Claims
- 1. Micronized particles suitable for inhalation comprising an active pharmaceutical substance which particles are made by solubilizing a poly-L(-)lactide having a molecular weight in the range from about 1000 to about 10,000 with an active pharmaceutical substance, removing the solvent and then jet grinding the resulting solid material to produce particles having an average diameter of about 1 .mu.m to about 10 .mu.m.
- 2. The micronized particles according to claim 1 wherein the poly-L(-)-lactide has a molecular weight of from about 1000 to about 5000.
- 3. The micronized particles according to claim 1 wherein the active pharmaceutical substance is selected from the group consisting of anticholinergics, antiallergics, steroids and .beta.-sympathomimetics.
- 4. The micronized particles according to claim 1 wherein the poly-L(-)-lactide has a molecular weight of from about 1000 to about 5000 and the active pharmaceutical substance is fenoterol.
- 5. Micronized particles suitable for inhalation comprising an active pharmaceutical substance which particles are made by solubilizing a biodegradable polymer having a molecular weight of from about 1000 to about 10,000 with an active pharmaceutical substance, removing the solvent and then jet grinding the resulting solid material to produce particles having an average diameter of about 1 .mu.m to about 10 .mu.m.
- 6. The micronized particles according to claim 5 wherein the biodegradable polymer is a hydroxycarboxylic acid selected from the group consisting of glycolide, lactide, methyl-glycolide, dimethylglycolide, diethyglycolide and dibutylglycolide.
- 7. The micronized particles according to claim 6 wherein the biodegradable polymer has a molecular weight of from about 1,000 to about 5,000.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3917617.7 |
May 1989 |
DEX |
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Parent Case Info
This is a continuation of application Ser. No. 08/076,591, filed Jun. 14, 1993, abandoned Jul. 4, 1995 which is a continuation of application Ser. No. 07/952,385, filed Sep. 28, 1992 (abandoned) Jun. 12, 1992 which is a continuation of application Ser. No. 07/930, 819, filed Feb. 4, 1992 (abandoned) Sep. 30, 1992 which is a continuation of application Ser. No. 07/531,190, filed May 31, 1990 (abandoned) Feb. 2, 1992.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4810697 |
Speiser et al. |
Mar 1989 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
0257915 |
Nov 1987 |
EPX |
Continuations (4)
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Number |
Date |
Country |
Parent |
76591 |
Jun 1993 |
|
Parent |
952385 |
Sep 1992 |
|
Parent |
830819 |
Feb 1992 |
|
Parent |
531190 |
May 1990 |
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