MINIATURE DIAGNOSTIC DEVICE FOR SERUM CHOLESTEROL

Information

• Research Project
• 3501343

• ApplicationId

  3501343

• Core Project Number

  R43HL040777

• Full Project Number

  1R43HL040777-01A1

• Serial Number

  40777

• FOA Number

• Sub Project Id

• Project Start Date

  4/1/1989 - 35 years ago

• Project End Date

  9/30/1989 - 35 years ago

• Program Officer Name

• Budget Start Date

  4/1/1989 - 35 years ago

• Budget End Date

  9/30/1989 - 35 years ago

• Fiscal Year

  1989

• Support Year

  1

• Suffix

  A1

• Award Notice Date

  3/31/1989 - 35 years ago

Organizations

• Enzymatics, Inc.

The overall object of this research is to develop a miniature, machine-independent, quantitative diagnostic device for plasma cholesterol, that is suitable for cholesterol determination in the home of the doctor's office. The specific research proposed for Phase 1 deals with combining a previously developed cholesterol- specific analog-to-digital chemical color switch with cholesterol esterase activity, to build a reaction matrix that will act on lipoprotein cholesterol esters as well as free cholesterol in lipoprotein particles. Optimization of the system using the sequential simplex method will also be undertaken. Phase I is intended to demonstrate the feasibility of building the cholesterol diagnostic device, based on the a/d color switch. Subsequent phases will reduce the wet chemistry to a dry format, and produce prototype devices.

IC Name

• Activity

  R43

• Administering IC

  HL

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  837

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  ENZYMATICS, INC.

• Organization Department

• Organization DUNS

• Organization City

  HORSHAM

• Organization State

  PA

• Organization Country

  UNITED STATES

• Organization Zip Code

  19044

• Organization District

  UNITED STATES