Claims
- 1. A microfluidic device for analyzing fluids, comprising:a body structure; means located within said body structure for introduction of a sample fluid and a reagent fluid; a flow channel having a first end, coupled to said introduction means, and a second end, for allowing flowing contact between said sample fluid and said reagent fluid along said flow channel such that a reaction between said fluids can occur, with said reaction causing formation of particles within said flow channel into visibly detectable clusters; and separation means, coupled to said second end of said flow channel, having varying dimensions to separate particle clusters of differing sizes.
- 2. The device of claim 1, wherein said sample fluid and said reagent fluid are introduced into said channel such that each forms a fluid layer contiguously flowing in parallel.
- 3. The device of claim 2, wherein said flowing layers are oriented such that one layer flows above the other layer, whereby allowing particles to settle from said upper layer to said lower layer.
- 4. The device of claim 3, wherein particles settling from said upper fluid layer combine with particles in said lower layer to cause a detectable reaction within said channel.
- 5. The device of claim 1, further comprising means for moving said fluids from said introduction means through said device wherein said fluid moving means requires no electrical or mechanical fluid driver.
- 6. The device of claim 5, wherein said fluid moving means is selected from the group consisting of: hydrostatic pressure, capillary action, fluid absorption, gravity, and vacuum.
- 7. The device of claim 1, wherein said flowing channel comprises a transparent channel.
- 8. The device of claim 7, wherein said transparent flow channel has microfluidic dimensions.
- 9. The device of claim 1, wherein said clusters are formed by agglutination.
- 10. The device of claim 1, wherein said clusters are formed by coagulation.
- 11. A microfluidic device for analyzing blood, comprising:a body structure; means located within said body structure for introduction of a whole blood sample and a reagent sample; a whole blood sample; a reagent sample containing a specific blood type antiserum; and a flow channel having a first end, coupled to said introduction means, and a second end, for allowing flowing contact between said whole blood sample and said reagent sample along said flow channel such that a reaction between said samples can occur, with said reaction causing formation within said flow channel of visibly detectable clusters; wherein the presence of visibly detectable clusters within said flow channel indicates that the blood type of said blood sample matches the specific blood type antiserum within said reagent sample.
- 12. The device of claim 11, wherein said whole blood sample and reagent sample are introduced into said channel such that each forms a fluid layer contiguously flowing in parallel.
- 13. The device of claim 12, wherein said flowing layers are oriented such that one layer flows above the other layer, whereby allowing particles to settle from said upper layer to said lower layer.
- 14. The device of claim 13, wherein said whole blood sample stream flows above said reagent sample stream.
- 15. The device of claim 14, wherein said formed detectable clusters clog said flow channel to inhibit flow.
CROSS-REFERENCE TO RELATED APPLICATION
This patent application takes priority from U.S. Provisional Application Serial No. 60/189,163, filed Mar. 14, 2000, which application is incorporated herein in its entirety by reference.:
US Referenced Citations (9)
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO9009596 |
Dec 1997 |
WO |
WO0022436 |
Apr 2000 |
WO |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/189163 |
Mar 2000 |
US |