Claims
- 1. An article for use in healing of wounds and repair of tissue defects, the article comprising:
(a) a flexible membrane having an upper and a lower surface, each surface defining a substrate formed of a biologically-acceptable biodegradable material adapted to be resorbed in use, each substrate having thereon means capable of orienting cell growth comprising a microgeometry formed in said substrates, a microgeometry of said upper surface proportioned to a cell morphology of soft tissue cells and a microgeometry of said lower surface proportioned to a cell morphology of bone tissue cells.
- 2. The article as recited in claim 1, in which said microgeometry of each substrate comprises a pattern of grooves and ridges.
- 3. The article as recited in claim 2, in which said ridges comprise posts.
- 4. The article as recited in claim 1, in which said membrane defines a width of between about 200 and about 500 microns.
- 5. The article as recited in claim 3, in which said grooves and ridges upon said upper surface defines a dimension of about 2 to about 10 microns, and those upon said lower surface define a dimension of about 8 to about 25 microns.
- 6. The article as recited in claim 5 in which said biodegradable material is selected from a member of the group consisting of as polylactic acid homopolymers, polyglycollic acid co-polymers, combinations thereof, polylactones, polypeptides, polyvinyl alcohols and natural polymers such as collagen and polysaccharides, collagen, Hench's bioglass, fibrinogen and polyimino-carbonate.
- 7. The article as recited in claim 1, in which a weight of said resorbed material is in a range of one to five grams/cm2.
- 8. The article as recited in claim 3, in which said lower surface includes osteoconductive chemical properties.
- 9. The article as recited in claim 5, in which said lower surface includes osteoconductive chemical properties.
- 10. The article as recited in claim 5, in which said membrane comprises means for suturing into or about a wound or bone defect.
REFERENCE TO RELATED APPLICATIONS
[0001] This case is a continuation-in-part of application Ser. No. 09/500,038, filed Feb. 8, 2000 which is a continuation-in-part of application Ser. No. 08/996,224, filed Dec. 22, 1997 (now abandoned) which is a continuation of application Ser. No. 08/639,712, filed Apr. 29, 1996 (now abandoned) which is a continuation of Ser. No. 08/390,805 filed Feb. 15, 1995 (now abandoned) which is a continuation of Ser. No. 08/146,790, filed Nov. 2, 1993 (now abandoned).
Continuations (3)
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Number |
Date |
Country |
Parent |
08639712 |
Apr 1996 |
US |
Child |
08996224 |
Dec 1997 |
US |
Parent |
08390805 |
Feb 1995 |
US |
Child |
08639712 |
Apr 1996 |
US |
Parent |
08146790 |
Nov 1993 |
US |
Child |
08390805 |
Feb 1995 |
US |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
09500038 |
Feb 2000 |
US |
Child |
10081478 |
Feb 2002 |
US |
Parent |
08996224 |
Dec 1997 |
US |
Child |
09500038 |
Feb 2000 |
US |