Claims
- 1. A device for mixing two or more components, the device comprising:
a first housing for holding a first component; a second housing for holding a second component; a third housing; and a mixing element for reciprocal transfer of at least one of the first and second components between at least two of the first, second, and third housings.
- 2. The device of claim 1 further comprising a removable barrier interposed between at least two of the housings.
- 3. The device of claim 1 wherein said third housing holds a third component.
- 4. The device of claim 1 wherein said second housing is in fluid communication with said first housing.
- 5. The device of claim 1 wherein said second housing is in fluid communication with said third housing.
- 6. The device of claim 1 wherein said first housing is in fluid communication with said third housing.
- 7. The device of claim 1 wherein said mixing element comprises at least one plunger.
- 8. The device of claim 1 wherein said mixing element is selected from the group consisting of a piston, a bladder, a pump, a propeller, and an intraluminal ball or any combination thereof.
- 9. The device of claim 1 wherein at least two of said housings are detachable.
- 10. The device of claim 2 wherein the removable barrier comprises a valve interposed between at least two housings.
- 11. The device of claim 10 wherein said valve comprises a stop-cock.
- 12. The device of claim 1 wherein said mixing element comprises a first plunger joined to the first housing and a second plunger joined to the third housing for reciprocally transferring at least one of the first and second components between the first housing and the third housing through the second housing.
- 13. The device of claim 1 further comprising a slideably mounted member, wherein the slideably mounted member contains a bore, the bore forming the second housing.
- 14. The device of claim 13 wherein the second housing is further divided into a plurality of housings.
- 15. The device of claim 1 wherein a soluble plug divides one or more of the first, second, and third housings.
- 16. The device of claim 1 wherein an insoluble breakable membrane divides one or more of the first, second, and third housings.
- 17. The device of claim 1 wherein one or more housings comprise an obstruction to create turbulent flow to enhance mixing efficiency.
- 18. The device of claim 1 wherein at least two of the housings comprise a syringe.
- 19. The device of claim 2 wherein the removable barrier comprises a soluble plug.
- 20. The device of claim 2 wherein the removable barrier comprises an insoluble breakable membrane.
- 21. A device for preparing a tissue sealant, comprising:
a first chamber comprising a first lumen for holding a first component; a second chamber comprising a second lumen for holding a second component, said second lumen in fluid communication with said first lumen of said first chamber; a third chamber comprising a third lumen, said third lumen in fluid communication with said second lumen of said second chamber; and a transferor for reciprocal transfer of at least one of the first and second components between at least two of the first, second, and third chambers.
- 22. A system for preparing a tissue sealant with a predetermined cure rate, comprising:
a first chamber comprising a lumen; a first mixture, held in the first chamber, comprising an adhesive matrix and a cross-linker; a second chamber detachably fitted to the first chamber; a second component held in the second chamber for adjusting the pH of the first mixture.
- 23. The system of claim 22 wherein the first mixture held in the first chamber is mixed with the second component held in the second chamber to form a second mixture, and wherein the second component adjusts the pH of the second mixture to form a sealant comprising the predetermined cure rate.
- 24. The system of claim 22, wherein the second component held in the second chamber comprises a buffer.
- 25. The buffer of claim 24, wherein the buffer is selected from the group consisting of an ion exchanging resin, organic acids, inorganic acids, acid exchange resins, organic bases, inorganic bases and alkaline exchange resins.
- 26. The buffer of claim 24 wherein the buffer is selected from citric acid, phosphate, succinate, acidic salts, and morpholinoethanesulfonic acid.
- 27. The system of claim 22 wherein the pH of the first mixture is in the range of about 7-13.
- 28. The system of claim 22 wherein the first mixture comprises a carbodiimide crosslinker.
- 29. The system of claim 23 wherein the second component lowers the pH of the second mixture to control the cure rate of the second mixture.
- 30. The system of claim 22 wherein the pH of the first mixture is in the range of about 1-7.
- 31. The system of claim 23 wherein the second component raises the pH of the second mixture to control the cure rate of the second mixture.
- 32. The system of claim 22 wherein the lumen of the second chamber is coated with the second component.
- 33. A method for preparing a tissue sealant with a predetermined cure rate, comprising:
fitting a first chamber holding a first mixture comprising an adhesive matrix and a cross-linker at about pH 7-13 to a second chamber, introducing the first mixture from the first chamber into the second chamber holding a buffer, wherein the buffer adjusts the pH of the first mixture to a predetermined level; and mixing the first mixture and the buffer in the second chamber to form a sealant having a predetermined cure rate.
RELATED APPLICATIONS
[0001] This application claims benefit of U.S. provisional application serial No. 60/375,683 filed on Apr. 26, 2002.
Provisional Applications (1)
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Number |
Date |
Country |
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60375683 |
Apr 2002 |
US |