	6054	CA	VAL	B	141	32.678	−102.192	−44.654	1.00	45.01	C
ATOM	6055	CB	VAL	B	141	31.412	−102.103	−45.538	1.00	45.75	C
ATOM	6056	CG1	VAL	B	141	30.82	−103.679	−45.835	1.00	44.54	C
ATOM	6057	CG2	VAL	B	141	30.363	−101.431	−44.876	1.00	48.04	C
ATOM	6058	C	VAL	B	141	32.311	−102.514	−43.175	1.00	40.96	C
ATOM	6059	O	VAL	B	141	31.986	−103.101	−42.697	1.00	40.51	O
ATOM	6060	N	SER	B	142	32.417	−101.404	−42.456	1.00	38.48	N
ATOM	6061	CA	SER	B	142	32.033	−101.326	−41.053	1.00	36.47	C
ATOM	6062	CB	SER	B	142	33.218	−100.126	−40.234	1.00	36.60	C
ATOM	6063	OG	SER	B	142	33.728	−99.627	−40.787	1.00	31.80	O
ATOM	6064	C	SER	B	142	30.887	−100.326	−40.899	1.00	41.75	C
ATOM	6065	O	SER	B	142	30.750	−99.393	−41.723	1.00	38.85	O
ATOM	6066	N	GLY	B	143	30.091	−100.523	−39.838	1.00	44.44	N
ATOM	6067	CA	GLY	B	143	29.039	−99.592	−39.418	1.00	43.04	C
ATOM	6068	C	GLY	B	143	29.236	−99.117	−37.993	1.00	44.12	C
ATOM	6069	O	GLY	B	143	29.619	−99.192	−37.114	1.00	46.75	O
ATOM	6070	N	SER	B	144	28.973	−97.840	−37.751	1.00	46.78	N
ATOM	6071	CA	SER	B	144	29.108	−97.274	−36.395	1.00	47.89	C
ATOM	6072	CB	SER	B	144	30.298	−96.307	−36.368	1.00	45.29	C
ATOM	6073	OG	SER	B	144	30.465	−95.674	−35.109	1.00	46.89	O
ATOM	6074	C	SER	B	144	27.823	−96.578	−35.869	1.00	46.98	C
ATOM	6075	O	SER	B	144	26.939	−96.204	−36.644	1.00	46.40	O
ATOM	6076	N	LYS	B	145	27.739	−96.422	−34.550	1.00	45.97	N
ATOM	6077	CA	LYS	B	145	26.802	−95.489	−33.927	1.00	46.69	C
ATOM	6078	CB	LYS	B	145	26.820	−95.606	−32.402	1.00	45.76	C
ATOM	6079	CD	LYS	B	145	26.431	−96.986	−31.891	1.00	47.74	C
ATOM	6080	CD	LYS	B	145	25.876	−96.941	−30.473	1.00	46.93	C
ATOM	6081	CE	LYS	B	145	25.606	−98.336	−29.919	1.00	46.68	C
ATOM	6082	NZ	LYS	B	145	24.527	−99.041	−30.668	1.00	50.60	N
ATOM	6083	C	LYS	B	145	27.057	−94.036	−34.349	1.00	47.05	C
ATOM	6084	O	LYS	B	145	26.179	−93.184	−34.174	1.00	51.38	O
ATOM	6085	N	ASP	B	146	28.235	−93.760	−34.920	1.00	43.73	N
ATOM	6086	CA	ASP	B	146	28.580	−92.414	−35.400	1.00	43.09	C
ATOM	6087	CB	ASP	B	146	30.108	−92.212	−35.473	1.00	48.38	C
ATOM	6088	CG	ASP	B	146	30.755	−92.842	−36.716	1.00	46.54	C
ATOM	6089	OD1	ASP	B	146	30.141	−93.668	−37.428	1.00	42.69	O
ATOM	6090	OD2	ASP	B	146	31.913	−92.484	−36.978	1.00	51.98	O
ATOM	6091	C	ASP	B	146	27.919	−92.094	−36.748	1.00	44.51	C
ATOM	6092	O	ASP	B	146	28.215	−91.065	−37.376	1.00	40.46	O
ATOM	6093	N	ILE	B	147	27.023	−92.996	−37.365	1.00	43.50	N
ATOM	6094	CA	ILE	B	147	26.183	−92.866	−38.363	1.00	44.54	C
ATOM	6095	CB	ILE	B	147	25.351	−91.553	−38.339	1.00	43.56	C
ATOM	6096	CG1	ILE	B	147	24.704	−91.388	−36.951	1.00	45.02	C
ATOM	6097	CD1	ILE	B	147	24.160	−89.994	−36.637	1.00	38.58	C
ATOM	6098	CG2	ILE	B	147	24.261	−91.584	−39.406	1.00	42.12	C
ATOM	6099	C	ILE	B	147	26.945	−93.137	−39.696	1.00	46.06	C
ATOM	6100	O	ILE	B	147	26.347	−93.178	−40.772	1.00	43.95	O
ATOM	6101	N	CYS	B	148	28.259	−93.363	−39.609	1.00	50.83	N
ATOM	0102	CA	CYS	B	148	29.087	−95.656	−40.799	1.00	47.32	C
ATOM	6103	CB	CYS	B	148	30.450	−92.968	−40.666	1.00	47.77	C
ATOM	6104	SG	CYS	B	148	30.257	−91.178	−40.611	1.00	54.93	S
ATOM	6105	C	CYS	B	148	29.225	−95.110	−41.180	1.00	45.70	C
ATOM	6106	O	CYS	B	148	28.991	−96.006	−40.370	1.00	52.38	O
ATOM	6107	N	ILE	B	149	29.563	−95.333	−42.446	1.00	45.22	N
ATOM	6108	CA	ILE	B	149	29.784	−96.643	−43.038	1.00	41.76	C
ATOM	6109	CB	ILE	B	149	28.638	−97.038	−43.986	1.00	40.55	C
ATOM	6110	CG1	ILE	B	149	27.402	−97.430	−43.185	1.00	43.10	C
ATOM	6111	CD1	ILE	B	149	26.156	−97.752	−44.014	1.00	42.94	C
ATOM	6112	CG2	ILE	B	149	29.026	−98.215	−44.862	1.00	41.80	C
ATOM	6113	C	ILE	B	149	31.084	−96.441	−43.795	1.00	45.49	C
ATOM	6114	O	ILE	B	149	31.242	−95.436	−44.491	1.00	41.71	O
ATOM	6115	N	LYS	B	150	32.044	−97.348	−43.601	1.00	49.26	N
ATOM	6116	CA	LYS	B	150	33.407	−97.131	−44.108	1.00	43.72	C
ATOM	6117	CB	LYS	B	150	34.369	−96.788	−42.967	1.00	43.39	C
ATOM	6118	CG	LYS	B	150	34.202	−95.404	−42.377	1.00	43.07	C
ATOM	6119	CD	LYS	B	150	35.273	−95.143	−41.333	1.00	44.63	C
ATOM	6120	CE	LYS	B	150	34.890	−94.024	−40.382	1.00	41.66	C
ATOM	6121	NZ	LYS	B	150	35.047	−92.686	−41.006	1.00	41.75	N
ATOM	6122	C	LYS	B	150	33.942	−98.328	−44.880	1.00	40.53	C
ATOM	6123	O	LYS	B	150	33.746	−99.459	−44.482	1.00	48.04	O
ATOM	6124	N	VAL	B	151	34.620	−98.066	−45.988	1.00	50.84	N
ATOM	6125	CA	VAL	B	151	35.180	−99.150	−46.793	1.00	51.76	C
ATOM	6126	CB	VAL	B	151	34.811	−99.007	−48.280	1.00	57.68	C
ATOM	6127	CG1	VAL	B	151	35.560	−100.037	−49.116	1.00	60.72	C
ATOM	6128	CG2	VAL	B	151	33.307	−99.174	−48.461	1.00	54.29	C
ATOM	6129	C	VAL	B	151	36.692	−99.263	−46.584	1.00	54.46	C
ATOM	6130	O	VAL	B	151	37.446	−98.300	−46.760	1.00	52.05	O
ATOM	6131	N	TRP	B	152	37.119	−100.451	−46.191	1.00	54.80	N
ATOM	6132	CA	TRP	B	152	38.498	−100.665	−45.785	1.00	61.73	C
ATOM	6133	CB	TRP	B	152	38.511	−101.452	−44.481	1.00	60.43	C
ATOM	6134	CG	TRP	B	152	37.952	−100.694	−43.328	1.00	61.25	C
ATOM	6135	CD1	TRP	B	152	36.638	−100.596	−42.963	1.00	60.17	C
ATOM	6136	NE1	TRP	B	152	36.516	−99.815	−41.841	1.00	60.54	N
ATOM	6137	CE2	TRP	B	152	37.762	−99.391	−41.458	1.00	63.82	C
ATOM	6138	CD2	TRP	B	152	38.692	−99.923	−42.379	1.00	62.04	C
ATOM	6139	CE3	TRP	B	152	40.055	−99.640	−42.208	1.00	60.02	C
ATOM	6140	CZ3	TRP	B	152	40.441	−98.841	−41.137	1.00	61.80	C
ATOM	6141	CH2	TRP	B	152	39.491	−98.322	−40.239	1.00	62.30	C
ATOM	6142	CZ2	TRP	B	152	38.152	−98.583	−40.381	1.00	62.33	C
ATOM	6143	C	TRP	B	152	39.320	−101.416	−46.825	1.00	61.60	C
ATOM	6144	O	TRP	B	152	38.827	−102.369	−47.435	1.00	62.66	O
ATOM	6145	N	ASP	B	153	40.561	−100.973	−47.022	1.00	62.63	N
ATOM	6146	CA	ASP	B	153	41.602	−101.788	−47.669	1.00	65.57	C
ATOM	6147	CB	ASP	B	153	42.548	−100.910	−48.494	1.00	74.26	C
ATOM	6148	CG	ASP	B	153	43.431	−101.718	−49.447	1.00	81.30	C
ATOM	6149	OD1	ASP	B	153	43.566	−102.950	−49.268	1.00	80.65	O
ATOM	6150	OD2	ASP	B	153	43.994	−101.106	−50.383	1.00	81.57	O
ATOM	6151	C	ASP	B	153	42.403	−102.540	−46.595	1.00	59.52	C
ATOM	6152	O	ASP	B	153	43.207	−101.937	−45.867	1.00	53.43	O
ATOM	6153	N	LEU	B	154	42.177	−103.850	−46.497	1.00	56.41	N
ATOM	6154	CA	LEU	B	154	42.777	−104.659	−45.415	1.00	58.59	C
ATOM	6155	CB	LEU	B	154	42.110	−106.023	−45.303	1.00	52.80	C
ATOM	6156	CG	LEU	B	154	40.614	−105.884	−45.027	1.00	52.72	C
ATOM	6157	CD1	LEU	B	154	39.918	−157.219	−45.234	1.00	50.38	C
ATOM	6158	CD2	LEU	B	154	40.371	−105.313	−43.626	1.00	51.68	C
ATOM	6159	C	LEU	B	154	44.277	−104.837	−45.547	1.00	64.03	C
ATOM	6160	O	LEU	B	154	44.991	−104.856	−44.539	1.00	62.46	O
ATOM	6161	N	ALA	B	155	44.738	−104.975	−46.792	1.00	63.98	N
ATOM	6162	CA	ALA	B	155	46.159	−105.010	−47.090	1.00	63.87	C
ATOM	6163	CB	ALA	B	155	46.391	−105.538	−48.562	1.00	63.13	C
ATOM	6164	C	ALA	B	155	46.800	−103.675	−46.715	1.00	60.36	C
ATOM	6165	O	ALA	B	155	47.812	−103.649	−46.021	1.00	58.65	O
ATOM	6166	N	GLN	B	156	46.198	−102.570	−47.152	1.00	62.37	N
ATOM	6167	CA	GLN	B	156	46.770	−101.245	−46.896	1.00	65.31	C
ATOM	6168	CB	GLN	B	156	46.335	−100.234	−47.973	1.00	68.55	C
ATOM	6169	CG	GLN	B	156	47.229	−100.209	−49.209	1.00	73.69	C
ATOM	6170	CD	GLN	B	156	48.703	−99.995	−48.866	1.00	73.90	C
ATOM	6171	OE1	GLN	B	156	49.112	−98.893	−48.491	1.00	69.89	O
ATOM	6172	NE2	GLN	B	156	49.504	−101.657	−48.986	1.00	72.34	N
ATOM	6173	C	GLN	B	156	46.520	−100.682	−45.488	1.00	64.49	C
ATOM	6174	O	GLN	B	156	47.181	−99.721	−45.082	1.00	62.29	O
ATOM	6175	N	GLN	B	157	45.580	−101.277	−44.746	1.00	64.31	N
ATOM	6176	CA	GLN	B	157	45.206	−100.773	−43.414	1.00	63.92	C
ATOM	6177	CB	GLN	B	157	46.379	−100.898	−42.431	1.00	65.04	C
ATOM	6178	CG	GLN	B	157	47.063	−102.263	−42.436	1.00	62.42	C
ATOM	6179	CD	GLN	B	157	48.124	−102.384	−41.363	1.00	57.86	C
ATOM	6180	OE1	GLN	B	157	48.578	−101.384	−40.800	1.00	55.85	O
ATOM	6181	NE2	GLN	B	157	48.522	−103.613	−41.069	1.00	57.89	N
ATOM	6182	C	GLN	B	157	44.717	−99.310	−43.469	1.00	63.11	C
ATOM	6183	O	GLN	B	157	45.123	−98.474	−42.648	1.00	64.49	O
ATOM	6184	N	VAL	B	158	43.878	−99.101	−44.459	1.00	56.09	N
ATOM	6185	CA	VAL	B	158	43.271	−97.681	−44.558	1.00	54.26	C
ATOM	6186	CB	VAL	B	158	44.046	−96.721	−45.508	1.00	53.74	C
ATOM	6187	CG1	VAL	B	158	45.333	−96.201	−44.872	1.00	51.59	C
ATOM	6188	CG2	VAL	B	158	44.279	−97.359	−46.867	1.00	50.43	C
ATOM	6189	C	VAL	B	158	41.797	−97.703	−44.978	1.00	52.41	C
ATOM	6190	O	VAL	B	158	41.304	−98.677	−45.563	1.00	50.30	O
ATOM	6191	N	VAL	B	159	41.124	−96.594	−44.679	1.00	53.74	N
ATOM	6192	CA	VAL	B	159	39.772	−96.302	−45.153	1.00	52.48	C
ATOM	6193	CB	VAL	B	159	39.078	−95.240	−44.259	1.00	50.72	C
ATOM	6194	CG1	VAL	B	159	37.690	−94.879	−44.794	1.00	48.98	C
ATOM	6195	CG2	VAL	B	159	38.993	−95.719	−42.818	1.00	51.43	C
ATOM	6196	C	VAL	B	159	39.873	−95.728	−46.554	1.00	53.78	C
ATOM	6197	O	VAL	B	159	40.491	−94.677	−46.748	1.00	54.13	O
ATOM	6198	N	LEU	B	160	39.256	−96.408	−47.519	1.00	54.53	N
ATOM	6199	CA	LEU	B	160	39.197	−95.915	−48.895	1.00	58.93	C
ATOM	6200	CB	LEU	B	160	39.090	−97.078	−49.894	1.00	57.12	C
ATOM	6201	CG	LEU	B	160	40.119	−98.215	−49.818	1.00	59.31	C
ATOM	6202	CD1	LEU	B	160	39.488	−99.544	−50.195	1.00	57.74	C
ATOM	6203	CD2	LEU	B	160	41.364	−97.949	−50.657	1.00	59.81	C
ATOM	6204	C	LEU	B	160	38.013	−94.958	−49.058	1.00	63.48	C
ATOM	6205	O	LEU	B	160	38.169	−93.844	−49.571	1.00	65.59	O
ATOM	6206	N	SER	B	161	36.841	−95.400	−48.604	1.00	64.09	N
ATOM	6207	CA	SER	B	161	35.602	−94.634	−48.713	1.00	62.49	C
ATOM	6208	CB	SER	B	161	34.682	−95.286	−49.735	1.00	63.66	C
ATOM	6209	OG	SER	B	161	35.126	−95.027	−51.047	1.00	70.60	O
ATOM	6210	C	SER	B	161	34.859	−94.512	−47.381	1.00	63.00	C
ATOM	6211	O	SER	B	161	34.755	−95.480	−46.619	1.00	63.09	O
ATOM	6212	N	SER	B	162	34.339	−93.315	−47.124	1.00	58.54	N
ATOM	6213	CA	SER	B	162	33.573	−93.019	−45.925	1.00	54.52	C
ATOM	6214	CB	SER	B	162	34.348	−92.030	−45.072	1.00	55.15	C
ATOM	6215	OG	SER	B	162	33.851	−92.024	−43.753	1.00	59.41	O
ATOM	6216	C	SER	B	162	32.210	−92.432	−46.324	1.00	55.16	C
ATOM	6217	O	SER	B	162	32.153	−91.405	−47.005	1.00	52.93	O
ATOM	6218	N	TYR	B	163	31.124	−93.090	−45.912	1.00	51.82	N
ATOM	6219	CA	TYR	B	163	29.769	−92.704	−46.311	1.00	52.43	C
ATOM	6220	CB	TYR	B	163	29.125	−93.814	−47.140	1.00	57.72	C
ATOM	6221	CG	TYR	B	163	29.906	−94.248	−48.357	1.00	65.81	C
ATOM	6222	CD1	TYR	B	163	30.048	−93.405	−49.459	1.00	67.45	C
ATOM	6223	CE1	TYR	B	163	30.759	−93.809	−50.581	1.00	72.41	C
ATOM	6224	CZ	TYR	B	163	31.332	−95.076	−50.616	1.00	75.73	C
ATOM	6225	OH	TYR	B	163	32.047	−95.485	−51.729	1.00	77.61	O
ATOM	6226	CE2	TYR	B	163	31.194	−95.930	−49.534	1.00	71.82	C
ATOM	6227	CD2	TYR	B	163	30.483	−95.516	−48.417	1.00	68.74	C
ATOM	6228	C	TYR	B	163	28.823	−92.366	−45.143	1.00	54.27	C
ATOM	6229	O	TYR	B	163	28.523	−93.220	−44.299	1.00	53.21	O
ATOM	6230	N	ARG	B	164	28.338	−91.123	−45.115	1.00	53.72	N
ATOM	6231	CA	ARG	B	164	27.251	−90.715	−44.223	1.00	51.32	C
ATOM	6232	CB	ARG	B	164	27.447	−89.280	−43.762	1.00	56.01	C
ATOM	6233	CG	ARG	B	164	27.999	−89.136	−42.371	1.00	63.23	C
ATOM	6234	CD	ARG	B	164	27.957	−87.686	−41.928	1.00	66.12	C
ATOM	6235	NE	ARG	B	164	26.930	−87.461	−40.921	1.00	69.62	N
ATOM	6236	CZ	ARG	B	164	27.072	−87.734	−39.620	1.00	73.84	C
ATOM	6237	NH1	ARG	B	164	28.205	−88.262	−39.158	1.00	69.44	N
ATOM	6238	NH2	ARG	B	164	26.071	−87.485	−38.777	1.00	68.43	N
ATOM	6239	C	ARG	B	164	25.919	−90.795	−44.944	1.00	48.59	C
ATOM	6240	O	ARG	B	164	25.333	−89.772	−45.278	1.00	49.51	O
ATOM	6241	N	ALA	B	165	25.438	−91.999	−45.202	1.00	47.62	N
ATOM	6242	CA	ALA	B	165	24.182	−92.140	−45.919	1.00	48.24	C
ATOM	6243	CB	ALA	B	165	24.125	−93.472	−46.640	1.00	47.18	C
ATOM	6244	C	ALA	B	165	23.019	−92.012	−44.958	1.00	45.75	C
ATOM	6245	O	ALA	B	165	21.974	−91.469	−45.301	1.00	49.86	O
ATOM	6246	N	HIS	B	166	23.234	−92.502	−43.746	1.00	44.18	N
ATOM	6247	CA	HIS	B	166	22.179	−92.673	−42.777	1.00	45.25	C
ATOM	6248	CB	HIS	B	166	22.488	−93.888	−41.925	1.00	45.90	C
ATOM	6249	CG	HIS	B	166	22.209	−95.182	−42.611	1.00	45.12	C
ATOM	6250	ND1	HIS	B	166	20.930	−95.598	−42.916	1.00	44.43	N
ATOM	6251	CE1	HIS	B	166	20.986	−96.780	−43.499	1.00	41.52	C
ATOM	6252	NE2	HIS	B	166	22.255	−97.146	−43.579	1.00	43.05	N
ATOM	6253	CD2	HIS	B	166	23.038	−96.166	−43.028	1.00	43.04	C
ATOM	6254	C	HIS	B	166	21.940	−91.455	−41.893	1.00	45.31	C
ATOM	6255	O	HIS	B	166	22.728	−90.509	−41.908	1.00	43.18	O
ATOM	6256	N	ALA	B	167	20.844	−91.472	−41.132	1.00	45.64	N
ATOM	6257	CA	ALA	B	167	20.558	−90.335	−40.249	1.00	51.66	C
ATOM	6258	CB	ALA	B	167	19.399	−89.498	−40.779	1.00	43.78	C
ATOM	6259	C	ALA	B	167	20.383	−90.716	−38.766	100	52.81	C
ATOM	6260	O	ALA	B	167	20.002	−89.895	−37.918	1.00	53.10	O
ATOM	6261	N	ALA	B	168	20.695	−91.975	−38.483	1.00	48.67	N
ATOM	6262	CA	ALA	B	168	20.783	−92.492	−37.133	100	49.49	C
ATOM	6263	CB	ALA	B	168	19.435	−93.021	−36.680	1.00	47.49	C
ATOM	6264	C	ALA	B	168	21.836	−93.606	−37.138	1.00	49.98	C
ATOM	6265	O	ALA	B	168	22.244	−94.076	−38.198	1.00	53.91	O
ATOM	6266	N	GLN	B	169	22.281	−94.014	−35.957	1.00	46.69	N
ATOM	6267	CA	GLN	B	169	23.323	−95.022	−35.819	1.00	45.50	C
ATOM	6268	CB	GLN	B	169	23.483	−95.416	−34.351	1.00	43.61	C
ATOM	6269	CG	GLN	B	169	22.165	−95.636	−33.641	1.00	43.43	C
ATOM	6270	CD	GLN	B	169	22.321	−96.272	−32.275	1.00	48.75	C
ATOM	6271	OE1	GLN	B	169	22.054	−97.472	−32.110	1.00	47.39	O
ATOM	6272	NE2	GLN	B	169	22.751	−95.480	−31.284	1.00	42.54	N
ATOM	6273	C	GLN	B	169	23.056	−96.149	−36.697	1.00	44.90	C
ATOM	6274	O	GLN	B	169	21.906	−96.631	−36.919	1.00	41.94	O
ATOM	6225	N	VAL	B	170	24.136	−96.137	−37.206	1.00	45.70	N
ATOM	6276	CA	VAL	B	170	24.067	−97.994	−38.119	1.00	47.01	C
ATOM	6227	CB	VAL	B	170	25.281	−98.054	−39.068	1.00	46.19	C
ATOM	6278	CG1	VAL	B	170	25.017	−99.082	−40.156	1.00	45.48	C
ATOM	6279	CG2	VAL	B	170	25.600	−96.679	−39.667	1.00	42.20	C
ATOM	6280	C	VAL	B	170	23.992	−99.314	−37.357	1.00	44.86	C
ATOM	6281	O	VAL	B	170	24.732	−99.526	−36.405	1.00	45.97	O
ATOM	6282	N	THR	B	171	23.116	−100.208	−37.794	1.00	43.83	N
ATOM	6283	CA	THR	B	171	22.775	−101.388	−37.006	1.00	43.63	C
ATOM	6284	CB	THR	B	171	21.230	−101.561	−36.927	1.00	42.60	C
ATOM	6285	DG1	THR	B	171	20.629	−100.335	−36.492	1.00	48.40	O
ATOM	6286	CG2	THR	B	171	20.792	−102.694	−35.975	1.00	38.40	C
ATOM	6287	C	THR	B	171	23.460	−102.635	−37.571	1.00	48.79	C
ATOM	6288	O	THR	B	171	24.010	−103.432	−36.810	1.00	50.35	O
ATOM	6289	N	ACYS	B	172	23.406	−102.817	−38.897	0.50	49.19	N
ATOM	6290	N	BCYS	B	172	23.418	−102.771	−38.896	0.50	53.08	N
ATOM	6291	CA	ACYS	B	172	23.991	−103.990	−39.582	0.50	48.96	C
ATOM	6292	CA	BCYS	B	172	24.018	−103.891	−39.605	0.50	55.75	C
ATOM	6293	CB	ACYS	B	172	22.944	−105.111	−39.753	0.50	46.57	C
ATOM	6294	CB	BCYS	B	172	22.955	−104.922	−39.984	0.50	58.09	C
ATOM	6295	SG	ACYS	B	172	23.528	−106.712	−40.412	0.50	40.87	S
ATOM	6296	SG	BCYS	B	172	21.895	−105.481	−38.639	0.50	66.01	S
ATOM	6297	C	ACYS	B	172	24.524	−103.600	−40.952	0.50	50.55	C
ATOM	6298	C	BCYS	B	172	24.653	−103.410	−40.887	0.50	54.70	C
ATOM	6299	O	ACYS	B	172	23.863	−102.860	−41.689	0.50	49.76	O
ATOM	6300	O	BCYS	B	172	24.185	−102.447	−41.500	0.50	54.67	O
ATOM	6301	N	VAL	B	173	25.715	−104.096	−41.291	1.00	52.27	N
ATOM	6302	CA	VAL	B	173	26.202	−104.032	−42.678	1.00	48.77	C
ATOM	6303	CB	VAL	B	173	27.393	−103.054	−42.913	1.00	47.41	C
ATOM	6304	CG1	VAL	B	173	20.952	−101.616	−42.735	1.00	43.70	C
ATOM	6305	CG2	VAL	B	173	28.622	−103.384	−42.059	1.00	47.25	C
ATOM	6306	C	VAL	B	173	26.543	−105.440	−43.148	1.00	50.27	C
ATOM	6307	O	VAL	B	173	27.306	−106.134	−42.480	1.00	53.11	O
ATOM	6308	N	ALA	B	174	25.975	−105.861	−44.282	1.00	52.47	N
ATOM	6309	CA	ALA	B	174	26.292	−107.177	−44.881	1.00	53.02	C
ATOM	6310	CB	ALA	B	174	25.102	−108.120	−44.764	1.00	52.34	C
ATOM	6311	C	ALA	B	174	26.777	−107.124	−46.336	1.00	50.54	C
ATOM	6312	O	ALA	B	174	26.060	−106.641	−47.209	1.00	51.12	O
ATOM	6313	N	ALA	B	175	27.987	−107.646	−46.583	1.00	50.28	N
ATOM	6314	CA	ALA	B	175	28.581	−107.745	−47.941	1.00	45.14	C
ATOM	6315	CB	ALA	B	175	30.049	−108.136	−47.844	1.00	45.69	C
ATOM	6316	C	ALA	B	175	27.828	−108.757	−48.792	1.00	44.90	C
ATOM	6317	O	ALA	B	175	27.452	−109.818	−48.294	1.00	44.56	O
ATOM	6318	N	SER	B	176	27.583	−108.446	−50.067	1.00	47.56	N
ATOM	6319	CA	SER	B	176	26.955	−109.452	−50.960	1.00	47.57	C
ATOM	6320	CB	SER	B	176	26.675	−108.501	−52.359	1.00	45.92	C
ATOM	6321	OG	SER	B	176	27.878	−108.659	−53.045	1.00	50.75	O
ATOM	6322	C	SER	B	176	27.850	−110.684	−51.049	1.00	46.08	C
ATOM	6323	O	SER	B	176	29.064	−110.568	−50.870	1.00	44.08	O
ATOM	6324	N	PRO	B	177	27.253	−111.868	−51.294	1.00	49.69	N
ATOM	6325	CA	PRO	B	177	28.056	−113.097	−51.350	1.00	49.07	C
ATOM	6326	CB	PRO	B	177	27.035	−114.182	−51.712	1.00	47.99	C
ATOM	6327	CG	PRO	B	177	25.710	−113.621	−51.282	1.00	49.71	C
ATOM	6328	CD	PRO	B	177	25.817	−112.137	−51.523	1.00	46.58	C
ATOM	6329	C	PRO	B	177	29.156	−113.030	−52.411	1.00	53.54	C
ATOM	6330	O	PRO	B	177	30.275	−113.488	−52.142	1.00	53.83	O
ATOM	6331	N	HIS	B	178	28.866	−112.423	−53.570	1.00	52.06	N
ATOM	6332	CA	HIS	B	178	29.797	−112.483	−54.710	1.00	52.50	C
ATOM	6333	CB	HIS	B	178	29.238	−113.416	−55.798	1.00	50.65	C
ATOM	6334	CG	HIS	B	178	28.867	−114.776	−55.287	1.00	53.28	C
ATOM	6335	ND1	HIS	B	178	29.785	−115.626	−54.692	1.00	52.11	N
ATOM	6336	CE1	HIS	B	178	29.176	−116.742	−54.331	1.00	51.67	C
ATOM	6337	NE2	HIS	B	178	27.900	−116.652	−54.673	1.00	54.90	N
ATOM	6338	CD2	HIS	B	178	27.679	−115.430	−55.269	1.00	50.81	C
ATOM	6339	C	HIS	B	178	30.301	−111.184	−55.356	1.00	52.53	C
ATOM	6340	O	HIS	B	178	31.102	−111.265	−56.287	1.00	52.60	O
ATOM	6341	N	LYS	B	179	29.858	−110.010	−54.892	1.00	49.84	N
ATOM	6342	CA	LYS	B	179	30.275	−108.735	−55.522	1.00	48.91	C
ATOM	6343	CB	LYS	B	179	29.096	−108.044	−56.211	1.00	49.15	C
ATOM	6344	CG	LYS	B	179	28.364	−108.894	−57.232	1.00	51.10	C
ATOM	6345	CD	LYS	B	179	27.227	−108.107	−57.872	1.00	58.82	C
ATOM	6346	CE	LYS	B	179	26.029	−108.994	−58.184	1.00	59.99	C
ATOM	6347	NZ	LYS	B	179	25.014	−108.272	−58.997	1.00	65.72	N
ATOM	6348	C	LYS	B	179	30.926	−107.773	−54.546	1.00	49.84	C
ATOM	6349	O	LYS	B	179	30.287	−107.313	−53.589	1.00	49.87	O
ATOM	6350	N	ASP	B	180	32.195	−107.464	−54.796	1.00	54.50	N
ATOM	6351	CA	ASP	B	180	33.024	−106.639	−53.886	1.00	59.15	C
ATOM	6352	CB	ASP	B	180	34.449	−106.479	−54.448	1.00	66.77	C
ATOM	6353	CG	ASP	B	180	35.519	−107.178	−53.604	1.00	70.73	C
ATOM	6354	OD1	ASP	B	180	35.238	−108.223	52.076	1.00	66.36	O
ATOM	6355	OD2	ASP	B	180	36.666	−106.668	−53.586	1.00	77.89	O
ATOM	6356	C	ASP	B	180	32.473	−105.241	−53.603	1.00	58.47	C
ATOM	6357	O	ASP	B	180	32.892	−104.585	−52.647	1.00	64.72	O
ATOM	6358	N	SER	B	181	31.549	−104.785	−54.442	1.00	53.04	N
ATOM	6359	CA	SER	B	181	31.110	−103.407	−54.412	1.00	48.52	C
ATOM	6360	CB	SER	B	181	31.335	−102.786	−55.787	1.00	49.90	C
ATOM	6361	OG	SER	B	181	30.420	−103.340	−56.715	1.00	53.21	O
ATOM	6362	C	SER	B	181	29.642	−103.299	−54.040	1.00	45.71	C
ATOM	6363	O	SER	B	181	29.067	−102.220	−54.101	1.00	46.22	O
ATOM	6364	N	VAL	B	182	29.037	−104.426	−53.689	1.00	43.92	N
ATOM	6365	CA	VAL	B	182	27.641	−104.470	−53.283	1.00	44.43	C
ATOM	6366	CB	VAL	B	182	26.792	−105.316	−54.257	1.00	44.94	C
ATOM	6367	CG1	VAL	B	182	25.363	−105.523	−53.747	1.00	44.93	C
ATOM	6368	CG2	VAL	B	182	26.765	−104.663	−55.626	1.00	46.16	C
ATOM	6369	C	VAL	B	182	27.520	−105.006	−51.862	1.00	46.65	C
ATOM	6370	O	VAL	B	182	28.048	−106.073	−51.540	1.00	49.07	O
ATOM	6371	N	PHE	B	183	26.829	−104.244	−51.017	1.00	50.34	N
ATOM	6372	CA	PHE	B	183	26.508	−104.658	−49.641	1.00	49.09	C
ATOM	6373	CB	PHE	B	183	27.672	−104.353	−48.698	1.00	46.11	C
ATOM	6374	CG	PHE	B	183	28.117	−102.920	−48.714	1.00	46.94	C
ATOM	6375	CD1	PHE	B	183	27.456	−101.958	−47.948	1.00	48.29	C
ATOM	6376	CE1	PHE	B	183	27.878	−100.642	−47.945	1.00	45.01	C
ATOM	6377	CZ	PHE	B	183	28.962	−100.269	−48.718	1.00	45.91	C
ATOM	6378	CE2	PHE	B	183	29.633	−101.216	−49.474	1.00	47.13	C
ATOM	6379	CD2	PHE	B	183	29.212	−102.534	−49.463	1.00	48.06	C
ATOM	6380	C	PHE	B	183	25.235	−103.982	−49.149	1.00	47.96	C
ATOM	6381	O	PHE	B	183	24.847	−102.938	−49.653	1.00	49.22	O
ATOM	6382	N	LEU	B	184	24.593	−104.590	−48.162	2.00	52.39	N
ATOM	6383	CA	LEU	B	184	23.383	−104.042	−47.558	1.00	49.46	C
ATOM	6384	CB	LEU	B	184	22.392	−105.151	−47.218	1.00	44.43	C
ATOM	6385	CG	LEU	B	184	21.700	−105.373	−48.367	1.00	46.28	C
ATOM	6386	CD1	LEU	B	184	21.203	−107.232	−47.899	1.00	45.44	C
ATOM	6387	CD2	LEU	B	184	20.567	−105.063	−48.989	1.00	44.51	C
ATOM	6388	C	LEU	B	184	23.760	−103.337	−46.279	1.00	50.58	C
ATOM	6389	O	LEU	B	184	24.724	−103.121	−45.624	1.00	50.61	O
ATOM	6390	N	SER	B	185	22.989	−102.316	−45.917	1.00	50.01	N
ATOM	6391	CA	SER	B	185	23.133	−101.664	−44.615	1.00	47.67	C
ATOM	6392	CB	SER	B	185	23.978	−100.415	−44.744	1.00	45.78	C
ATOM	6393	OG	SER	B	185	23.183	−99.150	−45.242	1.00	44.74	O
ATOM	6394	C	SER	B	185	21.748	−101.303	−44.080	1.00	50.24	C
ATOM	6395	O	SER	B	185	20.789	−101.155	−44.854	1.00	49.99	O
ATOM	6396	N	CYS	B	186	21.631	−101.177	−42.763	1.00	48.75	N
ATOM	6397	CA	CYS	B	186	20.363	−100.803	−42.165	1.00	47.23	C
ATOM	6398	CB	CYS	B	186	19.415	−101.998	−42.002	1.00	43.01	C
ATOM	6399	SG	CYS	B	186	19.837	−103.169	−40.696	1.00	47.04	S
ATOM	6400	C	CYS	B	186	20.565	−100.044	−40.861	1.00	49.34	C
ATOM	6401	O	CYS	B	186	21.466	−100.346	−40.077	1.00	50.86	O
ATOM	6402	N	SER	B	187	19.712	−99.045	−40.655	1.00	48.60	N
ATOM	6403	CA	SER	B	187	19.919	−98.051	−39.623	1.00	45.84	C
ATOM	6404	CB	SER	B	187	20.373	−96.136	−40.241	1.00	41.06	C
ATOM	6405	OG	SER	B	187	20.474	−95.716	−39.270	1.00	44.44	O
ATOM	6406	C	SER	B	187	18.652	−97.135	−38.829	1.00	46.18	C
ATOM	6407	O	SER	B	187	17.577	−98.301	−39.203	1.00	43.46	O
ATOM	6408	N	GLU	B	188	18.806	−97.129	−37.714	1.00	46.94	N
ATOM	6409	CA	GLU	B	188	17.680	−96.136	−36.892	1.00	47.52	C
ATOM	6410	CB	GLU	B	188	18.154	−96.448	−35.472	1.00	45.58	C
ATOM	6411	CG	GLU	B	188	18.032	−97.687	−34.604	1.00	50.71	C
ATOM	6412	CD	GLU	B	188	18.825	−97.608	−33.326	1.00	49.64	C
ATOM	6413	OE1	GLU	B	188	19.251	−96.505	−32.942	1.00	50.80	O
ATOM	6414	OE2	GLU	B	188	19.007	−98.660	−32.702	1.00	53.00	O
ATOM	6415	C	GLU	B	188	16.942	−95.546	−37.510	1.00	46.90	C
ATOM	6416	O	GLU	B	188	15.966	−95.041	−36.945	1.00	46.50	O
ATOM	6417	N	ASP	B	189	17.417	−95.215	−36.677	1.00	43.72	N
ATOM	6418	CA	ASP	B	189	16.789	−94.028	−39.392	1.00	44.30	C
ATOM	6419	CB	ASP	B	189	17.826	−93.184	−40.155	1.00	41.23	C
ATOM	6420	CG	ASP	B	189	18.343	−93.158	−41.406	1.00	40.78	C
ATOM	6421	OD1	ASP	B	189	17.976	−95.009	−41.665	1.00	40.15	O
ATOM	6422	OD2	ASP	B	189	19.132	−93.221	−42.145	1.00	44.73	O
ATOM	6423	C	ASP	B	189	15.694	−94.195	−40.289	1.00	42.28	C
ATOM	6424	O	ASP	B	189	15.146	−93.904	−41.132	1.00	40.60	O
ATOM	6425	N	ASN	B	190	15.405	−95.174	−40.079	1.00	41.95	N
ATOM	6426	CA	ASN	B	190	14.399	−96.638	−40.824	1.00	45.50	C
ATOM	6427	CB	ASN	B	190	13.009	−95.981	−40.788	1.00	43.91	C
ATOM	6428	CG	ASN	B	190	11.908	−97.011	−40.647	1.00	45.12	C
ATOM	6429	OD1	ASN	B	190	12.181	−98.200	−40.605	1.00	46.40	O
ATOM	6430	ND2	ASN	B	190	10.668	−96.565	−40.549	1.00	50.20	N
ATOM	6431	C	ASN	B	190	14.741	−97.095	−42.246	1.00	46.35	C
ATOM	6432	O	ASN	B	190	13.903	−97.117	−42.911	1.00	47.78	O
ATOM	6433	N	ARG	B	191	15.962	−96.810	−47.698	1.00	45.43	N
ATOM	6434	CA	ARG	B	191	16.380	−97.170	−44.053	1.00	45.94	C
ATOM	6435	CB	ARG	B	191	17.267	−96.086	−44.652	1.00	43.60	C
ATOM	6436	CG	ARG	B	191	16.589	−94.143	−44.898	1.00	42.05	C
ATOM	6437	CD	ARG	B	191	17.689	−93.167	−45.235	1.00	43.46	C
ATOM	6438	NE	ARG	B	191	17.225	−92.499	−45.771	1.00	43.63	N
ATOM	6439	CZ	ARG	B	191	17.211	−91.359	−45.095	1.00	42.08	C
ATOM	6440	NH1	ARG	B	191	17.622	−91.313	−43.835	1.00	38.04	N
ATOM	6441	NH2	ARG	B	191	16.783	−90.259	−45.693	1.00	50.38	N
ATOM	6442	C	ARG	B	191	17.122	−98.495	−44.124	1.00	48.00	C
ATOM	6443	O	ARG	B	191	18.018	−98.765	−43.327	1.00	53.86	O
ATOM	6444	N	ILE	B	192	16.724	−99.329	−45.073	1.00	49.37	N
ATOM	6445	CA	ILE	B	192	17.628	−100.332	−45.615	1.00	46.91	C
ATOM	6446	CB	ILE	B	192	16.957	−101.685	−45.850	1.00	46.17	C
ATOM	6447	CG1	ILE	B	192	16.268	−102.172	−44.576	1.00	42.96	C
ATOM	6448	CD1	ILE	B	192	15.325	−103.330	−44.795	1.00	46.49	C
ATOM	6449	CG2	ILE	B	192	18.017	−102.681	−46.291	1.00	48.69	C
ATOM	6450	C	ILE	B	192	18.205	−99.823	−46.935	1.00	46.90	C
ATOM	6451	O	ILE	B	192	17.469	−99.528	−47.874	1.00	49.05	O
ATOM	6452	N	LEU	B	193	19.527	−99.723	−46.995	1.00	48.29	N
ATOM	6453	CA	LEU	B	193	20.209	−99.310	−48.209	1.00	48.54	C
ATOM	6454	CB	LEU	B	193	21.191	−98.192	−47.903	1.00	45.96	C
ATOM	6455	CG	LEU	B	193	20.613	−96.909	−47.334	1.00	45.52	C
ATOM	6456	CD1	LEU	B	193	21.733	−95.956	−46.961	1.00	42.85	C
ATOM	6457	CD2	LEU	B	193	19.670	−96.273	−48.341	1.00	48.40	C
ATOM	6458	C	LEU	B	193	20.948	−100.445	−48.923	1.00	52.72	C
ATOM	6459	O	LEU	B	193	21.848	−101.087	−48.356	1.00	52.06	O
ATOM	6460	N	LEU	B	194	20.552	−100.676	−50.176	1.00	55.02	N
ATOM	6461	CA	LEU	B	194	21.345	−101.448	−51.124	1.00	51.05	C
ATOM	6462	CB	LEU	B	194	20.458	−101.972	−52.256	1.00	52.26	C
ATOM	6463	CG	LEU	B	194	21.049	−102.947	−53.293	1.00	49.95	C
ATOM	6464	CD1	LEU	B	194	21.608	−104.180	−52.601	1.00	44.60	C
ATOM	6465	CD2	LEU	B	194	19.996	−103.344	−54.323	1.00	48.50	C
ATOM	6466	C	LEU	B	194	22.471	−100.597	−51.698	1.00	47.06	C
ATOM	6467	O	LEU	B	194	22.225	−99.581	−52.349	1.00	46.72	O
ATOM	6468	N	TRP	B	195	23.708	−101.005	−51.461	1.00	46.76	N
ATOM	6469	CA	TRP	B	195	24.864	−100.256	−51.940	1.00	45.60	C
ATOM	6470	CB	TRP	B	195	25.923	−100.198	−50.869	1.00	48.32	C
ATOM	6471	CG	TRP	B	195	25.516	−99.421	−49.681	1.00	51.22	C
ATOM	6472	CD1	TRP	B	195	24.689	−99.831	−48.668	1.00	49.99	C
ATOM	6473	NE1	TRP	B	195	24.564	−98.839	−47.733	1.00	49.37	N
ATOM	6474	CE2	TRP	B	195	25.325	−97.767	−48.115	1.00	48.23	C
ATOM	6475	CD2	TRP	B	195	25.939	−98.101	−49.346	1.00	49.54	C
ATOM	6476	CE3	TRP	B	195	26.783	−97.164	−49.964	1.00	50.45	C
ATOM	6477	CZ3	TRP	B	195	26.973	−95.928	−49.343	1.00	52.27	C
ATOM	6478	CH2	TRP	B	195	26.331	−95.624	−48.119	1.00	50.79	C
ATOM	6479	CZ2	TRP	B	195	25.513	−96.535	−47.492	1.00	48.64	C
ATOM	6480	C	TRP	B	195	25.474	−100.677	−55.160	1.00	46.67	C
ATOM	6481	O	TRP	B	195	25.385	−102.082	−53.378	1.00	49.56	O
ATOM	6482	N	ASP	B	196	26.051	−100.027	−54.022	1.00	46.95	N
ATOM	6483	CA	ASP	B	196	26.861	−100.427	−55.153	1.00	45.30	C
ATOM	6484	CB	ASP	B	196	26.036	−100.677	−56.421	1.00	45.57	C
ATOM	6485	CG	ASP	B	196	26.857	−101.404	−57.527	1.00	48.42	C
ATOM	6486	OD1	ASP	B	196	28.128	−101.365	−57.515	1.00	48.16	O
ATOM	6487	OD2	ASP	B	196	26.225	−102.025	−58.407	1.00	42.72	O
ATOM	6488	C	ASP	B	196	27.826	−99.306	−55.421	1.00	43.95	C
ATOM	6489	O	ASP	B	196	27.464	−98.326	−56.074	1.00	40.58	O
ATOM	6490	N	THR	B	197	29.056	−99.456	−54.940	1.00	43.27	N
ATOM	6491	CA	THR	B	197	30.043	−98.386	−55.048	1.00	45.83	C
ATOM	6492	CB	THR	B	197	31.271	−98.628	−54.145	1.00	47.18	C
ATOM	6493	OG1	THR	B	197	31.855	−99.902	−54.436	1.00	47.32	O
ATOM	6494	CG2	THR	B	197	30.866	−98.569	−52.681	1.00	50.63	C
ATOM	6495	C	THR	B	197	30.504	−98.061	−56.475	1.00	46.51	C
ATOM	6496	O	THR	B	197	31.317	−97.149	−56.677	1.00	47.70	O
ATOM	6497	N	ARG	B	198	29.989	−98.790	−57.459	1.00	45.50	N
ATOM	6498	CA	ARG	B	198	30.303	−98.487	−58.856	1.00	51.52	C
ATOM	6499	CB	ARG	B	198	30.040	−99.705	−59.754	1.00	52.25	C
ATOM	6500	CG	ARG	B	198	31.047	−100.852	−59.565	1.00	45.62	C
ATOM	6501	CD	ARG	B	198	30.623	−102.140	−60.277	1.00	44.90	C
ATOM	6502	NE	ARG	B	198	29.288	−102.600	−59.897	1.00	45.05	N
ATOM	6503	CZ	ARG	B	198	28.791	−103.816	−60.126	1.00	47.24	C
ATOM	6504	NB1	ARG	B	198	29.506	−104.744	−60.747	1.00	52.04	N
ATOM	6505	NB2	ARG	B	198	27.565	−104.115	−59.723	1.00	41.66	5
ATOM	6506	C	ARG	B	198	29.540	−97.242	−59.336	1.00	52.90	C
ATOM	6507	O	ARG	B	198	30.025	−96.500	−60.198	1.00	54.00	O
ATOM	6508	N	CYS	B	199	28.364	−97.024	−58.738	1.00	50.58	N
ATOM	6509	CA	CYS	B	199	27.496	−95.867	−58.976	1.00	49.57	C
ATOM	6510	CB	CYS	B	199	26.117	−96.167	−58.426	1.00	45.40	C
ATOM	6511	SG	CYS	B	199	25.407	−97.643	−59.169	1.00	47.17	S
ATOM	6512	O	CYS	B	199	27.980	−94.547	−58.367	1.00	52.36	C
ATOM	6513	O	CYS	B	199	28.766	−94.529	−57.251	1.00	50.67	O
ATOM	6514	N	PRO	B	200	27.766	−93.427	−59.089	1.00	54.08	N
ATOM	6515	CA	PRO	B	200	28.125	−92.109	−58.561	1.00	58.63	C
ATOM	6516	CB	PRO	B	200	27.608	−91.149	−59.640	1.00	59.65	C
ATOM	6517	CG	PRO	B	200	27.678	−91.952	−60.896	1.00	57.61	C
ATOM	6518	CD	PRO	B	200	27.223	−93.324	−60.455	1.00	56.34	C
ATOM	6519	C	PRO	B	200	27.432	−91.150	−57.223	1.00	59.01	C
ATOM	6520	O	PRO	B	200	28.075	−91.182	−56.286	1.00	58.67	O
ATOM	6521	N	LYS	B	201	26.138	−92.173	−57.148	1.00	56.98	N
ATOM	6522	CA	LYS	B	201	25.402	−92.192	−55.893	1.00	51.10	C
ATOM	6523	CB	LYS	B	201	24.077	−91.430	−56.024	1.00	55.44	C
ATOM	6524	CG	LYS	B	201	24.220	−89.914	−56.002	1.00	58.80	C
ATOM	6525	CD	LYS	B	201	22.860	−89.147	−56.191	1.00	61.49	C
ATOM	6526	CE	LYS	B	201	22.898	−87.159	−55.859	1.00	62.02	C
ATOM	6527	NZ	LYS	B	201	21.531	−87.198	−55.609	1.00	63.13	N
ATOM	6528	C	LYS	B	201	25.158	−93.650	−55.488	1.00	49.48	C
ATOM	6529	O	LYS	B	201	24.182	−94.263	−55.944	1.00	48.49	O
ATOM	6530	N	PRO	B	202	26.045	−94.199	−54.621	1.00	47.46	N
ATOM	6531	CA	PRO	B	202	26.190	−95.614	−54.241	1.00	45.00	C
ATOM	6532	CB	PRO	B	202	27.373	−95.601	−53.279	1.00	46.03	C
ATOM	6533	CG	PRO	B	202	27.649	−94.175	−52.948	1.00	42.61	C
ATOM	6534	CD	PRO	B	202	27.177	−93.397	−54.123	1.00	44.35	C
ATOM	6535	C	PRO	B	202	25.018	−96.298	−53.557	1.00	49.69	C
ATOM	6536	O	PRO	B	202	24.756	−97.483	−53.813	1.00	54.45	O
ATOM	6537	N	ALA	B	203	24.330	−95.589	−52.673	1.00	49.65	N
ATOM	6538	CA	ALA	B	203	23.228	−96.204	−51.929	1.00	49.10	C
ATOM	6539	CB	ALA	B	203	23.117	−95.587	−50.545	1.00	49.64	C
ATOM	6540	C	ALA	B	203	21.912	−96.061	−52.666	1.00	48.26	C
ATOM	6541	O	ALA	B	203	21.723	−95.146	−53.465	1.00	52.14	O
ATOM	6542	N	SER	B	204	21.000	−96.972	−52.393	1.00	47.53	N
ATOM	6543	CA	SER	B	204	19.659	−96.885	−52.922	1.00	52.70	C
ATOM	6544	CB	SER	B	204	19.546	−97.635	−54.243	1.00	54.21	C
ATOM	6545	OG	SER	B	204	18.191	−97.950	−54.522	1.00	58.59	O
ATOM	6546	C	SER	B	204	18.731	−97.484	−51.876	1.00	56.19	C
ATOM	6547	O	SER	B	204	18.994	−98.578	−51.363	1.00	51.72	O
ATOM	6548	N	GLN	B	205	17.662	−96.154	−51.557	1.00	56.91	N
ATOM	6549	CA	GLN	B	205	16.752	−97.140	−50.479	1.00	59.16	C
ATOM	6550	CB	GLN	B	205	15.994	−95.916	−49.938	1.00	59.60	C
ATOM	6551	CG	GLN	B	205	14.966	−96.256	−48.868	1.00	64.73	C
ATOM	6552	CD	GLN	B	205	14.597	−95.082	−47.978	1.00	66.53	C
ATOM	6553	OE1	GLN	B	205	15.097	−93.959	−48.139	1.00	61.28	O
ATOM	6554	NE2	GLN	B	205	13.720	−95.347	−47.014	1.00	68.46	N
ATOM	6555	C	GLN	B	205	15.787	−98.227	−50.920	1.00	57.60	C
ATOM	6556	O	GLN	B	205	15.091	−98.077	−51.922	1.00	58.47	O
ATOM	6557	N	ILE	B	206	15.752	−99.322	−50.171	1.00	58.48	N
ATOM	6558	CA	ILE	B	206	14.923	−100.466	−50.545	1.00	63.78	C
ATOM	6559	CB	ILE	B	206	15.765	−101.593	−51.226	1.00	67.07	C
ATOM	6560	CG1	ILE	B	206	14.872	−102.773	−51.641	1.00	73.77	C
ATOM	6561	CD1	ILE	B	206	15.280	−103.473	−52.926	1.00	81.52	C
ATOM	6562	CG2	ILE	B	206	16.932	−102.048	−50.347	1.00	59.50	C
ATOM	6563	C	ILE	B	206	14.094	−100.982	−49.367	1.00	65.05	C
ATOM	6564	O	ILE	B	206	14.389	−100.677	−48.216	1.00	71.43	O
ATOM	6565	N	GLY	B	207	13.058	−101.755	−49.668	1.00	69.02	N
ATOM	6566	CA	GLY	B	207	12.215	−102.363	−48.648	1.00	76.76	C
ATOM	6567	C	GLY	B	207	10.752	−102.374	−49.050	1.00	83.48	C
ATOM	6568	O	GLY	B	207	10.408	−102.035	−50.186	1.00	84.83	O
ATOM	6569	N	CYS	B	208	9.890	−102.747	−48.107	1.00	87.58	N
ATOM	6570	CA	CYS	B	208	8.464	−102.931	−48.384	1.00	97.06	C
ATOM	6571	CB	CYS	B	208	7.750	−103.532	−47.168	1.00	96.17	C
ATOM	6572	SG	CYS	B	208	8.613	−104.508	−46.361	1.00	97.87	S
ATOM	6573	C	CYS	B	208	7.779	−101.637	−48.826	1.00	100.95	C
ATOM	6574	O	CYS	B	208	8.355	−100.547	−48.709	1.00	97.23	O
ATOM	6575	N	SER	B	209	6.559	−101.775	−49.350	1.00	103.64	N
ATOM	6576	CA	SER	B	209	5.740	−100.627	−49.742	1.00	101.10	C
ATOM	6577	CB	SER	B	209	4.325	−101.072	−50.132	1.00	97.87	C
ATOM	6578	OG	SER	B	209	4.353	−102.009	−51.190	1.00	50.13	O
ATOM	6579	C	SER	B	209	5.682	−99.610	−48.600	1.00	98.95	C
ATOM	6580	O	SER	B	209	6.337	−98.566	−48.661	1.00	90.82	O
ATOM	6581	N	ALA	B	210	4.917	−99.939	−47.557	1.00	97.90	N
ATOM	6582	CA	ALA	B	210	4.796	−99.087	−46.374	1.00	94.18	C
ATOM	6583	CB	ALA	B	210	3.538	−99.437	−45.585	1.00	88.51	C
ATOM	6584	C	ALA	B	210	6.033	−99.204	−45.484	1.00	89.21	C
ATOM	6585	O	ALA	B	210	6.482	−100.328	−45.197	1.00	80.08	O
ATOM	6586	N	PRO	B	211	6.606	−98.046	−45.073	1.00	85.86	N
ATOM	6587	CA	PRO	B	211	7.574	−98.033	−43.972	1.00	81.23	C
ATOM	6588	CB	PRO	B	211	7.792	−96.539	−43.717	1.00	78.50	C
ATOM	6589	CG	PRO	B	211	7.619	−95.928	−45.066	1.00	80.90	C
ATOM	6590	CD	PRO	B	211	6.526	−96.727	−45.735	1.00	82.92	C
ATOM	6591	C	PRO	B	211	6.989	−98.729	−42.738	1.00	72.06	C
ATOM	6592	O	PRO	B	211	5.810	−98.540	−42.404	1.00	67.44	O
ATOM	6593	N	GLY	B	212	7.807	−99.562	−42.106	1.00	61.06	N
ATOM	6594	CA	GLY	B	212	7.378	−100.350	−40.970	1.00	58.55	C
ATOM	6595	C	GLY	B	212	8.255	−100.148	−39.747	1.00	56.60	C
ATOM	6596	O	GLY	B	212	8.695	−99.029	−39.436	1.00	55.60	O
ATOM	6597	N	TYR	B	213	8.509	−101.247	−39.051	1.00	51.17	N
ATOM	6598	CA	TYR	B	213	9.328	−101.218	−37.860	1.00	48.44	C
ATOM	6599	CB	TYR	B	213	8.962	−102.409	−36.999	1.00	48.19	C
ATOM	6600	CG	TYR	B	213	7.582	−102.276	−36.392	1.00	50.77	C
ATOM	6601	CD1	TYR	B	213	7.314	−101.287	−35.432	1.00	52.96	C
ATOM	6602	CE1	TYR	B	213	6.061	−101.152	−34.856	1.00	50.08	C
ATOM	6603	CZ	TYR	B	213	5.047	−102.013	−35.239	1.00	53.49	C
ATOM	6604	OH	TYR	B	213	3.809	−101.876	−34.666	1.00	43.47	O
ATOM	6605	CE2	TYR	B	213	5.278	−103.006	−36.191	1.00	53.93	C
ATOM	6606	CD2	TYR	B	213	0.542	−105.150	−36.765	1.00	52.74	C
ATOM	6607	C	TYR	B	213	10.805	−101.203	−38.242	1.00	47.05	C
ATOM	6608	O	TYR	B	213	11.170	−101.694	−39.309	1.00	47.43	O
ATOM	6609	N	LEU	B	214	11.645	−100.611	−37.392	1.00	48.80	N
ATOM	6610	CA	LEU	B	214	13.066	−100.400	−37.721	1.00	44.85	C
ATOM	6611	CB	LEU	B	214	13.820	−99.742	−36.566	1.00	43.48	C
ATOM	6612	CG	LEU	B	214	13.448	−98.318	−36.156	1.00	47.66	C
ATOM	6613	CD1	LEU	B	214	14.347	−97.815	−35.025	1.00	43.61	C
ATOM	6614	CD2	LEU	B	214	13.501	−97.372	−37.351	1.00	45.37	C
ATOM	6615	C	LEU	B	214	13.751	−101.711	−38.080	1.00	45.96	C
ATOM	6616	O	LEU	B	214	13.457	−102.744	−37.471	1.00	47.77	O
ATOM	6617	N	PRO	B	215	14.673	−101.673	−39.062	1.00	43.74	N
ATOM	6618	CA	PRO	B	215	15.379	−102.881	−39.460	1.00	40.33	C
ATOM	6619	CB	PRO	B	215	15.869	−102.542	−40.878	1.00	30.81	C
ATOM	6620	CG	PRO	B	215	15.931	−101.047	−40.943	1.00	35.55	C
ATOM	6621	CD	PRO	B	215	15.163	−100.482	−39.787	1.00	41.25	C
ATOM	6622	C	PRO	B	215	16.530	−103.152	−38.519	1.00	33.29	C
ATOM	6623	O	PRO	B	215	17.248	−102.221	−38.169	1.00	41.02	O
ATOM	6624	N	THR	B	216	16.714	−104.409	−38.122	1.00	33.06	N
ATOM	6625	CA	THR	B	216	17.705	−104.754	−37.087	1.00	45.97	C
ATOM	6626	CB	THR	B	216	17.030	−105.169	−35.758	1.00	41.44	C
ATOM	6627	OG1	THR	B	216	16.092	−106.248	−35.984	1.00	40.41	O
ATOM	6628	CG2	THR	B	216	16.323	−103.971	−35.124	1.00	44.92	C
ATOM	6629	C	THR	B	216	18.690	−105.864	−37.455	1.00	47.42	C
ATOM	6630	O	THR	B	216	19.640	−106.099	−36.718	1.00	51.78	O
ATOM	6631	N	SER	B	217	18.462	−106.566	−38.565	1.00	48.48	N
ATOM	6632	CA	SER	B	217	19.376	−107.632	−38.990	1.00	49.17	C
ATOM	6633	CB	SER	B	217	19.180	−108.887	−38.143	1.00	50.29	C
ATOM	6634	OG	SER	B	217	17.808	−109.268	−38.108	1.00	52.33	O
ATOM	6635	C	SER	B	217	19.197	−107.969	−40.468	1.00	51.83	C
ATOM	6636	O	SER	B	217	18.069	−107.916	−40.994	1.00	43.46	O
ATOM	6637	N	LEU	B	218	20.311	−108.313	−41.127	1.00	47.73	N
ATOM	6638	CA	LEU	B	218	20.305	−108.648	−42.553	1.00	46.63	C
ATOM	6639	CB	LEU	B	218	20.844	−107.485	−43.390	1.00	41.60	C
ATOM	6640	CG	LEU	B	218	20.485	−106.032	−43.130	1.00	41.90	C
ATOM	6641	CD1	LEU	B	218	21.682	−105.131	−43.439	1.00	41.08	C
ATOM	6642	CD2	LEU	B	218	19.246	−105.624	−43.928	1.00	43.61	C
ATOM	6643	C	LEU	B	218	21.148	−109.871	−42.892	100	50.36	C
ATOM	6644	O	LEU	B	218	22.262	−110.039	−42.373	100	53.19	O
ATOM	6645	N	ALA	B	219	20.639	−110.694	−43.804	1.00	50.75	N
ATOM	6646	CA	ALA	B	219	21.427	−111.181	−44.382	1.00	51.21	C
ATOM	6647	CB	ALA	B	219	21.214	−113.066	−43.602	1.00	52.00	C
ATOM	6648	C	ALA	B	219	21.074	−111.993	−45.850	1.00	53.82	C
ATOM	6649	O	ALA	B	219	19.902	−112.179	−46.198	1.00	52.45	O
ATOM	6650	N	TRP	B	220	22.091	−111.968	−46.711	1.00	55.86	N
ATOM	6651	CA	TRP	B	220	21.908	−112.318	−48.119	1.00	54.14	C
ATOM	6652	CB	TRP	B	220	23.176	−112.018	−48.907	1.00	51.59	C
ATOM	6653	CG	TRP	B	220	23.490	−110.568	−49.136	1.00	49.01	C
ATOM	6654	CD1	TRP	B	220	24.320	−109.776	−48.385	1.00	51.13	C
ATOM	6655	NE1	TRP	B	220	24.392	−108.506	−48.929	1.00	48.54	N
ATOM	6656	CE2	TRP	B	220	23.613	−108.468	−50.057	1.00	46.59	C
ATOM	6657	CD2	TRP	B	220	23.037	−109.152	−50.224	1.00	47.66	C
ATOM	6658	CE3	TRP	B	220	22.187	−109.975	−51.317	1.00	52.10	C
ATOM	6659	CZ3	TRP	B	220	21.941	−108.915	−52.203	1.00	48.19	C
ATOM	6660	CH2	TRP	B	220	22.536	−107.656	−52.005	1.00	47.61	C
ATOM	6661	CZ2	TRP	B	220	23.366	−107.415	−50.941	1.00	45.73	C
ATOM	6662	C	TRP	B	220	21.627	−113.807	−48.215	1.00	52.77	C
ATOM	6663	O	TRP	B	220	22.076	−114.564	−47.362	1.00	53.16	O
ATOM	6664	N	HIS	B	221	20.883	−114.223	−49.238	1.00	58.39	N
ATOM	6665	CA	HIS	B	221	20.708	−115.654	−49.546	1.00	63.78	C
ATOM	6666	CB	HIS	B	221	19.549	−115.864	−50.511	1.00	68.61	C
ATOM	6667	CG	HIS	B	221	19.009	−117.260	−50.528	1.00	75.84	C
ATOM	6668	ND1	HIS	B	221	19.528	−118.250	−51.335	1.00	83.58	N
ATOM	6669	CE1	HIS	B	221	18.844	−119.367	−51.154	1.00	83.69	C
ATOM	6670	NE2	HIS	B	221	17.891	−119.133	−50.269	1.00	76.83	N
ATOM	6671	CD2	HIS	B	221	17.971	−117.823	−49.864	1.00	75.45	C
ATOM	6672	C	HIS	B	221	21.988	−116.132	−50.200	1.00	62.91	C
ATOM	6673	O	HIS	B	221	22.505	−115.460	−51.093	1.00	62.25	O
ATOM	6674	N	PRO	B	222	22.513	−117.289	−49.765	1.00	63.45	N
ATOM	6675	CA	PRO	B	222	23.843	−117.624	−50.260	1.00	63.40	C
ATOM	6676	CB	PRO	B	222	24.312	−118.738	−49.319	1.00	60.35	C
ATOM	6677	CG	PRO	B	222	23.121	−119.144	−48.506	1.00	61.84	C
ATOM	6678	CD	PRO	B	222	21.922	−118.177	−48.969	1.00	61.06	C
ATOM	6679	C	PRO	B	222	23.881	−118.061	−51.741	1.00	67.15	C
ATOM	6680	O	PRO	B	222	24.963	−118.118	−52.320	1.00	63.24	O
ATOM	6681	N	GLN	B	223	22.721	−118.119	−52.355	1.00	67.84	N
ATOM	6682	CA	GLN	B	223	22.675	−118.699	−53.775	1.00	73.25	C
ATOM	6683	CB	GLN	B	223	22.074	−120.083	−53.928	1.00	74.05	C
ATOM	6684	CG	GLN	B	223	23.051	−121.165	−53.524	1.00	77.35	C
ATOM	6685	CD	GLN	B	223	22.429	−122.142	−52.568	1.00	76.75	C
ATOM	6686	OE1	GLN	B	223	21.204	−122.209	−52.450	1.00	76.09	O
ATOM	6687	NE2	GLN	B	223	23.266	−122.906	−51.874	1.00	78.80	N
ATOM	6688	C	GLN	B	223	21.949	−117.706	−54.674	1.00	79.55	C
ATOM	6689	C	GLN	B	223	22.554	−117.322	−55.588	1.00	80.08	O
ATOM	6699	N	GLN	B	224	20.652	−117.539	−54.425	1.00	81.13	N
ATOM	6691	CA	GLN	B	224	19.863	−116.518	−55.093	1.00	80.09	C
ATOM	6692	CB	GLN	B	234	18.390	−116.670	−54.725	1.00	82.77	C
ATOM	6693	CG	GLN	B	224	17.827	−118.053	−55.024	1.00	88.07	C
ATOM	6694	CD	GLN	B	224	16.685	−118.455	−54.103	1.00	97.01	C
ATOM	6695	OE1	GLN	B	224	16.794	−118.379	−52.878	1.00	98.43	O
ATOM	6695	NE2	GLN	B	224	15.585	−118.910	−54.694	1.00	100.61	N
ATOM	6697	C	GLN	B	224	20.429	−115.170	−54.662	1.00	84.28	C
ATOM	6698	O	GLN	B	224	19.945	−114.544	−53.719	1.00	88.72	O
ATOM	6699	N	SER	B	225	21.478	−114.749	−55.364	1.00	89.17	N
ATOM	6700	CA	SER	B	225	22.331	−113.617	−54.979	1.00	96.78	C
ATOM	6701	CB	SER	B	225	23.611	−113.627	−55.845	1.00	101.96	C
ATOM	6702	OG	SER	B	225	24.790	−113.359	−55.090	1.00	96.73	O
ATOM	6703	C	SER	B	225	21.609	−112.262	−55.074	1.00	92.00	C
ATOM	6704	O	SER	B	225	22.221	−111.195	−54.917	1.00	90.50	O
ATOM	6705	N	GLU	B	226	20.303	−112.324	−55.325	1.00	91.48	N
ATOM	6706	CA	GLU	B	226	19.461	−111.135	−55.470	1.00	91.04	C
ATOM	6707	CB	GLU	B	226	18.772	−111.101	−56.847	1.00	97.84	C
ATOM	6708	CG	GLU	B	226	19.515	−111.791	−57.988	1.00	107.67	C
ATOM	6709	CD	GLU	B	226	19.234	−113.292	−58.078	1.00	117.02	C
ATOM	6710	OE1	GLU	B	226	18.763	−113.901	−57.083	1.00	109.05	O
ATOM	6711	OE2	GLU	B	226	19.496	−113.871	−59.158	1.00	123.34	O
ATOM	6712	C	GLU	B	226	18.399	−111.084	−54.367	1.00	82.76	C
ATOM	6713	O	GLU	B	226	17.570	−110.161	−54.333	1.00	83.85	O
ATOM	6714	N	VAL	B	227	18.410	−112.083	−53.482	1.00	70.57	N
ATOM	6715	CA	VAL	B	227	17.475	−112.106	−52.355	1.00	67.27	C
ATOM	6716	CB	VAL	B	227	16.483	−113.317	−52.366	1.00	66.65	C
ATOM	6717	CG1	VAL	B	227	16.128	−113.764	−53.783	1.00	66.31	C
ATOM	6718	CG2	VAL	B	227	17.012	−114.487	−51.363	1.00	65.69	C
ATOM	6719	C	VAL	B	227	18.177	−111.985	−51.001	1.00	64.13	C
ATOM	6720	O	VAL	B	227	19.274	−112.508	−50.790	1.00	62.39	O
ATOM	6721	N	PHE	B	228	17.542	−111.259	−50.092	1.00	63.21	N
ATOM	6722	CA	PHE	B	228	17.995	−111.229	−48.713	1.00	59.74	C
ATOM	6723	CB	PHE	B	228	18.866	−110.004	−48.437	1.00	57.20	C
ATOM	6724	CG	PHE	B	228	18.151	−108.682	−48.569	1.00	59.99	C
ATOM	6725	CD1	PHE	B	228	18.027	−108.057	−49.804	1.00	62.80	C
ATOM	6726	CE1	PHE	B	228	17.387	−106.827	−49.916	1.00	60.93	C
ATOM	6727	CZ	PHE	B	228	16.884	−106.203	−48.789	1.00	59.44	C
ATOM	6728	CE2	PHE	B	228	17.011	−106.805	−47.553	1.00	56.54	C
ATOM	6729	CD2	PHE	B	228	17.650	−108.029	−47.445	1.00	60.45	C
ATOM	6730	C	PHE	B	228	16.814	−111.285	−47.769	1.00	55.67	C
ATOM	6731	O	PHE	B	228	15.694	−110.978	−48.161	1.00	55.04	O
ATOM	6732	N	VAL	B	229	17.070	−111.720	−48.541	1.00	51.35	N
ATOM	6733	CA	VAL	B	229	16.113	−111.556	−45.453	1.00	58.31	C
ATOM	6734	CB	VAL	B	229	16.001	−112.821	−44.570	1.00	59.88	C
ATOM	6735	CG1	VAL	B	229	15.326	−113.950	−45.336	1.00	60.26	C
ATOM	6736	CC2	VAL	B	229	17.368	−113.242	−44.031	1.00	55.68	C
ATOM	6737	C	VAL	B	229	16.500	−110.360	−44.578	1.00	57.06	C
ATOM	6738	O	VAL	B	229	17.678	−110.005	−44.483	1.00	53.72	O
ATOM	6739	N	PHE	B	230	15.508	−109.726	−43.958	1.00	57.98	N
ATOM	6740	CA	PHE	B	230	15.797	−108.768	−42.891	1.00	58.30	C
ATOM	6741	CB	PHE	B	230	15.851	−107.322	−43.403	1.00	61.76	C
ATOM	6742	CG	PHE	B	230	14.510	−106.660	−43.535	1.00	63.31	C
ATOM	6743	CD1	PHE	B	230	13.757	−106.807	−44.695	1.00	63.87	C
ATOM	6744	CE1	PHE	B	230	12.528	−106.184	−44.828	1.00	65.25	C
ATOM	6745	CZ	PHE	B	230	12.038	−105.394	−43.793	1.00	63.13	C
ATOM	6748	CZ2	PHE	B	230	12.785	−105.233	−42.636	1.00	63.55	C
ATOM	6747	CD2	PHE	B	230	14.011	−105.859	−42.514	1.00	61.43	C
ATOM	6748	C	PHE	B	230	14.872	−108.912	−41.696	1.00	51.62	C
ATOM	6749	O	PHE	B	230	13.699	−109.266	−41.834	1.00	62.33	O
ATOM	6750	N	GLY	B	231	15.419	−108.667	−40.517	1.00	43.63	N
ATOM	6751	CA	GLY	B	231	14.654	−108.795	−39.295	1.00	45.82	C
ATOM	6752	C	GLY	B	231	14.389	−107.421	−38.742	1.00	43.84	C
ATOM	6753	O	GLY	B	231	15.204	−106.523	−38.893	1.00	43.45	O
ATOM	6754	N	ASP	B	232	13.251	−107.236	−38.096	1.00	43.91	N
ATOM	6755	A	ASP	B	232	12.964	−105.928	−37.533	1.00	43.90	C
ATOM	6756	CA	ASP	B	232	11.697	−105.310	−38.179	1.00	43.53	C
ATOM	6757	CB	ASP	B	232	10.410	−106.038	−37.802	1.00	51.84	C
ATOM	6758	OD1	ASP	B	23	10.440	−106.913	−36.903	1.00	54.37	O
ATOM	6759	OD2	ASP	B	232	9.350	−105.721	−38.406	1.00	54.57	O
ATOM	6760	C	ASP	B	232	12.913	−105.937	−36.003	1.00	43.32	C
ATOM	6761	O	ASP	B	232	12.972	−106.994	−35.366	1.00	42.62	O
ATOM	6762	N	GLU	B	233	12.782	−104.109	−35.426	1.00	46.16	N
ATOM	6763	CA	GLU	B	233	12.708	−104.185	−33.971	1.00	49.17	C
ATOM	6764	CB	GLU	B	233	12.836	−103.115	−33.614	1.00	50.41	C
ATOM	6765	CG	GLU	B	233	11.615	−102.110	−34.031	1.00	50.69	C
ATOM	6766	CD	GLU	B	233	11.801	−100.827	−33.821	1.00	54.72	C
ATOM	6767	OE1	GLU	B	233	12.702	−100.445	−33.021	1.00	54.40	O
ATOM	6768	OE2	GLU	B	233	11.047	−100.055	−34.469	1.00	53.53	O
ATOM	6769	C	GLU	B	233	11.418	−105.329	−33.354	1.00	50.69	C
ATOM	6770	O	GLU	B	233	11.262	−105.095	−32.136	1.00	53.21	O
ATOM	6771	N	ASN	B	234	10.505	−105.025	−34.183	1.00	47.41	N
ATOM	6772	CA	ASN	B	234	9.247	−106.255	−33.679	1.00	48.42	C
ATOM	6773	CB	ASN	B	234	8.052	−105.102	−34.389	1.00	49.25	C
ATOM	6774	CG	ASN	B	234	6.777	−105.195	−33.574	1.00	53.44	C
ATOM	6775	OD1	ASN	B	234	6.796	−105.433	−32.345	1.00	51.90	O
ATOM	6776	ND2	ASN	B	234	5.664	−105.172	−34.245	1.00	50.61	N
ATOM	6777	C	ASN	B	234	9.140	−107.869	−33.769	1.00	48.05	C
ATOM	6778	O	ASN	B	234	8.116	−108.235	−33.413	1.00	44.76	O
ATOM	6779	N	GLY	B	235	10.196	−108.124	−34.254	1.00	49.94	N
ATOM	6780	CA	GLY	B	235	10.278	−109.387	−34.202	1.00	47.14	C
ATOM	6781	C	GLY	B	235	9.903	−110.467	−35.499	1.00	46.68	C
ATOM	6782	O	GLY	B	235	9.784	−111.497	−35.567	1.00	44.02	O
ATOM	6783	N	THR	B	236	9.743	−109.447	−36.528	1.00	45.46	N
ATOM	6784	CA	THR	B	236	9.355	−110.301	−37.835	1.00	48.24	C
ATOM	6785	CB	THR	B	236	8.334	−109.330	−38.452	1.00	49.18	C
ATOM	6786	OG1	THR	B	236	7.145	−109.366	−37.660	1.00	48.92	O
ATOM	6787	CG2	THR	B	236	8.012	−109.503	−39.912	1.00	46.60	C
ATOM	6788	C	THR	B	236	10.559	−110.341	−38.783	1.00	49.02	C
ATOM	6789	O	THR	B	236	11.351	−109.320	−38.923	1.00	50.66	O
ATOM	6790	N	VAL	B	237	10.672	−111.427	−39.330	1.00	53.51	N
ATOM	6791	CA	VAL	B	237	11.653	−111.330	−40.354	1.00	53.01	C
ATOM	6792	CB	VAL	B	237	12.227	−113.244	−40.145	1.00	50.20	C
ATOM	6793	CG1	VAL	B	237	13.006	−113.610	−41.376	1.00	30.16	C
ATOM	6794	CG2	VAL	B	237	13.089	−113.364	−38.887	1.00	47.26	C
ATOM	6795	C	VAL	B	237	10.940	−111.645	−41.697	1.00	54.01	C
ATOM	6796	O	VAL	B	237	9.818	−112.366	−41.855	1.00	53.00	O
ATOM	6797	N	SER	B	238	11.586	−110.971	−42.645	1.00	51.79	N
ATOM	6798	CA	SER	B	238	11.000	−110.327	−43.949	1.00	54.11	C
ATOM	6799	CB	SER	B	238	10.470	−109.301	−44.031	1.00	53.21	C
ATOM	6800	OG	SER	B	238	9.403	−109.331	−43.119	1.00	55.74	O
ATOM	6801	C	SER	B	238	12.000	−110.585	−45.061	1.00	60.16	C
ATOM	6802	O	SER	B	238	13.206	−110.364	−44.902	1.00	67.46	O
ATOM	6803	N	LEU	B	239	11.477	−111.443	−46.193	1.00	62.87	N
ATOM	6804	CA	LEU	B	239	12.280	−111.828	−47.344	1.00	62.68	C
ATOM	6805	CB	LEU	B	239	11.945	−113.376	−47.737	1.00	63.72	C
ATOM	6806	CG	LEU	B	239	12.078	−113.889	−49.130	1.00	67.13	C
ATOM	6807	CD1	LEU	B	239	13.528	−114.125	−49.525	1.00	68.98	C
ATOM	6808	CD2	LEU	B	239	11.321	−115.303	−49.124	1.00	65.40	C
ATOM	6809	C	LEU	B	239	12.067	−110.829	−48.478	1.00	59.66	C
ATOM	6810	O	LEU	B	239	10.941	−110.584	−48.910	1.00	59.67	O
ATOM	6811	N	VAL	B	240	13.167	−110.227	−48.915	1.00	59.98	N
ATOM	6812	CA	VAL	B	240	13.160	−109.233	−49.972	1.00	61.21	C
ATOM	6813	CB	VAL	B	240	13.824	−107.330	−49.512	1.00	59.21	C
ATOM	6814	CG1	VAL	B	240	13.591	−106.818	−50.534	1.00	56.34	C
ATOM	6815	CG2	VAL	B	240	13.310	−107.523	−48.154	1.00	56.32	C
ATOM	6816	C	VAL	B	240	13.902	−109.700	−51.229	1.00	69.67	C
ATOM	6817	O	VAL	B	240	14.924	−110.405	−51.154	1.00	65.53	O
ATOM	6818	N	ASP	B	241	13.362	−109.280	−52.373	1.00	76.53	N
ATOM	6819	CA	ASP	B	241	13.964	−109.453	−53.689	1.00	81.39	C
ATOM	6820	CB	ASP	B	241	12.907	−110.018	−54.649	1.00	83.32	C
ATOM	6821	CG	ASP	B	241	13.506	−110.656	−55.901	1.00	87.46	C
ATOM	6822	OD1	ASP	B	241	14.253	−109.976	−56.636	1.00	96.81	O
ATOM	6823	OD2	ASP	B	241	13.200	−111.838	−56.171	1.00	78.82	O
ATOM	6824	C	ASP	B	241	14.426	−108.672	−54.158	1.00	80.31	C
ATOM	6825	O	ASP	B	241	13.662	−107.106	−54.093	1.00	89.48	O
ATOM	6826	N	THR	B	242	15.667	−107.964	−54.617	1.00	78.54	N
ATOM	6827	CA	THR	B	242	16.153	−106.683	−55.143	1.00	80.15	C
ATOM	6828	CB	THR	B	242	17.692	−106.600	−55.167	1.00	78.00	C
ATOM	6829	OG1	THR	B	242	18.230	−107.664	−55.966	1.00	86.54	O
ATOM	6830	CG2	THR	B	242	18.234	−106.715	−53.773	1.00	75.73	C
ATOM	6831	C	THR	B	242	15.571	−106.338	−56.524	1.00	81.95	C
ATOM	6832	O	THR	B	242	15.244	−105.178	−56.782	1.00	79.10	O
ATOM	6833	N	LYS	B	243	15.432	−107.350	−57.387	1.00	89.88	N
ATOM	6834	CA	LYS	B	243	14.877	−107.189	−58.745	1.00	100.06	C
ATOM	6835	CB	LYS	B	243	14.907	−108.518	−59.523	1.00	99.48	C
ATOM	6836	CG	LYS	B	243	16.296	−109.099	−59.763	1.00	100.34	C
ATOM	6837	CD	LYS	B	243	17.183	−108.147	−60.559	1.00	99.82	C
ATOM	6838	CE	LYS	B	243	18.658	−108.472	−60.379	1.00	100.33	C
ATOM	6839	NZ	LYS	B	243	19.086	−108.440	−58.948	1.00	100.66	N
ATOM	6840	C	LYS	B	243	13.460	−106.606	−58.748	1.00	106.09	C
ATOM	6841	O	LYS	B	243	13.254	−105.483	−59.220	1.00	111.67	O
ATOM	6842	N	SER	B	244	12.502	−107.366	−58.208	1.00	111.53	N
ATOM	6843	CA	SER	B	244	11.093	−106.933	−57.089	1.00	113.71	C
ATOM	6844	CB	SER	B	244	10.161	−108.133	−57.856	1.00	109.94	C
ATOM	6845	OG	SER	B	244	10.597	−108.927	−56.764	1.00	101.67	O
ATOM	6846	C	SER	B	244	10.882	−105.864	−57.008	1.00	108.68	C
ATOM	6847	O	SER	B	244	9.754	−105.407	−56.780	1.00	107.08	O
ATOM	6848	N	THR	B	245	11.981	−105.487	−56.350	1.00	102.97	N
ATOM	6849	CA	THR	B	245	12.048	−104.345	−55.428	1.00	99.95	C
ATOM	6850	CB	THR	B	245	12.533	−103.051	−56.171	1.00	93.88	C
ATOM	6851	OG1	THR	B	245	12.693	−101.973	−55.243	1.00	85.10	O
ATOM	6852	CG2	THR	B	245	11.590	−102.625	−57.324	1.00	91.37	C
ATOM	6853	C	THR	B	245	10.792	−104.169	−54.525	1.00	103.43	C
ATOM	6854	O	THR	B	245	10.228	−103.077	−54.382	1.00	104.33	O
ATOM	6855	N	SER	B	246	10.369	−105.283	−53.928	1.00	105.85	N
ATOM	6856	CA	SER	B	246	9.276	−105.303	−52.946	1.00	113.36	C
ATOM	6857	CB	SER	B	246	7.904	−105.167	−53.624	1.00	102.38	C
ATOM	6858	OG	SER	B	246	6.977	−104.344	−52.748	1.00	91.51	O
ATOM	6859	C	SER	B	246	9.331	−106.568	−52.069	1.00	111.88	C
ATOM	6860	O	SER	B	246	9.949	−107.574	−52.449	1.00	105.12	O
ATOM	6861	N	CYS	B	247	8.686	−106.502	−50.900	1.00	103.39	N
ATOM	6862	CA	CYS	B	247	8.718	−107.579	−49.905	1.00	109.16	C
ATOM	6863	CB	CYS	B	247	8.358	−107.051	−48.514	1.00	97.52	C
ATOM	6864	SG	CYS	B	247	9.574	−105.880	−47.868	1.00	105.12	S
ATOM	6865	C	CYS	B	247	7.790	−108.714	−50.287	1.00	95.97	C
ATOM	6866	O	CYS	B	247	6.587	−108.507	−50.465	1.00	89.37	O
ATOM	6867	N	VAL	B	248	8.364	−109.912	−50.407	1.00	93.90	N
ATOM	6868	CA	VAL	B	248	7.609	−111.084	−50.845	1.00	91.19	C
ATOM	6869	CB	VAL	B	248	8.437	−112.062	−51.764	1.00	94.15	C
ATOM	6870	CG1	VAL	B	248	9.581	−111.342	−52.477	1.00	90.77	C
ATOM	6871	CG2	VAL	B	248	8.975	−113.274	−51.018	1.00	91.25	C
ATOM	6872	C	VAL	B	248	6.919	−111.747	−49.641	1.00	89.74	C
ATOM	6873	O	VAL	B	248	5.691	−111.668	−49.506	1.00	89.01	O
ATOM	6874	N	LEU	B	249	7.708	−112.347	−48.753	1.00	81.63	N
ATOM	6875	CA	LEU	B	249	7.178	−113.071	−47.598	1.00	75.99	C
ATOM	6876	CB	LEU	B	249	7.627	−114.530	−47.649	1.00	73.75	C
ATOM	6877	CG	LEU	B	249	6.656	−115.608	−48.127	1.00	81.52	C
ATOM	6878	CD1	LEU	B	249	6.057	−115.296	−49.497	1.00	81.91	C
ATOM	6879	CD2	LEU	B	249	7.365	−116.956	−48.126	1.00	73.65	C
ATOM	6880	C	LEU	B	249	7.619	−112.451	−46.277	1.00	71.85	C
ATOM	6881	O	LEU	B	249	8.628	−111.744	−46.219	1.00	65.92	O
ATOM	6882	N	SER	B	250	6.858	−112.737	−45.221	1.00	71.59	N
ATOM	6883	CA	SER	B	250	7.163	−112.271	−43.871	1.00	69.11	C
ATOM	6884	CE	SER	B	250	6.689	−110.829	−43.674	1.00	71.29	C
ATOM	6885	OG	SER	B	250	5.272	−110.745	−43.679	1.00	74.14	O
ATOM	6886	C	SER	B	250	6.494	−113.169	−42.841	1.00	69.88	C
ATOM	6887	O	SER	B	250	5.409	−113.698	−43.071	1.00	70.66	O
ATOM	6888	N	SER	B	251	7.134	−113.324	−41.691	1.00	70.27	N
ATOM	6889	CA	SER	B	251	6.551	−114.099	−40.610	1.00	65.57	C
ATOM	6890	CB	SER	B	251	7.137	−115.508	−40.610	1.00	63.81	C
ATOM	6891	OG	SER	B	251	6.267	−116.429	−39.978	1.00	64.85	O
ATOM	6892	C	SER	B	251	6.828	−113.215	−39.275	1.00	63.43	C
ATOM	6893	O	SER	B	251	7.900	−112.832	−39.093	1.00	59.77	O
ATOM	6894	N	ALA	B	252	5.864	−113.290	−38.352	1.00	61.97	N
ATOM	6895	CA	ALA	B	252	6.097	−113.095	−36.948	1.00	62.07	C
ATOM	6896	CB	ALA	B	252	4.782	−112.143	−36.258	1.00	59.40	C
ATOM	6897	C	ALA	B	252	6.827	−114.219	−36.198	1.00	61.14	C
ATOM	6898	O	ALA	B	252	6.192	−115.119	−35.636	1.00	62.04	O
ATOM	6899	N	VAL	B	253	8.163	−114.170	−36.215	1.00	58.05	N
ATOM	6900	CA	VAL	B	253	9.000	−115.248	−35.670	1.00	50.85	C
ATOM	6901	CB	VAL	B	253	10.377	−115.336	−36.381	1.00	50.52	C
ATOM	6902	CG1	VAL	B	253	11.205	−116.526	−35.878	1.00	45.97	C
ATOM	6903	CG2	VAL	B	253	10.195	−115.429	−37.883	1.00	51.48	C
ATOM	6904	C	VAL	B	253	9.229	−115.041	−34.185	1.00	50.29	C
ATOM	6905	O	VAL	B	253	9.101	−115.974	−33.396	1.00	48.47	O
ATOM	6906	N	HIS	B	254	9.566	−113.811	−33.811	1.00	51.70	N
ATOM	6907	CA	HIS	B	254	9.976	−113.517	−32.447	1.00	51.57	C
ATOM	6908	CB	HIS	B	254	11.419	−113.041	−32.430	1.00	53.85	C
ATOM	6909	CG	HIS	B	254	12.415	−114.089	−32.816	1.00	53.34	C
ATOM	6910	ND1	HIS	B	254	12.767	−115.123	−31.979	1.00	54.14	N
ATOM	6911	CE1	HIS	B	254	13.694	−115.864	−32.562	1.00	53.54	C
ATOM	6912	NE2	HIS	B	254	13.968	−115.335	−33.740	1.00	52.26	N
ATOM	6913	CD2	HIS	B	254	13.185	−114.221	−33.921	1.00	50.52	C
ATOM	6914	C	HIS	B	254	9.109	−112.469	−31.769	1.00	52.73	C
ATOM	6915	O	HIS	B	254	8.413	−111.691	−32.432	1.00	53.45	O
ATOM	6916	N	SER	B	255	9.184	−112.457	−30.439	1.00	54.62	N
ATOM	6917	CA	SER	B	255	8.375	−111.592	−29.584	1.00	58.38	C
ATOM	6918	CB	SER	B	255	7.840	−112.381	−28.380	1.00	59.19	C
ATOM	6919	OG	SER	B	255	8.881	−112.718	−27.463	1.00	62.63	O
ATOM	6920	C	SER	B	255	9.203	−110.400	−29.106	1.00	61.62	C
ATOM	6921	O	SER	B	255	8.747	−109.593	−28.290	1.00	71.81	O
ATOM	6922	N	GLN	B	256	10.430	−110.320	−29.602	1.00	55.43	N
ATOM	6923	CA	GLN	B	256	11.331	−109.209	−29.339	1.00	54.99	C
ATOM	6924	CB	GLN	B	256	12.273	−109.502	−28.164	1.00	58.46	C
ATOM	6925	CG	GLN	B	256	11.611	−109.745	−26.814	1.00	62.71	C
ATOM	6926	CD	GLN	B	256	11.877	−108.632	−25.829	1.00	67.29	C
ATOM	6927	OE1	GLN	B	256	11.409	−107.509	−26.003	1.00	66.82	O
ATOM	6928	NE2	GLN	B	256	12.639	−108.538	−24.784	1.00	69.63	N
ATOM	6929	C	GLN	B	256	12.157	−109.026	−30.603	1.00	51.65	C
ATOM	6930	O	GLN	B	256	12.054	−109.807	−31.550	1.00	50.84	O
ATOM	6931	N	CYS	B	257	12.994	−108.007	−30.602	1.00	47.03	N
ATOM	6932	CA	CYS	B	257	13.787	−107.663	−31.761	1.00	51.10	C
ATOM	6933	CB	CYS	B	257	14.634	−106.458	−31.380	1.00	56.00	C
ATOM	6934	SG	CYS	B	257	16.378	−106.613	−31.699	1.00	68.39	S
ATOM	6935	C	CYS	B	257	14.632	−108.842	−32.316	1.00	49.77	C
ATOM	6936	O	CYS	B	257	15.156	−109.648	−31.547	1.00	47.59	O
ATOM	6937	N	VAL	B	258	14.721	−108.951	−33.645	1.00	45.92	N
ATOM	6938	CA	VAL	B	258	15.546	−109.974	−34.324	1.00	46.44	C
ATOM	6939	CB	VAL	B	258	14.946	−110.354	−35.697	1.00	44.64	C
ATOM	6940	CG1	VAL	B	258	15.716	−111.511	−36.312	1.00	43.04	C
ATOM	6941	CG2	VAL	B	258	13.461	−110.701	−35.567	1.00	44.78	C
ATOM	6942	C	VAL	B	258	16.994	−109.495	−34.541	1.00	48.83	C
ATOM	6943	O	VAL	B	258	17.254	−108.689	−35.437	1.00	53.78	O
ATOM	6944	N	THR	B	259	17.931	−109.986	−33.735	1.00	50.45	N
ATOM	6945	CA	THR	B	259	19.323	−109.484	−33.780	1.00	55.42	C
ATOM	6946	CB	THR	B	259	19.999	−109.506	−32.389	1.00	58.87	C
ATOM	6947	OG1	THR	B	259	19.557	−110.657	−31.662	1.00	60.13	O
ATOM	6948	CG2	THR	B	259	19.654	−108.229	−31.592	1.00	59.10	C
ATOM	6949	C	THR	B	259	20.255	−110.158	−34.800	1.00	53.34	C
ATOM	6950	O	THR	B	259	21.277	−109.583	−35.184	1.00	56.21	O
ATOM	6951	N	GLY	B	260	19.918	−111.368	−35.229	1.00	50.40	N
ATOM	6952	CA	GLY	B	260	20.735	−112.042	−36.225	1.00	48.80	C
ATOM	6953	C	GLY	B	260	19.994	−113.015	−37.114	1.00	49.37	C
ATOM	6954	O	GLY	B	260	19.029	−113.673	−36.681	1.00	49.37	O
ATOM	6955	N	LEU	B	261	20.449	−113.099	−38.364	1.00	48.56	N
ATOM	6956	CA	LEU	B	261	19.909	−114.059	−39.333	1.00	50.14	C
ATOM	6957	CB	LEU	B	261	18.964	−113.360	−40.307	1.00	46.11	C
ATOM	6958	CG	LEU	B	261	17.707	−112.709	−39.712	1.00	44.38	C
ATOM	6959	CD1	LEU	B	261	17.168	−111.620	−40.630	1.00	42.83	C
ATOM	6960	CD2	LEU	B	261	16.639	−113.753	−39.411	1.00	45.14	C
ATOM	6961	C	LEU	B	261	21.038	−114.798	−40.081	1.00	54.62	C
ATOM	6962	O	LEU	B	261	21.886	−114.176	−40.742	1.00	53.73	O
ATOM	6963	N	VAL	B	262	21.054	−116.124	−39.951	1.00	54.69	N
ATOM	6964	CA	VAL	B	262	22.133	−116.942	−40.509	1.00	59.88	C
ATOM	6965	CB	VAL	B	262	23.060	−117.515	−39.405	1.00	56.78	C
ATOM	6966	CG1	VAL	B	262	24.209	−118.277	−40.028	1.00	48.91	C
ATOM	6967	CG2	VAL	B	262	23.592	−116.414	−38.491	1.00	53.30	C
ATOM	6968	C	VAL	B	262	21.583	−118.096	−41.355	1.00	63.67	C
ATOM	6969	O	VAL	B	262	20.852	−118.958	−40.852	1.00	61.69	O
ATOM	6970	N	PHE	B	263	21.946	−118.104	−42.639	1.00	64.33	N
ATOM	6971	CA	PHE	B	263	21.582	−119.193	−43.551	1.00	61.04	C
ATOM	6972	CB	PHE	B	263	21.601	−118.710	−45.007	1.00	56.53	C
ATOM	6973	CG	PHE	B	263	20.366	−117.964	−45.422	1.00	49.58	C
ATOM	6974	CD1	PHE	B	263	19.140	−118.620	−45.543	1.00	50.36	C
ATOM	6975	CE1	PHE	B	263	17.990	−117.924	−45.939	1.00	48.09	C
ATOM	6976	CZ	PHE	B	263	18.062	−116.563	−46.218	1.00	44.10	C
ATOM	6977	CE2	PHE	B	263	19.280	−115.902	−46.104	1.00	46.05	C
ATOM	6978	CD2	PHE	B	263	20.423	−116.604	−45.710	1.00	48.96	C
ATOM	6979	C	PHE	B	263	22.500	−120.408	−43.385	1.00	59.97	C
ATOM	6980	O	PHE	B	263	23.704	−120.264	−43.159	1.00	62.68	O
ATOM	6981	N	SER	B	264	21.925	−121.604	−43.498	1.00	62.69	N
ATOM	6982	CA	SER	B	264	22.705	−122.842	−43.424	1.00	63.75	C
ATOM	6983	CB	SER	B	264	21.787	−124.039	−43.152	1.00	65.30	C
ATOM	6984	OG	SER	B	264	21.044	−124.393	−44.255	1.00	64.51	O
ATOM	6985	C	SER	B	264	23.529	−123.065	−44.699	1.00	69.70	C
ATOM	6986	O	SER	B	264	23.239	−122.454	−45.735	1.00	57.05	O
ATOM	6987	N	PRO	B	265	24.558	−123.934	−44.628	1.00	63.73	N
ATOM	6988	CA	PRO	B	265	25.349	−124.248	−45.829	1.00	67.47	C
ATOM	6989	CB	PRO	B	265	26.625	−124.907	−45.263	1.00	64.33	C
ATOM	6990	CG	PRO	B	265	26.574	−124.710	−43.777	1.00	63.19	C
ATOM	6991	CD	PRO	B	265	25.114	−124.598	−43.437	1.00	63.78	C
ATOM	6992	C	PRO	B	265	24.634	−125.194	−46.820	1.00	71.48	C
ATOM	6993	O	PRO	B	265	25.042	−125.269	−47.981	1.00	63.39	O
ATOM	6994	N	HIS	B	266	23.587	−125.891	−46.359	1.00	75.64	N
ATOM	6995	CA	HIS	B	266	22.714	−126.753	−47.190	1.00	75.31	C
ATOM	6996	CB	HIS	B	266	21.360	−126.965	−46.496	1.00	73.92	C
ATOM	6997	CG	HIS	B	266	21.436	−127.768	−45.234	1.00	83.03	C
ATOM	6998	ND1	HIS	B	266	21.033	−129.084	−45.166	1.00	85.03	N
ATOM	6999	CE1	HIS	B	266	21.204	−129.534	−43.935	1.00	85.44	C
ATOM	7000	NE2	HIS	B	266	21.699	−128.555	−43.201	1.00	83.64	N
ATOM	7001	CE2	HIS	B	266	21.857	−127.440	−43.990	1.00	87.51	C
ATOM	7002	C	HIS	B	266	22.431	−126.254	−48.612	1.00	83.06	C
ATOM	7003	O	HIS	B	266	22.432	−125.036	−48.867	1.00	83.46	O
ATOM	7004	N	SER	B	267	22.157	−127.206	−49.516	1.00	84.83	N
ATOM	7005	CA	SER	B	267	21.780	−126.917	−50.913	1.00	82.97	C
ATOM	7006	CB	SER	B	267	21.452	−128.206	−51.677	1.00	81.45	C
ATOM	7007	OG	SER	B	267	22.628	−128.825	−52.159	1.00	73.15	O
ATOM	7008	C	SER	B	267	20.606	−125.944	−50.985	1.00	89.96	C
ATOM	7009	O	SER	B	267	20.748	−124.824	−51.485	1.00	73.52	O
ATOM	7010	N	VAL	B	268	19.447	−126.378	−50.496	1.00	81.45	N
ATOM	7011	CA	VAL	B	268	18.347	−125.453	−50.223	1.00	83.90	C
ATOM	7012	CB	VAL	B	268	16.973	−126.019	−50.668	1.00	85.21	C
ATOM	7013	CG1	VAL	B	268	16.732	−127.423	−50.106	1.00	91.60	C
ATOM	7014	CG2	VAL	B	268	15.836	−125.050	−50.335	1.00	85.13	C
ATOM	7015	C	VAL	B	268	18.445	−125.085	−48.728	1.00	81.84	C
ATOM	7016	O	VAL	B	268	18.232	−125.938	−47.856	1.00	79.42	O
ATOM	7017	N	PRO	B	269	18.805	−123.818	−48.430	1.00	77.70	N
ATOM	7018	CA	PRO	B	269	19.321	−123.516	−47.104	1.00	75.82	C
ATOM	7019	CB	PRO	B	269	20.235	−122.311	−47.354	1.00	73.15	C
ATOM	7020	CG	PRO	B	269	19.793	−121.729	−48.665	1.00	75.81	C
ATOM	7021	CD	PRO	B	269	18.697	−122.592	−49.238	1.00	77.47	C
ATOM	7022	C	PRO	B	269	18.256	−123.168	−46.072	1.00	73.40	C
ATOM	7023	O	PRO	B	269	17.209	−122.600	−46.410	1.00	71.41	O
ATOM	7024	N	PHE	B	270	18.546	−123.536	−44.826	1.00	68.59	N
ATOM	7025	CA	PHE	B	270	17.748	−123.151	−43.672	1.00	67.87	C
ATOM	7026	CB	PHE	B	270	17.872	−124.190	−42.560	1.00	69.00	C
ATOM	7027	CG	PHE	B	270	17.433	−125.563	−42.960	1.00	74.77	C
ATOM	7028	CD1	PHE	B	270	16.085	−125.861	−43.103	1.00	75.44	C
ATOM	7029	CE1	PHE	B	270	15.683	−127.132	−43.472	1.00	81.93	C
ATOM	7030	CZ	PHE	B	270	16.633	−128.120	−43.694	1.00	83.83	C
ATOM	7031	CE2	PHE	B	270	17.982	−127.835	−43.555	1.00	75.59	C
ATOM	7032	CD2	PHE	B	270	18.374	−126.564	−43.190	1.00	75.90	C
ATOM	7033	C	PHE	B	270	18.239	−121.813	−43.148	1.00	63.63	C
ATOM	7034	O	PHE	B	270	19.401	−121.453	−43.348	1.00	66.16	O
ATOM	7035	N	LEU	B	271	17.347	−121.098	−42.468	1.00	60.91	N
ATOM	7036	CA	LEU	B	271	17.648	−119.796	−41.899	1.00	56.42	C
ATOM	7037	CB	LEU	B	271	16.699	−118.749	−42.463	1.00	54.17	C
ATOM	7038	CG	LEU	B	271	16.955	−117.339	−41.945	1.00	54.00	C
ATOM	7039	CD1	LEU	B	271	18.336	−116.904	−42.412	1.00	50.39	C
ATOM	7040	CD2	LEU	B	271	15.875	−116.152	−42.385	1.00	46.59	C
ATOM	7041	C	LEU	B	271	17.497	−119.834	−40.393	1.00	56.83	C
ATOM	7042	O	LEU	B	271	16.401	−120.060	−39.878	1.00	56.65	O
ATOM	7043	N	ALA	B	272	18.610	−119.628	−39.695	1.00	55.31	N
ATOM	7044	CA	ALA	B	272	18.607	−119.457	−38.250	1.00	52.09	C
ATOM	7045	CB	ALA	B	272	19.972	−119.774	−37.680	1.00	48.67	C
ATOM	7046	C	ALA	B	272	18.197	−118.019	−37.903	1.00	55.12	C
ATOM	7047	O	ALA	B	272	18.675	−117.647	−38.495	1.00	50.38	O
ATOM	7048	N	SER	B	273	17.287	−117.502	−36.945	1.00	59.82	N
ATOM	7049	CA	SER	B	273	16.788	−116.613	−36.497	1.00	62.85	C
ATOM	7050	CB	SER	B	273	15.295	−116.508	−36.806	1.00	62.34	C
ATOM	7051	OG	SER	B	273	14.847	−115.175	−36.675	1.00	70.42	O
ATOM	7052	C	SER	B	273	17.038	−116.494	−34.994	1.00	59.97	C
ATOM	7053	O	SER	B	273	16.632	−117.370	−34.219	1.00	61.35	O
ATOM	7054	N	LEU	B	274	17.724	−115.432	−34.585	1.00	53.66	N
ATOM	7055	CA	LEU	B	274	18.043	−115.248	−33.168	1.00	50.50	C
ATOM	7056	CB	LEU	B	274	19.523	−115.489	−32.885	1.00	47.11	C
ATOM	7057	CG	LEU	B	274	20.524	−114.676	−33.692	1.00	46.74	C
ATOM	7058	CD1	LEU	B	274	21.585	−114.125	−32.771	1.00	47.85	C
ATOM	7059	CD2	LEU	B	274	21.164	−115.520	−34.772	1.00	46.89	C
ATOM	7060	C	LEU	B	274	17.583	−113.897	−32.623	1.00	51.49	C
ATOM	7061	O	LEU	B	274	17.612	−112.886	−33.320	1.00	52.42	O
ATOM	7062	N	SER	B	275	17.164	−113.889	−31.361	1.00	53.45	N
ATOM	7063	CA	SER	B	275	16.438	−112.753	−30.821	1.00	51.27	C
ATOM	7064	CB	SER	B	275	14.936	−112.976	−31.022	1.00	49.79	C
ATOM	7065	OG	SER	B	275	14.179	−111.961	−30.403	1.00	50.15	O
ATOM	7066	C	SER	B	275	16.724	−112.444	−29.355	1.00	51.05	C
ATOM	7067	O	SER	B	275	17.184	−113.296	−28.592	1.00	50.80	O
ATOM	7068	N	GLU	B	276	16.424	−111.203	−28.978	1.00	49.86	N
ATOM	7069	CA	GLU	B	276	16.444	−110.770	−27.590	1.00	46.14	C
ATOM	7070	CB	GLU	B	276	16.318	−109.252	−27.509	1.00	48.16	C
ATOM	7071	CG	GLU	B	276	17.585	−108.518	−27.919	1.00	48.40	C
ATOM	7072	CD	GLU	B	276	17.459	−107.006	−27.902	1.00	53.03	C
ATOM	7073	OE1	GLU	B	276	16.448	−106.467	−27.388	1.00	53.65	O
ATOM	7074	OE2	GLU	B	276	18.397	−106.348	−28.405	1.00	56.60	O
ATOM	7075	C	GLU	B	276	15.344	−111.449	−26.770	1.00	45.44	C
ATOM	7075	O	GLU	B	276	15.358	−111.375	−25.538	1.00	43.62	O
ATOM	7077	N	ASP	B	277	14.406	−112.131	−27.432	1.00	43.21	N
ATOM	7078	CA	ASP	B	277	13.460	−112.961	−26.674	1.00	46.85	C
ATOM	7079	CB	ASP	B	277	12.189	−113.298	−27.468	1.00	45.86	C
ATOM	7080	CG	ASP	B	277	12.426	−114.311	−28.561	1.00	50.97	C
ATOM	7081	OD1	ASP	B	277	13.553	−114.870	−28.659	1.00	50.06	O
ATOM	7082	OD2	ASP	B	277	11.465	−114.548	−29.329	1.00	50.17	O
ATOM	7083	C	ASP	B	277	14.134	−114.224	−26.138	1.00	50.02	C
ATOM	7084	O	ASP	B	277	13.469	−115.091	−25.568	1.00	50.76	O
ATOM	7085	N	CYS	B	278	15.453	−114.321	−26.343	1.00	50.54	N
ATOM	7086	CA	CYS	B	278	16.278	−115.361	−25.7361	1.00	47.79	C
ATOM	7087	CB	CYS	B	278	15.925	−115.523	−24.254	1.00	49.58	C
ATOM	7088	SG	CYS	B	278	16.583	−114.211	−23.206	1.00	51.58	S
ATOM	7089	C	CYS	B	278	16.130	−116.694	−26.439	1.00	48.40	C
ATOM	7090	O	CYS	B	278	16.607	−117.706	−25.945	1.00	55.76	O
ATOM	7091	N	SER	B	279	15.476	−116.696	−27.593	1.00	46.32	N
ATOM	7092	CA	SER	B	279	15.237	−117.927	−28.314	1.00	47.21	C
ATOM	7093	CB	SER	B	279	13.727	−118.142	−28.540	1.00	46.97	C
ATOM	7094	OG	SER	B	279	13.250	−117.388	−29.652	1.00	45.25	O
ATOM	7095	C	SER	B	279	15.982	−117.991	−29.650	1.00	45.71	C
ATOM	7096	O	SER	B	279	16.296	−116.981	−30.257	1.00	45.19	C
ATOM	7097	N	LEU	B	280	16.247	−119.210	−30.095	1.00	49.75	N
ATOM	7098	CA	LEU	B	280	16.672	−119.481	−31.458	1.00	47.47	C
ATOM	7099	CB	LEU	B	280	17.897	−120.423	−31.466	1.00	46.54	C
ATOM	7100	CG	LEU	B	280	18.150	−121.337	−32.683	1.00	45.50	C
ATOM	7101	CD1	LEU	B	280	18.524	−120.569	−33.934	1.00	41.10	C
ATOM	7102	CD2	LEU	B	280	19.228	−122.353	−32.364	1.00	49.87	C
ATOM	7103	C	LEU	B	280	15.507	−120.108	−32.213	1.00	46.68	C
ATOM	7104	O	LEU	B	280	14.743	−120.912	−31.657	1.00	51.00	O
ATOM	7105	N	ALA	B	281	15.356	−119.721	−33.468	1.00	45.19	N
ATOM	7106	CA	ALA	B	281	14.421	−120.407	−34.356	1.00	52.56	C
ATOM	7107	CB	ALA	B	281	13.167	−119.575	−34.575	1.00	52.46	C
ATOM	7108	C	ALA	B	281	15.089	−120.740	−35.686	1.00	52.88	C
ATOM	7109	O	ALA	B	281	16.003	−120.038	−36.125	1.00	56.40	O
ATOM	7110	N	VAL	B	282	14.043	−121.626	−36.309	1.00	55.57	N
ATOM	7111	CA	VAL	B	282	15.147	−122.227	−37.618	1.00	54.40	C
ATOM	7112	CB	VAL	B	282	15.949	−123.544	−37.557	1.00	55.94	C
ATOM	7113	CG1	VAL	B	282	16.279	−124.038	−38.962	1.00	54.62	C
ATOM	7114	CG2	VAL	B	282	17.226	−123.352	−36.741	1.00	53.67	C
ATOM	7115	C	VAL	B	282	13.977	−122.339	−38.586	1.00	56.51	C
ATOM	7116	O	VAL	B	282	12.979	−123.032	−38.314	1.00	58.40	O
ATOM	7117	N	LEU	B	283	14.118	−121.646	−39.713	1.00	54.10	N
ATOM	7118	CA	LEU	B	283	13.064	−121.536	−40.704	1.00	58.13	C
ATOM	7119	CB	LEU	B	283	12.646	−120.070	−40.855	1.00	54.66	C
ATOM	7120	CG	LEU	B	283	12.579	−119.264	−39.557	1.00	51.52	C
ATOM	7121	CD1	LEU	B	283	12.886	−117.798	−39.824	1.00	50.12	C
ATOM	7122	CD2	LEU	B	283	11.239	−119.458	−38.864	1.00	46.58	C
ATOM	7123	C	LEU	B	283	13.523	−122.065	−42.055	1.00	63.48	C
ATOM	7124	O	LEU	B	283	14.722	−122.029	−42.381	1.00	64.78	O
ATOM	7125	N	ASP	B	284	12.560	−122.542	−42.839	1.00	64.15	N
ATOM	7126	CA	ASP	B	284	12.823	−122.975	−44.211	1.00	67.77	C
ATOM	7127	CB	ASP	B	284	11.848	−124.078	−44.631	1.00	67.86	C
ATOM	7128	CG	ASP	B	284	10.391	−123.664	−44.482	1.00	67.69	C
ATOM	7129	OD1	ASP	B	284	10.033	−122.518	−44.851	1.00	69.00	O
ATOM	7130	OD2	ASP	B	284	9.605	−124.495	−43.993	1.00	65.68	O
ATOM	7131	C	ASP	B	284	12.747	−121.806	−45.193	1.00	68.67	C
ATOM	7132	O	ASP	B	284	12.651	−120.638	−44.785	1.00	65.40	O
ATOM	7133	N	SER	B	285	12.767	−122.143	−46.485	1.00	68.90	N
ATOM	7134	CA	SER	B	285	12.762	−121.161	−47.566	1.00	69.65	C
ATOM	7135	CB	SER	B	285	12.802	−121.869	−48.922	1.00	69.04	C
ATOM	7136	OG	SER	B	285	11.640	−122.657	−49.109	1.00	68.13	O
ATOM	7137	C	SER	B	285	11.544	−120.238	−47.506	1.00	68.00	C
ATOM	7138	O	SER	B	285	11.637	−119.068	−47.867	1.00	65.95	O
ATOM	7139	N	SER	B	286	10.415	−120.773	−47.048	1.00	62.57	N
ATOM	7140	CA	SER	B	286	9.162	−120.031	−47.038	1.00	63.52	C
ATOM	7141	CB	SER	B	286	8.004	−120.954	−47.424	1.00	66.13	C
ATOM	7142	OG	SER	B	286	7.696	−121.347	−46.361	1.00	69.98	O
ATOM	7143	C	SER	B	286	8.891	−119.166	−45.682	1.00	61.46	C
ATOM	7144	O	SER	B	286	7.793	−118.871	−45.431	1.00	57.05	O
ATOM	7145	N	LEU	B	287	9.903	−119.158	−44.816	1.00	66.81	N
ATOM	7146	CA	LEU	B	287	9.829	−118.705	−43.493	1.00	66.82	C
ATOM	7147	CB	LEU	B	287	9.430	−117.118	−43.620	1.00	61.35	C
ATOM	7148	CG	LEU	B	287	10.510	−116.145	−43.835	1.00	57.80	C
ATOM	7149	CD1	LEU	B	287	11.741	−116.616	−44.596	1.00	58.11	C
ATOM	7150	CD2	LEU	B	787	9.908	−114.932	−44.516	1.00	58.51	C
ATOM	7151	C	LEU	B	287	8.921	−119.440	−42.505	1.00	68.22	C
ATOM	7152	O	LEU	B	287	8.461	−118.863	−41.516	1.00	70.14	O
ATOM	7153	N	SER	B	288	8.680	−120.717	−42.778	1.00	65.37	N
ATOM	7154	CA	SER	B	288	7.903	−121.558	−41.886	1.00	68.93	C
ATOM	7155	CB	SER	B	288	7.219	−122.863	−42.689	1.00	67.89	C
ATOM	7156	OG	SER	B	288	5.868	−122.803	−42.307	1.00	69.13	O
ATOM	7157	C	SER	B	288	8.818	−122.136	−40.795	1.00	68.12	C
ATOM	7158	O	SER	B	288	10.012	−122.166	−41.027	1.00	69.43	O
ATOM	7159	N	GLU	B	289	8.263	−122.161	−39.608	1.00	66.86	N
ATOM	7160	CA	GLU	B	289	9.072	−122.765	−38.460	1.00	69.71	C
ATOM	7161	CB	GLU	B	289	8.438	−122.289	−37.142	1.00	70.97	C
ATOM	7162	CG	GLU	B	289	9.294	−122.557	−35.906	1.00	73.55	C
ATOM	7163	CD	GLU	B	289	8.622	−122.118	−34.580	1.00	74.44	C
ATOM	7164	OE1	GLU	B	289	7.800	−121.276	−34.517	1.00	70.37	O
ATOM	7165	OE2	GLU	B	289	8.944	−122.190	−33.574	1.00	77.32	O
ATOM	7166	C	GLU	B	289	9.315	−124.178	−38.436	1.00	69.85	C
ATOM	7167	O	GLU	B	289	8.374	−125.971	−38.412	1.00	69.92	O
ATOM	7168	N	LEU	B	290	10.588	−124.861	−38.442	1.00	68.55	N
ATOM	7169	CA	LEU	B	290	10.993	−126.063	−38.331	1.00	68.20	C
ATOM	7170	CB	LEU	B	290	12.135	−126.367	−39.308	1.00	74.77	C
ATOM	7171	CG	LEU	B	290	11.866	−127.149	−40.595	1.00	81.50	C
ATOM	7172	CD1	LEU	B	290	11.420	−126.250	−41.741	1.00	79.58	C
ATOM	7173	CD2	LEU	B	290	13.127	−127.509	−40.985	1.00	90.47	C
ATOM	7174	C	LEU	B	290	11.459	−126.415	−36.919	1.00	65.96	C
ATOM	7175	O	LEU	B	290	11.279	−127.347	−36.463	1.00	61.05	O
ATOM	7176	N	PHE	B	291	12.070	−125.444	−36.243	1.00	62.75	N
ATOM	7177	CA	PHE	B	291	12.714	−12.861	−34.953	1.00	62.28	C
ATOM	7178	CB	PHE	B	291	14.185	−126.041	−35.185	1.00	59.06	C
ATOM	7179	CG	PHE	B	291	14.924	−126.115	−33.951	1.00	58.67	C
ATOM	7180	CD1	PHE	B	291	14.458	−127.191	−33.193	1.00	60.75	C
ATOM	7181	CE1	PHE	B	291	15.165	−128.038	−32.074	1.00	62.50	C
ATOM	7182	CZ	PHE	B	291	16.360	−127.422	−31.712	1.00	60.46	C
ATOM	7183	CE2	PHE	B	291	16.842	−126.155	−32.466	1.00	58.21	C
ATOM	7184	CD2	PHE	B	291	16.131	−125.916	−33.579	1.00	57.81	C
ATOM	7185	C	PHE	B	291	12.609	−124.390	−34.107	1.00	66.10	C
ATOM	7186	O	PHE	B	291	12.329	−123.303	−34.622	1.00	67.99	O
ATOM	7187	N	ARG	B	292	12.823	−124.346	−32.802	1.00	66.87	N
ATOM	7188	CA	ARG	B	292	12.856	−123.440	−31.854	1.00	61.13	C
ATOM	7189	CB	ARG	B	292	11.429	−122.589	−31.508	1.00	66.67	C
ATOM	7190	CG	ARG	B	292	11.305	−121.953	−30.403	1.00	61.82	C
ATOM	7191	CD	ARG	B	292	10.095	−121.071	−30.641	1.00	64.27	C
ATOM	7192	NE	ARG	B	292	10.514	−119.115	−30.981	1.00	65.15	N
ATOM	7193	CZ	ARG	B	292	10.238	−119.089	−32.120	1.00	57.70	C
ATOM	7194	NH1	ARG	B	292	10.680	−117.865	−32.302	1.00	55.38	N
ATOM	7195	NH2	ARG	B	292	9.514	−119.668	−33.063	1.00	58.53	N
ATOM	7196	C	ARG	B	292	13.587	−123.533	−30.624	1.00	60.18	C
ATOM	7197	O	ARG	B	292	13.356	−1265.050	−30.176	1.00	61.77	O
ATOM	7198	N	SER	B	293	14.486	−123.112	−30.089	1.00	62.62	N
ATOM	7199	CA	SER	B	293	15.203	−123.473	−28.862	1.00	57.85	C
ATOM	7200	CB	SER	B	293	16.628	−123.816	−29.177	1.00	51.43	C
ATOM	7201	OG	SER	B	293	17.311	−124.252	−27.983	1.00	48.58	O
ATOM	7202	C	SER	B	293	15.224	−122.381	−27.786	1.00	59.30	C
ATOM	7203	O	SER	B	293	15.706	−121.266	−28.011	1.00	61.97	O
ATOM	7204	N	GLN	B	294	14.715	−122.730	−26.611	1.00	60.15	N
ATOM	7205	CA	GLN	B	294	14.810	−121.891	−25.434	1.00	58.52	C
ATOM	7206	CB	GLN	B	294	13.554	−122.039	−24.580	1.00	60.78	C
ATOM	7207	CS	GLN	B	294	12.506	−120.968	−24.825	1.00	69.29	C
ATOM	7208	CD	GLN	B	294	11.481	−121.383	−25.848	1.00	72.78	C
ATOM	7209	OE1	GLN	B	294	10.830	−122.418	−25.705	1.00	78.23	O
ATOM	7210	NE2	GLN	B	294	11.322	−120.573	−26.885	1.00	74.79	N
ATOM	7211	C	GLN	B	294	16.042	−122.203	−24.582	1.00	58.03	C
ATOM	7212	O	GLN	B	294	16.152	−121.724	−23.453	1.00	57.21	O
ATOM	7213	N	ALA	B	295	16.969	−122.996	−25.111	1.00	55.53	N
ATOM	7214	CA	ALA	B	295	18.171	−123.380	−24.353	1.00	58.30	C
ATOM	7215	CB	ALA	B	295	19.168	−124.065	−25.261	1.00	55.38	C
ATOM	7216	C	ALA	B	295	18.846	−122.206	−23.645	1.00	57.69	C
ATOM	7217	O	ALA	B	295	19.459	−122.361	−22.575	1.00	51.39	O
ATOM	7218	N	HIS	B	296	18.750	−121.029	−24.251	1.00	59.48	N
ATOM	7219	CA	HIS	B	296	19.381	−119.858	−23.661	1.00	60.91	C
ATOM	7220	CB	HIS	B	296	19.782	−118.863	−24.737	1.00	55.79	C
ATOM	7221	CG	HIS	B	296	21.097	−119.175	−25.366	1.1.00	58.58	C
ATOM	7222	ND1	HIS	B	296	22.290	−119.079	−24.681	1.00	60.13	N
ATOM	7223	CE1	HIS	B	296	23.285	−119.403	−25.486	1.00	56.70	C
ATOM	7224	NE2	HIS	B	296	22.781	−119.712	−26.667	1.00	55.91	N
ATOM	7225	CD2	HIS	B	296	21.412	−119.586	−26.616	1.00	59.19	C
ATOM	7226	C	HIS	B	296	18.491	−119.208	−22.618	1.00	60.84	C
ATOM	7227	O	HIS	B	296	17.258	−119.281	−22.704	1.00	56.96	O
ATOM	7228	N	ARG	B	297	19.123	−118.591	−21.624	1.00	58.38	N
ATOM	7229	CA	ARG	B	297	18.376	−117.865	−20.604	1.00	62.80	C
ATOM	7230	CB	ARG	B	297	18.431	−118.598	−19.257	1.00	66.50	C
ATOM	7231	CG	ARG	B	297	19.834	−118.784	−18.719	1.00	76.98	C
ATOM	7232	CD	ARG	B	297	19.923	−119.918	−17.711	1.00	83.38	C
ATOM	7233	NE	ARG	B	297	21.326	−120.139	−17.369	1.00	89.38	N
ATOM	7234	CZ	ARG	B	297	22.046	−121.183	−17.770	1.00	89.10	C
ATOM	7235	NH1	ARG	B	297	21.492	−122.139	−18.508	1.00	85.46	N
ATOM	7236	NH2	ARG	B	297	23.323	−121.275	−17.421	1.00	85.05	N
ATOM	7237	C	ARG	B	297	18.802	−116.386	−20.511	1.00	60.97	C
ATOM	7238	O	ARG	B	297	18.538	−115.705	−19.519	1.00	60.68	O
ATOM	7239	N	ASP	B	298	19.459	−115.910	−21.566	1.00	53.96	N
ATOM	7240	CA	ASP	B	298	19.701	−114.487	−21.788	1.00	49.71	C
ATOM	7241	CB	ASP	B	298	20.995	−114.022	−21.126	1.00	49.80	C
ATOM	7242	CG	ASP	B	298	20.972	−112.537	−20.808	1.00	50.56	C
ATOM	7243	OD1	ASP	B	298	20.075	−111.826	−21.313	1.00	50.90	O
ATOM	7244	OD2	ASP	B	298	21.845	−112.075	−20.051	1.00	53.54	O
ATOM	7245	C	ASP	B	298	19.726	−114.251	−23.299	1.00	46.39	C
ATOM	7246	O	ASP	B	298	19.504	−115.201	−24.040	1.00	47.43	O
ATOM	7247	N	PHE	B	299	19.971	−113.016	−23.764	1.00	44.74	N
ATOM	7248	CA	PHE	B	299	20.023	−112.738	−25.219	1.00	45.19	C
ATOM	7249	CB	PHE	B	299	20.516	−111.323	−25.550	1.00	42.44	C
ATOM	7250	CG	PHE	B	299	19.675	−110.201	−24.980	1.00	41.78	C
ATOM	7251	CD1	PHE	B	299	18.351	−110.393	−24.596	1.00	42.08	C
ATOM	7252	CE1	PHE	B	299	17.600	−109.335	−24.090	1.00	41.31	C
ATOM	7253	CZ	PHE	B	299	18.164	−108.068	−23.977	1.00	39.17	C
ATOM	7254	CE2	PHE	B	299	19.472	−107.858	−24.372	1.00	37.06	C
ATOM	7255	CD2	PHE	B	299	20.212	−108.911	−24.883	1.00	40.49	C
ATOM	7256	C	PHE	B	299	20.888	−113.742	−25.976	1.00	45.56	C
ATOM	7257	O	PHE	B	299	21.929	−114.166	−25.474	1.00	49.81	O
ATOM	7258	N	VAL	B	300	20.423	−114.132	−27.164	1.00	48.82	N
ATOM	7259	CA	VAL	B	300	21.184	−114.963	−28.111	1.00	45.02	C
ATOM	7260	CB	VAL	B	300	20.279	−115.920	−28.916	1.00	45.94	C
ATOM	7261	CG1	VAL	B	300	21.141	−116.905	−29.684	1.00	47.60	C
ATOM	7262	CG2	VAL	B	300	19.294	−116.666	−28.019	1.00	43.45	C
ATOM	7263	C	VAL	B	300	21.859	−114.033	−29.110	1.00	44.62	C
ATOM	7264	O	VAL	B	300	21.188	−113.354	−29.866	1.00	44.64	O
ATOM	7265	N	ARG	B	301	23.182	−114.017	−29.126	1.00	43.62	N
ATOM	7266	CA	ARG	B	301	23.909	−113.059	−29.938	1.00	44.35	C
ATOM	7267	CB	ARG	B	301	25.072	−112.129	−29.127	1.00	46.69	C
ATOM	7268	CG	ARG	B	301	24.606	−111.888	−27.837	1.00	51.57	C
ATOM	7269	CD	ARG	B	301	24.413	−110.197	−28.049	1.00	51.74	C
ATOM	7270	NE	ARG	B	301	23.048	−110.921	−28.379	1.00	50.59	N
ATOM	7271	CZ	ARG	B	301	22.707	−108.831	−28.865	1.00	50.22	C
ATOM	7272	NH1	ARG	B	301	23.630	−107.909	−29.107	1.00	42.14	N
ATOM	7273	NH2	ARG	B	301	21.432	−108.370	−29.113	1.00	54.50	N
ATOM	7274	C	ARG	B	301	24.388	−113.141	−31.308	1.00	46.93	C
ATOM	7275	O	ARG	B	301	24.503	−112.747	−32.239	1.00	51.07	O
ATOM	7276	N	ASP	B	302	24.684	−114.829	−31.445	1.00	50.52	N
ATOM	7277	CA	ASP	B	302	25.162	−115.334	−32.729	1.00	51.37	C
ATOM	7278	CB	ASP	B	302	26.686	−115.231	−32.814	1.00	50.82	C
ATOM	7279	CG	ASP	B	302	27.170	−114.147	−34.205	1.00	53.02	C
ATOM	7280	OD1	ASP	B	302	26.338	−114.809	−35.146	1.00	52.57	O
ATOM	7281	OD2	ASP	B	302	28.378	−114.558	−34.351	1.00	49.56	O
ATOM	7282	C	ASP	B	302	24.702	−116.753	−33.035	1.00	53.50	C
ATOM	7283	O	ASP	B	302	24.182	−117.451	−32.163	1.00	51.95	O
ATOM	7284	N	ALA	B	303	24.871	−117.154	−34.295	1.00	56.36	N
ATOM	7285	CA	ALA	B	303	24.748	−118.551	−34.704	1.00	57.12	C
ATOM	7286	CB	ALA	B	303	23.333	−118.142	−35.164	1.00	54.66	C
ATOM	7287	C	ALA	B	303	25.748	−118.182	−35.820	1.00	58.75	C
ATOM	7288	O	ALA	B	303	25.972	−118.058	−36.712	1.00	63.90	O
ATOM	7289	N	THR	B	304	26.363	−120.068	−35.752	1.00	57.93	N
ATOM	7290	CA	THR	B	304	27.060	−120.063	−36.916	1.00	52.16	C
ATOM	7291	CB	THR	B	304	28.595	−120.149	−36.897	1.00	47.51	C
ATOM	7292	OG1	THR	B	304	29.053	−120.361	−35.559	1.00	49.54	O
ATOM	7293	CG2	THR	B	304	29.044	−119.399	−37.768	1.00	51.09	C
ATOM	7294	C	THR	B	304	26.698	−122.109	−37.130	1.00	50.22	C
ATOM	7295	O	THR	B	304	26.459	−122.870	−36.190	1.00	47.05	O
ATOM	7296	N	TRP	B	305	26.641	−122.471	−38.401	1.00	55.05	N
ATOM	7297	CA	TRP	B	305	26.424	−123.837	−38.796	1.00	55.44	C
ATOM	7298	CB	TRP	B	305	25.705	−123.852	−40.126	1.00	52.55	C
ATOM	7299	CG	TRP	B	305	24.348	−123.235	−40.088	1.00	56.07	C
ATOM	7300	CD1	TRP	B	305	24.047	−121.922	−40.265	1.00	55.38	C
ATOM	7301	NE1	TRP	B	305	22.688	−121.737	−40.175	1.00	53.41	N
ATOM	7302	CE2	TRP	B	305	22.084	−122.941	−39.941	1.00	51.41	C
ATOM	7303	CD2	TRP	B	305	23.097	−123.912	−39.883	1.00	53.19	C
ATOM	7304	CE3	TRP	B	305	22.740	−125.246	−39.643	1.00	55.46	C
ATOM	7305	CZ3	TRP	B	305	21.377	−125.364	−39.480	1.00	53.71	C
ATOM	7306	CH2	TRP	B	305	20.396	−124.372	−39.554	1.00	54.60	C
ATOM	7307	CZ2	TRP	B	305	20.729	−123.256	−39.780	1.00	56.40	C
ATOM	7308	C	TRP	B	305	27.778	−124.329	−38.922	1.00	62.46	C
ATOM	7309	O	TRP	B	305	28.699	−124.002	−39.559	1.00	59.00	O
ATOM	7310	N	SER	B	306	27.913	−125.695	−38.296	1.00	70.55	N
ATOM	7311	CA	SER	B	306	29.089	−126.340	−38.529	1.00	80.17	C
ATOM	7312	CB	SER	B	306	28.932	−127.896	−37.833	1.00	84.07	C
ATOM	7313	OG	SER	B	306	29.965	−128.793	−38.214	1.00	93.77	O
ATOM	7314	C	SER	B	306	29.318	−126.142	−40.035	1.00	76.72	C
ATOM	7315	O	SER	B	306	28.363	−127.040	−40.774	1.00	74.14	O
ATOM	7316	N	PRO	B	307	30.574	−126.548	−40.499	1.00	74.43	N
ATOM	7317	CA	PRO	B	307	30.877	−126.907	−41.890	1.00	71.27	C
ATOM	7318	CB	PRO	B	307	32.225	−126.228	−42.156	1.00	71.07	C
ATOM	7319	CG	PRO	B	307	32.842	−126.011	−40.814	1.00	70.99	C
ATOM	7320	CD	PRO	B	307	31.763	−126.069	−39.766	1.00	70.62	C
ATOM	7321	C	PRO	B	307	30.975	−128.430	−42.030	1.00	67.09	C
ATOM	7322	O	PRO	B	307	30.561	−128.575	−43.042	1.00	66.26	O
ATOM	7323	N	LEU	B	308	31.475	−129.086	−40.984	1.00	64.53	N
ATOM	7324	CA	LEU	B	308	31.704	−130.526	−40.940	1.00	65.78	C
ATOM	7325	CB	LEU	B	308	32.624	−130.865	−39.757	1.00	59.97	C
ATOM	7326	CG	LEU	B	308	34.148	−130.617	−39.821	1.00	57.56	C
ATOM	7327	CD1	LEU	B	308	34.592	−129.470	−40.725	1.00	54.63	C
ATOM	7328	CD2	LEU	B	308	34.727	−130.450	−38.420	1.00	53.52	C
ATOM	7329	C	LEU	B	308	30.409	−131.335	−40.844	1.00	70.02	C
ATOM	7330	O	LEU	B	308	30.240	−132.322	−41.559	1.00	75.78	O
ATOM	7331	N	ASN	B	309	29.505	−130.929	−39.953	1.00	70.96	N
ATOM	7332	CA	ASN	B	309	28.205	−131.573	−39.832	1.00	71.52	C
ATOM	7333	CB	ASN	B	309	28.071	−132.255	−38.465	1.00	71.77	C
ATOM	7334	CG	ASN	B	309	26.837	−133.145	−38.366	1.00	74.09	C
ATOM	7335	OD1	ASN	B	309	25.860	−132.982	−39.108	1.00	71.34	O
ATOM	7336	ND2	ASN	B	309	26.877	−134.094	−37.438	1.00	74.86	N
ATOM	7337	C	ASN	B	309	27.064	−130.574	−40.088	1.00	75.27	C
ATOM	7338	O	ASN	B	309	26.655	−129.815	−39.204	1.00	75.33	O
ATOM	7339	N	HIS	B	310	26.549	−130.591	−41.309	1.00	76.43	N
ATOM	7340	CA	HIS	B	310	25.577	−129.594	−41.763	1.00	79.78	C
ATOM	7341	CB	HIS	B	310	25.359	−129.724	−43.281	1.00	83.64	C
ATOM	7342	CG	HIS	B	310	26.454	−129.113	−44.104	1.00	86.38	C
ATOM	7343	ND1	HIS	B	310	26.282	−178.755	−45.425	1.00	89.10	N
ATOM	7344	CE1	HIS	B	310	27.407	−128.237	−45.889	1.00	88.78	C
ATOM	7345	NE2	HIS	B	310	28.298	−128.234	−44.914	1.00	86.75	N
ATOM	7346	CD2	HIS	B	310	27.727	−128.776	−43.787	1.00	85.51	C
ATOM	7347	C	HIS	B	310	24.233	−129.557	−41.018	1.00	76.78	C
ATOM	7348	O	HIS	B	310	23.388	−128.720	−41.318	1.00	79.52	O
ATOM	7349	N	SER	B	311	24.025	−130.446	−40.054	1.00	76.12	N
ATOM	7350	CA	SER	B	311	22.791	−130.401	−39.264	1.00	74.23	C
ATOM	7351	CB	SER	B	311	22.126	−131.772	−39.209	1.00	76.02	C
ATOM	7352	OG	SER	B	311	21.324	−131.975	−40.360	1.00	79.56	O
ATOM	7353	C	SER	B	311	23.040	−129.840	−37.863	1.00	74.76	C
ATOM	7354	O	SER	B	311	22.098	−129.611	−37.087	1.00	65.64	O
ATOM	7355	N	LEU	B	312	24.321	−129.593	−37.581	1.00	71.87	N
ATOM	7356	CA	LEU	B	312	24.787	−129.093	−36.298	1.00	73.07	C
ATOM	7357	CB	LEU	B	312	26.154	−129.699	−35.977	1.00	74.80	C
ATOM	7358	CG	LEU	B	312	26.488	−130.023	−34.520	1.00	83.60	C
ATOM	7359	CD1	LEU	B	312	27.276	−131.330	−34.452	1.00	87.20	C
ATOM	7360	CD2	LEU	B	312	27.223	−128.879	−33.821	1.00	82.53	C
ATOM	7361	C	LEU	B	312	24.883	−127.573	−36.342	1.00	71.84	C
ATOM	7362	O	LEU	B	312	25.450	−127.011	−37.257	1.00	73.02	U
ATOM	7363	N	LEU	B	313	24.332	−126.920	−35.317	1.00	69.74	N
ATOM	7364	CA	LEU	B	313	24.266	−125.445	−35.243	1.00	64.39	C
ATOM	7365	CB	LEU	B	313	22.854	−124.963	−35.569	1.00	61.46	C
ATOM	7366	CG	LEU	B	313	22.557	−123.479	−35.376	1.00	55.13	C
ATOM	7367	CD1	LEU	B	313	23.313	−122.671	−36.421	1.00	51.86	C
ATOM	7368	CD2	LEU	B	313	21.054	−123.250	−35.479	1.00	54.09	C
ATOM	7369	C	LEU	B	313	24.661	−124.899	−33.878	1.00	53.33	C
ATOM	7370	O	LEU	B	313	24.164	−125.350	−32.850	1.00	59.72	O
ATOM	7371	N	THR	B	314	25.536	−123.906	−33.868	1.00	55.10	N
ATOM	7372	CA	THR	B	314	26.020	−123.378	−32.605	1.00	57.53	C
ATOM	7373	CB	THR	B	314	27.548	−123.518	−32.479	1.00	54.42	C
ATOM	7374	OG1	THR	B	314	27.882	−124.896	−32.664	1.00	63.71	O
ATOM	7375	CG2	THR	B	314	28.016	−123.091	−31.087	1.00	54.24	C
ATOM	7376	C	THR	B	314	25.556	−121.954	−32.339	1.00	57.26	C
ATOM	7377	O	THR	B	314	25.742	−121.067	−33.181	1.00	64.90	O
ATOM	7378	N	THR	B	315	24.941	−121.757	−31.169	1.00	51.87	N
ATOM	7379	CA	THR	B	315	24.535	−120.421	−30.703	1.00	47.30	C
ATOM	7380	CG	THR	B	315	23.024	−120.331	−30.419	1.00	45.79	C
ATOM	7381	OG1	THR	B	315	22.644	−121.342	−29.474	1.00	43.60	O
ATOM	7382	CG2	THR	B	315	22.217	−120.477	−31.705	1.00	43.54	C
ATOM	7383	C	THR	B	315	25.246	−120.038	−29.432	1.00	45.57	C
ATOM	7384	O	THR	B	315	25.549	−120.883	−28.602	1.00	41.48	O
ATOM	7385	N	VAL	B	316	25.521	−118.753	−29.281	1.00	41.31	N
ATOM	7386	CA	VAL	B	316	26.041	−118.243	−28.017	1.00	50.47	C
ATOM	7387	CB	VAL	B	316	27.525	−117.819	−28.144	1.00	41.18	C
ATOM	7388	CG1	VAL	B	316	28.335	−118.974	−28.714	1.00	46.57	C
ATOM	7389	CG2	VAL	B	316	27.673	−116.585	−29.018	1.00	46.22	C
ATOM	7390	C	VAL	B	316	25.154	−117.111	−27.471	1.00	52.60	C
ATOM	7391	O	VAL	B	316	24.422	−166.467	−28.226	1.00	52.74	O
ATOM	7392	N	GLY	B	317	25.227	−116.877	−26.161	1.00	55.68	N
ATOM	7393	CA	GLY	B	317	24.378	−115.197	−25.490	1.00	55.21	C
ATOM	7394	C	GLY	B	317	25.087	−115.068	−24.441	1.00	58.20	C
ATOM	7395	O	GLY	B	317	26.287	−115.212	−24.224	1.00	58.56	O
ATOM	7396	N	TRP	B	318	24.342	−114.177	−23.795	1.00	59.38	N
ATOM	7397	CA	TRP	B	318	24.880	−113.403	−22.676	1.00	51.70	C
ATOM	7398	CB	TRP	B	318	24.179	−112.052	−22.564	1.00	54.29	C
ATOM	7399	CG	TRP	B	318	24.625	−111.036	−23.588	1.00	54.39	C
ATOM	7400	CD1	TRP	B	318	25.611	−111.184	−24.512	1.00	52.29	C
ATOM	7401	NE1	TRP	B	318	25.742	−110.042	−25.260	1.00	50.57	N
ATOM	7402	CE2	TRP	B	318	24.849	−109.109	−24.807	1.00	52.76	C
ATOM	7403	CD2	TRP	B	318	24.120	−109.702	−23.753	1.00	56.72	C
ATOM	7404	CE3	TRP	B	318	23.123	−108.954	−23.116	1.00	53.70	C
ATOM	7405	CZ3	TRP	B	318	22.894	−107.660	−23.551	1.00	55.24	C
ATOM	7406	CH2	TRP	B	318	23.631	−107.102	−24.607	1.00	50.74	C
ATOM	7407	CZ2	TRP	B	318	24.610	−107.106	−25.243	1.00	47.83	C
ATOM	7408	C	TRP	B	318	24.794	−114.168	−21.365	1.00	47.18	C
ATOM	7409	O	TRP	B	318	25.199	−113.670	−20.329	1.00	47.16	O
ATOM	7410	N	ASP	B	319	24.261	−115.383	−21.430	1.00	49.02	N
ATOM	7411	CA	ASP	B	319	24.266	−116.327	−20.316	1.00	57.55	C
ATOM	7412	CB	ASP	B	319	23.074	−117.183	−20.422	1.00	46.87	C
ATOM	7413	CG	ASP	B	319	22.991	−117.985	−21.771	1.00	46.54	C
ATOM	7414	OD1	ASP	B	319	23.904	−117.810	−22.627	1.00	41.95	O
ATOM	7415	OD2	ASP	B	319	21.985	−118.707	−21.977	1.00	45.97	O
ATOM	7416	C	ASP	B	319	25.564	−117.142	−20.265	1.00	54.29	C
ATOM	7417	O	ASP	B	319	25.729	−118.004	−19.403	1.00	58.33	O
ATOM	7418	N	HIS	B	320	26.474	−116.872	−21.197	1.00	53.30	N
ATOM	7419	CA	HIS	B	320	27.747	−117.578	−21.277	1.00	53.88	C
ATOM	7420	CB	HIS	B	320	28.484	−117.469	−19.948	1.00	55.71	C
ATOM	7421	CG	HIS	B	320	29.970	−117.161	−20.081	1.00	59.17	C
ATOM	7422	ND1	HIS	B	320	30.655	−116.226	−20.678	1.00	57.34	N
ATOM	7423	CE1	HIS	B	320	31.950	−116.682	−20.638	1.00	56.72	C
ATOM	7424	NE2	HIS	B	320	32.128	−117.846	−20.038	1.00	57.96	N
ATOM	7425	CD2	HIS	B	320	30.905	−118.356	−19.680	1.00	52.77	C
ATOM	7426	C	HIS	B	320	27.601	−119.048	−21.709	1.00	52.76	C
ATOM	7427	C	HIS	B	320	28.526	−119.840	−21.572	1.00	54.40	O
ATOM	7428	N	GLN	B	321	26.438	−119.409	−22.232	1.00	52.98	N
ATOM	7429	CA	GLN	B	321	26.272	−120.702	−22.869	1.00	53.31	C
ATOM	7430	CB	GLN	B	321	24.830	−121.182	−22.772	1.00	56.99	C
ATOM	7431	CG	GLN	B	321	24.471	−121.760	−21.416	1.00	63.11	C
ATOM	7432	CD	GLN	B	321	23.113	−122.441	−21.415	1.00	68.08	C
ATOM	7433	OE1	GLN	B	321	23.024	−123.671	−23.331	1.00	70.50	O
ATOM	7434	NE2	GLN	B	321	22.042	−121.645	−21.525	1.00	67.55	N
ATOM	7435	C	GLN	B	321	26.740	−120.712	−24.329	1.00	54.33	C
ATOM	7436	C	GLN	B	321	26.479	−119.769	−25.092	1.00	49.82	O
ATOM	7437	N	VAL	B	322	27.468	−121.780	−24.682	1.00	55.30	N
ATOM	7438	CA	VAL	B	322	27.786	−122.137	−26.064	1.00	48.79	C
ATOM	7439	CB	VAL	B	332	29.289	−122.460	−26.233	1.00	45.29	C
ATOM	7440	CG1	VAL	B	322	29.570	−123.011	−27.624	1.00	43.32	C
ATOM	7441	CG2	VAL	B	322	30.144	−121.225	−25.995	1.00	43.27	C
ATOM	7442	C	VAL	B	322	26.966	−123.391	−26.332	1.00	50.58	C
ATOM	7443	O	VAL	B	322	27.308	−124.447	−25.821	1.00	50.24	O
ATOM	7444	N	VAL	B	323	25.866	−123.272	−27.079	1.00	54.00	N
ATOM	7445	CA	VAL	B	323	24.966	−124.415	−27.300	1.00	55.64	C
ATOM	7446	CB	VAL	B	323	23.493	−124.076	−27.006	1.00	56.96	C
ATOM	7447	CG1	VAL	B	323	22.593	−125.289	−27.222	1.00	52.42	C
ATOM	7443	CG2	VAL	B	323	23.342	−123.584	−25.581	1.00	58.83	C
ATOM	7449	C	VAL	B	323	25.085	−124.953	−28.716	1.00	58.43	C
ATOM	7459	O	VAL	B	323	25.115	−124.187	−29.679	1.00	61.02	O
ATOM	7452	N	HIS	B	324	25.155	−126.280	−28.819	1.00	62.49	N
ATOM	7452	CA	HIS	B	324	25.232	−126.989	−30.093	1.00	59.90	C
ATOM	7453	CB	HIS	B	324	26.351	−128.024	−30.066	1.00	57.28	C
ATOM	7454	CG	HIS	B	324	27.671	−127.463	−29.652	1.00	58.55	C
ATOM	7455	ND1	HIS	B	324	28.393	−126.598	−30.450	1.00	56.29	N
ATOM	7456	CE1	HIS	B	324	29.518	−126.273	−29.832	1.00	58.20	C
ATOM	7457	NE2	HIS	B	324	29.547	−126.889	−28.661	1.00	60.23	N
ATOM	7458	CD2	HIS	B	324	28.401	−127.638	−28.523	1.00	59.59	C
ATOM	7459	C	HIS	B	324	23.907	−127.676	−30.370	1.00	58.90	C
ATOM	7460	O	HIS	B	324	23.547	−128.591	−29.594	1.00	58.23	O
ATOM	7461	N	HIS	B	325	23.177	−127.197	−31.318	1.00	62.99	N
ATOM	7462	CA	HIS	B	325	21.846	−127.692	−31.632	1.00	66.47	C
ATOM	7463	CB	HTS	B	325	20.904	−126.530	−32.033	1.00	69.59	C
ATOM	7464	CG	HIS	B	325	20.877	−125.377	−31.068	1.00	69.21	C
ATOM	7465	ND1	HIS	B	325	19.865	−125.198	−30.146	1.00	68.23	N
ATOM	7466	CE1	HIS	B	325	20.103	−124.108	−29.439	1.00	63.34	C
ATOM	7467	NE2	HIS	B	325	21.222	−123.562	−29.880	1.00	65.95	N
ATOM	7468	CO2	HIS	B	325	21.725	−124.334	−30.900	1.00	66.11	C
ATOM	7469	C	HIS	B	325	21.918	−128.688	−32.792	1.00	67.53	C
ATOM	7470	O	HIS	B	325	22.685	−128.499	−33.748	1.00	63.87	O
ATOM	7471	N	VAL	B	326	21.094	−129.728	−32.715	1.00	66.86	N
ATOM	7472	CA	VAL	B	326	20.930	−130.664	−33.822	1.00	67.27	C
ATOM	7473	CB	VAL	B	326	20.944	−132.137	−33.347	1.00	69.38	C
ATOM	7474	CG1	VAL	B	326	22.348	−132.529	−32.905	1.00	59.96	C
ATOM	7475	CG2	VAL	B	326	19.937	−132.362	−32.219	1.00	71.13	C
ATOM	7476	C	VAL	B	326	19.641	−130.344	−34.554	1.00	65.52	C
ATOM	7477	O	VAL	B	326	18.557	−130.432	−33.983	1.00	72.01	O
ATOM	7478	N	VAL	B	327	19.762	−129.971	−35.820	1.00	70.08	N
ATOM	7479	CA	VAL	B	327	18.615	−129.459	−36.568	1.00	75.93	C
ATOM	7480	CB	VAL	B	327	18.929	−128.097	−37.238	1.00	73.56	C
ATOM	7481	CG1	VAL	B	327	17.692	−127.523	−37.916	1.00	72.87	C
ATOM	7482	CG2	VAL	B	327	19.450	−127.109	−36.208	1.00	73.84	C
ATOM	7483	C	VAL	B	327	18.080	−130.457	−37.600	1.00	81.04	C
ATOM	7484	O	VAL	B	327	18.810	−130.871	−38.508	1.00	82.14	O
ATOM	7485	N	PRO	B	328	16.795	−130.838	−37.459	1.00	85.06	N
ATOM	7486	CA	PRO	B	328	16.068	−131.675	−38.422	1.00	88.07	C
ATOM	7487	CB	PRO	B	328	14.720	−131.911	−37.731	1.00	88.26	C
ATOM	7488	CO	PRO	B	326	14.584	−130.780	−56.754	1.00	87.00	C
ATOM	7489	CD	PRO	B	328	15.978	−130.543	−36.267	1.00	83.99	C
ATOM	7490	C	PRO	B	328	15.850	−130.982	−39.769	1.00	90.33	C
ATOM	7491	O	PRO	B	328	16.771	−130.909	−40.587	1.00	91.20	O
HETATM	7492	OXT	SAM	C	1	24.948	−38.342	−8.475	1.00	39.37	O
HETATM	7493	C	SAM	C	1	24.982	−38.422	−7.205	1.00	44.52	C
HETATM	7494	O	SAM	C	1	25.802	−39.093	−6.528	1.00	42.87	O
HETATM	7495	CA	SAM	C	1	23.943	−37.679	−6.405	1.00	46.43	C
HETATM	7496	N	SAM	C	1	23.478	−36.542	−7.192	1.00	42.46	N
HETATM	7497	CB	SAM	C	1	22.812	−38.627	−5.940	1.00	45.76	C
HETATM	7498	CG	SAM	C	1	21.983	−39.275	−7.063	1.00	45.03	C
HETATM	7499	SD	SAM	C	1	20.677	−40.147	−6.469	1.00	51.91	S
HETATM	7500	CE	SAM	C	1	20.218	−41.305	−7.574	1.00	48.79	C
HETATM	7501	C5′	SAM	C	1	19.350	−39.169	−6.224	1.00	43.20	C
HETATM	7502	C4′	SAM	C	1	19.393	−38.439	−4.876	1.00	38.13	C
HETATM	7503	C3′	SAM	C	1	19.245	−39.380	−3.688	1.00	37.58	C
HETATM	7504	O3′	SAM	C	1	20.289	−39.130	−2.729	1.00	34.68	O
HETATM	7505	O2′	SAM	C	1	17.846	−39.057	−3.160	1.00	33.74	C
HETATM	7506	O2′	SAM	C	1	17.721	−39.226	−1.761	1.00	34.10	O
HETATM	7507	C2′	SAM	c	1	17.640	−37.610	−3.524	1.00	34.87	C
HETATM	7508	O4′	SAM	C	1	18.263	−37.557	−4.818	1.00	37.13	O
HETATM	7509	N9	SAM	C	1	16.224	−37.195	−3.708	1.00	34.32	N
HETATM	7510	C4	SAM	C	1	15.631	−36.076	−3.272	1.00	32.31	C
HETATM	7511	C5	SAM	C	1	14.244	−36.136	−3.759	1.00	31.95	C
HETATM	7512	N7	SAM	C	1	14.129	−37.256	−4.463	1.00	34.39	N
HETATM	7513	C8	SAM	C	1	15.329	−37.888	−4.427	1.00	33.49	C
HETATM	7514	N3	SAM	C	1	15.995	−35.013	−2.513	1.00	32.65	N
HETATM	7515	C2	SAM	C	1	15.100	−34.043	−2.242	1.00	33.83	C
HETATM	7516	N1	SAM	C	1	13.805	−34.054	−2.665	1.00	34.68	N
HETATM	7517	C6	SAM	C	1	13.326	−35.052	−3.432	1.00	32.95	C
HETATM	7518	N6	SAM	C	1	12.046	−35.076	−3.885	1.00	33.43	N
HETATM	7519	CAU	EPZ	D	1	22.723	−44.752	−1.0.742	1.00	51.57	C
HETATM	7520	CAV	EPZ	D	1	23.120	−43.372	−10.237	1.00	47.74	C
HETATM	7521	CAW	EPZ	D	1	23.070	−43.337	−8.834	1.00	51.47	C
HETATM	7522	CBC	EPZ	D	1	23.798	−42.341	−8.164	1.00	48.55	C
HETATM	7523	CBB	EPZ	D	1	23.771	−42.282	−6.772	1.00	45.51	C
HETATM	7524	CBA	EPZ	D	1	23.013	−43.198	−6.040	1.00	44.72	C
HETATM	7525	CAZ	EPZ	D	1	22.286	−44.197	−6.686	1.00	46.57	C
HETATM	7526	CAX	EPZ	D	1	22.310	−44.273	−8.084	1.00	49.86	C
HETATM	7527	CAY	EPZ	D	1	21.563	−45.292	−8.682	1.00	49.39	C
HETATM	7528	NAT	EPZ	D	1	21.462	−45.233	−10.152	1.00	51.01	N
HETATM	7529	CAS	EPZ	D	1	21.177	−46.598	−10.669	1.00	51.46	C
HETATM	7530	CAB	EPZ	D	1	19.672	−46.866	−11.023	1.00	51.32	C
HETATM	7531	OAA	EPZ	D	1	18.864	−46.029	−10.207	1.00	48.37	O
HETATM	7532	CAC	EPZ	D	1	19.246	−48.360	−10.868	1.00	49.56	C
HETATM	7533	NAD	EPZ	D	1	20.418	−49.234	−10.581	1.00	51.11	N
HETATM	7534	CAE	EPZ	D	1	21.291	−49.700	−11.543	1.00	54.66	C
HETATM	7535	OAF	EPZ	D	1	21.202	−49.498	−12.761	1.00	50.34	O
HETATM	7536	CAG	EPZ	D	1	22.466	−50.553	−11.034	1.00	57.14	C
HETATM	7537	OAH	EPZ	D	1	22.131	−51.205	−9.794	1.00	60.66	O
HETATM	7538	CAI	EPZ	D	1	23.253	−51.465	−9.196	1.00	60.22	C
HETATM	7539	CAJ	EPZ	D	1	23.353	−51.460	−7.813	1.00	66.20	C
HETATM	7540	NAK	EPZ	D	1	22.376	−50.825	−7.122	1.00	69.49	N
HETATM	7541	CAL	EPZ	D	1	22.502	−50.613	−5.723	1.00	69.86	C
HETATM	7542	CAM	EPZ	D	1	23.640	−51.062	−5.043	1.00	67.83	C
HETATM	7543	CAN	EPZ	D	1	24.643	−51.719	−5.760	1.00	64.77	C
HETATM	7544	CAO	EPZ	D	1	24.499	−51.917	−7.140	1.00	65.97	C
HETATM	7545	CAP	EPZ	D	1	25.499	−52.170	−7.868	1.00	63.10	C
HETATM	7346	CAQ	EPZ	D	1	25.380	−52.771	−9.247	1.00	61.31	C
HETATM	7547	CAR	EPZ	D	1	24.252	−52.117	−9.922	1.00	59.51	C
HETATM	7548	O3	GOL	G	1	32.520	−80.088	−12.097	1.00	57.51	O
HETATM	7549	C3	GOL	G	1	31.357	−79.109	−12.683	1.00	55.19	C
HETATM	7550	C2	GOL	G	1	31.384	−79.902	−14.145	1.00	53.68	C
HETATM	7551	O2	GOL	G	1	32.190	−78.909	−14.797	1.00	51.85	O
HETATM	7552	C1	GOL	G	1	29.941	−79.997	−14.641	1.00	49.19	C
HETATM	7553	O1	GOL	G	1	29.576	−78.199	−15.490	1.00	47.87	O
HETATM	7554	O3	GOL	G	2	10.722	−100.090	−41.603	1.00	61.14	O
HETATM	7555	C3	GOL	G	2	10.929	−99.704	−42.964	1.00	60.66	C
HETATM	7556	C2	GOL	G	2	11.663	−100.167	−43.596	1.00	65.75	C
HETATM	7557	O2	GOL	G	2	13.077	−100.124	−43.519	1.00	60.59	O
HETATM	7558	C1	GOL	G	2	11.155	−101.004	−45.029	1.00	66.71	C
HETATM	7559	O1	GOL	G	2	10.019	−101.183	−45.004	1.00	67.89	O
HETATM	7560	O	HOH	H	1	16.784	−35.117	−12.821	1.00	26.60	O
HETATM	7561	O	HOH	H	2	17.742	−41.335	−0.744	1.00	42.67	O
HETATM	7562	O	HOH	H	3	19.835	−110.178	−28.740	1.00	45.13	O
HETATM	7563	O	HOH	H	4	20.841	−88.387	−51.360	1.00	38.20	O
HETATM	7564	O	HOH	H	5	17.359	−30.527	−12.966	1.00	38.96	O
HETATM	7565	O	HOH	H	6	22.920	−99.424	−21.217	1.00	30.84	O
HETATM	7565	O	HOH	H	7	35.615	−99.243	−13.970	1.00	43.23	O
HETATM	7567	O	HOH	H	8	22.190	−57.389	−12.757	1.00	40.88	O
HETATM	7568	O	HOH	H	9	9.057	−29.800	−14.394	1.00	39.76	O
HETATM	7569	O	HOH	H	10	23.038	−67.841	−28.330	1.00	52.70	O
HETATM	7570	O	HOH	H	11	30.503	−46.141	3.138	1.00	35.20	O
HETATM	7571	O	HOH	H	12	9.315	−26.602	−3.239	1.00	41.70	O
HETATM	7572	O	HOH	H	13	14.250	−98.754	−46.179	1.00	45.35	O
HETATM	7573	O	HOH	H	14	29.724	−108.034	−26.437	1.00	50.04	O
HETATM	7574	O	HOH	H	15	14.682	−71.012	−20.059	1.00	42.57	O
HETATM	7575	O	HOH	H	16	38.706	−103.571	−28.691	1.00	43.52	O
HETATM	7576	O	HOH	H	17	11.001	−40.391	−19.729	1.00	33.38	O
HETATM	7577	O	HOH	H	18	7.321	−94.376	−17.224	1.00	27.67	O
HETATM	7578	O	HOH	H	19	−1.952	−43.345	−17.517	1.00	34.75	O
HETATM	7579	O	HOH	H	20	4.556	−34.455	−18.713	1.00	28.46	O
HETATM	7580	O	HOH	H	21	4.088	−96.955	−23.287	1.00	37.22	O
HETATM	7581	O	HOH	H	22	12.208	−51.818	−33.880	1.00	30.39	O
HETATM	7582	O	HOH	H	23	20.838	−59.597	−28.999	1.00	57.47	O
HETATM	7583	O	HOH	H	24	28.635	−107.628	−61.389	1.00	40.13	O
HETATM	7584	O	HOH	H	25	9.589	−19.417	−5.262	1.00	42.70	O
HETATM	7585	O	HOH	H	26	15.846	−47.832	−12.560	1.00	24.84	O
HETATM	7586	O	HOH	H	27	27.592	−110.742	−33.963	1.00	36.13	O
HETATM	7587	O	HOH	H	28	4.885	−63.876	−5.960	1.00	33.45	O
HETATM	7588	O	HOH	H	29	21.316	−85.204	−30.587	1.00	38.59	O
HETATM	7589	O	HOH	H	30	25.374	−88.050	−25.419	1.00	35.49	O
HETATM	7590	O	HOH	H	31	23.174	−112.378	−38.179	1.00	44.90	O
HETATM	7591	O	HOH	H	32	5.153	−76.303	−31.579	1.00	53.23	O
HETATM	7592	O	HOH	H	33	11.330	−57.144	−41.083	1.00	42.53	O
HETATM	7593	O	HOH	H	34	5.091	−33.055	−8.040	1.00	38.65	O
HETATM	7594	O	HOH	H	35	25.114	−25.647	5.246	1.00	42.49	O
HETATM	7595	O	HOH	H	36	1.961	−59.487	−36.635	1.00	50.24	O
HETATM	7596	O	HOH	H	37	28.600	−109.453	−15.663	1.00	41.41	O
HETATM	7597	O	HOH	H	38	−3.523	−64.888	−26.622	1.00	37.50	O
HETATM	7598	O	HOH	H	39	4.909	−35.169	−5.292	1.00	36.18	O
HETATM	7599	O	HOH	H	40	14.763	−118.954	−23.750	1.00	45.48	O
HETATM	7600	O	HOH	H	41	6.485	−25.953	−8.693	1.00	58.07	O
HETATM	7601	O	HOH	H	42	35.439	−87.406	−1717	1.00	45.31	O
HETATM	7602	O	HOH	H	43	19.479	−92.750	−29.067	1.00	38.38	O
HETATM	7603	O	HOH	H	44	2.421	−38.513	−11.813	1.00	32.86	O
HETATM	7604	O	HOH	H	45	23.552	−116.318	−43.576	1.00	38.63	O
HETATM	7605	O	HOH	H	46	14.791	−75.614	−18.928	1.00	29.07	O
HETATM	7606	O	HOH	H	47	−5.233	−52.672	−32.401	1.00	46.54	O
HETATM	7607	O	HOH	H	48	11.360	−48.635	−11.063	1.00	33.06	O
HETATM	7608	O	HOH	H	49	26.386	−77.555	−37.301	1.00	49.02	O
HETATM	7609	O	HOH	H	50	33.895	−68.746	−21.311	1.00	51.92	O
HETATM	7610	O	HOH	H	51	1.042	−43.844	−29.304	1.00	40.59	O
HETATM	7611	O	HOH	H	52	22.933	−87.329	−29.611	1.00	37.07	O
HETATM	7612	O	HOH	H	53	1.554	−63.358	−22.604	1.00	31.97	O
HETATM	7613	O	HOH	H	54	−2.274	−53.872	−31.685	1.00	41.87	O
HETATM	7614	O	HOH	H	55	21.090	−107.487	10.151	1.00	49.14	O
HETATM	7615	O	HOH	H	56	10.423	−20.793	−2.866	1.00	51.05	O
HETATM	7616	O	HOH	H	57	23.046	−96.301	−56.301	1.00	44.40	O
HETATM	7617	O	HOH	H	58	15.964	−132.318	−42.684	1.00	54.88	O
HETATM	7618	O	HOH	H	59	26.453	−48.445	3.602	1.00	42.29	O
HETATM	7619	O	HOH	H	60	12.631	−89.449	−27.316	1.00	30.73	O
HETATM	7620	O	HOH	H	61	9.556	−59.929	−7.632	1.00	30.93	O
HETATM	7621	O	HOH	H	62	22.130	−91.640	−29.076	1.00	33.54	O
HETATM	7622	O	HOH	H	63	49.483	−98.998	−41.413	1.00	45.72	O
HETATM	7623	O	HOH	H	64	33.835	−29.850	−18.339	1.00	41.41	O
HETATM	7624	O	HOH	H	65	17.499	−57.505	−33.304	1.00	41.36	O
HETATM	7625	O	HOH	H	66	13.740	−98.446	−13.308	1.00	31.94	O
HETATM	7626	O	HOH	H	67	35.697	−25.622	−22.751	1.00	55.14	O
HETATM	7627	O	HOH	H	68	34.404	−108.405	−56.891	1.00	47.35	O
HETATM	7628	O	HOH	H	69	14.385	−110.451	−23.241	1.00	50.36	O
HETATM	7629	O	HOH	H	70	23.613	−33.720	9.520	1.00	31.17	O
HETATM	7630	O	HOH	H	71	2.381	−32.464	−18.615	1.00	41.66	O
HETATM	7631	O	HOH	H	72	16.444	−91.141	−33.984	1.00	44.72	O
HETATM	7632	O	HOH	H	73	5.308	−71.399	−18.877	1.00	41.24	O
HETATM	7633	O	HOH	H	74	37.136	−36.893	−16.136	1.00	48.27	O
HETATM	7634	O	HOH	H	75	34.933	−79.260	−13.581	1.00	51.16	O
HETATM	7635	O	HOH	H	76	21.596	−99.878	−33.901	1.00	42.32	O
HETATM	7636	O	HOH	H	77	22.905	−99.744	−27.618	1.00	39.33	O
HETATM	7637	O	HOH	H	78	18.054	−63.108	−9.932	1.00	31.55	O
HETATM	7638	O	HOH	H	79	14.309	−14.662	−6.035	1.00	41.32	O
HETATM	7639	O	HOH	H	80	−0.650	−58.855	−7.740	1.00	50.06	O
HETATM	7640	O	HOH	H	81	0.661	−35.747	−13.486	1.00	45.90	O
HETATM	7641	O	HOH	H	82	33.705	−90.174	−39.223	1.00	51.55	O
HETATM	7642	O	HOH	H	83	32.989	−42.748	−4.139	1.00	41.04	O
HETATM	7643	O	HOH	H	84	38.509	−30.360	−13.877	1.00	53.19	O
HETATM	7644	O	HOH	H	85	27.533	−35.918	−24.997	1.00	46.70	O
HETATM	7645	O	HOH	H	86	19.478	−83.192	−46.474	1.00	43.36	O
HETATM	7646	O	HOH	H	87	18.956	−28.066	6.537	1.00	44.86	O
HETATM	7647	O	HOH	H	88	−0.796	−60.903	−10.870	1.00	45.87	O
HETATM	7648	O	HOH	H	89	12.439	−74.919	−17.717	1.00	44.20	O
HETATM	7649	O	HOH	H	90	−0.744	−64.293	−24.005	1.00	35.33	O
HETATM	7650	O	HOH	H	91	7.517	−32.918	−20.098	1.00	51.47	O
HETATM	7651	O	HOH	H	92	34.425	−72.078	−19.482	1.00	54.74	O
HETATM	7652	O	HOH	H	93	24.287	−111.169	−42.555	1.00	47.09	O
HETATM	7653	O	HOH	H	94	35.128	−93.423	−29.689	1.00	49.69	O
HETATM	7654	O	HOH	H	95	8.511	−39.094	0.456	1.00	52.43	O
HETATM	7655	O	HOH	H	96	13.023	−40.153	−12.645	1.00	35.95	O
HETATM	7656	O	HOH	H	97	17.195	−37.187	−26.224	1.00	44.65	O
HETATM	7657	O	HOH	H	98	15.566	−36.949	−24.395	1.00	46.58	O
HETATM	7658	O	HOH	H	99	6.008	−23.250	−17.067	1.00	60.71	O
HETATM	7659	O	HOH	H	100	9.617	−22.302	−14.916	1.00	46.84	O
HETATM	7660	O	HOH	H	101	9.604	−44.019	−3.621	1.00	46.74	O
HETATM	7661	O	HOH	H	102	31.850	−37.085	−2.986	1.00	55.67	O
HETATM	7662	O	HOH	H	103	19.758	−42.172	−10.196	1.00	34.59	O
HETATM	7663	O	HOH	H	104	25.613	−34.121	−5.639	1.00	41.13	O
HETATM	7664	O	HOH	H	105	−5.247	−55.508	−32.092	1.00	48.59	O
HETATM	7665	O	HOH	H	106	−8.037	−54.584	−28.473	1.00	32.83	Q
HETATM	7666	O	HOH	H	107	29.553	−51.002	−23.149	1.00	50.36	O
HETATM	7667	O	HOH	H	108	31.118	−49.039	−22.091	1.00	45.35	O
HETATM	7668	O	HOH	H	109	17.434	−67.233	−28.122	1.00	49.87	O
HETATM	7669	O	HOH	H	110	18.723	−104.005	−14.762	1.00	40.39	O
HETATM	7670	O	HOH	H	111	16.565	−105.73	−14.308	1.00	35.54	O
HETATM	7671	O	HOH	H	112	32.557	−93.154	−2.645	1.00	45.48	O
HETATM	7672	O	HOH	H	113	26.529	−89.517	−30.451	1.00	45.86	O
HETATM	7673	O	HOH	H	114	40.988	−90.58	−25.626	1.00	43.01	O
HETATM	7674	O	HOH	H	115	47.213	−71.57	−32.777	1.00	52.96	O
HETATM	7675	O	HOH	H	116	16.440	−71.676	−17.684	1.00	36.80	O
HETATM	7676	O	HOH	H	117	−1.199	−45.264	−27.906	1.00	54.47	O
HETATM	7677	O	HOH	H	118	14.933	−60.093	−7.186	1.00	45.47	O
HETATM	7678	O	HOH	H	119	15.927	−26.388	−18.997	1.00	37.82	O
HETATM	7679	O	HOH	H	120	26.369	−37.067	−28.308	1.00	52.94	O
HETATM	7680	O	HOH	H	121	6.784	−33.147	−16.101	1.00	53.52	Q
HETATM	7681	O	HOH	H	122	15.535	−47.621	−10.323	1.00	46.31	O
HETATM	7682	O	HOH	H	123	32.051	−111.111	−42.734	1.00	40.06	O
HETATM	7683	O	HOH	H	124	35.961	−110.552	−17.534	1.00	62.41	O
HETATM	7684	O	HOH	H	125	32.893	−37.178	−9.016	1.00	49.57	O
HETATM	7685	O	HOH	H	126	36.147	−33.604	2.775	1.00	45.74	O
HETATM	7686	O	HOH	H	127	1.635	−52.607	−4.981	1.00	38.75	O
HETATM	7687	O	HOH	H	128	13.187	−78.804	−9.386	1.00	44.14	O
HETATM	7688	O	HOH	H	129	36.477	−22.477	2.798	1.00	50.98	O
HETATM	7689	O	HOH	H	130	26.203	−39.200	−3.621	1.00	39.60	O
HETATM	7690	O	HOH	H	131	31.284	−35.751	4.627	1.00	31.11	O
HETATM	7691	O	HOH	H	132	12.838	−93.333	−44.729	1.00	49.54	O
HETATM	7692	O	HOH	H	133	32.760	−99.308	−22.724	1.00	41.49	O
HETATM	7693	O	HOH	H	134	33.316	−104.295	−22.771	1.00	36.04	O
HETATM	7694	O	HOH	H	135	18.705	−92.438	−26.542	1.00	32.30	O
HETATM	7695	O	HOH	H	136	27.095	−90.254	−27.427	1.00	49.28	O
HETATM	7696	O	HOH	H	137	5.051	−108.454	−30.351	1.00	48.04	O
HETATM	7697	O	HOH	H	138	11.053	−82.680	−28.616	1.00	37.08	O
HETATM	7698	O	HOH	H	139	20.941	−87.426	−12.382	1.00	44.41	O
HETATM	7699	O	HOH	H	140	25.690	−112.331	−15.752	1.00	35.91	O

Claims

1. A compound that can bind PRMT5 of the formula (I): Ring AA-M-Ring BB;

2. The compound of claim 1, wherein Ring AA is a monocyclic aryl moiety.

3. The compound of claim 1, wherein Ring AA is an optionally substituted, fused bicyclic heteroaryl moiety.

4. The compound of claim 1, wherein Ring AA is an unsubstituted, fused bicyclic heteroaryl moiety.

5. The compound of claim 1, wherein Ring AA is a phenyl moiety fused to a heterocyclic moiety.

6. The compound of claim 1, wherein Ring AA is a phenyl moiety fused to a heteroaryl moiety.

7. The compound of claim 1, wherein Ring AA is a phenyl moiety fused to a 5- or 6-membered heteroaryl moiety.

8. The compound of claim 1, wherein Ring BB is an optionally substituted, bicyclic heteroaryl moiety.

9. The compound of claim 1, wherein Ring BB is an optionally substituted, bicyclic heteroaryl moiety with 1-4 nitrogen atoms.

10. The compound of claim 1, wherein Ring BB is an unsubstituted bicyclic heteroaryl moiety.

11. The compound of claim 1, wherein Ring BB is optionally substituted tetrahydroisoquinoline.

12. The compound of claim 1, wherein Ring BB is unsubstituted tetrahydroisoquinoline.

13. The compound of claim 1, wherein Ring BB is optionally substituted isoindoline.

14. The compound of claim 1, wherein Ring BB is unsubstituted isoindoline.

15. The compound of claim 1, wherein Ring BB is an optionally substituted amino-aryl moiety.

16. The compound of claim 1, wherein Ring BB is optionally substituted benzylamine.

17. The compound of claim 1, wherein Ring BB is unsubstituted benzylamine.

18. The compound of claim 1, wherein M is a linker 4-8 atoms in length.

19. The compound of claim 1, wherein M is a linker 4 atoms in length.

20. The compound of claim 1, wherein M is a linker 5 atoms in length.

21. The compound of claim 1, wherein the atoms of M are selected from the group consisting of C, N, O, and S.

22. The compound of claim 1, wherein the atoms of M are selected from the group consisting of C, N, and O.

23. The compound of claim 1, wherein M comprises an amide moiety.

24. The compound of claim 1, wherein M comprises a hydroxyl moiety.

25. The compound of claim 1, wherein M comprises a sulfonamide moiety.

26. The compound of claim 1, wherein M comprises an ester moiety.

27. The compound of claim 1, wherein M provides a distance between Ring AA and Ring BB ranging from approximately 6 Angstroms to approximately 10 Angstroms.

28. The compound of claim 1, wherein L provides a distance between Ring AA and Ring BB ranging from approximately 8 Angstroms to approximately 9 Angstroms.

29. The compound of claim 1, wherein L allows for the planes of Ring AA and Ring BB to be at an angle ranging from 85° to approximately 95°.

30. A compound of the formula

31. The compound of claim 30, wherein Ry is an optionally substituted aliphatic moiety connected to the ortho position of the phenyl group.

32. The compound of claim 30, wherein Rz is a hydroxyl group.

33. The compound of claim 30, wherein Q is —C(O)N(R)—.

34. The compound of claim 30, wherein Ar′ is a monocyclic or bicyclic aromatic ring with one or two nitrogen.

35. The compound of claim 30, wherein Ar′ is

36. A method for the design and identification of a potential binding compound for protein arginine N-methyltransferase 5 (PRMT5) comprising the steps of: (a) generating, on a computer, a three-dimensional structure of methyltransferase PRMT5 having the structural coordinates of Table A;(b) identifying amino acid residues forming an active site in the three-dimensional structure of PRMT5 from step (a), wherein the active site comprises S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according to Table A;(c) generating a three-dimensional model of the active site;(d) designing and/or selecting a compound that potentially binds to the active site using the three-dimensional model of the active site; and(e) synthesizing and/or choosing the potential binding compound.

37. The method of claim 36, wherein the active site comprises S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580, according to Table A.

38. The method of claim 36, wherein the active site comprises S-adenosyl methionine (SAM) and amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581, according to Table A.

39. A method of identifying a binding compound of protein arginine N-methyltransferase 5 (PRMT5), the method comprising: computationally identifying a binding compound that binds to PRMT5 using the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according to Table A.

40. A method of identifying a binding compound of protein arginine N-methyltransferase 5 (PRMT5), the method comprising: computationally identifying a binding compound that binds to PRMT5 using the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580, according to Table A.

41. A method of identifying a binding compound of protein arginine N-methyltransferase 5 (PRMT5), the method comprising: computationally identifying a binding compound that binds to PRMT5 using the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581, according to Table A.

42. A method of identifying a binding compound of protein arginine N-methyltransferase 5 (PRMT5), the method comprising: a) providing a set of atomic coordinates for a PRMT5 as set forth in Table A; andb) identifying in silico a binding compound that binds to PRMT5 using the coordinates of step (a).

43. A method of identifying a drug candidate for the treatment of a disease, the method comprising: a) using the atomic coordinates set forth in Table A to form a three-dimensional structure of PRMT5;b) selecting a test compound having the best fit with the structure of PRMT5; andc) assaying the ability of the test compound to modulate PRMT5 activity,

44. A PRMT5 inhibitor having molecular dimensions compatible with the shape of a PRMT5-active site as defined by the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Glu435, Leu437, Glu444, and Phe580, according to Table A, wherein the compound has a biochemical IC50 for PRMT5 of less than 100 nM.

45. The PRMT5 inhibitor of claim 44, wherein the active site is defined by the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu319, Phe327, Lys333, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, and Phe580, according to Table A.

46. The PRMT5 inhibitor of claim 44, wherein the active site is defined by the atomic coordinates of S-adenosyl methionine (SAM) and amino acids Leu312, Leu319, Thr323, Tyr324, Phe327, Glu328, Lys333, Tyr334, Glu435, Leu437, Gly438, Ser439, Glu444, Val503, Ser578, Trp579, Phe580, and Pro581, according to Table A.

47. The PRMT5 inhibitor of claim 44, wherein the inhibitor is capable of undergoing a pi-cation interaction with SAM.

48. The PRMT5 inhibitor of claim 44, wherein the inhibitor is capable of undergoing a pi-stacking interaction with Phe327.

49. The PRMT5 inhibitor of claim 44, wherein the inhibitor is capable of interacting with Glu444

50. A compound that can bind a PRMT5 of the formula: Ring AA-M-Ring BB;whereinRing AA is an optionally substituted aromatic moiety;M is an aliphatic linker;wherein Ring BB is an aromatic moiety capable of undergoing a pi-cation interaction with S-adenosyl methionine (SAM) and capable of undergoing a pi-stacking interaction with Phe327 of PRMT5;wherein the planes of Ring AA and Ring BB are at between 75° and 105° relative to each other;wherein the compound has a biochemical IC50 for PRMT5 of less than 100 nM.

51. A composition comprising a PRMT5 and a compound of the formula: Ring AA-M-Ring BB;whereinRing AA is an optionally substituted aromatic moiety;is an aliphatic linker;wherein Ring BB is an aromatic moiety capable of undergoing a pi-cation interaction with SAM of the PRMT5-SAM complex and capable of undergoing a pi-stacking interaction with Phe327 of PRMT5;wherein the planes of Ring AA and Ring BB are at between 75° and 105° relative to each other;wherein the compound has a biochemical IC50 for PRMT5 of less than 100 nM.

52. A computer readable medium comprising the atomic coordinates of PRMT5-Compound A6, as set forth in Table A

53. The computer readable medium of claim 52 further comprising programming for displaying a molecular model of PRMT5-Compound A6

54. The computer readable medium of claim 52 further comprising programming for identifying a binding compound to PRMT5.

55. A crystal structure of PRMT5-Compound A6

56. A pharmaceutical composition comprising a compound of any one of claims 1-35, 50 or an inhibitor of claims 44-49, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient

57. A kit or packaged pharmaceutical comprising a compound of any one of claims 1-35, 50 or an inhibitor of claims 44-49, or a pharmaceutically acceptable salt thereof, and instructions for use thereof.

58. A method of inhibiting PRMT5 comprising contacting a cell with an effective amount of a compound of any one of claims 1-35, 50 or an inhibitor of claims 44-49, or a pharmaceutically acceptable salt thereof.

59. A method of altering gene expression comprising contacting a cell with an effective amount of a compound of any one of claims 1-35, 50 or an inhibitor of claims 44-49, or a pharmaceutically acceptable salt thereof.

60. A method of altering transcription comprising contacting a cell with an effective amount of a compound of any one of claims 1-35, 50 or an inhibitor of claims 44-49, or a pharmaceutically acceptable salt thereof.

61. The method of any one of claims 58-60, wherein the cell is in vitro.

62. The method of any one of claims 58-60, wherein the cell is in a subject.

63. A method of treating a PRMT5-mediated disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of any one of claims 1-35, 50 or an inhibitor of claims 44-49, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 56.

64. The method of claim 63, wherein the disorder is a proliferative disorder.

65. The method of claim 63, wherein the disorder is cancer.

66. The method of claim 65, wherein the cancer is hematopoietic cancer, lung cancer, prostate cancer, melanoma, or pancreatic cancer.

67. The method of claim 63, wherein the disorder is a metabolic disorder.

68. The method of claim 67, wherein the metabolic disorder is diabetes.

69. The method of claim 67, wherein the metabolic disorder is obesity.

70. The method of claim 63, wherein the disorder is a blood disorder.

71. The method of claim 70, wherein the disorder is sickle cell anemia.

72. The method of claim 70, wherein the disorder is β-thalessemia.