Claims
- 1. A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment, comprising administering to said subject a compound of Formula I: ##STR6## wherein: X and Y are located in the para or meta positions and are each ##STR7## wherein: each R.sub.1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.1 groups together with --NCN-- to which they are attached form an imidazolinyl ring or tetrahydropyrimidinyl ring or two R.sub.1 groups together represent ##STR8## wherein m is from 1-3 and R.sub.7 is H or --CONHR.sub.8 NR.sub.9 R.sub.10, wherein R.sub.8 is loweralkyl, and R.sub.9 and R.sub.10 are each independently selected from the group consisting of H and lower alkyl;
- R.sub.2 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;
- n is a number from 0 to 2;
- R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, loweralkoxy, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and
- R.sub.5 and R.sub.6 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl;
- or a pharmaceutically acceptable salt thereof, in an amount effective to treat Pneumocystis carinii pneumonia.
- 2. The method according to claim 1, wherein said subject is afflicted with Pneumocystis carinii pneumonia.
- 3. The method according to claim 1, wherein said subject is at risk of developing Pneumocystis carinii pneumonia and said compound is administered in a prophylactically effective amount.
- 4. The method according to claim 1, wherein X and Y are in the para position.
- 5. The method according to claim 1, wherein X and Y are each ##STR9## two R.sub.1 groups together with --NCN-- to which they are attached form a tetrahydropyrimidinyl ring, R.sub.2 is H, n is 0, R.sub.3 is H, R.sub.4 is H, R.sub.5 is H, and R.sub.6 is H.
- 6. The method according to claim 1, wherein X and Y are each ##STR10## two R.sub.1 groups together with --NCN-- to which they are attached form a tetrahydropyrimidinyl ring, R.sub.2 is H, n is 0, R.sub.3 is H, R.sub.4 is loweralkoxy, R.sub.5 is H, and R.sub.6 is H.
- 7. The method according to claim 1, wherein said compound of Formula I is selected from the group consisting of 2,4-bis-(4-guanylphenyl)pyrimidine, 2,4-bis-(4-imidazolin-2-yl)pyrimidine, 2,4-bis-�(tetrahydropyrimidinyl-2-yl)phenyl!pyrimidine, 2-(4-�N-i-propylguanyl!phenyl)-4-(2-methoxy-4-�N-i-propylguanyl!phenyl)pyrimidine, and the pharmaceutically acceptable salts thereof.
RELATED APPLICATIONS
This application is a divisional of co-pending prior application Ser. No. 08/305,823, filed on Sep. 13, 1994, U.S. Pat. No. 5,521,189 and allowed on Nov. 6, 1995, entitled METHODS OF TREATING PNEUMOCYSTIS CARINII PNEUMONIA the disclosure of which is incorporated by reference herein in its entirety, which is a continuation-in-part of U.S. patent application Ser. No. 08/238,766, filed 6 May 1994.
Government Interests
The present invention was made with Government support under Grant Number UO1-A1-3363 from the National Institutes of Health. The Government has certain rights to this invention.
Foreign Referenced Citations (1)
Number |
Date |
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33 19 843 A1 |
Dec 1984 |
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Non-Patent Literature Citations (6)
Entry |
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Das, B.P., et al., Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)furans, J. Medicinal Chemistry 20:531 (1977). |
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Das, B.P., et al., Synthesis and Antitrypanosomal Activity of Some Bis(4-guanylphenyl) Five- and Six-Membered Ring Heterocycles, J. Medicinal Chemistry 23:578 (1980). |
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Divisions (1)
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305823 |
Sep 1994 |
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Continuation in Parts (1)
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238766 |
May 1994 |
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