Patent Grant
11110259
The subject matter described herein relates generally to a method and delivery system for drug delivery using microprojections, and more specifically to applicators for applying an array of microprojections.
Arrays of microneedles were proposed as a way of administering drugs through the skin in the 1970s, for example in U.S. Pat. No. 3,964,482. Microneedle or microstructure arrays can facilitate the passage of drugs through or into human skin and other biological membranes in circumstances where ordinary transdermal administration is inadequate. Microstructure arrays can also be used to sample fluids found in the vicinity of a biological membrane such as interstitial fluid, which is then tested for the presence of biomarkers.
In recent years it has become more feasible to manufacture microstructure arrays in a way that makes their widespread use financially feasible. U.S. Pat. No. 6,451,240 discloses some methods of manufacturing microneedle arrays. If the arrays are sufficiently inexpensive, for example, they may be marketed as disposable devices. A disposable device may be preferable to a reusable one in order to avoid the question of the integrity of the device being compromised by previous use and to avoid the potential need of resterilizing the device after each use and maintaining it in controlled storage.
In addition to cost, integrity and sterility, a further issue with microneedle arrays is bioavailability of the active agent. An intravenous injection delivers a precise quantity of an active agent to the circulation. A subcutaneous or intramuscular injection delivers a precise quantity of an active agent into the tissue, but the quantity of active agent delivered to the circulation and the rate at which active ingredient is delivered are affected by the type of surrounding tissue, circulation, and possibly other factors. When a drug is delivered orally, the resulting blood levels may exhibit substantial variation among patients due to metabolism and other factors, but minimal therapeutic levels can be assured for most patients, for example, because the rate of metabolism has an upper limit and because there is long experience with the absorption of many drugs from oral formulations. When a drug is delivered to unmodified skin by a conventional transdermal patch, the bypassing of the hepatic circulation may lessen the effect of liver metabolism on bioavailability. On the other hand, with a conventional transdermal patch, differences in skin permeability are an additional factor leading to differences in bioavailability.
Microneedles manipulate the permeability of the skin with respect to the active agent. Variability in the permeability enhancement created by different applications of the microneedles will result in variations in the rate of transfer through the skin, the amount transferred through the skin and the bioavailability. Variability of skin permeability enhancement on the application of a microneedle array can result from application on different patients. Particular concern exists, of course, if the enhancement is small in particular patient populations so that the administration of the drug will not produce a therapeutically effective dosing (e.g., adequate blood levels) in those populations. Concern may arise also if the enhancement is sometimes undesirably small in a patient, even if at other times the enhancement is as expected in that patient, depending on details of how and where the microneedle array is applied.
A typical microneedle array comprises microneedles projecting from a base of a particular thickness, which may be of any shape, for example square, rectangular, triangular, or circular. The microneedles themselves may have a variety of shapes. While an array could be pressed by hand into skin, it has also been proposed to use a variety of devices to hold the microneedle array as it is being applied or to facilitate in one way or another the process of microneedle array application to the skin or other biological membrane. Such devices may broadly be referred to as “applicators.” Applicators may for example reduce the variations in force, velocity, and skin tension that occur when a microneedle array is pressed by hand into the skin. Variations in force, velocity and skin tension can result in variations in permeability enhancement.
In some applications of microneedle arrays, they may be applied to the skin or other biological membrane in order to form microchannels and then are more or less immediately withdrawn. In other applications the microneedle array may be held in place for a longer period of time. The design of the applicator may naturally be influenced by how long the microneedles are expected to stay in place.
Applicators for microneedles comprising components which have two stable states have been described in U.S. Published Patent Application No. 2008/0183144. The existence of two stable states is a feature generally desired in an applicator because the energy difference between the two stable states can allow each use of the applicator to employ a fixed amount of energy in order to cause penetration, improving reproducibility.
In some other prior art applicator designs, the energy storage element, such as a spring or elastic element, may exert forces on one or more components of the applicators, leading to dimensional distortion and creep over an extended period of time. These effects are undesirable as they lead to variations in the applicator geometry and a loss in the stored elastic energy over time. Therefore, there is a need for an applicator which has energy storage elements that do not exert forces on one or more components of the applicator and/or has elements that reduces or eliminates the stress being applied to components of the applicator to eliminate or reduce dimensional distortion and creep.
In some other prior art applicator designs, a plunger is released at one or more points by pushing several projections away from contact with the plunger. The release may not be simultaneous resulting in tilting of the plunger during release which results in poor penetration of the microstructure array (MSA) into skin. Therefore, there is a need for an applicator that releases the plunger without adversely affecting the trajectory of the plunger.
In the use of microneedle arrays, particularly when the arrays are kept in place for a prolonged period of time, devices to transport the drug substance to the skin may be employed. A very simple such device may, for example, comprise a reservoir for liquid or solid drug substance which is kept in contact with the base, with the liquid drug substance flowing through small apertures in the base or by diffusion when solid drug substance is used. Another device suitable for delivering the drug substance to skin is described in U.S. Published Patent Application No. 2005/0094526. Rotary applicators have been disclosed in U.S. Published Patent Application No. 2004/0087992. There is some disclosure relating to applicators, for example, in U.S. Pat. Nos. 6,537,242, 6,743,211 and 7,087,035.
There is a need in the art for applicators and related devices suitable for use with microneedle arrays, for example, in order to assist in making the process of drug delivery more user friendly and uniform across patients and for different applications to the same patient.
The foregoing examples of the related art and limitations related therewith are intended to be illustrative and not exclusive. Other limitations of the related art will become apparent to those of skill in the art upon a reading of the specification and a study of the drawings.
The following aspects and embodiments thereof described and illustrated below are meant to be exemplary and illustrative, not limiting in scope.
In one aspect, an applicator comprising a plate member, a blocking element, a plunger, an energy-storing element, and an actuating member is provided. In an embodiment, the plate member is a rigid plate member having an upper surface and a lower surface. In a further embodiment, the plate member includes at least one opening. The blocking element is in contact with the upper surface of the plate member and is capable of moving between a first position and a second position in an embodiment. In another embodiment, the plunger has a proximal end, a distal end and a shaft extending therebetween. The proximal end of the shaft may be at least partially retained by the blocking member in its first position. In an embodiment, the energy-storing element is positioned between the lower surface of the plate member and the distal end of the plunger. In a further embodiment, the actuating member has an external surface for application of a force and at least one surface in mechanical communication with the blocking element when the blocking element is in the first position. In another embodiment, the actuating member moves the blocking element from the first position to the second position when a force is applied to the external surface of the actuating member. The energy-storing element is released as the blocking element is moved from its first position to its second position.
In an aspect, the applicator further comprises at least one microprojection positioned on a bottom surface of the plunger distal end. In another embodiment, the at least one microprojection is a microprojection array, a hypodermic needle or a trocar. In a further embodiment, the microprojection array comprises a plurality of dissolvable or erodible microprojections. In other embodiments, at least a portion of the plurality of microprojections is detachable from the microprojection array. In yet another embodiment, the at least one microprojection includes at least one therapeutic agent.
In an embodiment, the applicator further comprises at least one flexure element in mechanical communication with the blocking element. In another embodiment, the flexure element directs the blocking element into the plunger in the blocking element first position.
In an embodiment, the actuating member causes the blocking element to have a linear displacement. In another embodiment, the actuating member causes the blocking element to have a rotational displacement.
In an embodiment, the energy-storing element is an elastic energy element. In another embodiment, the elastic energy element is selected from a compression spring, a coil spring, or a wave spring.
In an embodiment, the plunger proximal end is dimensioned to be retained by the blocking element in its first position. In a further embodiment, the plunger proximal end is retained by the blocking element in its first position by a ledge at least partially circumscribing the plunger shaft.
In an embodiment, the plunger shaft has a length and the energy-storing element is selected to provide a force on the plunger that causes the plunger to travel a distance longer than the length of the shaft.
In an embodiment, the at least one opening of the plate has a shape selected from circular, oval, rectangular, and square.
In an embodiment, the applicator further comprises a housing member. In another embodiment, the housing member includes an opening through which an external surface of the actuating member can be accessed. In a further embodiment, the housing opening is sized to receive at least a part of the external surface of the actuating member. In another embodiment, the housing includes a surface on which an adhesive is or can be applied, to secure the housing to a subject. In a further embodiment, the adhesive layer at least partially surrounds the at least one microprojection. In yet another embodiment, the length of the plunger shaft is such that it extends beyond the surface on which the adhesive is or can be applied.
In an embodiment, the applicator further comprises comprising a backing member positioned on a distal surface of the plunger distal end, wherein the backing member comprises the at least one microprojection. In a further embodiment, the backing member is detachable from the plunger distal end. In another embodiment, the backing member comprises a support layer adjacent the distal surface of the plunger distal end and an adhesive layer, wherein the at least one microprojection is positioned distal to the adhesive layer. In yet another embodiment, the at least one microprojection is a microprojection array positioned distal to the adhesive layer.
In embodiments, at least the plate and the plunger are formed from a material with an elastic modulus between about 0.5 to 500 KSI. In other embodiments, at least the plate and the plunger are formed from a metal. In a further embodiment, at least the blocking element is formed from a material with an elastic modulus between about 0.5 to 500 KSI. In yet another embodiment, the blocking element is formed from a metal. In embodiments, the metal is selected from stainless steel, carbon steel, titanium, and alloys thereof.
In an embodiment, the applicator further comprises a damper positioned between the energy-storing element and a proximal surface of the plunger distal end.
In a further aspect, a method for delivering at least one therapeutic agent to a subject is contemplated. In an embodiment, the method comprises applying a microprojection array included on a distal end of an applicator plunger to a subject's skin site; contacting an external surface of the applicator actuating member to actuate the actuator from a first position to a second position where the actuator is in mechanical communication with a blocking element; moving the blocking element from a first position in contact with a proximal end of the plunger to a second position; releasing the plunger from a first position in contact with the blocking member to a second position; releasing an energy-storing element to deploy the plunger into contact with a subject's skin; and delivering the at least one therapeutic agent from the microprojection array to the subject. In another embodiment, the method further comprises adhering the applicator to the subject's skin. In a further embodiment, moving the blocking element effects movement of the plunger from a retracted position to a deployed position. In another embodiment, contacting the external surface of the actuating member effects movement of the plunger from a retracted position to a deployed position. In a further embodiment, the plunger in the deployed position has an equilibrium position such that the distal end of the plunger on which the microprojection array is affixed is positioned below a surface of the skin. In yet another embodiment, the equilibrium position is about 0.03-0.2 inches below the surface of the skin of the subject. In another embodiment, the method further comprises detaching a backing member such that the backing member and the microprotrusion array are retained on the subject's skin.
In another aspect, an applicator comprising a planar plate having an upper surface and a lower surface and at least one opening; a planar flexure element in contact with the upper surface of the plate member, the flexure element (i) having a gap capable of moving between first and second positions and (ii) being positioned to align the gap with the opening in the plate member; a plunger slidably disposed within the aligned gap and opening; an energy-storing element positioned between the lower surface of the plate member and the distal end of the plunger; and an actuating member. In an embodiment, the plunger has a shaft with a distal end on which at least one microstructure can be retained. In a further embodiment, the plunger has a proximal end dimensioned such that the proximal end is retained by the gap when the gap is in its first position and the proximal end passes through the gap in its second position. In other embodiments, the actuating member has an external surface and a polyhedral-shaped member. In yet another embodiment, the polyhedral-shaped member is dimensioned to move the gap between its first and second positions when the external surface of the actuating member is contacted with sufficient force to effect release of the energy storing element. In further embodiments, the polyhedral-shaped member comprises between 2-8 faces. In even further embodiments, the polyhedral-shaped member has a gap dimensioned to receive the proximal end of the plunger.
In an embodiment, the energy-storing element is an elastic energy element. In other embodiments, the elastic energy element is selected from a compression spring, a coil spring, and a wave spring.
In an embodiment, the proximal end of the plunger is dimensioned to be retained by the gap in its first position by a ledge at least partially circumscribing the plunger shaft.
In an embodiment, the plate member opening has a shape selected from circular, oval, rectangular, and square. In another embodiment, the opening is centrally located on the plate.
In an embodiment, at least the flexure element and the plunger are formed from a material having an elastic modulus between about 0.5 to 500 KSI. In other embodiments, the material is a metal. In further embodiments, the metal is selected from stainless steel, carbon steel, titanium, and alloys thereof.
In embodiments, the applicator further comprises a housing member with an opening through which the external surface of the actuating member can be received. In other embodiments, the housing includes a surface on which an adhesive is or can be applied to secure the housing to a subject.
In embodiments, the plunger shaft has a length and the energy-storing element is selected to provide a force on the plunger that causes the plunger to travel a distance longer than the length of the shaft. In further embodiments, the length of the plunger shaft is such that it extends beyond the surface on which the adhesive is or can be applied.
In embodiments, the at least one microprojection is a microprojection array, a hypodermic needle or a trocar. In additional embodiments, the microprojection array comprises a plurality of dissolvable or erodible microprojections. In further embodiments, the plurality of microprojections includes a therapeutic agent. In even further embodiments, at least a portion of the plurality of microprojections is detachable from the microprojection array. In yet further embodiments, the applicator further comprises a backing member positioned on a bottom surface of the plunger distal end, wherein the backing member comprises the at least one microprojection. In other embodiments, the backing member is detachable from the plunger distal end. In additional embodiments, the backing layer comprises a support layer adjacent a distal surface of the plunger distal end and an adhesive layer, wherein the at least one microprojection is positioned distal to the adhesive layer. In further embodiments, the at least one microprojection is a microprojection array positioned distal to the adhesive layer. In even further embodiments, the adhesive at least partially surrounds the at least one microprojection.
In embodiments, the applicator further includes a damper positioned between the energy-storing element and a proximal surface of the plunger distal end.
In yet another aspect, a method for delivering a therapeutic agent is contemplated. In an embodiment, the method comprises applying a microprojection array affixed to an applicator; contacting the external surface of the actuating member to actuate the actuator from a first position to a second position, whereby a gap is moved from the first position to the second position; releasing the plunger from a restrained position to a deployed position in contact with the subject's skin; and delivering the therapeutic agent from the microprojection array to the subject. In an embodiment, the microprojection array is affixed to the distal end of a plunger. In embodiments, the method further comprises adhering the applicator to the subject's skin. In additional embodiments, the microprojection array comprises a plurality of microprojections, and in the deployed position, the plunger has an equilibrium position such that the distal end of the plunger on which at least a portion of the plurality of microprojections are positioned below the surface of the skin. In further embodiments, the equilibrium position is about 0.03-0.2 inches below the surface of the skin of the subject.
In an embodiment, deploying the plunger further comprises detaching the backing member such that the backing member and the microprotrusion array are retained on the subject's skin.
Additional embodiments of the present devices, apparatuses, methods, and the like, will be apparent from the following description, drawings, examples, and claims. As can be appreciated from the foregoing and following description, each and every feature described herein, and each and every combination of two or more of such features, is included within the scope of the present disclosure provided that the features included in such a combination are not mutually inconsistent. In addition, any feature or combination of features may be specifically excluded from any embodiment of the present invention. Additional aspects and advantages of the present devices, apparatuses, and methods are set forth in the following description and claims, particularly when considered in conjunction with the accompanying examples and drawings.
It will be appreciated that the thicknesses and shapes for the various applicators and microstructure arrays have been exaggerated in the drawings to facilitate understanding of the device. The drawings are not necessarily “to scale.”
Various aspects now will be described more fully hereinafter. Such aspects may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey its scope to those skilled in the art.
The practice of the present disclosure will employ, unless otherwise indicated, conventional methods of chemistry, biochemistry, and pharmacology, within the skill of the art. Such techniques are explained fully in the literature. See, e.g.; A. L. Lehninger, Biochemistry (Worth Publishers, Inc., current addition); Morrison and Boyd, Organic Chemistry (Allyn and Bacon, Inc., current addition); J. March, Advanced Organic Chemistry (McGraw Hill, current addition); Remington: The Science and Practice of Pharmacy, A. Gennaro, Ed., 20th Ed.; Goodman & Gilman The Pharmacological Basis of Therapeutics, J. Griffith Hardman, L. L. Limbird, A. Gilman, 10th Ed.
Where a range of values is provided, it is intended that each intervening value between the upper and lower limit of that range and any other stated or intervening value in that stated range is encompassed within the disclosure. For example, if a range of 1 μm to 8 μm is stated, it is intended that 2 μm, 3 μm, 4 μm, 5 μm, 6 μm, and 7 μm are also explicitly disclosed, as well as the range of values greater than or equal to 1 μm and the range of values less than or equal to 8 μm.
As used in this specification, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a “polymer” includes a single polymer as well as two or more of the same or different polymers; reference to an “excipient” includes a single excipient as well as two or more of the same or different excipients, and the like.
In describing and claiming the present invention, the following terminology will be used in accordance with the definitions described below.
In discussing the applicators and arrays, the term “downward” is sometimes used to describe the direction in which microprotrusions are pressed into skin and “upward to describe the opposite direction. However, those of skill in the art will understand that the applicators can be used where the microprotrusions are pressed into skin at an angle to the direction of the earth's gravity, or even in a direction contrary to that of the earth's gravity. In many applicators described herein, the energy for pressing the microprotrusions is provided primarily by an energy-storage member and so efficiency is not much affected by the orientation of the skin relative to the earth's gravity.
The terms “microprotrusion”, “microprojection”, “microstructure” or “microneedle” are used interchangeably herein to refer to elements adapted to penetrate or pierce at least a portion of the stratum corneum or other biological membranes. For example, illustrative microstructures may include, in addition to those provided herein, microblades as described in U.S. Pat. No. 6,219,574, edged microneedles as described in U.S. Pat. No. 6,652,478, and microprotrusions as described in U.S. Patent Publication No. U.S. 2008/0269685.
The term “microprotrusion array” for purposes herein is intended to denote a two-dimensional or a three-dimensional arrangement of microprotrusions, microprojections, or microneedles. The arrangement may be regular according to a repeating geometric pattern or it may be irregular.
“Optional” or “optionally” means that the subsequently described circumstance may or may not occur, so that the description includes instances where the circumstance occurs and instances where it does not.
“Substantially” or “essentially” means nearly totally or completely, for instance, 80-85%, 80-90%, 80-95%, 85-90%, 85-95%, 90-95% or greater of some given quantity.
In this application reference is often made for convenience to “skin” as the biological membrane which the microneedles penetrate. It will be understood by persons of skill in the art that in most or all instances the same inventive principles apply to the use of microneedles to penetrate other biological membranes such as, for example, those which line the interior of the mouth or biological membranes which are exposed during surgery. In other embodiments, the inventive principles may apply to the use of microneedles for cell walls. For example, the microneedles described herein may be used to treat a condition of the skin where certain cells that present on the surface are targeted by the microneedles.
“Transdermal” refers to the delivery of an agent into and/or through the skin or for local and/or systemic therapy. The same inventive principles apply to administration through other biological membranes such as those which line the interior of the mouth, gastro-intestinal tract, blood-brain barrier, or other body tissues or organs or biological membranes which are exposed or accessible during surgery or during procedures such as laparoscopy or endoscopy.
Before describing the present subject matter in detail, it is to be understood that this invention is not limited to specific materials or device structures, as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting.
In one aspect, an applicator for delivery of a needle, microneedle, microprojection, microstructure, or arrays thereof is described herein. The applicator comprises an actuator or actuating member, a blocking element or member, a plunger or piston, a plate or holder having at least one opening, and an energy-storing element. The applicator operates by applying a force to the actuating member above a threshold to release the plunger which is retained by the blocking member or element.
The applicator 10 includes a planar plate member or holder 12 having an upper or proximal surface 34 and a lower, under, or distal surface 36. The plate member has at least one opening 22 extending through the plate. The plate member may be flexible, rigid or substantially rigid. Preferably, the plate member has sufficient mechanical strength and/or is sufficiently rigid to constrain, along with a plunger distal end 28, an energy storage element 20 as describe more fully below. The at least one opening is dimensioned to allow at least a portion of a plunger or piston 16 to pass therethrough. In one embodiment, the at least one opening has a suitable dimension for the plunger to be slidably accommodated therein. A blocking or retaining element 14 is positioned adjacent the proximal surface of the plate at or near the at least one opening. The blocking element is capable of moving from a first position 38 as shown in
The applicator further includes a plunger, piston or other elongate structure 16 having a central post or shaft 26 with a proximal end or portion 24 and a distal end or portion 28. The shaft preferably extends at least partially between the proximal and distal ends or portions. The proximal end of the plunger is preferably sized and shaped so that it is at least partially slidably positionable through the at least one opening in the plate. It will be appreciated that the plunger may have any suitable shape or size. As shown at least in
As the actuator is moved from the first position 44 (
Pressure may be applied to move the actuating member 18 from its first position 44 to its second position 46 by any suitable means including manual or mechanical. Where the pressure is manually applied, the actuating member has an external surface that is suitable for contact by a user or otherwise includes structure that allows a user to apply the appropriate pressure to the actuating member. In non-limiting embodiments, a force of about 0.5-10 lb is applied to the actuating member.
The force needed to actuate the device is that required to move the actuating member from a first position to a second position and therefore move the blocking member from a first position to a second position. This force depends on their precise dimensions and the material characteristics (e.g., Young's modulus) of the material out of which they are made. In other embodiments, the force depends on the coefficient of friction, contact force, and/or mechanical advantage. The coefficient of friction may be modified by using finishes and/or coatings. The contact force depends on the spring constant and the energy stored in the energy storing element. Mechanical advantage depends on the design elements and their precise dimensions.
The bottom surface 30 of the plunger 16 further includes at least one needle, a microprojection array, a passive transdermal patch, or other delivery device for transdermal administration of one or more therapeutic agents. In an exemplary embodiment, a microprojection array 48 is affixed, attached, adhered to, or integral with the bottom surface 48 of the plunger. In one embodiment, the delivery device is removably attached to the plunger distal surface. General features for microprojection arrays are described, for example, in U.S. Publication Nos. 2008/0269685, 2011/0276028, and U.S. Pat. Nos. 7,416,541, 7,578,954, 7,108,681, each of which are incorporated herein by reference. In embodiments, the microprojection is a hypodermic needle or a trocar. In further embodiments, the microprojection array comprises a plurality of microprojections, at least some of which are dissolvable or erodible microprojections. In further embodiments, at least some of the microprojections include at least one therapeutic agent. Further, at least a portion of the microprojections may be detachable from the microprojection array. Detachable microprojection arrays are described in U.S. Patent Application No. 61/745,513, which is incorporated herein by reference.
In one non-limiting embodiment the microprojection array or other delivery device is affixed or attached to the plunger distal end using an adhesive. Suitable adhesives include, but are not limited to, acrylic adhesives, acrylate adhesives, pressure sensitive adhesives, double-sided adhesive tape, double sided adhesive coated nonwoven or porous film, and UV curable adhesives. It will be appreciated that any medical device adhesive known in the art would be suitable. In another embodiment, at least a portion of the microstructure array or other delivery device is integral with at least a portion of the plunger distal end.
The sizes of the microneedles and other protrusions for use with this invention will be a function of the manufacturing technology and of the precise application. In general, however, microneedles and other microprotrusions used in practice may be expected to have a length of about 20 to about 1000 microns, more preferably from about 50 to about 750 microns and most preferably from about 100 to about 500 microns. Often it will be desired that the microprotrusions will be long enough to penetrate at least partially through the stratum corneum layer of skin at some suitable point of application on the human body, for example the thigh, hip, arm, or torso.
The plate member, plunger, and blocking member may be formed of any suitable material. In one non-limiting embodiment, the plate member and plunger are at least partially formed of a material having an elastic modulus of between about 0.5-500 KSI. In an embodiment, at least one of the plate member or the plunger is formed of a metal including, but not limited to stainless steel, carbon steel, titanium, and alloys thereof. In one preferred embodiment at least the plate member and the plunger are formed of a metal.
The applicator further includes at least one energy-storing element 20 positioned at least partially between a lower surface of the plate member and the distal end of the plunger. Preferably, the energy storing element(s) are retained and/or supported between the plate and the plunger distal end.
Any suitable energy storing element is contemplated including, but not limited to springs or elastic components. In non-limiting embodiments, the energy storing element is an elastic storage element, a compression spring, a coil spring, or a wave spring device. When the plunger is retained by the blocking member, the energy-storage member is restrained in a high energy position of stored energy, and when the plunger is released from the blocking member, the energy-storage member releases its stored energy and in so doing moves the plunger. The energy storing element is typically maintained in a constrained or restrained position between the proximal surface of the plunger and the distal surface of the plate member when the plunger proximal end is retained by the blocking member. When the plunger proximal end is released from the blocking member, the energy storing element is released from the constrained position and the stored energy pushes the plunger distal end away from the plate and toward the patient's skin. The amount of energy stored by the energy storing element may be adjusted based on the application area and/or microstructure structural features. The amount of stored energy may be, for example, in the range of about 0.1 J to about 10 J, or in the range of about 0.25 J to about 1 J. In an embodiment, the energy storing member is selected to provide a force on the plunger sufficient to cause the plunger to travel a distance longer than the length of the plunger shaft. In other embodiments including a housing discussed below, the energy storing member is selected to provide a force on the plunger sufficient to cause the plunger to travel a sufficient distance so that at least a portion of the plunger distal end exits the housing distal end.
A skilled artisan will appreciate the wide variety of energy-storage members that would be suitable for use, and some examples are illustrated in U.S. Patent Publication No. 2011/0276027, which is incorporated herein by reference in its entirety. It is to be understood that other similar shapes, including but not limited to other axisymmetric shapes, may be used to create an energy-storage member. Further, non-symmetric shapes may be used to create an energy-storage member. It is also to be understood that the energy-storage member may comprise a plurality of individual energy-storage members that may or may not be identical in size, shape, and material. The use of a plurality of individual energy-storage members may be useful to allow alteration of plunger velocity, energy, activation force, or other performance characteristics in ways that may not be achievable or different than with a single energy-storage member.
The material from which the energy storage member is manufactured is variable, and a skilled artisan will appreciate that it is selected based on the several design considerations, including storage life and desired application force, which of course will also depend on the configuration of the member. Exemplary materials include metals, alloys, plastics, and specific examples include stainless steel and thermoplastics.
The velocity of the microprojection array or other delivery device at the time of contact with skin may be adjusted, for example, by varying the amount of stored energy in the energy-storing element and/or by changing the mass of the plunger. This is done, for example, by controlling the energy-storing element's geometric design and the properties of the material(s) out of which the energy-storing element is made. The energy-storing element may have a compressed form in which the degree of compression (e.g., in one spatial direction) controls the amount of energy stored.
When the energy storing element is stored in compressed form, a variety of mechanisms external to the element, but forming part of the applicator, may be employed to release the compression and allow the element to uncompress and therefore release some or all of its energy.
The velocity of the microprojection array or other delivery device at the time of contact with the skin may lie, for example, within the range of 0.1 m/s to 20 m/s, or within the range of 0.5 m/s to 10 m/s. In general, the stored energy may be employed in moving the microprojection array or other delivery device into contact with the skin as well as in overcoming any forces (e.g., from other components of the applicator) acting on the microprojection array or other delivery device. In addition, the stored energy may be employed in moving other components which, in accordance with the design of the applicator, must also move as the microprojection array or other delivery device moves towards the skin.
The applicator may further include an outer housing 63 at least partially surrounding or enclosing applicator. In the embodiment shown in
Applicators contemplated herein will commonly have at least two states or configurations. In the first state or configuration, the proximal end of the plunger is retained by the plate member. In the first state or configuration, the energy storing element is restrained between the plate element and the plunger distal end in a high energy position. This is typically expected to be the state of the applicator following manufacturing and during shipping and storage. When the plunger proximal end passes through the at least one opening, the energy storing element is released from the constrained state and releases all or a part of the stored energy. In this second state or configuration, which is arrived at by operating the actuating member or element, the microprojection array or other delivery device projects outward from the applicator.
The materials from which the applicator components are manufactured can be selected from a wide variety known to a skilled artisan. For example, a filled polymer material is suitable for manufacture of at least the outer cover or housing, the blocking member and/or the actuating member. A skilled artisan will understand the various material properties to be considered when selecting a suitable material for each component part.
In another aspect, an applicator for delivery of a needle, microneedle, microprojection, microstructure, arrays thereof, or other delivery device is described herein. The applicator comprises an actuator or actuating member, a plunger or piston, a plate or holder having an opening, and an energy-storing element. The applicator operates by applying a force to the actuating member above a threshold to release the plunger which is retained by the opening of the plate or a flexure element.
In one embodiment, a flexure element 64 having a gap 66 is adjacent the upper or proximal surface 34 of the plate member. The flexure element may be retained at least partially within the opening of the plate member. The flexure element may be retained by or secured to the plate member by any suitable manner including, but not limited to, a mechanical feature such as a locking system, an adhesive, and/or by virtue of the shapes of the opening and the flexure element. The flexure element includes a gap capable of moving between a first position 74 (
The applicator further includes a plunger 16 having a central post or shaft 26 and a proximal 24 and distal end 28. The proximal end of the plunger is preferably sized and shaped so that it is retained by the gap of the flexure element in the first position. It will be appreciated that the plunger may have any suitable shape or size. As shown in
The plate member, plunger, and flexure element may be formed of any suitable material. In one non-limiting embodiment, the plate member and/or flexure element and the plunger are at least partially formed of a material having an elastic modulus of between about 0.5-500 KSI. In embodiment, at least one of the plate member, the plunger, or the flexure element is formed of a metal including, but not limited to stainless steel, carbon steel, titanium, and alloys thereof. In one preferred embodiment, at least the flexure element, where present, and the plunger are formed of a metal.
The distal end of the plunger preferably includes a microprojection or microprojection array or other agent delivery device affixed or integral with a distalmost end or bottom surface 30 of the plunger distal end 28. The discussion of delivery devices above is applicable to this embodiment.
The applicator further comprises an actuating member 68 for moving the gap from the first position to the second position. The actuating member acts to move the gap and/or opening from the first position to the second position. As the gap/opening moves to the second position (or reaches the second position), the gap/opening becomes large or wide enough for the proximal end of the shaft to pass through and be released. Central pressure from the actuating member is preferably evenly distributed to the gap. The actuating member includes a proximal end 70 for receiving pressure and a distal end 72 for positioning at least partially in the gap/opening. The proximal end may have any shape suitable for receiving pressure including without limitation a button, pin, or plate. Typically, the pressure is a downward pressure in the direction from the proximal end of the actuator toward the distal end of the actuator (and typically toward the gap/opening). Pressure may be applied by any suitable means including manual or mechanical. Where the pressure is manually applied, the actuator proximal end has an external surface 78 that is suitable for contact by a user.
The actuator distal end has a shape suitable for moving or pushing the gap/ opening from the first position to the second position. In the embodiment shown in
The polyhedral-shaped member may include a gap, cut-out or area dimensioned to receive or fit around at least a portion of the proximal end of the plunger. In the embodiment shown in
The energy needed to actuate is that required to spread the gap and/or opening sufficiently to allow the plunger proximal end to pass through. This energy depends on their precise dimensions and the material characteristics (e.g., Young's modulus) of the material out of which they are made.
One problem with some prior microstructure arrays is uneven plunger movement during release of the plunger. These effects are undesirable as they lead to tilting or wobbling of the plunger within the housing during application. The plunger loses energy as it contacts or hits the housing, which reduces the energy available for penetrating skin with the microprotrusions. Another issue is that the plunger may tilt in the housing causing the microprotrusions to contact the skin at an angle rather than “straight” with a central axis of the microprotrusions being substantially perpendicular to the skin. With the present configurations, the distal portion of the plunger is released from the gap/opening at a single point of release. These configurations are advantageous because the release of the plunger occurs simultaneously or substantially simultaneously around the undercut or ledge. Thus, the release does not interfere with the direction of deployment of the plunger and the microprotrusion array is deployed in the intended direction with the intended force. The central release conserves energy required to release the plunger, results in consistent energy used to deploy the microstructures into the skin and/or requires lower energy as the microstructures are deployed into the skin at the correct angle.
It will be appreciated that once the plunger proximal end passes through the gap/opening, the gap/opening may return to the first position. In this embodiment, once the plunger proximal end passes through the gap/opening, and the gap/opening has returned to the first position, the proximal end of the plunger may rest against the under or distal surface of the plate and/or flexure element. It will be appreciated that the length of the plunger may be selected or adjusted to provide a desired position when released from the gap/opening. Where the device includes a housing, the length of the plunger may be selected so that a desired length of the plunger extends beyond the housing distal end. In embodiments, it is preferable for the plunger distal end with the microprotrusion array to extend beyond the skin surface at equilibrium. In further embodiments as shown in
As seen in
The present embodiment may further include an outer housing 63 at least partially surrounding or enclosing the applicator. The discussion of a housing above is relevant to and included herein. Preferably at least part of the actuator is accessible or extends beyond the proximal end of the housing so that the user can apply pressure to the actuator. In another embodiment, the housing includes an actuator contacting area or element where the user applies pressure to the housing at the area or to the element that is transferred to the actuator proximal end. In another embodiment, the housing includes an opening at the proximal end for a user to access the actuator. The actuator proximal end may extend at least partially through the opening in the housing or the opening may be dimensioned so that a user may access the proximal end of the actuator through the opening.
As with the above embodiment, applicators contemplated herein will commonly have at least two states or configurations. In the first state or configuration, the proximal end of the plunger is retained by the plate member and/or flexure element. In the first state or configuration, the energy storing element is restrained in a high energy position between the plate element and the plunger distal end. This is typically expected to be the state of the applicator following manufacturing and during shipping and storage. When the plunger proximal end passes through the gap/opening, the energy storing element is released from the constrained state and releases all or a part of the stored energy. In this second state or configuration, which is arrived at by pressing or otherwise operating the actuating element, the microprojection array projects modestly outward from the applicator.
The materials from which the applicator components are manufactured can be selected from a wide variety known to a skilled artisan. For example, a filled polymer material is suitable for manufacture of the outer cover or housing, the flexure member and/or the actuating member. A skilled artisan will understand the various material properties to be considered when selecting a suitable material for each component part.
The applicators described in each of the embodiments described above can optionally include a safety mechanism or latch to prevent unintended actuation of the applicator and consequential deployment of the microneedle array. Various embodiments of a safety mechanism are described in U.S. Patent Publication No. 2011/0276027, which is incorporated herein in its entirety.
A problem with some prior applicators is the plunger is not deployed with sufficient energy or the plunger may bounce after contacting the skin or the skin may move away due to the impact. The skin may thus become separated from the microprotrusion array after the initial impact. Without a retaining force, the skin may separate at the end of the plunger's travel, continuing its motion as the plunger moves at a slower rate. While the microprotrusion array may later return to contact the skin as the plunger bounces, the individual microprotrusions will no longer be aligned with the holes created during the initial impact of the array with the skin and the plunger may not have sufficient energy to create new holes with the microprotrusions. Alternatively, some prior applicators suffer from the excessive application of force or displacement of the plunger. Excessive displacement or impact force of the plunger into the skin can cause uncomfortable sensations and pulling of the skin. Additionally, excessive compression of the skin can reduce fluid flow through the tissues surrounding the microprotrusion array, which slows dissolution of the therapeutic agent from the microprotrusions and the subsequent transport into the subject's system. Both of these problems may lead to the degradation of the drug product and/or improper or incomplete delivery of the therapeutic agent.
The proper contact of the microprotrusions with the skin may be achieved by adjusting the final equilibrium position of the plunger. In embodiments, the displacement of the plunger distal end is 0.03-0.2″ below the surface of the subject's skin at equilibrium. In embodiments, the final displacement of the plunger of at least 0.030″ as measured at plunger equilibrium in free air is desired. The “final displacement” refers to the extension of the plunger distal surface beyond the surface of the skin as shown in
When the microprojections are dissolvable or erodible, a further advantage of an extended plunger equilibrium position is that the continued application of force allows the dissolvable microprojections to penetrate deeper into the skin as the microprojections dissolve. The biased force pressing the microprojections into the skin to the extended equilibrium position may further cause the microprojections to penetrate deeper into the skin as the distal tips dissolve.
Without being limited as to theory, maintaining pressure on the microprotrusions at equilibrium keeps the protrusion distal ends inserted in the skin. As the microprotrusions dissolve, the continued pressure pushes the protrusions deeper into the skin until the protrusions substantially or completely dissolve.
One problem with actuators using an energy storage element such as a spring or elastic element is that the energy storage element may exert forces on one or more components of the applicators, leading to dimensional distortion and/or creep over an extended period of time. These effects are undesirable as they lead to variations in the applicator geometry and a loss in the stored elastic energy over time. In one embodiment, at least the plate and plunger of the blocking element embodiment or the flexure member and the plunger of the opening release embodiment are formed of materials that do not exhibit creep. In one embodiment, at least the plate and plunger or the flexure member and the plunger are formed from a metal. Where the applicator does not include a flexure member, at least the plate member and the plunger may be formed from a metal or material that does not exhibit creep. Exemplary metals include, but are not limited to stainless steel, carbon steel, titanium, and alloys thereof. In this embodiment, all or most of the mechanical load from the energy storage element is borne by metal parts, which are not subject to dimensional distortion and creep over time. In another embodiment, at least the plate and plunger of the blocking element embodiment or the flexure member/plate and the plunger of the opening release embodiment are formed from a plastic or polymer that does not exhibit creep and/or dimensional distortion at a given stress level. In this embodiment, all or most of the mechanical load from the energy storage element is borne by parts formed from materials which are not subject to dimensional distortion and creep over time. Reducing the dimensional distortion and creep leads to maintaining the same stored elastic energy for an extended period of time. Maintaining the same or similar stored elastic energy over a period of time is important for having an extended shelf life of at least preferably about 6 months, more preferably about 12 months, and most preferably about 24 months. In further embodiments, the same stored elastic energy is maintained over a shelf life of at least about 1-10 years. In specific, but not limiting embodiments, the same or similar stored elastic energy is maintained over a shelf life of at least about 1 year, about 2 years, about 3 years, about 4 years, about 5 years, or about 10 years or longer.
Another issue or problem with current microstructure or microneedle arrays arises with extended use or wear of the applicators. Wearing a potentially bulky applicator for an extended period of time is inconvenient during normal activities or exercising. Another potential problem is that the microneedle arrays may bounce off the skin and cause poor drug delivery. Furthermore, another potential problem is the microneedle array may pull out of the skin after impact into the skin also causing poor drug delivery. In some embodiments, it is desirable for the microstructure array or other delivery device to be removable from the applicator. This embodiment provides for a low profile and/or more comfortable delivery device that can be worn for longer or extended periods of time.
In one embodiment, the present applicators may include a backing assembly that is removable from the applicator. In one embodiment as shown in
In one embodiment, the applicators may include a damper to dampen the bounce, upward or vertical motion of the plunger away from a subject. The plunger damper changes the system dynamics from under-damped to critically or over-damped. In non-limiting embodiments, a foam, friction material, or viscous material is placed in mechanical communication with the plunger and the energy storing element to act as a plunger damper. The plunger damper's function is to provide an energy loss to minimize plunger bounce (vertical upward motion) after the applicator is activated and the plunger strikes the skin. In one embodiment as shown in
It will be appreciated that elements and/or embodiments described above with reference to one applicator embodiment are applicable to all applicator embodiments described. Discussion of common elements between the embodiments is intended to apply to all embodiments. In particular, but without limitation, discussion of the plate, actuating member, plunger, delivery devices, energy-storage element, and housing with reference to one embodiment is intended to also apply to other embodiments.
In another aspect, a method for administering an active agent or therapeutic agent to a subject is provided. Preferably, the active or therapeutic agent is administered dermally, transdermally, mucosally, and/or transmucosally. The method comprises providing a microprojection array or other delivery device in conjunction with any one of the applicators described herein, the microprojection array or delivery device comprising at least one active agent. Preferably, the microprojection array or other delivery device is configured to deliver at least one therapeutic agent. The agent may be coated on at least a portion of the microprojections and/or contained within at least a portion of the microstructures. The agent is delivered dermally, transdermally, mucosally, or transmucosally by actuation of the applicator, to deploy the microprojection array into contact with the skin, or more generally a membrane or body surface, of a subject. The active agent to be administered can be one or more of any of the active agents known in the art, and include the broad classes of compounds such as, by way of illustration and not limitation: analeptic agents; analgesic agents; antiarthritic agents; anticancer agents, including antineoplastic drugs; anticholinergics; anticonvulsants; antidepressants; antidiabetic agents; antidiarrheals; antihelminthics; antihistamines; antihyperlipidemic agents; antihypertensive agents; anti-infective agents such as antibiotics, antifungal agents, antiviral agents and bacteriostatic and bactericidal compounds; antiinflammatory agents; antimigraine preparations; antinauseants; antiparkinsonism drugs; antipruritics; antipsychotics; antipyretics; antispasmodics; antitubercular agents; antiulcer agents; anxiolytics; appetite suppressants; attention deficit disorder and attention deficit hyperactivity disorder drugs; cardiovascular preparations including calcium channel blockers, antianginal agents, central nervous system agents, beta-blockers and antiarrhythmic agents; caustic agents; central nervous system stimulants; cough and cold preparations, including decongestants; cytokines; diuretics; genetic materials; herbal remedies; hormonolytics; hypnotics; hypoglycemic agents; immunosuppressive agents; keratolytic agents; leukotriene inhibitors; mitotic inhibitors; muscle relaxants; narcotic antagonists; nicotine; nutritional agents, such as vitamins, essential amino acids and fatty acids; ophthalmic drugs such as antiglaucoma agents; pain relieving agents such as anesthetic agents; parasympatholytics; peptide drugs; proteolytic enzymes; psychostimulants; respiratory drugs, including antiasthmatic agents; sedatives; steroids, including progestogens, estrogens, corticosteroids, androgens and anabolic agents; smoking cessation agents; sympathomimetics; tissue-healing enhancing agents; tranquilizers; vasodilators including general coronary, peripheral and cerebral; vessicants; and combinations thereof. In embodiments the therapeutic agent is a protein or a peptide. In another embodiment, the agent is a vaccine.
Non-limiting examples of peptides and proteins which may be used with microprotrusion arrays include, but are not limited to parathyroid hormone (PTH), oxytocin, vasopressin, adrenocorticotropic hormone (ACTH), epidermal growth factor (EGF), prolactin, luteinizing hormone, follicle stimulating hormone, luliberin or luteinizing hormone releasing hormone (LHRH), insulin, somatostatin, glucagon, interferon, gastrin, tetragastrin, pentagastrin, urogastrone, secretin, calcitonin, enkephalins, endorphins, kyotorphin, taftsin, thymopoietin, thymosin, thymostimulin, thymic humoral factor, serum thymic factor, tumor necrosis factor, colony stimulating factors, motilin, bombesin, dinorphin, neurotensin, cerulein, bradykinin, urokinase, kallikrein, substance P analogues and antagonists, angiotensin II, nerve growth factor, blood coagulation factors VII and IX, lysozyme chloride, renin, bradykinin, tyrocidin, gramicidines, growth hormones, melanocyte stimulating hormone, thyroid hormone releasing hormone, thyroid stimulating hormone, pancreozymin, cholecystokinin, human placental lactogen, human chorionic gonadotropin, protein synthesis stimulating peptide, gastric inhibitory peptide, vasoactive intestinal peptide, platelet derived growth factor, growth hormone releasing factor, bone morphogenic protein, and synthetic analogues and modifications and pharmacologically active fragments thereof. Peptidyl drugs also include synthetic analogs of LHRH, e.g., buserelin, deslorelin, fertirelin, goserelin, histrelin, leuprolide (leuprorelin), lutrelin, nafarelin, tryptorelin, and pharmacologically active salts thereof. Administration of oligonucleotides is also contemplated, and includes DNA and RNA, other naturally occurring oligonucleotides, unnatural oligonucleotides, and any combinations and/or fragments thereof. Therapeutic antibodies include Orthoclone OKT3 (muromonab CD3), ReoPro (abciximab), Rituxan (rituximab), Zenapax (daclizumab), Remicade (infliximab), Simulect (basiliximab), Synagis (palivizumab), Herceptin (trastuzumab), Mylotarg (gemtuzumab ozogamicin), CroFab, DigiFab, Campath (alemtuzumab), and Zevalin (ibritumomab tiuxetan).
In other embodiments, at least a portion of the distal layer comprises an agent suitable for use as a prophylactic and/or therapeutic vaccine. In an embodiment, the vaccine comprises an antigen epitope conjugated on or to a carrier protein. It will be appreciated that vaccines may be formulated with our without an adjuvant. Suitable vaccines include, but are not limited to, vaccines for use against anthrax, diphtheria/tetanus/pertussis, hepatitis A, hepatitis B, Haemophilus influenzae type b, human papillomavirus, influenza, Japanese encephalitis, measles/mumps/rubella, meningococcal diseases (e.g., meningococcal polysaccharide vaccine and meningococcal conjugate vaccine), pneumococcal diseases (e.g., pneumococcal polysaccharide vaccine and meningococcal conjugate vaccine), polio, rabies, rotavirus, shingles, smallpox, tetanus/diphtheria, tetanus/diphtheria/pertussis, typhoid, varicella, and yellow fever.
In another embodiment, at least a portion of the distal layer comprises an agent suitable for veterinary uses. Such uses include, but are not limited to, therapeutic and diagnostic veterinary uses.
In operation, and with reference again to
The following examples are illustrative in nature and are in no way intended to be limiting.
An applicator comprising a microstructure array is applied to a subject's skin. The applicator includes a blocking member that retains a plunger proximal end by being at least partially inserted into a cut-out in the plunger proximal end. The actuator is moved in a pressed down such that the angular slopes of the attached polyhedral-shaped member press with opposing forces on the flexure element increasing the width of a gap in the flexure member. The actuator is moved into contact with the blocking member to rotate the blocking member away from contact with the plunger proximal end until the plunger cut-out clears the blocking member and the plunger is released. The plunger is moved toward the subject's skin by expansion of a spring placed between a plate and the plunger distal end. The plunger impacts the skin and the microstructure array pierces or ruptures the skin surface.
An applicator comprising a microstructure array is applied to a subject's skin. The actuator is pressed down such that the angular slopes of the attached polyhedral-shaped member press with opposing forces on the flexure element increasing the width of a gap in the flexure member. The actuator is pressed until the gap width increases until the undercut of a plunger central post rests clears the flexure element gap and the plunger is released. The plunger is moved toward the subject's skin by expansion of a spring placed between the flexure element and the plunger distal end. The plunger impacts the skin and the microstructure array pierces or ruptures the skin surface.
While a number of exemplary aspects and embodiments have been discussed above, those of skill in the art will recognize certain modifications, permutations, additions and sub-combinations thereof. It is therefore intended that the following appended claims and claims hereafter introduced are interpreted to include all such modifications, permutations, additions and sub-combinations as are within their true spirit and scope.
All patents, patent applications, and publications mentioned herein are hereby incorporated by reference in their entireties. However, where a patent, patent application, or publication containing express definitions is incorporated by reference, those express definitions should be understood to apply to the incorporated patent, patent application, or publication in which they are found, and not necessarily to the text of this application, in particular the claims of this application, in which instance, the definitions provided herein are meant to supersede.
a rigid plate member with an upper surface and a lower surface, the plate member having at least one opening;
a blocking element in contact with the upper surface of the plate member and being capable of moving between a first position and a second position;
a plunger having a proximal end, a distal end on which at least one microprojection can be retained, and a shaft extending therebetween, the proximal end being at least partially retained by the blocking element in its first position;
an energy-storing element positioned between the lower surface of the plate member and the distal end of the plunger; and
an actuating member having an external surface for application of a force, and having at least one surface in mechanical communication with the blocking element, wherein the actuating member moves the blocking element from its first position to its second position when a force is applied to the external surface of the actuating member, thereby to effect release of the energy-storing element.
at least one microprojection positioned on a bottom surface of the plunger distal end.
at least one flexure element in mechanical communication with the blocking element, wherein the flexure element directs the blocking element into the plunger in the blocking member's first position.
the backing member being detachable from the plunger distal end.
a damper positioned between the energy-storing element and a proximal surface of the plunger distal end.
applying to a skin site of the subject, a microprojection array affixed to the distal end of the plunger of the applicator according to the combined or separate embodiments 1-28;
contacting the external surface of the actuating member to actuate the actuating member from a first position to a second position in mechanical communication with the blocking element;
moving the blocking element from its first position in contact with the proximal end of the plunger to its second position, whereby the plunger is released from contact with the blocking member;
releasing the energy-storing element thereby to deploy the plunger into contact with a subject's skin; and
delivering the therapeutic agent from the microprojection array to the subject.
adhering the applicator to the subject's skin.
a planar plate member with an upper surface and a lower surface, the plate member having at least one opening;
a planar flexure element in contact with the upper surface of the plate member, the flexure element (i) having a gap capable of moving between first and second positions and (ii) being positioned to align the gap with the opening in the plate member;
a plunger slidably disposed within the aligned gap and opening, the plunger having a shaft with a distal end on which at least one microstructure can be retained and a proximal end dimensioned such that the proximal end is retained by the gap in its first position and passes through the gap in its second position;
an energy-storing element positioned between the lower surface of the plate member and the distal end of the plunger; and
an actuating member having an external surface and a polyhedral-shaped member, the polyhedral-shaped member dimensioned to move the gap between its first and second positions when the external surface of the actuating member is contacted with sufficient force to effect release of the energy-storing element.
the backing member being detachable from the plunger distal end.
a damper positioned between the energy-storing element and a proximal surface of the plunger distal end.
applying to a skin site of the subject, a microprojection array affixed to the distal end of the plunger of the applicator according to the combined or separate embodiments 35-58;
contacting the external surface of the actuating member to actuate the actuator from a first position to a second position, whereby the flexure element gap is moved from its first position to its second position and releasing the plunger from a restrained position to a deployed position in contact with the subject's skin; and
delivering the therapeutic agent from the microprojection array to the subject.
adhering the applicator to the subject's skin.
This application is a U.S. Non-Provisional Patent Application which is a Continuation of, and claims the benefit of priority to, U.S. Non-Provisional Patent Application No. 14/201,644, filed Mar. 7, 2014, which claims the benefit of priority to Provisional Patent Application No. 61/778,274, filed Mar. 12, 2013, each of which is hereby incorporated by reference in its entirety.
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| WO 2012153266 | Nov 2012 | WO |
| WO 2013172999 | Nov 2013 | WO |
| WO 2014004301 | Jan 2014 | WO |
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| WO 2014100750 | Jun 2014 | WO |
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| Number | Date | Country | |
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| 20190184148 A1 | Jun 2019 | US |
| Number | Date | Country | |
|---|---|---|---|
| 61778274 | Mar 2013 | US |
| Number | Date | Country | |
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| Parent | 14201644 | Mar 2014 | US |
| Child | 16285044 | US |
