Claims
- 1. A method of making a compound of Formula Ia
- 2. The method of claim 1 wherein A is
- 3. The compound:
- 4. The compound:
- 5. A method of making
- 6. A method of making
- 7. A method of making
- 8. A method of making
- 9. A method of making a compound of Formula I
- 10. The method of claim 9 wherein in step 1, the compound poly(4-vinylpyridine) is used a base.
- 11. The method of claim 9, wherein in step 2 the
- 12. The method of claim 9 wherein R3 is hydrogen, A is
- 13. The compound:
- 14. A method of making
- 15. A method of making a compound of Formula I
- 16. The compound:
- 17. A compound in accordance with claim 16 wherein R3 is hydrogen and C1-C6alkyl is ethyl.
- 18. A method of making
- 19. A method of resolving phenyl-(2-pyridyl)-methylamine to obtain (S)-phenyl-(2-pyridyl)-methylamine, (S)-(+)-α-methoxyphenylacetic acid salt, the method comprising the steps of:
a. reacting phenyl-(2-pyridyl)-methylamine with (S)-(+)-α-methoxyphenylacetic acid in isopropanol, which results in a precipitate being formed; and b. isolating the precipitate, which is (S)-phenyl-(2-pyridyl)-methylamine, (S)-(+)-α-methoxyphenylacetic acid salt.
- 20. The method of claim 19 wherein of the (S)-(+)-α-methoxyphenylacetic acid is present in the reaction in an amount in the range of about 0.5 equivalents with respect to the amine.
- 21. The method of claim 19 wherein the isolated precipitate is purified by recrystallization.
- 22. The method of claim 19 wherein the (S)-phenyl-(2-pyridyl)-methylamine, (S)-(+)-α-methoxyphenylacetic acid salt is converted to the (S)-phenyl-(2-pyridyl)-methylamine hydrochloride salt.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims priority of U.S. provisional application No. 60/224,366, filed Aug. 11, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60224366 |
Aug 2000 |
US |