Claims
- 1. A method of treating inflammation in a patient in need thereof comprising:
- administering to said patient a therapeutically effective amount of an injectable pharmaceutical composition comprised of:
- a pharmaceutically acceptable carrier; and
- a compound selected from the group consisting of:
- (a) a compound of formula III ##STR10## which compound binds to a selectin receptor; and (b) molecules having hydrogen bond donor groups equivalent to the circled groups of formula III with respect to their ability to form hydrogen bonds with a selectin receptor;
- wherein the selectin-binding compound selected from the group consisting and of (a) and (b) is present in the composition in an amount in the range of about 1% to about 95% by weight.
- 2. The method of claim 1, wherein the patient is a human and the selectin receptor is an ELAM-1 receptor.
- 3. The method of claim 1, wherein the selected compound is (b) a molecule having hydrogen bond donor groups equivalent to the circled groups of formula III and having an energetically preferred conformation schematically represented by the structure: ##STR11## or an equivalent three-dimensional configuration with respect to its ability to bind to a selectin receptor.
- 4. The method of claim 3, wherein the pharmaceutical composition is administered by intravenous injection.
CROSS-REFERENCE
This application is a continuation-in-part of our earlier filed application Ser. No. 07/683,458 filed Apr. 11, 1991, now U.S. Pat. No. 5,211,937, issued May 18, 1993, which is a continuation-in-part of our earlier application Ser. No. 07/637,868, filed Jan. 7, 1991, now U.S. Pat. No. 5,143,712, issued Sep. 1, 1992, which is a continuation in part of our earlier filed (now abandoned) application Ser. No. 07/613,113, filed Nov. 15, 1990, which is a continuation in part of our earlier application Ser. No. 07/559,836, filed on Jul. 30, 1990, now U.S. Pat. No. 5,211,936, issued May 18, 1993, all of which applications are incorporated herein by reference and to which applications we claim priority under 35 USC .sctn.120. This application is also related to and incorporates by reference in its entirety our earlier filed PCT application PCT/US91/05416 filed Jul. 30, 1991 to which application we claim priority, to the extent allowed, under 35 USC .sctn.119 and/or 365.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO9013300 |
Nov 1990 |
WOX |
Continuation in Parts (4)
|
Number |
Date |
Country |
Parent |
683458 |
Apr 1991 |
|
Parent |
637868 |
Jan 1991 |
|
Parent |
613113 |
Nov 1990 |
|
Parent |
559836 |
Jul 1990 |
|