Claims
- 1. A biologically active protein composition for oral or local administration, which comprises
- a modified biologically active protein consisting essentially of a biologically active protein covalently bonded to lecithin and a protease inhibitor which does not inhibit said modified biologically active protein.
- 2. The biologically active protein composition according to claim 1, wherein the biologically active protein is an antibody.
- 3. The biologically active protein composition according to claim 1, wherein the biologically active protein is superoxide dismutase.
- 4. The biologically active protein composition according to claim 1, wherein the biologically active protein is insulin.
- 5. The biologically active protein composition according to claim 1, wherein the biologically active protein is callidinogenase.
- 6. The biologically active protein composition according to claim 1, which is represented by the formula (I):
- A(X--B).sub.k (I)
- wherein A is a residue of the biologically active protein, B is a residue of lysolecithin bonded to X by a hydroxyl group at the 2-position of glycerol, with the hydrogen atom of said hydroxyl group removed, X is a covalent linking group, and k is a bond number of at least 1.
- 7. The biologically active protein composition according to claim 6, wherein X is ##STR6## wherein each of R.sup.1 and R.sup.2 is an alkylene group.
- 8. The biologically active protein composition according to claim 6, wherein A is the residue of an antibody.
- 9. The biologically active protein composition according to claim 6, wherein A is the residue of superoxide dismutase.
- 10. The biologically active protein composition according to claim 6, wherein A is the residue of insulin.
- 11. The biologically active protein composition according to claim 6, wherein A is the residue of callidinogenase.
Priority Claims (2)
Number |
Date |
Country |
Kind |
1-174371 |
Jul 1989 |
JPX |
|
1-310056 |
Nov 1989 |
JPX |
|
Parent Case Info
The present application is a divisional of copending application Ser. No. 07/832,585 filed on Feb. 7, 1992, now U.S. Pat. No. 5,310,958, which is a divisional of application Ser. No. 07/547,039 filed Jul. 2, 1990 now U.S. Pat. No. 5,109,118.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5120710 |
Liedtke |
Jun 1992 |
|
Non-Patent Literature Citations (1)
Entry |
Tan, Diss. Abstr. B, 27(12), pp. 4241-4242 (1967). |
Divisions (2)
|
Number |
Date |
Country |
Parent |
832585 |
Feb 1992 |
|
Parent |
547039 |
Jul 1990 |
|