Modification of Proteins by ADP-ribose

Information

• NSF Award
• 8917274

Owner

• University of North Texas Health Science Center at Fort Worth

• Award Id

  8917274

• Award Effective Date

  2/15/1990 - 34 years ago

• Award Expiration Date

  7/31/1992 - 32 years ago

• Award Amount

  $ 140,000.00

• Award Instrument

  Continuing grant

There is now compelling evidence that the modification of proteins with ADP-ribose is a general feature of endogenous eucaryotice metabolism. The study of this metabolism has been limited due to a lack of analytical methods of sufficient sensitivity and selectivity. The overall objective of this proposal is to achieve an understanding of the chemistry of ADP:protein linkages. The approach is to use ADP-ribosyl amino acids as model systems. These will be synthesized, isolated and characterized and used as references standards for the development of methods which will allow the direct identification of ADP-ribosyl amino acid residues in endogenous proteins. The research will lay the groundwork for understanding endogenous eucaryotic ADP-ribose metabolism and the mode of action of bacterial toxins.

• Program Officer

  Marcia Steinberg

• Min Amd Letter Date

  2/26/1990 - 34 years ago

• Max Amd Letter Date

  2/7/1991 - 34 years ago

• ARRA Amount

• Name

  University of North Texas Health Science Center at Fort Worth

• City

  Fort Worth

• State

  TX

• Country

  United States

• Address

  3500 Camp Bowie Blvd.

• Postal Code

  761072699

• Phone Number

  8177355073

• First Name

  Myron

• Last Name

  Jacobson

• Start Date

  2/15/1990 12:00:00 AM

• First Name

  Elaine

• Last Name

  Jacobson

• Start Date

  2/15/1990 12:00:00 AM

• Name

  Health

• Code

  203000

• Name

  Life Science Biological

• Code

  61

• Text

  MOLECULAR BIOCHEMISTRY

• Code

  1166