Claims
- 1. A process for making the compound UK-61,689 having the formula (I) ##STR3## which comprises fermenting, in an aqueous medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic conditions, a strain belonging to the genus Actinomadura, wherein said strain is a mutant obtained by mutating a UK-58,852 producing strain of Actinomadura roseorufa and which mutant produces UK-61,689 upon cultivation in said aqueous nutrient medium, until a recoverable amount of compound UK-61,689 accumulates in the whole broth; and recovering compound UK-61,689.
- 2. A process according to claim 1 wherein the compound of formula (I) is recovered from the fermentation broth in association with mycelium.
- 3. A process for making the compound UK-61,689 having the formula (I) ##STR4## which comprises fermenting Actinomadura roseorufa which produces compound UK-61,689 in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic fermentation conditions until a recoverable amount of compound UK-61,689 accumulates in the whole broth; and recovering compound UK-61,689.
- 4. A process according to claim 3 wherein the compound of formula (I) is recovered from the fermentation broth in association with mycelium.
- 5. A process according to claim 3 which comprises cultivating Actinomadura roseorufa ATCC 53,665 or ATCC 53,674.
- 6. A process according to claim 3 which comprises cultivating Actinomadura roseorufa ATCC 53,664.
Parent Case Info
This is a continuation of application Ser. No. 07/935,673, filed Aug. 25, 1992, now abandoned, which is a continuation of application Ser. No. 07/506,722, filed Apr. 9, 1990, now abandoned, which is a continuation of application Ser. No. 07/113,563, filed on Oct. 26, 1987, abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4148822 |
Celmer et al. |
Apr 1979 |
|
4407946 |
Labeda et al. |
Oct 1983 |
|
4804680 |
Goudie |
Feb 1989 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
169011 |
Jan 1986 |
EPX |
186787 |
Aug 1987 |
JPX |
Continuations (3)
|
Number |
Date |
Country |
Parent |
935673 |
Aug 1992 |
|
Parent |
506722 |
Apr 1990 |
|
Parent |
113563 |
Oct 1987 |
|