Claims
- 1. Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modifications Gln63.fwdarw.Arg and Trp64.fwdarw.Ala.
- 2. The modified ciliary neurotrophic factor of claim 1, designated RG 242.
- 3. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 2 and a carrier.
- 4. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 1 and a carrier.
- 5. Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modifications Gln63.fwdarw.Arg, Cys17.fwdarw.Ala and a deletion of the C-terminal 13 amino acid residues.
- 6. The modified ciliary neurotrophic factor of claim 5, designated RG 297.
- 7. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 6 and a carrier.
- 8. The modified human ciliary neurotrophic factor of claim 5, having the additional modification Trp64.fwdarw.Ala.
- 9. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 8 and a carrier.
- 10. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 5 and a carrier.
- 11. Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modifications Gln63.fwdarw.Arg and a deletion of the C-terminal 13 amino acid residues.
- 12. The modified ciliary neurotrophic factor of claim 11, designated RG 290.
- 13. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 12 and a carrier.
- 14. A composition comprising a substantially pure modified ciliary neurotrophic factor according to claim 11 and a carrier.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 07/959,284 filed Oct. 9, 1992, now U.S. Pat. No. 5,349,056 issued Sep. 20, 1994.
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
959284 |
Oct 1992 |
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