Claims
- 1. A method for the preparation of an alpha-amino acid compound having the structure of Formula 32:
- 2. The method of claim 1 wherein the hydrolyzing conditions comprise contacting the hydantoin compound with an acid to produce an acid hydrolyzate.
- 3. The method of claim 2 wherein the acid is selected from the group consisting of hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, trifluoroacetic acid, and phosphoric acid.
- 4. The method of claim 2 wherein the method further comprises treating the acid hydrolyzate with an ion exchange resin.
- 5. The method of claim 1 wherein the hydrolyzing conditions comprise contacting the hydantoin compound with a base to produce a base hydrolyzate.
- 6. The method of claim 5 wherein the base is selected from the group consisting of a hydrazine, a metal sulfide, a metal hydroxide, and a metal alkoxide
- 7. The method of claim 1 wherein R1, R5, R6, and R7 each is —H.
- 8. The method of claim 1 wherein R9 and R10 each is —H.
- 9. The method of claim 1 where the alpha-amino acid compound has the structure of Formula 34:
- 10. A method for the preparation of a hydantoin compound having the structure of Formula 35:
- 11. The method of claim 10 wherein the source of cyanide is hydrogen cyanide.
- 12. The method of claim 10 wherein the source of cyanide is a metal cyanide salt.
- 13. The method of claim 12 wherein the metal cyanide salt is selected from the group consisting of sodium cyanide, potassium cyanide, and lithium cyanide.
- 14. The method of claim 13 wherein the metal cyanide salt is sodium cyanide.
- 15. The method of claim 10 wherein R1, R5, R6 and R7 each is —H.
- 16. The method of claim 10 wherein R9 and R10 each is —H.
- 17. The method of claim 10 further comprising a chiral separation step.
- 18. The method of claim 17 wherein the hydantoin compound has the structure of Formula 33:
Parent Case Info
[0001] This application is a division of U.S. Ser. No. 09/816,575, which claims the benefit of priority of U.S. Provisional Patent Application No. 60/191,923 filed Mar. 24, 2000, herein incorporated by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60191923 |
Mar 2000 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09816575 |
Mar 2001 |
US |
Child |
10321969 |
Dec 2002 |
US |