Claims
- 1. A method for treating sepsis, comprising administrating to a subject in need thereof an effective amount of a compound of formula (I):
- 2. The method of claim 1, wherein A is H.
- 3. The method of claim 2, wherein Ar1 is phenyl.
- 4. The method of claim 3, wherein Ar2 is phenyl.
- 5. The method of claim 4, wherein each of R1 and R2 is H.
- 6. The method of claim 3, wherein Ar2 is furyl.
- 7. The method of claim 7, wherein each of R1 and R2 is H.
- 8. The method of claim 1, wherein A is (CH2)n
- 9. The method of claim 8, wherein Ar1 is phenyl.
- 10. The method of claim 9, wherein Ar2 is phenyl.
- 11. The method of claim 10, wherein Ar3 is phenyl.
- 12. The method of claim 11, wherein n is 0 or 1.
- 13. The method of claim 12, wherein one of R1, R2, R3, R4, R5, and R6 is COOH, COO—C1˜C6 alkyl, CH2OH, CN, NO2, or halogen.
- 14. The method of claim 9, wherein Ar2 is furyl.
- 15. The method of claim 14, wherein Ar3 is phenyl.
- 16. The method of claim 15, wherein n is 0 or 1.
- 17. The method of claim 16, wherein one of R1, R2, R3, R4, R5, and R6 is COOH, COO—C1˜C6 alkyl, CH2OH, CN, NO2, or halogen.
- 18. The method of claim 9, wherein Ar3 is phenyl.
- 19. The method of claim 9, wherein n is 0 or 1.
- 20. The method of claim 8, wherein Ar1 is thienyl.
- 21. The method of claim 20, wherein Ar2 is furyl.
- 22. The method of claim 21, wherein Ar3 is phenyl.
- 23. The method of claim 22, wherein n is 0 or 1.
- 24. The method of claim 23, wherein one of R1, R2, R3, R4, R5, and R6 is COOH, COO—C1˜C6 alkyl, CH2OH, CN, NO2, or halogen.
- 25. The method of claim 1, wherein the compound is
- 26. A compound of formula (I)
- 27. The compound of claim 26, wherein A is
- 28. The compound of claim 27, wherein Ar1 is phenyl.
- 29. The compound of claim 28, wherein Ar2 is furyl.
- 30. The compound of claim 29, wherein Ar3 is phenyl.
- 31. The compound of claim 30, wherein each of R1, R2, R5, and R6 is H.
- 32. The compound of claim 31, wherein one of R3 and R4 is H.
- 33. The compound of claim 32, wherein n is 0 or 1.
- 34. The compound of claim 33, wherein X is CH2, Y must be OC(O)CH2CH2C(O)O, and Z is H in the other of R3 and R4.
- 35. A method for inhibiting vascular cell apoptosis comprising administrating to a subject in need thereof an effective amount of a fused pyrazolyl compound of formula (I):
RELATED APPLICATIONS
[0001] This application claims priority to U.S. provisional application No. 60/351,788, filed on Jan. 25, 2002, the contents of which are incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60351788 |
Jan 2002 |
US |