Claims
- 1. A synthetic process, comprising converting a compound of formula 7a: ##STR71## wherein each R.sup.3 is independently an aryl group or an alkyl group, to a compound of formula 8a: ##STR72## wherein R.sup.4 is an alkyl group.
- 2. A process according to claim 1, further comprising converting a compound of formula 6: ##STR73## wherein each R.sup.3 is independently an aryl group or an alkyl group, to form the compound of formula 7a.
- 3. A process according to claim 2, further comprising converting a compound of formula 5: ##STR74## wherein each R.sup.3 is independently an aryl group or an alkyl group, to form the compound of formula 6.
- 4. A process according to claim 3, further comprising converting a compound of formula 4: ##STR75## wherein each R.sup.3 is independently an aryl group or an alkyl group, to form the compound of formula 5.
- 5. A process according to claim 4, further comprising converting a compound of formula 3: ##STR76## wherein R and R.sup.1 each is independently H, an alkyl group, or an aryl group, to form the compound of formula 4.
- 6. A process according to claim 5, further comprising converting a compound of formula 1: ##STR77## to a compound of formula 2: ##STR78## wherein R and R.sup.1 each is independently H, an alkyl group, or an aryl group, and each R.sup.2 is independently an alkyl group, a cycloalkyl group, an aryl group, a heteroaryl group, or a heterocycloalkyl group, and converting the compound of formula 2 to the compound of formula 3.
- 7. A process according to claim 1, further comprising converting a compound of formula 6a: ##STR79## wherein each X is independently a halogen, to form the compound of formula 7a.
- 8. A process according to claim 7, further comprising converting a compound of formula 5: ##STR80## wherein each R.sup.3 is independently an aryl group or an alkyl group, to form the compound of formula 6a.
- 9. A process according to claim 1, further comprising converting the compound of formula 8a to a compound of formula 9a: ##STR81## wherein R.sup.4 is an alkyl group.
- 10. A process according to claim 9, further comprising converting the compound of formula 9a to a compound of formula 10a: ##STR82##
- 11. A process according to claim 10, further comprising converting the compound of formula 10a to a compound of formula 11a: wherein Y.sup.- is a suitable salt anion.
- 12. A process according to claim 11, further comprising converting the compound of formula 11a to a compound of formula 12: ##STR83## and converting the compound of formula 12 to nelfinavir mesylate: ##STR84##
RELATED APPLICATION DATA
This application claims priority benefits under 35 U.S.C. .sctn. 119 based on U.S. Provisional patent appln. Ser. No. 60/025,515, filed Sep. 5, 1996. This provisional application is entirely incorporated herein by reference. Additionally, this application relates to the following U.S. patent applications:
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5705647 |
Babu et al. |
Jan 1998 |
|