Medical ventilator systems have long been used to provide supplemental oxygen support to patients. These ventilators typically comprise a source of pressurized air and oxygen, which is fluidly connected to the patient through a conduit or tubing. The amount of pressure in the gas mixture delivered to the patient may be controlled during ventilation including during inspiration and exhalation.
Patients on a ventilator system are more comfortable when the delivered volume of inspired gas is allowed to be exhaled against the least resistance possible. Generally, resistance is due to the pneumatics of the ventilator, including the tubing, patient interface, exhalation valve, etc., and the respiratory physiology of the patient, including the lungs, bronchiole tubing, etc. Some exhalation modes are designed to open the exhalation valve to the greatest extent possible in order to provide the least amount of resistance to patient exhalation. However, these modes may enable exhalation gases to escape so quickly that the pressure in the patient's lungs falls below a prescribed positive end-expiratory pressure (PEEP). This may endanger the patient by, at best, preventing optimal oxygen exchange, and at worst, allowing alveoli in the lungs to collapse. Alternatively, other exhalation modes are designed to slowly reduce the pressure in the patient tubing to prevent undershoot of the prescribed PEEP, but at the expense of patient comfort.
This disclosure describes systems and methods for controlling pressure and/or flow during exhalation in order to quickly reduce pressure in the circuit without undershooting PEEP. The disclosure describes novel exhalation modes for ventilating a patient.
In part, this disclosure describes a method for controlling exhalation during ventilation of a patient on a ventilator. The method includes:
a) determining a control command for an exhalation valve, wherein the control command targets a pressure at the exhalation valve between a minimum pressure and a steady-state pressure for a period of time;
b) controlling the exhalation valve based on the control command during one or more exhalation cycles;
c) monitoring an end exhalation pressure and a flow undershoot during the one or more exhalation cycles;
d) comparing the end exhalation pressure to a predetermined pressure range;
e) comparing the flow undershoot to a predetermined flow threshold; and
f) based on the comparing, updating the control command in order to maintain a positive-end expiratory pressure (PEEP) at the end of the one or more exhalation cycles.
Yet another aspect of this disclosure describes a ventilator system including:
a) means for determining a control command for an exhalation valve, wherein the control command targets a pressure at the exhalation valve between a minimum pressure and a steady-state pressure for a period of time;
b) means for controlling the exhalation valve based on the control command during one or more exhalation cycles;
c) means for monitoring an end exhalation pressure and a flow undershoot during the one or more exhalation cycles;
d) means for comparing the end exhalation pressure to a predetermined pressure range;
e) means for comparing the flow undershoot to a predetermined flow threshold; and
f) based on the comparing, means for updating the control command in order to maintain a positive-end expiratory pressure (PEEP) at the end of the one or more exhalation cycles.
The disclosure further describes a computer-readable medium having computer-executable instructions for performing a method controlling exhalation during ventilation of a patient on a ventilator. The method includes:
a) determining a control command for an exhalation valve, wherein the control command targets a pressure at the exhalation valve between a minimum pressure and a steady-state pressure for a period of time;
b) repeatedly controlling the exhalation valve based on the control command during one or more exhalation cycles;
c) repeatedly monitoring an end exhalation pressure and a flow undershoot during the one or more exhalation cycles;
d) repeatedly comparing the end exhalation pressure to a predetermined pressure range;
e) repeatedly comparing the flow undershoot to a predetermined flow threshold; and
f) based on the comparing, repeatedly updating the control command in order to maintain a positive-end expiratory pressure (PEEP) at the end of the one or more exhalation cycles.
These and various other features as well as advantages which characterize the systems and methods described herein will be apparent from a reading of the following detailed description and a review of the associated drawings. Additional features are set forth in the description which follows, and in part will be apparent from the description, or may be learned by practice of the technology. The benefits and features of the technology will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the disclosure as claimed.
The following drawing figures, which form a part of this application, are illustrative of embodiments, systems and methods described below and are not meant to limit the scope of the invention in any manner, which scope shall be based on the claims appended hereto.
Although the techniques introduced above and discussed in detail below may be implemented for a variety of medical devices, the present disclosure will discuss the implementation of these techniques in the context of a medical ventilator for use in providing ventilation support to a human patient. The reader will understand that the technology described in the context of a medical ventilator for human patients could be adapted for use with other systems, such as ventilators for non-human patients and general gas transport systems.
Medical ventilators are used to provide a breathing gas to a patient who may otherwise be unable to breathe sufficiently. In modern medical facilities, pressurized air and oxygen sources are often available from wall outlets. Accordingly, ventilators may provide pressure regulating valves (or regulators) for controlling pressure in the ventilator circuit during inhalation and exhalation. For example, the ventilator may be connected to centralized sources of pressurized air and pressurized oxygen and may comprise one or more pressure regulating inspiratory valves for regulating the flow or pressure of gases delivered to the patient during inhalation. The regulating inspiratory valves function to regulate flow so that respiratory gases having a desired concentration of oxygen are supplied to the patient at a desired pressure and rate. Additionally, the ventilator may comprise an exhalation valve, which controls the pressure and rate of gases released from the patient circuit during exhalation (i.e., exhaled gases) and/or inhalation (i.e., in the case of inspiratory pressure overshoot). Ventilators capable of operating independently of external sources of pressurized air are also available.
Patients may require respiratory support for a number of reasons. For example, patients may have healthy lungs, but may be ventilated during an invasive surgery. Alternatively, patients may require respiratory support because they are unable to breathe independently because their lungs are diseased or injured. Diseases affecting the lungs include Chronic Obstructive Pulmonary Disease (COPD), emphysema, pneumonia, lung cancer, pulmonary embolism, etc. In many cases, oxygen exchange may be increased if a minimum, positive pressure of gases (i.e., PEEP) is maintained in the alveoli. Moreover, in some cases, if a minimum amount of pressure is not maintained in the lungs, the alveoli may collapse and become adherent at the end of exhalation and then be torn open during the next inhalation—causing additional damage to the lungs. Accordingly, PEEP is often prescribed for ventilated patients.
As discussed above, ventilated patients are more comfortable when the delivered volume of inspired gases is exhaled against the least resistance possible. Indeed, much of the resistance to exhalation is due to the exhalation valve itself. However, allowing exhaled gases to escape in an unregulated manner may allow the pressure in the patient's lungs to fall below PEEP. As such, embodiments described herein provide for regulating the exhalation valve to quickly release pressure in the patient circuit, which minimizes resistance and increases patient comfort, while at the same time regulating the exhalation valve to prevent PEEP undershoot in the lungs.
Ventilation tubing system 130 (or patient circuit 130) may be a two-limb (shown) or a one-limb circuit for carrying gases to and from the patient 150. In a two-limb embodiment, a fitting, typically referred to as a “wye-fitting” 170, may be provided to couple a patient interface 180 (as shown, an endotracheal tube) to an inspiratory limb 132 and an expiratory limb 134 of the ventilation tubing system 130.
Pneumatic system 102 may be configured in a variety of ways. In the present example, pneumatic system 102 includes an expiratory module 108 coupled with the expiratory limb 134 and an inspiratory module 104 coupled with the inspiratory limb 132. Compressor 106 or other sources) of pressurized gases (e.g., air, oxygen, and/or helium) is coupled with inspiratory module 104 and the expiratory module 108 to provide a gas source for ventilatory support via inspiratory limb 132.
The pneumatic system 102 may include a variety of other components, including mixing modules, valves, sensors, tubing, accumulators, filters, etc. Controller 110 is operatively coupled with pneumatic system 102, signal measurement and acquisition systems, and an operator interface 120 that may enable an operator to interact with the ventilator 100 (e.g., change ventilator settings, select operational modes, view monitored parameters, etc.). Controller 110 may include memory 112, one or more processors 116, storage 114, and/or other components of the type commonly found in command and control computing devices. In the depicted example, operator interface 120 includes a display 122 that may be touch-sensitive and/or voice-activated, enabling the display 122 to serve both as an input and output device.
The memory 112 includes non-transitory, computer-readable storage media that stores software that is executed by the processor 116 and which controls the operation of the ventilator 100. In an embodiment, the memory 112 includes one or more solid-state storage devices such as flash memory chips. In an alternative embodiment, the memory 112 may be mass storage connected to the processor 116 through a mass storage controller (not shown) and a communications bus (not shown). Although the description of computer-readable media contained herein refers to a solid-state storage, it should be appreciated by those skilled in the art that computer-readable storage media can be any available media that can be accessed by the processor 116. That is, computer-readable storage media includes non-transitory, volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage of information such as computer-readable instructions, data structures, program modules or other data. For example, computer-readable storage media includes RAM, ROM, EPROM, EEPROM, flash memory or other solid state memory technology, CD-ROM, DVD, or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to store the desired information and which can be accessed by the computer.
The inspiratory module 104 determines the pressure of gases delivered during inspiration. The expiratory module 108 determines the pressure of gases in the patient circuit during exhalation. In one embodiment, the inspiratory module 104 and the expiratory module 108 determine the pressures during ventilation by controlling valves and/or gas flow within the ventilator 100. According to embodiments, pressure in the patient circuit reaches a maximum toward the end of inhalation (e.g., peak inspiratory pressure). Thereafter, as the patient begins to exhale, pressure is released from patient's lungs via the patient circuit based on a pressure gradient between the patient's lungs and ambient atmospheric pressure (about 0 cm H2O). According to embodiments, pressure in the patient circuit may be regulated during exhalation by controlling the extent to which the exhalation valve opens or closes (i.e., regulating the rate at which gases are released from the system). For example, when the exhalation valve is opened to a greater extent, gases are allowed to escape more quickly from the patient circuit (reducing pressure in the patient circuit more quickly). Alternatively, when the exhalation valve is opened to a lesser extent, gases are allowed to escape less quickly from the patient circuit (reducing pressure in the patient circuit more slowly).
According to embodiments, pressure in the patient circuit may be regulated during the entire period of exhalation, such as the amount of pressure released per second or millisecond of the exhalation time period. According to further embodiments, the inspiratory module 104 and the expiratory module 108 may determine the pressures during ventilation by sending instructions (also known as a control commands) to the controller 110, which regulates the valves to control gas flow into or out of the patient circuit during ventilation.
According to embodiments, the exhalation valve in modern mechanical ventilators acts as a variable flow resistor during exhalation. As such, it can cause an increase in the imposed expiratory resistance placed upon the patient which leads to an increased work-of-breathing. As used herein, the term “work-of-breathing” refers to the effort exerted by the patient to inspire and/or exhale gases. Resistance may be reduced by opening the valve to a greater extent and allowing gases to be released from the patient circuit more quickly. However, as specified above, the exhalation valve is regulated such that pressure in the patient's lungs does not fall below PEEP. Moreover, the exhalation valve is regulated to prevent undesired oscillatory behavior of the pressure and flow in the patient circuit. For example, oscillatory behavior can result from nonlinearities of the pneumatic characteristics of the exhalation valve, high bandwidth of the control command, limitations of the sample rate of the control system, and latency of the real-time control command, etc.
In an effort to decrease resistance while preventing PEEP undershoot, systems and methods described herein utilize an expiratory module 108 that functions based on a time-variant expiratory pressure target during exhalation to ensure a faster exhalation time without allowing an undershoot in the lung pressure. Furthermore, systems and methods described herein utilize art exhalation valve control command based on results from an initialization to attenuate the oscillations in pressure and flow at the exhalation valve based on an individual patient. Moreover, systems and methods herein utilize feedback control to fine-tune the expiratory pressure target in order to achieve and maintain PEEP.
The graph 200 shows the ideal pressure and flow trajectories of the patient during exhalation. As shown, the desired PEEP level 208, 5 cmH2O, is reached at the end of exhalation by the lung pressure trajectory 204, without undershoot. Furthermore, though the exhalation valve pressure trajectory 202 undershoots the desired PEEP level 208 for approximately 1.5 seconds, the exhalation valve pressure trajectory 202 eventually stabilizes at the desired PEEP level 208, in the ideal amount of time to ensure that the lung pressure trajectory 204 does not undershoot PEEP. This ideal time is known as the tau time constant, and can be altered by the ventilator to adjust the lung pressure trajectory 204.
As shown in the graph 200, the pressure trajectories are more aggressive than modern mechanical ventilators. The exhalation valve pressure trajectory 202 initially drops to a reference value of 0 cmH2O, instead of the desired PEEP level 208. By changing the reference pressure, the exhalation time is decreased substantially, as shown by the lung pressure trajectory 204. However, because the exhalation time decreases, the time constant is especially important to monitor so that there is no undershoot of the lung pressure.
Furthermore, the increased time constant also affects the lung flow trajectory 216. In comparison to the lung flow trajectory 206 of the graph 200, the lung flow trajectory 216 achieves stabilization in a far greater amount of time. In some patients, this can translate into greater discomfort and negative oscillations. Thus, the graphs 200 and 210 demonstrate that a more aggressive pressure trajectory can be utilized during exhalation, as long as, certain variables, such as the time constant, are calibrated on a patient-by-patient basis.
In general, this disclosure describes embodiments that utilize the concept of a more aggressive initial pressure reference as part of a modified exhalation valve control command provided to the controller 110. The exhalation valve control command determines the opening of the exhalation valve, and thus, the amount of time needed for gas to be exhaled by the patient 150. More specifically, the modified exhalation valve control command is developed through an initialization period in which several command values may be trained utilizing the more aggressive pressure trajectory discussed above. Next, ventilation is delivered based on the values trained in the initialization period with frequent monitoring of pressure and flow to ensure stability.
As illustrated, method 300 begins at the start of ventilation (operation 302). The ventilator 100 then moves to the initialization operation 304 in which the ventilator 100 determines initial values that are later used for a control command that is sent to the controller 110. Specifically, during the initialization operation 304, the ventilator 100 receives a predetermined clinician-inputted desired PEEP-level. Based on this information, and the individual characteristics of the patient, the ventilator 100 determines the appropriate reference pressure, as discussed above in relation to
During the initialization operation 304, the controller 110 determines minimum and steady-state values (u0 and uss) (706 and 710, respectively, in
The minimum (u0) and steady-state (uss) values 706,710 are illustrated in
Upon determining u0 and uss, the ventilator 100 begins the ventilation delivery operation 306, where ventilation continues over one or more breaths and, during exhalation, the exhalation valve is controlled based on the control command. Specifically, the initial values, u0 and uss, determined from the initialization operation 304 are utilized to develop a modified exhalation valve control command. To determine the exhalation valve control command (u(tk)) during ventilation delivery operation 306, the initial values (uss, u0) are inputted into the following equations:
u(tk)=(uss−u0)*(1−exp(−tk/tau))+u0; where
tau=sum*(sample period)/(uss−u0); and where
sum=sum+uss−u0.
In the above equations, the tau represents the time constant and the sample period is the amount of breath cycles in the initialization operation 304. Upon inputting the known variables after the initialization operation 304, the ventilation delivery operation 306 begins and during each exhalation phase, the exhalation valve is controlled based on the control command signal (u), which remains a function of time (tk).
The ventilator 100 continues to control the exhalation valve based on the above exhalation control command until the end condition detection operation 308 detects an end condition. Examples of end conditions include a change in the mode setting, a change in clinician-inputted values, a disconnection of the ventilator, an alarm setting, an operation failure, an occurrence of apnea, or the like. If an end condition is not detected by operation 308, the ventilator 100 continues to ventilate the patient and control the exhalation valve during exhalation based on the control command. However, if an end condition is detected by operation 308, the ventilator 100 discontinues ventilation and terminates at the end operation 310.
The method 400 begins upon the detection of exhalation at an operation 402. Upon detecting exhalation, the method 400 delivers ventilation based on the control command signal u(tk) that was determined during the initialization operation 304. During each exhalation, the method 400 controls the exhalation valve and monitors the stability and consistency of the pressure and flow from one exhalation to the next. This ensures a smoother exhalation control command, and thus, fewer undesired oscillations experienced by the patient.
For example, upon detecting exhalation at operation 402, the ventilator controls the exhalation valve based on the current values at operation 404. More specifically, the ventilator 100 determines whether the measured end exhalation pressure (“EEP”) of the exhalation valve is within some predetermined range (operation 406). The predetermined range may be any range determined by the controller 110 or a clinician prior to exhalation based on factors varying based on each patient, such as, the size of the lungs, the health status of the patient, health risks associated with the patient, or any other individual factors that may affect ventilation. For example, the range may be determined based on a maximum allowable threshold difference between the EEP and the desired PEEP level. The EEP is determined by pressure sensors positioned in the pneumatic system 102, for example, at the exhalation valve.
Upon comparing the EEP measurements with the predetermined allowable range, the operation 406 determines whether the EEP is at an acceptable level. If the ventilator 100 determines that the EEP falls outside of the predetermined range, the method 400 initiates a PEEP correction operation 408. In general, the PEEP correction operation 408 monitors the pressure trajectory of the exhalation valve, and adjusts the trajectory so that the EEP of the exhalation valve falls within the predetermined range. The determination operation 406 and the PEEP correction operation 408 are discussed in greater detail below in reference to
Additionally, the method 400 monitors the expiratory flow undershoot at an operation 410. At operation 410, the ventilator 100 determines whether the expiratory flow of the exhalation valve is under a predetermined threshold. It is important to note that the predetermined threshold of the expiratory flow undershoot is different than the predetermined range discussed above in relation to the EEP threshold. Also, the predetermined threshold of the expiratory flow undershoot may be any threshold determined by the controller 110 or a clinician prior to exhalation based on the factors discussed above. The expiratory flow is measured by sensors positioned in the pneumatic system 102, for example, at the exhalation valve. From this measurement, the controller 110 can determine the expiratory flow undershoot and then compare this measurement to the predetermined threshold.
If the ventilator 100 determines that the expiratory flow undershoot at the exhalation valve is above the predetermined threshold, the method 400 initiates a tau value correction operation 412. In general, at operation 412, the tau value utilized in the exhalation valve control command (u(tk)), is adjusted so that the expiratory flow undershoot is regulated under the predetermined threshold. Thus, the operation 412 adjusts the control command that is sent to the controller 110 which alters the positioning of the exhalation valve. The determination operation 410 and the tau value correction operation 412 is discussed in greater detail in relation to
If, on the other hand, the ventilator 100 determines that the expiratory flow undershoot at the exhalation valve is under the predetermined threshold, the ventilator 100 continues to control the exhalation valve based on any updated values that may have been corrected during either the PEEP correction operation 408 or the tau value correction operation 412. If no values were adjusted, the operation 414 continues to control the exhalation valve based on values from the previous breath cycle until the end of the current exhalation. Upon beginning the subsequent exhalation, the method 400 begins again at operation 402.
As illustrated, the method 500 begins at the start of exhalation (operation 502). The method 500 then enters an average EEP calculation operation 504. During the operation 504, the ventilator 100 calculates an average EEP based on a predetermined number of previous exhalations. For example, the calculation could be based on the past ten exhalations. In other embodiments, the predetermined number of previous exhalations could be any number deemed appropriate by a clinician or determined by the controller 110. For example, the calculation could be programmed so that initial calculation of the average EEP are based on fewer cycles of exhalation whereas later calculations of the average EEP are based on greater cycles of exhalation. The exact EEP measurements of each exhalation are measured by pressure sensors positioned on or around the exhalation valve and stored in the memory 112. At operation 504, the ventilator 100 utilizes the measurements stored in the memory 112 for a previous number of prior exhalations to determine the average EEP.
Upon determining the average EEP for the current exhalation, the method 500 determines how close the average EEP is to the clinician-inputted PEEP level at operation 506. This reference value is discussed in greater detail above in relation to the initialization operation 304 in
If the operation 506 determines that the average EEP does not fall within the predetermined threshold, the method 500 moves to a peep correction operation 508. The peep correction operation 508 utilizes the following equation:
peepCorrection=peepCorrection+0.75*(PEEP−AverageEEP).
In the equation, PEEP is the clinician-inputted PEEP level, AverageEEP is the average EEP that is determined in the operation 504, and peepCorrection is the correction, if any, that was made in the previous exhalation cycle. If no correction was made in the previous exhalation cycle, peepCorrection=0.
After determining the peepCorrection value in operation 508, the method 500 moves to operation 510 in which the peepCorrection value is utilized to alter the control command signal that is sent to the controller 110 to alter the position of the exhalation valve. Specifically, the operation 508 utilizes the following equation to alter the control command (u(tk)):
u(kk)=u(tk)PREVIOUS+peepCorrection.
In this equation, as illustrated, u(tk)PREVIOUS is the control command that was utilized in the previous exhalation cycle.
Upon altering the control command (u(tk)), the method 500 terminates at an end operation 512. The method 500 is called again to monitor the average EEP of the exhalation valve at the start of the next exhalation cycle.
As illustrated, the method 600 begins at an initial point 602. The method 600 then enters an expiratory flow undershoot operation 604. At operation 604, the ventilator 100 measures the expiratory flow of the exhalation valve through flow sensors positioned on or around the exhalation valve. Based on these measurements, the ventilator 100 determines whether there is an undershoot in the expiratory flow and, if so, the amount of undershoot present.
Upon determining the undershoot, the method 600 moves to an operation 606 where the ventilator 100 compares the measured undershoot from operation 604 to a predetermined threshold. For example, in some embodiments, the predetermined threshold may be 0.2 L/min. However, in other embodiments, the predetermined threshold may vary based on the factors that differ for individual patients, discussed above. If it is determined that the measured undershoot falls below the predetermined threshold, the method 600 will terminate at an end operation 612. However, if the measured undershoot falls above the predetermined undershoot flow threshold, the method 600 moves to a tau correction operation 608.
In an embodiment, the tau correction operation 608 updates the time constant, tau, by a fixed amount, in this case a reduction of 10%, utilizing the following equation:
tau=tau*0.9.
In the equation, tau is the value of tau from the previous exhalation cycle. In an alternative embodiment, the time constant may be adjusted based on the amount of undershoot detected, such as by a proportional amount based on the relative difference between the measured undershoot and the threshold. Other factors could also be used to determine the amount to adjust the undershoot including measured EEP, PEEP, and/or patient characteristics.
Based on the tau correction operation 608, the new tau value is then utilized to update the control command signal that is sent to the controller 110. This occurs in an operation 610. The updated tau value is inputted into the original control command equation, as discussed in relation to
u(tk)=(uss−u0)*(1−exp(−tk/tau))+u0.
In the equation, the updated tau value is inputted into the control command equation which is sent to the controller 110. Based on this new control command, the opening of the exhalation valve is adjusted so that the expiratory flow undershoot falls within the appropriate threshold. Upon updating the control command, the method 600 terminates at the end operation 612.
Those skilled in the art will recognize that the methods and systems of the present disclosure may be implemented in many manners and as such are not to be limited by the foregoing exemplary embodiments and examples. In other words, functional elements being performed by a single or multiple components, in various combinations of hardware and software or firmware, and individual functions, can be distributed among software applications at either the client or server level or both. In this regard, any number of the features of the different embodiments described herein may be combined into single or multiple embodiments, and alternate embodiments having fewer than or more than all of the features herein described are possible. Functionality may also be, in whole or in part, distributed among multiple components, in manners now known or to become known. Thus, myriad software/hardware/firmware combinations are possible in achieving the functions, features, interfaces and preferences described herein. Moreover, the scope of the present disclosure covers conventionally known manners for carrying out the described features and functions and interfaces, and those variations and modifications that may be made to the hardware or software or firmware components described herein as would be understood by those skilled in the art now and hereafter.
Numerous other changes may be made which will readily suggest themselves to those skilled in the art and which are encompassed in the spirit of the disclosure and as defined in the appended claims. While various embodiments have been described for purposes of this disclosure, various changes and modifications may be made which are well within the scope of the present invention. Numerous other changes may be made which will readily suggest themselves to those skilled in the art and which are encompassed in the spirit of the disclosure and as defined in the appended claims.
Number | Name | Date | Kind |
---|---|---|---|
3444857 | Godel | May 1969 | A |
3481333 | Garrison | Dec 1969 | A |
3485243 | Bird et al. | Dec 1969 | A |
3688794 | Bird et al. | Sep 1972 | A |
4241756 | Bennett et al. | Dec 1980 | A |
4527557 | DeVries et al. | Jul 1985 | A |
4608976 | Suchy | Sep 1986 | A |
4699137 | Schroeder | Oct 1987 | A |
RE32553 | Bennett et al. | Dec 1987 | E |
4712580 | Gilman et al. | Dec 1987 | A |
4727871 | Smargiassi et al. | Mar 1988 | A |
4752089 | Carter | Jun 1988 | A |
4921642 | LaTorraca | May 1990 | A |
4954799 | Kumar | Sep 1990 | A |
4957107 | Sipin | Sep 1990 | A |
4991576 | Henkin et al. | Feb 1991 | A |
4993269 | Guillaume et al. | Feb 1991 | A |
5000173 | Zalkin et al. | Mar 1991 | A |
5020532 | Mahoney et al. | Jun 1991 | A |
5057822 | Hoffman | Oct 1991 | A |
5072729 | DeVries | Dec 1991 | A |
5072737 | Goulding | Dec 1991 | A |
5109838 | Elam | May 1992 | A |
5127400 | DeVries et al. | Jul 1992 | A |
5134995 | Gruenke et al. | Aug 1992 | A |
5150291 | Cummings et al. | Sep 1992 | A |
5161525 | Kimm et al. | Nov 1992 | A |
5168868 | Hicks | Dec 1992 | A |
5178155 | Mault | Jan 1993 | A |
5237987 | Anderson et al. | Aug 1993 | A |
5255675 | Kolobow | Oct 1993 | A |
5259373 | Gruenke et al. | Nov 1993 | A |
5269293 | Loser et al. | Dec 1993 | A |
5271389 | Isaza et al. | Dec 1993 | A |
5277175 | Riggs et al. | Jan 1994 | A |
5279549 | Ranford | Jan 1994 | A |
5299568 | Forare et al. | Apr 1994 | A |
5301667 | McGrail et al. | Apr 1994 | A |
5301921 | Kumar | Apr 1994 | A |
5303699 | Bonassa et al. | Apr 1994 | A |
5309901 | Beaussant | May 1994 | A |
5319540 | Isaza et al. | Jun 1994 | A |
5325861 | Goulding | Jul 1994 | A |
5331995 | Westfall et al. | Jul 1994 | A |
5333606 | Schneider et al. | Aug 1994 | A |
5339807 | Carter | Aug 1994 | A |
5343857 | Schneider et al. | Sep 1994 | A |
5343858 | Winefordner et al. | Sep 1994 | A |
5351522 | Lura | Oct 1994 | A |
5357946 | Kee et al. | Oct 1994 | A |
5368019 | LaTorraca | Nov 1994 | A |
5368021 | Beard et al. | Nov 1994 | A |
5383449 | Forare et al. | Jan 1995 | A |
5385142 | Brady et al. | Jan 1995 | A |
5390666 | Kimm et al. | Feb 1995 | A |
5398677 | Smith | Mar 1995 | A |
5401135 | Stoen et al. | Mar 1995 | A |
5402796 | Packer et al. | Apr 1995 | A |
5407174 | Kumar | Apr 1995 | A |
5413110 | Cummings et al. | May 1995 | A |
5438980 | Phillips | Aug 1995 | A |
5443075 | Holscher | Aug 1995 | A |
5452714 | Anderson et al. | Sep 1995 | A |
5467766 | Ansite et al. | Nov 1995 | A |
5484270 | Adahan | Jan 1996 | A |
5494028 | DeVries et al. | Feb 1996 | A |
5497767 | Olsson et al. | Mar 1996 | A |
5503140 | Winefordner et al. | Apr 1996 | A |
5513631 | McWilliams | May 1996 | A |
5517983 | Deighan et al. | May 1996 | A |
5520071 | Jones | May 1996 | A |
5524615 | Power | Jun 1996 | A |
5531221 | Power | Jul 1996 | A |
5540220 | Gropper et al. | Jul 1996 | A |
5542415 | Brady | Aug 1996 | A |
5542416 | Chalvignac | Aug 1996 | A |
5544674 | Kelly | Aug 1996 | A |
5546935 | Champeau | Aug 1996 | A |
5549106 | Gruenke et al. | Aug 1996 | A |
5568910 | Koehler et al. | Oct 1996 | A |
5572993 | Kurome et al. | Nov 1996 | A |
5575283 | Sjoestrand | Nov 1996 | A |
5596984 | O'Mahoney et al. | Jan 1997 | A |
5606968 | Mang | Mar 1997 | A |
5617847 | Howe | Apr 1997 | A |
5630411 | Holscher | May 1997 | A |
5632270 | O'Mahony et al. | May 1997 | A |
5645048 | Brodsky et al. | Jul 1997 | A |
5657750 | Colman et al. | Aug 1997 | A |
5660171 | Kimm et al. | Aug 1997 | A |
5662099 | Tobia et al. | Sep 1997 | A |
5664560 | Merrick et al. | Sep 1997 | A |
5664562 | Bourdon | Sep 1997 | A |
5671767 | Kelly | Sep 1997 | A |
5672041 | Ringdahl et al. | Sep 1997 | A |
5673689 | Power | Oct 1997 | A |
5678537 | Bathe et al. | Oct 1997 | A |
5683232 | Adahan | Nov 1997 | A |
5692497 | Schnitzer et al. | Dec 1997 | A |
5697363 | Hart | Dec 1997 | A |
5701883 | Hete et al. | Dec 1997 | A |
5701889 | Danon | Dec 1997 | A |
5715812 | Deighan et al. | Feb 1998 | A |
5762480 | Adahan | Jun 1998 | A |
5771884 | Yarnall et al. | Jun 1998 | A |
5791339 | Winter | Aug 1998 | A |
5794614 | Gruenke et al. | Aug 1998 | A |
5794986 | Gansel et al. | Aug 1998 | A |
5797393 | Kohl | Aug 1998 | A |
5803064 | Phelps et al. | Sep 1998 | A |
5813399 | Isaza et al. | Sep 1998 | A |
5823179 | Grychowski et al. | Oct 1998 | A |
5826575 | Lall | Oct 1998 | A |
5829441 | Kidd et al. | Nov 1998 | A |
5845636 | Gruenke et al. | Dec 1998 | A |
5857458 | Tham et al. | Jan 1999 | A |
5864938 | Gansel et al. | Feb 1999 | A |
5865168 | Isaza | Feb 1999 | A |
5868133 | DeVries et al. | Feb 1999 | A |
5875783 | Kullik | Mar 1999 | A |
5876352 | Weismann | Mar 1999 | A |
5881717 | Isaza | Mar 1999 | A |
5881722 | DeVries et al. | Mar 1999 | A |
5881723 | Wallace et al. | Mar 1999 | A |
5884623 | Winter | Mar 1999 | A |
5909731 | O'Mahony et al. | Jun 1999 | A |
5915379 | Wallace et al. | Jun 1999 | A |
5915380 | Wallace et al. | Jun 1999 | A |
5915382 | Power | Jun 1999 | A |
5918597 | Jones et al. | Jul 1999 | A |
5921238 | Bourdon | Jul 1999 | A |
5934274 | Merrick et al. | Aug 1999 | A |
5937856 | Jonasson et al. | Aug 1999 | A |
5941846 | Duffy et al. | Aug 1999 | A |
5957130 | Krahbichler et al. | Sep 1999 | A |
6024089 | Wallace et al. | Feb 2000 | A |
6041777 | Faithfull et al. | Mar 2000 | A |
6041780 | Richard et al. | Mar 2000 | A |
6047860 | Sanders | Apr 2000 | A |
6073630 | Adahan | Jun 2000 | A |
6076523 | Jones et al. | Jun 2000 | A |
6095139 | Psaros | Aug 2000 | A |
6102038 | DeVries | Aug 2000 | A |
6116240 | Merrick et al. | Sep 2000 | A |
6116464 | Sanders | Sep 2000 | A |
6119686 | Somerson et al. | Sep 2000 | A |
6123073 | Schlawin et al. | Sep 2000 | A |
6123074 | Hete et al. | Sep 2000 | A |
6131571 | Lampotang et al. | Oct 2000 | A |
6135106 | Dirks et al. | Oct 2000 | A |
6135967 | Fiorenza et al. | Oct 2000 | A |
6142150 | O'Mahony | Nov 2000 | A |
6148814 | Clemmer et al. | Nov 2000 | A |
6152132 | Psaros | Nov 2000 | A |
6152135 | DeVries et al. | Nov 2000 | A |
6158432 | Biondi et al. | Dec 2000 | A |
6161539 | Winter | Dec 2000 | A |
6176234 | Salter et al. | Jan 2001 | B1 |
6192885 | Jalde | Feb 2001 | B1 |
6217524 | Orr et al. | Apr 2001 | B1 |
6220245 | Takabayashi et al. | Apr 2001 | B1 |
6269812 | Wallace et al. | Aug 2001 | B1 |
6273444 | Power | Aug 2001 | B1 |
6283119 | Bourdon | Sep 2001 | B1 |
6287264 | Hoffman | Sep 2001 | B1 |
6295330 | Skog et al. | Sep 2001 | B1 |
6295985 | Kock et al. | Oct 2001 | B1 |
6305373 | Wallace et al. | Oct 2001 | B1 |
6306098 | Orr et al. | Oct 2001 | B1 |
6308706 | Lammers et al. | Oct 2001 | B1 |
6309360 | Mault | Oct 2001 | B1 |
6321748 | O'Mahoney | Nov 2001 | B1 |
6325785 | Babkes et al. | Dec 2001 | B1 |
6349922 | Rydin | Feb 2002 | B1 |
6357438 | Hansen | Mar 2002 | B1 |
6360745 | Wallace et al. | Mar 2002 | B1 |
6369838 | Wallace et al. | Apr 2002 | B1 |
6371113 | Tobia et al. | Apr 2002 | B1 |
6412483 | Jones et al. | Jul 2002 | B1 |
6415788 | Clawson et al. | Jul 2002 | B1 |
6419634 | Gaston, IV et al. | Jul 2002 | B1 |
6439229 | Du et al. | Aug 2002 | B1 |
6457472 | Schwartz et al. | Oct 2002 | B1 |
6467478 | Merrick et al. | Oct 2002 | B1 |
6523537 | Mas Marfany | Feb 2003 | B1 |
6523538 | Wikefeldt | Feb 2003 | B1 |
6526970 | DeVries et al. | Mar 2003 | B2 |
6543449 | Woodring et al. | Apr 2003 | B1 |
6546930 | Emerson et al. | Apr 2003 | B1 |
6550479 | Duxbury | Apr 2003 | B1 |
6553991 | Isaza | Apr 2003 | B1 |
6557553 | Borrello | May 2003 | B1 |
6557554 | Sugiura | May 2003 | B1 |
6564798 | Jalde | May 2003 | B1 |
6571795 | Bourdon | Jun 2003 | B2 |
6572561 | Mault | Jun 2003 | B2 |
6575164 | Jaffe et al. | Jun 2003 | B1 |
6575165 | Cook et al. | Jun 2003 | B1 |
6575918 | Kline | Jun 2003 | B2 |
6584973 | Biondi et al. | Jul 2003 | B1 |
6606994 | Clark | Aug 2003 | B1 |
6616615 | Mault | Sep 2003 | B2 |
6619289 | Mashak | Sep 2003 | B1 |
6622725 | Fisher et al. | Sep 2003 | B1 |
6622726 | Du | Sep 2003 | B1 |
6629934 | Mault et al. | Oct 2003 | B2 |
6631716 | Robinson et al. | Oct 2003 | B1 |
6644310 | Delache et al. | Nov 2003 | B1 |
6668824 | Isaza et al. | Dec 2003 | B1 |
6675801 | Wallace et al. | Jan 2004 | B2 |
6718974 | Moberg | Apr 2004 | B1 |
6722359 | Chalvignac | Apr 2004 | B2 |
6723055 | Hoffman | Apr 2004 | B2 |
6725447 | Gilman et al. | Apr 2004 | B1 |
6729331 | Kay | May 2004 | B2 |
6739334 | Valeij | May 2004 | B2 |
6739337 | Isaza | May 2004 | B2 |
6761167 | Nadjafizadeh et al. | Jul 2004 | B1 |
6761168 | Nadjafizadeh et al. | Jul 2004 | B1 |
6763829 | Jaffe et al. | Jul 2004 | B2 |
6772762 | Piesinger | Aug 2004 | B2 |
6805121 | Flood et al. | Oct 2004 | B1 |
6814074 | Nadjafizadeh et al. | Nov 2004 | B1 |
6866040 | Bourdon | Mar 2005 | B1 |
6877511 | DeVries et al. | Apr 2005 | B2 |
6886558 | Tanaka | May 2005 | B2 |
6896713 | Eckerbom et al. | May 2005 | B1 |
6938619 | Hickle | Sep 2005 | B1 |
6960854 | Nadjafizadeh et al. | Nov 2005 | B2 |
6968840 | Smith et al. | Nov 2005 | B2 |
7032589 | Kerechanin, II et al. | Apr 2006 | B2 |
7036504 | Wallace et al. | May 2006 | B2 |
7040315 | Strömberg | May 2006 | B1 |
7040321 | Göbel | May 2006 | B2 |
7043979 | Smith et al. | May 2006 | B2 |
7066175 | Hamilton et al. | Jun 2006 | B2 |
7066177 | Pittaway et al. | Jun 2006 | B2 |
7077131 | Hansen | Jul 2006 | B2 |
RE39225 | Isaza et al. | Aug 2006 | E |
7117438 | Wallace et al. | Oct 2006 | B2 |
7118537 | Baddour | Oct 2006 | B2 |
7121277 | Ström | Oct 2006 | B2 |
7152604 | Hickle et al. | Dec 2006 | B2 |
7168597 | Jones et al. | Jan 2007 | B1 |
7195013 | Lurie | Mar 2007 | B2 |
7210478 | Banner et al. | May 2007 | B2 |
7222623 | DeVries et al. | May 2007 | B2 |
7241269 | McCawley et al. | Jul 2007 | B2 |
7270126 | Wallace et al. | Sep 2007 | B2 |
7275540 | Bolam et al. | Oct 2007 | B2 |
7291115 | Cardona Burrul | Nov 2007 | B2 |
7302949 | Pelerossi et al. | Dec 2007 | B2 |
7320321 | Pranger et al. | Jan 2008 | B2 |
7347825 | Vaughan et al. | Mar 2008 | B2 |
7369757 | Farbarik | May 2008 | B2 |
7370650 | Nadjafizadeh et al. | May 2008 | B2 |
7392806 | Yuen et al. | Jul 2008 | B2 |
7428902 | Du et al. | Sep 2008 | B2 |
7460959 | Jafari | Dec 2008 | B2 |
7475685 | Dietz et al. | Jan 2009 | B2 |
7484508 | Younes | Feb 2009 | B2 |
7487773 | Li | Feb 2009 | B2 |
7487778 | Freitag | Feb 2009 | B2 |
7500483 | Colman et al. | Mar 2009 | B2 |
7509957 | Duquette et al. | Mar 2009 | B2 |
7525663 | Kwok et al. | Apr 2009 | B2 |
7533670 | Freitag et al. | May 2009 | B1 |
7547285 | Kline | Jun 2009 | B2 |
7556038 | Kirby et al. | Jul 2009 | B2 |
7556042 | West et al. | Jul 2009 | B2 |
7562657 | Blanch et al. | Jul 2009 | B2 |
7588033 | Wondka | Sep 2009 | B2 |
7610914 | Bolam et al. | Nov 2009 | B2 |
7617824 | Doyle | Nov 2009 | B2 |
7621271 | Brugnoli | Nov 2009 | B2 |
7634998 | Fenley | Dec 2009 | B1 |
7654802 | Crawford, Jr. et al. | Feb 2010 | B2 |
7694677 | Tang | Apr 2010 | B2 |
7699788 | Kuck et al. | Apr 2010 | B2 |
7717113 | Andrieux | May 2010 | B2 |
7721735 | Hamilton et al. | May 2010 | B2 |
7721736 | Urias et al. | May 2010 | B2 |
D618356 | Ross | Jun 2010 | S |
7740591 | Starr et al. | Jun 2010 | B1 |
7753052 | Tanaka | Jul 2010 | B2 |
7779840 | Acker et al. | Aug 2010 | B2 |
7784461 | Figueiredo et al. | Aug 2010 | B2 |
7810497 | Pittman et al. | Oct 2010 | B2 |
7814908 | Psaros | Oct 2010 | B2 |
7819815 | Younes | Oct 2010 | B2 |
7823588 | Hansen | Nov 2010 | B2 |
7828741 | Kline et al. | Nov 2010 | B2 |
7846739 | von Bahr et al. | Dec 2010 | B2 |
7849854 | DeVries et al. | Dec 2010 | B2 |
7855716 | McCreary et al. | Dec 2010 | B2 |
7861716 | Borrello | Jan 2011 | B2 |
7870857 | Dhuper et al. | Jan 2011 | B2 |
D632796 | Ross et al. | Feb 2011 | S |
D632797 | Ross et al. | Feb 2011 | S |
7883471 | Aljuri et al. | Feb 2011 | B2 |
7885771 | Roecker et al. | Feb 2011 | B2 |
7891354 | Farbarik | Feb 2011 | B2 |
7893560 | Carter | Feb 2011 | B2 |
7900626 | Daly | Mar 2011 | B2 |
7913690 | Fisher et al. | Mar 2011 | B2 |
D638852 | Skidmore et al. | May 2011 | S |
7984714 | Hausmann et al. | Jul 2011 | B2 |
D643535 | Ross et al. | Aug 2011 | S |
7992557 | Nadjafizadeh et al. | Aug 2011 | B2 |
8001967 | Wallace et al. | Aug 2011 | B2 |
D645158 | Sanchez et al. | Sep 2011 | S |
8021310 | Sanborn et al. | Sep 2011 | B2 |
D649157 | Skidmore et al. | Nov 2011 | S |
D652521 | Ross et al. | Jan 2012 | S |
D652936 | Ross et al. | Jan 2012 | S |
D653749 | Winter et al. | Feb 2012 | S |
8113062 | Graboi et al. | Feb 2012 | B2 |
D655405 | Winter et al. | Mar 2012 | S |
D655809 | Winter et al. | Mar 2012 | S |
D656237 | Sanchez et al. | Mar 2012 | S |
8181648 | Perine et al. | May 2012 | B2 |
8210173 | Vandine | Jul 2012 | B2 |
8210174 | Farbarik | Jul 2012 | B2 |
8240684 | Ross et al. | Aug 2012 | B2 |
8267085 | Jafari et al. | Sep 2012 | B2 |
8272379 | Jafari et al. | Sep 2012 | B2 |
8272380 | Jafari et al. | Sep 2012 | B2 |
8302600 | Andrieux et al. | Nov 2012 | B2 |
8302602 | Andrieux et al. | Nov 2012 | B2 |
20020026941 | Biondi et al. | Mar 2002 | A1 |
20020138213 | Mault | Sep 2002 | A1 |
20030062045 | Woodring et al. | Apr 2003 | A1 |
20040138577 | Kline | Jul 2004 | A1 |
20040261793 | Stromberg et al. | Dec 2004 | A1 |
20050039748 | Andrieux | Feb 2005 | A1 |
20050098177 | Haj-Yahya et al. | May 2005 | A1 |
20050139211 | Alston et al. | Jun 2005 | A1 |
20050139212 | Bourdon | Jun 2005 | A1 |
20050150494 | DeVries et al. | Jul 2005 | A1 |
20050217671 | Fisher et al. | Oct 2005 | A1 |
20060032499 | Halsnes | Feb 2006 | A1 |
20060129054 | Orr et al. | Jun 2006 | A1 |
20060130839 | Bassovitch | Jun 2006 | A1 |
20060201507 | Breen | Sep 2006 | A1 |
20060249148 | Younes | Nov 2006 | A1 |
20060249153 | DeVries et al. | Nov 2006 | A1 |
20070000494 | Banner et al. | Jan 2007 | A1 |
20070017515 | Wallace et al. | Jan 2007 | A1 |
20070028921 | Banner et al. | Feb 2007 | A1 |
20070062531 | Fisher et al. | Mar 2007 | A1 |
20070068530 | Pacey | Mar 2007 | A1 |
20070073183 | Kline | Mar 2007 | A1 |
20070077200 | Baker | Apr 2007 | A1 |
20070095347 | Lampotang et al. | May 2007 | A1 |
20070113854 | Mcauliffe | May 2007 | A1 |
20070125377 | Heinonen et al. | Jun 2007 | A1 |
20070144521 | DeVries et al. | Jun 2007 | A1 |
20070144523 | Bolam et al. | Jun 2007 | A1 |
20070157930 | Soliman et al. | Jul 2007 | A1 |
20070157931 | Parker et al. | Jul 2007 | A1 |
20070163579 | Li et al. | Jul 2007 | A1 |
20070227537 | Bemister et al. | Oct 2007 | A1 |
20070232952 | Baddour | Oct 2007 | A1 |
20070255160 | Daly | Nov 2007 | A1 |
20070284361 | Nadjafizadeh et al. | Dec 2007 | A1 |
20080045825 | Melker et al. | Feb 2008 | A1 |
20080053438 | DeVries et al. | Mar 2008 | A1 |
20080053441 | Gottlib et al. | Mar 2008 | A1 |
20080060646 | Isaza | Mar 2008 | A1 |
20080060656 | Isaza | Mar 2008 | A1 |
20080072896 | Setzer et al. | Mar 2008 | A1 |
20080072902 | Setzer et al. | Mar 2008 | A1 |
20080078390 | Milne et al. | Apr 2008 | A1 |
20080083644 | Janbakhsh et al. | Apr 2008 | A1 |
20080092894 | Nicolazzi et al. | Apr 2008 | A1 |
20080097234 | Nicolazzi et al. | Apr 2008 | A1 |
20080135044 | Freitag et al. | Jun 2008 | A1 |
20080183094 | Schonfuss et al. | Jul 2008 | A1 |
20080196720 | Kollmeyer et al. | Aug 2008 | A1 |
20080202517 | Mitton et al. | Aug 2008 | A1 |
20080202518 | Mitton et al. | Aug 2008 | A1 |
20080214947 | Hunt et al. | Sep 2008 | A1 |
20080230062 | Tham | Sep 2008 | A1 |
20080257349 | Hedner et al. | Oct 2008 | A1 |
20080276939 | Tiedje | Nov 2008 | A1 |
20090000621 | Haggblom et al. | Jan 2009 | A1 |
20090007914 | Bateman | Jan 2009 | A1 |
20090050153 | Brunner | Feb 2009 | A1 |
20090056708 | Stenzler et al. | Mar 2009 | A1 |
20090056719 | Newman, Jr. | Mar 2009 | A1 |
20090071478 | Kalfon | Mar 2009 | A1 |
20090078251 | Zucchi et al. | Mar 2009 | A1 |
20090084381 | DeVries et al. | Apr 2009 | A1 |
20090090359 | Daviet et al. | Apr 2009 | A1 |
20090114223 | Bonassa | May 2009 | A1 |
20090133695 | Rao et al. | May 2009 | A1 |
20090137919 | Bar-Lavie et al. | May 2009 | A1 |
20090165795 | Nadjafizadeh et al. | Jul 2009 | A1 |
20090171176 | Andersohn | Jul 2009 | A1 |
20090188502 | Tiedje | Jul 2009 | A1 |
20090205661 | Stephenson et al. | Aug 2009 | A1 |
20090205663 | Vandine et al. | Aug 2009 | A1 |
20090217923 | Boehm et al. | Sep 2009 | A1 |
20090221926 | Younes | Sep 2009 | A1 |
20090229612 | Levi et al. | Sep 2009 | A1 |
20090235935 | Pacey | Sep 2009 | A1 |
20090241948 | Clancy et al. | Oct 2009 | A1 |
20090241951 | Jafari et al. | Oct 2009 | A1 |
20090241952 | Nicolazzi et al. | Oct 2009 | A1 |
20090241953 | Vandine et al. | Oct 2009 | A1 |
20090241955 | Jafari et al. | Oct 2009 | A1 |
20090241956 | Baker, Jr. et al. | Oct 2009 | A1 |
20090241957 | Baker, Jr. | Oct 2009 | A1 |
20090241958 | Baker, Jr. | Oct 2009 | A1 |
20090241962 | Jafari et al. | Oct 2009 | A1 |
20090241964 | Aljuri et al. | Oct 2009 | A1 |
20090247891 | Wood | Oct 2009 | A1 |
20090250054 | Loncar et al. | Oct 2009 | A1 |
20090250059 | Allum et al. | Oct 2009 | A1 |
20090255533 | Freitag et al. | Oct 2009 | A1 |
20090260625 | Wondka | Oct 2009 | A1 |
20090263279 | Kline et al. | Oct 2009 | A1 |
20090270752 | Coifman | Oct 2009 | A1 |
20090277448 | Ahlmén et al. | Nov 2009 | A1 |
20090293877 | Blanch et al. | Dec 2009 | A1 |
20090299430 | Davies et al. | Dec 2009 | A1 |
20090301486 | Masic | Dec 2009 | A1 |
20090301487 | Masic | Dec 2009 | A1 |
20090301490 | Masic | Dec 2009 | A1 |
20090301491 | Masic et al. | Dec 2009 | A1 |
20100011307 | Desfossez et al. | Jan 2010 | A1 |
20100012126 | Gandini | Jan 2010 | A1 |
20100024820 | Bourdon | Feb 2010 | A1 |
20100031961 | Schmidt | Feb 2010 | A1 |
20100051026 | Graboi | Mar 2010 | A1 |
20100051029 | Jafari et al. | Mar 2010 | A1 |
20100059058 | Kuo | Mar 2010 | A1 |
20100069761 | Karst et al. | Mar 2010 | A1 |
20100071689 | Thiessen | Mar 2010 | A1 |
20100071692 | Porges | Mar 2010 | A1 |
20100071695 | Thiessen | Mar 2010 | A1 |
20100071696 | Jafari | Mar 2010 | A1 |
20100071697 | Jafari et al. | Mar 2010 | A1 |
20100078017 | Andrieux et al. | Apr 2010 | A1 |
20100078026 | Andrieux et al. | Apr 2010 | A1 |
20100081119 | Jafari et al. | Apr 2010 | A1 |
20100081955 | Wood, Jr. et al. | Apr 2010 | A1 |
20100099999 | Hemnes et al. | Apr 2010 | A1 |
20100101577 | Kaestle et al. | Apr 2010 | A1 |
20100106037 | Kacmarek et al. | Apr 2010 | A1 |
20100125227 | Bird | May 2010 | A1 |
20100137733 | Wang et al. | Jun 2010 | A1 |
20100139660 | Adahan | Jun 2010 | A1 |
20100147302 | Selvarajan et al. | Jun 2010 | A1 |
20100147303 | Jafari et al. | Jun 2010 | A1 |
20100170512 | Kuypers et al. | Jul 2010 | A1 |
20100175695 | Jamison | Jul 2010 | A1 |
20100179392 | Chang et al. | Jul 2010 | A1 |
20100180897 | Malgouyres | Jul 2010 | A1 |
20100185112 | Van Kesteren et al. | Jul 2010 | A1 |
20100186744 | Andrieux | Jul 2010 | A1 |
20100198095 | Isler | Aug 2010 | A1 |
20100218765 | Jafari et al. | Sep 2010 | A1 |
20100218766 | Milne | Sep 2010 | A1 |
20100218767 | Jafari et al. | Sep 2010 | A1 |
20100222692 | McCawley et al. | Sep 2010 | A1 |
20100236553 | Jafari et al. | Sep 2010 | A1 |
20100236555 | Jafari et al. | Sep 2010 | A1 |
20100241019 | Varga et al. | Sep 2010 | A1 |
20100242961 | Mougel et al. | Sep 2010 | A1 |
20100249584 | Albertelli | Sep 2010 | A1 |
20100252042 | Kapust et al. | Oct 2010 | A1 |
20100268106 | Johnson et al. | Oct 2010 | A1 |
20100268131 | Efthimiou | Oct 2010 | A1 |
20100269834 | Freitag et al. | Oct 2010 | A1 |
20100282258 | Tailor et al. | Nov 2010 | A1 |
20100282259 | Figueiredo et al. | Nov 2010 | A1 |
20100286544 | Tanaka et al. | Nov 2010 | A1 |
20100288283 | Campbell et al. | Nov 2010 | A1 |
20100292601 | Dompeling et al. | Nov 2010 | A1 |
20100300446 | Nicolazzi et al. | Dec 2010 | A1 |
20100324437 | Freeman et al. | Dec 2010 | A1 |
20100324439 | Davenport | Dec 2010 | A1 |
20110004108 | Peyton | Jan 2011 | A1 |
20110009762 | Eichler et al. | Jan 2011 | A1 |
20110011400 | Gentner et al. | Jan 2011 | A1 |
20110023878 | Thiessen | Feb 2011 | A1 |
20110023879 | Vandine et al. | Feb 2011 | A1 |
20110023880 | Thiessen | Feb 2011 | A1 |
20110023881 | Thiessen | Feb 2011 | A1 |
20110029910 | Thiessen | Feb 2011 | A1 |
20110041849 | Chen et al. | Feb 2011 | A1 |
20110041850 | Vandine et al. | Feb 2011 | A1 |
20110066060 | von Bahr et al. | Mar 2011 | A1 |
20110126829 | Carter et al. | Jun 2011 | A1 |
20110126832 | Winter et al. | Jun 2011 | A1 |
20110126834 | Winter et al. | Jun 2011 | A1 |
20110126835 | Winter et al. | Jun 2011 | A1 |
20110126836 | Winter et al. | Jun 2011 | A1 |
20110126837 | Winter et al. | Jun 2011 | A1 |
20110128008 | Carter | Jun 2011 | A1 |
20110132361 | Sanchez | Jun 2011 | A1 |
20110132362 | Sanchez | Jun 2011 | A1 |
20110132364 | Ogilvie et al. | Jun 2011 | A1 |
20110132365 | Patel et al. | Jun 2011 | A1 |
20110132366 | Ogilvie et al. | Jun 2011 | A1 |
20110132367 | Patel | Jun 2011 | A1 |
20110132368 | Sanchez et al. | Jun 2011 | A1 |
20110132369 | Sanchez | Jun 2011 | A1 |
20110132371 | Sanchez et al. | Jun 2011 | A1 |
20110133936 | Sanchez et al. | Jun 2011 | A1 |
20110138308 | Palmer et al. | Jun 2011 | A1 |
20110138309 | Skidmore et al. | Jun 2011 | A1 |
20110138311 | Palmer | Jun 2011 | A1 |
20110138315 | Vandine et al. | Jun 2011 | A1 |
20110138323 | Skidmore et al. | Jun 2011 | A1 |
20110146681 | Jafari et al. | Jun 2011 | A1 |
20110146683 | Jafari et al. | Jun 2011 | A1 |
20110154241 | Skidmore et al. | Jun 2011 | A1 |
20110175728 | Baker, Jr. | Jul 2011 | A1 |
20110196251 | Jourdain et al. | Aug 2011 | A1 |
20110209702 | Vuong et al. | Sep 2011 | A1 |
20110209704 | Jafari et al. | Sep 2011 | A1 |
20110209707 | Terhark | Sep 2011 | A1 |
20110213215 | Doyle et al. | Sep 2011 | A1 |
20110230780 | Sanborn et al. | Sep 2011 | A1 |
20110249006 | Wallace et al. | Oct 2011 | A1 |
20110259330 | Jafari et al. | Oct 2011 | A1 |
20110259332 | Sanchez et al. | Oct 2011 | A1 |
20110259333 | Sanchez et al. | Oct 2011 | A1 |
20110265024 | Leone et al. | Oct 2011 | A1 |
20110271960 | Milne et al. | Nov 2011 | A1 |
20110273299 | Milne et al. | Nov 2011 | A1 |
20120000467 | Milne et al. | Jan 2012 | A1 |
20120000468 | Milne et al. | Jan 2012 | A1 |
20120000469 | Milne et al. | Jan 2012 | A1 |
20120000470 | Milne et al. | Jan 2012 | A1 |
20120029317 | Doyle et al. | Feb 2012 | A1 |
20120030611 | Skidmore | Feb 2012 | A1 |
20120060841 | Crawford, Jr. et al. | Mar 2012 | A1 |
20120071729 | Doyle et al. | Mar 2012 | A1 |
20120090611 | Graboi et al. | Apr 2012 | A1 |
20120096381 | Milne et al. | Apr 2012 | A1 |
20120133519 | Milne et al. | May 2012 | A1 |
20120136222 | Doyle et al. | May 2012 | A1 |
20120137249 | Milne et al. | May 2012 | A1 |
20120137250 | Milne et al. | May 2012 | A1 |
20120167885 | Masic et al. | Jul 2012 | A1 |
20120185792 | Kimm et al. | Jul 2012 | A1 |
20120197578 | Vig et al. | Aug 2012 | A1 |
20120197580 | Vij et al. | Aug 2012 | A1 |
20120211008 | Perine et al. | Aug 2012 | A1 |
20120216809 | Milne et al. | Aug 2012 | A1 |
20120216810 | Jafari et al. | Aug 2012 | A1 |
20120216811 | Kimm et al. | Aug 2012 | A1 |
20120226444 | Milne et al. | Sep 2012 | A1 |
20120247471 | Masic et al. | Oct 2012 | A1 |
20120272960 | Milne | Nov 2012 | A1 |
20120272961 | Masic et al. | Nov 2012 | A1 |
20120272962 | Doyle et al. | Nov 2012 | A1 |
20120304995 | Kauc | Dec 2012 | A1 |
20130000644 | Thiessen | Jan 2013 | A1 |
20130006133 | Doyle et al. | Jan 2013 | A1 |
20130006134 | Doyle et al. | Jan 2013 | A1 |
20130025596 | Jafari et al. | Jan 2013 | A1 |
20130025597 | Doyle et al. | Jan 2013 | A1 |
Number | Date | Country |
---|---|---|
WO 2007102866 | Sep 2007 | WO |
Entry |
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7200 Series Ventilator, Options, and Accessories: Operator's Manual. Nellcor Puritan Bennett, Part No. 22300 A, Sep. 1990, pp. 1-196. |
7200 Ventilatory System: Addendum/Errata. Nellcor Puritan Bennett, Part No. 4-023576-00, Rev. A, Apr. 1988, pp. 1-32. |
800 Operator's and Technical Reference Manual. Series Ventilator System, Nellcor Puritan Bennett, Part No. 4-070088-00, Rev. L, Aug. 2010, pp. 1-476. |
840 Operator's and Technical Reference Manual. Ventilator System, Nellcor Puritan Bennett, Part No. 4-075609-00, Rev. G, Oct. 2006, pp. 1-424. |
DeBlasi, Robert et al., “The Impact of Imposed Expiratory Resistance in Neonatal Mechanical Ventilation: A Laboratory Evaluation”, Respiratory Care, Nov. 2008, vol. 53, No. 11, pp. 1450-1460. |
Number | Date | Country | |
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20130284177 A1 | Oct 2013 | US |