METHODS OF MAINTAINING OR INCREASING GROWTH OR COGNITIVE DEVELOPMENT

Abstract

One or more complex lipids including gangliosides to achieve particular health benefits including maintaining or increasing cognitive development or maintaining or increasing growth in a foetal, infant or child subject.

Description

Claims

1-47. (canceled)

48. A method for increasing growth of a foetal subject by administering a composition comprising one or more complex lipids to a mother during gestation, wherein the growth is brain weight of the foetal subject or brain ganglioside content of the foetal subject, wherein the one or more complex lipids comprises phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, sphingomyelin, and ganglioside, wherein the one or more complex lipids comprise more phosphatidylethanolamine than phosphatidylcholine by weight and/or more phosphatidylethanolamine than sphingomyelin by weight.

49. The method of claim 48, wherein the one or more complex lipids comprises one or more phospholipids, one or more sphingolipids, one or more sphingomyelins, one or more ceramides, one or more cerebrosides, one or more gangliosides, or any combination of any two or more thereof.

50. The method of claim 49, wherein the one or more gangliosides comprises GM3, GD3, or a mixture of at least GM3 and GD3.

51. The method of claim 48, wherein the one or more complex lipids comprises at least 0.1% gangliosides w/w on a dry basis.

52. The method of claim 48, wherein the composition comprises at least 2 mg gangliosides per 100 g.

53. The method of claim 52, wherein the composition comprises 5 mg to 20 mg gangliosides per 100 g.

54. The method of claim 48, wherein the one or more complex lipids comprises a milk fat extract.

55. The method of claim 54, wherein the milk fat extract comprises 15% to 99% by weight total lipid, 1% to 80% by weight phospholipid, 1% to 25% by weight phosphatidylcholine, 0.1% to 15% by weight phosphatidylinositol, 0.1% to 15% by weight phosphatidylserine, 1% to 30% by weight phosphatidylethanolamine, 0.5% to 25% by weight sphingomyelin, and 0.1 to 10% by weight ganglioside.

56. The method of claim 55, wherein the composition comprises at least 2 mg milk fat extract per 100 g.

57. The method of claim 55, wherein the composition comprises at least 5 mg milk fat extract per 100 g.

58. The method of claim 55, wherein the composition comprises at least 7.5 mg milk fat extract per 100 g.

59. A method for maintaining or increasing growth of a foetal subject, the method comprising providing a pregnant mother with a composition comprising one or more complex lipids and informing the mother that the composition will maintain or increase growth of the foetal subject, wherein the growth is brain weight of the foetal subject or brain ganglioside content of the foetal subject, wherein the one or more complex lipids comprises phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, sphingomyelin, and ganglioside, wherein the one or more complex lipids comprise more phosphatidylethanolamine than phosphatidylcholine by weight and/or more phosphatidylethanolamine than sphingomyelin by weight.

60. A method for maintaining or increasing growth of an infant subject by administering a composition comprising one or more complex lipids to an infant subject in need thereof, wherein the one or more complex lipids comprises phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, sphingomyelin, and ganglioside, wherein the one or more complex lipids comprise more phosphatidylethanolamine than phosphatidylcholine by weight and/or more phosphatidylethanolamine than sphingomyelin by weight.

61. The method of claim 60, wherein the growth is one or more of body weight, body length, and bone mineral density.

62. The method of claim 60, wherein the growth is the absolute growth or rate of growth with reference to weight, length, or height, while not increasing adiposity or decreasing bone density.