TREA

Mitomycin C derivatives

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Information

  • Patent Grant
  • 4231936
  • Patent Number
    4,231,936
  • Date Filed
    Monday, August 28, 1978
    46 years ago
  • Date Issued
    Tuesday, November 4, 1980
    44 years ago
Information
Abstract
The present invention provides new derivatives of mitomycin C, represented by the formula: ##STR1## wherein R represents a hydroxy group in which case the composition is designated as 7-N-(p-hydroxyphenyl)-mitomycin C or an amino group in which case it is designated as 7-N-(p-aminophenyl)-mitomycin C. The new compounds are produced by reacting mitomycin A with p-aminophenyl or p-phenylenediamine and exhibit good antitumor and antibacterial activities.
Description
Claims
  • 1. A compound of the formula: ##STR6## wherein R is selected from the class consisting of a hydroxy group and an amino group.
  • 2. 7-N-(p-hydroxyphenyl)-mitomycin C.
  • 3. 7-N-(p-aminophenyl)-mitomycin C.
Priority Claims (1)
Number Date Country Kind
52-103542 Aug 1977 JPX
US Referenced Citations (3)
Number Name Date Kind
3332944 Cosulich et al. Jul 1967
3514452 Matsui et al. May 1970
4021449 Fujimoto et al. May 1977
Foreign Referenced Citations (2)
Number Date Country
1071393 Jun 1967 GBX
1110036 Apr 1968 GBX
Non-Patent Literature Citations (1)
Entry
Merck Index, 7th Edition, p. 687 (1960).