Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders

REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY

The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Apr. 8, 2021, is named EB2020-02_USreg_Sequence_listing.txt and is 629,761 bytes in size.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. application 63/007,191 filed Apr. 8, 2020, U.S. application 63/132,190 filed Dec. 30, 2020, U.S. application 63/137,998 filed Jan. 15, 2021, and U.S. application 63/137,989 of Jan. 15, 2021, all of which are herein incorporated by reference in their entirety.

TECHNICAL FIELD

The present invention relates to compositions, kits and methods for modifying bacteria, preferably naturally occurring bacteria, in situ.

BACKGROUND OF THE INVENTION

The human microbiota comprises bacteria, archaea, viruses, and microbial eukaryotes living in our bodies. The taxonomic composition of these communities has been extensively studied and is significantly associated with a variety of diseases and traits. This microbiota indeed consists of thousands of different bacterial species that carry hundreds of billions of genes, which is called the microbiome. This microbiome encodes for a variety of molecules (proteins, lipids, sugars, RNA, etc.) and functions that are essential and beneficial for their host, for instance the enrichment of glycans metabolism, amino acids and xenobiotics but also the regulation of our immune system. It is also responsible for the synthesis of vitamins, isoprenoids and other nutrients which results in human overall metabolism representing an amalgamation of microbial and human attributes.

Widespread deployment of sequencing technologies has revealed that most bacterial species harbor extensive genetic variation not only between hosts, but often within a host over time, and even within a host at a given time.

Isolation and sequencing of numerous strains highlight the genetic heterogeneity within a single bacterial species. Between different strains within a single bacterial species, this variation comprises single-nucleotide variants, short insertions and deletions (indels), and larger structural variants, which include duplications, deletions, insertions, inversions but also horizontal gene transfer such as prophage or plasmid acquisition and recombination events with such exogenous DNA.

Due to such variations, such strains, when co-existing in a single host, often compete with each other for their existence in a specific microbiome niche.

Interestingly, there is a growing body of recent studies based on metagenome sequencing that demonstrate that the presence of specific strains (and therefore of specific genetic signatures in the microbiome) can be directly linked to a number of pathologies, including autoimmunity, infections, inflammation, neurodegenerative diseases or tumorigenesis.

To treat microbiome-associated diseases or disorders, current approaches try to remove unwanted bacteria (and therefore the deleterious genes they carry) by using subtractive methods such as antibiotics, replicative phages, lysins, which result in the killing of deleterious bacteria but also non-deleterious bacteria.

While such strategies have proven to be beneficial on the short term by significantly reducing the load of entire bacterial populations, it can both:

- induce a strong dysbiosis and indirectly lead to the short-term overgrowth of non-targeted deleterious bacterial species or strains. For example, bacteria such as Clostridium difficile are known to fill the bacterial void created by antibiotic treatment. Thus, the killing of a particular targeted species or strain of bacteria within the microbiome can create a void that can be filled by harmful bacteria both in the short-term and in the long term. These bacteria can be of the same or a different species as the targeted species.
- lead to the emergence of antimicrobial resistance in the long term and therefore become inefficient in excluding the species or strain(s) carrying the genetic elements associated with the pathology. For example, antibiotic use has been associated with the replacement of antibiotic-sensitive strains of Staphylococcus aureus with antibiotic-resistant strains of Staphylococcus aureus. Therefore, The durable elimination of an engrafted bacterial population in the microbiome can be challenging to achieve, as the microbiome is naturally in a state of equilibrium with different populations (strain or species) occupying different geographic and metabolic niches. A non-specific treatment like an antibiotic typically leads to a return to the equilibrium that existed before treatment after a few weeks or months. On occasion, the equilibrium will be perturbed for longer periods of time and a dysbiosis can occur. A targeted elimination of a population by phage therapy (wild-type phages to engineered phages, packaged phagemids), lysins, antimicrobial peptides, or any other targeted killing approaches can be equally challenging as targeted bacterial survivors will tend to quickly regrow to occupy the niche that was left empty.

The durable elimination of a bacterial population in the microbiome can be challenging to achieve, as the microbiome is naturally in a state of equilibrium with different populations (strain or species) occupying different geographic and metabolic niches. A non-specific treatment like an antibiotic typically leads to a return to the equilibrium that existed before treatment after a few weeks or months. On occasion, the equilibrium will be perturbed for longer periods of time and a dysbiosis can occur. A targeted elimination of a population by phage therapy (wild-type phages to engineered phages, packaged phagemids), lysins, antimicrobial peptides, or any other targeted killing approaches can be equally challenging as targeted bacterial survivors will tend to quickly regrow to occupy the niche that was left empty.

For these reasons, the genetic modification of a target bacterial population in-situ whether at the strain or species level, can be an interesting alternative. It can lead to the modification of a deleterious population to remove its deleterious effect without killing the target bacteria, and in some cases even without affecting its fitness therefore not disturbing the equilibrium of the ecosystem.

In this way, no void would be created that could be filled by harmful bacteria nor would it lead to treatment resistance. Such an approach would represent a very powerful and elegant approach to treat, prevent or cure a number of microbiome-associated diseases or disorders, especially in the case of long term or chronic pathologies. The invention fulfills this need.

BRIEF SUMMARY OF INVENTION

The invention relates to methods, kits and compositions for modifying a naturally occurring bacteria in situ. In one embodiment, the method, in particular the non-therapeutic method, comprises genetically modifying a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence. Preferably, the genetic modification does not lead to the death of bacteria.

In one embodiment, the method, in particular the non-therapeutic method, comprises contacting said naturally occurring bacteria with a vector encoding enzymes or systems for inducing genetic modifications. The invention also concerns a vector encoding enzymes or systems for inducing genetic modifications, for use in a therapeutic method of modifying a naturally occurring bacteria in situ and/or in vivo.

In one embodiment, said vector further comprises a conditional origin of replication which is inactive in the targeted bacteria but is active in a donor bacterial cell. In a particular embodiment, said conditional origin of replication is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof. In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, nucleic acid, RNA, molecule or any combination thereof. In a particular embodiment, said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs). In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase. In a particular embodiment, said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073. In a particular embodiment, said conditional origin of replication comprises or consists of the sequence SEQ ID NO: 7 or SEQ ID NO: 8.

In one embodiment, said vector is devoid of an antibiotic resistance marker.

In one embodiment, said vector is located inside a delivery vehicle that allows the transfer of the vector into bacteria, more particularly inside a bacterial virus particle. In one embodiment, the method comprises contacting said naturally occurring bacteria with a vector located inside a delivery vehicle that allows the transfer of the vector into bacteria. Preferably, the vector located inside a delivery vehicle is a phagemid and, preferably, the delivery vehicle is a bacterial virus particle or a capsid.

In a particular embodiment, said vector is inside a bacterial virus particle, more particularly is in the form of a packaged phagemid. In one embodiment, the method comprises transducing said naturally occurring bacteria with a packaged phagemid. Preferably, the phagemid comprises a nucleic acid sequence encoding a modified nuclease that is modified to be unable to perform DNA double strand break while retaining its DNA binding capacity and that is fused to a domain to perform other types of function, such as for instance a domain to perform base editing. Preferably, the phagemid comprises a nucleic acid sequence encoding a nuclease that is an RNA guided nuclease. Preferably, the phagemid comprises a nucleic acid sequence encoding a dCas9 (dead-Cas9) or nCas9 (nickase Cas9). In one embodiment, the phagemid comprises a nucleic acid sequence encoding a dCas9 and a deaminase domain, or a nCas9 and a deaminase domain.

In one embodiment, the genetic modification is at least one point mutation(s).

In one embodiment, the genetic modification is at least one insertion or at least one deletion.

In one embodiment, the genetic modification is at least one point mutation(s), insertion and/or deletion inside a coding sequence leading to a frameshift mutation.

In one embodiment, the bacteria with the genetic modification does not have a reduced in vivo growth rate and/or fitness as compared to the same bacteria without the genetic modification.

In one embodiment, the genetic modification is in a bacterial toxin gene. In one embodiment, the genetic modification is in the ClbP gene in pks+ E. coli and results in a single amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity. Preferably, the genetic modification is at S95 or K98 of the ClbP gene. More preferably, the genetic modification is selected from the group consisting of S95A, S95R and K98T¹.

In one embodiment, the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene, said beta-galactosidase gene being typically of sequence SEQ ID NO: 2323, and typically encoding a protein of sequence SEQ ID NO: 2322. Preferably, the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein with the genetic modification shows lower homology with human MYH6 cardiac peptide, said human MYH6 cardiac peptide being typically of sequence SEQ ID NO: 2324, as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification².

In one embodiment, the method comprises genetically modifying at least one DNA sequence or gene in the naturally occurring bacteria in situ in a subject, in particular in a human. In one embodiment, the method comprises modulating host-microbiome interaction by genetically modifying naturally occurring bacteria in situ wherein said naturally occurring bacteria is involved in microbiome associated disorder or disease.

In one embodiment, the method comprises genetically modifying a DNA sequence responsible for a microbiome associated disorder or disease in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence. In one embodiment, the genetic modification reduces the effects of the microbiome associated disorder or disease, and the genetic modification does not lead to the death of bacteria. Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In one embodiment, the method is to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the host microbiome. In one embodiment, the method comprises contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population without cleaving the DNA sequence. The invention also concerns a vector generating a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by bacteria in at least some of the bacteria of a bacterial population of a host microbiome without cleaving the DNA sequence, for use to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host, wherein said vector modifies the immunogenic profile of said bacterial population. Preferably, the genetic modification of the DNA sequence coding for the immunogenic component results in loss of the immunogenic effect of said immunogenic component, wherein said genetic modification does not lead to the direct death of the bacteria. Preferably, the genetic modification of the DNA sequence coding for the immunogenic component results in the inability of the immune system to recognize the immunogenic component. Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In one embodiment, the method comprises contacting said naturally occurring bacteria with a vector encoding enzymes or systems for inducing genetic modifications.

In one embodiment, said vector is devoid of an antibiotic resistance marker.

In one other embodiment, said vector comprises an auxotrophic marker.

In one embodiment, said vector is located inside a delivery vehicle that allows the transfer of the vector into bacteria, more particularly inside a bacterial virus particle.

In one embodiment, the method comprises contacting said naturally occurring bacteria with a vector located inside a delivery vehicle that allows the transfer of the vector into bacteria.

Preferably, the delivery vehicle with the vector is a packaged phagemid.

In a particular embodiment, said packaged phagemid comprises a phagemid encoding an enzyme that modifies the genome of said bacterial. Preferably, said enzyme is a base editor or a prime editor.

In one embodiment, the method comprises transducing said bacteria with a packaged phagemid comprising a phagemid encoding an enzyme that modifies the genome of said bacteria. Preferably, the method comprises transducing said bacteria with a packaged phagemid comprising a phagemid encoding an enzyme that is a base editor. Preferably, the method comprises transducing said bacteria with a packaged phagemid comprising a phagemid encoding an enzyme that is a prime editor.

In one embodiment, the modification is at least one point mutation(s) in a protein-encoding nucleic acid sequence that results in a change of amino acid in a mimic peptide and renders the mimic peptide not immunogenic i.e. not recognized by the immune system.

In one other embodiment, the genetic modification results in a change of sugar profile on the bacterial membrane.

In one other embodiment, the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of sugar profile on the bacterial membrane

In one other embodiment, the genetic modification results in a change of lipid profile on the bacterial membrane.

In one other embodiment, the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of lipid profile on the bacterial membrane.

In one embodiment, the genetic modification renders a catalytic site inactive. In one embodiment, the genetic modification renders a binding site with a human cell receptor non-functional.

In one embodiment, the genetic modification is a point mutation(s) that results in a change of amino acid in a mimic peptide and renders the mimic peptide not immunogenic i.e. not recognized by the immune system.

In one embodiment, the genetic modification(s) that result(s) in a change of amino acid on the protein sequence are/is chosen so that a single genetic mutation cannot revert the modified amino acid back to original.

The invention encompasses methods for screening for genetic modifications in bacteria. In one embodiment, the method comprises:

- administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene or DNA sequence of a naturally occurring bacteria without introducing a double strand break in said DNA sequence,
- subsequently collecting a bacterial sample from the subject, and
- quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample.

In one embodiment, the method comprises quantitating the level of bacteria not containing a genetic modification in at least one base of a DNA sequence of interest.

The invention encompasses methods for determining the efficiency of a vector at inducing genetic mutations in situ comprising:

- administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene or DNA sequence of a naturally occurring bacteria without introducing a double strand break in said DNA sequence,
- subsequently collecting a bacterial sample from the subject,
- quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample.

The invention also encompasses a method for modifying a naturally occurring bacteria in situ in a subject, said method comprising:

- collecting a bacterial sample from the microbiome of the subject,
- contacting said bacterial sample with a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene or DNA sequence of a naturally occurring bacteria without introducing a double strand break in said DNA sequence,
- quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample, and determining thereby the efficiency of said vector at inducing genetic mutations in said subject, and
- administering, to said subject, said vector designed to genetically modify at least one base of a DNA sequence of interest in a gene or DNA sequence of a naturally occurring bacteria without introducing a double strand break in said DNA sequence, in particular when said determined efficiency is higher than or equal to a given value.

The invention encompasses methods for determining the effect of a genetic mutation on bacterial growth comprising:

- administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene or DNA sequence of a naturally occurring bacteria, without introducing a double strand break in said DNA sequence,
- subsequently collecting at least two sequential bacterial samples from the subject,
- quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial samples.

In one embodiment, said genetic modification is a genetic modification of the ClbP gene in pks+ E. coli that results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin but maintains the antagonistic activity.

The invention encompasses a bacteriophage, bacterial virus particle or packaged phagemid for modifying in situ a naturally occurring bacteria, said bacteriophage, bacterial virus particle or packaged phagemid comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the genome of said target bacteria without introducing a double strand break in the DNA sequence, but does not lead to the death of the target bacteria. The invention encompasses the use of said bacteriophage, bacterial virus particle or packaged phagemid, wherein the gene editing enzyme/system targets a DNA sequence or gene within the target bacteria encoding a protein which is directly or indirectly responsible for a disease or disorder. The invention encompasses a bacteriophage, bacterial virus particle or packaged phagemid comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the DNA sequence or gene within said target bacteria encoding a protein which is directly or indirectly responsible for a disease or disorder without introducing a double strand break in the DNA sequence, for use for preventing and/or treating said disease or disorder.

Furthermore, a subject's microbiome can affect the metabolism of drug, food supplement, prebiotic or even cosmetic agent, or any compound administered or produced by the host or produced by other bacteria from the host, or affect the interaction of such compounds with the host or action of such compounds on the host. The invention thus also concerns a method to modify in situ interaction of a bacteria from a microbiome of a subject with a compound administered to or produced by said subject or produced by other bacteria from said subject, by modifying at least one bacterial DNA sequence involved in the interaction of said bacteria with said compound, said bacterial DNA sequence being expressed by a bacterial population of the host microbiome, said method comprising:

contacting the bacterial population with a vector that generates a genetic modification in said at least one DNA sequence of the bacteria, involved in the interaction of said bacteria with said compound, in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence;

wherein the genetic modification of said at least one DNA sequence results in a modification of the interaction of the bacteria with said compound; and

wherein the genetic modification does not lead to the direct death of the bacteria.

Said interaction of a bacteria with a compound administered to or produced by the subject or produced by other bacteria from said subject, encompasses (i) modification of said compound by said bacteria and/or (ii) competition between said compound and a molecule produced and/or secreted by said bacteria for a ligand from said subject and/or (iii) binding/adsorption of said compound by said bacteria.

In a particular embodiment, the invention concerns a method to modify the metabolism of a given drug in a host treated with said drug, by modifying at least one drug-targeting enzyme expressed by a bacterial population of the host microbiome, comprising:

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the DNA sequence coding for the drug-targeting enzyme results in a modification of the drug metabolism in the host;

wherein genetic modification does not lead to the direct death of the bacteria.

Said modification of the metabolism of a given drug may be selected from the group consisting of a modification preventing-transformation of a given drug into a toxic compound for the host, a modification preventing hydrolysis of a given drug thus leading to a prolonged activity of said drug, an enzymatic modification of a given drug leading to an increased and/or prolonged activity of said drug, a transformation of said given drug into an active or more active compound, a modification preventing reactivation of detoxified compounds from a given drug.

The invention encompasses compositions and methods to ensure a robust alteration of all targeted bacteria within a microbiome population, thanks to the delivery of a nuclease programmed to discriminate between target bacteria that have been genetically modified in situ and target bacteria in which the modification has not occurred, leading to the specific killing of those in which the modification has not occurred. The present invention thus further concerns a method for ensuring a robust alteration of all targeted bacterial within a microbiome population, said method comprising contacting said microbiome population with a vector comprising a nucleic acid encoding a nuclease programmed to discriminate between targeted bacteria that have been genetically modified in situ and target bacteria in which the modification has not occurred, wherein said programmed nuclease enables the specific killing of targeted bacteria in which the modification has not occurred. In a particular embodiment, the delivery of such nuclease is either on the same DNA payload as the one containing the base-editing nuclease, or on a different payload. In other words, in a particular embodiment, the nucleic acid encoding said programmed nuclease is located on the same vector as the one comprising the nucleic acid encoding the base-editing nuclease or on a different vector. In a particular embodiment, the delivery of such nuclease is either simultaneous with or after the delivery of the payload containing the base-editing. In other words, in a particular embodiment, said vector comprising a nucleic acid encoding said programmed nuclease is administered either simultaneously or after the vector comprising the nucleic acid encoding the base-editing nuclease. If delivered simultaneously, the payload can be engineered to have a delayed targeting process for the programmed nuclease leading to DNA double strand break.

BRIEF DESCRIPTION OF DRAWINGS

In order to better understand the subject matter that is disclosed herein and to exemplify how it may be carried out in practice, embodiments will be described, by way of non-limiting example, with reference to the accompanying drawings. With specific reference to the drawings, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention.

FIG. 1 depicts a method for modifying a naturally occurring bacteria in situ. Bacteria in absence of treatment produce molecules leading to pathogenicity such as inflammation. Upon treatment in the case of non-efficient target cell modification, only a fraction of the bacterial population is genetically modified to express a modified molecule that is non-pathogenic whereas non genetically modified bacteria are still producing the pathogenic variant. This heterogenous bacterial population and their associated molecules lead to mild disease state compared to the no treatment case. Finally, in case of an efficient target cell modification of all the population or a vast majority, the pathogenic variant of the molecule is not present anymore or in quantity low enough to have no pathogenicity and reach a healthy state.

FIG. 2 depicts a method for modification of bacterial antigens in a naturally occurring bacteria in situ where the bacterial antigen mimics a human protein. The bacterial antigen is presented by an antigen presenting cell (APC) to a T cell leading to its activation and an immune response targeted towards on one side the bacterial antigen and on the other side the human protein or self-antigen thus leading to auto-immune reaction.

FIG. 3 depicts a screening method for the modification of a naturally occurring bacteria in situ. Before treatment the patient is optionally getting sampled to detect and quantify potential bacterial targets. Then the treatment is administered on different forms (oral, systemic, topical) depending on the target microbiome localization. After treatment the patient is getting sampled to detect and/or quantify bacterial targets and the genetic modifications induced by the treatment.

FIGS. 4A-B presents graphs showing base editing of mCherry on the E. coli genome after transformation in vitro. FIG. 4A) Adenine base editing (ABE=ABE8e) of mCherry. The experiment was performed in the presence (48 colonies analysed) or absence (2 colonies analysed) of a guideRNA targeting the active site of mCherry (tripeptide: M71, Y72, G73). FIG. 4B) Cytosine base editing (CBE=evoAPOBEC1-nCas9-UGI) of mCherry. The experiment was performed in the presence (48 colonies analysed) or absence (2 colonies analysed) of a guideRNA inserting a stop codon into mCherry. Fluorescence was measured by flow cytometry (arbitrary units a.u.) of individual colonies (1 dot represents a single colony after overnight incubation on agar plates).

FIGS. 5A-C presents histograms and graphs showing base editing of β-lactamase on the E. coli genome after phagemid transduction in vitro. FIG. 5A) Titers of lambda packaged phagemids comprising a base editor payload (ABE=ABE8e, CBE=evoAPOBEC1-nCas9-UGI). FIG. 5B) Multiplicity of infection (MOI)-dependent adenine base editing (ABE) targeting the active site of β-lactamase gene (K71E) on the genome. FIG. 5C) Multiplicity of infection (MOI)-dependent cytosine base editing (CBE) of β-lactamase. Editing of the active site of β-lactamase diminishes cell growth on carbenicillin plates.

FIG. 6 presents histograms showing adenine base editing of β-lactamase after transduction into E. coli in oligoMM mice in vivo. The packaged phagemids titer for the in vivo experiment was 1.5×10⁹transduction units (tu)/μl. Stool samples were analysed 0, 6, and 48 hours post transduction (48, 96, 88 colonies, respectively). Cells were plated on streptomycin, chloramphenicol, and carbenicillin plates in order to analyse delivery and editing efficiency. Editing of the active site of β-lactamase (K71) results in a loss of cell growth on carbenicillin plates.

FIGS. 7 and 8 depict the plasmid maps of the constructed base editors. Adenine base editing was exemplarily performed by ABE8e (FIG. 7; SEQ ID NO: 2). ABE8e comprises an evolved TadA* gene fused to a nCas9 (D10A). Cytosine base editing was exemplarily performed by evoAPOBEC1-nCas9-UGI (FIG. 8; SEQ ID NO: 4). The UGI fused to the nCas9 (D10A) prevents the repair of U:G mismatches back into C:G base pairs. The DNA payloads carry a cos site for packaging into lambda phagemid particles.

FIG. 9 displays histograms showing prime editing of Red Fluorescent Protein (RFP) on the E. coli genome in vitro. The genomic RFP gene was amplified from 18 individual colonies and the resulting PCR fragments were sequenced. The editing efficiency was calculated from these data.

FIG. 10 displays a graph showing adenine base editing of β-lactamase on the E. coli genome after packaged phagemid transduction in vitro using a non-replicative payload based on a primase-helicase. An MG1655 strain encoding the β-lactamase gene was transduced in the presence or absence of the primase-helicase protein expressed inside the cell. Transduced cells were plated on LB and LB (carbenicillin) plates 2 hours post transduction at different multiplicity of infections (MOI). The next day, base editing efficiency was analyzed via colony counting.

FIG. 11 displays a picture showing transformation of a 2.3 kb payload containing the primase-origin of replication in a production strain harboring an inducible primase RBS library in trans.

FIG. 12 displays histograms comparing packaged phagemids titers obtained with a plasmid containing the primase-ori in production strains tested against 7 different primase RBS. Right column, in black, control plasmid with a p15a-derived origin of replication. Titers shown are after a 10× concentration.

FIG. 13 displays a picture comparing cells transduced with a primase-ori plasmid (top row) and a p15a-based packaged phagemids on LB agar plus 25 μg/mL chloramphenicol.

FIG. 14 displays histograms showing adenine base editing of β-lactamase after packaged phagemid transduction into E. coli in ten oligoMM mice using a non-replicative payload based on a primase-helicase. Delivery and editing efficiency of adenine base editing in vivo. The packaged phagemid titer for the in vivo experiment was 1.5*10¹⁰tu/μl. Stool samples were analysed 24h post transduction. Cells were plated on streptomycin and streptomycin/carbenicillin in order to analyse editing efficiency (20 colonies per mouse). Editing of the active site of β-lactamase (K71) resulted in a loss of cell growth on carbenicillin plates. After 24 hours, base editing efficacy was ˜75% of the whole population on average.

TABLES

Table 1 presents gut bacterial species carrying candidate mimic peptide, amino acids sequence of related mimic peptide and Uniprot ID of bacterial and human protein containing each mimic peptide.

Table 2 presents nucleic acid sequences encoding drug-metabolizing gene products (identified by start nucleotide and end nucleotide in the listed contigs).

DETAILED DESCRIPTION OF INVENTION

The invention encompasses compositions, kits and methods, in particular non-therapeutic methods, for modifying a naturally occurring bacteria in situ. The invention further encompasses compositions, kits and methods, in particular non-therapeutic methods, for modifying a non-naturally occurring bacteria, such as one with an ex vivo genetic modification, in situ. The compositions, kits and methods of the invention genetically modify deleterious bacterial strains within the host microbiome to turn them into non-deleterious strains for the host without directly killing these strains.

The invention further encompasses modifications that improve or functionalize non deleterious bacteria. The invention further includes methods for screening for genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth or on any bacterial function, for increasing the ratio of modified bacteria vs non-modified bacteria in situ, for increasing the chance that this approach leads to a positive outcome in a patient.

Preferably, the genetic modifications are modifications of a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence. Thus, the method includes generating no cleavages in the DNA sequence, generating a nick in one strand of the DNA sequence, or generating a staggered nicks in both strands of the DNA sequence, that do not lead to a double strand break in the DNA sequence.

Provided herein are compositions, kits and methods of treating, preventing or curing microbiome-associated diseases or disorders by modulating either the molecules expressed and/or secreted by bacterial populations of the microbiome or their expression/secretion levels, in a specific manner that will result in the modification of the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health, and which will not result in the direct death of these populations, a direct significant inhibition of their growth or impairment of major bacterial function. The invention also concerns a vector encoding enzymes or systems for inducing genetic modifications in naturally occurring bacteria in situ for use for treating, preventing or curing a microbiome-associated disease or disorder by modulating either the molecules expressed and/or secreted by bacterial populations of the microbiome or their expression/secretion levels, in particular in a specific manner that will result in the modification of the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health, and which will not result in the direct death of these populations, a direct significant inhibition of their growth or impairment of major bacterial function. The invention also concerns the use of a vector encoding enzymes or systems for inducing genetic modifications in naturally occurring bacteria in situ in the manufacture of a medicament intended to treat, prevent or cure a microbiome-associated disease or disorder by modulating either the molecules expressed and/or secreted by bacterial populations of the microbiome or their expression/secretion levels, in particular in a specific manner that will result in the modification of the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health, and which will not result in the direct death of these populations, a direct significant inhibition of their growth or impairment of major bacterial function.

The invention encompasses the use of a vector that can transduce with high efficiency a nucleic acid, preferably a plasmid or a phagemid, into a bacterial population within the microbiome that allows the expression of an exogenous enzyme that will modify a DNA or gene sequence. The bacterial population can be a mixed bacterial population, comprising different strains of the same species; alternatively, the bacterial population can be a mixed bacterial population, comprising different strains of different species. In some embodiments, the DNA sequence or gene has a direct or indirect effect on the interactions of the bacteria with the host. Thus, the invention encompasses vectors for use in transducing with high efficiency a nucleic acid, preferably a plasmid or a phagemid, into a bacterial population.

In some embodiments, the DNA sequence or gene having a direct effect includes a DNA sequence or gene expressing a toxin that interacts with host cells, or a bacterial protein or peptide that includes a sequence of amino acids that mimic a sequence of amino acids present in the host proteins or peptides.

In some embodiments, the DNA sequence or gene having an indirect effect includes DNA sequences or genes that encode for an enzyme expressed, displayed on the membrane or secreted by the bacteria that is involved in the internal production or modification of a sugar, lipid, metabolite or protein that is present inside the bacteria, expressed or displayed on the membrane of the bacteria, secreted by the bacteria or imported by the bacteria.

Preferably, the precise modification of the DNA sequence or gene sequence is performed so that it minimizes any effect on the ability of the bacteria to grow and interact with other microorganisms in its biological environment, but modifies its interaction with the host or its growth or resistance potential during a treatment.

Methods of Genetic Modification

The invention encompasses methods of modifying a naturally occurring bacteria in situ. Preferably, the genetic modification does not lead to the death of bacteria. More preferably, the genetic modification results in less than a 5%, 10%, 20%, or 50% growth disadvantage of the modified bacteria in vivo due to the genetic modification. Even more preferably, the genetic modification does not result in any growth disadvantage of the modified bacteria in vivo due to the modification. Preferably, the genetic modification is a modification of a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence,

In a preferred embodiment, the bacteria are contacted in situ with a vector that can transfer with high efficiency a nucleic acid into the bacteria to express an exogenous enzyme in the bacteria that results in a genetic modification. In a preferred embodiment, the exogenous enzyme can result in this genetic modification through base editing strategies where dCas9 (dead-Cas9) or nCas9 (nickase Cas9) is fused to cytosine or adenosine deaminase domain and directed to the target sequence to make the desired modification.

In a preferred embodiment, the exogenous enzyme can result in this genetic modification through prime editing strategies where dCas9 (dead-Cas9) or nCas9 (nickase Cas9) is fused to reverse transcriptase domain and directed to the target sequence to make the desired modification with the help of a pegRNA (prime editing guide RNA).

Nevertheless, the invention also contemplates introducing a double strand break or a single strand break i.e. a nick in the bacterial DNA at a specific sequence, for example with a CRISPR/Cas system, together with non-homologous end joining (NHEJ) or homologous recombination (HR) to generate the desired genetic modification. Preferably, the double strand break or the single strand break is generated in the presence of an editing template comprising homologous regions with DNA regions located around the specific sequence located in the bacterial DNA.

The genetic modification can be a point mutation(s), a deletion(s), insertion(s) or any combination thereof.

In some embodiments, the genetic modification can inactivate, reduce, increase or induce the expression of a DNA sequence or gene. The genetic modification can be in the translated or untranslated regions of a gene. The genetic modification can be in the promoter region of a gene or within any other region involved in gene regulation.

In some embodiments, the DNA sequence or gene inactivation can be a point mutation(s) inside the coding sequence (starts with start codon, ends with stop codon). More precisely, the DNA sequence or gene inactivation can be performed by a point mutation(s) converting one or several codons to stop codon (TAA, TAG, TGA). Alternatively, the DNA sequence or gene inactivation can be performed by a point mutation(s) converting the start codon (ATG, GTG, TTG) or any in-frame start codon in 5, 10, 20, 50, 100 bp of the predicted start codon into a non-start codon or a stop codon. Alternatively, the DNA sequence or gene inactivation can be performed by point mutation(s) introducing rare codons inside the codon sequence. Alternatively, the DNA sequence or gene inactivation can be performed by point mutation(s) introducing non-synonymous amino acid change(s) in a catalytic site making the protein inactive for the function associated to this catalytic site. Alternatively, the DNA sequence or gene inactivation can be performed by point mutation(s) introducing non-synonymous amino acid change(s) in a site involving binding other molecules where the interaction is necessary for the protein activity.

In some embodiments, the DNA sequence or gene inactivation can be a point mutation(s) outside the coding sequence. Point mutation(s) can be in the promoter region of a gene (e.g. −35 bp region, −10 bp region, transcription start site (TSS)), in the Ribosome Binding Site (RBS) of the gene or within any other region involved in regulation (e.g. transcription factor binding site, operator binding site, riboswitch . . . ).

In some embodiments, the genetic modification can lead to DNA sequence or gene activation.

In some embodiments, the genetic modification can be a point mutation(s) that revert a previously characterized mutation that inactivate, decrease or increase the activity of a gene or pathway.

In some embodiments, the genetic modification can be a point mutation(s) leading to modulation of DNA sequence or gene expression and regulation. Point mutation(s) can be in promoter region of a gene (e.g. −35 bp region, −10 bp region, transcription start site (TSS)), in the Ribosome Binding Site (RBS) of the gene, within any other region involved in regulation (e.g., transcription factor binding site, operator binding site, RNAse recognition site, riboswitch, methylation sit, etc.) or in any other DNA sequence or gene regulating the DNA sequence or gene of interest such as a repressor, an antisense RNA, an activator.

In some embodiments, the genetic modification can be point mutation(s) leading to modulation of post translational modification(s) (e.g., phosphorylation, glycosylation, acetylation, pupylation, etc.). More particularly the modification can be a point mutation in the post translational modification site. Alternatively, the genetic modification can disrupt the DNA sequence or gene responsible for post-translational modification(s).

In another embodiment, the genetic modification is a point mutation(s) that revert a mutation that leads to an increase of pathogenicity.

In a particular embodiment, the genetic modification does not integrate a phage genome or exogenous DNA into the host bacterial chromosome or endogenous plasmid(s). In a particular embodiment, the genetic modification does not result in expression of an exogenous protein from an integrated exogenous DNA in the host bacterial chromosome or endogenous plasmid(s). In a more particular embodiment, the genetic modification does not involve either NHEJ or HR endogenous repair mechanism of the host bacteria.

In some embodiments, the genetic modification results in the change in at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 100, 200, 500, etc. amino acids to a different amino acid.

The invention encompasses methods, in particular non-therapeutic methods, of modulating host-microbiome interaction by genetically modifying naturally occurring bacteria in situ. Preferably, the naturally occurring bacteria is involved in microbiome associated disorder or disease. In preferred embodiments, the method comprises genetically modifying a DNA sequence responsible for the microbiome associated disorder or disease in the naturally occurring bacteria in situ, wherein the genetic modification reduces the effects of the microbiome associated disorder or disease, and wherein the genetic modification does not lead to the death of bacteria. The invention further encompasses a vector encoding enzymes or systems for inducing genetic modifications in naturally occurring bacteria in situ for use in a method for reducing the effects of a microbiome associated disorder or disease, wherein said vector genetically modifies a DNA sequence, in the naturally occurring bacterial in situ, responsible for said microbiome associated disorder or disease, and wherein the genetic modification does not lead to the death of bacteria. Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In some embodiments, the genetic modification occurs within a pathogenic bacterial DNA sequence or gene encoding a virulence factor to block pathogenesis, which de-facto might reduce the fitness of the bacteria, since virulence factor often confer a fitness advantage of the pathogenic bacteria over its bacterial competitors. This might for example lead to a lower growth-rate.

In other embodiments, the genetic modification occurs within commensal bacteria or opportunistic pathogens, and the modification has a small or no impact on the growth rate of this bacteria as a commensal bacteria.

The invention encompasses methods to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the human or animal microbiome. In preferred embodiments, the method comprises contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population, wherein the genetic modification of the DNA sequence coding for the immunogenic component results in loss of the immunogenic effect of said immunogenic component, and wherein the genetic modification does not lead to the direct death of the bacteria. The invention further encompasses a vector encoding enzymes or systems for inducing genetic modifications for use in a method to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the human or animal microbiome. In preferred embodiments, said vector generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population, wherein the genetic modification of the DNA sequence coding for the immunogenic component results in loss of the immunogenic effect of said immunogenic component, and wherein the genetic modification does not lead to the direct death of the bacteria.

Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In some embodiments, the genetic modification results in a change of amino acid in a mimic peptide and renders the mimic peptide not immunogenic or not recognized by the immune system. In some embodiments, the genetic modification results in a change of sugar profile on the bacterial membrane. In some embodiments, the genetic modification results in a change of amino acid in a protein sequence that results in a change of sugar profile on the bacterial membrane. In some embodiments, the genetic modification results in a change of lipid profile on the bacterial membrane. In some embodiments, the genetic modification results in a change of amino acid in a protein sequence that results in a change of lipid profile on the bacterial membrane. In some embodiments, the genetic modification results in a change at the protein sequence level leading to an inactive catalytic site. In some embodiments, the genetic modification renders a binding site with a human cell receptor non-functional. In some embodiments, the genetic modification renders the bacteria more sensitive to detection by human immune cells.

Modification of a Bacterial Toxin Gene Sequence

In some embodiment, the genetic modification is made in a toxin gene sequence so that the toxin is still produced, expressed and or secreted but renders its toxigenic effect null, resulting in the modification of one or multiple amino acids of the catalytic site of the enzyme so that it cannot exert its toxigenic effect on the host cells.

Alternatively, the genetic modification is made in a toxin gene sequence so that the toxin gene sequence is not expressed or disrupted, resulting in the inactivation of the toxin.

The targeted bacterial toxin can be an exotoxin or endotoxin. Exotoxins are generated and actively secreted; endotoxins remain part of the bacteria. The response to a bacterial toxin can involve severe inflammation and can lead to sepsis.

Preferred toxins include Colibactin of E. coli, Toxin A and other enzymes (e.g., hemolysin, leukotoxin, exfoliative toxin, enterotoxin, and toxic-shock syndrome toxin-1 (TSST-1)) from Staphylococcus aureus as described in Tam and Torres, Microbiol Spectr. 2019 March; 7(2), which is hereby incorporated by reference, and fragilysin (Bft) from Enterotoxigenic (ETBF) strains of Bacteroides fragilis, Botulinum neurotoxin, Tetanus toxin, Diphteria toxin, Anthrax toxin, Alpha toxin, Pertussis toxin, Shiga toxin, Heat-stable enterotoxin (E. coli ST), or any toxin described in Henkel et al., (Toxins from Bacteria in EXS. 2010; 100: 1-29, which is hereby incorporated by reference).

By “colibactin” is meant herein a secondary metabolite synthetized by the clbA-S genes present in the 54-kb pathogenicity pks island, a genetic island encoding a non-ribosomal peptide synthetase-polyketide synthase (NRPS-PKS) assembly line in Enterobacteriaceae. Colibactin is typically produced as a prodrug moiety that is exported in the periplasm by the efflux pump ClbM and then hydrolyzed by the periplasmic membrane-bound ClbP protein with a peptidase activity, which releases the active colibactin.

In preferred embodiments, the genetic modification is a point mutation(s) leading to toxin gene disruption such as described previously.

Preferably, the bacteria with the genetic modification do not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

Preferably, the genetic modification(s) are done so that a single genetic mutation cannot revert the activity of the toxin. This can be achieved by changing the original amino acid for another amino acid that cannot be reverted to original by a single substitution.

In one embodiment, the method comprises making a genetic modification in the ClbP gene in pks+ E. coli that result in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity. In a particular embodiment, the genetic modification is in the ClbP gene in pks+ E. coli and results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, while maintaining its antagonistic activity.

As used herein, the ClbP gene is typically of sequence SEQ ID NO: 2316 and typically encodes a protein of sequence SEQ ID NO: 2317.

Preferably, the genetic modification is at codons of the ClbP gene encoding amino acids S95 or K98 of the protein encoded by the ClbP gene, in particular at codons of the ClbP gene encoding amino acids S95 or K98 of SEQ ID NO: 2317. Most preferably, the genetic modification is a mutation S95A, S95R or K98T in the ClbP gene.

In some embodiments, the genetic modification is made in a Shigella toxin gene such as, without limitation, stx1 and stx2. In some embodiments, the genetic modification is made in a E. coli toxin gene such as, without limitation, Stx1 (VT1), Stx2 (VT2), Stx2a (VT2a), Stx2b (VT2b), Stx2c (VT2c), Stx2d (VT2d), Stx2e (VT2e) and Stx2f (VT2f), Stx2h (VT2h), stx2k.

Modification of Other Bacterial Virulence Gene Sequence

In one embodiment, the modification can be made in and inactivate a virulence factor. A virulence factor can be any substance produced by a pathogen that alters host-pathogen interaction by increasing the degree of damage done to the host. Virulence factors are used by pathogens in many ways, including, for example, in cell adhesion or colonization of a niche in the host, to evade the host's immune response, to facilitate entry to and egress from host cells, to obtain nutrition from the host, or to inhibit other physiological processes in the host. Virulence factors can include enzymes, endotoxins, adhesion factors, motility factors, factors involved in complement evasion, scavenging factors and factors that promote biofilm formation.

In some embodiments, the genetic modification is made in a E. coli virulence factor gene such as, without limitation, EHEC-HlyA, fimA, fimF, fimH, neuC, kpsE, sfa, foc, iroN, aer, iha, papC, papGI, papGII, papGIII, hlyC, cnf1, hra, sat, ireA, usp ompT, ibeA, malX, fyuA, irp2, traT, afaD, ipaH, eltB, estA, bfpA, eaeA, espA, aaiC, aatA, TEM, CTX, SHV, csgA, csgB, csgC, csgD, csgE, csgF, csgG, csgH, or genes within T1SS, T2SS, T3SS, T4SS, T5SS, T6SS (secretion systems).

In one embodiment, the method comprises making a genetic modification in the FimH gene in E. coli that results in reverting the following mutations: N70S and S78N associated with AEIC strains³. In a particular embodiment, the genetic modification is made in the FimH gene in E. coli.

In the context of the invention, the FimH gene typically encodes a Type 1 fimbrin D-mannose specific adhesin. The FimH gene is typically of sequence SEQ ID NO: 2319 and typically encodes a protein of sequence SEQ ID NO: 2318.

In one embodiment, the genetic modification is made in the FimH gene in E. coli and preferably results in reverting the mutations N70S and S78N associated with AEIC strains.

In one embodiment, the method comprises making a genetic modification in the blc gene in E. coli that result in reverting the mutation G84E (G251A at the nucleotide level) potentially associated with gut inflammation⁴.

In the context of the invention, the blc gene typically encodes an Outer membrane lipoprotein Blc. The bcl gene is typically of sequence SEQ ID NO: 2321 and typically encodes a protein of sequence SEQ ID NO: 2320.

In one embodiment, the genetic modification is made in the blc gene in E. coli and preferably results in reverting the mutation G84E (G251A at the nucleotide level) potentially associated with gut inflammation.

In some embodiments, the genetic modification is made in a Yersinia pestis virulence factor gene such as, without limitation, yscF (plasmid-borne (pCDI) T3SS external needle subunit).

In some embodiments, the genetic modification is made in a Francisella tularensis virulence factor gene such as, without limitation, fslA.

In some embodiments, the genetic modification is made in a Bacillus anthracis virulence factor gene such as, without limitation, pag (Anthrax toxin, cell-binding protective antigen).

In some embodiments, the genetic modification is made in a Vibrio cholera virulence factor gene such as, without limitation, ctxA and ctxB (cholera toxin), tcpA (toxin co-regulated pilus), and toxT (master virulence regulator).

In some embodiments, the genetic modification is made in a Pseudomonas aeruginosa virulence factor genes such as, without limitation, pyoverdine (e.g., sigma factor pvdS, biosynthetic genes pvdL, pvdI, pvdJ, pvdH, pvdA, pvdF, pvdQ, pvdN, pvdM, pvdO, pvdP, transporter genes pvdE, pvdR, pvdT, opmQ), siderophore pyochelin (e.g., pchD, pchC, pchB, pchA, pchE, pchF and pchG, and toxins (e.g., exoU, exoS and exoT).

In some embodiments, the genetic modification is made in a Klebsiella pneumoniae virulence factor gene such as, without limitation, fimA (adherence, type I fimbriae major subunit), and cps (capsular polysaccharide).

In some embodiments, the genetic modification is made in an Acinetobacter baumannii virulence factor gene such as, without limitation, ptk (capsule polymerization) and epsA (assembly).

In some embodiments, the genetic modification is made in a Salmonella enterica Typhi virulence factor gene such as, without limitation, MIA (invasion, SPI-1 regulator), ssrB (SPI-2 regulator), and those associated with bile tolerance, including efflux pump genes acrA, acrB and tolC.

In some embodiments, the genetic modification is made in a Fusobacterium nucleatum virulence factor gene such as, without limitation, FadA and TIGIT.

In some embodiments, the genetic modification is made in a Bacteroides fragilis virulence factor gene such as, without limitation, bft.

In some embodiments, the genetic modification is made in a Cutibacterium acnes porphyrins gene, a CAMP-factor (CAMP1, CAMP2, CAMP3, CAMP4), Hyaluronate lyase (HYL-IB/II, HYL-IA), Lipases (GehA, GehB), Haemolysins, Sialidases, Endoglycoceramidases, Endo-ß-N-acetylglucosaminidase, Dermatan sulphate adhesin (DsA1, DsA2), Proline-Threonine Repeats (PTRs) or in any virulence factors included on the acne associated genomic loci 1, 2, 3 (plasmid), 4 such as a tight adhesion locus (tad), Streptolysin S-associated genes (sag), nonribosomal peptide synthetases (NRPS) as described in Tomida et al⁵, which is hereby incorporated by reference.

Modification of a Mimic Peptide Gene Sequence

In some embodiments, the genetic modification is made in a mimic peptide gene sequence so that the homology with the human peptide sequence is reduced, and therefore results in the mimic peptide being not recognized anymore by the host immune system. Mimic peptides of particular interest are bacterial mimic peptides that are associated with auto-immune diseases, for example those mentioned in Negi et al.⁶, which are hereby incorporated by reference. Of particular interest are the gene sequences encoding any of the mimic peptides in S1 Table of Negi et al.

In a particular embodiment, the mimic peptide is one of the candidate mimic peptides disclosed in Table 1 below. In a particular embodiment, said mimic peptide is selected from the group consisting of the peptides of sequence SEQ ID NO: 19 to 2313.

In preferred embodiments, the mimic peptide is from Proteobacteria or Firmicutes. Of particular interest are the gene sequences encoding 24 gut bacterial peptides identified by Negi et al. with homology to four human peptides from Low molecular weight phosphotyrosine protein phosphatase, Aldehyde dehydrogenase family 3 member B1, Maleylacetoacetate isomerase and Uracil-DNA glycosylase. These gene sequences can be modified to reduce the homology with the human sequences and prevent cross-reactivity of those recognized by the host immune system with the human counterpart.

In a preferred embodiment, the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene. Preferably, the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein with the genetic modification shows lower homology with human MYH6 cardiac peptide as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification². Preferably the genetic modification is performed in the peptides fragment recognized as epitope by the human immune system leading to a weaker or absence of epitope recognition by the human immune system².

In a preferred embodiment, the genetic modification is in human commensal bacteria encoding a Ro60 ortholog gene. Preferably, the Ro60 protein resulting from the genetic modification shows lower homology with human Ro60 peptide as compared to the original protein. Preferably the genetic modification is performed in the DNA sequence corresponding to peptides fragment recognized as epitope by the human immune system leading to a weaker or absence of epitope recognition by the human immune system. Preferably the human bacterial commensal targeted for genetic modification are: Propionibacterium propionicum, Corynebacterium amycolatum, Actinomyces massiliensis, Bacteroides thetaiotaomicron. Even more preferably the human bacterial commensal targeted for genetic modification is Propionibacterium propionicum⁷.

In a preferred embodiment, the genetic modification is in human commensal bacterial DNA sequence encoding a peptide that mimic insulin B 9-25, a self-epitope involved in type 1 diabetes⁸. The genetic mutation reduces homology to the insulin B9-25 epitope SHLVEALYLVCGERGFF (SEQ ID NO: 9). In a preferred embodiment, the target bacteria belong to the Firmicutes phylum. In a preferred embodiment, the target gene in the target bacteria is part of the transketolase N superfamily⁸.

In a preferred embodiment, the genetic modification is in Roseburia intestinalis encoding a peptide that mimic the epitope of the autoantigen β₂-glycoprotein I (β₂GPI), a self-epitope involved in antiphospholipid syndrome (APS). The genetic mutation is reducing homology to the T cell (β₂GPI) epitope KVSFFCKNKEKKCSY (SEQ ID NO: 10) and/or B cell epitope VSRGGMRKFIC (SEQ ID NO: 11)²⁸.

Modification of an Antibiotic-Resistance Gene Sequence

In some embodiments, the modification is made in an antibiotic-resistance gene sequence, carried on the chromosome or on a plasmid, to render the bacteria sensitive to an antibiotic without exerting a direct selective pressure on the bacteria in the absence of the related antibiotic.

In some embodiment, the genetic modification is made to revert mutations in endogenous genes, some of which are essential to the bacteria, that confer resistance to antibiotics such as: RpoB rifampicin resistant mutant, 23S rRNA erythromycin resistant mutant, GyrA (fluoro) quinolone resistant mutant, GyrB (fluoro) quinolone resistant mutant, RpsL streptomycin resistant mutant, DHFR trimethoprim resistant mutant, fusA fusidic acid resistant mutant, fmt actinonin resistant mutant, gidB streptomycin resistant mutant, ompR multidrug resistant mutant, marR multidrug resistant mutant, Ion multidrug resistant mutant, mgrB colistin resistant mutant, pmrA colistin resistant mutant, acrR multidrug resistant mutant, cysB amdinocillin resistant mutant, 16S rRNA methyltransferase.

In some embodiments, the antibiotic resistance gene can be, without limitation, GyrB, ParE, ParY, AAC(1), AAC(2′), AAC(3), AAC(6′), ANT(2″), ANT(3″), ANT(4′), ANT(6), ANT(9), APH(2″), APH(3″), APH(3′), APH(4), APH(6), APH(7″), APH(9), ArmA, RmtA, RmtB, RmtC, Sgm, AER, BLA1, CTX-M, KPC, SHV, TEM, BlaB, CcrA, IMP, NDM, VIM, ACT, AmpC, CMY, LAT, PDC, OXA β-lactamase, mecA, Omp36, OmpF, PIB, bla (blaI, blaR1) and mec (mecI, mecR1) operons, Chloramphenicol acetyltransferase (CAT), Chloramphenicol phosphotransferase, Ethambutol-resistant arabinosyltransferase (EmbB), MupA, MupB, Integral membrane protein MprF, Cfr 23S rRNA methyltransferase, Rifampin ADP-ribosyltransferase (Arr), Rifampin glycosyltransferase, Rifampin monooxygenase, Rifampin phosphotransferase, DnaA, RbpA, Rifampin-resistant beta-subunit of RNA polymerase (RpoB), Erm 23S rRNA methyltransferases, Lsa, MsrA, Vga, VgaB, Streptogramin Vgb lyase, Vat acetyltransferase, Fluoroquinolone acetyltransferase, Fluoroquinolone-resistant DNA topoisomerases, Fluoroquinolone-resistant GyrA, GyrB, ParC, Quinolone resistance protein (Qnr), FomA, FomB, FosC, FosA, FosB, FosX, VanA, VanB, VanD, VanR, VanS, Lincosamide nucleotidyltransferase (Lin), EreA, EreB, GimA, Mgt, Ole, Macrolide phosphotransferases (MPH), MefA, MefE, Mel, Streptothricin acetyltransferase (sat), Sul1, Sul2, Sul3, sulfonamide-resistant FoIP, Tetracycline inactivation enzyme TetX, TetA, TetB, TetC, Tet30, Tet31, TetM, TetO, TetQ, Tet32, Tet36, MacAB-TolC, MsbA, MsrA,VgaB, EmrD, EmrAB-TolC, NorB, GepA, MepA, AdeABC, AcrD, MexAB-OprM, mtrCDE, EmrE, adeR, acrR, baeSR, mexR, phoPQ, mtrR, or any antibiotic resistance gene described in the Comprehensive Antibiotic Resistance Database at card. mcmaster.ca/.

In preferred embodiments, the antibiotic is selected from the group consisting of penicillins such as penicillin G, penicillin K, penicillin N, penicillin 0, penicillin V, methicillin, benzylpenicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, ampicillin, amoxicillin, pivampicillin, hetacillin, bacampicillin, metampicillin, talampicillin, epicillin, carbenicillin, ticarcillin, temocillin, mezlocillin, and piperacillin; cephalosporins such as cefacetrile, cefadroxil, cephalexin, cefaloglycin, cefalonium, cephaloridine, cefalotin, cefapirin, cefatrizine, cefazaflur, cefazedone, cefazolin, cefradine, cefroxadine, ceftezole, cefaclor, cefonicid, cefprozil, cefuroxime, cefuzonam, cefmetazole, cefotetan, cefoxitin, loracarbef, cefbuperazone, cefminox, cefotetan, cefoxitin, cefotiam, cefcapene, cefdaloxime, cefdinir, cefditoren, cefetamet, cefixime, cefmenoxime, cefodizime, cefotaxime, cefovecin, cefpimizole, cefpodoxime, cefteram, ceftamere, cefti buten, ceftiofur, ceftiolene, ceftizoxime, ceftriaxone, cefoperazone, ceftazidime, latamoxef, cefclidine, cefepime, cefluprenam, cefoselis, cefozopran, cefpirome, cefquinome, flomoxef, ceftobiprole, ceftaroline, ceftolozane, cefaloram, cefaparole, cefcanel, cefedrolor, cefempidone, cefetrizole, cefivitril, cefmatilen, cefmepidium, cefoxazole, cefrotil, cefsumide, ceftioxide, cefuracetime, and nitrocefin; polymyxins such as polysporin, neosporin, polymyxin B, and polymyxin E, rifampicins such as rifampicin, rifapentine, and rifaximin; Fidaxomicin; quinolones such as cinoxacin, nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, rosoxacin, ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, nadifloxacin, norfloxacin, ofloxacin, pefloxacin, rufloxacin, balofloxacin, grepafloxacin, levofloxacin, pazufloxacin, temafloxacin, tosufloxacin, clinafloxacin, gatifloxacin, gemifloxacin, moxifloxacin, sitafloxacin, trovafloxacin, prulifloxacin, delafloxacin, nemonoxacin, and zabofloxacin; sulfonamides such as sulfafurazole, sulfacetamide, sulfadiazine, sulfadimidine, sulfafurazole, sulfisomidine, sulfadoxine, sulfamethoxazole, sulfamoxole, sulfanitran, sulfadimethoxine, sulfametho-xypyridazine, sulfametoxydiazine, sulfadoxine, sulfametopyrazine, and terephtyl; macrolides such as azithromycin, clarithromycin, erythromycin, fidaxomicin, telithromycin, carbomycin A, josamycin, kitasamycin, midecamycin, oleandomycin, solithromycin, spiramycin, troleandomycin, tylosin, and roxithromycin; ketolides such as telithromycin, and cethromycin; fluoroketolides such as solithromycin; lincosamides such as lincomycin, clindamycin, and pirlimycin; tetracyclines such as demeclocycline, doxycycline, minocycline, oxytetracycline, and tetracycline; aminoglycosides such as amikacin, dibekacin, gentamicin, kanamycin, neomycin, netilmicin, sisomicin, tobramycin, paromomycin, and streptomycin; ansamycins such as geldanamycin, herbimycin, and rifaximin; carbacephems such as loracarbef; carbapenems such as ertapenem, doripenem, imipenem (or cilastatin), and meropenem; glycopeptides such as teicoplanin, vancomycin, telavancin, dalbavancin, and oritavancin; lincosamides such as clindamycin and lincomycin; lipopeptides such as daptomycin; monobactams such as aztreonam; nitrofurans such as furazolidone, and nitrofurantoin; oxazolidinones such as linezolid, posizolid, radezolid, and torezolid; teixobactin, clofazimine, dapsone, capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, pyrazinamide, rifabutin, arsphenamine,chloramphenicol, fosfomycin, fusidic acid, metronidazole, mupirocin, platensimycin, quinupristin (or dalfopristin), thiamphenicol, tigecycline, tinidazole, trimethoprim, alatrofloxacin, fidaxomicin, nalidixic acid, rifampin, derivatives and combination thereof.

Modification to a Conserved Sequence

In some embodiments, the modification of the amino-acid sequence is made so that the edited sequence corresponds to an amino-acid sequence encoding for the same or a related protein/function/activity coming from one or multiple different strains from the same species, or from a related species, or from the same genus, or from any other bacteria from the microbiome. The edited sequence can correspond to a paralog, ortholog or analog of the original sequence.

This modification can reduce the potential selective pressure applied to the edited bacteria by ensuring a relatively similar function while not having the same exact amino-acid sequence.

Modification of DNA Sequences Involved in Interactions Between Bacteria and Compounds Administered to or Produced by the Subject or Produced by Other Bacteria

The invention also concerns a method to modify in situ interaction of a bacteria from a microbiome of a subject with a compound administered to or produced by said subject or produced by other bacteria from said subject, by modifying at least one bacterial DNA sequence involved in the interaction of said bacteria with said compound, said bacterial DNA sequence being expressed by a bacterial population of the host microbiome, said method comprising:

wherein the genetic modification of said at least one DNA sequence results in a modification of the interaction of the bacteria with said compound; and

wherein the genetic modification does not lead to the direct death of the bacteria.

By “interaction of a bacteria with a compound administered to or produced by a subject or produced by other bacteria from said subject” is meant any type of interaction, inducing or not a modification in the structure and/or activity of said compound, and involving any component of the bacteria (including enzymes, receptors, channels, sugars, lipids, etc. . . . ) in any location of said bacteria (e.g. at the membrane, capsule, in the cytoplasm, etc). Said interaction of a bacteria with a compound administered to or produced by the subject or produced by other bacteria encompasses (i) modification of said compound by said bacteria and/or (ii) competition between said compound and a molecule produced and/or secreted by said bacteria for a ligand from said subject and/or (iii) binding/adsorption of said compound by said bacteria.

By “ligand” is meant herein a substance binding, in particular specifically binding, to a compound of interest. In the context of the invention, ligands from the subject encompasses receptors, enzymes, immune molecules, etc. . . . , able to bind said compound of interest.

Said compound administered to said subject can be any type of compound such as a drug, a prebiotic, a cosmetic agent, a food supplement, etc. . . . .

Said compound produced by the subject may be, without limitation, bile acids (such as taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, deoxycholic acid, lithocholic acid, and derivatives of cholic, chenodeoxycholic and deoxycholic acids), hormones (such as Adrenaline (or epinephrine), Melatonin, Noradrenaline (or norepinephrine), Triiodothyronine, Thyroxine, Dopamine, Prostaglandins, Leukotrienes, Prostacyclin, Thromboxane, Amylin, Anti-Müllerian hormone (or Müllerian-inhibiting factor/hormone), Adiponectin, Adrenocorticotropic hormone (or corticotropin), Angiotensinogen, Angiotensin, Antidiuretic hormone (or vasopressin, arginine vasopressin), Atrial natriuretic peptide (or atriopeptin), Brain natriuretic peptide, Calcitonin, Cholecystokinin, Corticotropin-releasing hormone, Cortistatin, Enkephalin, Endothelin, Erythropoietin, Follicle-stimulating hormone, Galanin, Gastric inhibitory polypeptide, Gastrin, Ghrelin, Glucagon, Glucagon-like peptide-1, Gonadotropin-releasing hormone, Growth hormone-releasing hormone, Hepcidin, Human chorionic gonadotropin, Human placental lactogen, Growth hormone, Inhibin Peptide, Insulin, Insulin-like growth factor (or somatomedin), Leptin, Lipotropin, Luteinizing hormone, Melanocyte stimulating hormone, Motilin, Orexin, Osteocalcin, Oxytocin (or pitocin), Pancreatic polypeptide, Parathyroid hormone, Pituitary adenylate cyclase-activating peptide, Prolactin (or leuteotropic hormone), Prolactin-releasing hormone, Relaxin, Renin, Secretin, Somatostatin (or growth hormone-inhibiting hormone or growth hormone release-inhibiting hormone or somatotropin release-inhibiting factor or somatotropin release-inhibiting hormone), Thrombopoietin, Thyroid-stimulating hormone (or thyrotropin), Thyrotropin-releasing hormone, Vasoactive intestinal peptide, Guanylin, Uroguanylin, Testosterone, Dehydroepiandrosterone, Androstenedione, Di hydrotestosterone, Aldosterone, Estradiol, Estrone, Estriol, Cortisol, Progesterone, Calcitriol or Calcidiol) or perspiration compounds.

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for a drug-metabolizing gene product, in particular a drug-targeting enzyme, expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the gene coding for the drug-metabolizing gene protein, in particular the drug-targeting enzyme, results in a modification of the drug metabolism in the host;

wherein genetic modification does not lead to the direct death of the bacteria.

By “drug metabolism” is meant herein the biotransformation of pharmaceutical substances in the body. In the context of the invention, drug metabolism encompasses both the pathway leading to the elimination of the drug and the more general evolution of the drug activity in the subject one administered to said subject.

Said modification of the metabolism of a given drug may be selected from the group consisting of preventing transformation of the given drug into a toxic compound for the host, preventing hydrolysis of the given drug thus leading to a prolonged activity of said drug, an enzymatic modification of the given drug leading to an increased and/or prolonged activity of said drug, a transformation of said given drug into an active or more active compound, a modification preventing reactivation of detoxified compounds from a given drug.

Said given drug may be selected from the group consisting of Nicardipine.HCl, Risperidone, Tolcapone, Azathioprine, Entacapone, Exemestane, Nimodipine, Capsaicin, Dexamethasone, Ethacrynic Acid, Rifampin (Rifampicin), Sulindac, Vorinostat, Dolasetron, Mycophenolate Mofetil, Zidovudine (3′-Azido-3′-Deoxythymidine), Allopurinol, Betamethasone, Bisacodyl, Estradiol, Famciclovir, Flutamide, Hydrocortisone, Hydrocortisone Acetate, Methylprednisolone, Metronidazole, Nabumetone, Pantoprazole, Prednisolone, Progesterone, Prednisone, Spironolactone, Sulfasalazine, Tinidazole, Fluoxetine.HCl, Misoprostol, Megestrol Acetate, Capecitabine, Chenodiol (Chenodeoxycholic Acid), Clofazimine, Clonazepam, Cortisone Acetate, Dantrolene.Na, Duloxetine, Fludrocortisone Acetate, Iloperidone, Lorazepam, Nilutamide, Nitisinone, Nitrofurantoin, Oxazepam, Paliperidone, Prasugrel, Probenecid, Rifabutin, Sulfamethoxazole, Ursodiol, Omeprazole, Tenatoprazole, Artemisinin, Danazol, Olmesartan medoxomil, Phenazopyridine, Nitrendipine, Racecadrotil, Fenofibrate, Fluphenazine, Telmisartan, Benzbromarone, Oxethazaine, Mefloquine, Quinacrine, Pimozide, Loxapine succinate, Cyclobenzaprine, Ethopropazine, Promethazine, Clemizole and Pyrimethamine.

Said given drug may further be selected from the group consisting of abacavir sulfate, acebutolol, acecainide, alfuzosin, almotriptan, alprenolol, amantadine, aminoglutethimide, amisulpride, anagrelide, anastrozole, antazoline phosphate, apomorphine, artemisinin, atenolol, atorvastatin calcium, azatadine maleate, bambuterol, Benazepril, benzbromarone, benzthiazide, betamethasone acetate, betamethasone valerate, betaxalol, bezafibrate, bicalutamide, biperiden, bisacodyl, bisoprolol fumarate, bromocriptine mesylate, budesonide, bupropion, buramate, buspirone, camylofine dihydrochloride, capecitabine, carbetapentane citrate, carbinoxamine maleate, carisoprodol, Carvedilol, celecoxib, cetirizine, chlormezanone, cimetidine, citalopram hydrobromide, clemastine fumarate, clemizole, clenbuterol, clidinium bromide, clonidine, clopidogrel sulfate, Clozapine, colchicine, cyclobenzaprine, cyclophosphamide, cyproterone acetate, dabigatran etexilate mesylate, danazol, darifenacin hydrobromide, dasatinib, deflazacort, desvenlafaxine succinate, dexamethasone, dextromethorphan hydrobromide, diacetamate, Dicyclomine, diflorasone diacetate, digitoxin, digoxin, diltiazem, diperodon, diphenylpyraline, Dipyridamole, disopyramide phosphate, domperidone, doxazosin mesylate, doxepin, doxylamine succinate, drospirenone, duloxetine, eletriptan hydrobromide, enalapril maleate, Entacapone, ergonovine maleate, ergotamine tartrate, eszopiclone, ethopropazine, ethoxzolamide, ethynodiol diacetate, etodolac, ezetimibe, famciclovir, famprofazone, febuxostat, fenofibrate, fenspiride, fexofenadine, finasteride, fluconazole, fluoxetine, fluphenazine, fluvoxamine maleate, galantamine, gliclazide, glipizide, griseofulvin, guanfacine, haloperidol, hyoscyamine, idebenone, imatinib, indapamide, indomethacin, Irbesartan, irsogladine maleate, isradipine, itraconazole, ketorolac tromethamine, ketotifen fumarate, labetalol, lamotrigine, letrozole, levamisole, levonorgestrel, linagliptin, lofexidine, Loperamide, losartan, lovastatin, loxapine succinate, mebendazole, mebhydrolin naphthalenesulfonate, mefloquine, megestrol acetate, melphalan, memantine, metaxalone, Methocarbamol, methoxsalen, methsuximide, methylphenidate, methysergide maleate, meticrane, metitepine maleate, metoclopramide, metolazone, metoprolol tartrate, mevastatin, mianserin, mifepristone, milnacipran, mycophenolate mofetil, nadolol, nafronyl oxalate, naftopidil, naloxone, naproxen(+), nateglinide, nefazodone, nefopam, neostigmine bromide, nevirapine, nicergoline, nitrendipine, nizatidine, norethindrone acetate, Norgestimate, noscapine, olanzapine, olmesartan medoxomil, omeprazole, orphenadrine citrate, oxaprozin, oxcarbazepine, oxethazaine, oxybutynin chloride, Paclitaxel, paliperidone, pantoprazole, papaverine, paroxetine, penbutolol sulfate, pentoxifylline, pergolide mesylate, pericyazine, perindopril erbumine, phenacetin, Phenazopyridine, phenytoin sodium, pidotimod, pimozide, pitavastatin calcium, Pranoprofen, prazosin, prednisone, pridinol methanesulfonate, primaquine phosphate, Procarbazine, promethazine, pyrimethamine, quetiapine, quinacrine, quinapril, quinine sulfate, racecadotril, ramelteon, ramipril, ranitidine, ranolazine, rebamipide, repaglinide, Reserpine, riluzole, rimantadine, risperidone, ritonavir, rivastigmine tartrate, rizatriptan benzoate, ropinirole, rosiglitazone maleate, rosuvastatin calcium, roxatidine acetate, sertraline, sildenafil citrate, solifenacin succinate, sotalol, spiperone, sulfasalazine, sulfinpyrazone, sulindac, sulpiride, sumatriptan succinate, tacrine, tacrolimus, tadalafil, tamsulosin hydrchloride, tegaserod maleate, telmisartan, tenatoprazole, tenoxicam, terazosin, terbinafine, thiabendazole, thiothixene, tiapride, timolol maleate, tinidazole, Tolazamide, topotecan, trandolapril, tranilast, trazodone, trihexyphenidyl, trimebutine maleate, trimetazidine dihydrochloride, trimethobenzamide, trimipramine maleate, Triprolidine, tropisetron, trospium chloride, valsartan, venlafaxine, verapamil, vilazodone, Vinpocetine, voriconazole, warfarin, zaleplon, zidovudine [azt], ziprasidone mesylate and zolpidem.

In a particular embodiment, in particular when said given drug is selected from the list of drugs above, said drug-metabolizing gene product is selected from the group consisting of the gene products encoded by the nucleic acid sequences listed in Table 2 below, or is a gene product the amino acid sequence of which is at least 90% identical, in particular at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identical to one of the gene products encoded by the nucleic acid sequences listed in Table 2 below.

In a particular embodiment, in particular when said given drug is selected from the list of drugs above, said drug-metabolizing gene product is expressed or secreted by a bacteria selected from the group consisting of the bacteria recited in Table 2 below.

In a particular embodiment, said drug-targeting enzyme is selected from enzymes having oxidation, deamination, isomerization, esterification, condensation, reduction, hydrolysis and/or rearrangement activities. In a particular embodiment, said drug-targeting enzyme is selected from β-glucuronidases, nitroreductases and sulfoxide reductases.

In a particular embodiment, said given drug is dantrolene, clonazepam, and/or nicardipine, and said drug-targeting enzyme is an enzyme having nitro-reduction activity.

In an alternative embodiment, said given drug is risperidone, and said drug-targeting enzyme is an enzyme having hydrolysis activity, in particular an enzyme hydrolysing the isoxazole moiety of risperidone.

In an alternative embodiment, said given drug is sulfasalazine, and said drug-targeting enzyme is an enzyme having azoreduction activity.

In an alternative embodiment, said given drug is digoxin, and said drug-targeting enzyme is cytochrome glycoside reductase, said bacteria expressing said drug-targeting enzyme being preferably Eggerthella lenta.

In an alternative embodiment, said given drug is levodopa (L-DOPA), and said drug-targeting enzyme is tyrosine decarboxylase, preferably expressed by Enterococcus faecalis, Enterococcus faecium and/or Lactobacillus brevis and/or dopamine dehydrolase, preferably expressed by Eggerthella lenta. In a more particular embodiment, said genetic modification in the DNA sequence encoding said tyrosine decarboxylase induces inactivation of said enzyme, enabling preventing decarboxylation, and thereby inactivation, of L-DOPA by said enzyme, in subjects suffering from Parkinson's disease and treated with levodopa.

In another embodiment, said given drug is levodopa (L-DOPA), and said drug-targeting enzyme is DHPAA synthase, preferably expressed by Clostridium sporogenes. In a more particular embodiment, said genetic modification in the DNA sequence encoding DHPAA synthase induces inactivation of said enzyme, enabling preventing deamination of L-DOPA, and thereby transformation of L-DOPA into 3,4-dihydroxyphenylacetaldehyde (DHPAA), and preventing and/or reducing constipation in subjects suffering from Parkinson's disease and treated with levodopa.

In an alternative embodiment, said given drug is gemcitabine, and said drug-targeting enzyme is cytidine deaminase, said bacteria expressing said drug-targeting enzyme being preferably Escherichia coli and/or Gammaproteobacteria.

In an alternative embodiment, said given drug is prontosil, and said drug-targeting enzyme is an enzyme converting prontosil into p-aminobenzenesulfonamide by azo-reduction.

In an alternative embodiment, said given drug is selected from sulfasalazine, ipsalazide and balsalazide, and said drug-targeting enzyme is an enzyme converting said drug into 5-aminosalicylic acid.

In an alternative embodiment, said given drug is a non-steroidal anti-inflammatory drug, and said drug-targeting enzyme is a β-glucuronidase.

In a particular embodiment, said compound is L-DOPA, and said modification of the interaction is a modification in the adsorption of L-DOPA by Helicobacter pylori, typically by modifying bacterial adhesins from H. pylori involved in said adsorption.

In a particular embodiment, said compound is acetaminophen and said modification of the interaction is a modification in the competition between acetaminophen and p-cresol produced by C. difficile, typically by modifying DNA sequences involved in the production and/or secretion of p-cresol by C. difficile.

The present invention thus also concerns a method of treatment of a subject in need thereof, comprising

- administering a drug to said subject, and
- before, simultaneously with, or after said administration of said drug, administering to said subject a vector encoding enzymes or systems for inducing genetic modifications in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,
- wherein the genetic modification of the DNA sequence coding for the drug-targeting enzyme results in a modification of the drug metabolism in the subject;
- wherein genetic modification does not lead to the direct death of the bacteria.

The present invention thus also concerns a pharmaceutical combination comprising a drug and a vector encoding enzymes or systems for inducing genetic modifications in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence, for simultaneous, sequential or separate use in the treatment of a subject.

The invention also concerns a method for increasing the efficacy of a drug treatment in a subject in need thereof, comprising:

- administering a drug to said subject, and
- before, simultaneously with, or after said administration of said drug, administering to said subject a vector encoding enzymes or systems for inducing genetic modifications in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,
- wherein the genetic modification of the DNa sequence coding for the drug-targeting enzyme results in a modification of the drug metabolism in the subject;
- wherein genetic modification does not lead to the direct death of the bacteria.
  
  Lack of Inhibition of Bacterial Growth

Bacteria with the genetic modification can be assessed for any inhibition of bacterial growth by comparison with the same bacteria without the genetic modification either in vitro or in vivo. This is preferably performed by assessing the percentage of bacteria with and without the genetic modification at at least two timepoints and determining that the bacteria with the genetic modification do not have a reduced percentage at the later time point.

Comparison in vitro can be performed by growing the bacteria in solid or liquid culture and determining the percentages of each type of bacteria over time. The percentages can be determined by routine diagnostic procedures including ELISA, PCR, High Resolution Melting, and nucleic acid sequencing.

Comparison in vivo can be performed by collecting samples (e.g., stool or swab) over time and determining the percentages of each type of bacteria over time. The percentages can be determined by routine diagnostic procedures employing immunodetection (e.g. ELISA), nucleic acid amplification (e.g., PCR), High Resolution Melting, and nucleic acid sequencing.

Preferred percentages of bacteria with the genetic modification are at least 70%, 80%, 90%, 95%, 97%, 98%, 99%, 99.9%, 99.99%, and 100%.

Enzymes and Systems for Inducing Modifications

In some embodiments, the genetic modification is made with one or more of the following enzymes and systems.

Cytosine base editors (CBE) and Adenosine base editors (ABE), as described in Rees et al.⁹which is hereby incorporated by reference.

So far there are seven types of DNA base editors described:

- Cytosine Base Editor (CBE) that convert C:G into T:A³²
- Adenine Base Editor (ABE) that convert A:T into G:C³³
- Cytosine Guanine Base Editor (CGBE) that convert C:G into G:C^29,30
- Cytosine Adenine Base Editor (CABE) that convert C:G into A:T³¹
- Adenine Cytosine Base Editor (ACBE) that convert A:T into C:G³⁴
- Adenine Thymine Base Editor (ATBE) that convert A:T into T:A³⁵
- Thymine Adenine Base Editor (TABE) that convert T:A into A:T^36-38

Base editors differ in the base modification enzymes. CBE rely on ssDNA cytidine deaminase among which: APOBEC1, rAPOBEC1, APOBEC1 mutant or evolved version (evoAPOBEC1), and APOBEC homologs (APOBEC3A (eA3A), Anc689), Cytidine deaminase 1 (CDA1), evoCDA1, FERNY, evoFERNY.

ABE rely on deoxyadenosine deaminase activity of a tandem fusion TadA-TadA* where TadA* is an evolved version of TadA, an E. coli tRNA adenosine deaminase enzyme, able to convert adenosine into Inosine on ssDNA. TadA* include TadA-8a-e and TadA-7.10.

Except from base modification enzyme there has been also modifications implemented to base editor to increase editing efficacy, precision and modularity:

- the addition of one or two uracil DNA glycosylase inhibitor domain (UGI) to prevent base excision repair mechanism to revert base edition
- the addition of Mu-GAM that decrease insertion-deletion rate by inhibiting Non-homologous end joining mechanism in the cell (NHEJ)
- the use of nickase active Cas9 (nCas9 D10A) that, by creating nicks on the non-edited strand favors its repair and consequently the fixation of the edited base.
- the use of diverse Cas proteins from for example different organisms, mutants with different PAM motifs or different fidelity or different family (e.g. Cas12a).

Non-limiting examples of DNA-based editor proteins include BE1, BE2, BE3, BE4, BE4-GAM, HF-BE3, Sniper-BE3, Target-AID, Target-AID-NG, ABE, EE-BE3, YE1-BE3, YE2-BE3, YEE-BE3, BE-PLUS, SaBE3, SaBE4, SaBE4-GAM, Sa(KKH)-BE3, VQR-BE3, VRER-BE3, EQR-BE3, xBE3, Cas12a-BE, Ea3A-BE3, A3A-BE3, TAM, CRISPR-X, ABE7.9, ABE7.10, ABE7.10*, xABE, ABESa, VQR-ABE, VRER-ABE, Sa(KKH)-ABE, ABE8e, SpRY-ABE, SpRY-CBE, SpG-CBE4, SpG-ABE, SpRY-CBE4, SpCas9-NG-ABE, SpCas9-NG-CBE4, enAsBE1.1, enAsBE1.2, enAsBE1.3, enAsBE1.4, AsBE1.1, AsBE1.4, CRISPR-Abest, CRISPR-Cbest, eA3A-BE3, AncBE4.

Cytosine Guanine Base Editors (CGBE) consist of a nickase CRISPR fused to:

- a. A cytosine deaminase (rAPOBEC) and base excision repair proteins (e.g. rXRCC1).^29,41
- b. A rat APOBEC1 variant (R33A) protein and an E. coli-derived uracil DNA N-glycosylase (eUNG).³⁰

Cytosine Adenine Base Editors (CABE) consist of a Cas9 nickase, a cytidine deaminase (e.g. AID), and a uracil-DNA glycosylase (Ung).³¹

ACBE include a nucleic acid programmable DNA-binding protein and an adenine oxidase.34

ATBE consist of a Cas9 nickase and one or more adenosine deaminase or an oxidase domain.³⁵

TABE consist of a Cas9 nickase and an adenosine methyltransferase, a thymine alkyltransferase, or an adenosine deaminase domain.^36-38

Base editor molecules can also consist of two or more of the above listed editor enzymes fused to a Cas protein (e.g. combination of an ABE and CBE). These biomolecules are named dual base editors and enable the editing of two different bases.^39,40

In a particular embodiment, the genetic modification is made with a Cytosine base editor (CBE) and/or an Adenosine base editor (ABE) as defined above.

Prime editors (PE), as described in Anzalone et al.¹⁰which is hereby incorporated by reference, consist of a nCas9 fused to a reverse transcriptase used in combination with a prime editing RNA (pegRNA; a guide RNA that includes a template region for reverse transcription).

Prime Editing allows introduction of insertions, deletions (indels), and 12 base-to-base conversions. Prime editing relies on the ability of a reverse transcriptase (RT), fused to a Cas nickase variant, to convert RNA sequence brought by a prime editing guide RNA (pegRNA) into DNA at the nick site generated by the Cas protein. The DNA flap generated from this process is then included or not in the targeted DNA sequence.

Prime editing systems include:

- a Cas nickase variant such as Cas9-H840A fused to a reverse transcriptase domain such as M-MLV RT or its mutant version (M-MLV RT(D200N), M-MLV RT(D200N/L603W), M-MLV RT(D200N/L603W/T330P/T306K/W313F)
- a prime editing guide RNA (pegRNA)

To favor editing, the prime editing system can include the expression of an additional sgRNA targeting the Cas nickase activity towards the non-edited DNA strand ideally only after the resolution of the edited strand flap by designing the sgRNA to anneal with the edited strand but not with the original strand.

Non-limiting examples of prime editing systems include PE1, PE1-M1, PE1-M2, PE1-M3, PE1-M6, PE1-M15, PE1-M3inv, PE2, PE3, PE3b.

Cas9 Retron preciSe Parallel Editing via homologY (‘CRISPEY’), a retron RNA fused to the sgRNA and expressed together with Cas9 and the retron proteins including at least the reverse transcriptase¹¹.

The SCRIBE strategy: a retron system expressed in combination with a recombinase promoting the recombination of single stranded DNA, also known as single stranded annealing proteins (SSAPs)¹². Such recombinases include but are not limited to phage recombinases such as lambda red, recET, Sak, Sak4, and newly described SSAPs described in Wannier et al¹³which is hereby incorporated by reference.

The targetron system based on group II introns described in Karberg et al.¹⁴, which is hereby incorporated by reference, and which has been adapted to many bacterial species.

Other retron based gene targeting approaches are described in Simon et al.¹⁵which is hereby incorporated by reference.

CRISPR-Cas. The CRISPR system contains two distinct elements, i.e. i) an endonuclease, in this case the CRISPR associated nuclease (Cas or “CRISPR associated protein”) and ii) a guide RNA. Depending on the type of CRISPR system, the guide RNA may be in the form of a chimeric RNA which consists of the combination of a CRISPR (crRNA) bacterial RNA and a tracrRNA (trans-activating RNA CRISPR)¹⁶. The guide RNA combines the targeting specificity of the crRNA corresponding to the “spacing sequences” that serve as guides to the Cas proteins, and the conformational properties of the tracrRNA in a single transcript. When the guide RNA and the Cas protein are expressed simultaneously in the cell, the target genomic sequence can be permanently interrupted (and causing disappearance of the targeted and surrounding sequences and/or cell death, depending on the location) or modified. The modification may be guided by a repair matrix.

The CRISPR system includes two main classes depending on the nuclease mechanism of action:

- Class 1 is made of multi-subunit effector complexes and includes type I, Ill and IV
- Class 2 is made of single-unit effector modules, like Cas9 nuclease, and includes type II (II-A, II-B, II-C, II-C variant), V (V-A, V-B, V-C, V-D, V-E, V-U1, V-U2, V-U3, V-U4, V-U5) and VI (VI-A, VI-B1, VI-B2, VI-C, VI-D)

The sequence of interest according to the present invention preferably comprises a nucleic acid sequence encoding Cas protein. A variety of CRISPR enzymes are available for use as a sequence of interest on the vector according to the present invention. In some embodiments, the CRISPR enzyme is a Type II CRISPR enzyme, a Type II-A or Type II-B CRISPR enzyme. In another embodiment, the CRISPR enzyme is a Type I CRISPR enzyme or a Type III CRISPR enzyme. In some embodiments, the CRISPR enzyme catalyzes DNA modification. In some other embodiments, the CRISPR enzyme catalyzes RNA modification. For instance, Cas13-deaminase fusions have been used for RNA base editing thus modifying RNA¹⁷. In one embodiment, the CRISPR enzymes may be coupled to a guide RNA or single guide RNA (sgRNA). In certain embodiments, the guide RNA or sgRNA targets a DNA sequence or gene selected from the group consisting of an antibiotic resistance gene, virulence protein or factor gene, toxin protein or factor gene, a bacterial receptor gene, a membrane protein gene, a structural protein gene, a secreted protein gene, a gene expressing resistance to a drug in general and a gene causing a deleterious effect to the host. Preferably, the CRISPR enzyme does not make a double strand break. In some embodiments, the CRISPR enzyme makes a single strand break or nicks. In some embodiments, the CRISPR enzyme does not make any break in the DNA or RNA. In one embodiment, a Cas13-deaminase fusion is used to base edit an RNA.

The sequence of interest may comprise a nucleic acid sequence encoding a guide RNA or sgRNA to guide the Cas protein endogenous to the targeted bacteria, alone or in combination with a Cas protein and/or a guide RNA encoded by the vector.

Non-limiting examples of Cas proteins as part of a multi-subunit effector or as a single-unit effector include Cas1, Cas1B, Cas2, Cas3, Cas4, Cas5, Cas6, Cas7, Cas8, Cas9 (also known as Csn1 and Csx12), Cas10, Cas11 (SS), Cas12a (Cpf1), Cas12b (C2c1), Cas12c (C2c3), Cas12d (CasY), Cas12e (CasX), C2c4, C2c8, C2c5, C2c10, C2c9, Cas13a (C2c2), Cas13b (C2c6), Cas13c (C2c7), Cas13d, Csa5, Csc1, Csc2, Cse1, Cse2, Csy1, Csy2, Csy3, Csf1, Csf2, Csf3, Csf4, Csm1, Csm2, Csm3, Csm4, Csm5, Csm6, Cmr1, Cmr3, Cmr4, Cmr5, Cmr6, Csn2, Csb1, Csb2, Csb3, Csx17, Csx14, Csx10, Csx16, CsaX, Csx13, Csx1, Csx15, SdCpf1, CmtCpf1, TsCpf1, CmaCpf1, PcCpf1, ErCpf1, FbCpf1, UbcCpf1, AsCpf1, LbCpf1, homologues thereof, orthologues thereof, variants thereof, or modified versions thereof. In some embodiments, the CRISPR enzyme cleaves both strands of the target nucleic acid at the Protospacer Adjacent Motif (PAM) site.

In various embodiments, the nucleic acid of interest encodes fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and a deaminase domain. In some embodiments, the fusion protein comprises Cas9 and a cytosine deaminase enzyme, such as APOBEC enzymes, or adenosine deaminase enzymes, such as ADAT enzymes, for example as disclosed in U.S. Patent Publ. 2015/0166980, which is hereby incorporated by reference. In one embodiment, the deaminase is an ACF1/ASE deaminase.

In various embodiments, the APOBEC deaminase is selected from the group consisting of APOBEC1 deaminase, APOBEC2 deaminase, APOBEC3A deaminase, APOBEC3B deaminase, APOBEC3C deaminase, APOBEC3D deaminase, APOBEC3F deaminase, APOBEC3G deaminase, and APOBEC3H deaminase. In various embodiments, the fusion protein comprises a Cas9 domain, a cytosine deaminase domain, and a uracil glycosylase inhibitor (UGI) domain.

In one embodiment, the deaminase is an adenosine deaminase that deaminate adenosine in DNA, for example as disclosed in U.S. Pat. No. 10,113,163, which is hereby incorporated by reference. In some embodiments, the fusion proteins further comprise an inhibitor of base repair, such as, a nuclease dead inosine specific nuclease (dISN), for example as disclosed in U.S. Pat. No. 10,113,163. In various embodiments, the nucleic acid of interest encodes fusion proteins comprising a catalytically impaired Cas9 endonuclease fused to an engineered reverse transcriptase, programmed with a prime editing guide RNA (pegRNA) that both specifies the target site and encodes the desired edit, for example as described in Anzalone et al.¹⁰, which is hereby incorporated by reference.

In a particular embodiment, the CRISPR enzyme is any Cas9 protein, for instance any naturally-occurring bacterial Cas9 as well as any variants, homologs or orthologs thereof.

By “Cas9” is meant a protein Cas9 (also called Csn1 or Csx12) or a functional protein, peptide or polypeptide fragment thereof, i.e. capable of interacting with the guide RNA(s) and of exerting the enzymatic activity (nuclease) which allows it to perform the double-strand cleavage of the DNA of the target genome. “Cas9” can thus denote a modified protein, for example truncated to remove domains of the protein that are not essential for the predefined functions of the protein, in particular the domains that are not necessary for interaction with the gRNA (s). Preferably, the Cas9 is a dCas9 (dead-Cas9) or nCas9 (nickase Cas9) lacking double strand DNA cleavage activity.

The sequence encoding Cas9 (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cas9 protein^18-20. Examples of Cas9 proteins useful in the present invention include, but are not limited to, Cas9 proteins of Streptococcus pyogenes (SpCas9), Streptococcus thermophiles (St1Cas9, St3Cas9), Streptococcus mutans, Staphylococcus aureus (SaCas9), Campylobacter jejuni (CjCas9), Francisella novicida (FnCas9) and Neisseria meningitides (NmCas9).

The sequence encoding Cpf1 (Cas12a) (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cpf1 (Cas12a) protein^18,19. Examples of Cpf1(Cas12a) proteins useful in the present invention include, but are not limited to, Cpf1(Cas12a) proteins of Acidaminococcus sp, Lachnospiraceae bacteriu and Francisella novicida.

The sequence encoding Cas13a (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cas13a (C2c2) protein²¹. Examples of Cas13a (C2c2) proteins useful in the present invention include, but are not limited to, Cas13a (C2c2) proteins of Leptotrichia wadei (LwaCas13a).

The sequence encoding Cas13d (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cas13d protein (Yan et al. (2018) Mol Cell 70(2):327-339).Examples of Cas13d proteins useful in the present invention include, but are not limited to, Cas13d proteins of Eubacterium siraeum and Ruminococcus sp.

In some embodiments, other programmable nucleases can be used. These include an engineered TALEN (Transcription Activator-Like Effector Nuclease) and variants, engineered zinc finger nuclease (ZFN) variants, natural, evolved or engineered meganuclease or recombinase variants, and any combination or hybrids of programmable nucleases. Thus, the programmable nucleases provided herein may be used to selectively modify DNA encoding a DNA sequence or gene of interest such as, for example, a toxin gene, a virulence factor gene, an antibiotic resistance gene, a remodeling gene or a modulatory gene (cf. WO2014124226 and US2015/0064138).

In some embodiments, the genetic modification is made at the RNA level. RNA base editing is based on the same principle as DNA base editing: an enzyme catalyzing the conversion of a RNA base into another must be brought close to the target base to perform its conversion locally. In one embodiment, the enzyme used for RNA editing is an adenosine deaminase from ADAR family that converts Adenosine into Inosine in dsRNA structure. Several seminal studies used this specificity for dsRNA and fused the ADAR deaminase domain (ADAR_DD) to an antisense oligo in order to program local RNA base editing. More recently the ability of some CRISPR-Cas systems to bind RNA molecules was repurposed into RNA editing. Using catalytically dead Cas13b enzyme (dPspCas13b) fused to a hyperactive mutant of ADAR2 deaminase domain (ADAR2_DD-E488Q for REPAIRv1 and ADAR2_DD-E488Q-T375G for REPAIRv2) Cox et al improved specificity and efficiency compare to previous RNA editing strategies.

Non-limiting examples of RNA based editor proteins include REPAIRv1, REPAIRv2.

Vectors for Inducing Modifications

In various embodiments, one or more of the following vectors can be used to introduce the exogenous enzyme that results in a genetic modification:

- Engineered phages
- Engineered bacteria
- Plasmid (e.g., a conjugative plasmid capable of transfer into a host cell), phage, phagemid or prophage.
- Each vector may be as described above, eg, a phage capable of infecting a host cell or conjugative plasmid capable of introduction into a host cell, which can be introduced either by a phage particle (engineered or wild-type phage) via injection or by a donor bacteria via conjugation. In an example, the vectors are in combination with an antibiotic agent (e.g., a beta-lactam antibiotic) and/or with any other agent.
- A bacteriophage for modifying a naturally occurring bacteria in situ comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the genome of said target bacteria, but does not lead to the death of the target bacteria.

The invention encompasses the use of these vectors wherein the gene editing enzyme/system targets a DNA sequence or gene within the target bacteria encoding a protein which is directly or indirectly responsible for a disease or disorder.

In a particular embodiment, said vector does not replicate in the targeted bacteria.

Origin of Replication

In preferred embodiments the DNA in the vector will comprise an origin of replication for the targeted bacteria. Origins of replication known in the art have been identified from species-specific plasmid DNAs (e.g. ColE1, RI, pT181, pSC101, pMB1, R6K, RK2, p15a and the like), from bacterial virus (e.g. φX174, M13, F1 and P4) and from bacterial chromosomal origins of replication (e.g. oriC).

In one embodiment, the vector according to the invention comprises a bacterial origin of replication that is functional in the targeted bacteria.

Alternatively, the vector according to the invention does not comprise any functional bacterial origin of replication or contain an origin of replication that is inactive in the targeted bacteria. Thus, the vector of the invention cannot replicate by itself once it has been introduced into a bacterium by the bacterial virus particle.

In one embodiment, the origin of replication on the vector to be packaged is inactive in the targeted bacteria, meaning that this origin of replication is not functional in the bacteria targeted by the bacterial virus particles, thus preventing unwanted vector replication.

In one embodiment, the vector comprises a bacterial origin of replication that is functional in the bacteria used for the production of the bacterial virus particles.

Bacteria-Specific Origins of Replication

Plasmid replication depends on host enzymes and on plasmid-controlled cis and trans determinants. For example, some plasmids have determinants that are recognized in almost all gram-negative bacteria and act correctly in each host during replication initiation and regulation. Other plasmids possess this ability only in some bacteria (Kues, U and Stahl, U 1989 Microbiol Rev 53:491-516).

Plasmids are replicated by three general mechanisms, namely theta type, strand displacement, and rolling circle (reviewed by Del Solar et al. 1998 Microhio and Molec Biol. Rev 62:434-464) that start at the origin of replication. This replication origins contain sites that are required for interactions of plasmid and/or host encoded proteins.

Origins of replication used on the vector of this invention may be moderate copy number, such as ColE1 ori from pBR322 (15-20 copies per cell) or the R6K plasmid (15-20 copies per cell) or may be high copy number, e.g. pUC oris (500-700 copies per cell), pGEM oris (300-400 copies per cell), pTZ oris (>1000 copies per cell) or pBluescript oris (300-500 copies per cell).

In one embodiment, the bacterial origin of replication is selected in the group consisting of ColE1, pMB1 and variants (pBR322, pET, pUC, etc), p15a, ColA, ColE2, pOSAK, pSC101, R6K, IncW (pSa etc), IncFII, pT181, P1, F IncP, IncC, IncJ, IncN, IncP1, IncP4, IncQ, IncH11, RSF1010, CloDF13, NTP16, R1, f5, pPS10, pC194, pE194, BBR1, pBC1, pEP2, pWVO1, pLF1311, pAP1, pWKS1, pLS1, pLS11, pUB6060, pJD4, pIJ101, pSN22, pAMbeta1, pIP501, pIP407, ZM6100(Sa), pCU1, RA3, pMOL98, RK2/RP4/RP1/R68, pB10, R300B, pRO1614, pRO1600, pECB2, pCM1, pFA3, RepFIA, RepFIB, RepFIC, pYVE439-80, R387, phasyl, RA1, TF-FC2, pMV158 and pUB113.

More preferably, the bacterial origin of replication is an E. coli origin of replication selected in the group consisting of ColE1, pMB1 and variants (pBR322, pET, pUC, etc), p15a, ColA, ColE2, pOSAK, pSC101, R6K, IncW (pSa etc), IncFII, pT181, P1, F IncP, IncC, IncJ, IncN, IncP1, IncP4, IncQ, IncH11, RSF1010, CloDF13, NTP16, R1, f5, pPS10.

More preferably, the bacterial origin of replication is selected in the group consisting of pC194, pE194, BBR1, pBC1, pEP2, pWVO1, pLF1311, pAP1, pWKS1, pLS1, pLS11, pUB6060, pJD4, pIJ101, pSN22, pAMbeta1, pIP501, pIP407, ZM6100(Sa), pCU1, RA3, pMOL98, RK2/RP4/RP1/R68, pB10, R300B, pRO1614, pRO1600, pECB2, pCM1, pFA3, RepFIA, RepFIB, RepFIC, pYVE439-80, R387, phasyl, RA1, TF-FC2, pMV158 and pUB113.

Even more preferably, the bacterial origins of replication are ColE1 and p15a.

In one embodiment, the bacterial origin of replication is functional in Propionibacterium and Cutibacterium more specifically in Propionibacterium freudenreichii and Cutibacterium acnes and is selected from the group consisting of pLME108, pLME106, p545, pRGO1, pZGX01, pPG01, pYS1, FRJS12-3, FRJS25-1, pIMPLE-HL096PA1,A_15_1_R1.

Phage Origin of Replication

The vector according to the invention may comprise a phage replication origin which can initiate, with complementation in cis or in trans of a complete or modified phage genome, the replication of the payload for later encapsulation into the different capsids.

The phage origin can also be engineered to act as a bacterial origin of replication without the need to package any phage particles.

A phage origin of replication comprised in the payload of the invention can be any origin of replication found in a phage.

Preferably, the phage origin of replication can be the wild-type or non-wildtype sequence of the M13, f1, φX174, P4, Lambda, P2, 186, Lambda-like, HK022, mEP237, HK97, HK629, HK630, mEP043, mEP213, mEP234, mEP390, mEP460, mEPx1, mEPx2, phi80, mEP234, T2, T4, T5, T7, RB49, phiX174, R17, PRD1 PI-like, P2-like, P22, P22-like, N15 and N15-like bacteriophages.

More preferably, the phage origin of replication is selected in the group consisting of phage origins of replication of M13, f1, φX174, P4, and Lambda.

In a particular embodiment, the phage origin of replication is the P4 origin of replication.

In a particular embodiment, the phage origin of replication is from Propionibacterium phages: BW-like phages such as Doucette, B22, E6, G4, BV-like phages such as Anatole, E1, B3, BX-like phages such as PFR1 and PFR2, filamentous B5 phage, BU-like phages (Cutibacterium acnes phages).

Conditional Origin of Replication

In a particular embodiment, the vector comprises a conditional origin of replication which is inactive in the targeted bacteria but is active in a donor bacterial cell.

In the context of the invention, a “conditional origin of replication” refers to an origin of replication whose functionality may be controlled by the presence of a specific molecule.

In a particular embodiment, the conditional origin of replication is an origin of replication, the replication of which depends upon the presence of one or more given protein, peptid, RNA, nucleic acid, molecule or any combination thereof.

In a particular embodiment, the replication of said origin of replication may further depend on a process, such as transcription, to activate said replication.

In the context of the invention, said conditional origin of replication is inactive in the targeted bacteria because of the absence of said given protein, peptid, RNA, nucleic acid, molecule or any combination thereof in said targeted bacteria.

In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, RNA, nucleic acid, molecule or any combination thereof. In a particular embodiment, said protein, peptid, RNA nucleic acid, molecule or any combination thereof is expressed in trans in said donor bacterial cell.

By “in trans” is meant herein that said protein, peptid, RNA, nucleic acid, molecule or any combination thereof is not encoded on the same nucleic acid molecule as the one comprising the origin of replication. In a particular embodiment, said protein, peptid, RNA, nucleic acid, molecule or any combination thereof is encoded on a chromosome or on a vector, in particular a plasmid. In a particular embodiment, said vector comprises an antibiotic resistance marker. In an alternative embodiment, said vector is devoid of antibiotic resistance marker.

Since said conditional origin of replication is inactive in the targeted bacteria because of the absence of said given protein, peptid, RNA, nucleic acid, molecule or any combination thereof in said targeted bacteria, said conditional origin of replication may be selected depending on the specific bacteria to be targeted.

The conditional origin of replication disclosed herein may originate from plasmids, bacteriophages or PICIs which preferably share the following characteristics: they contain in their origin of replication repeat sequences, or iterons, and they code for at least one protein interacting with said origin of replication (i.e. Rep, protein O, protein P, pri) which is specific to them.

By way of example, mention may be made of the conditional replication systems of the following plasmids and bacteriophages: RK2, R1, pSC101, F, Rts1, RSF1010, P1, P4, lambda, phi82, phi80.

In a particular embodiment, said conditional origin of replication is selected from the group consisting of the R6KA DNA replication origin and derivatives thereof, the IncPα oriV origin of replication and derivatives thereof, ColE1 origins of replication modified to be under an inducible promoter, and origins of replication from phage-inducible chromosomal islands (PICIs) and derivatives thereof.

In a particular embodiment, said conditional origin of replication is an origin of replication present in less than 50%, or less than 40%, less than 30%, less than 20%, less than 10% or less than 5% of the bacteria of the host microbiome.

In another particular embodiment, said conditional origin of replication comprises or consists of a sequence less than 80% identical, in particular less than 70%, less than 60%, less than 50%, less than 40%, less than 30%, less than 20%, less than 10%, less than 5% or less than 1% identical to the sequences of the origins of replication of the bacteria of the host microbiome, in particular of the bacteria representing more than 50%, more particularly more than 60%, more than 70%, more than 80%, more than 90% or more than 95% of the host microbiome.

As used herein, the term “phage-inducible chromosomal islands” or “PICIs” refers to mobile genetic elements having a conserved gene organization, and encode a pair of divergent regulatory genes, including a PICI master repressor. Typically, in Gram-positive bacteria, left of rpr, and transcribed in the same direction, PICIs encode a small set of genes including an integrase (int) gene; right of rpr, and transcribed in the opposite direction, the PICIs encode an excision function (xis), and a replication module consisting of a primase homolog (pri) and optionally a replication initiator (rep), which are sometimes fused, followed by a replication origin (ori), next to these genes, and also transcribed in the same direction, PICIs encode genes involved in phage interference, and optionally, a terminase small subunit homolog (terS).

In a particular embodiment, said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs).

A particular conditional origin of replication has indeed been derived from PICIs.

It was shown that it is possible to derive novel conditionally replicative vectors, in particular based on the primase-helicase and origin of replication from PICIs. These origins may be relatively rare in target strains, and more advantageously the primase-ori pair may be unique for each PICI, significantly reducing the possibility of undesired recombination or payload spread events. They can further be modified to further limit recombination chances and remove restriction sites to bypass target bacteria defense systems.

In a particular embodiment, said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073, disclosed in Fillol-Salom et al. (2018) The ISME Journal 12:2114-2128.

In a particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073, typically of sequence SEQ ID NO: 12.

In another particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073, devoid of at least 1, at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15 or at least 16 restriction site(s) selected from the group consisting of GAAABCC, GCCGGC, RCCGGY, GCNGC, TWCANNNNNNTGG (SEQ ID NO: 13), TGGCCA, ACCYAC, YGGCCR, AGACC, GCWGC, GGGANGC, GKAGATD, GCCGGYYD, GGCYAC, RGCCGGYYD, and VGCCGGYBD.

In a particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073, devoid of the restriction site GAAABCC. Preferably, said conditional origin of replication is of sequence SEQ ID NO: 7.

In another particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073 devoid of the restriction sites GAAABCC, GCCGGC, RCCGGY, GCNGC, TWCANNNNNNTGG (SEQ ID NO: 13), TGGCCA, ACCYAC, YGGCCR, AGACC, GCWGC, GGGANGC, GKAGATD, GCCGGYYD, GGCYAC, RGCCGGYYD, and VGCCGGYBD. Preferably, said conditional origin of replication is of sequence SEQ ID NO: 8.

In a particular embodiment, wherein said origin of replication is derived from phage-inducible chromosomal islands (PICIs), said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase, in particular a primase-helicase of sequence SEQ ID NO: 14, typically encoded by a nucleic acid comprising or consisting of the sequence SEQ ID NO: 15.

It was demonstrated that these specific conditional origins of replication were particularly compatible with lambda-based packaging, leading to sufficiently high titers (>10¹⁰/mL) required for microbiota-related applications.

In a particular embodiment, when said vector is a phagemid, said origin of replication may be derived from a microorganism which is different from the one that is used to encode the structural elements of the capsid packaging said phagemid.

By “donor bacterial cell” is meant herein a bacterium that is capable of hosting a vector as defined above, of producing a vector as defined above and/or which is capable of transferring said vector as defined above to another bacterium. In a particular embodiment, said vector may be a phagemid, and said donor bacterial cell may then be a bacterial cell able to produce said phagemid, more particularly in the form of a packaged phagemid. In an alternative embodiment, said vector may be a plasmid, more particularly a conjugative plasmid, and said donor bacterial cell may then be a bacterium that is capable of transferring said conjugative plasmid to another bacterium, in particular by conjugation.

Preferably, said donor bacterial cell stably comprises said vector and is able to replicate said vector.

In a particular embodiment, when the conditional origin of replication of said vector is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof, said donor bacterial cell expresses said protein, peptid, nucleic acid, RNA, molecule or any combination thereof. Preferably, said protein, peptid, nucleic acid, RNA, molecule or any combination thereof is expressed in trans, as defined above.

In a particular embodiment, said donor bacterial cell stably comprises a nucleic acid encoding said protein, peptid, nucleic acid, RNA, molecule or any combination thereof.

In a particular embodiment, when said origin of replication is derived from phage-inducible chromosomal islands (PICIs), said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase, in particular a primase-helicase of sequence SEQ ID NO: 14.

In a particular embodiment, said donor bacterial cell stably comprises a nucleic acid encoding said rep protein, in particular said primase-helicase, said nucleic acid typically comprising or consisting of the sequence SEQ ID NO: 15.

In a particular embodiment, said donor bacterial cell is a production cell line, in particular a cell line producing packaged phagemids including the vector of the invention.

Generation of packaged phagemids and bacteriophage particles by production cell lines are routine techniques well-known to one skilled in the art. In an embodiment, a satellite phage and/or helper phage may be used to promote the packaging of the vector in the delivery vehicles disclosed herein. Helper phages provide functions in trans and are well known to the man skilled in the art. The helper phage comprises all the genes coding for the structural and functional proteins that are indispensable for the phagemid to be packaged, (i.e. the helper phage provides all the necessary gene products for the assembly of the delivery vehicle). The helper phage may contain a defective origin of replication or packaging signal, or completely lack the latter, and hence it is incapable of self-packaging, thus only bacterial delivery particles carrying the vector or plasmid will be produced. Helper phages may be chosen so that they cannot induce lysis of the bacterial cells used for the delivery particle production. One skilled in the art would understand that some bacteriophages are defective and need a helper phage for payload packaging. Thus, depending on the bacteriophage chosen to prepare the bacterial delivery particles, the person skilled in the art would know if a helper phage is required. Sequences coding for one or more proteins or regulatory processes necessary for the assembly or production of packaged payloads may be supplied in trans. For example, STF, gpJ and gpH proteins may be provided in a vector or plasmid under the control of an inducible promoter or expressed constitutively. In this case, the phage wild-type sequence may or not contain a deletion of the gene or sequence supplied in trans. Additionally, chimeric or modified phage sequences encoding a new function, like an engineered STF, gpJ or gpH protein, may be directly inserted into the desired position in the genome of the helper phage, hence bypassing the necessity of providing the modified sequence in trans. Methods for both supplying a sequence or protein in trans in the form of a vector or plasmid, as well as methods to generate direct genomic insertions, modifications and mutations are well known to those skilled in the art.

Delivery Vehicle Incapable of Self-Reproduction

In a particular embodiment, the delivery vehicle, in particular the bacteriophage, bacterial virus particle or packaged phagemid, comprising the vector of the invention is incapable of self-reproduction.

In the context of the present invention, “self-reproduction” is different from “self-replication”, “self-replication” referring to the capability of replicating a nucleic acid, whereas “self-reproduction” refers to the capability of having a progeny, in particular of producing new delivery vehicles, said delivery vehicles being either produced empty or with a nucleic acid of interest packaged.

By “delivery vehicle incapable of self-reproduction” is meant herein that at least one, several or all functional gene(s) necessary to produce said delivery vehicle is(are) absent from said delivery vehicle (and from said vector included in said delivery vehicle). In a preferred embodiment, said at least one, several or all functional gene(s) necessary to produce said delivery vehicle is(are) present in the donor cell as defined above, preferably in a plasmid, in the chromosome or in a helper phage present in the donor cell as defined above, enabling the production of said delivery vehicle in said donor cell.

In the context of the invention, said functional gene necessary to produce delivery vehicle may be absent through (i) the absence of the corresponding gene or (ii) the presence of the corresponding gene but in a non-functional form.

In an embodiment, the sequence of said gene necessary to produce said delivery vehicle is absent from said delivery vehicle. In a preferred embodiment, the sequence of said gene necessary to produce said delivery vehicle has been replaced by a nucleic acid sequence of interest, in particular by a nucleic acid sequence encoding enzymes or systems for inducing genetic modifications, as defined above.

Alternatively, said gene necessary to produce said delivery vehicle is present in said delivery vehicle in a non-functional form, for example in a mutant non-functional form, or in a non-expressible form, for example with deleted or mutated non-functional regulators. In a preferred embodiment, said gene necessary to produce said delivery vehicle is present in said delivery vehicle in a mutated form which renders it non-functional in the target cell, while remaining functional in the donor cell.

In the context of the invention, genes necessary to produce said delivery vehicle encompass any coding or non-coding nucleic acid required for the production of said delivery vehicle.

Examples of genes necessary to produce said delivery vehicle include genes encoding phage structural proteins; phage genes involved in the control of genetic expression; phage genes involved in transcription and/or translation regulation; phage genes involved in phage DNA replication; phage genes involved in production of phage proteins; phage genes involved in phage proteins folding; phage genes involved in phage DNA packaging; and phage genes encoding proteins involved in bacterial cell lysis.

Sequence of Interest Under the Control of the Promoter

The vector can comprise a sequence of interest under the control of at least one promoter.

In one embodiment, the sequence of interest is a programmable nuclease circuit to be delivered to the targeted bacteria. This programmable nuclease circuit may be able to mediate in vivo sequence-specific elimination of bacteria that contain a target gene of interest (e.g. a gene that is harmful to humans). Some embodiments of the present disclosure relate to engineered variants of the Type II CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated) system of Streptococcus pyogenes. Other programmable nucleases that can be used include other CRISPR-Cas systems, engineered TALEN (Transcription Activator-Like Effector Nuclease) variants, engineered zinc finger nuclease (ZFN) variants, natural, evolved or engineered meganuclease or recombinase variants, and any combination or hybrids of programmable nucleases. Thus, the engineered autonomously distributed circuits provided herein may be used to selectively modify DNA encoding a gene of interest such as, for example, a toxin gene, a virulence factor gene, an antibiotic resistance gene, a remodeling gene or a modulatory gene (cf. WO2014124226 and US2015/0064138).

Other sequences of interest, preferably programmable, can be added to the vector so as to be delivered to targeted bacteria.

Preferably, the sequence of interest circuit added to the payload does not lead to bacteria death. For example, the sequence of interest may encode reporter genes leading to a luminescence or fluorescence signal. Alternatively, the sequence of interest may comprise proteins and enzymes achieving a useful function such as modifying the metabolism of the bacteria, the composition of its environment or affecting the host. More specifically the sequence of interest might be an antigen triggering a host immune response. The specific antigen can be released in the environment after induction of the lysis of the target cell or can be secreted by the target cell, for example, as described in Costa et al²²and Anné et al²³.

In a particular embodiment, the nucleic acid sequence of interest is selected from the group consisting of a Cas nuclease, a Cas9 nuclease, a guide RNA, a single guide RNA (sgRNA), a CRISPR locus, a gene expressing an enzyme such as a nuclease or a kinase, a TALEN, a ZFN, a meganuclease, a recombinase, a bacterial receptor, a membrane protein, a structural protein, a secreted protein, a gene expressing resistance to an antibiotic or to a drug in general, a gene expressing a toxic protein or a toxic factor and a gene expressing a virulence protein or a virulence factor, a bacterial secretory protein or transporter, a bacterial pore or any of their combination. These proteins can also be modified or engineered to include extra features, like the addition or removal of a function (e.g. dCas9), the addition of a secretion signal to a protein not normally secreted, the addition of an exogenous peptide in a loop as non-limiting examples.

Targeted Bacteria

The bacteria targeted by the vectors, delivery particles, bacteriophages, donor cells, bacterial virus particles or packaged phagemids can be any bacteria present in a mammal organism, a plant or in the environment. It can be any commensal, symbiotic or pathogenic bacteria of the microbiota or microbiome.

A microbiome may comprise a variety of endogenous bacterial species, any of which may be targeted in accordance with the present disclosure. In some embodiments, the genus and/or species of targeted endogenous bacterial cells may depend on the type of bacteriophages being used for preparing the bacterial virus particles. For example, some bacteriophages exhibit tropism for, or preferentially target, specific host species of bacteria. Other bacteriophages do not exhibit such tropism and may be used to target a number of different genus and/or species of endogenous bacterial cells.

Examples of bacterial cells include, without limitation, cells from bacteria of the genus Yersinia spp., Escherichia spp., Klebsiella spp., Acinetobacter spp., Bordetella spp., Neisseria spp., Aeromonas spp., Franciesella spp., Corynebacterium spp., Citrobacter spp., Chlamydia spp., Hemophilus spp., Brucella spp., Mycobacterium spp., Legionella spp., Rhodococcus spp., Pseudomonas spp., Helicobacter spp., Vibrio spp., Bacillus spp., Erysipelothrix spp., Salmonella spp., Streptomyces spp., Streptococcus spp., Staphylococcus spp., Bacteroides spp., Prevotella spp., Clostridium spp., Bifidobacterium spp., Clostridium spp., Brevibacterium spp., Lactococcus spp., Leuconostoc spp., Actinobacillus spp., Selnomonas spp., Shigella spp., Zymonas spp., Mycoplasma spp., Treponema spp., Leuconostoc spp., Corynebacterium spp., Enterococcus spp., Enterobacter spp., Pyrococcus spp., Serratia spp., Morganella spp., Parvimonas spp., Fusobacterium spp., Actinomyces spp., Porphyromonas spp., Micrococcus spp., Bartonella spp., Borrelia spp., Brucelia spp., Campylobacter spp., Chlamydophilia spp., Cutibacterium spp., Propionibacterium spp., Gardnerella spp., Ehrlichia spp., Haemophilus spp., Leptospira spp., Listeria spp., Mycoplasma spp., Nocardia spp., Rickettsia spp., Ureaplasma spp., Lactobacillus spp. and a mixture thereof.

Thus, vectors, delivery particles, bacteriophages, bacterial virus particles or packaged phagemids may target (e.g., specifically target) a bacterial cell from any one or more of the foregoing genus of bacteria to specifically deliver the payload according to the invention.

Preferably, the targeted bacteria can be selected from the group consisting of Yersinia spp., Escherichia spp., Klebsiella spp., Acinetobacter spp., Pseudomonas spp., Helicobacter spp., Vibrio spp, Salmonella spp., Streptococcus spp., Staphylococcus spp., Bacteroides spp., Clostridium spp., Shigella spp., Enterococcus spp., Enterobacter spp., Listeria spp., Cutibacterium spp., Propionibacterium spp., Fusobacterium spp., Porphyromonas spp. and Gardnerella spp.

In some embodiments, bacterial cells of the present invention are anaerobic bacterial cells (e.g., cells that do not require oxygen for growth). Anaerobic bacterial cells include facultative anaerobic cells such as but not limited to Escherichia coli, Shewanella oneidensi, Gardnerella vaginalis and Listeria. Anaerobic bacterial cells also include obligate anaerobic cells such as, for example, Bacteroides, Clostridium, Cutibacterium, Propionibacterium, Fusobacterium and Porphyromonas species. In humans, anaerobic bacteria are most commonly found in the gastrointestinal tract. In some particular embodiment, the targeted bacteria are thus bacteria most commonly found in the gastrointestinal tract. Bacteriophages used for preparing the bacterial virus particles, and then the bacterial virus particles, may target (e.g., to specifically target) anaerobic bacterial cells according to their specific spectra known by the person skilled in the art to specifically deliver the payload.

In some embodiments, the targeted bacterial cells are, without limitation, Bacteroides faecis, Bacteroides thetaiotaomicron, Bacteroides fragilis, Bacteroides distasonis, Bacteroides vulgatus, Clostridium leptum, Clostridium coccoides, Staphylococcus aureus, Bacillus subtilis, Clostridium butyricum, Brevibacterium lactofermentum, Streptococcus agalactiae, Lactococcus lactis, Leuconostoc lactis, Actinobacillus actinobycetemcomitans, cyanobacteria, Escherichia coli, Helicobacter pylori, Selnomonas ruminatium, Shigella sonnei, Zymomonas mobilis, Mycoplasma mycoides, Treponema denticola, Bacillus thuringiensis, Staphiococcus lugdunensis, Leuconostoc oenos, Corynebacterium xerosis, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus acidophilus, Enterococcus faecalis, Bacillus coagulans, Bacillus cereus, Bacillus popillae, Synechocystis strain PCC6803, Bacillus liquefaciens, Pyrococcus abyssi, Selenomonas nominantium, Lactobacillus hilgardii, Streptococcus ferus, Lactobacillus pentosus, Bacteroides fragilis, Staphylococcus epidermidis, Streptomyces phaechromogenes, Streptomyces ghanaenis, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Morganella morganii, Citrobacter freundii, Propionibacterium freudenreichii, Pseudomonas aerigunosa, Parvimonas micra, Prevotella intermedia, Fusobacterium nucleatum, Prevotella nigrescens, Actinomyces israelii, Porphyromonas endodontalis, Porphyromonas gingivalis Micrococcus luteus, Bacillus megaterium, Aeromonas hydrophila, Aeromonas caviae, Bacillus anthracis, Bartonella henselae, Bartonella Quintana, Bordetella pertussis, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelii, Borrelia recurrentis, Brucella abortus, Brucella canis, Brucella melitensis, Brucella suis, Campylobacter jejuni, Campylobacter coli, Campylobacter fetus, Chlamydia pneumoniae, Chlamydia trachomatis, Chlamydophila psittaci, Clostridium botulinum, Clostridium difficile, Clostridium perfringens, Clostridium tetani, Corynebacterium diphtheria, Cutibacterium acnes (formerly Propionibacterium acnes), Ehrlichia canis, Ehrlichia chaffeensis, Enterococcus faecium, Francisella tularensis, Haemophilus influenza, Legionella pneumophila, Leptospira interrogans, Leptospira santarosai, Leptospira weilii, Leptospira noguchii, Listeria monocytogenes, Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium ulcerans, Mycoplasma pneumonia, Neisseria gonorrhoeae, Neisseria meningitides, Nocardia asteroids, Rickettsia rickettsia, Salmonella enteritidis, Salmonella typhi, Salmonella paratyphi, Salmonella typhimurium, Shigella flexnerii, Shigella dysenteriae, Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Gardnerella vaginalis, Streptococcus viridans, Treponema pallidum, Ureaplasma urealyticum, Vibrio cholera, Vibrio parahaemolyticus, Yersinia pestis, Yersinia enterocolitica, Yersinia pseudotuberculosis, Actinobacter baumanii, Pseudomonas aerigunosa, and a mixture thereof, preferably the bacteria of interest are selected from the group consisting of Escherichia coli, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, Enterobacter cloacae, and Enterobacter aerogenes, and a mixture thereof.

In some embodiments, the targeted bacterial cells are, without limitation, Anaerotruncus, Acetanaerobacterium, Acetitomaculum, Acetivibrio, Anaerococcus, Anaerofilum, Anaerosinus, Anaerostipes, Anaerovorax, Butyrivibrio, Clostridium, Capracoccus, Dehalobacter, Dialister, Dorea, Enterococcus, Ethanoligenens, Faecalibacterium, Fusobacterium, Gracilibacter, Guggenheimella, Hespellia, Lachnobacterium, Lachnospira, Lactobacillus, Leuconostoc, Megamonas, Moryella, Mitsuokella, Oribacterium, Oxobacter, Papillibacter, Proprionispira, Pseudobutyrivibrio, Pseudoramibacter, Roseburia, Ruminococcus, Sarcina, Seinonella, Shuttleworthia, Sporobacter, Sporobacterium, Streptococcus, Subdoligranulum, Syntrophococcus, Thermobacillus, Turibacter, Weisella, Clostridium, Bacteroides, Ruminococcus, Faecalibacterium, Treponema, Phascolarctobacterium, Megasphaera, Faecalibacterium, Bifidobacterium, Lactobacillus, Sutterella, and/or Prevotella.

In other embodiments, the targeted bacteria cells are, without limitation, Achromobacter xylosoxidans, Acidaminococcus fermentans, Acidaminococcus intestini, Acidaminococcus sp., Acinetobacter baumannii, Acinetobacter junii, Acinetobacter Iwoffii, Actinobacillus capsulatus, Actinomyces naeslundii, Actinomyces neuii, Actinomyces odontolyticus, Actinomyces radingae, Adlercreutzia equolifaciens, Aeromicrobium massiliense, Aggregatibacter actinomycetemcomitans, Akkermansia muciniphila, Aliagarivorans marinus, Alistipes finegoldii, Alistipes indistinctus, Alistipes inops, Alistipes onderdonkii, Alistipes putredinis, Alistipes senegalensis, Alistipes shahii, Alistipes timonensis, Alloscardovia omnicolens, Anaerobacter polyendosporus, Anaerobaculum hydrogeniformans, Anaerococcus hydrogenalis, Anaerococcus prevotii, Anaerococcus senegalensis, Anaerofustis stercorihominis, Anaerostipes caccae, Anaerostipes hadrus, Anaerotruncus colihominis, Aneurinibacillus aneurinilyticus, Bacillus licheniformis, Bacillus massilioanorexius, Bacillus massiliosenegalensis, Bacillus simplex, Bacillus smithii, Bacillus subtilis, Bacillus thuringiensis, Bacillus timonensis, Bacteroides xylanisolvens, Bacteroides acidifaciens, Bacteroides caccae, Bacteroides capillosus, Bacteroides cellulosilyticus, Bacteroides clarus, Bacteroides coprocola, Bacteroides coprophilus, Bacteroides dorei, Bacteroides eggerthii, Bacteroides faecis, Bacteroides finegoldii, Bacteroides fluxus, Bacteroides fragilis, Bacteroides gallinarum, Bacteroides intestinalis, Bacteroides nordii, Bacteroides oleiciplenus, Bacteroides ovatus, Bacteroides pectinophilus, Bacteroides plebeius, Bacteroides salanitronis, Bacteroides salyersiae, Bacteroides sp., Bacteroides stercoris, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Bacteroides xylanisolvens, Bacteroidespectinophilus ATCC, Barnesiella intestinihominis, Bavariicoccus seileri, Bifidobacterium adolescentis, Bifidobacterium angulatum, Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium catenulatum, Bifidobacterium dentium, Bifidobacterium gallicum, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bifidobacterium stercoris, Bilophila wadsworthia, Blautia faecis, Blautia hansenii, Blautia hydrogenotrophica, Blautia luti, Blautia obeum, Blautia producta, Blautia wexlerae, Brachymonas chironomi, Brevibacterium senegalense, Bryantella formatexigens, butyrate-producing bacterium, Butyricicoccus pullicaecorum, Butyricimonas virosa, Butyrivibrio crossotus, Butyrivibrio fibrisolvens, Caldicoprobacter faecalis, Campylobacter concisus, Campylobacter jejuni, Campylobacter upsaliensis, Catenibacterium mitsuokai, Cedecea davisae, Cellulomonas massiliensis, Cetobacterium somerae, Citrobacter braakii, Citrobacter freundii, Citrobacter pasteurii, Citrobacter sp., Citrobacter youngae, Cloacibacillus evryensis, Clostridiales bacterium, Clostridioides difficile, Clostridium asparagiforme, Clostridium bartlettii, Clostridium boliviensis, Clostridium bolteae, Clostridium hathewayi, Clostridium hiranonis, Clostridium hylemonae, Clostridium leptum, Clostridium methylpentosum, Clostridium nexile, Clostridium orbiscindens, Clostridium ramosum, Clostridium scindens, Clostridium sp, Clostridium sp., Clostridium spiroforme, Clostridium sporogenes, Clostridium symbiosum, Collinsella aerofaciens, Collinsella intestinalis, Collinsella stercoris, Collinsella tanakaei, Coprobacillus cateniformis, Coprobacter fastidiosus, Coprococcus catus, Coprococcus comes, Coprococcus eutactus, Corynebacterium ammoniagenes, Corynebacterium amycolatum, Corynebacterium pseudodiphtheriticum, Cutibacterium acnes, Dermabacter hominis, Desulfitobacterium hafniense, Desulfovibrio fairfieldensis, Desulfovibrio piger, Dialister succinatiphilus, Dielma fastidiosa, Dorea formicigenerans, Dorea longicatena, Dysgonomonas capnocytophagoides, Dysgonomonas gadei, Dysgonomonas mossii, Edwardsiella tarda, Eggerthella lenta, Eisenbergiella tayi, Enorma massiliensis, Enterobacter aerogenes, Enterobacter asburiae, Enterobacter cancerogenus, Enterobacter cloacae, Enterobacter massiliensis, Enterococcus casseliflavus, Enterococcus durans, Enterococcus faecalis, Enterococcus faecium, Enterococcus flavescens, Enterococcus gallinarum, Enterococcus sp., Enterovibrio nigricans, Erysipelatoclostridium ramosum, Escherichia coli, Escherichia sp., Eubacterium biforme, Eubacterium dolichum, Eubacterium hallii, Eubacterium limosum, Eubacterium ramulus, Eubacterium rectale, Eubacterium siraeum, Eubacterium ventriosum, Exiguobacterium marinum, Exiguobacterium undae, Faecalibacterium cf, Faecalibacterium prausnitzii, Faecalitalea cylindroides, Ferrimonas balearica, Finegoldia magna, Flavobacterium daejeonense, Flavonifractor plautii, Fusicatenibacter saccharivorans, Fusobacterium gonidiaformans, Fusobacterium mortiferum, Fusobacterium necrophorum, Fusobacterium nucleatum, Fusobacterium periodonticum, Fusobacterium sp., Fusobacterium ulcerans, Fusobacterium varium, Gallibacterium anatis, Gemmiger formicilis, Gordonibacter pamelaeae, Hafnia alvei, Helicobacter bilis, Helicobacter bills, Helicobacter canadensis, Helicobacter canis, Helicobacter cinaedi, Helicobacter macacae, Helicobacter pametensis, Helicobacter pullorum, Helicobacter pylori, Helicobacter rodentium, Helicobacter winghamensis, Herbaspirillum massiliense, Holdemanella biformis, Holdemania fdiformis, Holdemania filiformis, Holdemania massiliensis, Holdemaniafiliformis, Hungatella hathewayi, Intestinibacter bartlettii, Intestinimonas butyriciproducens, Klebsiella oxytoca, Klebsiella pneumoniae, Kurthia massiliensis, Lachnospira pectinoschiza, Lactobacillus acidophilus, Lactobacillus amylolyticus, Lactobacillus animalis, Lactobacillus antri, Lactobacillus brevis, Lactobacillus buchneri, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus iners, Lactobacillus intestinalis, Lactobacillus johnsonii, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus ruminis, Lactobacillus sakei, Lactobacillus salivarius, Lactobacillus ultunensis, Lactobacillus vaginalis, Lactobacillus plantarum subsp., Leuconostoc mesenteroides, Leuconostoc pseudomesenteroides, Listeria grayi, Listeria innocua, Mannheimia granulomatis, Marvinbryantia formatexigens, Megamonas funiformis, Megamonas hypermegale, Methanobrevibacter smithii, Methanobrevibacter smithii FI, Micrococcus luteus, Microvirgula aerodenitrificans, Mitsuokella jalaludinii, Mitsuokella multacida, Mollicutes bacterium, Murimonas intestini, Neisseria macacae, Nitriliruptor alkaliphilus, Oceanobacillus massiliensis, Odoribacter laneus, Odoribacter splanchnicus, Ornithobacterium rhinotracheale, Oxalobacter formigenes, Paenibacillus barengoltzii, Paenibacillus chitinolyticus, Paenibacillus lautus, Paenibacillus motobuensis, Paenibacillus senegalensis, Paenisporosarcina quisquiliarum, Parabacteroides distasonis, Parabacteroides goldsteinii, Parabacteroides gordonii, Parabacteroides johnsonii, Parabacteroides merdae, Paraprevotella xylaniphila, Parasutterella excrementihominis, Parvimonas micra, Pediococcus acidilactici, Peptoclostridium difficile, Peptoniphilus harei, Peptoniphilus obesi, Peptoniphilus senegalensis, Peptoniphilus timonensis, Phascolarctobacterium succinatutens, Porphyromonas asaccharolytica, Porphyromonas uenonis, Prevotella baroniae, Prevotella bivia, Prevotella copri, Prevotella dentalis, Prevotella micans, Prevotella multisaccharivorax, Prevotella oralis, Prevotella salivae, Prevotella stercorea, Prevotella veroralis, Propionibacterium acnes, Propionibacterium avidum, Propionibacterium freudenreichii, Propionimicrobium lymphophilum, Proteus mirabilis, Proteuspenneri ATCC, Providencia alcalifaciens, Providencia rettgeri, Providencia rustigianii, Providencia stuartii, Pseudoflavonifractor capillosus, Pseudomonas aeruginosa, Pseudomonas luteola, Ralstonia pickettii, Rheinheimera perlucida, Rheinheimera texasensis, Riemerella columbina, Romboutsia lituseburensis, Roseburia faecis, Roseburia intestinalis, Roseburia inulinivorans, Ruminococcus bicirculans, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus champanellensis, Ruminococcus faecis, Ruminococcus gnavus, Ruminococcus lactaris, Ruminococcus obeum, Ruminococcus sp, Ruminococcus sp., Ruminococcus torques, Sarcina ventriculi, Sellimonas intestinalis, Senegalimassilia anaerobia, Shigella sonnei, Slackia piriformis, Staphylococcus epidermidis, Staphylococcus lentus, Staphylococcus nepalensis, Staphylococcus pseudintermedius, Staphylococcus xylosus, Stenotrophomonas maltophilia, Streptococcus agalactiae, Streptococcus anginosus, Streptococcus australis, Streptococcus caballi, Streptococcus castoreus, Streptococcus didelphis, Streptococcus equinus, Streptococcus gordonii, Streptococcus henryi, Streptococcus hyovaginalis, Streptococcus infantarius, Streptococcus infantis, Streptococcus lutetiensis, Streptococcus merionis, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus ovis, Streptococcus parasanguinis, Streptococcus plurextorum, Streptococcus porci, Streptococcus pyogenes, Streptococcus salivarius, Streptococcus sobrinus, Streptococcus thermophilus, Streptococcus thoraltensis, Streptomyces albus, Subdoligranulum variabile, Succinatimonas hippei, Sutterella parvirubra, Sutterella wadsworthensis, Terrisporobacter glycolicus, Terrisporobacter mayombei, Thalassobacillus devorans, Timonella senegalensis, Turicibacter sanguinis, unknown sp, unknown sp., Varibaculum cambriense, Veillonella atypica, Veillonella dispar, Veillonella parvula, Vibrio cincinnatiensis, Virgibacillus salexigens, and Weissella paramesenteroides. In other embodiments, the targeted bacteria cells are those commonly found on the skin microbiota and are without limitation Acetobacter farinalis, Acetobacter malorum, Acetobacter orleanensis, Acetobacter sicerae, Achromobacter anxifer, Achromobacter denitrificans, Achromobacter marplatensis, Achromobacter spanius, Achromobacter xylosoxidans subsp. xylosoxidans, Acidovorax konjaci, Acidovorax radicis, Acinetobacter johnsonii, Actinomadura citrea, Actinomadura coerulea, Actinomadura fibrosa, Actinomadura fulvescens, Actinomadura jiaoheensis, Actinomadura luteofluorescens, Actinomadura mexicana, Actinomadura nitritigenes, Actinomadura verrucosospora, Actinomadura yumaensis, Actinomyces odontolyticus, Actinomycetospora atypica, Actinomycetospora corticicola, Actinomycetospora rhizophila, Actinomycetospora rishiriensis, Aeromonas australiensis, Aeromonas bestiarum, Aeromonas bivalvium, Aeromonas encheleia, Aeromonas eucrenophila, Aeromonas hydrophila subsp. hydrophila, Aeromonas piscicola, Aeromonas popoffii, Aeromonas rivuli, Aeromonas salmonicida subsp. pectinolytica, Aeromonas salmonicida subsp. smithia, Amaricoccus kaplicensis, Amaricoccus veronensis, Aminobacter aganoensis, Aminobacter ciceronei, Aminobacter lissarensis, Aminobacter niigataensis, Ancylobacter polymorphus, Anoxybacillus flavithermus subsp. yunnanensis, Aquamicrobium aerolatum, Archangium gephyra, Archangium gephyra, Archangium minus, Archangium violaceum, Arthrobacter viscosus, Bacillus anthracis, Bacillus australimaris, Bacillus drentensis, Bacillus mycoides, Bacillus pseudomycoides, Bacillus pumilus, Bacillus safensis, Bacillus vallismortis, Bosea thiooxidans, Bradyrhizobium huanghuaihaiense, Bradyrhizobium japonicum, Brevundimonas aurantiaca, Brevundimonas intermedia, Burkholderia aspalathi, Burkholderia choica, Burkholderia cordobensis, Burkholderia diffusa, Burkholderia insulsa, Burkholderia rhynchosiae, Burkholderia terrestris, Burkholderia udeis, Buttiauxella gaviniae, Caenimonas terrae, Capnocytophaga gingivalis, Chitinophaga dinghuensis, Chryseobacterium gleum, Chryseobacterium greenlandense, Chryseobacterium jejuense, Chryseobacterium piscium, Chryseobacterium sediminis, Chryseobacterium tructae, Chryseobacterium ureilyticum, Chryseobacterium vietnamense, Corynebacterium accolens, Corynebacterium afermentans subsp. lipophilum, Corynebacterium minutissimum, Corynebacterium sundsvallense, Cupriavidus metallidurans, Cupriavidus nantongensis, Cupriavidus necator, Cupriavidus pampae, Cupriavidus yeoncheonensis, Curtobacterium flaccumfaciens, Devosia epidermidihirudinis, Devosia riboflavina, Devosia riboflavina, Diaphorobacter oryzae, Dietzia psychralcaliphila, Ensifer adhaerens, Ensifer americanus, Enterococcus malodoratus, Enterococcus pseudoavium, Enterococcus viikkiensis, Enterococcus xiangfangensis, Erwinia rhapontici, Falsirhodobacter halotolerans, Flavobacterium araucananum, Flavobacterium frigidimaris, Gluconobacter frateurii, Gluconobacter thailandicus, Gordonia alkanivorans, Halomonas aquamarina, Halomonas axialensis, Halomonas meridiana, Halomonas olivaria, Halomonas songnenensis, Halomonas variabilis, Herbaspirillum chlorophenolicum, Herbaspirillum frisingense, Herbaspirillum hiltneri, Herbaspirillum huttiense subsp. putei, Herbaspirillum lusitanum, Herminiimonas fonticola, Hydrogenophaga intermedia, Hydrogenophaga pseudoflava, Klebsiella oxytoca, Kosakonia sacchari, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus modestisalitolerans, Lactobacillus plantarum subsp. argentoratensis, Lactobacillus xiangfangensis, Lechevalieria roselyniae, Lentzea albida, Lentzea califomiensis, Leuconostoc carnosum, Leuconostoc citreum, Leuconostoc gelidum subsp. gasicomitatum, Leuconostoc mesenteroides subsp. suionicum, Luteimonas aestuarii, Lysobacter antibioticus, Lysobacter koreensis, Lysobacter oryzae, Magnetospirillum moscoviense, Marinomonas alcarazii, Marinomonas primoryensis, Massilia aurea, Massilia jejuensis, Massilia kyonggiensis, Massilia timonae, Mesorhizobium acaciae, Mesorhizobium qingshengii, Mesorhizobium shonense, Methylobacterium haplocladii, Methylobacterium platani, Methylobacterium pseudosasicola, Methylobacterium zatmanii, Microbacterium oxydan, Micromonospora chaiyaphumensis, Micromonospora chalcea, Micromonospora citrea, Micromonospora coxensis, Micromonospora echinofusca, Micromonospora halophytica, Micromonospora kangleipakensis, Micromonospora maritima, Micromonospora nigra, Micromonospora purpureochromogene, Micromonospora rhizosphaerae, Micromonospora saelicesensis, Micro virga subterranea, Microvirga zambiensis, Mycobacterium alvei, Mycobacterium avium subsp. silvaticum, Mycobacterium colombiense, Mycobacterium conceptionense, Mycobacterium conceptionense, Mycobacterium farcinogenes, Mycobacterium fortuitum subsp. fortuitum, Mycobacterium goodii, Mycobacterium insubricum, Mycobacterium Ilatzerense, Mycobacterium neoaurum, Mycobacterium neworleansense, Mycobacterium obuense, Mycobacterium peregrinum, Mycobacterium saopaulense, Mycobacterium septicum, Mycobacterium setense, Mycobacterium smegmatis, Neisseria subflava, Nocardia lijiangensis, Nocardia thailandica, Novosphingobium barchaimii, Novosphingobium lindaniclasticum, Novosphingobium lindaniclasticum, Novosphingobium mathurense, Ochrobactrum pseudogrignonense, Oxalicibacterium solurbis, Paraburkholderia glathei, Paraburkholderia humi, Paraburkholderia phenazinium, Paraburkholderia phytofirmans, Paraburkholderia sordidicola, Paraburkholderia terricola, Paraburkholderia xenovorans, Paracoccus laeviglucosivorans, Patulibacter ginsengiterrae, Polymorphospora rubra, Porphyrobacter colymbi, Prevotella jejuni, Prevotella melaninogenica, Propionibacterium acnes subsp. elongatum, Proteus vulgaris, Providencia rustigianii, Pseudoalteromonas agarivorans, Pseudoalteromonas atlantica, Pseudoalteromonas paragorgicola, Pseudomonas asplenii, Pseudomonas asuensis, Pseudomonas benzenivorans, Pseudomonas cannabina, Pseudomonas cissicola, Pseudomonas congelans, Pseudomonas costantinii, Pseudomonas ficuserectae, Pseudomonas frederiksbergensis, Pseudomonas graminis, Pseudomonas jessenii, Pseudomonas koreensis, Pseudomonas koreensis, Pseudomonas kunmingensis, Pseudomonas marginalis, Pseudomonas mucidolens, Pseudomonas panacis, Pseudomonas plecoglossicida, Pseudomonas poae, Pseudomonas pseudoalcaligenes, Pseudomonas putida, Pseudomonas reinekei, Pseudomonas rhizosphaerae, Pseudomonas seleniipraecipitans, Pseudomonas umsongensis, Pseudomonas zhaodongensis, Pseudonocardia alaniniphila, Pseudonocardia ammonioxydans, Pseudonocardia autotrophica, Pseudonocardia kongjuensis, Pseudonocardia yunnanensis, Pseudorhodoferax soli, Pseudoxanthomonas daejeonensis, Pseudoxanthomonas indica, Pseudoxanthomonas kaohsiungensis, Psychrobacter aquaticus, Psychrobacter arcticus, Psychrobacter celer, Psychrobacter marincola, Psychrobacter nivimaris, Psychrobacter okhotskensis, Psychrobacter okhotskensis, Psychrobacter piscatorii, Psychrobacter pulmonis, Ramlibacter ginsenosidimutans, Rheinheimera japonica, Rheinheimera muenzenbergensis, Rheinheimera soli, Rheinheimera tangshanensis, Rheinheimera texasensis, Rheinheimera tilapiae, Rhizobium alamii, Rhizobium azibense, Rhizobium binae, Rhizobium daejeonense, Rhizobium endophyticum, Rhizobium etli, Rhizobium fabae, Rhizobium freirei, Rhizobium gallicum, Rhizobium loessense, Rhizobium sophoriradicis, Rhizobium taibaishanense, Rhizobium vallis, Rhizobium vignae, Rhizobium vignae, Rhizobium yanglingense, Rhodococcus baikonurensis, Rhodococcus enclensis, Rhodoferax saidenbachensis, Rickettsia canadensis, Rickettsia heilongjiangensis, Rickettsia honei, Rickettsia raoultii, Roseateles aquatilis, Roseateles aquatilis, Salmonella enterica subsp. salamae, Serratia ficaria, Serratia myotis, Serratia vespertilionis, Shewanella aestuarii, Shewanella decolorationis, Sphingobium amiense, Sphingobium baderi, Sphingobium barthaii, Sphingobium chlorophenolicum, Sphingobium cupriresistens, Sphingobium czechense, Sphingobium fuliginis, Sphingobium indicum, Sphingobium indicum, Sphingobium japonicum, Sphingobium lactosutens, Sphingomonas dokdonensis, Sphingomonas pseudosanguinis, Sphingopyxis chilensis, Sphingopyxis fribergensis, Sphingopyxis granuli, Sphingopyxis indica, Sphingopyxis witflariensis, Staphylococcus agnetis, Staphylococcus aureus subsp. aureus, Staphylococcus epidermidis, Staphylococcus hominis subsp. novobiosepticus, Staphylococcus nepalensis, Staphylococcus saprophyticus subsp. bovis, Staphylococcus sciuri subsp. carnaticus, Streptomyces caeruleatus, Streptomyces canarius, Streptomyces capoamus, Streptomyces ciscaucasicus, Streptomyces griseorubiginosus, Streptomyces olivaceoviridis, Streptomyces panaciradicis, Streptomyces phaeopurpureus, Streptomyces pseudovenezuelae, Streptomyces resistomycificus, Tianweitania sediminis, Tsukamurella paurometabola, Variovorax guangxiensis, Vogesella alkaliphila, Xanthomonas arboricola, Xanthomonas axonopodis, Xanthomonas cassavae, Xanthomonas cucurbitae, Xanthomonas cynarae, Xanthomonas euvesicatoria, Xanthomonas fragariae, Xanthomonas gardneri, Xanthomonas perforans, Xanthomonas pisi, Xanthomonas populi, Xanthomonas vasicola, Xenophilus aerolatus, Yersinia nurmii, Abiotrophia defectiva, Acidocella aminolytica, Acinetobacter guangdongensis, Acinetobacter parvus, Acinetobacter radioresistens, Acinetobacter soli, Acinetobacter variabilis, Actinomyces cardiffensis, Actinomyces dentalis, Actinomyces europaeus, Actinomyces gerencseriae, Actinomyces graevenitzii, Actinomyces haliotis, Actinomyces johnsonii, Actinomyces massiliensis, Actinomyces meyeri, Actinomyces meyeri, Actinomyces naeslundii, Actinomyces neuii subsp. anitratus, Actinomyces odontolyticus, Actinomyces oris, Actinomyces turicensis, Actinomycetospora corticicola, Actinotignum schaalii, Aerococcus christensenii, Aerococcus urinae, Aeromicrobium flavum, Aeromicrobium massiliense, Aeromicrobium tamlense, Aeromonas sharmana, Aggregatibacter aphrophilus, Aggregatibactersegnis, Agrococcus baldri, Albibacter methylovorans, Alcaligenes faecalis subsp. faecalis, Algoriphagus ratkowskyi, Alkalibacterium olivapovliticus, Alkalibacterium pelagium, Alkalibacterium pelagium, Alloprevotella rava, Alsobacter metallidurans, Amaricoccus kaplicensis, Amaricoccus veronensis, Anaerococcus hydrogenalis, Anaerococcus lactolyticus, Anaerococcus murdochii, Anaerococcus octavius, Anaerococcus prevotii, Anaerococcus vaginalis, Aquabacterium citratiphilum, Aquabacterium olei, Aquabacterium olei, Aquabacterium parvum, Aquincola tertiaricarbonis, Arcobacter venerupis, Arsenicicoccus bolidensis, Arthrobacter russicus, Asticcacaulis excentricus, Atopobium deltae, Atopobium parvulum, Atopobium rimae, Atopobium vaginae, Aureimonas altamirensis, Aureimonas rubiginis, Azospira oryzae, Azospirillum oryzae, Bacillus circulans, Bacillus drentensis, Bacillus fastidiosus, Bacillus lehensis, Bacillus oceanisediminis, Bacillus rhizosphaerae, Bacteriovorax stolpii, Bacteroides coagulans, Bacteroides dorei, Bacteroides fragilis, Bacteroides ovatus, Bacteroides stercoris, Bacteroides uniformis, Bacteroides vulgatus, Bdellovibrio bacteriovorus, Bdellovibrio exovorus, Belnapia moabensis, Belnapia soli, Blautia hansenii, Blautia obeum, Blautia wexlerae, Bosea lathyri, Brachybacterium fresconis, Brachybacterium muris, Brevibacterium ammoniilyticum, Brevibacterium casei, Brevibacterium epidermidis, Brevibacterium iodinum, Brevibacterium luteolum, Brevibacterium paucivorans, Brevibacterium pityocampae, Brevibacterium sanguinis, Brevundimonas albigilva, Brevundimonas diminuta, Brevundimonas vancanneytii, Caenimonas terrae, Calidifontibacter indicus, Campylobacter concisus, Campylobacter gracilis, Campylobacter hominis, Campylobacter rectus, Campylobacter showae, Campylobacter ureolyticus, Capnocytophaga gingivalis, Capnocytophaga leadbetteri, Capnocytophaga ochracea, Capnocytophaga sputigena, Cardiobacterium hominis, Cardiobacterium valvarum, Carnobacterium divergens, Catonella morbi, Caulobacter henricii, Cavicella subterranea, Cellulomonas xylanilyfica, Cellvibrio vulgaris, Chitinimonas taiwanensis, Chryseobacterium arachidis, Chryseobacterium daecheongense, Chryseobacterium formosense, Chryseobacterium formosense, Chryseobacterium greenlandense, Chryseobacterium indologenes, Chryseobacterium piscium, Chryseobacterium rigui, Chryseobacterium solani, Chryseobacterium taklimakanense, Chryseobacterium ureilyticum, Chryseobacterium ureilyticum, Chryseobacterium zeae, Chryseomicrobium aureum, Cloacibacterium haliotis, Cloacibacterium normanense, Cloacibacterium normanense, Collinsella aerofaciens, Comamonas denitrificans, Comamonas terrigena, Corynebacterium accolens, Corynebacterium afermentans subsp. lipophilum, Corynebacterium ammoniagenes, Corynebacterium amycolatum, Corynebacterium aurimucosum, Corynebacterium aurimucosum, Corynebacterium coyleae, Corynebacterium durum, Corynebacterium freiburgense, Corynebacterium glaucum, Corynebacterium glyciniphilum, Corynebacterium imitans, Corynebacterium jeikeium, Corynebacterium jeikeium, Corynebacterium kroppenstedtii, Corynebacterium lipophiloflavum, Corynebacterium massiliense, Corynebacterium mastitidis, Corynebacterium matruchotii, Corynebacterium minutissimum, Corynebacterium mucifaciens, Corynebacterium mustelae, Corynebacterium mycetoides, Corynebacterium pyruviciproducens, Corynebacterium simulans, Corynebacterium singulare, Corynebacterium sputi, Corynebacterium suicordis, Corynebacterium tuberculostearicum, Corynebacterium tuberculostearicum, Corynebacterium ureicelerivorans, Corynebacterium variabile, Couchioplanes caeruleus subsp. caeruleus, Cupriavidus metallidurans, Curtobacterium herbarum, Dechloromonas agitata, Deinococcus actinosclerus, Deinococcus antarcticus, Deinococcus caeni, Deinococcus ficus, Deinococcus geothermalis, Deinococcus radiodurans, Deinococcus wulumuqiensis, Deinococcus xinjiangensis, Dermabacter hominis, Dermabacter vaginalis, Dermacoccus nishinomiyaensis, Desemzia incerta, Desertibacter roseus, Dialister invisus, Dialister micraerophilus, Dialister propionicifaciens, Dietzia aurantiaca, Dietzia cercidiphylli, Dietzia timorensis, Dietzia timorensis, Dokdonella koreensis, Dokdonella koreensis, Dolosigranulum pigrum, Eikenella corrodens, Elizabethkingia miricola, Elstera litoralis, Empedobacter brevis, Enhydrobacter aerosaccus, Enterobacter xiangfangensis, Enterococcus aquimarinus, Enterococcus faecalis, Enterococcus olivae, Erwinia rhapontici, Eubacterium eligens, Eubacterium infirmum, Eubacterium rectale, Eubacterium saphenum, Eubacterium sulci, Exiguobacterium mexicanum, Facklamia tabacinasalis, Falsirhodobacter halotolerans, Finegoldia magna, Flavobacterium cutihirudinis, Flavobacterium lindanitolerans, Flavobacterium resistens, Friedmanniella capsulata, Fusobacterium nucleatum subsp. polymorphum, Gemella haemolysans, Gemella morbillorum, Gemella palaticanis, Gemella sanguinis, Gemmobacter aquaticus, Gemmobacter caeni, Gordonia jinhuaensis, Gordonia kroppenstedtii, Gordonia polyisoprenivorans, Gordonia polyisoprenivorans, Granulicatella adiacens, Granulicatella elegans, Haemophilus parainfluenzae, Haemophilus sputorum, Halomonas suffidaeris, Herpetosiphon aurantiacus, Hydrocarboniphaga effusa, ldiomarina marls, Janibacter anophelis, Janibacter hoylei, Janibacter indicus, Janibacter limosus, Janibacter melonis, Jeotgalicoccus halophilus, Jonquetella anthropi, Kaistia geumhonensis, Kingella denitrificans, Kingella oralis, Klebsiella oxytoca, Knoellia aerolata, Knoellia locipacati, Kocuria atrinae, Kocuria camiphila, Kocuria kristinae, Kocuria palustris, Kocuria turfanensis, Lachnoanaerobaculum saburreum, Lachnoanaerobaculum saburreum, Lactobacillus crispatus, Lactobacillus iners, Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. lactis, Lactococcus piscium, Lapillicoccus jejuensis, Lautropia mirabilis, Legionella beliardensis, Leptotrichia buccalis, Leptotrichia goodfellowii, Leptotrichia hofstadii, Leptotrichia hongkongensis, Leptotrichia shahii, Leptotrichia trevisanii, Leptotrichia wadei, Luteimonas terricola, Lysinibacillus fusiformis, Lysobacter spongiicola, Lysobacter xinjiangensis, Macrococcus caseolyticus, Marmoricola pocheonensis, Marmoricola scoriae, Massilia alkalitolerans, Massilia alkalitolerans, Massilia aurea, Massilia plicata, Massilia timonae, Megamonas rupellensis, Meiothermus silvanus, Methylobacterium dankookense, Methylobacterium goesingense, Methylobacterium goesingense, Methylobacterium isbiliense, Methylobacterium jeotgali, Methylobacterium oxalidis, Methylobacterium platani, Methylobacterium pseudosasicola, Methyloversatilis universalis, Microbacterium foliorum, Microbacterium hydrothermale, Microbacterium hydrothermale, Microbacterium lacticum, Microbacterium lacticum, Microbacterium laevaniformans, Microbacterium paludicola, Microbacterium petrolearium, Microbacterium phyllosphaerae, Microbacterium resistens, Micrococcus antarcticus, Micrococcus cohnii, Micrococcus flavus, Micrococcus lylae, Micrococcus terreus, Microlunatus aurantiacus, Micropruina glycogenica, Microvirga aerilata, Microvirga aerilata, Microvirga subterranea, Microvirga vignae, Microvirga zambiensis, Microvirgula aerodenitrificans, Mogibacterium timidum, Moraxella atlantae, Moraxella catarrhalis, Morganella morganii subsp. morganii, Morganella psychrotolerans, Murdochiella asaccharolytica, Mycobacterium asiaticum, Mycobacterium chubuense, Mycobacterium crocinum, Mycobacterium gadium, Mycobacterium holsaticum, Mycobacterium iranicum, Mycobacterium longobardum, Mycobacterium neoaurum, Mycobacterium neoaurum, Mycobacterium obuense, Negativicoccus succinicivorans, Neisseria bacilliformis, Neisseria oralis, Neisseria sicca, Neisseria subflava, Nesterenkonia lacusekhoensis, Nesterenkonia rhizosphaerae, Nevskia persephonica, Nevskia ramosa, Niabella yanshanensis, Niveibacterium umoris, Nocardia niwae, Nocardia thailandica, Nocardioides agariphilus, Nocardioides dilutus, Nocardioides ganghwensis, Nocardioides hwasunensis, Nocardioides nanhaiensis, Nocardioides sediminis, Nosocomiicoccus ampullae, Noviherbaspirillum malthae, Novosphingobium lindaniclasticum, Novosphingobium rosa, Ochrobactrum rhizosphaerae, Olsenella uli, Ornithinimicrobium murale, Ornithinimicrobium tianjinense, Oryzobacterterrae, Ottowia beijingensis, Paenalcaligenes suwonensis, Paenibacillus agaridevorans, Paenibacillus phoenicis, Paenibacillus xylanexedens, Paludibacterium yongneupense, Pantoea cypripedii, Parabacteroides distasonis, Paraburkholderia andropogonis, Paracoccus alcaliphilus, Paracoccus angustae, Paracoccus kocurii, Paracoccus laeviglucosivorans, Paracoccus sediminis, Paracoccus sphaerophysae, Paracoccus yeei, Parvimonas micra, Parviterribacter multiflagellatus, Patulibacter ginsengiterrae, Pedobacter aquatilis, Pedobacter ginsengisoli, Pedobacter xixiisoli, Peptococcus niger, Peptoniphilus coxii, Peptoniphilus gorbachii, Peptoniphilus harei, Peptoniphilus koenoeneniae, Peptoniphilus lacrimalis, Peptostreptococcus anaerobius, Peptostreptococcus stomatis, Phascolarctobacterium faecium, Phenylobacterium haematophilum, Phenylobacterium kunshanense, Pluralibacter gergoviae, Polymorphobacter multimanifer, Porphyromonas bennonis, Porphyromonas endodontalis, Porphyromonas gingivalis, Porphyromonas gingivicanis, Porphyromonas pasteri, Porphyromonas pogonae, Porphyromonas somerae, Povalibacter uvarum, Prevotella aurantiaca, Prevotella baroniae, Prevotella bivia, Prevotella buccae, Prevotella buccalis, Prevotella copri, Prevotella corporis, Prevotella denticola, Prevotella enoeca, Prevotella histicola, Prevotella intermedia, Prevotella jejuni, Prevotella jejuni, Prevotella maculosa, Prevotella melaninogenica, Prevotella melaninogenica, Prevotella micans, Prevotella multiformis, Prevotella nanceiensis, Prevotella nigrescens, Prevotella oris, Prevotella oulorum, Prevotella pallens, Prevotella pleuritidis, Prevotella saccharolytica, Prevotella salivae, Prevotella shahii, Prevotella timonensis, Prevotella veroralis, Propionibacterium acidifaciens, Propionibacterium acnes subsp. acnes, Propionibacterium acnes subsp. acnes, Propionibacterium acnes subsp. elongatum, Propionibacterium granulosum, Propionimicrobium lymphophilum, Propionispira arcuata, Pseudokineococcus lusitanus, Pseudomonas aeruginosa, Pseudomonas chengduensis, Pseudonocardia benzenivorans, Pseudorhodoplanes sinuspersici, Psychrobacter sanguinis, Ramlibacter ginsenosidimutans, Rheinheimera aquimaris, Rhizobium alvei, Rhizobium daejeonense, Rhizobium larrymoorei, Rhizobium rhizoryzae, Rhizobium soli, Rhizobium taibaishanense, Rhizobium vignae, Rhodanobacter glycinis, Rhodobacter veldkampii, Rhodococcus enclensis, Rhodococcus fascians, Rhodococcus fascians, Rhodovarius lipocyclicus, Rivicola pingtungensis, Roseburia inulinivorans, Rosenbergiella nectarea, Roseomonas aerilata, Roseomonas aquatica, Roseomonas mucosa, Roseomonas rosea, Roseomonas vinacea, Rothia aeria, Rothia amarae, Rothia dentocariosa, Rothia endophytica, Rothia mucilaginosa, Rothia nasimurium, Rubellimicrobium mesophilum, Rubellimicrobium roseum, Rubrobacter bracarensis, Rudaea cellulosilytica, Ruminococcus gnavus, Runella zeae, Saccharopolyspora rectivirgula, Salinicoccus qingdaonensis, Scardovia wiggsiae, Sediminibacterium ginsengisoli, Selenomonas artemidis, Selenomonas infelix, Selenomonas noxia, Selenomonas sputigena, Shewanella aestuarii, Shuttleworthia satelles, Simonsiella muelleri, Skermanella aerolata, Skermanella stibiiresistens, Slackia exigua, Smaragdicoccus niigatensis, Sneathia sanguinegens, Solirubrobacter soli, Sphingobacterium caeni, Sphingobacterium daejeonense, Sphingobacterium hotanense, Sphingobacterium kyonggiense, Sphingobacterium multivorum, Sphingobacterium nematocida, Sphingobacterium spiritivorum, Sphingobium amiense, Sphingobium indicum, Sphingobium lactosutens, Sphingobium subterraneum, Sphingomonas abaci, Sphingomonas aestuarii, Sphingomonas canadensis, Sphingomonas daechungensis, Sphingomonas dokdonensis, Sphingomonas echinoides, Sphingomonas fonticola, Sphingomonas fonticola, Sphingomonas formosensis, Sphingomonas gei, Sphingomonas hankookensis, Sphingomonas hankookensis, Sphingomonas koreensis, Sphingomonas kyeonggiensis, Sphingomonas laterariae, Sphingomonas mucosissima, Sphingomonas oligophenolica, Sphingomonas pseudosanguinis, Sphingomonas sediminicola, Sphingomonas yantingensis, Sphingomonas yunnanensis, Sphingopyxis indica, Spirosoma rigui, Sporacetigenium mesophilum, Sporocytophaga myxococcoides, Staphylococcus auricularis, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus hominis subsp. novobiosepticus, Staphylococcus lugdunensis, Staphylococcus pettenkoferi, Stenotrophomonas koreensis, Stenotrophomonas rhizophila, Stenotrophomonas rhizophila, Streptococcus agalactiae, Streptococcus canis, Streptococcus cristatus, Streptococcus gordonii, Streptococcus infantis, Streptococcus intermedius, Streptococcus mutans, Streptococcus oligofermentans, Streptococcus oralis, Streptococcus sanguinis, Streptomyces iconiensis, Streptomyces yanglinensis, Tabrizicola aquatica, Tahibacter caeni, Tannerella forsythia, Tepidicella xavieri, Tepidimonas fonticaldi, Terracoccus luteus, Tessaracoccus flavescens, Thermus thermophilus, Tianweitania sediminis, Tianweitania sediminis, Treponema amylovorum, Treponema denticola, Treponema lecithinolyticum, Treponema medium, Turicella otitidis, Turicibacter sanguinis, Undibacterium oligocarboniphilum, Undibacterium squillarum, Vagococcus salmoninarum, Varibaculum cambriense, Vibrio metschnikovii, Xanthobacter tagetidis, Xenophilus aerolatus, Xenophilus arseniciresistens, Yimella lutea, Zimmermannella alba, Zimmermannella bifida and/or Zoogloea caeni.

In other embodiments, the targeted bacteria cells are those commonly found in the vaginal microbiota and are, without limitation, Acinetobacter antiviralis, Acinetobacter baumannii, Acinetobacter calcoaceticus, Acinetobacter johnsonii, Actinobaculum massiliense, Actinobaculum schaalii, Actinomyces europaeus, Actinomyces graevenitzii, Actinomyces israelii, Actinomyces meyeri, Actinomyces naeslundii, Actinomyces neuii, Actinomyces odontolyticus, Actinomyces turicensis, Actinomyces urogenitalis, Actinomyces viscosus, Aerococcus christensenii, Aerococcus urinae, Aerococcus viridans, Aeromonas encheleia, Aeromonas salmonicida, Afipia massiliensis, Agrobacterium tumefaciens, Algoriphagus aquatilis, Allivibrio wodanis, Alistipes finegoldii, Alloiococcus otitis, Alloprevotella tannerae, Alloscardovia omnicolens, Alteretythrobacter epoxidivorans, Ammoniphilus oxalaticus, Amnibacterium kyonggiense, Anaerococcus hydrogenalis, Anaerococcus lactolyticus, Anaerococcus murdochii, Anaerococcus obesiensis, Anaerococcus prevotii, Anaerococcus tetradius, Anaerococcus vaginalis, Anaeroglobus geminatus, Anoxybacillus pushchinoensis, Aquabacterium parvum, Arcanobacterium phocae, Arthrobacter aurescens, Asticcacaulis excentricus, Atopobium minutum, Atopobium parvulum, Atopobium rimae, Atopobium vaginae, Avibacterium gaffinarum, Bacillus acidicola, Bacillus atrophaeus, Bacillus cereus, Bacillus cibi, Bacillus coahuilensis, Bacillus gaemokensis, Bacillus methanolicus, Bacillus oleronius, Bacillus pumilus, Bacillus shackletonii, Bacillus sporothermodurans, Bacillus subtilis, Bacillus wakoensis, Bacillus weihenstephanensis, Bacteroides barnesiae, Bacteroides coagulans, Bacteroides dorei, Bacteroides faecis, Bacteroides forsythus, Bacteroides fragilis, Bacteroides nordii, Bacteroides ovatus, Bacteroides salyersiae, Bacteroides stercoris, Bacteroides uniformis, Bacteroides vulgatus, Bacteroides xylanisolvens, Bacteroides zoogleoformans, Bamesiella viscericola, Bhargavaea cecembensis, Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium dentium, Bifidobacterium logum subsp. infantis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bifidobacterium scardovii, Bilophila wadsworthia, Blautia hydrogenotrophica, Blautia obeum, Blautia producta, Brachybacterium faecium, Bradyrhizobium japonicum, Brevibacterium mcbrellneri, Brevibacterium otitidis, Brevibacterium paucivorans, Bulleidia extructa, Burkholderia fungorum, Burkholderia phenoliruptix, Caldicellulosiruptor saccharolyticus, Caldimonas taiwanensis, Campylobacter gracilis, Campylobacter hominis, Campylobacter sputorum, Campylobacter ureolyticus, Capnocytophaga ochracea, Cardiobacterium hominis, Catonella morbi, Chlamydia trachomatis, Chlamydophila abortus, Chondromyces robustus, Chryseobacterium aquaticum, Citrobacter youngae, Cloacibacterium normanense, Clostridium cavendishii, Clostridium colicanis, Clostridium jejuense, Clostridium perfringens, Clostridium ramosum, Clostridium sordellii, Clostridium viride, Comamonas terrigena, Corynebacterium accolens, Corynebacterium appendicis, Corynebacterium coyleae, Corynebacterium glucuronolyticum, Corynebacterium glutamicum, Corynebacterium jeikeium, Corynebacterium kroppenstedtii, Corynebacterium lipophiloflavum, Corynebacterium minutissimum, Corynebacterium mucifaciens, Corynebacterium nuruki, Corynebacterium pseudo genitalium, Corynebacterium pyruviciproducens, Corynebacterium singulare, Corynebacterium striatum, Corynebacterium tube rculostearicum, Corynebacterium xerosis, Cryobacterium psychrophilum, Curtobacterium flaccumfaciens, Cutibacterium acnes, Cutibacterium avidum, Cytophaga xylanolytica, Deinococcus radiophilus, Delftia tsuruhatensis, Desulfovibrio desulfuricans, Dialister invisus, Dialister micraerophilus, Dialister pneumosintes, Dialister propionicifaciens, Dickeya chrysanthemi, Dorea longicatena, Eggerthella lenta, Eggerthia catenaformis, Eikenella corrodens, Enhydrobacter aerosaccus, Enterobacter asburiae, Enterobacter cloacae, Enterococcus avium, Enterococcus durans, Enterococcus faecalis, Enterococcus faecium, Enterococcus hirae, Erwinia persicina, Erwinia rhapontici, Erwinia toletana, Escherichia coli, Escherichia fergusonii, Eubacterium brachy, Eubacterium eligens, Eubacterium nodatum, Eubacterium rectale, Eubacterium saphenum, Eubacterium siraeum, Eubacterium sulci, Eubacterium yurii, Exiguobacterium acetylicum, Facklamia ignava, Faecalibacterium prausnitzii, Filifactor alocis, Finegoldia magna, Fusobacterium gonidiaformans, Fusobacterium nucleatum, Fusobacterium periodonticum, Gardnerella vaginalis, Gemella asaccharolytica, Gemella bergeri, Gemella haemolysans, Gemella sanguinis, Geobacillus stearothermophilus, Geobacillus thermocatenulatus, Geobacillus thermoglucosidasius, Geobacter grbiciae, Granulicatella elegans, Haemophilus ducreyi, Haemophilus haemolyticus, Haemophilus parahaemolyticus, Haemophilus parainfluenzae, Hafnia alvei, Halomonas meridiana, Halomonas phoceae, Halomonas venusta, Herbaspirillum seropedicae, Janthinobacterium lividum, Jonquetella anthropi, Klebsiella granulomatis, Klebsiella oxytoca, Klebsiella pneumoniae, Lactobacillus acidophilus, Lactobacillus amylovorus, Lactobacillus brevis, Lactobacillus coleohominis, Lactobacillus crispatus, Lactobacillus curvatus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus iners, Lactobacillus jensenii, Lactobacillus johnsonii, Lactobacillus kalixensis, Lactobacillus kefiranofaciens, Lactobacillus kimchicus, Lactobacillus kitasatonis, Lactobacillus mucosae, Lactobacillus panis, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus pontis, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus ultunensis, Lactobacillus vaginalis, Lactococcus lactis, Leptotrichia buccalis, Leuconostoc carnosum, Leuconostoc citreum, Leuconostoc garlicum, Leuconostoc lactis, Leuconostoc mesenteroides, Lysinimonas kribbensis, Mageeibacillus indolicus, Maribacter orientalis, Marinomonas protea, Marinospirillum insulare, Massilia timonae, Megasphaera elsdenii, Megasphaera micronuciformis, Mesorhizobium amorphae, Methylobacterium radiotolerans, Methylotenera versatilis, Microbacterium halophilum, Micrococcus luteus, Microterricola viridarii, Mobiluncus curtisii, Mobiluncus mulieris, Mogibacterium timidum, Moorella glycerini, Moraxella osloensis, Morganella morganii, Moryella indoligenes, Murdochiella asaccharolytica, Mycoplasma alvi, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma muris, Mycoplasma salivarium, Negativicoccus succinicivorans, Neisseria flava, Neisseria gonorrhoeae, Neisseria mucosa, Neisseria subflava, Nevskia ramosa, Nevskia soli, Nitriliruptor alkaliphilus, Odoribacter splanchnicus, Oligella urethralis, Olsenella uli, Paenibacillus amylolyticus, Paenibacillus humicus, Paenibacillus pabuli, Paenibacillus pasadenensis, Paenibacillus pini, Paenibacillus validus, Pantoea agglomerans, Parabacteroides merdae, Paraburkholderia caryophylli, Paracoccus yeei, Parastreptomyces abscessus, Parvimonas micra, Pectobacterium betavasculorum, Pectobacterium carotovorum, Pediococcus acidilactici, Pediococcus ethanolidurans, Pedobacter alluvionis, Pedobacter wanjuense, Pelomonas aquatica, Peptococcus niger, Peptoniphilus asaccharolyticus, Peptoniphilus gorbachii, Peptoniphilus harei, Peptoniphilus indolicus, Peptoniphilus lacrimalis, Peptoniphilus massiliensis, Peptostreptococcus anaerobius, Peptostreptococcus massiliae, Peptostreptococcus stomatis, Photobacterium angustum, Photobacterium frigidiphilum, Photobacterium phosphoreum, Porphyromonas asaccharolytica, Porphyromonas bennonis, Porphyromonas catoniae, Porphyromonas endodontalis, Porphyromonas gingivalis, Porphyromonas somerae, Porphyromonas uenonis, Prevotella amnii, Prevotella baroniae, Prevotella bergensis, Prevotella bivia, Prevotella buccae, Prevotella buccalis, Prevotella colorans, Prevotella copri, Prevotella corporis, Prevotella dentalis, Prevotella denticola, Prevotella disiens, Prevotella intermedia, Prevotella loescheii, Prevotella marshii, Prevotella melaninogenica, Prevotella micans, Prevotella nigrescens, Prevotella oris, Prevotella pleuritidis, Prevotella ruminicola, Prevotella shahii, Prevotella stercorea, Prevotella timonensis, Prevotella veroralis, Propionimicrobium lymphophilum, Proteus mirabilis, Pseudomonas abietaniphila, Pseudomonas aeruginosa, Pseudomonas amygdali, Pseudomonas azotoformans, Pseudomonas chlororaphis, Pseudomonas cuatrocienegasensis, Pseudomonas fluorescens, Pseudomonas fulva, Pseudomonas lutea, Pseudomonas mucidolens, Pseudomonas oleovorans, Pseudomonas orientalis, Pseudomonas pseudoalcaligenes, Pseudomonas psychrophila, Pseudomonas putida, Pseudomonas synxantha, Pseudomonas syringae, Pseudomonas tolaasii, Pseudopropionibacterium propionicum, Rahnella aquatilis, Ralstonia pickettii, Ralstonia solanacearum, Raoultella planticola, Rhizobacter dauci, Rhizobium etli, Rhodococcus fascians, Rhodopseudomonas palustris, Roseburia intestinalis, Roseburia inulinivorans, Rothia mucilaginosa, Ruminococcus bromii, Ruminococcus gnavus, Ruminococcus torques, Sanguibacter keddieii, Sediminibacterium salmoneum, Selenomonas bovis, Serratia fonticola, Serratia liquefaciens, Serratia marcescens, Shewanella algae, Shewanella amazonensis, Shigella boydii, Shigella sonnei, Slackia exigua, Sneathia amnii, Sneathia sanguinegens, Solobacterium moorei, Sorangium cellulosum, Sphingobium amiense, Sphingobium japonicum, Sphingobium yanoikuyae, Sphingomonas wittichii, Sporosarcina aquimarina, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus capitis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus lugdunensis, Staphylococcus saprophyticus, Staphylococcus schleiferi, Staphylococcus simiae, Staphylococcus simulans, Staphylococcus wameri, Stenotrophomonas maltophilia, Stenoxybacter acetivorans, Streptococcus agalactiae, Streptococcus anginosus, Streptococcus australis, Streptococcus equinus, Streptococcus gallolyticus, Streptococcus infantis, Streptococcus intermedius, Streptococcus lutetiensis, Streptococcus marimammalium, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus parasanguinis, Streptococcus phocae, Streptococcus pseudo pneumoniae, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus thermophilus, Sutterella wadsworthensis, Tannerella forsythia, Terrahaemophilus aromaticivorans, Treponema denticola, Treponema maltophilum, Treponema parvum, Treponema vincentii, Trueperella bernardiae, Turicella otitidis, Ureaplasma parvum, Ureaplasma urealyticum, Varibaculum cambriense, Variovorax paradoxus, Veillonella atypica, Veillonella dispar, Veillonella montpellierensis, Veillonella parvula, Virgibacillus proomii, Viridibacillus arenosi, Viridibacillus arvi, Weissella cibaria, Weissella soli, Xanthomonas campestris, Xanthomonas vesicatoria, Zobellia laminariae and/or Zoogloea ramigera.

In one embodiment, the targeted bacteria are Escherichia coli.

In one embodiment, the targeted bacteria are Cutibacterium acnes more specifically the acne related Cutibacterium acnes from the phylogroup IA1 or RT4, RT5, RT8, RT9, RT10 or Clonal Complex (CC) CC1, CC3, CC4, more specifically the ST1, ST3, ST4.

Bacteriophages used for preparing bacterial virus particles such as packaged phagemids, may target (e.g., specifically target) a bacterial cell from any one or more of the disclosed genus and/or species of bacteria to specifically deliver the payload.

In one embodiment, the targeted bacteria are pathogenic bacteria. The targeted bacteria can be virulent bacteria.

The targeted bacteria can be antibacterial resistance bacteria, preferably selected from the group consisting of extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli, ESBL Klebsiella pneumoniae, vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) Acinetobacter baumannii, MDR Enterobacter spp., and a combination thereof. Preferably, the targeted bacteria can be selected from the group consisting of extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli strains.

Alternatively, the targeted bacterium can be a bacterium of the microbiome of a given species, preferably a bacterium of the human microbiota.

Bacterial Viruses

The bacterial virus particles are prepared from bacterial virus. The bacterial viruses are chosen in order to be able to introduce the payload into the targeted bacteria.

Bacterial viruses are preferably bacteriophages. Bacteriophages are obligate intracellular parasites that multiply inside bacteria by co-opting some or all of the host biosynthetic machinery. Phage genomes come in a variety of sizes and shapes (e.g., linear or circular). Most phages range in size from 24-200 nm in diameter. Phages contain nucleic acid (i.e., genome) and proteins, and may be enveloped by a lipid membrane. Depending upon the phage, the nucleic acid genome can be either DNA or RNA, and can exist in either circular or linear forms. The size of the phage genome varies depending upon the phage. The simplest phages have genomes that are only a few thousand nucleotides in size, while the more complex phages may contain more than 100,000 nucleotides in their genome, and in rare instances more than 1,000,000. The number and amount of individual types of protein in phage particles will vary depending upon the phage.

Optionally, the bacteriophage is selected from the Order Caudovirales consisting of, based on the taxonomy of Krupovic et al, Arch Virol, 2015:

- family Myoviridae (such as, without limitation, genus Cp220virus, Cp8virus, Ea214virus, Felixo1virus, Mooglevirus, Suspvirus, Hp1virus, P2virus, Kayvirus, P100virus, Silviavirus, Spo1virus, Tsarbombavirus, Twortvirus, Cc31virus, Jd18virus, Js98virus, Kp15virus, Moonvirus, Rb49virus, Rb69virus, S16virus, Schizot4virus, Sp18virus, T4virus, Cr3virus, Se1virus, V5virus, Abouovirus, Agatevirus, Agrican357virus, Ap22virus, Arv1virus, B4virus, Bastillevirus, Bc431virus, Bcep78virus, Bcepmuvirus, Biquartavirus, Bxz1virus, Cd119virus, Cp51virus, Cvm10virus, Eah2virus, E1virus, Hapunavirus, Jimmervirus, Kpp10virus, M12virus, Machinavirus, Marthavirus, Msw3virus, Muvirus, Myohalovirus, Nit1 virus, P1virus, Pakpunavirus, Pbunavirus, Phikzvirus, Rheph4virus, Rsl2virus, Rslunavirus, Secunda5virus, Sep1virus, Spn3virus, Svunavirus, Tg1virus, Vhmlvirus and Wphvirus)
- family Podoviridae (such as, without limitation, genus Fri1virus, Kp32virus, Kp34virus, Phikmvvirus, Pradovirus, Sp6virus, T7virus, Cp1virus, P68virus, Phi29virus, Nona33virus, Pocjvirus, TI2011virus, Bcep22virus, Bpp1virus, Cba41virus, Dfl12virus, Ea92virus, Epsilon15virus, F116virus, G7cvirus, Jwalphavirus, Kf1virus, Kpp25virus, Lit1virus, Luz24virus, Luz7virus, N4virus, Nonanavirus, P22virus, Pagevirus, Phieco32virus, Prtbvirus, Sp58virus, Una961virus and Vp5virus)
- family Siphoviridae (such as, without limitation, genus Camvirus, Likavirus, R4virus, Acadianvirus, Coopervirus, Pg1virus, Pipefishvirus, Rosebushvirus, Brujitavirus, Che9cvirus, Hawkeyevirus, Plotvirus, Jerseyvirus, Klgvirus, Sp31virus, Lmd1virus, Una4virus, Bongovirus, Reyvirus, Buttersvirus, Charlievirus, Redivirus, Baxtervirus, Nymphadoravirus, Bignuzvirus, Fishburnevirus, Phayoncevirus, Kp36virus, Rogue1virus, Rtpvirus, T1virus, Tlsvirus, Ab18virus, Amigovirus, Anatolevirus, Andromedavirus, Attisvirus, Barnyardvirus, Bernal13virus, Biseptimavirus, Bronvirus, C2virus, C5virus, Cba181virus, Cbastvirus, Cecivirus, Che8virus, Chivirus, Cjw1virus, Corndogvirus, Cronusvirus, D3112virus, D3virus, Decurrovirus, Demosthenesvirus, Doucettevirus, E125virus, Eiauvirus, Ff47virus, Gaiavirus, Gilesvirus, Gordonvirus, Gordtnkvirus, Harrisonvirus, Hk578virus, Hk97virus, Jenstvirus, Jwxvirus, Kelleziovirus, Korravirus, L5virus, Lambdavirus, Laroyevirus, Liefievirus, Marvinvirus, Mudcatvirus, N15virus, Nonagvirus, Np1virus, Omegavirus, P12002virus, P12024virus, P23virus, P70virus, Pa6virus, Pamx74virus, Patiencevirus, Pbi1virus, Pepy6virus, Pfr1virus, Phic31virus, Phicbkvirus, Phietavirus, Phife1virus, Phijl1virus, Pis4avirus, Psavirus, Psimunavirus, Rdj1virus, Rer2virus, Sap6virus, Send513virus, Septima3virus, Seuratvirus, Sextaecvirus, Sfi11virus, Sfi21dt1virus, Sitaravirus, Sk1virus, Slashvirus, Smoothievirus, Soupsvirus, Spbetavirus, Ssp2virus, T5virus, Tankvirus, Tin2virus, Titanvirus, Tm4virus, Tp21virus, Tp84virus, Triavirus, Trigintaduovirus, Vegasvirus, Vendettavirus, Wbetavirus, Wildcatvirus, Wizardvirus, Woesvirus, Xp10virus, Ydn12virus and Yuavirus)
- family Ackermannviridae (such as, without limitation, genus Ag3virus, Limestonevirus, Cba120virus and Vi1virus)

Optionally, the bacteriophage is not part of the Order Caudovirales but from families with Unassigned order such as, without limitation, family Tectiviridae (such as genus Alphatectivirus, Betatectivirus), family Corticoviridae (such as genus Corticovirus), family Inoviridae (such as genus Fibrovirus, Habenivirus, Inovirus, Lineavirus, Plectrovirus, Saetivirus, Vespertiliovirus), family Cystoviridae (such as genus Cystovirus), family Leviviridae (such as genus Allolevivirus, Levivirus), family Microviridae (such as genus Alpha3microvirus, G4microvirus, Phix174microvirus, Bdellomicrovirus, Chlamydiamicrovirus, Spiromicrovirus) and family Plasmaviridae (such as genus Plasmavirus).

Optionally, the bacteriophage is targeting Archea not part of the Order Caudovirales but from families with Unassigned order such as, without limitation, Ampullaviridae, FuselloViridae, Globuloviridae, Guttaviridae, Lipothrixviridae, Pleolipoviridae, Rudiviridae, Salterprovirus and Bicaudaviridae.

A non-exhaustive listing of bacterial genera and their known host-specific bacteria viruses is presented in the following paragraphs. Synonyms and spelling variants are indicated in parentheses. Homonyms are repeated as often as they occur (e.g., D, D, d). Unnamed phages are indicated by “NN” beside their genus and their numbers are given in parentheses.

Bacteria of the genus Actinomyces can be infected by the following phages: Av-I, Av-2, Av-3, BF307, CTI, CT2, CT3, CT4, CT6, CT7, CT8 and 1281.

Bacteria of the genus Aeromonas can be infected by the following phages: AA-I, Aeh2, N, PMI, TP446, 3, 4, 11, 13, 29, 31, 32, 37, 43, 43-10T, 51, 54, 55R.1, 56, 56RR2, 57, 58, 59.1, 60, 63, Aehl, F, PM2, 1, 25, 31, 40RR2.8t, (syn=44R), (syn=44RR2.8t), 65, PM3, PM4, PM5 and PM6.

Bacteria of the genus Bacillus can be infected by the following phages: A, aizI, AI-K-I, B, BCJAI, BCI, BC2, BLLI, BLI, BP142, BSLI, BSL2, BSI, BS3, BS8, BS15, BS18, BS22, BS26, BS28, BS31, BS104, BS105, BS106, BTB, B1715V1, C, CK-I, ColI, CorI, CP-53, CS-I, CSi, D, D, D, D5, entl, FP8, FP9, FSi, FS2, FS3, FS5, FS8, FS9, G, GH8, GT8, GV-I, GV-2, GT-4, g3, gl2, gl3, gl4, gl6, gl7, g21, g23, g24, g29, H2, kenl, KK-88, Kuml, Kyul, J7W-1, LP52, (syn=LP-52), L7, Mexl, MJ-I, mor2, MP-7, MPIO, MP12, MP14, MP15, Neol, N^o2, N5, N6P, PBCI, PBLA, PBPI, P2, S-a, SF2, SF6, ShaI, SilI, SP02, (syn=φSPP1), SPβ, STI, STi, SU-11, t, TbI, Tb2, Tb5, TbIO, Tb26, Tb51, Tb53, Tb55, Tb77, Tb97, Tb99, Tb560, Tb595, Td8, Td6, Tdl5, TgI, Tg4, Tg6, Tg7, Tg9, TglI, TglI, Tgl3, Tgl5, Tg21, TinI, Tin7, Tin8, Tinl3, Tm3, TocI, TogI, tolI, TP-1, TP-10vir, TP-15c, TP-16c, TP-17c, TP-19, TP35, TP51, TP-84, Tt4, Tt6, type A, type B, type C, type D, type E, Tφ3, VA-9, W, wx23, wx26, YunI, α, γ, p I, φmed-2, φT, φμ-4, φ3T, φ75, φIO5, (syn=φIO5), IA, IB, 1-97A, 1-97B, 2, 2, 3, 3, 3, 5, 12, 14, 20, 30, 35, 36, 37, 38, 41C, 51, 63, 64, 138D, I, II, IV, NN-Bacillus (13), aleI, ARI, AR2, AR3, AR7, AR9, Bace-11, (syn=11), Bastille, BLI, BL2, BL3, BL4, BL5, BL6, BL8, BL9, BP124, BS28, BS80, Ch, CP-51, CP-54, D-5, dart, dent, DP-7, entl, FoSi, FoS2, FS4, FS6, FS7, G, gall, gamma, GEI, GF-2, GSi, GT-I, GT-2, GT-3, GT-4, GT-5, GT-6, GT-7, GV-6, gl5, 19, 110, ISi, K, MP9, MP13, MP21, MP23, MP24, MP28, MP29, MP30, MP32, MP34, MP36, MP37, MP39, MP40, MP41, MP43, MP44, MP45, MP47, MP50, NLP-I, No. I, N17, N19, PBSI, PKI, PMBI, PMB12, PMJI, S, SPOI, SP3, SP5, SP6, SP7, SP8, SP9, SPIO, SP-15, SP50, (syn=SP-50), SP82, SST, subI, SW, Tg8, Tgl2, Tgl3, Tgl4, thuI, thuΛ, thuS, Tin4, Tin23, TP-13, TP33, TP50, TSP-I, type V, type VI, V, Vx, β22, φe, φNR2, φ25, φ63, 1, 1, 2, 2C, 3NT, 4, 5, 6, 7, 8, 9, 10, 12, 12, 17, 18, 19, 21, 138, III, 4 (B. megateriwn), 4 (B. sphaericus), AR13, BPP-IO, BS32, BS107, BI, B2, GA-1, GP-10, GV-3, GV-5, g8, MP20, MP27, MP49, Nf, PPS, PP6, SF5, Tgl8, TP-I, Versailles, φI5, φ29, 1-97, 837/IV, mï-Bacillus (1), BatIO, BSLIO, BSLI 1, BS6, BSI I, BS16, BS23, BSIOI, BS102, gl8, morI, PBLI, SN45, thu2, thu3, TmI, Tm2, TP-20, TP21, TP52, type F, type G, type IV, HN-BacMus (3), BLE, (syn=θc), BS2, BS4, BS5, BS7, BIO, B12, BS20, BS21, F, MJ-4, PBA12, AP50, AP50-04, AP50-11, AP50-23, AP50-26, AP50-27 and Bam35. The following Bacillus-specific phages are defective: DLP10716, DLP-11946, DPBS, DPB12, DPB21, DPB22, DPB23, GA-2, M, No. IM, PBLB, PBSH, PBSV, PBSW, PBSX, PBSY, PBSZ, phi, SPa, type 1 and μ.

Bacteria of the genus Bacteroides can be infected by the following phages: crAss-phage, ad I2, Baf-44, Baf-48B, Baf-64, Bf-I, Bf-52, B40-8, FI, βI, φAI, φBrOI, φBrO2, 11, 67.1, 67.3, 68.1, mt-Bacteroides (3), Bf42, Bf71, HN-Bdellovibrio (1) and BF-41.

Bacteria of the genus Bordetella can be infected by the following phages: 134 and NN-Bordetella (3).

Bacteria of the genus Borrellia can be infected by the following phages: NN-Borrelia (1) and NN-Borrelia (2).

Bacteria of the genus Brucella can be infected by the following phages: A422, Bk, (syn=Berkeley), BM29, FOi, (syn=FOI), (syn=FQI), D, FP2, (syn=FP2), (syn=FD2), Fz, (syn=Fz75/13), (syn=Firenze 75/13), (syn=Fi), Fi, (syn=FI), Fim, (syn=FIm), (syn=Fim), FiU, (syn=FIU), (syn=FiU), F2, (syn=F2), F3, (syn=F3), F4, (syn=F4), F5, (syn=F5), F6, F7, (syn=F7), F25, (syn=F25), (syn=£25), F25U, (syn=F25u), (syn=F25U), (syn=F25V), F44, (syn-F44), F45, (syn=F45), F48, (syn=F48), I, Im, M, MC/75, M51, (syn=M85), P, (syn=D), S708, R, Tb, (syn=TB), (syn=Tbilisi), W, (syn=Wb), (syn=Weybridge), X, 3, 6, 7, 10/1, (syn=10), (syn=F8), (syn=F8), 12m, 24/11, (syn=24), (syn=F9), (syn=F9), 45/111, (syn=45), 75, 84, 212/XV, (syn=212), (syn=Fi0), (syn=FIO), 371/XXIX, (syn=371), (syn=Fn), (syn=FI I) and 513.

Bacteria of the genus Burkholderia can be infected by the following phages: CP75, NN-Burkholderia (1) and 42.

Bacteria of the genus Campylobacter can be infected by the following phages: C type, NTCC12669, NTCC12670, NTCC12671, NTCC12672, NTCC12673, NTCC12674, NTCC12675, NTCC12676, NTCC12677, NTCC12678, NTCC12679, NTCC12680, NTCC12681, NTCC12682, NTCC12683, NTCC12684, 32f, 111c, 191, NN-Campylobacter (2), Vfi-6, (syn=V19), VfV-3, V2, V3, V8, V16, (syn=Vfi-1), V19, V20(V45), V45, (syn=V-45) and NN-Campylobacter (1).

Bacteria of the genus Chlamydia can be infected by the following phage: ChpI.

Bacteria of the genus Clostridium can be infected by the following phages: CAKI, CA5, Ca7, CEβ, (syn=10), CEγ, CldI, c-n71, c-203 Tox-, DEβ, (syn=ID), (syn=IDt0X+), HM3, KMI, KT, Ms, NAI, (syn=Naltox+), PA135Oe, Pfó, PL73, PL78, PL81, PI, P50, P5771, P19402, ICt0X+, 2Ct0X\ 2D3 (syn=2Dt0X+), 3C, (syn=3Ctox+), 4C, (syn=4Ct0X+), 56, III-I, NN-Clostridium (61), NBIt0X+, αI, CAI, HMT, HM2, PFI5 P-23, P-46, Q-05, Q-oe, Q-16, Q-21, Q-26, Q-40, Q-46, S111, SA02, WA01, WA03, Wm, W523, 80, C, CA2, CA3, CPTI, CPT4, cI, c4, c5, HM7, H11/A1, H18/Ax, FWS23, Hi58ZA1, K2ZA1, K21ZS23, ML, NA2t0X; Pf2, Pf3, Pf4, S9ZS3, S41ZA1, S44ZS23, α2, 41, 112ZS23, 214/S23, 233/Ai, 234/S23, 235/S23, II-I, II-2, II-3, NN-Clostridium (12), CAI, FI, K, S2, 1, 5 and NN-Clostridium (8).

Bacteria of the genus Corynebacterium can be infected by the following phages: CGKI (defective), A, A2, A3, A101, A128, A133, A137, A139, A155, A182, B, BF, B17, B18, B51, B271, B275, B276, B277, B279, B282, C, capi, CCI, CGI, CG2, CG33, CL31, Cog, (syn=CG5), D, E, F, H, H-I, hqi, hq2, 11ZH33, li/31, J, K, K, (syn=Ktox″), L, L, (syn=Ltox+), M, MC-I, MC-2, MC-3, MC-4, MLMa, N, O, ovi, ov2, ov3, P, P, R, RP6, RS29, S, T, U, UB1, ub2, UH1, UH3, uh3, uh5, uh6, β, (syn=βtox+), βhv64, βvir, γ, (syn=γtoχ−), γI9, δ, (syn=δ′ox+), p, (syn=ptoχ−), ϕ9, φ984, ω, IA, 1/1180, 2, 2/1180, 5/1180, 5ad/9717, 7/4465, 8/4465, 8ad/10269, 10/9253, 13Z9253, 15/3148, 21/9253, 28, 29, 55, 2747, 2893, 4498 and 5848.

Bacteria of the genus Enterococcus are infected by the following phage: DF78, FI, F2, 1, 2, 4, 14, 41, 867, DI, SB24, 2BV, 182, 225, C2, C2F, E3, E62, DS96, H24, M35, P3, P9, SBIOI, S2, 2BII, 5, 182a, 705, 873, 881, 940, 1051, 1057, 21096C, NN-Enterococcus (1), PEI, FI, F3, F4, VD13, 1, 200, 235 and 341.

Bacteria of the genus Erysipelothrix can be infected by the following phage: NN-Eiysipelothrix (1).

Bacteria of the genus Escherichia can be infected by the following phages: BW73, B278, D6, D108, E, El, E24, E41, FI-2, FI-4, FI-5, HI8A, FfI8B, i, MM, Mu, (syn=mu), (syn=MuI), (syn=Mu-I), (syn=MU-I), (syn=MuI), (syn=μ), 025, PhI-5, Pk, PSP3, PI, PID, P2, P4 (defective), SI, Wφ, φK13, φR73 (defective), φI, φ2, φ7, φ92, ψ (defective), 7 A, 8φ, 9φ, 15 (defective), 18, 28-1, 186, 299, HH-Escherichia (2), AB48, CM, C4, C16, DD-VI, (syn=Dd-Vi), (syn=DDVI), (syn=DDVi), E4, E7, E28, FII, FI3, H, HI, H3, H8, K3, M, N, ND-2, ND-3, ND4, ND-5, ND6, ND-7, Ox-I (syn=OXI), (syn=HF), Ox-2 (syn=0x2), (syn=0X2), Ox-3, Ox-4, Ox-5, (syn=0X5), Ox-6, (syn=66F), (syn=φ66t), (syn=φ66t-)5 0111, PhI-I, RB42, RB43, RB49, RB69, S, Sal-I, Sal-2, Sal-3, Sal-4, Sal-5, Sal-6, TC23, TC45, TulI*-6, (syn=TulI*), TulP-24, TulI*46, TulP-60, T2, (syn=ganuTia), (syn=γ), (syn=PC), (syn=P.C.), (syn=T-2), (syn=T2), (syn=P4), T4, (syn=T-4), (syn=T4), T6, T35, αI, 1, IA, 3, (syn=Ac3), 3A, 3T+, (syn=3), (syn=MI), 5φ, (syn=φ5), 9266Q, CFO103, HK620, J, K, KIF, m59, no. A, no. E, no. 3, no. 9, N4, sd, (syn=Sd), (syn=SD), (syn=Sa)3 (syn=sd), (syn=SD), (syn=CD), T3, (syn=T-3), (syn=T3), T7, (syn=T-7), (syn=T7), WPK, W31, ΔH, φC3888, φK3, φK7, φK12, φV-1, φ04-CF, φ05, φ06, φ07, φI, φI.2, φ20, φ95, φ263, φIO92, φI, φII, (syn=φW), Ω8, 1, 3, 7, 8, 26, 27, 28-2, 29, 30, 31, 32, 38, 39, 42, 933W, NN-Escherichia (1), Esc-7-11, AC30, CVX-5, CI, DDUP, ECI, EC2, E21, E29, FI, F26S, F27S, Hi, HK022, HK97, (syn=ϕHK97), HK139, HK253, HK256, K7, ND-1, no.D, PA-2, q, S2, TI, (syn=α), (syn=P28), (syn=T-I), (syn=Tx), T3C, T5, (syn=T-5), (syn=T5), UC-I, w, β4, γ2, λ (syn=lambda), (syn=ϕλ), ϕD326, ϕγ, ϕ06, ϕ7, ϕ10, φ80, χ, (syn=χi), (syn=φχ), (syn=φχi), 2, 4, 4A, 6, 8A, 102, 150, 168, 174, 3000, AC6, AC7, AC28, AC43, AC50, AC57, AC81, AC95, HK243, KIO, ZG/3A, 5, 5A, 21EL, H19-J, 933H, O157 typing phages 1 to 16, JES-2013, 121Q, 172-1, 1720a-02, ADB-2, AKFV33, av-05, bVEcoS_AHP42, bV_EcoS_AHP24, bC_EcoS_AHS24, bV_EcoS_AKS96, CBA120.

Bacteria of the genus Fusobacterium are infected by the following phage: NN-Fusobacterium (2), fv83-554/3, fv88-531/2, 227, fv2377, fv2527 and fv8501.

Bacteria of the genus Haemophilus are infected by the following phage: HPI, S2 and N3.

Bacteria of the genus Helicobacter are infected by the following phage: HPI and {circumflex over ( )}{circumflex over ( )} Helicobacter (1).

Bacteria of the genus Klebsiella are infected by the following phage: AIO-2, KI4B, KI6B, K19, (syn=K19), KI14, KI15, KI21, KI28, KI29, KI32, KI33, KI35, KI106B, KI171B, KI181B, KI832B, AIO-1, AO-I, AO-2, AO-3, FC3-10, K, KI1, (syn=KII), KI2, (syn=KI2), KI3, (syn=K13), (syn=KI 70/11), KI4, (syn=K14), KI5, (syn=K15), KI6, (syn=K16), KI7, (syn=K17), KI8, (syn=K18), KI19, (syn=K19), KI27, (syn=K127), KI31, (syn=K131), KI35, KI171B, II, VI, IX, CI-I, KI4B, KI8, KI11, KI12, KI13, KI16, KI17, KI18, KI20, KI22, KI23, KI24, KI26, KI30, KI34, KI106B, KIi65B, KI328B, KLXI, K328, P5046, 11, 380, III, IV, VII, VIII, FC3-11, KI2B, (syn=K12B), KI25, (syn=K125), KI42B, (syn=K142), (syn=K142B), KI181B, (syn=KII 81), (syn=K1181B), KI765/!, (syn=KI765/1), KI842B, (syn=KI832B), KI937B, (syn=KI937B), LI, φ28, 7, 231, 483, 490, 632 and 864/100.

Bacteria of the genus Leptospira are infected by the following phage: LEI, LE3, LE4 and ˜NN-Leptospira (1).

Bacteria of the genus Listeria are infected by the following phage: A511, 01761, 4211, 4286, (syn=BO54), A005, A006, A020, A500, A502, A511, AI 18, A620, A640, B012, B021, B024, B025, B035, B051, B053, B054, B055, B056, BIOI, BI IO, B545, B604, B653, C707, D441, HSO47, HIOG, H8/73, H19, H21, H43, H46, H107, H108, HI IO, H163/84, H312, H340, H387, H391/73, H684/74, H924A, PSA, U153, φMLUP5, (syn=P35), 00241, 00611, 02971A, 02971C, 5/476, 5/911, 5/939, 5/11302, 5/11605, 5/11704, 184, 575, 633, 699/694, 744, 900, 1090, 1317, 1444, 1652, 1806, 1807, 1921/959, 1921/11367, 1921/11500, 1921/11566, 1921/12460, 1921/12582, 1967, 2389, 2425, 2671, 2685, 3274, 3550, 3551, 3552, 4276, 4277, 4292, 4477, 5337, 5348/11363, 5348/11646, 5348/12430, 5348/12434, 10072, 11355C, 11711A, 12029, 12981, 13441, 90666, 90816, 93253, 907515, 910716 and NN-Listeria (15).

Bacteria of the genus Morganella are infected by the following phage: 47.

Bacteria of the genus Mycobacterium are infected by the following phage: 13, AGI, ALi, ATCC 11759, A2, B.C3, BG2, BKI, BK5, butyricum, B-I, B5, B7, B30, B35, Clark, CI, C2, DNAIII, DSP1, D4, D29, GS4E, (syn=GS4E), GS7, (syn=GS-7), (syn=GS7), IPa, lacticola, Legendre, Leo, L5, (syn=ϕL-5), MC-I, MC-3, MC-4, minetti, MTPHI I, Mx4, MyF3P/59a, phlei, (syn=phlei 1), phlei 4, Polonus II, rabinovitschi, smegmatis, TM4, TM9, TMIO, TM20, Y7, YIO, φ630, IB, IF, IH, 1/1, 67, 106, 1430, BI, (syn=Bol), B24, D, D29, F-K, F-S, HP, Polonus I, Roy, RI, (syn=RI-Myb), (syn=Ri), 11, 31, 40, 50, 103a, 103b, 128, 3111-D, 3215-D and NN-Mycobacterium (1).

Bacteria of the genus Neisseria are infected by the following phage: Group I, group II and NPI.

Bacteria of the genus Nocardia are infected by the following phage: MNP8, NJ-L, NS-8, N5 and TtiN-Nocardia.

Bacteria of the genus Proteus are infected by the following phage: Pm5, 13vir, 2/44, 4/545, 6/1004, 13/807, 20/826, 57, 67b, 78, 107/69, 121, 9/0, 22/608, 30/680, PmI, Pm3, Pm4, Pm6, Pm7, Pm9, PmIO, PmI I, Pv2, πI, φm, 7/549, 9B/2, 10A/31, 12/55, 14, 15, 16/789, 17/971, 19A/653, 23/532, 25/909, 26/219, 27/953, 32A/909, 33/971, 34/13, 65, 5006M, 7480b, VI, 13/3a, Clichy 12, π2600, φχ7, 1/1004, 5/742, 9, 12, 14, 22, 24/860, 2600/D52, Pm8 and 24/2514.

Bacteria of the genus Providencia are infected by the following phage: PL25, PL26, PL37, 9211/9295, 9213/921 Ib, 9248, 7/R49, 7476/322, 7478/325, 7479, 7480, 9000/9402 and 9213/921 Ia.

Bacteria of the genus Pseudomonas are infected by the following phage: PfI, (syn=Pf-I), Pf2, Pf3, PP7, PRRI, 7s, im-Pseudomonas (1), AI-I, AI-2, B 17, B89, CB3, Col 2, Col 11, Col 18, Col 21, C154, C163, C167, C2121, E79, F8, ga, gb, H22, K1, M4, N2, Nu, PB-I, (syn=PBI), pfI6, PMN17, PPI, PP8, PsaI, PsPI, PsP2, PsP3, PsP4, PsP5, PS3, PS17, PTB80, PX4, PX7, PYOI, PYO2, PYO5, PYO6, PYO9, PYOIO, PYO13, PYO14, PYO16, PYO18, PYO19, PYO20, PYO29, PYO32, PYO33, PYO35, PYO36, PYO37, PYO38, PYO39, PYO41, PYO42, PYO45, PYO47, PYO48, PYO64, PYO69, PYO103, PIK, SLPI, SL2, S2, UNL-I, wy, Yai, Ya4, Yan, φBE, φCTX, φC17, φKZ, (syn=ϕKZ), φ-LT, ϕmu78, φNZ, φPLS-1, φST-1, φW-14, φ-2, 1/72, 2/79, 3, 3/DO, 4/237, 5/406, 6C, 6/6660, 7, 7v, 7/184, 8/280, 9/95, 10/502, 11/DE, 12/100, 12S, 16, 21, 24, 25F, 27, 31, 44, 68, 71, 95, 109, 188, 337, 352, 1214, HN-Pseudomonas (23), A856, B26, CI-I, CI-2, C5, D, gh-1, FI 16, HF, H90, K5, K6, KI 04, K109, K166, K267, N4, N5, O6N-25P, PE69, Pf, PPN25, PPN35, PPN89, PPN91, PP2, PP3, PP4, PP6, PP7, PP8, PP56, PP87, PPI 14, PP206, PP207, PP306, PP651, Psp231a, Pssy401, Pssy9220, psi, PTB2, PTB20, PTB42, PXI, PX3, PXIO, PX12, PX14, PYO70, PYO71, R, SH6, SH133, tf, Ya5, Ya7, φBS, ϕKf77, φ-MC, ϕmnF82, φPLS27, φPLS743, φS-1, 1, 2, 2, 3, 4, 5, 6, 7, 7, 8, 9, 10, 11, 12, 12B, 13, 14, 15, 14, 15, 16, 17, 18, 19, 20, 20, 21, 21, 22, 23, 23, 24, 25, 31, 53, 73, 119x, 145, 147, 170, 267, 284, 308, 525, NN-Pseudomonas (5), af, A7, B3, B33, B39, BI-I, C22, D3, D37, D40, D62, D3112, F7, FIO, g, gd, ge, gξ HwI2, Jb 19, KFI, L^o, OXN-32P, O6N-52P, PCH-I, PC13-1, PC35-1, PH2, PH51, PH93, PH132, PMW, PM13, PM57, PM61, PM62, PM63, PM69, PM105, PMI 13, PM681, PM682, PO4, PPI, PP4, PP5, PP64, PP65, PP66, PP71, PP86, PP88, PP92, PP401, PP711, PP891, Pssy41, Pssy42, Pssy403, Pssy404, Pssy420, Pssy923, PS4, PS-IO, Pz, SDI, SLI, SL3, SL5, SM, φC5, φCI I, φCI I-1, φC13, φC15, φMO, φX, φO4, φI I, φ240, 2, 2F, 5, 7m, 11, 13, 13/441, 14, 20, 24, 40, 45, 49, 61, 73, 148, 160, 198, 218, 222, 236, 242, 246, 249, 258, 269, 295, 297, 309, 318, 342, 350, 351, 357-1, 400-1, HN-Pseudomonas (6), G101, M6, M6a, LI, PB2, PssyI5, Pssy4210, Pssy4220, PYO12, PYO34, PYO49, PYO50, PYO51, PYO52, PYO53, PYO57, PYO59, PYO200, PX2, PX5, SL4, φO3, φO6 and 1214.

Bacteria of the genus Rickettsia are infected by the following phage: NN-Rickettsia.

Bacteria of the genus Salmonella are infected by the following phage: b, Beccles, CT, d, Dundee, f, Fels 2, GI, GUI, GVI, GVIII, k, K, i, j, L, 01, (syn=0-1), (syn=O1), (syn=O-I), (syn=7), 02, 03, P3, P9a, PIO, Sab3, Sab5, SanIS, SanI7, SI, Taunton, ViI, (syn=ViI), 9, imSalmonella (1), N-I, N-5, N-IO, N-17, N-22, 11, 12, 16-19, 20.2, 36, 449C/C178, 966A/C259, a, B.A.O.R., e, G4, GUI, L, LP7, M, MG40, N-18, PSA68, P4, P9c, P22, (syn=P22), (syn=PLT22), (syn=PLT22), P22aI, P22-4, P22-7, P22-11, SNT-I, SNT-2, SP6, Villi, VilV, ViV, ViVI, ViVII, Worksop, Sj5, ε34, 1,37, 1(40), (syn=φI[40]), 1,422, 2, 2.5, 3b, 4, 5, 6,14(18), 8, 14(6,7), 10, 27, 28B, 30, 31, 32, 33, 34, 36, 37, 39, 1412, SNT-3, 7-11, 40.3, c, C236, C557, C625, C966N, g, GV, G5, GI 73, h, IRA, Jersey, MB78, P22-1, P22-3, P22-12, SabI, Sab2, Sab2, Sab4, SanI, San2, San3, San4, San6, San7, San8, San9, SanI3, SanI4, SanI6, SanI8, SanI9, San20, San21, San22, San23, San24, San25, San26, SasLI, SasL2, SasL3, SasL4, SasL5, SIBL, SII, ViII, φI, 1, 2, 3a, 3a1, 1010, Ym-Salmonella (1), N-4, SasL6 and 27.

Bacteria of the genus Serratia are infected by the following phage: A2P, PS20, SMB3, SMP, SMP5, SM2, V40, V56, ic, ϕPCP-3, ϕPCP-6, 3M, 10/1a, 20A, 34CC, 34H, 38T, 345G, 345P, 501B, SMB2, SMP2, BC, BT, CW2, CW3, CW4, CW5, Lt232, L2232, L34, L.228, SLP, SMPA, V.43, σ, φCWI, ϕCP6-1, ϕCP6-2, ϕCP6-5, 3T, 5, 8, 9F, 10/1, 20E, 32/6, 34B, 34CT, 34P, 37, 41, 56, 56D, 56P, 6OP, 61/6, 74/6, 76/4, 101/8900, 226, 227, 228, 229F, 286, 289, 290F, 512, 764a, 2847/10, 2847/1Oa, L.359 and SMBI.

Bacteria of the genus Shigella are infected by the following phage: Fsa, (syn=a), FSD2d, (syn=D2d), (syn=W2d), FSD2E, (syn=W2e), fv, F6, f7.8, H-Sh, PES, P90, SfII, Sh, SHm, SHrv, (syn=HIV), SHvi, (syn=HVI), SHVvm, (syn=HVIII), SKγ66, (syn=gamma 66), (syn=yββ), (syn=γ66b), SKm, (syn=SIIIb)5 (syn=UI), SKw, (syn=Siva), (syn=IV), SIC™, (syn=SIVA), (syn=IVA), SKvi, (syn=KVI), (syn=Svi), (syn=VI), SKvm, (syn=Svm), (syn=VIII), SKVΠIA, (syn=SvmA), (syn=VIIIA), STvi, STK, STx1, STxn, S66, W2, (syn=D2c), (syn=D20), φI, φIVb 3-SO-R, 8368-SO-R, F7, (syn=FS7), (syn=K29), FIO, (syn=FSIO), (syn=K31), I1, (syn=alfa), (syn=FSa), (syn=KI 8), (syn=α), I2, (syn=a), (syn=KI9), SG33, (syn=G35), (syn=SO-35/G), SG35, (syn=SO-55/G), SG3201, (syn=SO-3201/G), SHn, (syn=HII), SHv, (syn=SHV), SHx, SHX, SKn, (syn=K2), (syn=KII), (syn=Sn), (syn=SsII), (syn=II), SKrv, (syn=Sm), (syn=SsIV), (syn=IV), SK1Va, (syn=Swab), (syn=SsIVa), (syn=IVa), SKV, (syn=K4), (syn=KV), (syn=SV), (syn=SsV), (syn=V), SKx, (syn=K9), (syn=KX), (syn=SX), (syn=SsX), (syn=X), STV, (syn=T35), (syn=35-50-R), STvm, (syn=T8345), (syn=8345-SO-S-R), W1, (syn=D8), (syn=FSD8), W2a, (syn=D2A), (syn=FS2a), DD-2, Sf6, FSi, (syn=FI), SF6, (syn=F6), SG42, (syn=SO-42/G), SG3203, (syn=SO-3203/G), SKF12, (syn=SsF12), (syn=F12), (syn=F12), STn, (syn=1881-SO-R), γ66, (syn=gamma 66a), (syn=Ssγ66), φ2, BII, DDVII, (syn=DD7), FSD2b, (syn=W2B), FS2, (syn=F2), (syn=F2), FS4, (syn=F4), (syn=F4), FS5, (syn=F5), (syn=F5), FS9, (syn=F9), (syn=F9), FI I, P2-S0-S, SG36, (syn=SO-36/G), (syn=G36), SG3204, (syn=SO-3204/G), SG3244, (syn=SO-3244/G), SHi, (syn=HI), SHvrr, (syn=HVII), SHK, (syn=HIX), SHx1, SHxrr, (syn=HXn), SKI, KI, (syn=S1), (syn=SsI), SKVII, (syn=KVII), (syn=Svrr), (syn=SsVII), SKIX, (syn=KIX), (syn=S1x), (syn=SsIX), SKXII, (syn=KXII), (syn=Sxn), (syn=SsXII), STi, STffI, STrv, STVi, STvrr, S70, S206, U2-S0-S, 3210-SO-S, 3859-SO-S, 4020-SO-S, φ3, φ5, φ7, φ8, φ9, φIO, φI I, φI 3, φI4, φI8, SHm, (syn=Hπi), SHχi, (syn=HXt) and SKxI, (syn=KXI), (syn=Sχi), (syn=SsXI), (syn=XI).

Bacteria of the genus Staphylococcus are infected by the following phage: A, EW, K, Ph5, Ph9, PhIO, PhI3, PI, P2, P3, P4, P8, P9, PIO, RG, SB-i, (syn=Sb-I), S3K, Twort, ϕSK311, φ812, 06, 40, 58, 119, 130, 131, 200, 1623, STCI, (syn=stcI), STC2, (syn=stc2), 44AHJD, 68, ACI, AC2, A6″C″, A9″C″, b581, CA-I, CA-2, CA-3, CA-4, CA-5, DI I, L39x35, L54a, M42, NI, N2, N3, N4, N5, N7, N8, NIO, Ni I, N12, N13, N14, N16, Ph6, Phl2, Phl4, UC-18, U4, U15, SI, S2, S3, S4, S5, X2, Z1, φB5-2, φD, ω, 11, (syn=φI I), (syn=P11-M15), 15, 28, 28A, 29, 31, 31B, 37, 42D, (syn=P42D), 44A, 48, 51, 52, 52A, (syn=P52A), 52B, 53, 55, 69, 71, (syn=P71), 71A, 72, 75, 76, 77, 79, 80, 80α, 82, 82A, 83 A, 84, 85, 86, 88, 88A, 89, 90, 92, 95, 96, 102, 107, 108, 111, 129-26, 130, 130A, 155, 157, 157A, 165, 187, 275, 275A, 275B, 356, 456, 459, 471, 471A, 489, 581, 676, 898, 1139, 1154A, 1259, 1314, 1380, 1405, 1563, 2148, 2638A, 2638B, 2638C, 2731, 2792A, 2792B, 2818, 2835, 2848A, 3619, 5841, 12100, AC3, A8, AIO, A13, b594n, D, HK2, N9, N15, P52, P87, SI, S6, Z4, φRE, 3A, 3B, 3C, 6, 7, 16, 21, 42B, 42C, 42E, 44, 47, 47A5 47C, 51, 54, 54x1, 70, 73, 75, 78, 81, 82, 88, 93, 94, 101, 105, 110, 115, 129/16, 174, 594n, 1363/14, 2460 and mS-Staphylococcus (1).

Bacteria of the genus Streptococcus are infected by the following phage: EJ-I, NN-Streptococais (1), a, CI, FL0Ths, H39, Cp-I, Cp-5, Cp-7, Cp-9, Cp-IO, AT298, A5, aIO/JI, aIO/J2, aIO/J5, aIO/J9, A25, BTI I, b6, CAI, c20-I, c20-2, DP-I, Dp-4, DTI, ET42, eIO, FA101, FEThs, Fκ, FKKIOI, FKLIO, FKP74, FKH, FLOThs, FyIOI, fI, F10, F20140/76, g, GT-234, HB3, (syn=HB-3), HB-623, HB-746, M102, O1205, φ01205, PST, PO, PI, P2, P3, P5, P6, P8, P9, P9, P12, P13, P14, P49, P50, P51, P52, P53, P54, P55, P56, P57, P58, P59, P64, P67, P69, P71, P73, P75, P76, P77, P82, P83, P88, sc, sch, sf, SfII 1, (syn=SFiI I), (syn=φSFiII), (syn=ϕSfiI I), (syn=φSfiI I), sfiI9, (syn=SFiI9), (syn=φSFiI9), (syn=φSfiI9), Sfi21, (syn=SFi21), (syn=φSFi21), (syn=φSfi21), ST0, STX, st2, ST2, ST4, S3, (syn=φS3), s265, ℠17, φ42, ϕ57, φ80, φ81, φ82, φ83, φ84, φ85, φ86, φ87, φ88, φ89, φ90, φ91, φ92, φ93, φ94, φ95, φ96, φ97, φ98, φ99, φIOO, φIOI, φIO2, φ227, ϕ7201, ωI, ω2, ω3, ω4, ω5, ω6, ω8, ωIO, 1, 6, 9, 1OF, 12/12, 14, 17SR, 19S, 24, 50/33, 50/34, 55/14, 55/15, 70/35, 70/36, 71/ST15, 71/45, 71/46, 74F, 79/37, 79/38, 80/J4, 80/J9, 80/ST16, 80/15, 80/47, 80/48, 101, 103/39, 103/40, 121/41, 121/42, 123/43, 123/44, 124/44, 337/ST17 and mStreptococcus (34).

Bacteria of the genus Treponema are infected by the following phage: NN-Treponema (1).

Bacteria of the genus Vibrio are infected by the following phage: CTXϕ, fs, (syn=si), fs2, Ivpf5, VfI2, Vf33, VPIϕ, VSK, v6, 493, CP-TI, ET25, kappa, KI39, Labol, )XN-69P, OXN-86, O6N-21P, PB-I, P147, rp-1, SE3, VA-I, (syn=VcA-I), VcA-2, VPI, VP2, VP4, VP7, VP8, VP9, VPIO, VP17, VP18, VP19, X29, (syn=29 d'Herelle), t, ϕHAWI-1, ϕHAWI-2, ϕHAWI-3, ϕHAWI-4, ϕHAWI-5, ϕHAWI-6, ϕHAWI-7, XHAWI-8, ϕHAWI-9, ϕHAWI-10, ϕHCI-1, ϕHC1-2, ϕHC1-3, ϕHC1-4, ϕHC2-1, >HC2-2, ϕHC2-3, ϕHC2-4, ϕHC3-1, ϕHC3-2, ϕHC3-3, ϕHD1S-1, ϕHD1S-2, ϕHD2S-1, ϕHD2S-2, ϕHD2S-3, ϕHD2S-4, ϕHD2S-5, ϕHDO-1, ϕHDO-2, ϕHDO-3, ϕHDO-4, ϕHDO-5, ϕHDO-6, ϕKL-33, ϕKL-34, ϕKL-35, ϕKL-36, ϕKWH-2, ϕKWH-3, ϕKWH-4, ϕMARQ-1, ϕMARQ-2, ϕMARQ-3, ϕMOAT-1, ϕO139, ϕPEL1A-1, ϕPEL1A-2, ϕPEL8A-1, ϕPEL8A-2, ϕPEL8A-3, ϕPEL8C-1, ϕPEL8C-2, ϕPEL13A-1, ϕPEL13B-1, ϕPEL13B-2, ϕPEL13B-3, ϕPEL13B-4, ϕPEL13B-5, ϕPEL13B-6, ϕPEL13B-7, ϕPEL13B-8, ϕPEL13B-9, ϕPEL13B-10, φVP143, φVP253, ϕ16, φI38, 1-II, 5, 13, 14, 16, 24, 32, 493, 6214, 7050, 7227, II, (syn=group II), (syn==φ2), V, VIII, ˜m-Vibrio (13), KVP20, KVP40, nt-1, O6N-22P, P68, eI, e2, e3, e4, e5, FK, G, I, K, nt-6, NI, N2, N3, N4, N5, O6N-34P, OXN-72P, OXN-85P, OXN-100P, P, Ph-I, PL163/10, Q, S, T, φ92, 1-9, 37, 51, 57, 70A-8, 72A-4, 72A-10, 110A-4, 333, 4996, I (syn=group I), III (syn=group III), VI, (syn=A-Saratov), VII, IX, X, HN-Vibrio (6), pAI, 7, 7-8, 70A-2, 71A-6, 72A-5, 72A-8, 108A-10, 109A-6, 109A-8, IIOA-1, IIOA-5, IIOA-7, by-1, OXN-52P, P13, P38, P53, P65, P108, Pill, TP13 VP3, VP6, VP12, VP13, 70A-3, 70A-4, 70A-10, 72A-1, 108A-3, 109-B1, 110A-2, 149, (syn=T149), IV, (syn=group IV), NN-Vibrio (22), VPS, VPII, VP15, VP16, αI, α2, α3a, α3b, 353B and HN-Vibrio (7).

Bacteria of the genus Yersinia are infected by the following phage: H, H-I, H-2, H-3, H-4, Lucas 110, Lucas 303, Lucas 404, YerA3, YerA7, YerA20, YerA41, 3/M64-76, 5/G394-76, 6/C753-76, 8/C239-76, 9/F18167, 1701, 1710, PST, 1/F2852-76, D'Herelle, EV, H, Kotljarova, PTB, R, Y, YerA41, φYerO3-12, 3, 4/01324-76, 7/F783-76, 903, 1/M6176 and Yer2AT.

More preferably, the bacteriophage is selected in the group consisting of Salmonella virus SKML39, Shigella virus AG3, Dickeya virus Limestone, Dickeya virus RC2014, Escherichia virus CBA120, Escherichia virus PhaxI, Salmonella virus 38, Salmonella virus Det7, Salmonella virus GG32, Salmonella virus PM10, Salmonella virus SFP10, Salmonella virus SH19, Salmonella virus SJ3, Escherichia virus ECML4, Salmonella virus Marshall, Salmonella virus Maynard, Salmonella virus SJ2, Salmonella virus STML131, Salmonella virus ViI, Erwinia virus Ea2809, Klebsiella virus 0507KN21, Serratia virus IME250, Serratia virus MAM1, Campylobacter virus CP21, Campylobacter virus CP220, Campylobacter virus CPt10, Campylobacter virus IBB35, Campylobacter virus CP81, Campylobacter virus CP30A, Campylobacter virus CPX, Campylobacter virus NCTC12673, Erwinia virus Ea214, Erwinia virus M7, Escherichia virus AYO145A, Escherichia virus EC6, Escherichia virus HY02, Escherichia virus JH2, Escherichia virus TP1, Escherichia virus VpaE1, Escherichia virus wV8, Salmonella virus FelixO1, Salmonella virus HB2014, Salmonella virus Mushroom, Salmonella virus UAB87, Citrobacter virus Moogle, Citrobacter virus Mordin, Escherichia virus SUSP1, Escherichia virus SUSP2, Aeromonas virus phiO18P, Haemophilus virus HP1, Haemophilus virus HP2, Pasteurella virus F108, Vibrio virus KI39, Vibrio virus Kappa, Burkholderia virus phi52237, Burkholderia virus phiE122, Burkholderia virus phiE202, Escherichia virus 186, Escherichia virus P4, Escherichia virus P2, Escherichia virus Wphi, Mannheimia virus PHL101, Pseudomonas virus phiCTX, Ralstonia virus RSA1, Salmonella virus Fels2, Salmonella virus PsP3, Salmonella virus SopEphi, Yersinia virus L413C, Staphylococcus virus G1, Staphylococcus virus G15, Staphylococcus virus JD7, Staphylococcus virus K, Staphylococcus virus MCE2014, Staphylococcus virus P108, Staphylococcus virus Rodi, Staphylococcus virus S253, Staphylococcus virus S25-4, Staphylococcus virus SA12, Listeria virus A511, Listeria virus P100, Staphylococcus virus Remus, Staphylococcus virus SA11, Staphylococcus virus Stau2, Bacillus virus Camphawk, Bacillus virus SPO1, Bacillus virus BCP78, Bacillus virus TsarBomba, Staphylococcus virus Twort, Enterococcus virus phiEC24C, Lactobacillus virus Lb338-1, Lactobacillus virus LP65, Enterobacter virus PG7, Escherichia virus CC31, Klebsiella virus JD18, Klebsiella virus PKO111, Escherichia virus Bp7, Escherichia virus IME08, Escherichia virus JS10, Escherichia virus JS98, Escherichia virus QL01, Escherichia virus VR5, Enterobacter virus Eap3, Klebsiella virus KP15, Klebsiella virus KP27, Klebsiella virus Matisse, Klebsiella virus Miro, Citrobacter virus Merlin, Citrobacter virus Moon, Escherichia virus JSE, Escherichia virus phi1, Escherichia virus RB49, Escherichia virus HX01, Escherichia virus J509, Escherichia virus RB69, Shigella virus UTAM, Salmonella virus S16, Salmonella virus STML198, Vibrio virus KVP40, Vibrio virus nt1, Vibrio virus ValKK3, Escherichia virus VR7, Escherichia virus VR20, Escherichia virus VR25, Escherichia virus VR26, Shigella virus SP18, Escherichia virus AR1, Escherichia virus C40, Escherichia virus E112, Escherichia virus ECML134, Escherichia virus HY01, Escherichia virus Ime09, Escherichia virus RB3, Escherichia virus RB14, Escherichia virus T4, Shigella virus Pss1, Shigella virus ShfI2, Yersinia virus D1, Yersinia virus PST, Acinetobacter virus 133, Aeromonas virus 65, Aeromonas virus Aeh1, Escherichia virus RB16, Escherichia virus RB32, Escherichia virus RB43, Pseudomonas virus 42, Cronobacter virus CR3, Cronobacter virus CR8, Cronobacter virus CR9, Cronobacter virus PBES02, Pectobacterium virus phiTE, Cronobacter virus GAP31, Escherichia virus 4MG, Salmonella virus SE1, Salmonella virus SSE121, Escherichia virus FFH2, Escherichia virus FV3, Escherichia virus JES2013, Escherichia virus V5, Brevibacillus virus Abouo, Brevibacillus virus Davies, Bacillus virus Agate, Bacillus virus Bobb, Bacillus virus Bp8pC, Erwinia virus Deimos, Erwinia virus Ea35-70, Erwinia virus RAY, Erwinia virus Simmy50, Erwinia virus SpecialG, Acinetobacter virus AB1, Acinetobacter virus AB2, Acinetobacter virus AbC62, Acinetobacter virus AP22, Arthrobacter virus ArV1, Arthrobacter virus Trina, Bacillus virus AvesoBmore, Bacillus virus B4, Bacillus virus Bigbertha, Bacillus virus Riley, Bacillus virus Spock, Bacillus virus Troll, Bacillus virus Bastille, Bacillus virus CAM003, Bacillus virus Bc431, Bacillus virus Bcp1, Bacillus virus BCP82, Bacillus virus BM15, Bacillus virus Deepblue, Bacillus virus JBP901, Burkholderia virus Bcep1, Burkholderia virus Bcep43, Burkholderia virus Bcep781, Burkholderia virus BcepNY3, Xanthomonas virus OP2, Burkholderia virus BcepMu, Burkholderia virus phiE255, Aeromonas virus 44RR2, Mycobacterium virus Alice, Mycobacterium virus Bxz1, Mycobacterium virus Dandelion, Mycobacterium virus HyRo, Mycobacterium virus 13, Mycobacterium virus Nappy, Mycobacterium virus Sebata, Clostridium virus phiC2, Clostridium virus phiCD27, Clostridium virus phiCD119, Bacillus virus CP51, Bacillus virus JL, Bacillus virus Shanette, Escherichia virus CVM10, Escherichia virus ep3, Erwinia virus Asesino, Erwinia virus EaH2, Pseudomonas virus EL, Halomonas virus HAP1, Vibrio virus VP882, Brevibacillus virus Jimmer, Brevibacillus virus Osiris, Pseudomonas virus Ab03, Pseudomonas virus KPP10, Pseudomonas virus PAKP3, Sinorhizobium virus M7, Sinorhizobium virus M12, Sinorhizobium virus N3, Erwinia virus Machina, Arthrobacter virus Brent, Arthrobacter virus Jawnski, Arthrobacter virus Martha, Arthrobacter virus Sonny, Edwardsiella virus MSW3, Edwardsiella virus PEi21, Escherichia virus Mu, Shigella virus SfMu, Halobacterium virus phiH, Bacillus virus Grass, Bacillus virus NIT1, Bacillus virus SPG24, Aeromonas virus 43, Escherichia virus P1, Pseudomonas virus CAb1, Pseudomonas virus CAb02, Pseudomonas virus JG004, Pseudomonas virus PAKP1, Pseudomonas virus PAKP4, Pseudomonas virus PaP1, Burkholderia virus BcepF1, Pseudomonas virus 141, Pseudomonas virus Ab28, Pseudomonas virus DL60, Pseudomonas virus DL68, Pseudomonas virus F8, Pseudomonas virus JG024, Pseudomonas virus KPP12, Pseudomonas virus LBL3, Pseudomonas virus LMA2, Pseudomonas virus PB1, Pseudomonas virus SN, Pseudomonas virus PA7, Pseudomonas virus phiKZ, Rhizobium virus RHEph4, Ralstonia virus RSF1, Ralstonia virus RSL2, Ralstonia virus RSL1, Aeromonas virus 25, Aeromonas virus 31, Aeromonas virus Aes12, Aeromonas virus Aes508, Aeromonas virus AS4, Stenotrophomonas virus IME13, Staphylococcus virus IPLAC1C, Staphylococcus virus SEP1, Salmonella virus SPN3US, Bacillus virus 1, Geobacillus virus GBSV1, Yersinia virus R1RT, Yersinia virus TG1, Bacillus virus G, Bacillus virus PBS1, Microcystis virus Ma-LMM01, Vibrio virus MAR, Vibrio virus VHML, Vibrio virus VP585, Bacillus virus BPS13, Bacillus virus Hakuna, Bacillus virus Megatron, Bacillus virus WPh, Acinetobacter virus AB3, Acinetobacter virus Abp1, Acinetobacter virus Fri1, Acinetobacter virus IME200, Acinetobacter virus PD6A3, Acinetobacter virus PDAB9, Acinetobacter virus phiAB1, Escherichia virus K30, Klebsiella virus K5, Klebsiella virus KI1, Klebsiella virus Kp1, Klebsiella virus KP32, Klebsiella virus KpV289, Klebsiella virus F19, Klebsiella virus K244, Klebsiella virus Kp2, Klebsiella virus KP34, Klebsiella virus KpV41, Klebsiella virus KpV71, Klebsiella virus KpV475, Klebsiella virus SU503, Klebsiella virus SU552A, Pantoea virus Limelight, Pantoea virus Limezero, Pseudomonas virus LKA1, Pseudomonas virus phiKMV, Xanthomonas virus f20, Xanthomonas virus f30, Xylella virus Prado, Erwinia virus Era103, Escherichia virus K5, Escherichia virus KI-5, Escherichia virus KIE, Salmonella virus SP6, Escherichia virus T7, Kluyvera virus Kvp1, Pseudomonas virus gh1, Prochlorococcus virus PSSP7, Synechococcus virus P60, Synechococcus virus SynS, Streptococcus virus Cp1, Streptococcus virus Cp7, Staphylococcus virus 44AHJD, Streptococcus virus C1, Bacillus virus B103, Bacillus virus GA1, Bacillus virus phi29, Kurthia virus 6, Actinomyces virus Av1, Mycoplasma virus P1, Escherichia virus 24B, Escherichia virus 933W, Escherichia virus Min27, Escherichia virus PA28, Escherichia virus Stx2 II, Shigella virus 7502Stx, Shigella virus POCJ13, Escherichia virus 191, Escherichia virus PA2, Escherichia virus TL2011, Shigella virus VASD, Burkholderia virus Bcep22, Burkholderia virus BcepiI02, Burkholderia virus BcepmigI, Burkholderia virus DC1, Bordetella virus BPP1, Burkholderia virus BcepC6B, Cellulophaga virus Cba41, Cellulophaga virus Cba172, Dinoroseobacter virus DFL12, Erwinia virus Ea9-2, Erwinia virus Frozen, Escherichia virus phiV10, Salmonella virus Epsilon15, Salmonella virus SPN1S, Pseudomonas virus F116, Pseudomonas virus H66, Escherichia virus APECS, Escherichia virus APEC7, Escherichia virus Bp4, Escherichia virus EC1UPM, Escherichia virus ECBP1, Escherichia virus G7C, Escherichia virus IME11, Shigella virus Sb1, Achromobacter virus Axp3, Achromobacter virus JWAlpha, Edwardsiella virus KF1, Pseudomonas virus KPP25, Pseudomonas virus R18, Pseudomonas virus Ab09, Pseudomonas virus LIT1, Pseudomonas virus PA26, Pseudomonas virus Ab22, Pseudomonas virus CHU, Pseudomonas virus LUZ24, Pseudomonas virus PAA2, Pseudomonas virus PaP3, Pseudomonas virus PaP4, Pseudomonas virus TL, Pseudomonas virus KPP21, Pseudomonas virus LUZ7, Escherichia virus N4, Salmonella virus 9NA, Salmonella virus SP069, Salmonella virus BTP1, Salmonella virus HK620, Salmonella virus P22, Salmonella virus ST64T, Shigella virus Sf6, Bacillus virus Page, Bacillus virus Palmer, Bacillus virus Pascal, Bacillus virus Pony, Bacillus virus Pookie, Escherichia virus 172-1, Escherichia virus ECB2, Escherichia virus NJ01, Escherichia virus phiEco32, Escherichia virus Septima11, Escherichia virus SU10, Brucella virus Pr, Brucella virus Tb, Escherichia virus Pollock, Salmonella virus FSL SP-058, Salmonella virus FSL SP-076, Helicobacter virus 1961P, Helicobacter virus KHP30, Helicobacter virus KHP40, Hamiltonella virus APSE1, Lactococcus virus KSY1, Phormidium virus WMP3, Phormidium virus WMP4, Pseudomonas virus 119X, Roseobacter virus SIO1, Vibrio virus VpV262, Vibrio virus VC8, Vibrio virus VP2, Vibrio virus VP5, Streptomyces virus Amela, Streptomyces virus phiCAM, Streptomyces virus Aaronocolus, Streptomyces virus Caliburn, Streptomyces virus Danzina, Streptomyces virus Hydra, Streptomyces virus Izzy, Streptomyces virus Lannister, Streptomyces virus Lika, Streptomyces virus Sujidade, Streptomyces virus Zemlya, Streptomyces virus ELB20, Streptomyces virus R4, Streptomyces virus phiHau3, Mycobacterium virus Acadian, Mycobacterium virus Baee, Mycobacterium virus Reprobate, Mycobacterium virus Adawi, Mycobacterium virus Bane1, Mycobacterium virus BrownCNA, Mycobacterium virus Chrisnmich, Mycobacterium virus Cooper, Mycobacterium virus JAMaL, Mycobacterium virus Nigel, Mycobacterium virus Stinger, Mycobacterium virus Vincenzo, Mycobacterium virus Zemanar, Mycobacterium virus Apizium, Mycobacterium virus Manad, Mycobacterium virus Oline, Mycobacterium virus Osmaximus, Mycobacterium virus Pg1, Mycobacterium virus Soto, Mycobacterium virus Suffolk, Mycobacterium virus Athena, Mycobacterium virus Bernardo, Mycobacterium virus Gadjet, Mycobacterium virus Pipefish, Mycobacterium virus Godines, Mycobacterium virus Rosebush, Mycobacterium virus Babsiella, Mycobacterium virus Brujita, Mycobacterium virus Che9c, Mycobacterium virus Sbash, Mycobacterium virus Hawkeye, Mycobacterium virus Plot, Salmonella virus AG11, Salmonella virus Ent1, Salmonella virus f18SE, Salmonella virus Jersey, Salmonella virus L13, Salmonella virus LSPA1, Salmonella virus SE2, Salmonella virus SETP3, Salmonella virus SETP7, Salmonella virus SETP13, Salmonella virus SP101, Salmonella virus SS3e, Salmonella virus wksI3, Escherichia virus KIG, Escherichia virus KIH, Escherichia virus K1ind1, Escherichia virus K1ind2, Salmonella virus SP31, Leuconostoc virus Lmd1, Leuconostoc virus LN03, Leuconostoc virus LN04, Leuconostoc virus LN12, Leuconostoc virus LN6B, Leuconostoc virus P793, Leuconostoc virus 1A4, Leuconostoc virus Ln8, Leuconostoc virus Ln9, Leuconostoc virus LN25, Leuconostoc virus LN34, Leuconostoc virus LNTR3, Mycobacterium virus Bongo, Mycobacterium virus Rey, Mycobacterium virus Butters, Mycobacterium virus Michelle, Mycobacterium virus Charlie, Mycobacterium virus Pipsqueaks, Mycobacterium virus Xeno, Mycobacterium virus Panchino, Mycobacterium virus Phrann, Mycobacterium virus Redi, Mycobacterium virus Skinnyp, Gordonia virus BaxterFox, Gordonia virus Yeezy, Gordonia virus Kita, Gordonia virus Zirinka, Gorrdonia virus Nymphadora, Mycobacterium virus Bignuz, Mycobacterium virus Brusacoram, Mycobacterium virus Donovan, Mycobacterium virus Fishburne, Mycobacterium virus Jebeks, Mycobacterium virus Malithi, Mycobacterium virus Phayonce, Enterobacter virus F20, Klebsiella virus 1513, Klebsiella virus KLPN1, Klebsiella virus KP36, Klebsiella virus PKP126, Klebsiella virus Sushi, Escherichia virus AHP42, Escherichia virus AHS24, Escherichia virus AKS96, Escherichia virus C119, Escherichia virus E41c, Escherichia virus Eb49, Escherichia virus Jk06, Escherichia virus KP26, Escherichia virus Rogue1, Escherichia virus ACGM12, Escherichia virus Rtp, Escherichia virus ADB2, Escherichia virus JMPW1, Escherichia virus JMPW2, Escherichia virus T1, Shigella virus PSf2, Shigella virus ShfI1, Citrobacter virus Stevie, Escherichia virus TLS, Salmonella virus SP126, Cronobacter virus Esp2949-1, Pseudomonas virus Ab18, Pseudomonas virus Ab19, Pseudomonas virus PaMx11, Arthrobacter virus Amigo, Propionibacterium virus Anatole, Propionibacterium virus B3, Bacillus virus Andromeda, Bacillus virus Blastoid, Bacillus virus Curly, Bacillus virus Eoghan, Bacillus virus Finn, Bacillus virus Glittering, Bacillus virus Riggi, Bacillus virus Taylor, Gordonia virus Attis, Mycobacterium virus Barnyard, Mycobacterium virus Konstantine, Mycobacterium virus Predator, Mycobacterium virus Bernal13, Staphylococcus virus 13, Staphylococcus virus 77, Staphylococcus virus 108PVL, Mycobacterium virus Bron, Mycobacterium virus Faith1, Mycobacterium virus Joedirt, Mycobacterium virus Rumpelstiltskin, Lactococcus virus bIL67, Lactococcus virus c2, Lactobacillus virus c5, Lactobacillus virus Ld3, Lactobacillus virus Ld17, Lactobacillus virus Ld25A, Lactobacillus virus LLKu, Lactobacillus virus phiLdb, Cellulophaga virus Cba121, Cellulophaga virus Cba171, Cellulophaga virus Cba181, Cellulophaga virus ST, Bacillus virus 250, Bacillus virus IEBH, Mycobacterium virus Ardmore, Mycobacterium virus Avani, Mycobacterium virus Boomer, Mycobacterium virus Che8, Mycobacterium virus Che9d, Mycobacterium virus Deadp, Mycobacterium virus Dlane, Mycobacterium virus Dorothy, Mycobacterium virus Dotproduct, Mycobacterium virus Drago, Mycobacterium virus Fruitloop, Mycobacterium virus Gumbie, Mycobacterium virus lbhubesi, Mycobacterium virus Llij, Mycobacterium virus Mozy, Mycobacterium virus Mutaforma13, Mycobacterium virus Pacc40, Mycobacterium virus PMC, Mycobacterium virus Ramsey, Mycobacterium virus Rockyhorror, Mycobacterium virus SG4, Mycobacterium virus Shaunal, Mycobacterium virus Shilan, Mycobacterium virus Spartacus, Mycobacterium virus Taj, Mycobacterium virus Tweety, Mycobacterium virus Wee, Mycobacterium virus Yoshi, Salmonella virus Chi, Salmonella virus FSLSP030, Salmonella virus FSLSP088, Salmonella virus iEPS5, Salmonella virus SPN19, Mycobacterium virus 244, Mycobacterium virus Bask21, Mycobacterium virus CJW1, Mycobacterium virus Eureka, Mycobacterium virus Kostya, Mycobacterium virus Porky, Mycobacterium virus Pumpkin, Mycobacterium virus Sirduracell, Mycobacterium virus Toto, Mycobacterium virus Corndog, Mycobacterium virus Firecracker, Rhodobacter virus RcCronus, Pseudomonas virus D3112, Pseudomonas virus DMS3, Pseudomonas virus FHA0480, Pseudomonas virus LPB1, Pseudomonas virus MP22, Pseudomonas virus MP29, Pseudomonas virus MP38, Pseudomonas virus PA1KOR, Pseudomonas virus D3, Pseudomonas virus PMG1, Arthrobacter virus Decurro, Gordonia virus Demosthenes, Gordonia virus Katyusha, Gordonia virus Kvothe, Propionibacterium virus B22, Propionibacterium virus Doucette, Propionibacterium virus E6, Propionibacterium virus G4, Burkholderia virus phi6442, Burkholderia virus phi1026b, Burkholderia virus phiE125, Edwardsiella virus eiAU, Mycobacterium virus Ff47, Mycobacterium virus Muddy, Mycobacterium virus Gaia, Mycobacterium virus Giles, Arthrobacter virus Captnmurica, Arthrobacter virus Gordon, Gordonia virus GordTnk2, Paenibacillus virus Harrison, Escherichia virus EK99P1, Escherichia virus HK578, Escherichia virus JL1, Escherichia virus SSL2009a, Escherichia virus YD2008s, Shigella virus EP23, Sodalis virus SO1, Escherichia virus HK022, Escherichia virus HK75, Escherichia virus HK97, Escherichia virus HK106, Escherichia virus HK446, Escherichia virus HK542, Escherichia virus HK544, Escherichia virus HK633, Escherichia virus mEp234, Escherichia virus mEp235, Escherichia virus mEpX1, Escherichia virus mEpX2, Escherichia virus mEp043, Escherichia virus mEp213, Escherichia virus mEp237, Escherichia virus mEp390, Escherichia virus mEp460, Escherichia virus mEp505, Escherichia virus mEp506, Brevibacillus virus Jenst, Achromobacter virus 83-24, Achromobacter virus JWX, Arthrobacter virus Kellezzio, Arthrobacter virus Kitkat, Arthrobacter virus Bennie, Arthrobacter virus DrRobert, Arthrobacter virus Glenn, Arthrobacter virus HunterDalle, Arthrobacter virus Joann, Arthrobacter virus Korra, Arthrobacter virus Preamble, Arthrobacter virus Pumancara, Arthrobacter virus Wayne, Mycobacterium virus Alma, Mycobacterium virus Arturo, Mycobacterium virus Astro, Mycobacterium virus Backyardigan, Mycobacterium virus BBPiebs31, Mycobacterium virus Benedict, Mycobacterium virus Bethlehem, Mycobacterium virus Billknuckles, Mycobacterium virus Bruns, Mycobacterium virus Bxb1, Mycobacterium virus Bxz2, Mycobacterium virus Che12, Mycobacterium virus Cuco, Mycobacterium virus D29, Mycobacterium virus Doom, Mycobacterium virus Ericb, Mycobacterium virus Euphoria, Mycobacterium virus George, Mycobacterium virus Gladiator, Mycobacterium virus Goose, Mycobacterium virus Hammer, Mycobacterium virus Heldan, Mycobacterium virus Jasper, Mycobacterium virus JC27, Mycobacterium virus Jeffabunny, Mycobacterium virus JHC117, Mycobacterium virus KBG, Mycobacterium virus Kssjeb, Mycobacterium virus Kugel, Mycobacterium virus L5, Mycobacterium virus Lesedi, Mycobacterium virus LHTSCC, Mycobacterium virus lockley, Mycobacterium virus Marcell, Mycobacterium virus Microwolf, Mycobacterium virus Mrgordo, Mycobacterium virus Museum, Mycobacterium virus Nepal, Mycobacterium virus Packman, Mycobacterium virus Peaches, Mycobacterium virus Perseus, Mycobacterium virus Pukovnik, Mycobacterium virus Rebeuca, Mycobacterium virus Redrock, Mycobacterium virus Ridgecb, Mycobacterium virus Rockstar, Mycobacterium virus Saintus, Mycobacterium virus Skipole, Mycobacterium virus Solon, Mycobacterium virus Switzer, Mycobacterium virus SWU1, Mycobacterium virus Ta17a, Mycobacterium virus Tiger, Mycobacterium virus Timshel, Mycobacterium virus Trixie, Mycobacterium virus Turbido, Mycobacterium virus Twister, Mycobacterium virus U2, Mycobacterium virus Violet, Mycobacterium virus Wonder, Escherichia virus DE3, Escherichia virus HK629, Escherichia virus HK630, Escherichia virus Lambda, Arthrobacter virus Laroye, Mycobacterium virus Halo, Mycobacterium virus Liefie, Mycobacterium virus Marvin, Mycobacterium virus Mosmoris, Arthrobacter virus Circum, Arthrobacter virus Mudcat, Escherichia virus N15, Escherichia virus 9g, Escherichia virus JenKI, Escherichia virus JenP1, Escherichia virus JenP2, Pseudomonas virus NP1, Pseudomonas virus PaMx25, Mycobacterium virus Baka, Mycobacterium virus Courthouse, Mycobacterium virus Littlee, Mycobacterium virus Omega, Mycobacterium virus Optimus, Mycobacterium virus Thibault, Polaribacter virus P12002L, Polaribacter virus P12002S, Nonlabens virus P12024L, Nonlabens virus P12024S, Thermus virus P23-45, Thermus virus P74-26, Listeria virus LP26, Listeria virus LP37, Listeria virus LP110, Listeria virus LP114, Listeria virus P70, Propionibacterium virus ATCC29399BC, Propionibacterium virus ATCC29399BT, Propionibacterium virus Attacne, Propionibacterium virus Keiki, Propionibacterium virus Kubed, Propionibacterium virus Lauchelly, Propionibacterium virus MrAK, Propionibacterium virus Ouroboros, Propionibacterium virus P91, Propionibacterium virus P105, Propionibacterium virus P144, Propionibacterium virus P1001, Propionibacterium virus P1.1, Propionibacterium virus P100A, Propionibacterium virus P100D, Propionibacterium virus P101A, Propionibacterium virus P104A, Propionibacterium virus PA6, Propionibacterium virus Pacnes201215, Propionibacterium virus PAD20, Propionibacterium virus PAS50, Propionibacterium virus PHLOO9M11, Propionibacterium virus PHL025M00, Propionibacterium virus PHL037M02, Propionibacterium virus PHL041M10, Propionibacterium virus PHL060L00, Propionibacterium virus PHL067M01, Propionibacterium virus PHL070N00, Propionibacterium virus PHL071N05, Propionibacterium virus PHL082M03, Propionibacterium virus PHL092M00, Propionibacterium virus PHL095N00, Propionibacterium virus PHL111M01, Propionibacterium virus PHL112N00, Propionibacterium virus PHL113M01, Propionibacterium virus PHL114L00, Propionibacterium virus PHL116M00, Propionibacterium virus PHL117M00, Propionibacterium virus PHL117M01, Propionibacterium virus PHL132N00, Propionibacterium virus PHL141N00, Propionibacterium virus PHL151M00, Propionibacterium virus PHL151N00, Propionibacterium virus PHL152M00, Propionibacterium virus PHL163M00, Propionibacterium virus PHL171M01, Propionibacterium virus PHL179M00, Propionibacterium virus PHL194M00, Propionibacterium virus PHL199M00, Propionibacterium virus PHL301M00, Propionibacterium virus PHL308M00, Propionibacterium virus Pirate, Propionibacterium virus Procrass1, Propionibacterium virus SKKY, Propionibacterium virus Solid, Propionibacterium virus Stormborn, Propionibacterium virus Wizzo, Pseudomonas virus PaMx28, Pseudomonas virus PaMx74, Mycobacterium virus Patience, Mycobacterium virus PBI1, Rhodococcus virus Pepy6, Rhodococcus virus Poco6, Propionibacterium virus PFR1, Streptomyces virus phiBT1, Streptomyces virus phiC31, Streptomyces virus TG1, Caulobacter virus Karma, Caulobacter virus Magneto, Caulobacter virus phiCbK, Caulobacter virus Rogue, Caulobacter virus Swift, Staphylococcus virus 11, Staphylococcus virus 29, Staphylococcus virus 37, Staphylococcus virus 53, Staphylococcus virus 55, Staphylococcus virus 69, Staphylococcus virus 71, Staphylococcus virus 80, Staphylococcus virus 85, Staphylococcus virus 88, Staphylococcus virus 92, Staphylococcus virus 96, Staphylococcus virus 187, Staphylococcus virus 52a, Staphylococcus virus 80alpha, Staphylococcus virus CNPH82, Staphylococcus virus EW, Staphylococcus virus IPLA5, Staphylococcus virus IPLA7, Staphylococcus virus IPLA88, Staphylococcus virus PH15, Staphylococcus virus phiETA, Staphylococcus virus phiETA2, Staphylococcus virus phiETA3, Staphylococcus virus phiMR11, Staphylococcus virus phiMR25, Staphylococcus virus phiNM1, Staphylococcus virus phiNM2, Staphylococcus virus phiNM4, Staphylococcus virus SAP26, Staphylococcus virus X2, Enterococcus virus FL1, Enterococcus virus FL2, Enterococcus virus FL3, Lactobacillus virus ATCC8014, Lactobacillus virus phiJL1, Pediococcus virus cIP1, Aeromonas virus pIS4A, Listeria virus LP302, Listeria virus PSA, Methanobacterium virus psiM1, Roseobacter virus RDJL1, Roseobacter virus RDJL2, Rhodococcus virus RER2, Enterococcus virus BC611, Enterococcus virus IMEEF1, Enterococcus virus SAP6, Enterococcus virus VD13, Streptococcus virus SPQS1, Mycobacterium virus Papyrus, Mycobacterium virus Send513, Burkholderia virus KL1, Pseudomonas virus 73, Pseudomonas virus Ab26, Pseudomonas virus Kakheti25, Escherichia virus Cajan, Escherichia virus Seurat, Staphylococcus virus SEP9, Staphylococcus virus Sextaec, Streptococcus virus 858, Streptococcus virus 2972, Streptococcus virus ALQ132, Streptococcus virus 01205, Streptococcus virus Sfi11, Streptococcus virus 7201, Streptococcus virus DT1, Streptococcus virus phiAbc2, Streptococcus virus Sfi19, Streptococcus virus Sfi21, Paenibacillus virus Diva, Paenibacillus virus Hb10c2, Paenibacillus virus Rani, Paenibacillus virus Shelly, Paenibacillus virus Sitara, Paenibacillus virus Willow, Lactococcus virus 712, Lactococcus virus ASCC191, Lactococcus virus ASCC273, Lactococcus virus ASCC281, Lactococcus virus ASCC465, Lactococcus virus ASCC532, Lactococcus virus Bibb29, Lactococcus virus bIL170, Lactococcus virus CB13, Lactococcus virus CB14, Lactococcus virus CB19, Lactococcus virus CB20, Lactococcus virus jj50, Lactococcus virus P2, Lactococcus virus P008, Lactococcus virus ski, Lactococcus virus SI4, Bacillus virus Slash, Bacillus virus Stahl, Bacillus virus Staley, Bacillus virus Stills, Gordonia virus Bachita, Gordonia virus ClubL, Gordonia virus OneUp, Gordonia virus Smoothie, Gordonia virus Soups, Bacillus virus SPbeta, Vibrio virus MAR10, Vibrio virus SSP002, Escherichia virus AKFV33, Escherichia virus BF23, Escherichia virus DT57C, Escherichia virus EPS7, Escherichia virus FFH1, Escherichia virus H8, Escherichia virus slur09, Escherichia virus T5, Salmonella virus 118970sal2, Salmonella virus Shivani, Salmonella virus SPC35, Salmonella virus Stitch, Arthrobacter virus Tank, Tsukamurella virus TIN2, Tsukamurella virus TIN3, Tsukamurella virus TIN4, Rhodobacter virus RcSpartan, Rhodobacter virus RcTitan, Mycobacterium virus Anaya, Mycobacterium virus Angelica, Mycobacterium virus Crimd, Mycobacterium virus Fionnbarth, Mycobacterium virus Jaws, Mycobacterium virus Larva, Mycobacterium virus Macncheese, Mycobacterium virus Pixie, Mycobacterium virus TM4, Bacillus virus BMBtp2, Bacillus virus TP21, Geobacillus virus Tp84, Staphylococcus virus 47, Staphylococcus virus 3a, Staphylococcus virus 42e, Staphylococcus virus IPLA35, Staphylococcus virus phi12, Staphylococcus virus phiSLT, Mycobacterium virus 32HC, Rhodococcus virus RGL3, Paenibacillus virus Vegas, Gordonia virus Vendetta, Bacillus virus Wbeta, Mycobacterium virus Wildcat, Gordonia virus Twister6, Gordonia virus Wizard, Gordonia virus Hotorobo, Gordonia virus Monty, Gordonia virus Woes, Xanthomonas virus CP1, Xanthomonas virus OP1, Xanthomonas virus phiI7, Xanthomonas virus Xop411, Xanthomonas virus Xp10, Streptomyces virus TP1604, Streptomyces virus YDN12, Alphaproteobacteria virus phiJI001, Pseudomonas virus LKO4, Pseudomonas virus M6, Pseudomonas virus MP1412, Pseudomonas virus PAE1, Pseudomonas virus Yua, Pseudoalteromonas virus PM2, Pseudomonas virus phi6, Pseudomonas virus phi8, Pseudomonas virus phi12, Pseudomonas virus phi13, Pseudomonas virus phi2954, Pseudomonas virus phiNN, Pseudomonas virus phiYY, Vibrio virus fs1, Vibrio virus VGJ, Ralstonia virus RS603, Ralstonia virus RSM1, Ralstonia virus RSM3, Escherichia virus M13, Escherichia virus 122, Salmonella virus IKe, Acholeplasma virus L51, Vibrio virus fs2, Vibrio virus VFJ, Escherichia virus If1, Propionibacterium virus B5, Pseudomonas virus Pf1, Pseudomonas virus Pf3, Ralstonia virus PE226, Ralstonia virus RSS1, Spiroplasma virus SVTS2, Stenotrophomonas virus PSH1, Stenotrophomonas virus SMA6, Stenotrophomonas virus SMA7, Stenotrophomonas virus SMA9, Vibrio virus CTXphi, Vibrio virus KSF1, Vibrio virus VCY, Vibrio virus Vf33, Vibrio virus VfO3K6, Xanthomonas virus Cf1c, Spiroplasma virus C74, Spiroplasma virus R8A2B, Spiroplasma virus SkV1CR23x, Escherichia virus FI, Escherichia virus Qbeta, Escherichia virus BZ13, Escherichia virus MS2, Escherichia virus alpha3, Escherichia virus 1D21, Escherichia virus 1D32, Escherichia virus 1D62, Escherichia virus NC28, Escherichia virus NC29, Escherichia virus NC35, Escherichia virus phiK, Escherichia virus St1, Escherichia virus WA45, Escherichia virus G4, Escherichia virus ID52, Escherichia virus Talmos, Escherichia virus phiX174, Bdellovibrio virus MAC1, Bdellovibrio virus MH2K, Chlamydia virus Chp1, Chlamydia virus Chp2, Chlamydia virus CPAR39, Chlamydia virus CPG1, Spiroplasma virus SpV4, Acholeplasma virus L2, Pseudomonas virus PR4, Pseudomonas virus PRD1, Bacillus virus AP50, Bacillus virus Bam35, Bacillus virus GIL16, Bacillus virus Wip1, Escherichia virus phi80, Escherichia virus RB42, Escherichia virus T2, Escherichia virus T3, Escherichia virus T6, Escherichia virus VT2-Sa, Escherichia virus VT1-Sakai, Escherichia virus VT2-Sakai, Escherichia virus CP-933V, Escherichia virus P27, Escherichia virus Stx2phi-I, Escherichia virus Stx1phi, Escherichia virus Stx2phi-II, Escherichia virus CP-1639, based on the Escherichia virus BP-4795, Escherichia virus 86, Escherichia virus Min27, Escherichia virus 2851, Escherichia virus 1717, Escherichia virus YYZ-2008, Escherichia virus EC026_P06, Escherichia virus ECO103_P15, Escherichia virus ECO103_P12, Escherichia virus ECO111_P16, Escherichia virus ECO111_P11, Escherichia virus VT2phi_272, Escherichia virus TL-2011c, Escherichia virus P13374, Escherichia virus Sp5.

In one embodiment, the bacterial virus particles target E. coli and includes the capsid of a bacteriophage selected in the group consisting of BW73, B278, D6, D108, E, EI, E24, E41, F1-2, FI-4, FI-5, H18A, Ff18B, i, MM, Mu, 025, PhI-5, Pk, PSP3, PI, PID, P2, P4, SI, Wφ, φK13, φI, φ2, φ7, φ92, 7 A, 8φ, 9φ, 18, 28-1, 186, 299, HH-Escherichia (2), AB48, CM, C4, C16, DD-VI, E4, E7, E28, FII, FI3, H, HI, H3, H8, K3, M, N, ND-2, ND-3, ND4, ND-5, ND6, ND-7, Ox-I, Ox-2, Ox-3, Ox-4, Ox-5, Ox-6, PhI-I, RB42, RB43, RB49, RB69, S, Sal-I, Sal-2, Sal-3, Sal-4, Sal-5, Sal-6, TC23, TC45, TulI*-6, TulP-24, TulI*46, TulP-60, T2, T4, T6, T35, αI, 1, IA, 3, 3A, 3T+, 5φ, 9266Q, CFO103, HK620, J, K, KIF, m59, no. A, no. E, no. 3, no. 9, N4, sd, T3, T7, WPK, W31, ΔH, φC3888, φK3, φK7, φK12, φV-1, ϕ04-CF, ϕ05, ϕ06, ϕ07, φI, φI.2, φ20, φ95, φ263, φIO92, φI, φII, Ω8, 1, 3, 7, 8, 26, 27, 28-2, 29, 30, 31, 32, 38, 39, 42, 933W, NN-Escherichia (1), Esc-7-11, AC30, CVX-5, CI, DDUP, ECI, EC2, E21, E29, FI, F26S, F27S, Hi, HK022, HK97, HK139, HK253, HK256, K7, ND-I, PA-2, q, S2, TI), T3C, T5, UC-I, w, β4, γ2, λ, ϕD326, φγ, ϕ06, ϕ7, ϕ10, φ80, χ, 2, 4, 4A, 6, 8A, 102, 150, 168, 174, 3000, AC6, AC7, AC28, AC43, AC50, AC57, AC81, AC95, HK243, KIO, ZG/3A, 5, 5A, 21EL, H19-J and 933H.

In some embodiment the vectors disclosed herein may be used in combination with prebiotics. Prebiotics include, but are not limited to, amino acids, biotin, fructo-oligosaccharide, galacto-oligosaccharides, hemicelluloses (e.g., arabinoxylan, xylan, xyloglucan, and glucomannan), inulin, chitin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, gums (e.g., guar gum, gum arabic and carrageenan), oligofructose, oligodextrose, tagatose, resistant maltodextrins (e.g., resistant starch), trans-galactooligosaccharide, pectins (e.g., xylogalactouronan, citrus pectin, apple pectin, and rhamnogalacturonan-I), dietary fibers (e.g., soy fiber, sugarbeet fiber, pea fiber, corn bran, and oat fiber) and xylooligosaccharides.

In other embodiment, the vectors disclosed herein may be used in combination with probiotics. Probiotics include, but are not limited to lactobacilli, bifidobacteria, streptococci, enterococci, propionibacteria, saccaromycetes, lactobacilli, bifidobacteria, or proteobacteria.

Screening Methods

The invention encompasses methods for screening for genetic modifications in bacteria. In one embodiment, the method comprises administering a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria, to a subject, subsequently collecting a bacterial sample from the subject, quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample. The method can further comprise quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest.

In one embodiment, the proportion of endogenous modified vs non-modified bacteria is quantified. Preferred percentages of bacteria with the genetic modification are at least 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 97%, 98%, 99%, 99.9%, 99.99%, and 100%.

In one embodiment, the number of non-modified endogenous bacteria is quantified prior to administering a vector. The patient can also be pre-screened to determine the genetic signature of the strains the patient carries. This will allow selection of an appropriate capsid to deliver the therapeutic payload based on the genetic signature of the strains the patient carry.

In preferred embodiments, the vector is in a pharmaceutical and veterinary composition. Preferably the vector is a bacteriophage.

The vector can be administered to the subject by any administration technique known in the art, depending on the vector and the target bacteria's expected location in or on the subject.

The bacterial sample can be collected by any means known in the art, such as biopsy, blood draw, urine sample, stool sample, or oral/nasal swab, etc.

The level of bacteria containing or not containing a genetic modification in a base of a DNA of interest can be determined by any technique known to the skilled artisan, such as routine diagnostic procedures including ELISA, PCR, High Resolution Melting, and nucleic acid sequencing.

The invention encompasses methods for determining the efficiency of a vector at inducing genetic mutations in situ. In one embodiment, the method comprises administering a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria, to a subject, subsequently collecting a bacterial sample from the subject, quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample.

In preferred embodiments, the vector is in a pharmaceutical and veterinary composition. Preferably the vector is a bacteriophage.

The vector can be administered to the subject by any administration technique known in the art, depending on the vector and the target bacteria's expected location in or on the subject.

The bacterial sample can be collected by any means known in the art, such as biopsy, blood draw, urine sample, stool sample, or oral/nasal swab, etc.

The invention encompasses methods for determining the effect of a genetic mutation on bacterial growth. In one embodiment, the method comprises administering a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria, to a subject, subsequently collecting at least two sequential bacterial samples from the subject, quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest in said bacterial samples.

In preferred embodiments, the vector is in a pharmaceutical and veterinary composition. Preferably the vector is a bacteriophage.

The vector can be administered to the subject by any administration technique known in the art, depending on the vector and the target bacteria's expected location in or on the subject.

The bacterial samples can be collected by any means known in the art, such as biopsy, blood draw, urine sample, stool sample, or oral/nasal swab, etc. The samples can be collected at any sequential time points. Preferably, the time between these collections is at least 3, 6, 12, 24, 48, 72, 96 hrs or 7, 14, 30, 60, 120, or 365 days.

All of the screening methods of the invention can use any of the vectors and enzymes/systems of the invention to screen for any of the genetic modification of the invention.

All of the screening methods of the invention can further include a step of comparing the level of bacteria containing a genetic modification in a base of a DNA of interest with the level of bacteria not containing a genetic modification the base of a DNA of interest in a bacterial sample.

All of the screening methods of the invention can further include a step of contacting the vector with bacteria in liquid or solid culture and quantifying the level of bacteria containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample. The method can further comprise quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest.

In one embodiment, the method comprises providing a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria. The method can further comprise contacting the vector with bacteria in liquid or solid culture and quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample. The method can further comprise quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest. The levels of bacteria containing a genetic modification in a base of a DNA of interest can be compared with the level of bacteria not containing a genetic modification the base of a DNA of interest over time in the culture. Preferably, the time between these comparisons is at least 1, 2, 3, 4, 5, 6, 12, 24, 48, 72, or 96 hours.

Pharmaceutical and Veterinary Compositions and In Situ Administration Methods

The invention encompasses pharmaceutical and veterinary compositions comprising the vectors of the invention.

The invention encompasses in situ administration of the pharmaceutical or veterinary composition to the bacteria in a subject. Any method known to the skilled artisan can be used to contact the vector with the bacterial target in situ.

The pharmaceutical or veterinary composition according to the invention may further comprise a pharmaceutically acceptable vehicle. A solid pharmaceutically acceptable vehicle may include one or more substances which may also act as flavoring agents, lubricants, solubilisers, suspending agents, dyes, fillers, glidants, compression aids, inert binders, sweeteners, preservatives, dyes, coatings, or tablet-disintegrating agents. Suitable solid vehicles include, for example calcium phosphate, magnesium stearate, talc, sugars, lactose, dextrin, starch, gelatin, cellulose, polyvinylpyrrolidone, low melting waxes and ion exchange resins.

The pharmaceutical or veterinary composition may be prepared as a sterile solid composition that may be suspended at the time of administration using sterile water, saline, or other appropriate sterile injectable medium. The pharmaceutical or veterinary compositions of the invention may be administered orally in the form of a sterile solution or suspension containing other solutes or suspending agents (for example, enough saline or glucose to make the solution isotonic), bile salts, acacia, gelatin, sorbitan monoleate, polysorbate 80 (oleate esters of sorbitol and its anhydrides copolymerized with ethylene oxide) and the like. The particles according to the invention can also be administered orally either in liquid or solid composition form. Compositions suitable for oral administration include solid forms, such as pills, capsules, granules, tablets, and powders, and liquid forms, such as solutions, syrups, elixirs, and suspensions. Forms useful for enteral administration include sterile solutions, emulsions, and suspensions.

The bacterial virus particles according to the invention may be dissolved or suspended in a pharmaceutically acceptable liquid vehicle such as water, an organic solvent, a mixture of both or pharmaceutically acceptable oils or fats. The liquid vehicle can contain other suitable pharmaceutical additives such as solubilisers, emulsifiers, buffers, preservatives, sweeteners, flavouring agents, suspending agents, thickening agents, colours, viscosity regulators, stabilizers or osmo-regulators. Suitable examples of liquid vehicles for oral and enteral administration include water (partially containing additives as above, e.g. cellulose derivatives, preferably sodium carboxymethyl cellulose solution), alcohols (including monohydric alcohols and polyhydric alcohols, e.g. glycols) and their derivatives, and oils (e.g. fractionated coconut oil and arachis oil). For parenteral administration, the vehicle can also be an oily ester such as ethyl oleate and isopropyl myristate. Sterile liquid vehicles are useful in sterile liquid form compositions for enteral administration. The liquid vehicle for pressurized compositions can be a halogenated hydrocarbon or other pharmaceutically acceptable propellant.

In some embodiments, the invention encompasses pharmaceutical or veterinary composition formulated for delayed or gradual enteric release. In preferred embodiments, formulations or pharmaceutical preparations of the invention are formulated for delivery of the vector into the distal small bowel and/or the colon. The formulation can allow the vector to pass through stomach acid and pancreatic enzymes and bile, and reach undamaged to be viable in the distal small bowel and colon.

In some embodiments, the pharmaceutical or veterinary composition is micro-encapsulated, formed into tablets and/or placed into capsules, preferably enteric-coated capsules.

In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release, using cellulose acetate (CA) and polyethylene glycol (PEG). In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release using a hydroxypropylmethylcellulose (HPMC), a microcrystalline cellulose (MCC) and magnesium stearate. the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release using e.g., a poly(meth)acrylate, e.g. a methacrylic acid copolymer B, a methyl methacrylate and/or a methacrylic acid ester, or a polyvinylpyrrolidone (PVP).

In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release using a release-retarding matrix material such as: an acrylic polymer, a cellulose, a wax, a fatty acid, shellac, zein, hydrogenated vegetable oil, hydrogenated castor oil, polyvinylpyrrolidone, a vinyl acetate copolymer, a vinyl alcohol copolymer, polyethylene oxide, an acrylic acid and methacrylic acid copolymer, a methyl methacrylate copolymer, an ethoxyethyl methacrylate polymer, a cyanoethyl methacrylate polymer, an aminoalkyl methacrylate copolymer, a poly(acrylic acid), a poly(methacrylic acid), a methacrylic acid alkylamide copolymer, a poly(methyl methacrylate), a poly(methacrylic acid anhydride), a methyl methacrylate polymer, a polymethacrylate, a poly(methyl methacrylate) copolymer, a polyacrylamide, an aminoalkyl methacrylate copolymer, a glycidyl methacrylate copolymer, a methyl cellulose, an ethylcellulose, a carboxymethylcellulose, a hydroxypropylmethylcellulose, a hydroxymethyl cellulose, a hydroxyethyl cellulose, a hydroxypropyl cellulose, a crosslinked sodium carboxymethylcellulose, a crosslinked hydroxypropylcellulose, a natural wax, a synthetic wax, a fatty alcohol, a fatty acid, a fatty acid ester, a fatty acid glyceride, a hydrogenated fat, a hydrocarbon wax, stearic acid, stearyl alcohol, beeswax, glycowax, castor wax, carnauba wax, a polylactic acid, polyglycolic acid, a co-polymer of lactic and glycolic acid, carboxymethyl starch, potassium methacrylate/divinylbenzene copolymer, crosslinked polyvinylpyrrolidone, polyvinylalcohols, polyvinylalcohol copolymers, polyethylene glycols, non-crosslinked polyvinylpyrrolidone, polyvinyl acetates, polyvinylacetate copolymers or any combination thereof.

In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release as described in U.S. Pat. App. Pub. 20110218216, which describes an extended release pharmaceutical composition for oral administration, and uses a hydrophilic polymer, a hydrophobic material and a hydrophobic polymer or a mixture thereof, with a microenvironment pH modifier. The hydrophobic polymer can be ethylcellulose, cellulose acetate, cellulose propionate, cellulose butyrate, methacrylic acid-acrylic acid copolymers or a mixture thereof. The hydrophilic polymer can be polyvinylpyrrolidone, hydroxypropylcellulose, methylcellulose, hydroxypropylmethyl cellulose, polyethylene oxide, acrylic acid copolymers or a mixture thereof. The hydrophobic material can be a hydrogenated vegetable oil, hydrogenated castor oil, carnauba wax, candellia wax, beeswax, paraffin wax, stearic acid, glyceryl behenate, cetyl alcohol, cetostearyl alcohol or and a mixture thereof. The microenvironment pH modifier can be an inorganic acid, an amino acid, an organic acid or a mixture thereof. Alternatively, the microenvironment pH modifier can be lauric acid, myristic acid, acetic acid, benzoic acid, palmitic acid, stearic acid, oxalic acid, malonic acid, succinic acid, adipic acid, sebacic acid, fumaric acid, maleic acid; glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, sodium dihydrogen citrate, gluconic acid, a salicylic acid, tosylic acid, mesylic acid or malic acid or a mixture thereof.

In some embodiments, the pharmaceutical or veterinary compositions are a powder that can be included into a tablet or a suppository. In alternative embodiments, a formulation or pharmaceutical preparation of the invention can be a ‘powder for reconstitution’ as a liquid to be drunk or otherwise administered.

In some embodiments, the pharmaceutical or veterinary compositions can be administered in a cream, gel, lotion, liquid, feed, or aerosol spray. In some embodiments, a bacteriophage is immobilized to a solid surface using any substance known in the art and any technology known in the art, for example, but not limited to immobilization of bacteriophages onto polymeric beads using technology as outlined in U.S. Pat. No. 7,482,115, which is incorporated herein by reference. Phages may be immobilized onto appropriately sized polymeric beads so that the coated beads may be added to aerosols, creams, gels or liquids. The size of the polymeric beads may be from about 0.1 μm to 500 μm, for example 50 pm to 100 μm. The coated polymeric beads may be incorporated into animal feed, including pelleted feed and feed in any other format, incorporated into any other edible device used to present phage to the animals, added to water offered to animals in a bowl, presented to animals through water feeding systems. In some embodiments, the compositions are used for treatment of surface wounds and other surface infections using creams, gels, aerosol sprays and the like.

In some embodiments, the pharmaceutical or veterinary compositions can be administered by inhalation, in the form of a suppository or pessary, topically (e.g., in the form of a lotion, solution, cream, ointment or dusting powder), epi- or transdermally (e.g., by use of a skin patch), orally (e.g., as a tablet, which may contain excipients such as starch or lactose), as a capsule, ovule, elixirs, solutions, or suspensions (each optionally containing flavoring, coloring agents and/or excipients), or they can be injected parenterally (e.g., intravenously, intramuscularly or subcutaneously). For parenteral administration, the compositions may be used in the form of a sterile aqueous solution which may contain other substances, for example enough salts or monosaccharides to make the solution isotonic with blood. For buccal or sublingual administration the compositions may be administered in the form of tablets or lozenges which can be formulated in a conventional manner. In a preferred embodiment, a bacteriophage and/or polypeptide of the present invention is administered topically, either as a single agent, or in combination with other antibiotic treatments, as described herein or known in the art.

In some embodiments, the pharmaceutical or veterinary compositions can also be dermally or transdermally administered. For topical application to the skin, the pharmaceutical or veterinary composition can be combined with one or a combination of carriers, which can include but are not limited to, an aqueous liquid, an alcohol base liquid, a water soluble gel, a lotion, an ointment, a nonaqueous liquid base, a mineral oil base, a blend of mineral oil and petrolatum, lanolin, liposomes, proteins carriers such as serum albumin or gelatin, powdered cellulose carmel, and combinations thereof. A topical mode of delivery may include a smear, a spray, a bandage, a time-release patch, a liquid-absorbed wipe, and combinations thereof. The pharmaceutical or veterinary composition can be applied to a patch, wipe, bandage, etc., either directly or in a carrier(s). The patches, wipes, bandages, etc., may be damp or dry, wherein the phage and/or polypeptide (e.g., a lysin) is in a lyophilized form on the patch. The carriers of topical compositions may comprise semi-solid and gel-like vehicles that include a polymer thickener, water, preservatives, active surfactants, or emulsifiers, antioxidants, sun screens, and a solvent or mixed solvent system. U.S. Pat. No. 5,863,560 discloses a number of different carrier combinations that can aid in the exposure of skin to a medicament, and its contents are incorporated herein.

For intranasal or administration by inhalation, the pharmaceutical or veterinary composition is conveniently delivered in the form of a dry powder inhaler or an aerosol spray presentation from a pressurized container, pump, spray, or nebuliser with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, a hydrofluoroalkane such as 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane, carbon dioxide, or other suitable gas. In the case of a pressurized aerosol, the dosage unit may be determined by providing a valve to deliver a metered amount. The pressurized container, pump, spray, or nebuliser may contain a solution or suspension of the active compound, e.g., using a mixture of ethanol and the propellant as the solvent, which may additionally contain a lubricant, e.g., sorbitan trioleate. Capsules and cartridges (made, for example, from gelatin) for use in an inhaler or insufflator may be formulated to contain a powder mix of the bacteriophage and/or polypeptide of the invention and a suitable powder base such as lactose or starch.

For administration in the form of a suppository or pessary, the pharmaceutical or veterinary composition can be applied topically in the form of a gel, hydrogel, lotion, solution, cream, ointment, or dusting powder. Compositions of the invention may also be administered by the ocular route. For ophthalmic use, the compositions of the invention can be formulated as micronized suspensions in isotonic, pH adjusted, sterile saline, or, preferably, as solutions in isotonic, pH adjusted, sterile saline, optionally in combination with a preservative such as a benzylalkonium chloride. Alternatively, they may be formulated in an ointment such as petrolatum.

Dosages and desired drug concentrations of the pharmaceutical and veterinary composition compositions of the present invention may vary depending on the particular use. The determination of the appropriate dosage or route of administration is within the skill of an ordinary physician. Animal experiments can provide reliable guidance for the determination of effective doses in human therapy.

For transdermal administration, the pharmaceutical or veterinary composition can be formulated into ointment, cream or gel form and appropriate penetrants or detergents could be used to facilitate permeation, such as dimethyl sulfoxide, dimethylacetamide and dimethylformamide.

For transmucosal administration, nasal sprays, rectal or vaginal suppositories can be used. The active compounds can be incorporated into any of the known suppository bases by methods known in the art. Examples of such bases include cocoa butter, polyethylene glycols (carbowaxes), polyethylene sorbitan monostearate, and mixtures of these with other compatible materials to modify the melting point or dissolution rate.

Disease Treatment

The invention encompasses the treatment of diseases and metabolic disorders caused by bacteria. The diseases or disorders caused by bacteria may be selected from the group consisting of skin chronic inflammation such as acne (acne vulgaris), progressive macular hypomelanosis, abdominal cramps, acute epiglottitis, arthritis, bacteraemia, bloody diarrhea, botulism, Brucellosis, brain abscess, cardiomyopathy, chancroid venereal disease, Chlamydia, Crohn's disease, conjunctivitis, cholecystitis, colorectal cancer, polyposis, dysbiosis, Lyme disease, diarrhea, diphtheria, duodenal ulcers, endocarditis, erysipelothricosis, enteric fever, fever, glomerulonephritis, gastroenteritis, gastric ulcers, Guillain-Barre syndrome tetanus, gonorrhoea, gingivitis, inflammatory bowel diseases, irritable bowel syndrome, leptospirosis, leprosy, listeriosis, tuberculosis, Lady Widermere syndrome, Legionaire's disease, meningitis, mucopurulent conjunctivitis, multi-drug resistant bacterial infections, multi-drug resistant bacterial carriage, myocarditis, myonecrosis-gas gangrene, Mycobacterium avium complex, neonatal necrotizing enterocolitis, nocardiosis, nosocomial infection, otitis, periodontitis, phalyngitis, pneumonia, peritonitis, purpuric fever, Rocky Mountain spotted fever, shigellosis, syphilis, sinusitis, sigmoiditis, septicaemia, subcutaneous abscesses, tularaemia, tracheobronchitis, tonsillitis, typhoid fever, ulcerative colitis, urinary infection, whooping cough, Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic steatohepatitis (NASH).

The infection caused by bacteria may be selected from the group consisting of infections, preferably intestinal infections such as esophagitis, gastritis, enteritis, colitis, sigmoiditis, rectitis, and peritonitis, urinary tract infections, vaginal infections, female upper genital tract infections such as salpingitis, endometritis, oophoritis, myometritis, parametritis and infection in the pelvic peritoneum, respiratory tract infections such as pneumonia, intra-amniotic infections, odontogenic infections, endodontic infections, fibrosis, meningitis, bloodstream infections, nosocomial infection such as catheter-related infections, hospital acquired pneumonia, post-partum infection, hospital acquired gastroenteritis, hospital acquired urinary tract infections, or a combination thereof. Preferably, the infection according to the invention is caused by a bacterium presenting an antibiotic resistance. In a particular embodiment, the infection is caused by a bacterium as listed above in the targeted bacteria.

The disclosure also concerns a pharmaceutical or veterinary composition of the invention for the treatment of a metabolic disorder including, for example, obesity, type 2 diabetes and nonalcoholic fatty liver disease. Indeed, emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites (Tilg et al., Nature Reviews Immunology, volume 20, pages 40-54, 2020). The pharmaceutical or veterinary composition may thus be used to deliver in some intestinal bacteria a nucleic acid of interest which can alter the intestinal microbiota composition or its metabolites (e.g. by inducing expression, overexpression or secretion of some molecules by said bacteria, for example molecules having a beneficial role on metabolic inflammation). The disclosure also concerns the use of a pharmaceutical or veterinary composition of the invention for the manufacture of a medicament for the treatment of a metabolic disorder including, for example, obesity, type 2 diabetes and nonalcoholic fatty liver disease. It also relates to a method for treating a metabolic disorder including, for example, obesity, type 2 diabetes and nonalcoholic fatty liver disease, comprising administering to a subject having a metabolic disorder in need of treatment the provided pharmaceutical or veterinary composition, in particular a therapeutically effective amount of the provided pharmaceutical or veterinary composition.

In a particular embodiment, the invention concerns a pharmaceutical or veterinary composition for use in the treatment of pathologies involving bacteria of the human microbiome, such as inflammatory and auto-immune diseases, cancers, infections or brain disorders. Indeed, some bacteria of the microbiome, without triggering any infection, can secrete molecules that will induce and/or enhance inflammatory or auto-immune diseases or cancer development. More specifically, the present invention relates also to modulating microbiome composition to improve the efficacy of immunotherapies based, for example, on CAR-T (Chimeric Antigen Receptor T) cells, TIL (Tumor Infiltrating Lymphocytes) and Tregs (Regulatory T cells) also known as suppressor T cells. Modulation of the microbiome composition to improve the efficacy of immunotherapies may also include the use of immune checkpoint inhibitors well known in the art such as, without limitation, PD-1 (programmed cell death protein 1) inhibitor, PD-L1 (programmed death ligand 1) inhibitor and CTLA-4 (cytotoxic T lymphocyte associated protein 4).

Some bacteria of the microbiome can also secrete molecules that will affect the brain.

Therefore, a further object of the invention is a method, in particular a non-therapeutic method, for controlling the microbiome of a subject, comprising administering an effective amount of the pharmaceutical composition as disclosed herein in said subject. A further object of the invention is the pharmaceutical composition of the invention further use for controlling the microbiome of a subject.

In a particular embodiment, the invention also relates to a method for personalized treatment for an individual in need of treatment for a bacterial infection comprising: i) obtaining a biological sample from the individual and determining a group of bacterial DNA sequences from the sample; ii) based on the determining of the sequences, identifying one or more pathogenic bacterial strains or species that were in the sample; and iii) administering to the individual a pharmaceutical composition according to the invention capable of recognizing each pathogenic bacterial strain or species identified in the sample and to deliver the packaged payload. The present invention also concerns a pharmaceutical composition of the invention for use in a method for personalized treatment for an individual in need of treatment for a bacterial infection, said method comprising: i) obtaining a biological sample from the individual and determining a group of bacterial DNA sequences from the sample; ii) based on the determining of the sequences, identifying one or more pathogenic bacterial strains or species that were in the sample; and wherein the pharmaceutical composition is capable of recognizing each pathogenic bacterial strain or species identified in the sample and to deliver the packaged plasmid.

Preferably, the biological sample comprises pathological and non-pathological bacterial species, and subsequent to administering the pharmaceutical or veterinary composition according to the invention to the individual, the amount of pathogenic bacteria on or in the individual are reduced, but the amount of non-pathogenic bacteria is not reduced.

In another particular embodiment, the invention concerns a pharmaceutical or veterinary composition according to the invention for use in order to improve the effectiveness of drugs. Indeed, some bacteria of the microbiome, without being pathogenic by themselves, are known to be able to metabolize drugs and to modify them in ineffective or harmful molecules.

In another particular embodiment, the invention concerns the in-situ bacterial production of any compound of interest, including therapeutic compound such as prophylactic and therapeutic vaccine for mammals. The compound of interest can be produced inside the targeted bacteria, secreted from the targeted bacteria or expressed on the surface of the targeted bacteria. In a more particular embodiment, an antigen is expressed on the surface of the targeted bacteria for prophylactic and/or therapeutic vaccination.

Method for Counter-Selection In Situ

In a particular embodiment, the vector encodes a DNA modifying enzyme, in particular a programmed nuclease, that can discriminate between targeted bacteria that have been genetically modified in situ and targeted bacteria in which the modification has not occurred, leading to the specific killing of the targeted bacteria in which the modification has not occurred.

In a particular embodiment, the nuclease can be a RNA-guided nuclease.

In a particular embodiment, the design of the vector increases the chances that the killing effect mediated by said programmed nuclease is delayed, thereby providing enough time for the target DNA sequence to be edited by the base-editing or prime-editing enzyme/system.

The invention also provides compositions and methods to ensure a robust alteration of all targeted bacteria within a microbiome population, thanks to the delivery of a nuclease programmed to discriminate between targeted bacteria that have been genetically modified in situ and targeted bacteria in which the modification has not occurred, leading to the specific killing of those in which the modification has not occurred. In a particular embodiment, the vector of the invention is thus used in combination with a nucleic acid encoding a nuclease programmed to discriminate between targeted bacteria that have been genetically modified in situ and targeted bacteria in which the modification has not occurred, leading to the specific killing of those in which the modification has not occurred. In a particular embodiment, the delivery of such a programmed nuclease is either on the same vector as the one carrying the base-editing nuclease, or on a different vector. In a particular embodiment, the delivery of such programmed nuclease is implemented either simultaneously or after the vector encoding the base-editing nuclease. If delivered simultaneously, the vector can be engineered to have a delayed targeting process for the programmed nuclease leading to a double strand break.

Non-Therapeutic Uses

The present invention also relates to a non-therapeutic use of the bacterial delivery particles of the invention. For instance, the non-therapeutic use can be a cosmetic use or a use for improving the well-being of a subject, in particular a subject who does not suffer from a disease. Accordingly, the present invention also relates to a cosmetic composition or a non-therapeutic composition comprising the bacterial delivery particles of the invention.

Subject, Regimen and Administration

The subject according to the invention is an animal, preferably a mammal, even more preferably a human. However, the term “subject” can also refer to non-human animals, in particular mammals such as dogs, cats, horses, cows, pigs, sheep, donkeys, rabbits, ferrets, gerbils, hamsters, chinchillas, rats, mice, guinea pigs and non-human primates, among others, or non-mammals such as poultry, that are in need of treatment.

The human subject according to the invention may be a human at the prenatal stage, a new-born, a child, an infant, an adolescent or an adult at any age.

In a preferred embodiment, the subject has been diagnosed with, or is at risk of developing an infection, a disorder and/or a disease preferably due to a bacterium. Diagnostic methods of such infection, disorder and/or disease are well known by the man skilled in the art.

In a particular embodiment, the infection, disorder and/or disease presents a resistance to treatment, preferably the infection, disorder or disease presents an antibiotic resistance.

In a particular embodiment, the subject has never received any treatment prior to the administration of the delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention.

In a particular embodiment, the subject has already received at least one line of treatment, preferably several lines of treatment, prior to the administration of the delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention.

Preferably, the treatment is administered regularly, preferably between every day and every month, more preferably between every day and every two weeks, more preferably between every day and every week, even more preferably the treatment is administered every day. In a particular embodiment, the treatment is administered several times a day, preferably 2 or 3 times a day, even more preferably 3 times a day.

The duration of treatment with delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or with a pharmaceutical or veterinary composition according to the invention, is preferably comprised between 1 day and 20 weeks, more preferably between 1 day and 10 weeks, still more preferably between 1 day and 4 weeks, even more preferably between 1 day and 2 weeks. In a particular embodiment, the duration of the treatment is about 1 week. Alternatively, the treatment may last as long as the infection, disorder and/or disease persists.

The form of the pharmaceutical or veterinary compositions, the route of administration and the dose of administration of delivery vehicles according to the invention, preferably of a vector according to the invention, particularly of a payload packaged into a delivery vehicle according to the invention, preferably of a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention can be adjusted by the man skilled in the art according to the type and severity of the infection (e.g. depending on the bacteria species involved in the disease, disorder and/or infection and its localization in the patient's or subject's body), and to the patient or subject, in particular its age, weight, sex, and general physical condition.

Particularly, the amount of delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention, to be administered has to be determined by standard procedure well known by those of ordinary skills in the art. Physiological data of the patient or subject (e.g. age, size, and weight) and the routes of administration have to be taken into account to determine the appropriate dosage, so as a therapeutically effective amount will be administered to the patient or subject.

For example, the total amount of delivery vehicles, particularly a payload packaged into a delivery vehicle according to the invention, preferably a plasmid or phagemid packaged into a bacterial virus particle according to the invention, for each administration is comprised between 10¹⁴and 10¹⁵delivery vehicles.

The present invention further concerns the following embodiments:

1. A method of modifying a naturally occurring bacteria in situ comprising:

genetically modifying a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence, wherein said genetic modification does not lead to the death of bacteria.

2. The method according to embodiment 1, comprising contacting said naturally occurring bacteria with a vector.

3. The method according to embodiment 1, comprising contacting said naturally occurring bacteria with a vector located inside a delivery vehicle.

4. The method according to embodiment 3, wherein said vector located inside a delivery vehicle is a phagemid.

5. The method according to embodiment 1, comprising transducing said naturally occurring bacteria with a packaged phagemid.

6. The method according to embodiment 4 or 5, wherein said phagemid comprises a nucleic acid sequence encoding a dCas9 (dead-Cas9) or nCas9 (nickase Cas9).

7. The method according to embodiment 4 or 5, wherein said phagemid comprises a nucleic acid sequence encoding a dCas9 and a deaminase domain, or a nCas9 and deaminase domain.

8. The method according to embodiment 4 or 5, wherein said phagemid comprises a nucleic acid sequence encoding a dCas9 and a reverse transcriptase domain, or a nCas9 and a reverse transcriptase domain.

9. The method according to any of embodiments 2 to 8, wherein the vector or phagemid further comprises a conditional origin of replication which is inactive in the targeted naturally occurring bacteria but is active in a donor bacterial cell.

10. The method according to embodiment 9, wherein said conditional origin of replication is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof.

11. The method according to embodiment 10, wherein said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, nucleic acid, RNA, molecule or any combination thereof.

12. The method according to any of embodiments 9-11, wherein said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs).

13. The method according to embodiment 12, wherein said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase.

14. The method according to embodiment 12 or 13, wherein said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073.

15. The method according to embodiment 14, wherein said conditional origin of replication comprises or consists of the sequence SEQ ID NO: 7 or SEQ ID NO: 8.

16. The method according to any of embodiments 1-15, wherein said genetic modification is a point mutation.

17. The method according to any of embodiments 1-16, wherein said genetic modification is a point mutation leading to gene disruption.

18. The method according to any of embodiments 1-17, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

19. The method according to any of embodiments 1-18, wherein the genetic modification is in a bacterial toxin gene.

20. The method according to embodiment 19, comprising a genetic modification of the ClbP gene in pks+ E. coli that results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity.

21. The method according to embodiment 20, comprising a genetic modification at S95 or K98 of the ClbP gene.

22. The method according to embodiment 21, comprising a genetic modification of S95A, S95R or K98T.

23. The method according to any of embodiments 1-18, wherein the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene.

24. The method according to embodiment 16, wherein the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein with the genetic modification shows lower homology with human MYH6 cardiac peptide as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification.

25. The method according to any of embodiments 1-18, wherein the genetic modification is in Propionibacterium propionicum Ro60 orthologs.

26. The method according to embodiment 25, wherein the genetic modification is in at least one Propionibacterium propionicum Ro60 ortholog epitope leading to weaker or no recognition by the human immune system.

27. The method according to any of embodiments 1-26, comprising genetically modifying at least one gene in the naturally occurring bacteria in situ in a human.

28. A method of modulating host-microbiome interaction by genetically modifying naturally occurring bacteria in situ wherein said naturally occurring bacteria is involved in microbiome associated disorder or disease comprising:

genetically modifying a DNA sequence responsible for the microbiome associated disorder or disease in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence,

wherein said genetic modification reduces the effects of the microbiome associated disorder or disease, and

wherein said genetic modification does not lead to the death of bacteria.

29. The method according to embodiment 28, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

30. A method to prevent or intervene in the course of an auto-immune disease/reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the host microbiome, comprising:

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the gene coding for the immunogenic component results in loss of its immunogenic component;

wherein genetic modification does not lead to the direct death of the bacteria.

31. The method according to embodiment 30, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

32. The method according to embodiment 30 comprising contacting said bacteria with a phagemid encoding an enzyme that modifies the genome of said bacteria.

33. The method according to embodiment 30, comprising contacting said bacteria with a phagemid encoding an enzyme that is a base-editor.

34. The method according to embodiment 30, comprising contacting said bacteria with a phagemid encoding an enzyme that is a prime-editor.

35. The method according to any of embodiments 28 or 30, wherein the genetic modification is a point mutation that results in a change of amino-acid in a mimic peptide and renders the mimic peptide not immunogenic and/or not recognized by the immune system.

36. The method according to embodiment 28, wherein the genetic modification results in a change of sugar profile on the bacterial membrane.

37. The method according to embodiment 28, wherein the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of sugar profile on the bacterial membrane.

38. The method according to embodiment 28, wherein the genetic modification results in a change of lipid profile on the bacterial membrane.

39. The method according to embodiment 28, wherein the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of lipid profile on the bacterial membrane.

40. The method according to any of embodiments 1-30, wherein the genetic modification renders a catalytic site inactive.

41. The method according to any of embodiments 1-30, wherein the genetic modification renders a binding site with a human cell receptor non-functional.

42. The method according to any of embodiments 1-30, wherein the genetic modification renders the bacteria more sensitive to detection by human immune cells.

43. A method for screening for genetic modifications in bacteria comprising:

administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene of a naturally occurring bacteria without introducing a double strand break in the DNA sequence,

subsequently collecting a bacterial sample from the subject, and

quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample.

44. The method according to embodiment 43, further comprising quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest.

45. A method for determining the efficiency of a vector at inducing genetic mutations in situ comprising:

subsequently collecting a bacterial sample from the subject,

quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest, and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample.

46. A method for determining the effect of a genetic mutation on bacterial growth comprising:

administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene of a naturally occurring bacteria, without introducing a double strand break in the DNA sequence,

subsequently collecting at least two sequential bacterial samples from the subject,

quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial samples.

47. The method according to any of embodiments 43 to 46, comprising a genetic modification of the ClbP gene in pks+ E. coli that results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity.

48. An engineered bacteriophage for modifying a naturally occurring bacteria in situ comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the genome of said target bacteria without introducing a double strand break in the DNA sequence, but does not lead to the death of the target bacteria.

49. The bacteriophage according to embodiment 48 for use for treating a disease or disorder, wherein the gene editing enzyme/system targets a gene within the target bacteria encoding a protein which is directly or indirectly responsible for said disease or disorder.

50. A method to modify the metabolism of a given drug in a host treated with said drug, by modifying at least one drug-targeting enzyme expressed by a bacterial population of the host microbiome, comprising:

wherein the genetic modification of the DNA sequence coding for the drug-targeting enzyme results in a modification of the drug metabolism in the host;

wherein genetic modification does not lead to the direct death of the bacteria.

Definitions

«vector»

As used herein, the term “vector” refers to any construct of sequences that are capable of expression of a polypeptide in a given host cell. If a vector is used then the choice of vector is dependent upon the method that will be used to transform host bacteria as is well known to those skilled in the art. Vectors can include, without limitation, plasmid vectors and recombinant phage vectors, or any other vector known in that art suitable for delivering a polypeptide of the invention to target bacteria. The skilled artisan is well aware of the genetic elements that must be present on the vector in order to successfully transform, select and propagate host cells comprising any of the isolated nucleotides or nucleic acid sequences of the invention.

«delivery vehicle»

As used herein, the term «delivery vehicle» refers to any vehicle that allows the transfer of a payload or vector into a bacterium.

There are several types of delivery vehicle encompassed by the present invention including, without limitation, bacteriophage scaffold, virus scaffold, bacterial virus particle, chemical based delivery vehicle (e.g., cyclodextrin, calcium phosphate, cationic polymers, cationic liposomes), protein-based or peptide-based delivery vehicle, lipid-based delivery vehicle, nanoparticle-based delivery vehicles, non-chemical-based delivery vehicles (e.g., transformation, electroporation, sonoporation, optical transfection), particle-based delivery vehicles (e.g., gene gun, magnetofection, impalefection, particle bombardment, cell-penetrating peptides) or donor bacteria (conjugation).

Any combination of delivery vehicles is also encompassed by the present invention.

The delivery vehicle can refer to a bacteriophage derived scaffold and can be obtained from a natural, evolved or engineered capsid.

In some embodiment, the delivery vehicle is the payload or vector as bacteria are naturally competent to take up a payload or vector from the environment on their own.

«payload

As used herein, the term «payload» refers to any nucleic acid sequence or amino acid sequence, or a combination of both (such as, without limitation, peptide nucleic acid or peptide-oligonucleotide conjugate) transferred into a bacterium with a delivery vehicle.

The term «payload» may also refer to a plasmid, a vector or a cargo.

The payload can be a phagemid or phasmid obtained from natural, evolved or engineered bacteriophage genome. The payload can also be composed only in part of phagemid or phasmid obtained from natural, evolved or engineered bacteriophage genome.

In some embodiment, the payload is the delivery vehicle as bacteria are naturally competent to take up a payload from the environment on their own.

«nucleic acid»

As used herein, the term “nucleic acid” refers to a sequence of at least two nucleotides covalently linked together which can be single-stranded or double-stranded or contains portion of both single-stranded and double-stranded sequence. Nucleic acids of the present invention can be naturally occurring, recombinant or synthetic. The nucleic acid can be in the form of a circular sequence or a linear sequence or a combination of both forms. The nucleic acid can be DNA, both genomic or cDNA, or RNA or a combination of both. The nucleic acid may contain any combination of deoxyribonucleotides and ribonucleotides, and any combination of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine, hypoxanthine, isocytosine, 5-hydroxymethylcytosine and isoguanine. Other examples of modified bases that can be used in the present invention are detailed in Chemical Reviews 2016, 116 (20) 12655-12687. The term “nucleic acid” also encompasses any nucleic acid analogs which may contain other backbones comprising, without limitation, phosphoramide, phosphorothioate, phosphorodithioate, O-methylphosphoroamidite linkage and/or deoxyribonucleotides and ribonucleotides nucleic acids. Any combination of the above features of a nucleic acid is also encompassed by the present invention.

“Phagemid” and “packaged phagemid”

As used herein, the term “phagemid” or “phasmid” are equivalent and refer to a recombinant DNA vector comprising at least one sequence of a bacteriophage genome and which is preferably not able of producing progeny, more particularly a vector that derives from both a plasmid and a bacteriophage genome. A phagemid of the disclosure comprises a phage packaging site and optionally an origin of replication (ori), in particular a bacterial and/or phage origin of replication. In one embodiment, the phagemid does not comprise a origin of replication and thus cannot replicate by itself once injected into a bacterium. Alternatively, the phagemid comprises a plasmid origin of replication, in particular a bacterial and/or phage origin of replication.

As used herein, the term “packaged phagemid” refers to a phagemid which is encapsidated in a bacteriophage scaffold, bacterial virus particle or capsid. Particularly, it refers to a bacteriophage scaffold, bacterial virus particle or capsid devoid of a wild-type bacteriophage genome. The packaged phagemid may be produced with a helper phage strategy, well known from the man skilled in the art. The helper phage comprises all the genes coding for the structural and functional proteins that are indispensable for the phagemid according to the invention to be encapsidated. The packaged phagemid may be produced with a satellite virus strategy, also known from the man skilled in the art. Satellite virus are subviral agent and are composed of nucleic acid that depends on the co-infection of a host cell with a helper virus for all the morphogenetic functions, whereas for all its episomal functions (integration and immunity, multicopy plasmid replication) the satellite is completely autonomous from the helper. In one embodiment, the satellite genes can encode proteins that promote capsid size reduction of the helper phage, as described for the P4 Sid protein that controls the P2 capsid size to fit its smaller genome.

«peptide»

As used herein, the term “peptide” refers both to a short chain of at least 2 amino acids linked between each other and to a part of, a subset of, or a fragment of a protein which part, subset or fragment being not expressed independently from the rest of the protein. In some instances, a peptide is a protein. In some other instances, a peptide is not a protein and peptide only refers to a part, a subset or a fragment of a protein. Preferably, the peptide is from 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 amino acids to 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 40, 50, 100, 200 amino acids in size.

“homology” and “identity”

By “homology” is meant herein the amino acid sequence of two or more amino acid molecules is partially or completely identical. In certain embodiments the homologous amino acid sequence has 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95% sequence similarity or identity to the amino acid sequence of reference.

As used herein, the percent homology between two sequences is equivalent to the percent identity between the two sequences. The percent identity is calculated in relation to polymers (e.g., polynucleotide or polypeptide) whose sequences have been aligned. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % homology=# of identical positions/total # of positions x 100), taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences. The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm, as described in the non-limiting examples below.

The percent identity between two amino acid sequences can be determined using the algorithm of E. Meyers and W. Miller (Comput. Appl. Biosci., 4: 11-17 (1988)) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. In addition, the percent identity between two amino acid sequences can be determined using the Needleman and Wunsch (J. Mol. Biol. 48:444-453 (1970)) algorithm which has been incorporated into the GAP program in the GCG software package (available at www.gcg.com), using a BLOSUM62 matrix, a BLOSUM30 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. In a specific embodiment the BLOSUM30 matrix is used with gap open penalty of 12 and gap extension penalty of 4.

Brief description of the sequences

SEQ

ID NO:
Description
Type

1
Payload encoding Adenine base editor (ABE8e) and
DNA

guideRNA targeting mCherry

2
Payload encoding Adenine base editor (ABE8e) and
DNA

guideRNA targeting ß-lactamase

3
Payload encoding Cytosine base editor
DNA

(evoAPOBEC1-nCas9-UGI) and guideRNA

targeting mCherry

4
Payload encoding Cytosine base editor
DNA

(evoAPOBEC1-nCas9-UGI) and guideRNA targeting

ß-lactamase

5
mCherry gene
DNA

6
β-lactamase gene
DNA

7
Primase ori deltaGAAABCC
DNA

8
Primase ori devoid of restriction sites
DNA

9
insulin B9-25 epitope
Protein

10
T cell (β2GPI) epitope
Protein

11
B cell epitope
Protein

12
primase ori from the PICI of the Escherichia coli
DNA

strain CFT073

13
Restriction site
DNA

14
PICI primase-helicase
Protein

15
PICI primase-helicase
DNA

16
Ro60 B cell epitope
Protein

17
Ro60 T cell epitope (aa 316-335)
Protein

18
Ro60 T cell epitope (aa 369-383)
Protein

19-2313
Candidate mimic peptides
Protein

2314
RFP gene
DNA

2315
Payload encoding prime editor (PE) and pegRNA

targeting DNARFP

2316
ClbP
Protein

2317
ClbP gene
DNA

2318
FimH
Protein

2319
FimH gene
DNA

2320
Blc
Protein

2321
Blc gene
DNA

2322
beta-galactosidase
Protein

2323
beta-galactosidase gene
DNA

2324
MYH6_614-629
Protein

2325
Payload encoding prime editor (PE) and pegRNA
DNA

targeting RFP and containing an inducible promoter

EXAMPLES
Example 1—Method to Prevent Colorectal Cancer

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacteria results in single-amino acid mutations of the ClbP gene in pks+ E. coli and the inactivation of the genotoxic activity of the Colibactin toxin, but maintains the antagonistic activity of the toxin. The single-amino acid mutations of the ClbP gene in pks+ E. coli are a genetic modification selected from the group consisting of S95A, S95R and K98T¹. The bacteriophage vector is produced in E. coli to high titers and a pharmaceutical composition is prepared. The pharmaceutical composition is administered to human patients to generate in-situ genetic modification of the pks+ E. coli of the patient. The administration results in a population of E. coli in the patient in which the genotoxic activity of the Colibactin toxin has been inactivated, but the antagonistic activity of the toxin is maintained. Additional administrations over time further result in a diminution of the percentage of E. coli in the patient having a Colibactin toxin with genotoxic activity, while increasing the percentage of E. coli in the patient having a Colibactin toxin without genotoxic activity. In this way, the exposure of the patient to the negative effects of the genotoxic activity of the Colibactin toxin can be minimized.

Example 2—Method to Stop the Progression of Myocarditis

A method to stop the progression of myocarditis towards lethal cardiomyopathy by in situ genetic modification of the peptidic sequence of Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase that shows high homology with human MYH6 cardiac peptide is developed².

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacteria results in single-amino acid mutations in the peptidic sequence of Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase that decreases its homology with human MYH6 cardiac peptide, but maintains the activity of the enzyme. Multiple single-amino acid mutations are analyzed, starting with conservative mutations. The bacteriophage vector is produced in E. coli. to high titers and a pharmaceutical composition is prepared. The pharmaceutical composition is administered to human patients to generate in-situ genetic modification of the Bacteroides of the patient. The administration results in a population of Bacteroides in the patient in which the peptidic sequence of Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase has decreased homology with human MYH6 cardiac peptide. Additional administrations over time further result in a diminution of the percentage of Bacteroides in the patient having a peptidic sequence of Bacteroides beta-galactosidase with high homology with human MYH6 cardiac peptide, while increasing the percentage of Bacteroides in the patient having a peptidic sequence of Bacteroides beta-galactosidase with low homology with human MYH6 cardiac peptide. In this way, the exposure of the patient to the negative auto-immune effects caused by the immune cross-reactivity of the Bacteroides protein and the human MYH6 cardiac peptide can be minimized.

Example 3—Screening of Vectors

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacterial population results in single-amino acid mutations of the ClbP gene in pks+ E. coli and the inactivation of the genotoxic activity of the Colibactin toxin. The single-amino acid mutations of the ClbP gene in pks+ E. coli will be a genetic modification selected from the group consisting of S95A, S95R and K98T¹.

The phagemid will be contacted with pks+ E. coli in vitro. The growth of modified and non-modified E. coli will be tested in liquid and solid culture with routine culture techniques to determine the effect of the modifications on growth in vitro.

The phagemid vectors will be then produced in E. coli. to high titers and a pharmaceutical composition will be prepared.

The pharmaceutical composition will be administered to a subject mouse to generate in-situ genetic modification of the pks+ E. coli of the mouse.

Fecal samples will be collected at daily timepoints and tested by PCR and sequencing to quantitate the levels of modified and un-modified E. coli. to determine the percentages of each over time. The comparison of levels of modified and un-modified E. coli over time allows for screening for the genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth.

Example 4—Editing of Commensals Bacteria Expressing Ro60 Orthologue for Systemic Lupus Erythematosus (SLE) or Subacute Cutaneous Lupus Erythematosus (SCLE) Prevention or Treatment

A method to stop the apparition or progression of systemic lupus erythematosus (SLE) or subacute cutaneous lupus erythematosus (SOLE), by in situ genetic modification of the bacterial Ro60 orthologs, more specifically the epitopes of these orthologs.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacterial population results in amino acid mutations in the peptidic sequence of the bacterial Ro60 orthologs that decreases its homology with human Ro60 peptide, but maintains the activity of the enzyme. Multiple single-amino acid mutations are analyzed, starting with conservative mutations. The bacteriophage vector is produced to high titers and a pharmaceutical composition is prepared. The pharmaceutical composition is administered to human patients to generate in-situ genetic modification of the patient. The administration results in one or several amino acid mutations in epitope regions of R060 orthologue for one or several commensal bacteria such as Propionibacterium propionicum.

The mutation is one or several non-synonymous mutations in:

- the Ro60 B cell epitope (aa 169-190) (TKYKQRNGWSHKDLLRLSHLKP, SEQ ID NO: 16), more specifically the amino acid change will be in the bolded amino acids (TKYKQRNGWSHKDLLRLSHLKP, SEQ ID NO: 16).
- the Ro60 T cell epitope (aa 316-335) (KARIHPFHILIALETYKTGH, SEQ ID NO: 17) more specifically the amino acid change will be in the bolded amino acids (KARIHPFHILIALETYKTGH, SEQ ID NO: 17).
- the Ro60 T cell epitope (aa 369-383) (KRFLAAVDVSASMNQ, SEQ ID NO: 18) more specifically the amino acid change will be in the bolded amino acids (KRFLAAVDVSASMNQ, SEQ ID NO: 18).

A non-limiting list of human commensal bacteria whose genome contains a Ro60 ortholog is: Actinomyces massiliensis F0489 (HMPREF1318_2237), Actinomyces sp. Oral taxon 414 (AM609_00765), Corynebacterium amycolatum SK46 (CORAM0001_1910), Mycobacterium smegmatis (strain ATCC 700084/mc(2)155) (MSMEG_1193), Parascardovia denticolenslPLA 20019 (A200_07914), Propionibacterium prop F0230a (HMPREF9154_0590), Segniliparus rugosus ATCC BAA-974 (HMPREF9336_02315), Streptomyces sp. HGB0020 (HMPREF1211_06263), Bacteroides theta 7330 (Btheta7330_01248), Chryseobacterium gleum ATCC 35910 (HMPREF0204_10833), Prevotella sp. CAG:1092 (BN465_02442), Clostridium sp. BL8 (M918_10850), Paenibacillus sp. HGF7 (HMPREF9413_2200), Paenibacillus sp. HGH0039 (HMPREF1207_01859), Eikenella corrodens ATCC 23834 (EIKCOROL_00065), Kingella oralis ATCC 51147 (GCWU000324_03050), Neisseria elongata subsp. glycolytica ATCC 29315 (NEIELOOT_02899), Neisseria flavescens strain CD-NF1 (TV01_0020), Neisseria macacae ATCC 33926 (HMPREF9418_1500), Neisseria mucosa strain C6A (E517_04055), Neisseria shayeganii 871 (HMPREF9371_0707), Neisseria sicca ATCC 29256 (NEISICOT_02760), Neisseria sp. GT4A_CT1 (HMPREF1028_01178), Neisseria sp. oral taxon 020 str. F0370 (HMPREF9120_02756), Neisseria subflava NJ9703 (NEISUBOT_04391), Cardiobacterium valvarum F0432 (HMPREF9080_02018), Synergistes sp. 3_1_syn1 (HMPREF1006_01942).

More preferably the human commensal bacteria targeted by bacteriophage vector are: Propionibacterium propionicum, Corynebacterium amycolatum, Actinomyces massiliensis, Bacteroides thetaiotaomicron.

Example 5—Editing of Pathogenic Escherichia coli In Situ

E. coli is a commensal enterobacteria but specific strains have been associated with numerous pathology inside and outside the gut among which inflammatory bowel disease (IBD), urinary tract infection (UTI), Hemolytic uremic syndrome (HUS), Gastroenteritis or colorectal cancer. The pathogenicity of these specific strains originates from virulence genes some of which are acquired by horizontal gene transfer such as shiga toxin genes (stx) carried by temperate phages or by mutations in specific genes.

A method to reduce or abolish the pathogenic properties of the gut bacteria Escherichia coli by in situ genetic modification of peptidic sequence of virulence gene notably genes involved in the inflammatory properties of E. coli is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications. Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The phagemid contact the bacterial population resulting in the mutation of one or several non-synonymous mutations in:

- the FimH gene that results in reverting the following mutations: N70S and S78N associated with AEIC strains¹.
- the ChiA gene that results in reverting the following mutations: K362Q, K370E, A378V, E388V, V548E²⁴
- the OmpA gene that results in reverting the following mutation: A200V²⁵
- the OmpC gene that results in reverting the following mutation: V220I, D232A²⁵
- the OmpF gene that results in reverting the following mutation: E51V, M60K²⁵
- the blc gene in E. coli that results in reverting the following mutation G84E (G251A at the nucleotide level) potentially associated to gut inflammation⁴

Example 6—Editing of Staphylococcus epidermidis In Situ

Staphylococcus epidermidis is with Cutibacterium acnes one of the two most prevalent and abundant commensal bacteria on the human skin. As such it has been shown to prevent colonization by pathogenic bacteria like its close relative Staphylococcus aureus, prevent skin cancer or also modulate the human immune system. However, it is also a growing concern due to its opportunistic pathogenic characteristic and its growing resistance to antibiotics. These pathogenic traits of S. epidermis might be encoded on specific virulence genes or cluster and some of these might spread across strains by horizontal gene transfer.

A method to reduce or abolish the pathogenic properties of S. epidermidis by in situ genetic modifications of peptidic sequences of virulence genes is described below.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacterial population results in one or several genetic mutations that lead to reduction or elimination of the pathogenicity. This can be done by for example: non-synonymous mutations, mutations leading to gene disruption such as introduction of stop codons or mutations in regulatory sequences such as promoter, transcription binding sites.

The genetic mutations is targeted towards one or several genes associated with S. epidermidis infection as described in Méric et al²⁷and listed here: id1001_1081, SE_p608, SE0037, SE0038, SE_p609, id1001_1086, SE0058, SE_p205, SE_p603, SEA0027, SE0036, SE0033, SE0053, SE0055, SE_p522, SE_p610, SE_p611, id1001_1083, id1067_0124, id268_0008, SE0090, SE2153, id1001_0181, id1067_0123, id1074_1993, SE0023, SE0030, SE0103, SE0120, SE0129, SE_p607, SEA0003, id1001_2175, id1001_2181, SE0031, SE0069, SE0076, SE0107, SE0115, SE_p602, SE_p606, SEA0022, SEA0030, id2_1533, id1001_0179, id1001_0180, id1001_0186, id1001_0194, id1001_0203, id1001_2173, id1001_2184, id1001_2209, id1067_0125, id1067_0126, id1074_0268, id1075_0004, id1092_0129, SE0004, SE0020, SE0114, SE0127, SE0282, SE1013, SE1106, SE1292, SE2395, SE_p605, SEA0004, SEA0008, id1001_0187, id1001_2183, id1001_2208, id1021_0918, id1074_0267, SE0005, SE0021, SE0050, SE0063, SE0118, SE1588, SE1632, SE1920, SE_p507, SEA0002, SEA0020, SEA0021, id1001_0910, id1001_2159, id1001_2206, id1021_0613, id1032_2361, id1032_2362, id1067_0112, id1067_0226, id1067_0227, id1067_1124, id429_2314, SE0045, SE0051, SE0054, SE0101, SE0109, SE0112, SE0116, SE0119, SE0145, SE0175, SE0803, SE0852, SE1092, SE1102, SE1103, SE1107, SE1118, SE1128, SE1429, SE1455, SE1587, SE1607, SE1983, SE2011, SE2079, SE2208, SE2251, SE2260, SE2409, SE_p103, SE_p508, SE_p521, SEA0005, id1001_0007, id1001_0010, id1001_0183, id1001_0191, id1001_0199, id1001_0912, id1001_1283, id1001_2163, id1001_2164, id1001_2169, id1001_2174, id1001_2185, id1031_0178, id1067_0113, id1074_2138, id429_2315, id429_2316, id429_2317, id429_2319, SE0001, SE0009, SE0016, SE0032, SE0071, SE0102, SE0104, SE0106, SE0108, SE0111, SE0122, SE0146, SE0148, SE0182, SE0197, SE0230, SE0231, SE0240, SE0263, SE0273, SE0306, SE0629, SE0800, SE0804, SE0805, SE0815, SE0817, SE0825, SE0828, SE1037, SE1094, SE1096, SE1105, SE1458, SE1605, SE1606, SE1613, SE1728, SE1917, SE1919, SE1921, SE2160, SE2192, SE2220, SE2257, SE_p410, id1001_0011, id1001_0182, id1001_0190, id1001_1084, id1001_1085, id1001_1264, id1001_1972, id1001_1984, id1001_1986, id1001_2203, id1005_0195, id1005_1733, id1005_1734, id1021_0933, id1021_1637, id1021_1670, id1021_1674, id1031_0580, id1031_0911, id1031_0919, id1031_0920, id1031_0922, id1031_1192, id1067-0106, id1067-0107, id1067-0111, id1067_1095, id1067_1493, id1091_1647, id505_1243, SE0002, SE0003, SE0008, SE0010, SE0019, SE0034, SE0064, SE0105, SE0110, SE0128, SE0137, SE0140, SE0157, SE0162, SE0181, SE0183, SE0186, SE0191, SE0241, SE0248, SE0253, SE0254, SE0266, SE0268, SE0307, SE0331, SE0470, SE0692, SE0693, SE0694, SE0802, SE0806, SE0841, SE0917, SE1059, SE1083, SE1090, SE1104, SE1211, SE1459, SE1598, SE1628, SE1637, SE1649, SE1770, SE1772, SE1777, SE1872, SE1897, SE1900, SE1918, SE1925, SE1926, SE1927, SE1931, SE1985, SE2021, SE2042, SE2044, SE2045, SE2091, SE2124, SE2152, SE2193, SE2201, SE2221, SE2222, SE2244, SE2246, SE2250, SE2401, SE2403, SE2408, SE_p203, SE_p206, SE_p405, SE_p406, SE_p506, SEA0001, SEA0029, id2_1530, id1001_0188, id1001_0911, id1001_1285, id1001_1982, id1005_1719, id1021_0758, id1021_0930, id1021_1658, id1021_1663, id1021_2114, id1031_1153, id1031_1190, id1031_1202, id1031_1222, id1031_1428, id1067-1094, id1067-1098, id1067-1099, id1067-1106, id1067-1135, id1091_2272, id1120_2061, id262_0707, id262_0708, id304_0202, id53_0678, SE0013, SE0015, SE0022, SE0121, SE0126, SE0135, SE0142, SE0149, SE0152, SE0185, SE0194, SE0196, SE0212, SE0226, SE0232, SE0237, SE0242, SE0243, SE0259, SE0262, SE0269, SE0272, SE0274, SE0275, SE0276, SE0278, SE0279, SE0281, SE0299, SE0305, SE0355, SE0435, SE0456, SE0604, SE0673, SE0689, SE0701, SE0704, SE0705, SE0707, SE0716, SE0779, SE0782, SE0808, SE0814, SE0818, SE0836, SE0839, SE0990, SE1082, SE1097, SE1108, SE1109, SE1122, SE1136, SE1138, SE1196, SE1207, SE1288, SE1456, SE1464, SE1546, SE1574, SE1580, SE1585, SE1589, SE1603, SE1604, SE1643, SE1735, SE1773, SE1827, SE1836, SE1899, SE1914, SE1915, SE1938, SE1946, SE2005, SE2022, SE2036, SE2041, SE2043, SE2052, SE2071, SE2074, SE2090, SE2116, SE2148, SE2149, SE2154, SE2167, SE2175, SE2194, SE2198, SE2199, SE2210, SE2215, SE2223, SE2225, SE2229, SE2259, SE2306, SE2314, SE2333, SE2337, SE2342, SE2379, SE2388, SE2394, SE_p411, SEA0006, id1001_0185, id1001_2167, id1001_2190, id1005_0702, id1005_0703, id1005_0704, id1005_1752, id1021_0787, id1021_1631, id1021_1651, id1021_1652, id1021_1667, id1021_1669, id1021_1671, id1021_1673, id1031_1154, id1031_1160, id1031_1169, id1031_1173, id1031_1179, id1031_1182, id1031_1431, id1031_2369, id1032_2377, id1036_1869, id1036_1871, id1067_1096, id1067_1097, id1067_1104, id1067_1117, id1067_1130, id1068_0108, id1068_0584, id1074_1751, id1074_2133, id1091_2269, id1092_1189, id267_0755, id324_1262, SE0014, SE0066, SE0117, SE0123, SE0134, SE0144, SE0163, SE0180, SE0195, SE0223, SE0229, SE0250, SE0251, SE0255, SE0261, SE0280, SE0301, SE0410, SE0444, SE0450, SE0455, SE0615, SE0637, SE0657, SE0663, SE0664, SE0669, SE0670, SE0683, SE0684, SE0690, SE0700, SE0706, SE0713, SE0785, SE0790, SE0797, SE0813, SE0816, SE0832, SE0909, SE1075, SE1080, SE1085, SE1089, SE1121, SE1132, SE1133, SE1175, SE1183, SE1184, SE1210, SE1212, SE1311, SE1348, SE1397, SE1408, SE1442, SE1460, SE1470, SE1516, SE1577, SE1581, SE1629, SE1635, SE1726, SE1727, SE1779, SE1785, SE1932, SE1949, SE1953, SE1954, SE1957, SE1959, SE1978, SE2012, SE2019, SE2023, SE2037, SE2046, SE2053, SE2054, SE2075, SE2085, SE2087, SE2088, SE2093, SE2094, SE2095, SE2114, SE2186, SE2191, SE2197, SE2213, SE2228, SE2230, SE2232, SE2242, SE2245, SE2247, SE2252, SE2253, SE2255, SE2256, SE2258, SE2298, SE2380, SE2384, SE2393, SE2396, SE2397, SE2406, SE2407, SE2411, SE2412, SE2415, SE_p409, SEA0033, id2_0245, id1001_0986, id1001_2165, id1021_0310, id1021_1615, id1021_1628, id1021_1635, id1021_1638, id1021_1654, id1021_1655, id1021_1659, id1021_1668, id1031_1165, id1031_1170, id1031_1171, id1031_1172, id1031_1174, id1031_1178, id1031_1181, id1031_1183, id1031_1224, id1031_1432, id1032_2373, id1067_1146, id1068_0610, id1074_0173, id1121_0371, id267_0744, id267_0753, id268_1096, id277_0533, id277_0629, id284_0382, id312_1160.

Preferably the genetic mutations is targeted towards one or several genes associated with S. epidermidis infection in the following list: SE0023, SE0101, SE0121, SE0128, SE0275, SE0281, SE0307, SE1105, SE1128, SE1459, SE2197, SE2245, SE2259, SE_p521, id1001_2159, id1068_0108, id1091_1647, SE0197, SE0704, SE0705, SE0706, SE0707, SE1632, SE2201, id1001_0010, SE0004, SE0030, SE0031, SE0033, SE0036, SE0050, SE0053, SE0055, SE0076, SE0090, SE0111, SE1897, id1067_0123, id1067_0124, id1067_0125, id1067_0126, id1067_0226, id1067_0227, SE0102, SE0103, SE0104, SE0105, SE0106, SE0107, SE0108, SE0110, SE0117, SE0157, SE0175, SE0673, SE0818, SE0828, SE1311, SE1637, id1067_1493, id324_1262.

Example 7—Base Editing of mCherry on the E. coli Genome after Transformation In Vitro

This example presents a method for the base editing of the nucleic acid sequence encoding fluorescent protein mCherry (SEQ ID NO: 5) on the E. coli MG1655 genome after transformation with a DNA payload encoding a base editor. Fluorescence was measured by flow cytometry of individual colonies after transformation and overnight selection on chloramphenicol plates.

As shown on FIG. 4A, the adenine base editor ABE8e (SEQ ID NO: 1, plasmid map shown on FIG. 7) deactivated the active site of mCherry (tripeptide: M71, Y72, G73) while enabling the translation of the full-length protein.

As shown on FIG. 4B, the cytosine base editor (evoAPOBEC1-nCas9-UGI; SEQ ID NO: 3, plasmid map shown on FIG. 8) inserted a stop codon (Q114) into the target gene mCherry resulting in the loss of fluorescence.

As a control, base editors were transformed in the absence of a guideRNA (2 colonies analysed) leading to fluorescent mCherry expression.

All of the 48 analysed colonies targeting mCherry via the same guideRNA were successfully edited, leading to a loss of fluorescence. The mCherry gene of five colonies was sequenced, which confirmed successful base editing.

Example 8—Base Editing of β-Lactamase on the E. coli Genome after Packaged Phagemid Transduction In Vitro

This example presents a method for the base editing of the nucleic acid sequence encoding β-lactamase (SEQ ID NO: 6) on the E. coli MG1655 genome after packaged phagemid transduction in vitro. As shown on FIG. 5A, production of packaged lambda phagemids (within a bacterial delivery vehicle comprising an A8 gpJ protein and a P2 STF protein enabling transduction into MG1655 strain) encoding a base editor (ABE or CBE) and a transcribed guideRNA targeting the active site of the β-lactamase gene (K71E) on the genome, and further carrying a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication, resulted in titers of ˜10⁸transduction units (tu) per μl.

Cells were plated on carbenicillin plates 2 hours post transduction in order to analyse base editing efficiency.

As shown on FIG. 5B, the efficiency of adenine base editing (using ABE8e; SEQ ID NO: 2) targeting the active site of the β-lactamase gene (K71E) on the genome was multiplicity of infection (MOI)-dependent. The efficiency of cytosine base editing (using evoAPOBEC1-nCas9-UGI; SEQ ID NO: 4) inserting a stop codon into the β-lactamase gene on the bacterial genome was also MOI-dependent (FIG. 5C). ABE or CBE resulted in ˜4 log or ˜3 log reduction of cell growth at high MOIs, respectively.

Example 9—Adenine Base Editing of β-Lactamase after Transduction into E. coli in oligoMM Mice In Vivo

This example presents a method for the adenine base editing (using ABE8e, SEQ ID NO: 2) of a target gene (β-lactamase; SEQ ID NO: 6) after phagemid transduction into E. coli in an oligo-mouse-microbiota model in vivo.

The packaged phagemid titer (within a bacterial delivery vehicle comprising an A8 gpJ protein and a P2 STF protein enabling transduction into MG1655 strain) for the in vivo experiment was 1.5×10⁹transduction units per μl (tu/μl). Said phagemid carries the expressed adenine base editor ABE8e under the SrpR promoter and a constitutively transcribed guideRNA targeting the active site of the β-lactamase gene (K71E) on the genome. Furthermore, said phagemid carries a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication.

An E coli strain carrying the β-lactamase gene was administered to 10 individual mice aged 7 weeks at 10⁷CFU per mouse. Two packaged phagemid doses (100 μl packaged phagemid+100 μl sucrose bicarbonate per mouse) were orally administered to the mice at 0 h and 30 h. Stool samples were analysed 0, 6, and 48 hours post initial phagemid transduction (48, 96, 88 colonies, respectively).

Cells were plated on streptomycin, chloramphenicol, and carbenicillin plates in order to analyse delivery and editing efficiency. Editing of the active site of β-lactamase (K71E) resulted in a loss of cell growth on carbenicillin plates.

As shown on FIG. 6, after 48 hours, ˜49% of the targeted bacteria population carried the DNA payload and ˜30% of the whole population were base edited in vivo. The percentage of payload delivery could be further increased by higher phagemid titers and/or cumulative doses.

Example 10—Prime Editing of Red Fluorescent Protein (RFP) on the E. coli Genome In Vitro

This example presents a method for the prime editing of the nucleic acid sequence encoding the Red Fluorescent Protein RFP (SEQ ID NO: 2314) on the E. coli genome after transformation with a DNA payload (FIG. 9). The payload encodes a prime editor (PE; payload of sequence SEQ ID NO: 2315), a transcribed prime editing guide RNA (pegRNA), a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication. The pegRNA consists of an extended single guide RNA containing a primer binding site and a reverse transcriptase sequence in order to replace RFP's amino acid E16 (GAA) with a stop codon (TAA) on the bacterial genome.

The prime editor (PE; payload of sequence SEQ ID NO: 2315) was engineered to insert a stop codon at position E16 of the target gene RFP resulting in a loss of red fluorescence.

As a control, the prime editor was transformed in the absence of a pegRNA leading to fluorescent RFP production.

The genomic RFP gene was amplified from 18 individual colonies after transformation and overnight selection on chloramphenicol plates. The resulting PCR fragments were sequenced and the editing efficiency calculated.

As shown in FIG. 9, the stop codon was present in four of these individual colonies (˜22% of the bacterial population) confirming successful prime editing.

Example 11: Description of the System Used for Non-Replicative Payloads

The inventors developed a system in which the payload contains the 282-bp primase origin and the primase protein is supplied in trans (SEQ ID NO: 8 and SEQ ID NO: 14). To simplify the engineering process, the PICI primase gene was extracted from the genome of E. coli CFT073, cloned into a plasmid under the control of an inducible system and an RBS (ribosome-binding site) library generated. This series of plasmids were cloned in the lambda production strain s1965. Next, the inventors constructed a small payload harboring the primase-ori instead of the p15a-based origin of replication to yield a 2.3 kb payload. Since this plasmid is, in principle, non-replicative, competent cells of s1965 harboring the RBS library of inducible primase constructs were made, the plasmid transformed in them and plated in LB agar+kanamycin and chloramphenicol in the presence of the inducer DAPG (to induce the expression of the primase in trans). Next day, the inventors observed that the plates contained hundreds of colonies, suggesting that the primase-origin system in trans works (FIG. 11).

Several clones were sequenced to verify that the plasmid contained no p15a-based origin and that they also contained an intact primase gene with an RBS coming from the library.

After that, 7 of these clones were grown overnight and lambda productions were carried out in the presence of kanamycin, chloramphenicol and DAPG. As a control, the inventors included the original 2.8 kb plasmid containing a derivative of the p15a origin of replication to compare titers.

To verify the sequence of the RBS variants obtained, the plasmid encoding the inducible primase in the 7 clones tested was miniprepped and sequenced. They were also transformed into MG1655 cells (s003): these strains were used to verify the titers obtained, since the payloads should not be replicative in the absence of the primase protein supplied in trans.

As can be seen on FIG. 12, the titers of 5 out of 7 primase-containing samples, as measured in MG1655 containing the primase plasmid in trans, were the same as those of a packaged phagemid carrying the original modified p15a origin.

Finally, the inventors tested if the primase-ori containing payloads could replicate in MG1655 strains without the primase plasmid in trans. To do this, serial 5X dilutions of the primase-ori containing plasmids coming from the production strains with different primase RBS, plus a p15a-origin control, were transduced into a dense culture (OD600 ˜0.8) of MG1655 and plated on LB agar plates containing chloramphenicol. As can be seen on FIG. 13, while the p15a-origin control shows healthy colonies up to the last dilution, indicative of active plasmid replication, the samples containing the primase-containing payload show colonies only at high MOIs: since the strain will lose the payload by division, those drops that contained a high number of transduced bacteria will appear as dense spots since division will be halted at high cell densities; as the MOIs are reduced, the spots become more transparent and single colonies are hard to distinguish, indicative of cells that are dying due to plasmid loss and exposure to antibiotics. This is also indicative of a burst of expression of the chloramphenicol acetyltransferase gene upon transduction, which, in the absence of active replication, will get diluted over time; this may cause the receiver cells to survive for a certain amount of time until the intracellular concentration of chloramphenicol acetyltransferase drops below a critical level to support growth in antibiotic-supplemented media.

Example 12—Adenine Base Editing of β-Lactamase on the E. coli Genome after Packaged Phagemid Transduction In Vitro Using a Non-Replicative Payload

This example presents a method for the base editing of the nucleic acid sequence encoding β-lactamase (SEQ ID NO: 6) on the E. coli MG1655 genome after packaged phagemid transduction in vitro using a non-replicative payload based on a primase-helicase as disclosed in Example 11 (FIG. 10). The non-replicative payload consists of an adenine base editor (ABE8e), a transcribed guideRNA targeting the active site of the β-lactamase gene (K71E) on the genome, a lambda packaging sequence, a chloramphenicol resistance marker, and the conditional origin of replication (dependent on the presence of a primase-helicase) of sequence SEQ ID NO: 8. Production of lambda phagemids, packaged inside a bacterial delivery vehicle comprising an A8 gpJ protein and a p2 STF protein for delivery into E. coli MG1655, resulted in titers of 7.4×10⁷transduction units per μl (tu/μl).

Transduced cells were plated on LB and LB (carbenicillin) 2 hours post transduction at different multiplicity of infections (MOI). The next day, base editing efficiency was analyzed via colony counting.

As can be seen on FIG. 10, the efficiency of adenine base editing targeting the active site of the β-lactamase gene (K71E) on the genome was multiplicity of infection (MOI)-dependent. A base editing efficiency of >4 logs was obtained at high MOIs using the non-replicative payload, confirming the efficiency of base editing even using a conditional origin of replication which prevents replication of the payload inside the targeted E. coli MG1655 bacteria.

Example 13—Base Editing of β-Lactamase on the E. coli Genome after Phagemid Transduction in oligoMM Mice In Vivo Using a Non-Replicative Payload Based on a Primase-Helicase

This example presents a method for the adenine base editing (ABE8e-primase, SEQ ID NO: 2) of a target gene (e.g. β-lactamase; SEQ ID NO: 6) after packaged phagemid transduction in vivo into E. coli in an mouse colonization model. The packaged phagemids titer for the in vivo experiment was 1.5×10¹⁰transduction units per μl (tu/μl) after purification.

An E. coli strain carrying the β-lactamase gene in the genome was orally administered to 10 female mice aged 7 weeks at 10⁷CFU per mouse. A packaged phagemids dose of 1.5×10¹²to (ie 100 μl, buffered with 100 μl of sucrose bicarbonate) was orally administered to the mice (TO). Stool samples were collected immediately before this administration, as well as 24 hours after (T24h). Stool homogenates were plated on selective medium, and individual clones were further repatched on agar plates with or without carbenicillin in order to analyse editing efficiency (20 colonies per mouse and per time point). Editing of the active site of β-lactamase (K71E) resulted in a loss of bacterial growth on carbenicillin plates. At T24h, ˜75% of the whole population was base-edited on average (see FIG. 14).

Example 14—Prime Editing of β-Lactamase on the E. coli Genome after Phagemid Transduction In Vitro

This example presents a method for the prime editing of the nucleic acid sequence encoding the Red Fluorescent Protein RFP (SEQ ID NO: 2314) on the E. coli genome after transduction with a DNA payload. The payload (SEQ ID NO: 2325) encodes a prime editor (PE), a transcribed prime editing guide RNA (pegRNA) under the inducible promoter pBetI, a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication. The pegRNA consists of an extended single guide RNA containing a primer binding site and a reverse transcriptase sequence in order to replace RFP's amino acid E16 (GAA) with a stop codon (TAA) on the bacterial genome.

The prime editor was engineered to insert a stop codon at position E16 of the target gene RFP resulting in a loss of red fluorescence.

Production of packaged phagemids comprising an A8 gpJ protein and a p2 STF protein for delivery into E. coli MG1655, resulted in titers of 2.6×10⁷transduction units per μl (tu/μl).

The fluorescence of colonies was analyzed by flow cytometry after overnight selection on chloramphenicol and 10 mM choline chloride and repatching on chloramphenicol plates. The genomic RFP was amplified from non-fluorescent colonies and the resulting PCR fragments were sequenced and the editing efficiency calculated. The stop codon was present in one of these individual colonies confirming successful prime editing after phagemid transduction.

Example 15—Editing of E. faecalis, E. Faecium and/or L. brevis Expressing Tyrosine Decarboxylase for Preventing L-DOPA Inactivation when Treating Subjects Suffering from Parkinson's Disease

In recent years, it was shown that the microbial decarboxylases that are part of gut microbial organisms appear to be able to metabolise L-DOPA (levodopa). Novel bacterial L-DOPA metabolism by tyrosine decarboxylases (tyrDCs) has been identified, dominantly driven by Enterococcus faecalis (Maini Rekdal et al. Science 2019; 364) but also E. faecium and L. brevis. Mutating these tyrDCs in E. faecalis, E. faecium and/or L. brevis can block this bacterial L-DOPA-to-dopamine metabolism, thereby improving drug efficacy.

A method to prevent the expression of a functional tyrosine decarboxylase of Enterococcus faecalis, E. faecium and/or L. brevis by in situ genetic modification of the gene sequence encoding said tyrosine decarboxylase is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a prime editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications, and a transcribed guideRNA targeting the catalytic site of tyrosine decarboxylase. The guideRNA is designed to introduce a stop codon in the catalytic site of said enzyme, rendering it inactive.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The phagemid contacts the bacterial population resulting in at least one mutation resulting a stop codon in the catalytic site of tyrosine decarboxylase.

Treating patients suffering from Parkison's disease with L-DOPA in combination with such packaged phagemids leads to a better efficacy of L-DOPA.

Example 16—Editing of Clostridium sporogenes Expressing DHPAA Synthase for Preventing L-DOPA Deamination when Treating Subjects Suffering from Parkinson's Disease

Levodopa is absorbed in the small intestine, however, 9-10% of unabsorbed “residual” L-dopamine is metabolised further down in the gut (this percentage increases with age and administered drug dose). The metabolite that results from this reaction—DHPPA—affects gut motility and constipation. This deamination can be mediated by Clostridium sporogenes which expresses DHPAA synthase. Constipation is a known side effect of Levodopa and inhibitors of this deamination could be beneficial.

A method to prevent the expression of a functional DHPAA synthase of C. sporogenes by in situ genetic modification of the gene sequence encoding said DHPAA synthase is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a prime editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications, and a transcribed guideRNA targeting the catalytic site of DHPAA synthase The guideRNA is designed to introduce a stop codon in the catalytic site of said enzyme, rendering it inactive.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The phagemid contacts the bacterial population resulting in at least one mutation resulting in a stop codon in the catalytic site DHPAA synthase.

Treating patients suffering from Parkison's disease with L-DOPA in combination with such packaged phagemids leads to reduced side effects, in particular reduced constipation.

TABLE 1

Gut bacterial species carrying candidate mimic peptide, amino acids sequence of related

mimic peptide and Uniprot ID of bacterial and human protein containing each mimic peptide

Uniprot ID of
Uniprot ID of

bacterial protein
human protein

SEQ
Candidate mimic
Gut Bacterial species carrying
containing mimic
containing

ID NO:
peptide
candidate mimic peptide
peptide
mimic peptide

19
AAAKHLTPV

Pseudomonas putida

Q84DC3
P51648

20
AACEAAVGL

Desulfovibrio desulfuricans

B8J1D0
P03901

21
AAGMNAAVR

Lactobacillus salivarius

Q1WTT3
Q01813

22
AAHGNSLRGI

Parabacteroides distasonis,

A6L9K8, B2RHB7,
P15259

Porphyromonas gingivalis,

Q7MXP1

Porphyromonas gingivalis

23
AALGSDTGGS

Lactobacillus casei, Lactobacillus

B3WD57, Q03AC0,
Q9H0R6

casei, Lactobacillus johnsonii,

Q74152, Q041KS,

Lactobacillus gasseri, Lactobacillus

Q5FLL1, A8YTZ6,

acidophilus, Lactobacillus helveticus,

Q04BV7, Q1GBF4,

Lactobacillus delbrueckii,

C4Z3J4, A0RNK4,

Lactobacillus delbrueckii,

Q9ZL13, Q9JYZ9,

Eubacterium eligens, Campylobacter

Q5F8U8, B4RM85,

fetus, Helicobacter pylori, Neisseria

A1KUH8, A9M003,

meningitidis, Neisseria gonorrhoeae,

Q03EG5

Neisseria gonorrhoeae, Neisseria

meningitidis, Neisseria meningitidis,

Pediococcus ntosaceus

24
AAPFGGVKQSG

Rhizobium sp.
P55653
Q3SY69

25
AAPGSKTTQ

Aeromonas salmonicida, Aeromonas

A4SMI9, A0KKI5,
Q08J23

hydrophila, Citrobacter koseri,

A8AFL6, A4WBJ4,

Enterobacter sp., Escherichia coli,
Q0TGZ7, Q8FGS9,

Escherichia coli, Escherichia coli,

Q1RAV2, A1ACO0,

Escherichia coli, Escherichia coli,

B7MBP2, B7USL2,

Escherichia coli, Escherichia coli,

P76273, B1XHA3,

Escherichia coli, Escherichia coli,

C4ZZJ2, B6IBR3,

Escherichia coli, Escherichia coli,

B7M2B1, B7MVW5,

Escherichia coli, Escherichia coli,

B7L7N7, A7ZMV8,

Escherichia coli, Escherichia coli,

B7NBI3, B1LD37,

Escherichia coli, Escherichia coli,

B7NS84, B5YQX9,

Escherichia coli, Escherichia coli,

Q8XCL9, B7LPL0,

Escherichia fergusonii, Escherichia

B1J0Q3, A8A133,

coli, Escherichia coli, Klebsiella

A6TB06, B5X035

pneumoniae, Klebsiella pneumoniae

26
AAPGTIRGD

Parabacteroides distasonis

A6LCB6
O00746

27
AAPGTIRGDF

Streptococcus uberis, Streptococcus

B9DSE2, Q5M011,
O00746

thermophilus, Streptococcus

Q5M4M4

thermophilus

28
AAVEMRDNP

Enterobacter sp., Escherichia coli,
A4W6W8, Q1RFU0,
Q9UBT6

Escherichia coli, Escherichia coli,

Q0TL85, A1A7U2,

Escherichia coli, Escherichia coli,

Q47155, B1J100,

Escherichia coli, Escherichia coli,

A7ZHZ2, P59477,

Escherichia coli, Escherichia coli,

A7ZWJ6, Q8X7Q1,

Escherichia fergusonii

P58963

29
AAVPSGASTG

Clostridium botulinum, Clostridium

C1FQW6, A7FQP0,
P06733

botulinum, Clostridium botulinum,

B1IDB9, A7G9Y3,

Clostridium botulinum, Clostridium

B1KTJ8, C3KZ49

botulinum, Clostridium botulinum

30
ACGTSYHAG

Listeria innocua, Listeria

Q92DS8, Q722H1,
Q06210

monocytogenes, Listeria

Q8Y915, Q88BX8,

monocytogenes, Pseudomonas

Q87TT8

putida, Pseudomonas syringae

31
ADFIGKQAL

Listeria innocua

Q92C06
Q9UI17

32
ADIGWITGH

Helicobacter pylori, Helicobacter

B5Z6E9, Q17WR1,
Q9NUB1

acinonychis, Helicobacter pylori

O25686

33
ADIITPNQFE

Corynebacterium diphtheriae

Q6NG19
O00764

34
ADIVTTTTHKTLRG

Lactobacillus acidophilus

Q5FMC0
P34897

35
ADVGLVGFP

Corynebacterium urealyticum,

B1VGL9, Q03YT6,
A4D1E9

Leuconostoc mesenteroides,

B1N057

Leuconostoc citreum

36
ADVGLVGFPN

Desulfitobacterium hafniense,

B8FUR9, Q24SP0,
A4D1E9

Desulfitobacterium hafniense,

Q892N8

Clostridium tetani

37
ADVGLVGFPNAG

Bacteroides thetaiotaomicron,

Q89ZI9, A6LD68,
A4D1E9

KS

Parabacteroides distasonis,

A6L100, Q64XA5,

Bacteroides vulgatus, Bacteroides

Q5LGG9, Q7MW55,

fragilis, Bacteroides fragilis,

B2RIY7

Porphyromonas gingivalis,

Porphyromonas gingivalis

38
ADYLWNVSSPNT

Kocuria rhizophila, Streptomyces

B2GHT4, Q9KXR7,
Q02127

coelicolor, Streptomyces griseus,

B1W464, Q827Q6

Streptomyces avermitilis

39
AEAYDVLSDP

Porphyromonas gingivalis,

Q9XCA6, B2RLJ0
P59910

Porphyromonas gingivalis

40
AEDYHQQYL

Corynebacterium efficiens,

Q8FLU6, Q8NLL5,
Q9UJ68

Corynebacterium glutamicum,

A4QHY3, Q9APY4

Corynebacterium glutamicum,

Corynebacterium melassecola

41
AEIETDKAT

Rhizobium meliloti, Rhizobium meliloti

Q9R9N3, Q9R9N4
P10515

42
AESGWDFSSRW

Ralstonia solanacearum

Q8XT38
O43280

43
AESWDNVGLL

Staphylococcus epidermidis,

Q8CSD9, Q5HNY9,
Q9GZT8

Staphylococcus epidermidis,

Q6G907, Q8NWB9,

Staphylococcus aureus,

P67273, P67272,

Staphylococcus aureus,

Q5HFK1, Q6GGE0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

44
AETEAQRRQA

Methylobacterium sp.
B0UJI9
Q969Y2

45
AFDRILASRMG

Haemophilus influenzae,

P43863, A5UD89,
Q01813

Haemophilus influenzae,

Q4QLS8

Haemophilus influenzae

46
AFDRILASRMGV

Haemophilus parasuis

B8F8G9
Q01813

47
AFGFMTRVA

Ralstonia pickettii

B2UGY6
P61457

48
AFGFMTRVAL

Ralstonia solanacearum

Q8XU38
P61457

49
AFLTVSGQL

Enterobacter sp., Haemophilus
A4W8U9, Q7VLL7
Q96159

ducreyi

50
AFMLPVATPPNAI

Haemophilus influenzae

Q57486
Q86YT5

VF

51
AGAESGWDFSSR

Pseudomonas aeruginosa

Q9I165
O43280

WL

52
AGAMENWGLVTY

Lactobacillus helveticus, Lactobacillus

Q10730, P37896
P15144

RE

delbrueckii

53
AGASLVQLY

Pseudomonas stutzeri, Pseudomonas

A4VM41, Q4KFI7,
Q02127

fluorescens, Pseudomonas

C3K017

fluorescens

54
AGASLVQLYT

Akkermansia muciniphila

B2UNA2
Q02127

55
AGDGTTTAT

Clostridium botulinum, Clostridium

Q8KJ24, Q891G4,
P10809

tetani, Clostridium novyi, Desulfovibrio

A0Q2T1, Q30YH6,

alaskensis, Desulfovibrio vulgaris,

A1VCQ0, Q72AL6

Desulfovibrio vulgaris

56
AGDGTTTATVL

Streptococcus agalactiae,

Q8CX00, Q3JYQ0,
P10809

Streptococcus agalactiae,

Q8CX22

Streptococcus agalactiae

57
AGDGTTTATVLA

Aeromonas salmonicida, Aeromonas

A4SR80, A0KGL1,
P10809

hydrophila, Aggregatibacter

P46398, Q65MZ8,

actinomycetemcomitans, Bacillus

Q5WJN4, A7Z207,

licheniformis, Bacillus clausii, Bacillus

A8FAG3, O50305,

methylotrophicus, Bacillus pumilus,

B9KCR7, A1W0K4,

Bacillus halodurans, Campylobacter

O69289, Q5HTP2,

lari, Campylobacter jejuni,

A8FMS6, A7H2F8,

Campylobacter jejuni, Campylobacter

A7I0W5, A7ZCV2,

jejuni, Campylobacter jejuni,

A8AMQ6, C5BDK5,

Campylobacter jejuni, Campylobacter

O66190, O66200,

hominis, Campylobacter concisus,

Q66198, A4W5N8,

Citrobacter koseri, Edwardsiella

Q19NJ4, Q1R3B6,

ictaluri, Enterobacter asburiae,

B1LQG4, B61615,

Enterobacter agglomerans,

B7NG81, B1ITQ5,

Enterobacter aerogenes,

P0A6F5, A8A7N9,

Enterobacter sp., Escherichia coli,
P0A6F6, B7MSV9,

Escherichia coli, Escherichia coli,

B1XDP7, C5A1D5,

Escherichia coli, Escherichia coli,

B5Z2F2, B7M804,

Escherichia coli, Escherichia coli,

B7NTK2, P0A6F7,

Escherichia coli, Escherichia coli,

B7LCO2, B7MKU8,

Escherichia coli, Escherichia coli,

B7UPW3, A7ZV12,

Escherichia coli, Escherichia coli,

A1AJ51, Q0T9P8,

Escherichia coli, Escherichia coli,

B3E8G0, A5U9V2,

Escherichia coli, Escherichia coli,

A5UH48, P43733,

Escherichia coli, Escherichia coli,

Q4QN05, B8F865,

Escherichia coli, Escherichia coli,

Q0I284, P31294,

Escherichia coli, Geobacter lovleyi,

Q9ZN50, B2UW12,

Haemophilus influenzae,

P42383, B6JPA7,

Haemophilus influenzae,

Q1CVE5, B5Z6D1,

Haemophilus influenzae,

Q17VC6, O66210,

Haemophilus influenzae,

B5Y368, A6TH53,

Haemophilus parasuis, Haemophilus

O66192, A0AKH5,

somnus, Haemophilus ducreyi,

Q9AGE6, Q71XU6,

Helicobacter pylori, Helicobacter

C1KX21, B8DH59,

pylori, Helicobacter pylori,

Q929V0, P48215,

Helicobacter pylori, Helicobacter

B4EXE2, Q4ZP20,

pylori, Helicobacter pylori,

Q48EI5, Q87X14,

Helicobacter acinonychis, Klebsiella

Q3K7L6, C3K1A0,

oxytoca, Klebsiella pneumoniae,

B0KFQ2, Q4K764,

Klebsiella pneumoniae, Kluyvera

A6VB57, B1J3K5,

intermedia, Listeria welshimeri,

A5W8M6, Q88N55,

Listeria monocytogenes, Listeria

Q02H55, P30718,

monocytogenes, Listeria

B7UZG3, Q8Y1P8,

monocytogenes, Listeria

O66214, O66212,

monocytogenes, Listeria innocua,

Q2KAU2, Q2JYW6,

Neisseria flavescens, Proteus

P35470, P35471,

mirabilis, Pseudomonas syringae,

Q1M3H2, Q9L691,

Pseudomonas savastanoi,

Q2KBZ7, P35469,

Pseudomonas syringae,

B5ZRD6, Q1MKX4,

Pseudomonas fluorescens,

Q2KAR0, Q930Y0,

Pseudomonas fluorescens,

Q9L690, P34939,

Pseudomonas putida, Pseudomonas

Q1MJF2, B2FIU9,

fluorescens, Pseudomonas

B4SKL8

aeruginosa, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa, Ralstonia

solanacearum, Raoultella

ornithinolytica, Raoultella planticola,

Rhizobium etli, Rhizobium etli,

Rhizobium meliloti, Rhizobium

meliloti, Rhizobium leguminosarum,

Rhizobium leguminosarum,

Rhizobium etli, Rhizobium meliloti,

Rhizobium leguminosarum,

Rhizobium leguminosarum,

Rhizobium etli, Rhizobium meliloti,

Rhizobium leguminosarum,

Rhizobium leguminosarum,

Rhizobium leguminosarum,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

58
AGEFTRRAF

Sphingomonas wittichii

A5VA82
Q969Y2

59
AGFSGHGFK

Bacillus sp., Bacillus sp.
P23342, P40859
Q9P0Z9

60
AGGQGTRLG

Staphylococcus saprophyticus,

Q49ZB5, Q4L846,
Q16222

Staphylococcus haemolyticus,

Q6GEQ8, Q7A0A0,

Staphylococcus aureus,

Q6G7E3, Q7A4A4,

Staphylococcus aureus,

Q99S95, Q2FEW1,

Staphylococcus aureus,

Q5HE34, Q2FW81,

Staphylococcus aureus,

Q2YYH4, Q5HM59,

Staphylococcus aureus,

Q8CNG6

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

61
AGGRYDGLV

Aeromonas salmonicida, Aeromonas

A4SP01, A0KJ45,
P12081

hydrophila, Enterobacter sp.,
A4WD92, B6I586,

Escherichia coli, Escherichia coli,

Q1R8L9, B1LNG9,

Escherichia coli, Escherichia coli,

P60906, B1IWE7,

Escherichia coli, Escherichia coli,

P60907, Q0TEX1,

Escherichia coli, Escherichia coli,

A1AE52, A8A320,

Escherichia coli, Escherichia coli,

B7M7L8, B1XAY9,

Escherichia coli, Escherichia coli,

C4ZX89, B7MYE9,

Escherichia coli, Escherichia coli,

B7NRG4, P60908,

Escherichia coli, Escherichia coli,

B5Z0Y3, B7MHZ9,

Escherichia coli, Escherichia coli,

A7ZPV7, B7LCQ4,

Escherichia coli, Escherichia coli,

B7UGW0, B7N6A2,

Escherichia coli, Klebsiella

B5XNL6, B4EZT2,

pneumoniae, Proteus mirabilis,

Q3K7B7, C3K1L3,

Pseudomonas fluorescens,

Q4ZX22, Q4K6V0,

Pseudomonas fluorescens,

Q88PJ6, B0KPI8,

Pseudomonas syringae,

A5VYT6, Q886Y9,

Pseudomonas fluorescens,

Q48LZ3, B1JDV7,

Pseudomonas putida, Pseudomonas

Q8DN46, B8ZPP6,

putida, Pseudomonas putida,

Q04I50, C1CU26,

Pseudomonas syringae,

A3CR40, C1CH52,

Pseudomonas savastanoi,

Q97NC9, B1I9T7,

Pseudomonas putida, Streptococcus

A8AZV0, B5E3C8,

pneumoniae, Streptococcus

C1CAV1, C1CNA0,

pneumoniae, Streptococcus

A4VT07, A4VZ92,

pneumoniae, Streptococcus

B2IN41, B9DW81,

pneumoniae, Streptococcus

Q3JYL6, P67486,

sanguinis, Streptococcus

P67485, C0MGD4

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus gordonii,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus suis, Streptococcus

suis, Streptococcus pneumoniae,

Streptococcus uberis, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus equi

62
AGGRYDGLVG

Acinetobacter baumannii,

B7I5G8, B0VKR7,
P12081

Acinetobacter baumannii,

B7H068, B0V5G6,

Acinetobacter baumannii,

Q6FEM2

Acinetobacter baumannii,

Acinetobacter baylyi

63
AGGVTVSYFEW

Bacillus subtilis, Bacillus subtilis

P50735, P39633
P49448

64
AGIMITASHNPK

Staphylococcus aureus,

Q6GDU9, Q7A3K7,
Q96G03

Staphylococcus aureus,

Q99RE2, Q5HD61,

Staphylococcus aureus,

Q2FVC1, Q2FE11,

Staphylococcus aureus,

Q8NUV4, Q6G6I3,

Staphylococcus aureus,

Q2YW66, Q49WH7,

Staphylococcus aureus,

Q4L9R5

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Staphylococcus haemolyticus

65
AGKLHTGRSRND

Lactobacillus reuteri, Lactobacillus

A5VJH2, B2G6Y7
P04424

QV

reuteri

66
AGLAVRDVSELTG

Rhizobium loti

Q98E57
P31939

FPE

67
AGLKEGDYI

Bacillus subtilis

O31754
Q8TCX5

68
AGNWTGEMVEE

Aeromonas hydrophila, Aeromonas

A0KN65, A4SJY8
P36959

LILSGADI

salmonicida

69
AGTIAGLNV

Campylobacter fetus, Helicobacter

A0RPW7, P55994,
P11021

pylori, Helicobacter pylori,

B6JPL0, Q1CV46,

Helicobacter pylori, Helicobacter

B5Z9P0, B2URT8,

pylori, Helicobacter pylori,

Q9ZMW4

Helicobacter pylori

70
AGVMITASHN

Lactobacillus reuteri, Lactobacillus

B2G638, A5VIK4,
Q6PCE3

reuteri, Lactobacillus brevis,

Q03SJ3, Q03GV0

Pediococcus ntosaceus

71
AGVPRKPGM

Methylobacterium sp.,
B0UCF0, B7KVX2,
P40926

Methylobacterium extorquens,

A9W386, B8IJB4,

Methylobacterium extorquens,

Q84FY8, B1LZN1,

Methylobacterium nodulans,

B1ZG93, Q9EYJ6,

Methylobacterium extorquens,

C3M9U0, B3PQ91,

Methylobacterium radiotolerans,

Q2K3E9

Methylobacterium populi, Rhizobium

meliloti, Rhizobium sp., Rhizobium

etli, Rhizobium etli

72
AGVTVVIVR

Neisseria gonorrhoeae, Neisseria

Q5F7A0, O34370,
Q9Y617

meningitidis, Neisseria meningitidis,

P57007, A1KV48

Neisseria meningitidis

73
AGVTVVIVRDDL

Lactobacillus helveticus

A8YW78
Q9Y617

74
AGYITPVPGGVGP

Ralstonia pickettii

B2UFY4
P13995

MT

75
AHGNSLRGI

Bacteroides fragilis, Bacteroides

Q5LAT7, Q64R85,
P15259

fragilis, Bacteroides thetaiotaomicron,

Q8A8R2, Q8A765

Bacteroides thetaiotaomicron

76
AHGTNPASA

Uncultured termite

B1GYV8
P23378

77
AHIDAGKTTTTER

Aeromonas salmon icida

A4SHV8
Q969S9

78
AHIDAGKTTTTERI

Arcobacter butzleri, Neisseria

A8EW86, Q9JX07,
Q969S9

L

meningitidis, Neisseria meningitidis,

A1KRH0, A9M3X0,

Neisseria meningitidis, Neisseria

Q9K1I8, Q5F553,

meningitidis, Neisseria gonorrhoeae,

B4RQX2

Neisseria gonorrhoeae

79
AHLGHVFPDGP

Escherichia coli, Escherichia coli,

B7M1J2, B1IPF3,
Q9Y3D2

Escherichia coli, Escherichia coli,

A8A0X0, B7MVQ9,

Escherichia coli, Escherichia coli,

B6IBJ9, B1LDV3,

Escherichia coli, Escherichia coli,

B7N5B4, C4ZZD4,

Escherichia coli, Escherichia coli,

P0A746, Q0TH50,

Escherichia coli, Escherichia coli,

B7L603, P0A747,

Escherichia coli, Escherichia coli,

B1XGN8, B5YQ71,

Escherichia coli, Escherichia coli,

B7NSZ8, P0A748,

Escherichia coli, Escherichia coli,

B7USF8, A7ZMP8,

Escherichia coli, Escherichia

B7MAY9, B7LQ21,

fergusonii, Klebsiella pneumoniae,

B5XS71, A6T7R0,

Klebsiella pneumoniae,

B1J4W5, Q1ID16,

Pseudomonas putida, Pseudomonas

Q4ZQC6, Q4K8U5,

entomophila, Pseudomonas syringae,

B0KUQ0, C3K735,

Pseudomonas fluorescens,

Q885Q1, Q48FR2,

Pseudomonas putida, Pseudomonas

Q3K935, Q88LQ6,

fluorescens, Pseudomonas syringae,

A5W756, A4XVB1,

Pseudomonas savastanoi,

Q91016, Q02NZ0,

Pseudomonas fluorescens,

B7UUZ9, A6V3R3,

Pseudomonas putida, Pseudomonas

Q92RA4

putida, Pseudomonas mendocina,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa, Rhizobium

meliloti

80
AHVDHGKTTL

Bacillus subtilis, Escherichia coli,

O07631, P32132,
Q7Z2Z2

Escherichia coli, Escherichia coli,

P0A3B3, P0A3B1,

Escherichia coli, Haemophilus

P0A3B2, P44910,

influenzae, Helicobacter pylori,

Q9ZLZ3, O25225

Helicobacter pylori

81
AIILATAGL

Bacillus cytotoxicus

A7GTE5
P08397

82
AIILATAGLQRMG

Bacillus cereus, Bacillus cereus,

B7JQ57, C1ETR0,
P08397

W

Bacillus thuringiensis, Bacillus

A0RJ81, C3L6Z5,

anthracis, Bacillus anthracis, Bacillus

Q81LC7, C3P9E9,

anthracis, Bacillus cereus, Bacillus

Q72ZW2, Q6HD62,

thuringiensis, Bacillus cereus, Bacillus

B7IIX5, Q633Y0,

cereus, Bacillus cereus, Bacillus

Q817R0, B7HE96,

cereus, Bacillus cereus, Bacillus

B9IZ39, B7HQM4,

cereus, Bacillus weihenstephanensis

A9VIT8

83
AIKWNFTKF

Bacillus subtilis

P52035
P36969

84
AIVNAANSSL

Fusobacterium nucleatum

Q8RHQ2
Q9B069

85
AIYDTMQYI

Desulfitobacterium hafniense,

Q24S49, C4Z1T6,
Q16740

Eubacterium eligens, Clostridium

A7FYI2, A7GIH2,

botulinum, Clostridium botulinum,

B1IND7, C1FLA6,

Clostridium botulinum, Clostridium

A5I6W1, B9E685,

botulinum, Clostridium botulinum,

A5N2K8, B1L1D7,

Clostridium kluyveri, Clostridium

B2TPB9, B2UX13,

kluyveri, Clostridium botulinum,

A0Q2L1, Q891J7,

Clostridium botulinum, Clostridium

Q0ST53, Q8XKK1,

botulinum, Clostridium novyi,

Q0TQK2

Clostridium tetani, Clostridium

perfringens, Clostridium perfringens,

Clostridium perfringens

86
AKALALGAS

Helicobacter pylori

Q9ZL14
P12268

87
AKEMHVGHLRS

Neisseria meningitidis, Neisseria

Q9JYM8, A1KUU4,
P54136

meningitidis, Neisseria meningitidis,

Q9JTM7, B4RL22,

Neisseria gonorrhoeae, Neisseria

Q5F835, B1VTB7,

gonorrhoeae, Streptomyces griseus,

Q82E68, Q9WX29

Streptomyces avermitilis,

Streptomyces coelicolor

88
AKEMHVGHLRSTII

Pseudomonas entomophila,

Q1IGB8, B1J2I3
P54136

G

Pseudomonas putida

89
AKKVLSVAVYNHY

Lactobacillus gasseri, Lactobacillus

Q042T7, A8YUS4,
O76031

KRI

helveticus, Lactobacillus johnsonii

Q74JU4

90
AKNTYGTGCF

Bacillus weihenstephanensis, Bacillus

A9VI58, Q6HMD5,
Q14409

thuringiensis, Bacillus cereus, Bacillus

B7HYU3, B7JCV9,

cereus, Bacillus anthracis, Bacillus

C3LCY4, Q63EX2,

cereus, Bacillus cereus, Bacillus

C1EKE4, A0RAP3,

thuringiensis, Bacillus cytotoxicus,

A7GLY7, B9IT52,

Bacillus cereus, Bacillus anthracis,

Q81U58, C3P2T3,

Bacillus anthracis, Bacillus cereus,

Q73CE0, Q9KDW8,

Bacillus halodurans, Ralstonia

B2UF87

pickettii

91
AKNTYGTGCFLL

Eubacterium rectale, Clostridium

C4ZGB4, B2TN12,
Q14409

botulinum, Clostridium botulinum,

B2V358, B8JOH2,

Desulfovibrio desulfuricans,

Q39V17, Q8Y6Z2,

Geobacter metallireducens, Listeria

B8DHL0, Q71ZD2,

monocytogenes, Listeria

C1KVI5, A0AIY7,

monocytogenes, Listeria

Q92BH6

monocytogenes, Listeria

monocytogenes, Listeria welshimeri,

Listeria innocua

92
AKRLCPQLI

Bacillus cereus, Bacillus anthracis

Q635E0, Q81M86
Q9UBT6

93
ALAAGNCVV

Citrobacter koseri, Enterobacter sp.
A8AGJ9, A4WAR9
P43353

94
ALAAGNCVVLKPS

Escherichia coli, Escherichia coli,

B6IAI9, B7LZ33,
P43353

EI

Escherichia coli, Escherichia coli,

A7ZLN7, B1IS15,

Escherichia coli, Escherichia coli,

A8A002, B7URJ0,

Escherichia coli, Escherichia coli,

P77674, B1XDF5,

Escherichia coli, Escherichia coli,

C4ZVI3, Q1RBX3,

Escherichia coli, Escherichia coli,

Q8FHK7, Q0THX6,

Escherichia coli, Escherichia coli,

A1AB46, B7MUN0,

Escherichia coli, Escherichia coli,

B7MMS8, B1LFH3,

Escherichia coli, Escherichia

B7L6F9, B7LR95,

fergusonii, Escherichia coli,

B7N4K1, B5Z0W0,

Escherichia coli, Escherichia coli

Q8X9W5

95
ALAAIFIAQ

Bacillus caldotenax

P24944
P43003

96
ALEKIRAGA

Rhizobium leguminosarum,

B5ZPH6, Q1MLT8,
Q02127

Rhizobium leguminosarum,

B3PNN8, Q2KCS8

Rhizobium etli, Rhizobium etli

97
ALEYGLPPT

Fusobacterium nucleatum

Q8RG52
Q15046

98
ALEYGLPPTAG

Acinetobacter baumannii,

B0VSE0, B0V9L5,
Q15046

Acinetobacter baumannii,

B7GXW0, A3M3D6,

Acinetobacter baumannii,

Q43990

Acinetobacter baumannii,

Acinetobacter baylyi

99
ALFGTIDSWL

Methylobacterium extorquens,

B7KN92, A9W8T7,
Q14409

Methylobacterium extorquens,

B1ZGW7

Methylobacterium populi

100
ALGSDTGGS

Lactobacillus plantarum, Eubacterium

Q88XP7, C4ZHB9
Q9H0R6

rectale

101
ALKAADVGI

Bacillus subtilis

O31688
Q9NQ11

102
ALKPMNCPGH

Ralstonia pickettii, Stenotrophomonas

B2UGJ8, B4SQH4
A2RTX5

maltophilia

103
ALKYHPDKN

Clostridium tetani

Q892R1
O75953

104
ALQTREQHI

Bacteroides thetaiotaomicron,

Q8A8M0, Q5LDN2,
P23378

Bacteroides fragilis, Bacteroides

Q64UQ7

fragilis

105
ALQTREQHIRR

Pseudomonas stutzeri, Pseudomonas

A4VRT4, Q88CI9
P23378

putida

106
ALREAQEEV

Citrobacter koseri, Enterobacter

A8AFP5, P43338,
P00O24

aerogenes, Klebsiella pneumoniae,

B5XQ60, A6TAY4

Klebsiella pneumoniae

107
ALRNRSNTP

Haemophilus parasuis, Proteus

B8F632, B4EYR8,
P06744

mirabilis, Rhizobium etli, Rhizobium

Q2KCY8, B3Q0A9,

etli, Rhizobium leguminosarum

B5ZNS9

108
ALRNRSNTPI

Edwardsiella ictaluri

C5B6Z1
P06744

109
ALVGPNGAGKS

Streptomyces coelicolor

Q9RKQ4
Q9UG63

110
ALVTGASGGIG

Rhizobium sp.
P72332
Q6UWP2

111
AMEGPTPVSAL

Streptomyces coelicolor

Q9XAR5
P03915

112
AMLACARIGA

Pseudomonas syringae,

Q885K7, Q4ZQG8,
Q9NUB1

Pseudomonas syringae,

Q48G09, Q88EH6,

Pseudomonas savastanoi,

A4VKA0, C3MAS0,

Pseudomonas putida, Pseudomonas

Q92KX2, Q82EL5

stutzeri, Rhizobium sp., Rhizobium

meliloti, Streptomyces avermitilis

113
AMLACARIGAVH

Citrobacter koseri, Escherichia coli,

A8AN29, Q8FAY8,
Q9NUB1

Escherichia coli, Escherichia coli,

Q8X5T5, P27550,

Pseudomonas aeruginosa, Rhizobium

Q9HV66, B3PS41,

etli, Rhizobium leguminosarum,

B5ZV36, Q2K2T1

Rhizobium etli

114
AMLTTFNEIDM

Staphylococcus saprophyticus

Q49XM4
P36957

115
AMVGDGIND

Bacillus subtilis

O32220
Q04656

116
ANASLLDEGTAAA

Akkermansia muciniphila,

B2UNH4, Q4K7Q8
P23378

EA

Pseudomonas fluorescens

117
ANDPDADRLAVA

Haemophilus influenzae

Q57290
Q96G03

118
ANFAVYTAL

Citrobacter koseri, Edwardsiella

A8AD38, C5BEV2,
P34896

ictaluri, Enterobacter sp., Escherichia
A4WDC0, B1LNK7,

coli, Escherichia coli, Escherichia coli,

Q1R814, B6I5C4,

Escherichia coli, Escherichia coli,

P0A825, A8A359,

Escherichia coli, Escherichia coli,

B1IV56, P0A826,

Escherichia coli, Escherichia coli,

Q0TET8, B1X1326,

Escherichia coli, Escherichia coli,

A1AE82, C4ZXC6,

Escherichia coli, Escherichia coli,

B7M8A7, B7MYI0,

Escherichia coli, Escherichia coli,

B7NRK2, B7LDE3,

Escherichia coli, Escherichia coli,

B7MIN5, A7ZPZ4,

Escherichia coli, Escherichia coli,

B7UGZ1, B5Z123,

Escherichia coli, Escherichia coli,

Q8XA55, B7N6D8,

Klebsiella pneumoniae, Klebsiella

A6TCG5, B5XNI6

pneumoniae

119
ANFLDVGGGA

Campylobacter hominis

A7I2F2
Q9P2R7

120
ANGPTTPEA

Staphylococcus aureus,

Q7A1B9, Q6GID0,
P49448

Staphylococcus aureus,

Q6GAW8, Q99VD0,

Staphylococcus aureus,

Q7A6H8, Q5HHC7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

121
ANGPTTPEAD

ptoclostridium difficile

P27346
P49448

122
ANMDTVGTF

Edwardsiella ictaluri, Enterobacter

C5B9H0, A4W6K6,
P36959

sp., Escherichia coli, Escherichia coli,
Q8X984, B5YZD9,

Escherichia coli, Escherichia coli,

A7ZHJ5, Q0TLN6,

Escherichia coli, Escherichia coli,

B7M145, Q1RG92,

Escherichia coli, Escherichia coli,

B6HZ81, P60560,

Escherichia coli, Escherichia coli,

B1IQN5, P60561,

Escherichia coli, Escherichia coli,

B1XC80, C4ZRJ8,

Escherichia coli, Escherichia coli,

A7ZW55, A1A7E7,

Escherichia coli, Escherichia coli,

B7MAM6, B7LFX2,

Escherichia coli, Escherichia coli,

B7UIF3, B7N7X5,

Escherichia coli, Escherichia coli,

B7NI65, B7MNW1,

Escherichia coli, Escherichia

B1LG40, B7LWQ6,

fergusonii, Klebsiella pneumoniae,

B5Y1T3, A6T4P6

Klebsiella pneumoniae

123
ANMDTVGTFEMA

Citrobacter koseri

A8ALJ2
P36959

124
APALACGNA

Pseudomonas sp.
Q9KWS5
P49189

125
APGRVNLIGEHTD

Aeromonas hydrophila, Bacillus

A0KQH8, P39574,
P51570

YN

subtilis, Bacillus halodurans,

Q9KDV4, A8AJ37,

Citrobacter koseri, Enterobacter sp.,
A4W899, B7MPP1,

Escherichia coli, Escherichia coli,

B1LM48, B7N9Z9,

Escherichia coli, Escherichia coli,

B7ULN0, B7LK02,

Escherichia fergusonii, Escherichia

B617R1, P0A6T3,

coli, Escherichia coli, Escherichia coli,

B1IXX9, C4ZXS8,

Escherichia coli, Escherichia coli,

B7M6C0, B5YRF5,

Escherichia coli, Escherichia coli,

P0A6T4, B7LAF8,

Escherichia coli, Escherichia coli,

A7ZJD2, B7NNH9,

Escherichia coli, Escherichia coli,

Q1REH4, Q8FJS1,

Escherichia coli, Escherichia coli,

Q0TJU4, A1A900,

Escherichia coli, Escherichia coli,

B7MGL4, A7ZY13,

Escherichia coli, Proteus mirabilis,

B4F0A6, Q9K3S8

Streptomyces coelicolor

126
APGTGTPEI

Pseudomonas aeruginosa

Q9I6K2
Q9BSE5

127
APIFHVNADDPEA

Escherichia coli, Escherichia coli,

P0AFG3, P0AFG5,
Q9ULD0

V

Escherichia coli

P0AFG4

128
APSDMMDGR

Clostridium josui

Q59295
P13716

129
APSPTGFLH

Lactobacillus reuteri, Lactobacillus

B2G868, A5VKT4,
Q5JPH6

reuteri, Listeria monocytogenes,

Q724H5, Q8YAB3,

Listeria monocytogenes, Listeria

A0AF36, Q92F38

welshimeri, Listeria innocua

130
APTGSGKTLA

Escherichia coli

P30015
Q9Y2R4

131
APTRELAQQ

Bacillus cereus, Staphylococcus

Q818H2, Q2FY15
Q92841

aureus

132
AQEALGDVV

Pseudomonas aeruginosa,

Q9HTX6, Q88CI8,
P23434

Pseudomonas putida, Pseudomonas

Q88AR9

syringae

133
AQLSGGQKQR

Pseudomonas aeruginosa,

Q02ME3, Q9I1C8,
Q2M3G0

Pseudomonas aeruginosa,

Q4KK46, Q3KJS6,

Pseudomonas fluorescens,

Q87UN4, Q4ZZR8,

Pseudomonas fluorescens,

Q48PU6, Q827Y0

Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas savastanoi,

Streptomyces avermitilis

134
AQLSGGQKQRV

Pseudomonas savastanoi,

Q48PN3, Q3KK97,
Q9NP78

Pseudomonas fluorescens,

Q4ZZK0, Q87UV4,

Pseudomonas syringae,

Q9L1C3

Pseudomonas syringae,

Streptomyces coelicolor

135
AQSIGEPGTQ

Desulfovibrio alaskensis,

Q30X04, A1VAJ5,
O14802

Desulfovibrio vulgaris, Desulfovibrio

Q727C6, B3E7S9,

vulgaris, Geobacter lovleyi, Geobacter

B5EFP4, C6E4R3,

bemidjiensis, Geobacter sp.,
B9M6V1, A5GAY2,

Geobacter daltonii, Geobacter

Q40N34, A5U9X9,

uraniireducens, Haemophilus

A5UH19, P43739,

influenzae, Haemophilus influenzae,

Q7VKL8, Q8XUZ9,

Haemophilus influenzae,

B2FQ39

Haemophilus influenzae,

Haemophilus ducreyi, Ralstonia

solanacearum, Stenotrophomonas

maltophilia

136
ARGLDYYTG

Bifidobacterium longum,

B7GPS9, Q8G864,
P12081

Bifidobacterium longum,

B8DU04, Q892X7,

ifidobacterium animalis, Clostridium

B2FPL6, B4STN3

tetani, Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

137
ARLNFSHGSHE

Staphylococcus aureus,

Q6GG09, Q7A0N4,
P30613

Staphylococcus aureus,

Q5HF76, Q6G8M9,

Staphylococcus aureus,

Q2FXM9, Q99TG5,

Staphylococcus aureus,

Q7A559, Q2FG40,

Staphylococcus aureus,

Q2YTE3, Q8CS69,

Staphylococcus aureus,

Q5HNK7, Q4L739

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus

138
ARMTAMDNA

Clostridium cellulolyticum

B81578
P36542

139
ARVYKQSDL

Campylobacter fetus

A0RR73
P00480

140
ASFITPVPGGVGP

Bacillus methylotrophicus, Bacillus

A7Z6J9, P54382
P11586

MT

subtilis

141
ASFITPVPGGVGP

Aeromonas hydrophila, Aeromonas

A0KJD4, A4SNM0
P11586

MTVA

salmonicida

142
ASFITPVPGGVGP

Haemophilus somnus

Q0I3S5
P11586

TVAMLM

143
ASGAGGQHVN

Enterococcus faecalis

Q831F6
Q9UGC7

144
ASGPLVRSSY

Pseudomonas fluorescens,

C3K2L8, A6V0B4,
O43766

Pseudomonas aeruginosa,

B1J144, Q3K6A4,

Pseudomonas putida, Pseudomonas

Q1I4G1, B7V9C1,

fluorescens, Pseudomonas

Q9HX25, Q02SG3,

entomophila, Pseudomonas

Q88DM5, A5W9I5,

aeruginosa, Pseudomonas

Q87WV7, Q4ZN84,

aeruginosa, Pseudomonas

Q48DM6, A4VQZ6

aeruginosa, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

syringae, Pseudomonas syringae,

Pseudomonas savastanoi,

Pseudomonas stutzeri

145
ASKNASEMI

Geobacter lovleyi

B3EA02
P36542

146
ASKPLKGARI

Rhizobium meliloti

Q92TC1
P23526

147
ASLLDEGTAAAEA

Streptomyces avermitilis,

Q827D7, Q9AK84,
P23378

Streptomyces coelicolor,

B1W4G3

Streptomyces griseus

148
ASLVHDDVIDDA

Bacillus subtilis

P31114
Q5T2R2

149
ATDIAARGLD

Bacillus subtilis

O34750
Q13206

150
ATDPDADRL

Bacillus subtilis

P18159
Q6PCE3

151
ATDVAARGLDI

Staphylococcus aureus,

Q6GEZ3, Q7A0D2,
Q9GZR7

Staphylococcus aureus,

Q6G7M9, Q5HEB9,

Staphylococcus aureus,

Q7A4G0, Q995H6,

Staphylococcus aureus,

Q2FF45, Q2FWH5,

Staphylococcus aureus,

Q2YUH3, Q8CRP6,

Staphylococcus aureus,

Q4L7W0, Q5HME0,

Staphylococcus aureus,

Q49Z29

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus saprophyticus

152
ATIAFGMGI

Haemophilus influenzae

P71359
P54132

153
ATINYPFEKGP

Rhizobium etli, Rhizobium

Q2K954, Q1MIK6,
O00217

leguminosarum, Rhizobium

B5ZYM2

leguminosarum

154
ATIQVYEETSG

Clostridium tetani

Q891P1
P38606

155
ATPKGYEPDA

Campylobacter curvus

A7GZL8
P00480

156
ATSGDTGSA

Pseudomonas aeruginosa

P29363
Q81Y07

157
ATVKGDVHDIGKN

Haemophilus influenzae

Q57195
Q99707

IV

158
ATWQKLLD

Neisseria meningitidis

Q9JTZ5
Q9H0R6

159
ATWCGPCKMI

Staphylococcus aureus,

Q6GA69, Q6GHU0,
P10599

Staphylococcus aureus,

P0A0K5, P0A0K6,

Staphylococcus aureus,

P99122, P0A0K4,

Staphylococcus aureus,

Q5HGT9, Q2YXD0,

Staphylococcus aureus,

Q2FZD2, Q2FHT6,

Staphylococcus aureus,

Q8CPL5, Q5HQ29,

Staphylococcus aureus,

Q49WR2, Q4L5F0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus saprophyticus,

Staphylococcus haemolyticus

160
AVDTTGAGD

Klebsiella pneumoniae

P26420
Q9H477

161
AVGIDLGTT

Bifidobacterium longum,

Q8G6W1, B3DNP9,
P11142

Bifidobacterium longum,

B8DT62

Bifidobacterium animalis

162
AVGKIVMEAAAK

Bacillus subtilis

P39616
P51648

163
AVGQGALGVE

Clostridium acetobutylicum

Q97MU4
P08397

164
AVGSDADIV

Rhizobium radiobacter

Q44184
Q14117

165
AVIHFAGLKAVGE

Klebsiella pneumoniae

P45602
Q14376

SV

166
AVITVPAYF

Corynebacterium efficiens,

Q8FM78, C3PJM6,
P0DMV9

Corynebacterium aurimucosum,

B0S1F8, Q03FR7

Finegoldia magna, Pediococcus

ntosaceus

167
AVITVPAYFND

Bacillus cytotoxicus, Bacillus cereus,

A7GT08, Q730M1,
P0DMV9

Bacillus cereus, Bacillus cereus,

B9IY81, B7HPL3,

Bacillus thuringiensis, Bacillus cereus,

Q6HDK7, Q634M7,

Bacillus cereus, Bacillus cereus,

Q818E9, B7HCU0,

Bacillus anthracis, Bacillus cereus,

C3L5R7, C1ESK8,

Bacillus anthracis, Bacillus

Q81L52, A0RIT3,

thuringiensis, Bacillus cereus, Bacillus

B7JN39, C3P8M0,

anthracis, Bacillus cereus, Bacillus

B7IYG7, A9VHU1,

weihenstephanensis, Bacillus

P05646, A8FFD2,

megaterium, Bacillus pumilus,

Q4JXX6, Q826F6

Corynebacterium jeikeium,

Streptomyces avermitilis

168
AVITVPAYFNDSQ

Campylobacter hominis

A7I2D4
P17066

R

169
AVITVPAYFNDSQ

Lactobacillus casei, Lactobacillus

Q038N3, B3WEQ7
P0DMV9

RQATKDAG

casei

170
AWSLLDNFEW

Paenibacillus polymyxa

P22073
Q9H227

171
AWTTTPWTLP

Clostridium kluyveri

A5N3P1
P41252

172
AWTTTPWTLPSN

Bacteroides fragilis, Bacteroides

Q64U07, Q5LCU8,
P41252

fragilis, Bacteroides thetaiotaomicron,

Q8A9K9, A0Q3B0,

Clostridium novyi, Clostridium tetani,

Q899C3, Q8XHE4,

Clostridium perfringens, Clostridium

Q97E50, Q7MUD3

acetobutylicum, Porphyromonas

gingivalis

173
AWTTTPWTLPSNL

Corynebacterium efficiens,

Q8FNV0, Q8NNP0
P41252

A

Corynebacterium glutamicum

174
AYEIIKLKG

Lactobacillus casei

P00343
P07864

175
AYEPVWAIG

Pseudomonas stutzeri

A4VPP4
P60174

176
AYEPVWAIGTG

Bifidobacterium longum,

B3DRW0, Q8G6D5,
P60174

Bifidobacterium longum,

A1A1N2, B0KHY2,

Bifidobacterium adolescentis,

Q88DV4, A5W991,

Pseudomonas putida, Pseudomonas

Q3KI88, Q1IF47,

putida, Pseudomonas putida,

Q4KIF9, A6VCK5,

Pseudomonas fluorescens,

B1J266, B7V1G0,

Pseudomonas entomophila,

Q9HV51, Q02FS4,

Pseudomonas fluorescens,

Q87WQ1, Q48E73,

Pseudomonas aeruginosa,

P95576, A4XYE4,

Pseudomonas putida, Pseudomonas

Q92QA1, Q98ME7,

aeruginosa, Pseudomonas

B4SQT8, B2FNY1

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas syringae,

Pseudomonas savastanoi,

Pseudomonas syringae,

Pseudomonas mendocina, Rhizobium

meliloti, Rhizobium loti,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

177
AYEPVWAIGTGK

Corynebacterium glutamicum,

A4QEG0, Q8FT67,
P60174

Corynebacterium efficiens,

P19583, Q6NH37,

Corynebacterium glutamicum,

B8DJI3, A4WG77,

Corynebacterium diphtheriae,

Q9Z6B9, B7NFL6,

Desulfovibrio vulgaris, Enterobacter

B7LVC6, P0A860,

sp., Enterobacter cloacae,
B7M6X0, B6I4R2,

Escherichia coli, Escherichia

A7ZUD3, Q1R3Z9,

fergusonii, Escherichia coli,

Q0TAE5, A8A724,

Escherichia coli, Escherichia coli,

B1LNM2, B1X1385,

Escherichia coli, Escherichia coli,

P0A859, P0A858,

Escherichia coli, Escherichia coli,

B1IVG0, A1AI95,

Escherichia coli, Escherichia coli,

B5YZ57, B7NU88,

Escherichia coli, Escherichia coli,

B7MI51, B5EF41,

Escherichia coli, Escherichia coli,

Q7X222, Q9JW31,

Escherichia coli, Escherichia coli,

Q9JXT8, Q9Z520,

Escherichia coli, Geobacter

Q829W1

bemidjiensis, Klebsiella pneumoniae,

Neisseria meningitidis, Neisseria

meningitidis, Streptomyces coelicolor,

Streptomyces avermitilis

178
AYEPVWAIGTGKT

Geobacter lovleyi

B3E9Q8
P60174

A

179
AYEPVWAIGTGKT

Geobacter uraniireducens, Ralstonia

A5G381, Q8XXP9
P60174

AT

solanacearum

180
AYEPVWAIGTGKT

Fusobacterium nucleatum, Uncultured

Q8RDX7, B1GZW3
P60174

ATP

termite

181
AYEVLSDPQ

Clostridium thermocellum,

A3DF24, Q835R5,
Q9NVH1

Enterococcus faecalis, Geobacter

Q74H58, B4F2V6,

sulfurreducens, Proteus mirabilis,

Q9RDD7, Q82BY4,

Streptomyces coelicolor,

O52164

Streptomyces avermitilis,

Streptomyces albus

182
AYNADFDGD

Aeromonas salmonicida, Aeromonas

A4SHV0, A0KQA4,
O95602

hydrophila, Akkermansia muciniphila,

B2UQY1, B2GDX6,

Lactobacillus fermentum,

Q1WVA4, A5VLL3,

Lactobacillus salivarius, Lactobacillus

B2G8Y5, Q88XZ2,

reuteri, Lactobacillus reuteri,

Q03PV0, A8F977,

Lactobacillus plantarum, Lactobacillus

A8YXJ9, A7ZON0,

brevis, Bacillus pumilus, Lactobacillus

Q5WLR9, A9VP70,

helveticus, Bacillus methylotrophicus,

Q5FM96, B3WAM7,

Bacillus clausii, Bacillus

P77819, Q034X1,

weihenstephanensis, Lactobacillus

P37871, A7GK13,

acidophilus, Lactobacillus casei,

Q9Z9M1, Q73FA3,

Bacillus anthracis, Lactobacillus

Q63H97, Q6HPR5,

casei, Bacillus subtilis, Bacillus

A0R8H3, Q81J47,

cytotoxicus, Bacillus halodurans,

Q38UQ3, Q65PB4,

Bacillus cereus, Bacillus cereus,

Q046D1, Q74L94,

Bacillus thuringiensis, Bacillus

Q04C21, Q1GBM4,

thuringiensis, Bacillus cereus,

Q250N9, A8AKT8,

Lactobacillus sakei, Bacillus

A3DIZ5, B1IGG1,

licheniformis, Lactobacillus gasseri,

A5I7L3, A7FZ76,

Lactobacillus johnsonii, Lactobacillus

B1KSN2, Q18CF3,

delbrueckii, Lactobacillus delbrueckii,

A7GJ81, A5N4P0,

Desulfitobacterium hafniense,

Q890N5, A0PXT9,

Citrobacter koseri, Clostridium

Q97EH0, A6LPQ5,

thermocellum, Clostridium botulinum,

B2TIG9, B2UYA4,

Clostridium botulinum, Clostridium

A4W5A8, Q82Z41,

botulinum, Clostridium botulinum,

Q0TA77, B1IU0Q,

ptoclostridium difficile, Clostridium

P0A8T7, A8A787,

botulinum, Clostridium kluyveri,

P0A8T8, B1XBZ0,

Clostridium tetani, Clostridium novyi,

A7ZUK2, B1LNU0,

Clostridium acetobutylicum,

Q1R5V4, A1AIG0,

Clostridium beijerinckii, Clostridium

Q8FB83, B0S2E5,

botulinum, Clostridium botulinum,

A6TGP1, P94892,

Enterobacter sp., Enterococcus
P94899, B1MWV7,

faecalis, Escherichia coli, Escherichia

P77879, Q724E9,

coli, Escherichia coli, Escherichia coli,

Q8YA96, A0AF64,

Escherichia coli, Escherichia coli,

P77882, P77917,

Escherichia coli, Escherichia coli,

Q03EB0, Q02T86,

Escherichia coli, Escherichia coli,

Q9HWC9, A6UZI2,

Escherichia coli, Finegoldia magna,

A4VHM4, A4XZ96,

Klebsiella pneumoniae, Leuconostoc

C3K2Y2, P0C1T4,

mesenteroides, Leuconostoc

P60286, Q6GBU4,

pseudomesenteroides, Leuconostoc

P60285, P60284,

citreum, Listeria innocua, Listeria

Q2G0N5, Q5HID2,

monocytogenes, Listeria

Q6GJC5, Q2YSB8,

monocytogenes, Listeria welshimeri,

Q2FJ97, Q4L3K4,

Listeria grayi, Pediococcus

Q8C083, Q5HRK9,

acidilactici, Pediococcus ntosaceus,

Q49V53, Q8DS47,

Pseudomonas aeruginosa,

C0M7R5, B8ZNW6,

Pseudomonas aeruginosa,

Q04IK7, Q8DNF1,

Pseudomonas aeruginosa,

A3CKD4, C1CMQ7,

Pseudomonas stutzeri, Pseudomonas

B5E2F2, C1CTL3,

mendocina, Pseudomonas

C1CGP3, B2IM39,

fluorescens, Staphylococcus aureus,

Q97N08, B1I8R3,

Staphylococcus aureus,

C1CA05, A8AZI2,

Staphylococcus aureus,

A4VSK3, A4VYU4,

Staphylococcus aureus,

Q8E238, Q8E7J7,

Staphylococcus aureus,

Q3K3L1, C0MEE4,

Staphylococcus aureus,

P0C0E0, Q48VR0,

Staphylococcus aureus,

A2RC52, Q5XE96,

Staphylococcus aureus,

P0DF33, Q1J8X0,

Staphylococcus aureus,

Q8P2Y2, Q1JJ22,

Staphylococcus aureus,

Q1JNX6, Q1JE19,

Staphylococcus haemolyticus,

P0DF32, B9DSZ6,

Staphylococcus epidermidis,

Q5M2F6, Q5LXV4,

Staphylococcus epidermidis,

Q03IK3, P96177,

Staphylococcus saprophyticus,

P96178

Streptococcus mutans, Streptococcus

equi, Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus sanguinis,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus gordonii,

Streptococcus suis, Streptococcus

suis, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus equi, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus uberis, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus

thermophilus, Weissella hellenica,

Weissella paramesenteroides

183
AYSGGLDTS

Uncultured termite

B1H0L3
P00966

184
CAAPGGKTTHI

Haemophilus ducreyi, Haemophilus

Q7VKC4, P44788
Q8TEA1

influenzae

185
CEAHLGHVF

Acinetobacter baumannii,

B2HYT2, A3M4Q3,
Q9Y3D2

Acinetobacter baumannii,

B7I415, B0VC45,

Acinetobacter baumannii,

B7H3X2, B0VR86

Acinetobacter baumannii,

Acinetobacter baumannii,

Acinetobacter baumannii

186
CEHHLVPFVG

Streptomyces avermitilis

Q82EE8
P30793

187
CETDFVSRN

Desulfovibrio vulgaris, Desulfovibrio

A1VFA9, Q72DQ6
P43897

vulgaris

188
CGNTVVVKP

Pseudomonas sp., Pseudomonas
P19059, P86808
P00352

putida

189
CGSGVTACH

Pseudomonas aeruginosa

Q9I452
P25325

190
CIFEYVYFARPDS

Haemophilus influenzae

P43854
Q06203

191
CIGEKLDEREAG

Desulfovibrio vulgaris, Desulfovibrio

Q72BF9, A1VDB2
P60174

vulgaris

192
CIRAGGKHNDL

Helicobacter hepaticus

Q7VHV4
P49588

193
CIRAGGKHNDLD

Campylobacter fetus, Campylobacter

A0RPR0, A8FKT2,
P49588

jejuni, Campylobacter jejuni,

Q9PI05, Q5HVQ7,

Campylobacter jejuni, Campylobacter

A7ZE62, A7H4N3,

concisus, Campylobacter jejuni,

A7GZA4, A7I206

Campylobacter curvus,

Campylobacter hominis

194
CLLTPGHTAG

Bacillus subtilis

O34769
Q6P1I5

195
CLNVGCIPSK

Corynebacterium glutamicum

Q8NTE1
P09622

196
CLNVGCIPSKALL

Escherichia coli, Escherichia coli,

P0A9P1, P0A9P0,
P09622

Escherichia coli, Haemophilus

P0A9P2, P43784

influenzae

197
CLSVNDAFV

Rhizobium sp., Rhizobium etli
Q53212, O69777
P30044

198
CNALETLLIH

Campylobacter jejuni, Campylobacter

A1VYR7, P53000,
P54886

jejuni, Geobacter lovleyi, Geobacter

B3E3M7, A5G906,

uraniireducens, Geobacter

Q39QR2, B9M0D6,

metallireducens, Geobacter daltonii,

C6E7L9, B5EEI4

Geobacter sp., Geobacter

bemidjiensis

199
CNAYTELNDP

Clostridium tetani

Q899G7
Q15046

200
CNRLRITADG

Lactobacillus plantarum, Lactobacillus

Q88WY1, B2GCN4
Q9NZB8

fermentum

201
CPVDAIVEG

Clostridium sp.
P00197
O00217

202
CPWGKGRPGWH

Clostridium novyi

A0PXS5
P49589

203
CRMCLVEIE

Rhizobium meliloti

P56914
P28331

204
DADLINAGKET

Bacillus subtilis, Helicobacter pylori,

P42316, P56007,
P55809

Helicobacter pylori

Q9ZLE4

205
DAFGLPAEN

Clostridium perfringens, Clostridium

Q8XML8, Q0SV78,
Q15031

perfringens, Clostridium perfringens,

Q0TTD0, A0PYK3,

Clostridium novyi, Clostridium

A5N399, A7G9T9

kluyveri, Clostridium botulinum

206
DAFGTAHRA

Acinetobacter baumannii,

B2HZB6, B71501,
P07205

Acinetobacter baumannii,

B0VD03, B7H3N8,

Acinetobacter baumannii,

B0VMX3, A3M4X6,

Acinetobacter baumannii,

Q6FB08, A0KGD3,

Acinetobacter baumannii,

A4SRF1, A4XPG4,

Acinetobacter baumannii,

B7V4D9, Q9I5Y4,

Acinetobacter baylyi, Aeromonas

Q02TL3, A6UZ15,

hydrophila, Aeromonas salmonicida,

C3K3F1, Q3K5F2,

Pseudomonas mendocina,

Q4K4J1, Q113Y0,

Pseudomonas aeruginosa,

B1J302, B0KLY7,

Pseudomonas aeruginosa,

Q88D64, A5W9Z6,

Pseudomonas aeruginosa,

B2FSF3, B4STV2

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas entomophila,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas putida,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

207
DAGKTTTTERILYY

Enterococcus faecalis, Streptococcus

Q839G9, B5XJR1,
Q969S9

pyogenes, Streptococcus uberis,

B9DVS2, P0DA85,

Streptococcus pyogenes,

Q48VB6, Q1J8I4,

Streptococcus pyogenes,

Q1JIM6, Q1JNH7,

Streptococcus pyogenes,

P69948, Q5XDW4,

Streptococcus pyogenes,

P0DA84, P69946,

Streptococcus pyogenes,

C0MF25, C0M937,

Streptococcus pyogenes,

B4U0V9, A2RCI2

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus equi, Streptococcus

equi, Streptococcus equi,

Streptococcus pyogenes

208
DAIVNAANS

Ralstonia solanacearum,

Q8Y2K1, Q8NYB7,
Q9B069

Staphylococcus aureus,

Q6GCE6, Q6GJZ1,

Staphylococcus aureus,

P67343, P67344,

Staphylococcus aureus,

Q5HIW9

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

209
DAIVNAANSSLLG

Streptomyces coelicolor

Q9ZBG3
Q9B069

GGGVDG

210
DAKINFDDNA

Geobacter sulfurreducens,

Q74EA5, Q4L5U8,
Q96199

Staphylococcus haemolyticus,

B9DPG0, Q6GHJ0,

Staphylococcus carnosus,

P66872, Q6G9W8,

Staphylococcus aureus,

A8Z355, Q5HGI7,

Staphylococcus aureus,

P99071, P66871,

Staphylococcus aureus,

A6QGE5, A5ISD0,

Staphylococcus aureus,

Q2FZ37, Q2FHJ3,

Staphylococcus aureus,

A6U164, A7X1L8,

Staphylococcus aureus,

Q2YXM1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

211
DALSSMANI

Haemophilus influenzae

P43842
Q13423

212
DALSSMANIAGY

Escherichia coli

P07001
Q13423

213
DAPVSGGVG

Pseudomonas aeruginosa

P28811
P31937

214
DAQRQATKD

Clostridium cellulolyticum

B8I305
P11021

215
DAQRQATKDAG

ptoclostridium difficile,

Q182E8, C4LGV8
P11021

Corynebacterium kropnstedtii

216
DAQRQATKDAGTI

Desulfitobacterium hafniense

B8FUN4
P11021

AGL

217
DAVGMSTVPEVIV

Bacillus subtilis

P46354
P00491

A

218
DCPGHADYVKNMI

Helicobacter pylori

Q9ZK19
P49411

TG

219
DDITHPIPDLTG

Geobacter uraniireducens

A5GCR3
P15313

220
DDLLATGGT

Lactobacillus plantarum, Lactobacillus

Q88VH0, Q038P1,
P07741

Qcasei, Lactobacillus brevis,

Q3QP8, Q38W53,

Lactobacillus sakei, Lactobacillus

Q1WT53, Q5WHQ1,

salivarius, Bacillus clausii, Bacillus

Q9KDH2, A8FFQ0,

halodurans, Bacillus pumilus, Bacillus

A7GT90, Q65G08,

cytotoxicus, Bacillus licheniformis,

Q34443, B7HE42,

Bacillus subtilis, Bacillus cereus,

Q634D6, Q817X3,

Bacillus cereus, Bacillus cereus,

B711S0, Q730C4,

Bacillus cereus, Bacillus cereus,

Q81LI1, Q6HDB8,

Bacillus anthracis, Bacillus

B7HQG7, A0RJ16,

thuringiensis, Bacillus cereus, Bacillus

C3L613, C3P995,

thuringiensis, Bacillus anthracis,

B9IYY2, B7JPZ4,

Bacillus anthracis, Bacillus cereus,

Q892A7, C4XU70,

Bacillus cereus, Clostridium tetani,

Q834G6, A5UBP3,

Desulfovibrio maeticus, Enterococcus

P43856, Q4QJV7,

faecalis, Haemophilus influenzae,

A5UF74, Q0I3U5,

Haemophilus influenzae,

O25296, Q1CTV4,

Haemophilus influenzae,

B2UTQ6, B6JLF4,

Haemophilus influenzae,

B5Z6U3, Q17W08,

Haemophilus somnus, Helicobacter

A0AIX3, C1KVH1,

pylori, Helicobacter pylori,

Q71ZE6, B8DHM4,

Helicobacter pylori, Helicobacter

P0A2X6, P0A2X5,

pylori, Helicobacter pylori,

Q03F39

Helicobacter acinonychis, Listeria

welshimeri, Listeria monocytogenes,

Listeria monocytogenes, Listeria

monocytogenes, Listeria innocua,

Listeria monocytogenes, Pediococcus

ntosaceus

221
DDLLATGGTM

Bacteroides fragilis, Bacteroides

Q5LIY6, Q650H6,
P07741

fragilis, Geobacter lovleyi, Geobacter

B3E683, A5G4S5,

uraniireducens, Geobacter daltonii,

B9M4Z1, B5EHF2,

Geobacter bemidjiensis, Geobacter

C6E585

sp.

222
DDNEETIKKRL

Bacteroides thetaiotaomicron,

Q89ZJ0, A6L0Z9,
P00568

Bacteroides vulgatus, Bacteroides

Q64XA6, Q5LGH0

fragilis, Bacteroides fragilis

223
DEELKKAYR

Stenotrophomonas maltophilia

B4SSQ7
Q9H819

224
DEIKKAYRK

Acinetobacter baumannii,

B0VA24, A3MA88,
O75953

Acinetobacter baumannii,

B0VQ00, B212G6,

Acinetobacter baumannii,

B7I2B2, B7GV08,

Acinetobacter baumannii,

Q6F6R1, A7Z6W0,

Acinetobacter baumannii,

A8FFD1, Q65H55,

Acinetobacter baumannii,

P17631, Q88VM1,

Acinetobacter baylyi, Bacillus

Q03QU2, Q8G6C6,

methylotrophicus, Bacillus pumilus,

A0Q1R3, B8DE39,

Bacillus licheniformis, Bacillus subtilis,

Q92BN9, P0DJM1,

Lactobacillus plantarum, Lactobacillus

G2K045, Q71ZJ8,

brevis, Bifidobacterium longum,

C1KVB9, A0AIS3,

Clostridium novyi, Listeria

A1KR91, P63969,

monocytogenes, Listeria innocua,

P63968, A9LZV9,

Listeria monocytogenes, Listeria

Q5F5M1, Q8XW41,

monocytogenes, Listeria

B2UBP2, Q2YT48,

monocytogenes, Listeria

P63972, A8Z4B8,

monocytogenes, Listeria welshimeri,

Q6G8Y8, P63971,

Neisseria meningitidis, Neisseria

P63970, A6QHC2,

meningitidis, Neisseria meningitidis,

Q5HFI1, A5ITA7,

Neisseria meningitidis, Neisseria

Q2FXZ3, Q2FGE4,

gonorrhoeae, Ralstonia

A6U251, A7X2Y0,

solanacearum, Ralstonia pickettii,

Q6GGC1, P45555,

Staphylococcus aureus,

Q8CVVT2, P95830

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus pneumoniae,

Streptococcus pneumoniae

225
DEIKKAYRKM

Streptococcus uberis

B9DVF2
O75953

226
DELGRGTAT

Leuconostoc citreum, Leuconostoc

B1N025, Q03VV4
P52701

mesenteroides

227
DELGRGTSTYDG

Bacteroides fragilis, Bacteroides

Q64MG7, Q5L7B7,
P43246

fragilis, Bacteroides thetaiotaomicron,

Q8A334, A6KZM1,

Bacteroides vulgatus, Porphyromonas

Q7MXR7

gingivalis

228
DEPTNHLDME

Escherichia coli, Escherichia coli,

P0A9U3, P0A9U4,
Q9NUQ8

Escherichia coli

P0A9U5

229
DEVQTGFGR

Bacillus pseudofirmus

P30268
Q9BYV1

230
DEYVGLPRDH

Corynebacterium kropnstedtii

C4LL80
P46926

231
DFALWKAAKP

Corynebacterium glutamicum,

A4QH41, Q6NFC3,
Q9HA77

Corynebacterium diphtheriae,

Q8NMD7, C6B523

Corynebacterium glutamicum,

Desulfovibrio salexigens

232
DFALWKASKP

Fusobacterium nucleatum

Q8RIK9
P49589

233
DFALWKASKPGE

Desulfovibrio maeticus

C4XSW5
P49589

P

234
DFIKTSTGK

Aeromonas salmonicida, Aeromonas

A4SRU4, A0KPE4,
Q9Y315

hydrophila, Edwardsiella ictaluri,

C5BHJ2, A4W698,

Enterobacter sp., Escherichia coli,
B1LEI6, B7LXU3,

Escherichia coli, Escherichia

B7LNS1, B6I6M8,

fergusonii, Escherichia coli,

B1IS38, A8A8B0,

Escherichia coli, Escherichia coli,

B7NW61, B7N2V7,

Escherichia coli, Escherichia coli,

B5Z4R3, Q8XB36,

Escherichia coli, Escherichia coli,

B7LEM7, A7ZVS4,

Escherichia coli, Escherichia coli,

B7UR09, P0A6L0,

Escherichia coli, Escherichia coli,

B7NH49, P0A6L1,

Escherichia coli, Escherichia coli,

B1XFJ1, B7MNI8,

Escherichia coli, Escherichia coli,

Q0T8T2, C4ZT63,

Escherichia coli, Escherichia coli,

A1AJU8, B8F671,

Escherichia coli, Haemophilus

Q7VMS9, B5Y277,

parasuis, Haemophilus ducreyi,

B4EWA4

Klebsiella pneumoniae, Proteus

mirabilis

235
DFSGGWRMR

Escherichia coli, Escherichia coli

P63390, P63389
Q9UG63

236
DFSSPNIAK

Fusobacterium nucleatum

Q8RG14
P54136

237
DFTFVCPTE

Bacillus sp., Escherichia coli,
P26830, P0AE08,
Q06830

Escherichia coli, Escherichia coli

P0AE09, P0AE10

238
DFTFVCPTEI

Bacillus subtilis

Q34564
Q06830

239
DFTFVCPTEIIAF

Helicobacter pylori, Helicobacter

P56876, P21762
Q06830

pylori

240
DGAGKTSVL

Streptococcus uberis

B9DTV7
Q6T311

241
DGEAGGITQ

Lactobacillus brevis

Q03QT5
Q60841

242
DGGQWDMLV

Listeria monocytogenes, Listeria

Q69192, Q928V0
Q13867

innocua

243
DGHIAFNEP

Corynebacterium diphtheriae

Q6NJ91
P46926

244
DGHTASLFP

Haemophilus influenzae, Helicobacter

Q57039, O25730,
Q95479

pylori, Helicobacter pylori,

Q9ZKB1, Q9EV79,

Pseudomonas putida, Pseudomonas

Q9X2N2

aeruginosa

245
DGILVPGGFG

Desulfovibrio desulfuricans

B8IZF5
Q9NRF8

246
DGKLYGRGA

Ralstonia solanacearum

Q8XZK5
Q96KN2

247
DGLGFGDNTKAA

Desulfitobacterium hafniense

Q24VA4
P21695

248
DGPLDMRMD

Acinetobacter baumannii,

B0VPF9, B0V8N7,
A6NJ78

Acinetobacter baumannii,

A3M9K5, B2I0K7,

Acinetobacter baumannii,

B7GVN1, B7IAX1,

Acinetobacter baumannii,

Q6F7D1, A8ALL4,

Acinetobacter baumannii,

Q313R1, B8DP86,

Acinetobacter baumannii,

A1VBE0, P62470,

Acinetobacter baylyi, Citrobacter

C5B9E8, A4W6I5,

koseri, Desulfovibrio alaskensis,

B7LWH0, B1LG19,

Desulfovibrio vulgaris, Desulfovibrio

Q1RGB3, B6HZ59,

vulgaris, Desulfovibrio vulgaris,

A7ZW34, B7N7V5,

Edwardsiella ictaluri, Enterobacter

P60390, A1A7C7,

sp., Escherichia fergusonii,
B1IR96, Q0TLQ7,

Escherichia coli, Escherichia coli,

C5W331, B1XC59,

Escherichia coli, Escherichia coli,

C6UM45, C4ZQ04,

Escherichia coli, Escherichia coli,

B7M125, B5YZB8,

Escherichia coli, Escherichia coli,

P60391, B7LFV2,

Escherichia coli, Escherichia coli,

B7MAK5, A7ZHH3,

Escherichia coli, Escherichia coli,

B7NHI8, Q8FL68,

Escherichia coli, Escherichia coli,

B7MNU1, B7UID2,

Escherichia coli, Escherichia coli,

B3E3Z0, Q7VP62,

Escherichia coli, Escherichia coli,

B8F3A8, A6T4M5,

Escherichia coli, Escherichia coli,

B5Y1V5, B4F119,

Escherichia coli, Escherichia coli,

Q87WX7, C3KCS2,

Escherichia coli, Geobacter lovleyi,

Q4ZNY2, Q3K736,

Haemophilus ducreyi, Haemophilus

Q48EF0, Q4K6I5,

parasuis, Klebsiella pneumoniae,

A4VIH0, Q8XVH9,

Klebsiella pneumoniae, Proteus

C6BEJ1, B2UCY5

mirabilis, Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas savastanoi,

Pseudomonas fluorescens,

Pseudomonas stutzeri, Ralstonia

solanacearum, Ralstonia pickettii,

Ralstonia pickettii

249
DGPMPQTREH

Lactobacillus brevis, Desulfovibrio

Q03QN5, B8DLL9,
P49411

vulgaris, Desulfovibrio vulgaris,

A1VAK4, Q727D5,

Desulfovibrio vulgaris, Desulfovibrio

B8J1A0, Q30X13

desulfuricans, Desulfovibrio

alaskensis

250
DGTKFDSSLDR

Neisseria meningitidis

P0A0W3
Q02790

251
DGVGTKLKIA

Rhizobium leguminosarum

Q9XAT2
P22102

252
DGWDSEPFT

Campylobacter concisus

A7ZFC1
Q96KP4

253
DHGKSTLADR

Acinetobacter baumannii,

B0VCT7, A3M7P5,
Q8N442

Acinetobacter baumannii,

B2HWQ2, B71580,

Acinetobacter baumannii,

B7GYS7, B0VTM2,

Acinetobacter baumannii,

Q6F9B9, A7GT14,

Acinetobacter baumannii,

Q9KD76, Q5WHG5,

Acinetobacter baumannii,

P37949, A8FFD6,

Acinetobacter baylyi, Bacillus

Q730L6, A7Z6W5,

cytotoxicus, Bacillus halodurans,

Q65H50, B7HCU5,

Bacillus clausii, Bacillus subtilis,

B7IYH2, C3L5S2,

Bacillus pumilus, Bacillus cereus,

B7HPL8, B7JNV1,

Bacillus methylotrophicus, Bacillus

Q81LR7, C3P8M5,

licheniformis, Bacillus cereus, Bacillus

Q6HDK2, Q634M2,

cereus, Bacillus anthracis, Bacillus

C1ESL3, A0RIT7,

cereus, Bacillus cereus, Bacillus

Q818E4, B9IY86,

anthracis, Bacillus anthracis, Bacillus

A9VHU6, Q38W39,

thuringiensis, Bacillus cereus, Bacillus

Q038N6, B3WEQ5,

cereus, Bacillus thuringiensis, Bacillus

C4Z9E3, C4Z541,

cereus, Bacillus cereus, Bacillus

Q6A9B2, A0RQX4,

weihenstephanensis, Lactobacillus

A1W018, Q9PNR1,

sakei, Lactobacillus casei,

A8FM79, Q5HU70,

Lactobacillus casei, Eubacterium

A7H311, B9KD01,

rectale, Eubacterium eligens,

A9KKU4, Q72E76,

Propionibacterium acnes,

B8DIZ5, C6BST2,

Campylobacter fetus, Campylobacter

Q30XI4, B8J444,

jejuni, Campylobacter jejuni,

Q831Z0, B2GHU9,

Campylobacter jejuni, Campylobacter

Q8Y742, B8DE32,

jejuni, Campylobacter jejuni,

C1KVC6, Q71ZJ1,

Campylobacter lari, Clostridium

Q92BN4, A0AIS8,

phytofermentans, Desulfovibrio

C5CCD4, Q5F9P9,

vulgaris, Desulfovibrio vulgaris,

B4RK41, A1KT27,

Desulfovibrio salexigens,

Q9K055, Q9JV65,

Desulfovibrio alaskensis,

A9M3J8, A4XSC1,

Desulfovibrio desulfuricans,

Q87XF8, Q1I5V6,

Enterococcus faecalis, Kocuria

C3K6G8, Q4KHT3,

rhizophila, Listeria monocytogenes,

A5W8F4, Q88MY7,

Listeria monocytogenes, Listeria

B0KV29, Q48EV0,

monocytogenes, Listeria

Q4ZPD8, B1J4D8,

monocytogenes, Listeria innocua,

Q3KHM1, A4VIX2,

Listeria welshimeri, Micrococcus

Q9I5G8, Q02HR9,

luteus, Neisseria gonorrhoeae,

B7UYX5, A6VAK9,

Neisseria gonorrhoeae, Neisseria

A8Z4C4, A6QHC7,

meningitidis, Neisseria meningitidis,

Q5HFH6, Q2FXY7,

Neisseria meningitidis, Neisseria

Q2FGD9, Q6G8Y3,

meningitidis, Pseudomonas

Q6GGB6, P65272,

mendocina, Pseudomonas syringae,

P65271, A5ITB2,

Pseudomonas entomophila,

Q2YT42, A7X2Y7,

Pseudomonas fluorescens,

A6U257, Q8NWA7,

Pseudomonas fluorescens,

Q4L6T4, Q5HNW2,

Pseudomonas putida, Pseudomonas

Q8CP13, B9DNK4,

putida, Pseudomonas putida,

Q49Y26, C1CKU6,

Pseudomonas savastanoi,

Q970K5, C1C7G9,

Pseudomonas syringae,

B5E4T8, B1ICO2,

Pseudomonas putida, Pseudomonas

A4VUL8, A4WOW0,

fluorescens, Pseudomonas stutzeri,

Q8DTF3, A8AWG3,

Pseudomonas aeruginosa,

C1CR98, Q8DPN5,

Pseudomonas aeruginosa,

B8Z069, Q04KB7,

Pseudomonas aeruginosa,

B9DSE0, Q5M008,

Pseudomonas aeruginosa,

Q03KW7, Q5M4M2,

Staphylococcus aureus,

B4U3G9, C0M8H9,

Staphylococcus aureus,

C1CEG3, P65274,

Staphylococcus aureus,

Q3K1F9, P65273,

Staphylococcus aureus,

C0MDV7, Q1JH37,

Staphylococcus aureus,

Q48TU0, Q1JLY8,

Staphylococcus aureus,

Q99ZV8, B5XLC6,

Staphylococcus aureus,

P0DC23, P0DC22,

Staphylococcus aureus,

Q1JC06, Q5XCD2,

Staphylococcus aureus,

Q1J6V6, Q82BZ3,

Staphylococcus aureus,

Q9RDC9, B1VY28

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus carnosus,

Staphylococcus saprophyticus,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus suis, Streptococcus

suis, Streptococcus mutans,

Streptococcus gordonii,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus uberis, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus equi,

Streptococcus equi, Streptococcus

pneumoniae, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus equi, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptomyces avermitilis,

Streptomyces coelicolor,

Streptomyces griseus

254
DHGKSTLADRL

Desulfitobacterium hafniense,

Q245R6, B8FUP2,
Q8N442

Desulfitobacterium hafniense,

A7I1F0, A7ZCJ3,

Campylobacter hominis,

A7GZW3, Q182F4,

Campylobacter concisus,

B0S1G2, Q7VJZ1,

Campylobacter curvus, ptoclostridium

A5VB59

difficile, Finegoldia magna,

Helicobacter hepaticus,

Sphingomonas wittichii

255
DHGKSTLADRLLE

Bacteroides vulgatus,

A6L744, A6LC18,
Q8N442

Parabacteroides distasonis,

Q8AA33, Q64T74,

Bacteroides thetaiotaomicron,

Q5LC85, Q97JJ6,

Bacteroides fragilis, Bacteroides

A0Q1R8, B8I3E6,

fragilis, Clostridium acetobutylicum,

A3DF29, Q892Q6,

Clostridium novyi, Clostridium

Q39U57, B5EB36,

cellulolyticum, Clostridium

A5G4G3, P60789,

thermocellum, Clostridium tetani,

C6DZ67, B9M4U5,

Geobacter metallireducens,

B3E9R0, B2RKK1,

Geobacter bemidjiensis, Geobacter

Q7MV56

uraniireducens, Geobacter

sulfurreducens, Geobacter sp.,

Geobacter daltonii, Geobacter lovleyi,

Porphyromonas gingivalis,

Porphyromonas gingivalis

256
DHPDAFDNEL

Clostridium botulinum, Clostridium

A7GGE1, B1IJ68,
Q9BZX2

botulinum, Clostridium botulinum,

C1FSX6, C3L140,

Clostridium botulinum, Clostridium

B1KXA7

botulinurn

257
DHYENPRNVGS

Escherichia coli, Escherichia coli,

P0ACD5, P0ACD4,
Q9H1K1

Escherichia coli

P0ACD6

258
DHYENPRNVGSL

Haemophilus influenzae

Q57074
Q9H1K1

DK

259
DIEMSFVDQ

Corynebacterium diphtheriae,

Q6NGZ4, Q49Y68,
Q6PI48

Staphylococcus saprophyticus,

Q2FXU5, P67016,

Staphylococcus aureus,

A8Z2F7, Q6G8T9,

Staphylococcus aureus,

P67015, A6QHH2,

Staphylococcus aureus,

P67014, Q5HFD3,

Staphylococcus aureus,

A5ITF4, Q2YT75,

Staphylococcus aureus,

Q2FG97, A7X344,

Staphylococcus aureus,

A6U298, Q6GG73,

Staphylococcus aureus,

Q4L6X5, Q8C599,

Staphylococcus aureus,

Q5HN52

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

260
DILVNNAGI

Bacillus subtilis, Bacillus subtilis,

P42317, P50842,
Q6IAN0

Haemophilus influenzae

P43713

261
DILVNNAGV

Rhizobium meliloti

O86034
P15428

262
DISPQAPTH

Escherichia coli, Escherichia coli

P0ACE7, P0ACE8
P49773

263
DIYSRLLRERI

Methylobacterium populi,

B1Z9C7, A9W5F5,
Q16740

Methylobacterium extorquens,

B7KNT0, B1LW28,

Methylobacterium extorquens,

B8IN26, Q1MK43,

Methylobacterium radiotolerans,

P58277, Q2KAB9

Methylobacterium nodulans,

Rhizobium leguminosarum,

Rhizobium meliloti, Rhizobium etli

264
DKAGGYGIQ

Parabacteroides distasonis,

A6L8E5, Q3KI22
O95671

Pseudomonas fluorescens

265
DKHSTGGVGD

Rhizobium loti

Q98GV5
P19971

266
DKPDTRFGM

Eubacterium rectale

C4ZI12
Q6PI48

267
DKPRYLMGVG

Acinetobacter baumannii, Aeromonas

B0VRA8, A0KJ20,
Q9BXR0

hydrophila, Aeromonas salmonicida,

A45P26, Q38YP9,

Lactobacillus sakei, Bacillus clausii,

Q5WHR2, A8AK48,

Citrobacter koseri, Desulfovibrio

A1VFP3, Q72E53,

vulgaris, Desulfovibrio vulgaris,

C5BCF7, A4W779,

Edwardsiella ictaluri, Enterobacter

B7LMI1, B7N8V8,

sp., Escherichia fergusonii,
B1J043, Q1RFD5,

Escherichia coli, Escherichia coli,

B1LJF4, B6HZK6,

Escherichia coli, Escherichia coli,

B7M3P5, P0A847,

Escherichia coli, Escherichia coli,

P0A848, B7L639,

Escherichia coli, Escherichia coli,

Q0TKN5, A7ZX57,

Escherichia coli, Escherichia coli,

A1A876, C4ZTG3,

Escherichia coli, Escherichia coli,

B7MD64, B1XEZ4,

Escherichia coli, Escherichia coli,

B5Z2W2, B7MPG7,

Escherichia coli, Escherichia coli,

B7NJ96, P0A849,

Escherichia coli, Escherichia coli,

A7ZIF8, B7UJM9,

Escherichia coli, Escherichia coli,

Q4QNU3, A5UG47,

Escherichia coli, Haemophilus

A5UAP3, P44594,

influenzae, Haemophilus influenzae,

Q0I4R8, B8F3W0,

Haemophilus influenzae,

Q7VLQ4, A6T5D8,

Haemophilus influenzae,

B5Y0Y6, B4EU13,

Haemophilus somnus, Haemophilus

Q88PL7, Q9HXH9,

parasuis, Haemophilus ducreyi,

B7UVU4, Q02RX7,

Klebsiella pneumoniae, Klebsiella

Q887B0, Q92PY4,

pneumoniae, Proteus mirabilis,

Q98M57, Q4L6Y4

Pseudomonas putida, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas syringae,

Rhizobium meliloti, Rhizobium loti,

Staphylococcus haemolyticus

268
DKTGTITHG

Ralstonia solanacearum

Q8XU11
P35670

269
DLAIDGADEVD

Staphylococcus haemolyticus

Q4L8J6
P49247

270
DLEFVQFHPT

Rhizobium loti, Streptomyces

Q98AV8, Q9X8N8
P31040

coelicolor

271
DLIIPRGSS

Bacteroides fragilis, Bacteroides

Q64Z29, Q5LI24,
P54886

fragilis, Bacteroides thetaiotaomicron,

Q8A1E8, A6LE74

Parabacteroides distasonis

272
DLIVSNPPY

Aeromonas hydrophila, Aeromonas

A0KPC4, A4SRS5,
Q9Y5R4

salmonicida, Fusobacterium

Q8R619, A5HY34,

nucleatum, Clostridium botulinum,

A4WDE6, Q74862,

Enterobacter sp., Geobacter
P45253, B8F678,

sulfurreducens, Haemophilus

B4F055

influenzae, Haemophilus parasuis,

Proteus mirabilis

273
DLIVSNPPYV

Neisseria meningitidis, Neisseria

Q9JTA1, Q9JYC0,
Q9Y5R4

meningitidis, Neisseria gonorrhoeae,

Q5F783, Q91347

Pseudomonas aeruginosa

274
DLKKAYRRLA

Pseudomonas fluorescens,

C3K274, Q1IF58
Q9NXW2

Pseudomonas entomophila

275
DLNRAGVGL

Uncultured termite

B1GZD2
O75879

276
DLPLNVSRE

Arcobacter butzleri, Methylobacterium

A8EV23, B0UN89,
P14625

sp., Geobacter uraniireducens,
A5GER7, Q17VU7,

Helicobacter acinonychis,

Q1CUU4, Q9ZMM2,

Helicobacter pylori, Helicobacter

Q7VFD7, B81U50,

pylori, Helicobacter hepaticus,

B1LZG0, Q2JZH2,

Methylobacterium nodulans,

P58477

Methylobacterium radiotolerans,

Rhizobium etli, Rhizobium meliloti

277
DLQEDKEAVF

Bifidobacterium longum,

B7GTN9, Q8G5F3,
P04424

Bifidobacterium longum,

B3DSY6

Bifidobacterium longum

278
DLRLNEPRYA

Pseudomonas aeruginosa

Q9HZP6
P38117

279
DLTDEEKQE

Bacillus licheniformis

Q65KJ6
Q969G3

280
DLTHNPEFT

Campylobacter hominis

A7I358
Q15046

281
DLTHNPEFTT

Campylobacter jejuni, Campylobacter

A8FKI8, A7H4X7,
Q15046

jejuni, Campylobacter jejuni,

Q5HW66, A1VYC1,

Campylobacter jejuni, Campylobacter

P41258

jejuni

282
DLTVPFARY

Propionibacterium acnes,

Q6A8J7, C5CCH4
P12081

Micrococcus luteus

283
DLVGNNTPIFF

Micrococcus luteus

P29422
P04040

284
DLVGNNTPIFFI

Escherichia coli

P21179
P04040

285
DNFWEMGDTGPC

Bacteroides fragilis, Bacteroides

Q64Y64, Q5LHE6,
P49588

GPCSEIH

fragilis, Bacteroides thetaiotaomicron,

Q8A0M6, A6LEZ8,

Parabacteroides distasonis,

A6L1L8, Q7MV54

Bacteroides vulgatus, Porphyromonas

gingivalis

286
DNHLILVDL

Clostridium perfringens, Clostridium

Q8XJ32, Q0TP32,
P34896

perfringens, Clostridium botulinum,

B2V398, Q0SRQ2,

Clostridium perfringens, Clostridium

B2TN52

botulinurn

287
DNHLILVDLRS

Bacillus subtilis

P39148
P34896

288
DPLDGSSNI

Methylobacterium radiotolerans,

B1LUU9, B1Z939,
P09467

Methylobacterium populi,

B7L270, A9W1C8

Methylobacterium extorquens,

Methylobacterium extorquens

289
DPLDGSSNID

Aeromonas hydrophila, Aeromonas

A0KJT2, A4SM33,
P09467

salmonicida, Citrobacter koseri,

A8AMG4, A4W5X6,

Enterobacter sp., Escherichia coli,
Q1R324, B1LRB5,

Escherichia coli, Escherichia coli,

P0A994, P0A993,

Escherichia coli, Escherichia coli,

B1ISX3, Q0T9F7,

Escherichia coli, Escherichia coli,

A1AJD7, A8A7Y7,

Escherichia coli, Escherichia coli,

B1XEL4, A7ZVB0,

Escherichia coli, Escherichia coli,

B5Z317, Q8XCF0,

Escherichia coli, Haemophilus

A5UCP1, P45292,

influenzae, Haemophilus influenzae,

Q7VN74, Q4QL80,

Haemophilus ducreyi, Haemophilus

Q0I4Y5, B5Y2X3,

influenzae, Haemophilus somnus,

A6THE3, B4F298,

Klebsiella pneumoniae, Klebsiella

Q9EXV4

pneumoniae, Proteus mirabilis,

Rhizobium meliloti

290
DPSIFTVLT

Pseudomonas syringae

Q4ZR64
Q93099

291
DPTLLFANAGMN

Geobacter metallireducens,

Q39Z77, P61701
P49588

QFK

Geobacter sulfurreducens

292
DQISDAVLD

Desulfovibrio alaskensis,

Q311V1, Q7VNG7,
P31153

Haemophilus ducreyi, Haemophilus

A5UIU0, A5UCT6,

influenzae, Haemophilus influenzae,

P43762, Q4QLC5,

Haemophilus influenzae,

Q0I559, B8F4B2,

Haemophilus influenzae,

Q7VFY5, Q9ZMN5,

Haemophilus somnus, Haemophilus

B6JPU7, B5Z9W8,

parasuis, Helicobacter hepaticus,

Q1CUW4, B2US27,

Helicobacter pylori, Helicobacter

P56460, Q17YQ7

pylori, Helicobacter pylori,

Helicobacter pylori, Helicobacter

pylori, Helicobacter pylori,

Helicobacter acinonychis

293
DQISDAVLDA

Citrobacter koseri, Edwardsiella

A8APG1, C5BAV4,
Q00266

ictaluri, Enterobacter sp., Escherichia
A4WE78, B7LPQ9,

fergusonii, Escherichia coli,

B1LDF1, B61780,

Escherichia coli, Escherichia coli,

B7N7J5, P0A817,

Escherichia coli, Escherichia coli,

B1IT65, P0A818,

Escherichia coli, Escherichia coli,

A8A481, Q0TDR0,

Escherichia coli, Escherichia coli,

B1XFA4, C5A0L1,

Escherichia coli, Escherichia coli,

B5YQD9, B7NI05,

Escherichia coli, Escherichia coli,

B7LYX2, P0A819,

Escherichia coli, Escherichia coli,

B7LFK4, B7UHY9,

Escherichia coli, Escherichia coli,

A7ZR64, A6TDV1,

Klebsiella pneumoniae, Klebsiella

B5XUA8, B4F1A5,

pneumoniae, Proteus mirabilis,

A4XPF8, Q48CH3,

Pseudomonas mendocina,

Q4ZMO1, Q88AK7,

Pseudomonas savastanoi,

A4VRE8, C3K3F5,

Pseudomonas syringae,

B1J2Z8, Q4K4I7,

Pseudomonas syringae,

Q3K5E8, A6UZ09,

Pseudomonas stutzeri, Pseudomonas

Q915Z0, Q02TL9,

fluorescens, Pseudomonas putida,

B7V4D3, Q88D60,

Pseudomonas fluorescens,

B0KLZ1, A5WA00,

Pseudomonas fluorescens,

Q1I3X6, B2FPC7,

Pseudomonas aeruginosa,

B4SK03

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas entomophila,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

294
DRILASRMG

Clostridium tetani

Q890Z2
Q01813

295
DRQPEFTQID

Lactobacillus casei, Lactobacillus

Q038S1, B3WEM2,
Q6PI48

casei, Lactobacillus plantarum,

Q88V08, Q38X136,

Lactobacillus sakei, Lactobacillus

Q74IX4, Q5FKI4,

johnsonii, Lactobacillus acidophilus,

B2G6X9, A5VJG4,

Lactobacillus reuteri, Lactobacillus

B2GBY7, Q64T01,

reuteri, Lactobacillus fermentum,

Q5LCK2, A6LBU6,

Bacteroides fragilis, Bacteroides

Q9PHM7, A8FL61,

fragilis, Parabacteroides distasonis,

A1VZ00, A8AFH5,

Campylobacter jejuni, Campylobacter

A9KIA6, A4WBM3,

jejuni, Campylobacter jejuni,

Q8XCI7, B5YR11,

Citrobacter koseri, Clostridium

P21889, A8A166,

phytofermentans, Enterobacter sp.,
C4ZQF0, B1XHD4,

Escherichia coli, Escherichia coli,

B7NS52, B6IBU5,

Escherichia coli, Escherichia coli,

B1LD05, B7NBL7,

Escherichia coli, Escherichia coli,

B1J0M2, B7M2F7,

Escherichia coli, Escherichia coli,

B7L7R9, A7ZMZ0,

Escherichia coli, Escherichia coli,

B7LPH8, B7USP3,

Escherichia coli, Escherichia coli,

Q1RAR8, Q8FGQ9,

Escherichia coli, Escherichia coli,

Q0TGW6, A1AC27,

Escherichia fergusonii, Escherichia

B7MVZ7, B7MBS5,

coli, Escherichia coli, Escherichia coli,

C6E3W7, B5EIV1,

Escherichia coli, Escherichia coli,

A5G3L5, Q74D56,

Escherichia coli, Escherichia coli,

B9M1C9, Q39VY3,

Geobacter sp., Geobacter
Q7VNF0, B8F789,

bemidjiensis, Geobacter

A5UAG7, A5UGD3,

uraniireducens, Geobacter

A6TB35, B5XQ00,

sulfurreducens, Geobacter daltonii,

B8DHM9, Q71ZF1,

Geobacter metallireducens,

C1KVG6, Q8Y709,

Haemophilus ducreyi, Haemophilus

Q92BJ4, A0AIW8,

parasuis, Haemophilus influenzae,

A9M257, B4RPA1,

Haemophilus influenzae, Klebsiella

A1KVG2, Q9JT23,

pneumoniae, Klebsiella pneumoniae,

Q9K0U5, Q03F52,

Listeria monocytogenes, Listeria

B4ETP3

monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Listeria innocua,

Listeria welshimeri, Neisseria

meningitidis, Neisseria gonorrhoeae,

Neisseria meningitidis, Neisseria

meningitidis, Neisseria meningitidis,

Pediococcus ntosaceus, Proteus

mirabilis

296
DRQPEFTQIDIE

Bacillus clausii, Bacillus halodurans,

Q5WHP3, Q9KDG1,
Q6PI48

Enterococcus faecalis, Pseudomonas

Q833I2, Q3K7V6,

fluorescens, Pseudomonas syringae,

Q4ZWL5, Q87Y31,

Pseudomonas syringae,

Q48FC1, C3JYT1

Pseudomonas savastanoi,

Pseudomonas fluorescens

297
DRQPEFTQIDIEM

Bacillus subtilis, Bacillus

O32038, A7Z750,
Q6PI48

SF

methylotrophicus, Bacillus

Q65GR4, Q5HVD1,

licheniformis, Campylobacter jejuni,

Q7VF76

Helicobacter hepaticus

298
DRQPEFTQIDIEM

Clostridium cellulolyticum

B8I3F1
Q6PI48

SFV

299
DRTGTGTLS

Citrobacter koseri, Corynebacterium

A8AP42, C3PEY5,
P04818

aurimucosum, Edwardsiella ictaluri,

C5BH86, A4WE03,

Enterobacter sp., Escherichia coli,
A8A3W0, B1IU17,

Escherichia coli, Escherichia coli,

P0A884, B7N759,

Escherichia coli, Escherichia coli,

P0A885, B7LY83,

Escherichia coli, Escherichia coli,

B7NVX2, C4ZZX9,

Escherichia coli, Escherichia coli,

B7MZC6, Q1R7I6,

Escherichia coli, Escherichia coli,

P0A886, Q0TE05,

Escherichia coli, Escherichia coli,

B7LF04, A1AF39,

Escherichia coli, Escherichia coli,

B7UHP4, B7MLH3,

Escherichia coli, Escherichia coli,

A7ZQT3, B7LNI2

Escherichia fergusonii

300
DRTGTGTLSVFG

Methylobacterium extorquens,

B7KQG2, B8IF20,
P04818

Methylobacterium nodulans, Neisseria

O33380

gonorrhoeae

301
DSGGARIQEG

Propionibacterium freudenreichii

Q8GBW6
P05166

302
DSKPGTIRGD

Clostridium thermocellum

A3DDC2
O60361

303
DSRGNPTVE

Aeromonas salmonicida, Aeromonas

A4SRC1, A0KGH3,
P06733

hydrophila, Aeromonas hydrophila,

Q8GE63, Q74K78,

Lactobacillus johnsonii, Lactobacillus

Q042F4, C3PFA7,

gasseri, Corynebacterium

Q6NI61, Q8NRS1,

aurimucosum, Corynebacterium

A4QCV0, Q8FQS7,

diphtheriae, Corynebacterium

C5B8X2, A4WDW7,

glutamicum, Corynebacterium

B7LWP5, Q1R7R4,

glutamicum, Corynebacterium

B1LQB2, B6I6H5,

efficiens, Edwardsiella ictaluri,

B7N715, P0A6P9,

Enterobacter sp., Escherichia
B7MZ75, B1IU62,

fergusonii, Escherichia coli,

P0A600, Q0TE80,

Escherichia coli, Escherichia coli,

A7ZQM2, A1AEW7,

Escherichia coli, Escherichia coli,

A8A3R4, B1XDI9,

Escherichia coli, Escherichia coli,

C4ZZT2, B7LXJ5,

Escherichia coli, Escherichia coli,

B7NV69, B5Z3E3,

Escherichia coli, Escherichia coli,

P0A6Q1, B7LEJ8,

Escherichia coli, Escherichia coli,

B7MLA0, B7UHJ5,

Escherichia coli, Escherichia coli,

Q011Z1, B8F8L5,

Escherichia coli, Escherichia coli,

Q7VNM6, A5UDD6,

Escherichia coli, Escherichia coli,

P43806, Q4QLX6,

Escherichia coli, Escherichia coli,

A5UI73, B5XV19,

Haemophilus somnus, Haemophilus

A6TD53, A9LZL4,

parasuis, Haemophilus ducreyi,

B4RMD8, Q5F8Z2,

Haemophilus influenzae,

Q9JU46, Q9JZ53,

Haemophilus influenzae,

A1KUB6, B4EUF7,

Haemophilus influenzae,

A6V1F3, Q9HXZ5,

Haemophilus influenzae, Klebsiella

B7V7V4, Q02RA7,

pneumoniae, Klebsiella pneumoniae,

A4XWS1, Q48F79,

Neisseria meningitidis, Neisseria

Q4ZWQ8, Q886M3,

gonorrhoeae, Neisseria gonorrhoeae,

Q3KH92, Q4KHF6,

Neisseria meningitidis, Neisseria

B1JB38, Q88MF9,

meningitidis, Neisseria meningitidis,

B0KSB9, Q1I646,

Proteus mirabilis, Pseudomonas

B2U9C3, Q8Y0B5

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

mendocina, Pseudomonas

savastanoi, Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas entomophila, Ralstonia

pickettii, Ralstonia solanacearum

304
DSRGNPTVEV

Bacillus cytotoxicus, Bacillus

A7GUR7, Q6HBF3,
P06733

thuringiensis, Bacillus anthracis,

C3P0A3, C1EZA0,

Bacillus cereus, Bacillus thuringiensis,

A0RKS3, Q81X78,

Bacillus anthracis, Bacillus cereus,

B7JFG3, C3LDI0,

Bacillus anthracis, Bacillus cereus,

Q631M2, A9VQ48,

Bacillus weihenstephanensis,

Q03AK4, Q65EN2,

Lactobacillus casei, Bacillus

B3WCVV7, Q88YH3,

licheniformis, Lactobacillus casei,

A7Z8Y1, P37869,

Lactobacillus plantarum, Bacillus

A8FHJ0, B7HW52,

methylotrophicus, Bacillus subtilis,

B9J4M4, Q72XY5,

Bacillus pumilus, Bacillus cereus,

B7HED2, Q815K8,

Bacillus cereus, Bacillus cereus,

B7IP20, Q03SL5,

Bacillus cereus, Bacillus cereus,

Q5WDK9, Q9K717,

Bacillus cereus, Lactobacillus brevis,

Q24MW5, B7GTK2,

Bacillus clausii, Bacillus halodurans,

A1A143, A0PYP4,

Desulfitobacterium hafniense,

Q181T5, A3DBQ5,

Bifidobacterium longum,

B8I4U1, C4LHL7,

Bifidobacterium adolescentis,

B1VFL0, B8J467,

Clostridium novyi, ptoclostridium

C6BSL8, Q316Q0,

difficile, Clostridium thermocellum,

C4XLR9, O32513,

Clostridium cellulolyticum,

B0S1G7, B2GM13,

Corynebacterium kropnstedtii,

A0ALD9, P64074,

Corynebacterium urealyticum,

P64075, Q71WX1,

Desulfovibrio desulfuricans,

B8DDA1, C1KY94,

Desulfovibrio salexigens,

C5C987, Q03GW5,

Desulfovibrio alaskensis,

Q6AAB8, Q8CPY3,

Desulfovibrio maeticus, Desulfovibrio

Q5HQV0, Q4L4K7,

vulgaris, Finegoldia magna, Kocuria

B9DJJ9, O69174,

rhizophila, Listeria welshimeri, Listeria

Q6GIL4, A8Z1A4,

monocytogenes, Listeria innocua,

A6QF85, P64079,

Listeria monocytogenes, Listeria

P64078, Q6GB54,

monocytogenes, Listeria

Q2YSE8, P99088,

monocytogenes, Micrococcus luteus,

Q5HHP1, Q2G028,

Pediococcus ntosaceus,

A5I0Y0, A7WZT2,

Propionibacterium acnes,

Q2FIL7, A6TZQ5,

Staphylococcus epidermidis,

Q49W03, Q9F2Q3,

Staphylococcus epidermidis,

Q82HH5

Staphylococcus haemolyticus,

Staphylococcus carnosus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Streptomyces coelicolor,

Streptomyces avermitilis

305
DSRGNPTVEVD

Fusobacterium nucleatum,

Q8RI55, A6L3M9,
P06733

Bacteroides vulgatus, Bacteroides

Q8KNX9, Q5LG64,

fragilis, Bacteroides fragilis,

Q89Z05, Q4JU51,

Bacteroides thetaiotaomicron,

B7KRB4, A9W6G9,

Corynebacterium jeikeium,

B1ZEJ8, B1LZU6,

Methylobacterium extorquens,

A5V3E8, B1GYL7

Methylobacterium extorquens,

Methylobacterium populi,

Methylobacterium radiotolerans,

Sphingomonas wittichii, Uncultured

termite

306
DTCQGDSGGP

Streptomyces exfoliatus,

P80420, P00775
P10323

Streptomyces griseus

307
DTGMGLERL

Clostridium phytofermentans,

A9KMW7, B1GZ43
Q5JTZ9

Uncultured termite

308
DTRGIFRVH

Propionibacterium acnes

Q6A5P0
P49591

309
DTRGIFRVHQF

Streptomyces avermitilis,

Q82FK8, Q9ZBX1,
P49591

Streptomyces coelicolor,

B1VP80

Streptomyces
griseus

310
DVANAVLDG

Lactobacillus delbrueckii, Escherichia

P34038, P21599
P30613

coli

311
DVAVIGVPD

Proteus mirabilis, Proteus sp.
B4EY25, Q8GB18
Q4G176

312
DVFCEKGVF

Parabacteroides distasonis

A6LI30
Q96NU7

313
DVGCGSGIL

Clostridium beijerinckii

A6LRN8
Q86X55

314
DVGCGTGILS

Clostridium thermocellum

A3DF23
O60678

315
DVINAAEKL

Escherichia coli, Escherichia coli,

P0A9T2, P0A9T0,
Q43175

Escherichia coli

P0A9T1

316
DVKVVILGQDPYH

Lactobacillus casei, Lactobacillus

B3WCZ5, Q03AI1
P13051

casei

317
DVKVVILGQDPYH

Campylobacter concisus,

A7ZAZ4, Q4QPM6,
P13051

G

Haemophilus influenzae,

A5UBC0

Haemophilus influenzae

318
DVKVVILGQDPYH

Bacillus subtilis, Escherichia

P39615, B7LUY5,
P13051

GP

fergusonii, Escherichia coli,

B7MYL3, Q1R8F2,

Escherichia coli, Escherichia coli,

B1LP93, A1AEB0,

Escherichia coli, Escherichia coli,

B7MIR5, B7UH19,

Escherichia coli, Escherichia coli,

A7ZQ25, Q0TEQ8,

Escherichia coli, Escherichia coli,

B7NRN6, B7N6H1,

Escherichia coli, Escherichia coli,

Q8X444, B5Z154,

Escherichia coli, Escherichia coli,

B615F5, P12295,

Escherichia coli, Escherichia coli,

B1IVP7, B1XBQ7,

Escherichia coli, Escherichia coli,

A8A392, C4ZYK3,

Escherichia coli, Escherichia coli,

B7M8J5, B7LDH3,

Escherichia coli, Escherichia coli,

Q8FF08, A6TCJ2,

Klebsiella pneumoniae, Klebsiella

B5XNF8, A3CN85,

pneumoniae, Streptococcus

A8AXM4

sanguinis, Streptococcus gordonii

319
DVKVVILGQDPYH

Desulfitobacterium hafniense,

Q24YA3, B8FSV8,
P13051

GPNQAHGL

Desulfitobacterium hafniense,

B2TQZ9, B2V017,

Clostridium botulinum, Clostridium

P43731, Q4L3Q7

botulinum, Haemophilus influenzae,

Staphylococcus haemolyticus

320
DVLDTWFSS

Desulfovibrio vulgaris, Geobacter

Q72E47, Q74BJ6
P26640

sulfurreducens

321
DVLDTWFSSGL

Helicobacter pylori, Helicobacter

P56000, Q9ZK61
P26640

pylori

322
DVLVATDVAS

Helicobacter pylori, Helicobacter

O25029, B9XXL6
Q9UJV9

pylori

323
DVLVNNAGI

Acinetobacter sp., Escherichia coli,
P50203, P0A9Q0,
P16152

Escherichia coli, Staphylococcus

P0A9P9, Q8CPI3,

epidermidis, Staphylococcus

Q5HPW0

epidermidis

324
DVLVNNAGIA

Corynebacterium glutamicum

Q9ZNN8
P16152

325
DVMDGHFVPNIT

Bacillus subtilis

O34557
Q20D12

326
DVSELTGFPE

Rhizobium sp., Rhizobium meliloti
C3MAR5, Q92KX6
P31939

327
DWIVGAGPAGLS

Acinetobacter baylyi, Pseudomonas

P94132, Q9HZP5
Q16134

AA

aeruginosa

328
DVWEHAYYL

Acinetobacter baylyi, Bacillus

Q59094, Q81LW0,
P04179

anthracis, Bacillus halodurans,

Q9KD10, Q81811,

Bacillus cereus, Enterococcus

Q838I4, P66828,

faecalis, Escherichia coli, Escherichia

P00448, P43725,

coli, Haemophilus influenzae,

O30826, Q92BR6,

Haemophilus ducreyi, Listeria

P28764, P28763

innocua, Listeria ivanovii, Listeria

P77929, P19665

monocytogenes, Porphyromonas

P53652, P0C0Q6,

gingivalis, Pseudomonas putida,

Q5HNZ5, Q8VQ15,

Pseudomonas aeruginosa,

Q9F326, Q49XZ6,

Staphylococcus epidermidis,

Q9K4V3, Q4L6Q3,

Staphylococcus epidermidis,

P0A0J2, Q6G913,

Staphylococcus epidermidis,

P99098, Q6GGE6,

Staphylococcus carnosus,

Q5HFK7, P0A0J1,

Staphylococcus saprophyticus,

P0A0J3, Q2YT26,

Staphylococcus xylosus,

Q2FGH0, Q2YUU9,

Staphylococcus haemolyticus,

P66831, P66832,

Staphylococcus aureus,

Q6GCZ1, Q6GKH2,

Staphylococcus aureus,

P66830, Q5HJN5,

Staphylococcus aureus,

Q2G261, Q2FKC6,

Staphylococcus aureus,

P0DF73, P0DF72,

Staphylococcus aureus,

Q8P0D4, Q5XBF8,

Staphylococcus aureus,

P0C011, P0C010,

Staphylococcus aureus,

P09738, P0A4J5,

Staphylococcus aureus,

P0A4J4, P0A4J3

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae

329
DVWEHAYYLQYK

Bacillus subtilis

O35023
P04179

N

330
DVYVNDAFGTAH

Ralstonia solanacearum

Q8Y1W6
P07205

RA

331
DVYVNDAFGTAH

Clostridium acetobutylicum

O52632
P07205

RAH

332
DWRTKKPVV

Lactobacillus delbrueckii,

Q041365, Q1GAS8
Q9N5E4

Lactobacillus delbrueckii

333
DYGPFGFLD

Escherichia coli, Escherichia coli,

B7L6H9, B6I8R1,
Q9BVL4

Escherichia coli, Escherichia coli,

Q0THC2, B1I050,

Escherichia coli, Escherichia coli,

B7N544, Q1RB89,

Escherichia coli, Escherichia coli,

Q8FH30, B7MAR7,

Escherichia coli, Escherichia coli,

A1ABP2, B7US45,

Escherichia coli, Escherichia coli,

B7MVI5, B7NTS5,

Escherichia coli, Escherichia coli,

P77649, C4ZYG8,

Escherichia coli, Escherichia coli,

B1XG13, A7ZMH3,

Escherichia coli, Escherichia coli,

A8A0P8, B1LE24,

Escherichia fergusonii

B7LQ82

334
DYYEILGVS

Escherichia fergusonii, Escherichia

B7LVP7, B1LFU5,
Q9NXW2

coli, Escherichia coli, Escherichia coli,

Q1RGI7, B6HZ11,

Escherichia coli, Escherichia coli,

B7N7N9, B1IRF9,

Escherichia coli, Escherichia coli,

Q8FLC5, A7ZVV8,

Escherichia coli, Escherichia coli,

B7M0B1, B7NHB7,

Escherichia coli, Escherichia coli,

B7MNM2, Q8XA65,

Escherichia coli, Escherichia coli,

B7L4D9, B7MAD6,

Escherichia coli, Escherichia coli,

B7UI60, A7ZHA5,

Escherichia coli, Escherichia coli,

P08622, B1XBE0,

Escherichia coli, Escherichia coli,

C4ZPU1, B5YYA8,

Klebsiella pneumoniae, Klebsiella

A6T4F5, B5Y241

pneumoniae

335
DYYEVLGLQ

Clostridium botulinum, Clostridium

B2TLZ8, B2V216,
Q7Z6W7

botulinum, Clostridium perfringens,

Q8XIT1, Q4QJW5,

Haemophilus influenzae,

B8F7S3, P48208,

Haemophilus parasuis, Haemophilus

P43735

ducreyi, Haemophilus influenzae

336
EAAPGTIRGD

Bacillus clausii

Q5WGT0
O00746

337
EAAPGTIRGDF

Bacillus cereus, Bacillus cereus,

Q81FQ4, Q73AY0,
O00746

Bacillus thuringiensis, Bacillus

Q6HL40, Q81SV8,

anthracis, Bacillus cereus

Q63DL7

338
EAGDGTTTATVLA

Arcobacter butzleri, Pseudomonas

A8ERY3, A4VP82,
P10809

stutzeri, Pseudomonas stutzeri

O33500

339
EAIKRDFGSF

Bacteroides fragilis

P53638
P04179

340
EALREVSAAR

Streptococcus pyogenes,

B5XJH4, Q8P2U5,
P15313

Streptococcus pyogenes,

P0DA08, Q9AIQ2,

Streptococcus pyogenes,

Q1JDW9, P0DA09,

Streptococcus pyogenes,

Q1JNS7, A2RC98,

Streptococcus pyogenes,

Q1J8S4, Q5XE49,

Streptococcus pyogenes,

Q1JIX4, Q48VL2,

Streptococcus pyogenes,

A8AUJ8, A3CK49,

Streptococcus pyogenes,

B1ICC8, B8ZK30,

Streptococcus pyogenes,

C1CES1, Q97QA9,

Streptococcus pyogenes,

B5E551, B2IP44

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus gordonii,

Streptococcus sanguinis,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

341
EASGTGNMKFML

Streptococcus pneumoniae

P29849
P06737

NGALT

342
EAYEVLSDA

Pseudomonas aeruginosa,

Q9HV44, Q02FR2,
O75190

Pseudomonas aeruginosa,

B7V1H2, A6VCL7,

Pseudomonas aeruginosa,

B0K1S4, B1J255,

Pseudomonas aeruginosa,

A4XYF5, Q88DU3,

Pseudomonas putida, Pseudomonas

A5W9A2, Q87WP1,

putida, Pseudomonas mendocina,

Q4ZNP8, Q48E63

Pseudomonas putida, Pseudomonas

putida, Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas savastanoi

343
EAYEVLSDE

Bacillus cytotoxicus, Staphylococcus

A7GT07, Q49Y21,
Q96EY1

saprophyticus, Staphylococcus

Q5HNW7, Q8CP18,

epidermidis, Staphylococcus

B9DNJ9

epidermidis, Staphylococcus

carnosus

344
EAYEVLSDP

Pseudomonas stutzeri

Q6VAY5
Q9UDY4

345
EAYEVLSDS

Pseudomonas fluorescens

Q4KIH0
Q8NHS0

346
ECKIGIMPG

Staphylococcus aureus,

P99070, P66866,
P53597

Staphylococcus aureus,

Q5HGI6, Q8NX01,

Staphylococcus aureus,

Q6G9W7, Q6GHI9,

Staphylococcus aureus,

Q5HPU4, Q8CPH4

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

347
EDPVTGSAH

Pseudomonas aeruginosa,

Q9I073, Q9HY42
P30039

Pseudomonas aeruginosa

348
EDQIYRIDHYLGK

Bacillus subtilis

P54547
P11413

349
EDRIVKRFL

Sphingomonas wittichii

A5VDD4
A6NJ78

350
EDVKKRI LE

Finegoldia magna

B052N4
P36776

351
EEARGDQCD

Bacillus thuringiensis, Bacillus cereus,

Q6HBM0, B7JEJ3,
P56192

Bacillus cereus, Bacillus thuringiensis,

C1EYD5, A0RKM3,

Bacillus anthracis, Bacillus anthracis,

C3LD96, C3P025,

Bacillus anthracis

Q81XF9

352
EEGDLGPVYG

Pseudomonas putida

A5WAK1
P04818

353
EEHDQEGRVI

Bacillus subtilis

P37454
P27695

354
EEIFGPVLVV

Escherichia coli

P23883
O02252

355
EEIKKAYRK

Bacteroides thetaiotaomicron,

Q8A8C3, Q5LED4,
Q8WW22

Bacteroides fragilis, Bacteroides

Q64VI7

fragilis

356
EEMRQSLRI

Streptomyces avermitilis,

Q82DX8, Q9XAQ7
O75306

Streptomyces coelicolor

357
EEMRQSLRII

Akkermansia muciniphila,

B2ULZ0, B1W516
O75306

Streptomyces griseus

358
EFTQIDIEMSFVD

Desulfovibrio vulgaris

Q72507
Q6PI48

359
EFYMAYADY

Aeromonas hydrophila, Aeromonas

A0KNK7, A4SJK0
Q15046

salmonicida

360
EGDSAFGFSGME

Escherichia coli, Escherichia coli

P0AFI0, P0AFII
Q9UJ83

361
EGGGCSGFQY

Stenotrophomonas maltophilia,

B2FJT4, B4SLD1
Q86U28

Stenotrophomonas maltophilia

362
EGGVHRVQRVP

Akkermansia muciniphila

B2UL99
Q9UGC7

363
EGHPDKICD

Corynebacterium aurimucosum

C3PG24
Q00266

364
EGHPDKICDQISD

Bacillus licheniformis, Bacillus

Q65FV8, Q9K7Q9,
Q00266

halodurans, Bacillus

A7Z7Y9, P54419,

methylotrophicus, Bacillus subtilis,

A8FGH7, A7GU40,

Bacillus pumilus, Bacillus cytotoxicus,

C1EW36, A0RJZ7,

Bacillus cereus, Bacillus thuringiensis,

B9J265, Q632S5,

Bacillus cereus, Bacillus cereus,

C3PCC4, B7JT32,

Bacillus anthracis, Bacillus cereus,

Q81KI0, C3LAZ9,

Bacillus anthracis, Bacillus anthracis,

Q6HCB4, B7HSV6,

Bacillus thuringiensis, Bacillus cereus,

B7H9C7, Q8I6Q8,

Bacillus cereus, Bacillus cereus,

Q72YV6, B7IL28,

Bacillus cereus, Bacillus cereus,

A9VLC6, QI8CL7

Bacillus weihenstephanensis,

ptoclostridium difficile

365
EGHPDKICDQISD

Bacillus clausii, Desulfitobacterium

Q5WDZ8, B8FSB9,
Q00266

A

hafniense, Bifidobacterium animalis,

B8DTW8, Q97F85

Clostridium acetobutylicum

366
EGHPDKICDQISD

Clostridium perfringens, Clostridium

Q0SR05, Q0TND4,
Q00266

AVLDA

perfringens, Clostridium botulinum,

C1FQQ5, Q898W7,

Clostridium tetani, Clostridium

B1IE45, A5HY62,

botulinum, Clostridium botulinum,

A7F0I8, A7G9S1,

Clostridium botulinum, Clostridium

B1KST9, A9KL72,

botulinum, Clostridium botulinum,

A3DHM4, B8I4C1

Clostridium phytofermentans,

Clostridium thermocellum, Clostridium

cellulolyticum

367
EGWLAEHMLIL

Streptomyces avermitilis

Q82171
P35558

368
EGYNTWGE

Aggregatibacter

P23702
Q9NUT2

actinomycetemcomitans

369
EGYPGKRYYGG

Acinetobacter radioresistens,

O85718, Q6FA66,
P34897

Acinetobacter baylyi, Acinetobacter

A3M736, B0VBB3,

baumannii, Acinetobacter baumannii,

B2HUY9, B7GZR6,

Acinetobacter baumannii,

B712R7, B0VLF5,

Acinetobacter baumannii,

Q046F8, Q74LC1,

Acinetobacter baumannii,

Q03QY0, A7Z9Q9,

Acinetobacter baumannii,

B2GAT4, Q65DW5,

Lactobacillus gasseri, Lactobacillus

A8FIC1, Q8IJY4,

johnsonii, Lactobacillus brevis,

C3P1G5, C3LFJ0,

Bacillus methylotrophicus,

B7JGP1, C1F0N9,

Lactobacillus fermentum, Bacillus

Q24MM6, B8FZ69,

licheniformis, Bacillus pumilus,

Q8A9S7, A6L5K3,

Bacillus anthracis, Bacillus anthracis,

Q5LD58, Q64U78,

Bacillus anthracis, Bacillus cereus,

A7I3S9, Q97GVI,

Bacillus cereus, Desulfitobacterium

A3DEB1, A5N7P5,

hafniense, Desulfitobacterium

B9E156, B812N8,

hafniense, Bacteroides

A9KSH6, B8J189,

thetaiotaomicron, Bacteroides

Q831F9, B0S1N3,

vulgatus, Bacteroides fragilis,

Q03EK4, Q7MXW0,

Bacteroides fragilis, Campylobacter

B2RGR2, B4EZV5,

hominis, Clostridium acetobutylicum,

A4VI36, Q88Q27,

Clostridium thermocellum, Clostridium

Q3K5K9, Q9HTE9,

kluyveri, Clostridium kluyveri,

Q9I138, Q88R12,

Clostridium cellulolyticum, Clostridium

Q4K5R9, Q4K4P6,

phytofermentans, Desulfovibrio

Q48CP3, Q48DU7,

desulfuricans, Enterococcus faecalis,

Q4ZNH2, Q3K6J0,

Finegoldia magna, Pediococcus

Q87WC1, Q4ZM83,

ntosaceus, Porphyromonas gingivalis,

Q88AD1, Q8Y1G1,

Porphyromonas gingivalis, Proteus

B2U7G7, Q03L77,

mirabilis, Pseudomonas stutzeri,

Q5M0B4

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas putida,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas savastanoi,

Pseudomonas savastanoi,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas syringae, Ralstonia

solanacearum, Ralstonia pickettii,

Streptococcus thermophilus,

Streptococcus thermophilus

370
EIAGPGFIN

Acinetobacter baumannii,

B0VBN5, B2I0Y7,

Acinetobacter baumannii,

B7I1U9, B7H2A9,
P54136

Acinetobacter baumannii,

Q72X85, Q6HAS1,

Acinetobacter baumannii, Bacillus

Q81Q08, Q630N6,

cereus, Bacillus thuringiensis, Bacillus

Q5WB34, Q81JT7,

cereus, Bacillus cereus, Bacillus

Q9K6C1, Q6A5X8,

clausii, Bacillus anthracis, Bacillus

B9M252, C6E805,

halodurans, Propionibacterium acnes,

B5EEF0, Q0I3B0,

Geobacter daltonii, Geobacter sp.,
A5UCH1, Q40L12,

Geobacter bemidjiensis, Haemophilus

P43832, Q7VP38,

somnus, Haemophilus influenzae,

A5UJ40, Q3KJB3,

Haemophilus influenzae,

C3KAH3, Q4KJK0,

Haemophilus influenzae,

B9DKQ7

Haemophilus ducreyi, Haemophilus

influenzae, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Staphylococcus

carnosus

371
EIFLRELISNA

Desulfitobacterium hafniense

Q24VT7
P14625

372
EIFLRELISNASDA

Acinetobacter baylyi, Clostridium

Q6FF82, Q0TU16,
P14625

perfringens, Clostridium perfringens,

Q0VV8, Q8XNC2

Clostridium perfringens

373
EIGGGSIRI

Fusobacterium nucleatum

Q8RGJ4
Q6PI48

374
EIGVASTKA

Neisseria meningitidis, Neisseria

Q9K1P9, Q9JWN9,
Q06210

meningitidis, Neisseria gonorrhoeae

Q5F584

375
EIKKAYRKLA

Corynebacterium efficiens,

Q8FNF5, Q8NNB4,
Q8WW22

Corynebacterium glutamicum,

Q6NG14

Corynebacterium diphtheriae

376
EKSPYLLQHA

Bacillus subtilis, Bacillus subtilis

P37512, P37509
Q8TB22

377
ELGGKSPLI

Escherichia coli, Escherichia coli,

Q0TKW0, B1J0W5,
Q3SY69

Escherichia coli, Escherichia coli,

P17445, B1XET7,

Escherichia coli, Escherichia coli,

A7ZWV5, B7L441,

Escherichia coli, Escherichia coli,

Q7AH91, B5Z1R1,

Escherichia coli, Escherichia coli,

B6I075, B7N8L4,

Escherichia coli, Escherichia coli,

B1LIJ8, Q8FKI8,

Escherichia coli, Escherichia coli,

B7UJG5, A7ZI51,

Escherichia coli, Escherichia coli,

B7MCD1, B7M2V6,

Escherichia coli, Pseudomonas

B7NK50, A4XPI6,

mendocina, Pseudomonas

C3K3D2, Q88AE9,

fluorescens, Pseudomonas syringae,

Q4ZM62, Q48CM6,

Pseudomonas syringae,

A4VKC2, Q2KB42,

Pseudomonas savastanoi,

B5ZUG3, B3PTE1,

Pseudomonas stutzeri, Rhizobium

C3MIE5, P54222,

etli, Rhizobium leguminosarum,

Q985M6

Rhizobium etli, Rhizobium sp.,

Rhizobium meliloti, Rhizobium loti

378
ELGGKSPLII

Acinetobacter baumannii,

A3M365, B2HV80,
Q3SY69

Acinetobacter baumannii,

B0V944, B71896,

Acinetobacter baumannii,

B7GYG4, Q6FDF8,

Acinetobacter baumannii,

B0VST2, B5Y007,

Acinetobacter baumannii,

Q3K5H4, B0KN18,

Acinetobacter baylyi, Acinetobacter

Q1IG69, Q88CVV7,

baumannii, Klebsiella pneumoniae,

A5WA96, B1J2K9

Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

putida

379
ELGGKSPLIIF

Pseudomonas aeruginosa,

A6VEI4, Q9HTJ1,
Q3SY69

Pseudomonas aeruginosa,

B7V5R4, Q02DY9,

Pseudomonas aeruginosa,

Q4K4K8

Pseudomonas aeruginosa,

Pseudomonas fluorescens

380
ELIASENFAS

Clostridium novyi

A0PZX4
P34896

381
ELLGRVVDALGN

Acinetobacter baylyi, Acinetobacter

Q6FFK2, B0VBP5,
P25705

baumannii, Acinetobacter baumannii,

B7I1W2, B2I100,

Acinetobacter baumannii,

A3M142, B7H296,

Acinetobacter baumannii,

A5WBA5, B0KRB0,

Acinetobacter baumannii,

B1JFU3, Q88BX2,

Pseudomonas putida, Pseudomonas

C3K1E8, B7V793,

putida, Pseudomonas putida,

Q02DF2, Q9HT18,

Pseudomonas putida, Pseudomonas

A6VF34, Q87TT2,

fluorescens, Pseudomonas

Q3K439, A4Y189,

aeruginosa, Pseudomonas

Q4ZL22, Q48BG3,

aeruginosa, Pseudomonas

Q4K3A7, Q1I215,

aeruginosa, Pseudomonas

A4VS64

aeruginosa, Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas mendocina,

Pseudomonas syringae,

Pseudomonas savastanoi,

Pseudomonas fluorescens,

Pseudomonas entomophila,

Pseudomonas stutzeri

382
ELNRKVLADLA

Clostridium cellulolyticum,

B8I169, Q30Y14,
Q9BYC9

Desulfovibrio alaskensis,

B8J4E1

Desulfovibrio desulfuricans

383
EMNLSETAF

Bacillus halodurans

Q9KG32
P30039

384
EMRQSLRII

Pseudomonas aeruginosa,

A6V4E7, Q02ND1,
O75306

Pseudomonas aeruginosa,

Q9I0J9

Pseudomonas aeruginosa

385
ENGMDVFRVFD

Propionibacterium freudenreichii

Q70AC7
P11498

386
ENIRRIAEV

Bacteroides fragilis, Bacteroides

Q5LES5, Q64VR1,
Q95340

fragilis, Bacteroides thetaiotaomicron

Q8AAQ1

387
ENLRWDAS

Staphylococcus aureus,

Q6GDJ1, A8Z5A4,
Q8NE62

Staphylococcus aureus,

P60336, P60337,

Staphylococcus aureus,

A6QK99, Q5HCU1,

Staphylococcus aureus,

Q2YWJ5, A5IW37,

Staphylococcus aureus,

Q2FV11, Q2FDP9,

Staphylococcus aureus,

A7X6Z3, A6U4Z2,

Staphylococcus aureus,

Q4L9D7, Q8CMY2,

Staphylococcus aureus,

Q5HL11

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

388
ENYVHRIGRTGR

Listeria monocytogenes

Q8Y7M8
Q9UJV9

389
EPGAEEKFK

Lactobacillus reuteri, Lactobacillus

B2G6W4, A5VJE8
P25685

reuteri

390
EPIGVCGQI

Bacillus subtilis

P71016
Q94788

391
EPTSGNTGI

Escherichia coli, Escherichia coli

P0ABK6, P0ABK5
P35520

392
EPTSGNTGIGLA

Staphylococcus aureus,

Q6GBX5, P63872,
P35520

Staphylococcus aureus,

Q6GJF8, P63871,

Staphylococcus aureus,

P63870, Q5HIG2,

Staphylococcus aureus,

Q8CMT6, Q5HRP1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

393
ERAYDIYSRLL

Fusobacterium nucleatum,

Q8RHJ8, Q30Z79,
Q16740

Desulfovibrio alaskensis,

A1VE85, Q72CE8,

Desulfovibrio vulgaris, Desulfovibrio

B8DNL4, B8IYM2

vulgaris, Desulfovibrio vulgaris,

Desulfovibrio desulfuricans

394
ERAYDIYSRLLR

Desulfovibrio maeticus

C4XH03
Q16740

395
ERFSYYGMRAIL

Bacillus subtilis

P94408
P46059

396
ERGTFSHRH

Staphylococcus haemolyticus,

Q4L6C4, Q5HPC6,
Q9ULD0

Staphylococcus epidermidis,

Q8CP83, Q49XM5

Staphylococcus epidermidis,

Staphylococcus saprophyticus

397
ERIPERWHA

Bacillus subtilis, Pseudomonas

P42234, Q9I1W8,
P04040

aeruginosa, Rhizobium meliloti

Q9X576

398
ERKTGARGLR

Desulfovibrio vulgaris, Desulfovibrio

vulgaris

A1VE84, Q72CE7
O76031

399
ERKTGARGLRSI

Streptococcus equi, Streptococcus

B4U360, C0M9R7,
O76031

equi, Streptococcus equi,

C0MEW5, Q8DZ10,

Streptococcus agalactiae,

Q8E4L8, Q3K0K0,

Streptococcus agalactiae,

A2RF17, Q5XCM0,

Streptococcus agalactiae,

Q1JC93, Q1JM77,

Streptococcus pyogenes,

B5XL03, B9DU73,

Streptococcus pyogenes,

Q8DUI0, Q03LN0,

Streptococcus pyogenes,

Q5M5B0, Q5M0S4,

Streptococcus pyogenes,

A8AX69, A3CMV1,

Streptococcus pyogenes,

B5E6L2, B8ZLT1,

Streptococcus uberis, Streptococcus

B2IR87, C1CLR8,

mutans, Streptococcus thermophilus,

C1CFF2, P63792,

Streptococcus thermophilus,

P63791, C1C8G0,

Streptococcus thermophilus,

Q04JH9

Streptococcus gordonii,

Streptococcus sanguinis,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

400
ERLEFLGDAV

Bifidobacterium longum

Q8G7H1
Q9NRR4

401
ESMLTGESVPV

Enterococcus hirae

P32113
Q9H7F0

402
ESVKAASELY

Desulfovibrio vulgaris, Desulfovibrio

A1VE01, Q72C58,
P23434

vulgaris, Desulfovibrio alaskensis

Q311A6

403
ESVKAASELYSPL

Desulfovibrio vulgaris

B8DP97
P23434

404
ESVRGKDVFIIQ

Campylobacter jejuni

Q9PP15
O60256

405
ETGGLSGKPL

Rhizobium loti

Q98689
Q02127

406
ETLGGTCLNVGC

Pseudomonas aeruginosa

Q9HUY1
P09622

407
ETMLGDVAV

Ralstonia solanacearum

Q8XX80
P26640

408
ETMLGDVAVAVH

Corynebacterium jeikeium,

Q4JWU8, Q8FN65,
P26640

P

Corynebacterium efficiens,

Q6NFV0, Q8NN37

Corynebacterium diphtheriae,

Corynebacterium glutamicum

409
ETRYRQRYLDLI

Edwardsiella ictaluri, Proteus mirabilis

C5BAR6, B4F0M6
Q15046

410
ETVGVGQSE

Escherichia coli

P27254
Q8IVH4

411
ETYGCQMNV

Bacteroides vulgatus,

A6KZJ2, A6LEM6,
Q965Z6

Parabacteroides distasonis,

Q8A2W0, Q650P7,

Bacteroides thetaiotaomicron,

Q5LJ70, Q7MAW4,

Bacteroides fragilis, Bacteroides

B2RKG6

fragilis, Porphyromonas gingivalis,

Porphyromonas gingivalis

412
EVAKLFADAG

Clostridium acetobutylicum

Q97MT8
Q43252

413
EVEGLADLI

Rhizobium meliloti, Rhizobium etli,

Q92KW1, B3PS53,
Q969Y2

Rhizobium leguminosarum,

Q1MA18, Q2K2S0

Rhizobium etli

414
EVGPRDGLQNE

Bacillus subtilis, Pseudomonas

Q34873, P13703
Q8TB92

mevalonii

415
EVRGGGRKP

Corynebacterium glutamicum,

Q8NT08, A4QB10,
Q9BYD3

Corynebacterium glutamicum,

C3PKQ3

Corynebacterium aurimucosum

416
EVRGGGRKPW

Bacillus clausii, Bacillus halodurans,

Q5WLR1, Q9Z9L3,
Q9BYD3

Bacillus licheniformis, Bacillus

Q65PA6, A9VP78,

weihenstephanensis, Bacillus

Q6HPQ7, Q63H89,

thuringiensis, Bacillus cereus, Bacillus

Q81J41, B9IZJ5,

cereus, Bacillus cereus, Bacillus

A0R8I1, B7HQU5,

thuringiensis, Bacillus cereus, Bacillus

B7IT20, B7HJ49,

cereus, Bacillus cereus, Bacillus

C1ET40, Q81VS9,

cereus, Bacillus anthracis, Bacillus

Q73F95, B7JKC0,

cereus, Bacillus cereus, Bacillus

C3LJ83, C3P9Q6,

anthracis, Bacillus anthracis, Bacillus

P42921, A7ZQN9,

subtilis, Bacillus methylotrophicus,

A8F986, B8G1W7,

Bacillus pumilus, Desulfitobacterium

Q250N1, C4ZBD5,

hafniense, Desulfitobacterium

A3DJH3, B0RZU1,

hafniense, Eubacterium rectale,

P61054, P61055,

Clostridium thermocellum, Finegoldia

B8DB09, Q71WE7,

magna, Listeria innocua, Listeria

C1KZH9, A0ALW7

monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Listeria welshimeri

417
EVTLLGQNVN

Corynebacterium urealyticum,

B1VDD8, A4QEV7,
Q96SZ6

Corynebacterium glutamicum,

Q8NP67, Q6NGR0,

Corynebacterium glutamicum,

Q8FPD5, Q4JV79,

Corynebacterium diphtheriae,

A6V0C9, Q51470,

Corynebacterium efficiens,

Q02SE8, Q48DN8,

Corynebacterium jeikeium,

Q4ZN97, Q4K5I3,

Pseudomonas aeruginosa,

Q3K6B7, Q87VY1,

Pseudomonas aeruginosa,

B2UFP3, Q8Y206,

Pseudomonas aeruginosa,

Q98BK3

Pseudomonas savastanoi,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas syringae, Ralstonia

pickettii, Ralstonia solanacearum,

Rhizobium loti

418
EVTLLGQNVNS

Desulfitobacterium hafniense,

Q24X58, Q39TA3,
Q96SZ6

Geobacter metallireducens,

B5EE49

Geobacter bemidjiensis

419
EWWNDLWLNE

Streptomyces lividans

Q11010
P15144

420
EYCLGPTHEE

Desulfovibrio desulfuricans

B8IZD1
Q7L3T8

421
EYCLGPTHEEA

ptoclostridium difficile

Q18CD2
Q7L3T8

422
EYLARWFD

Corynebacterium efficiens,

Q8FTA8, Q8N098
P21399

Corynebacterium glutamicum

423
EYRGYDSAG

Fusobacterium nucleatum

Q8RG65
Q06210

424
EYSRSGNPTR

Helicobacter pylori, Helicobacter

P56069, Q1M0P5,
P32929

pylori, Helicobacter pylori

Q9ZMW7

425
FALCGFANF

Escherichia coli, Escherichia coli

P33021, P33024
O00377

426
FALCGFANFSSI

Bacillus subtilis

O32115
O00377

427
FALKPMNCPGH

Rhizobium loti, Rhizobium sp.,
Q98LR2, C3MB49,
A2RTX5

Rhizobium etli, Rhizobium etli,

Q2K859, B3PNV4,

Rhizobium leguminosarum,

B5ZQK2, Q92Q130

Rhizobium meliloti

428
FANFSSIGI

Bacillus subtilis, Escherichia coli,

P39141, P0AFF2,
O00377

Escherichia coli

P0AFF3

429
FAPEVAWVT

Bacillus cereus, Bacillus cereus,

Q81IE9, Q63GI2,
P07814

Bacillus thuringiensis, Bacillus cereus,

Q6HNZ7, Q73E50,

Bacillus thuringiensis, Bacillus

A0R9A0, Q81Z76,

anthracis, Eubacterium rectale,

C4ZC24, A0Q213,

Clostridium novyi, Clostridium

B8I5R4, C3KUV8,

cellulolyticum, Clostridium botulinum,

B1L224, B1IF12,

Clostridium botulinum, Clostridium

A7GIT0, C1FM10,

botulinum, Clostridium botulinum,

A51768, A7FYU0,

Clostridium botulinum, Clostridium

Q9L4Q8, A9KL35,

botulinum, Clostridium botulinum,

Q18CD7, C4Z1D7

Clostridium sticklandii, Clostridium

phytofermentans, ptoclostridium

difficile, Eubacterium eligens

430
FCAGADLKER

Bacillus subtilis

O34893
Q13825

431
FCKEFNERTKD

Selenomonas ruminantium

Q84IF5
Q9Y3B7

432
FDPLDGSSNID

Acinetobacter baumannii,

A3M7W9, B0VDK0,
P09467

Acinetobacter baumannii,

B0VT80, B2HWU2,

Acinetobacter baumannii,

A1VD23, Q72AZ9,

Acinetobacter baumannii,

C6BTU7, Q30ZN0,

Desulfovibrio vulgaris, Desulfovibrio

Q9JZH1, A1KTU6,

vulgaris, Desulfovibrio salexigens,

A1IRQ3, A9LYX9,

Desulfovibrio alaskensis, Neisseria

Q5F8C3, B4RLD4,

meningitidis, Neisseria meningitidis,

A4VGC9, Q02EQ6,

Neisseria meningitidis, Neisseria

A4XPL2, Q9HU73,

meningitidis, Neisseria gonorrhoeae,

B7V3K3, A6VDM7,

Neisseria gonorrhoeae,

B1J2P7, B0KM65,

Pseudomonas stutzeri, Pseudomonas

A5WA74, Q1I3Q0,

aeruginosa, Pseudomonas

Q88CY9, Q3KJG0,

mendocina, Pseudomonas

C3K7D6, Q4KJP6,

aeruginosa, Pseudomonas

Q87UX4, Q4ZZI0,

aeruginosa, Pseudomonas

Q48PL3, B2U8C4,

aeruginosa, Pseudomonas putida,

Q8XXI7, B2FU10,

Pseudomonas putida, Pseudomonas

B4SR24

putida, Pseudomonas entomophila,

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas savastanoi, Ralstonia

pickettii, Ralstonia solanacearum,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

433
FDRERIPERVVHA

Pseudomonas aeruginosa,

Q59635, P46206
P04040

Pseudomonas syringae

434
FDRERIPERVVHA

Helicobacter pylori, Helicobacter

Q9ZKX5, P77872
P04040

KG

pylori

435
FDRILASRMGV

Haemophilus ducreyi

Q8GNC1
Q01813

436
FDRILLDAPCS

Escherichia coli

Q0TCH3
Q8TEA1

437
FDTAPTGHT

Escherichia coli, Escherichia coli

P52145, P08690
Q43681

438
FEYVYFARPDS

Escherichia coli, Rhizobium etli

P0AG16, P77935
Q06203

439
FFYPLDFTFVCPT

Clostridium pasteurianum

P23161
Q06830

El

440
FGHPEVYIL

Bacillus pseudofirmus, Bacillus sp.
Q04440, P16262
P00395

441
FGHPEVYILILP

Bacillus subtilis

P24010
P00395

442
FGICLGHQL

Listeria monocytogenes, Listeria

Q71YI0, Q8Y664,
P27708

monocytogenes, Listeria innocua

Q92AH2

443
FGLGAEVGIST

Arcobacter butzleri

A8EVN0
P54886

444
FGLPAENAA

Fusobacterium nucleatum,

Q8RIQ3, Q24SP5,
Q15031

Desulfitobacterium hafniense,

B8FUR3, Q182K8

Desulfitobacterium hafniense,

ptoclostridium difficile

445
FGMGCFWGAER

Pseudomonas aeruginosa,

Q02EZ9, Q9HUF1,
Q9UJ68

Pseudomonas aeruginosa,

B7V3B1, Q4ZM24,

Pseudomonas aeruginosa,

Q92SY7

Pseudomonas syringae, Rhizobium

mel iloti

446
FGMIPEFVGR

Clostridium phytofermentans

A9KSX1
O76031

447
FGSFDKFKE

Pseudomonas aeruginosa,

P53641, Q88PD5,
P04179

Pseudomonas putida, Pseudomonas

P09223

putida

448
FGTGAVKITPAHD

Lactobacillus casei, Clostridium

P36420, Q97GG8,
P26640

acetobutylicum, Clostridium tetani,

Q891R5,
Q8XJ42

Clostridium perfringens

449
FGTIDSWLIW

Streptomyces avermitilis

Q827G1
Q14409

450
FGWDCHGLP

Corynebacterium diphtheriae,

Q6NGD7, Q4JW85
P41252

Corynebacterium jeikeium

451
FHAIYWPAFL

Campylobacter jejuni, Helicobacter

Q9PP85, Q9ZKG9,
Q96GW9

pylori, Helicobacter pylori

P56127

452
FHSLEDRIVK

Methylobacterium sp., Fusobacterium
B0UFI0, Q8R6F5,
A6NJ78

nucleatum, ptoclostridium difficile,

Q182Z2, A3DE34,

Clostridium thermocellum, Clostridium

A6LTS0, B2TS30,

beijerinckii, Clostridium botulinum,

B2V4W0, Q89464,

Clostridium botulinum, Clostridium

Q97H81, B1LYT9,

tetani, Clostridium acetobutylicum,

B7KU77, C5ATZ5,

Methylobacterium radiotolerans,

A9WV37, B1Z8U3,

Methylobacterium extorquens,

B8IMX2, A1KVM4,

Methylobacterium extorquens,

Q9JSY9, Q9KOZ0,

Methylobacterium extorquens,

B4RQD7, A9M2I4,

Methylobacterium populi,

Q5F6K7

Methylobacterium nodulans, Neisseria

meningitidis, Neisseria meningitidis,

Neisseria meningitidis, Neisseria

gonorrhoeae, Neisseria meningitidis,

Neisseria gonorrhoeae

453
FHSLEDRIVKRF

Rhizobium loti

Q98KA5
A6NJ78

454
FIAGADINM

Citrobacter koseri, Enterobacter sp.,
A8ADP2, A4WCVV6,
P40939

Escherichia coli, Escherichia coli,

Q8FFG4, B7LBJ5,

Escherichia coli, Escherichia coli,

A7ZPF8, B61604,

Escherichia coli, Escherichia coli,

B7M6M2, Q8XCP2,

Escherichia coli, Escherichia coli,

B7NP24, B7N5V2,

Escherichia coli, Escherichia coli,

B1LME7, B7MGV7,

Escherichia coli, Escherichia coli,

Q1R972, A1ADI8,

Escherichia coli, Escherichia coli,

A8A2L0, B7UFZ8,

Escherichia coli, Escherichia coli,

B1IXA5, B7MY16,

Escherichia coli, Escherichia coli,

B5YXY4, Q0TFA6,

Escherichia coli, Escherichia coli,

P77399, B1X9L4,

Escherichia coli, Escherichia

C4ZVN2, B7LLD0,

fergusonii, Klebsiella pneumoniae,

B5XWV2, A6TC19

Klebsiella pneumoniae

455
FIGRSNVGKSSLI

Parabacteroides distasonis,

A6LBY4, Q7MX68,
Q8N3Z3

Porphyromonas gingivalis,

B2RL89

Porphyromonas gingivalis

456
FITHLHGDH

Lactobacillus casei, Lactobacillus

B3WE54, Q039J0
Q9H777

casei

457
FITPVPGGVGPMT

Listeria monocytogenes, Listeria

Q71ZW2, C1L2R6
P11586

monocytogenes

458
FITPVPGGVGPMT

Haemophilus parasuis

B8F605
P11586

VAMLMQ

459
FKQLLMVGG

Acinetobacter baumannii,

B0V550, B2HYL7,
Q6PI48

Acinetobacter baumannii,

B7I8M5, B7GWN1,

Acinetobacter baumannii,

A3M8Q6, B0VRC7,

Acinetobacter baumannii,

A7GT84, B9IYX5,

Acinetobacter baumannii,

B7HQG0, Q730D1,

Acinetobacter baumannii, Bacillus

Q634E3, B7HE37,

cytotoxicus, Bacillus cereus, Bacillus

B7IIR4, Q81LI7,

cereus, Bacillus cereus, Bacillus

C3P990, Q6HDC3,

cereus, Bacillus cereus, Bacillus

C1ESU7, A0RJ11,

cereus, Bacillus anthracis, Bacillus

B7JPY8, C3L608,

anthracis, Bacillus thuringiensis,

Q817X8, A9VIM8,

Bacillus cereus, Bacillus thuringiensis,

C4LIW2, P56459,

Bacillus cereus, Bacillus anthracis,

Q1CTQ7, B6JLK1,

Bacillus cereus, Bacillus

Q9ZLL9

weihenstephanensis,

Corynebacterium kropnstedtii,

Helicobacter pylori, Helicobacter

pylori, Helicobacter pylori,

Helicobacter pylori

460
FKQLYDKGL

Bifidobacterium longum

Q8G3I2
P41252

461
FLKHIERTR

Clostridium botulinum

B2TK70
A4D1E9

462
FLRELISNASDA

Aeromonas hydrophila, Aeromonas

A0KL53, A4SLY0,
P14625

salmonicida, Bacillus lichen iformis

Q65CZ5

463
FLRHIERCR

Propionibacterium acnes

Q6A9H8
Q9H4K7

464
FLSNGPGDP

Haemophilus ducreyi, Neisseria

Q7VP66, Q9JXX4,
P27708

meningitidis, Neisseria meningitidis,

Q9JVZ6, Q50983,

Neisseria gonorrhoeae,

Q87WP3, Q88DU5,

Pseudomonas syringae,

P38098, Q8XZ85,

Pseudomonas putida, Pseudomonas

Q981A7

aeruginosa, Ralstonia solanacearum,

Rhizobium loti

465
FLSNGPGDPA

Acinetobacter baylyi, Desulfovibrio

Q6F8M7, A1VA26,
P27708

vulgaris, Desulfovibrio vulgaris,

Q726J4, Q8FLB1,

Escherichia coli, Escherichia coli,

P0A6F2, P0A6F1,

Escherichia coli, Rhizobium meliloti

Q92N95

466
FLSQSGETAD

Bacillus subtilis, Bacillus subtilis

EOU070, P0CI73
Q06210

467
FLWVVDFPL

Uncultured termite

B1GZY6
Q6PI48

468
FMPVGTQAT

Clostridium thermocellum,

A3DE13, Q03ER2,
Q9BXR0

Pediococcus ntosaceus,

A4VW51, A4W2F8,

Streptococcus suis, Streptococcus

B1I9B4, Q8E1F9,

suis, Streptococcus pneumoniae,

Q8E6X6, Q3K2Y7,

Streptococcus agalactiae,

A8AUL3, Q5M2K9,

Streptococcus agalactiae,

Q03IQ5, Q5LY05,

Streptococcus agalactiae,

A3CK60, B9DVZ9,

Streptococcus gordonii,

C0MAH5, C1CN05,

Streptococcus thermophilus,

Q1JIT0, P0DF87,

Streptococcus thermophilus,

Q48VG9, A2RCC9,

Streptococcus thermophilus,

Q1JNN4, Q1JDS0,

Streptococcus sanguinis,

P66910, P0DF86,

Streptococcus uberis, Streptococcus

C0MEV8, Q9A1L6,

equi, Streptococcus pneumoniae,

Q1J8P1, B5XJL3,

Streptococcus pyogenes,

C1CGY8, B2IMN3,

Streptococcus pyogenes,

P66908, B5E2X9,

Streptococcus pyogenes,

P66907, B8ZPB8,

Streptococcus pyogenes,

Q04163, C1CTW4,

Streptococcus pyogenes,

C1CAA6, Q5XE18,

Streptococcus pyogenes,

Q8DVZ3

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus equi, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus mutans

469
FMQKEIFEQP

Ralstonia solanacearum

Q8Y303
Q06210

470
FNDDIQGTA

Pseudomonas aeruginosa,

Q9HYD5, Q02QW0,
Q16798

Pseudomonas aeruginosa,

B7UWK9, A6V1V5

Pseudomonas aeruginosa,

Pseudomonas aeruginosa

471
FNDDIQGTASVAV

Pseudomonas savastanoi,

Q48LC8, Q4ZW63,
Q16798

Pseudomonas syringae,

Q87Y79

Pseudomonas syringae

472
FPAGILQAPFY

Lactobacillus helveticus

O52071
Q60344

473
FPGYTHLQRAQPI

Bacillus pumilus

A8FG69
P04424

474
FPHHENEIAQ

Corynebacterium kropnstedtii,

C4LH17, Q82GD0,
Q9HA77

Streptomyces avermitilis,

B1VS94, Q9L0Q6

Streptomyces griseus, Streptomyces

coelicolor

475
FPLLTTKRV

Bacillus cytotoxicus, Bacillus

A7GP90, Q6HJC7,
P04818

thuringiensis, Bacillus thuringiensis,

A0RDL9, Q81R23,

Bacillus anthracis, Bacillus cereus,

Q81E05, Q738X7,

Bacillus cereus, Bacillus cereus,

Q63BV5, Q834R3,

Enterococcus faecalis, Pediococcus

Q03F96

ntosaceus

476
FPLWWQTGSGT

Bacillus subtilis, Methylobacterium

P07343, Q8KTE1,
P07954

Q

extorquens, Neisseria meningitidis,

Q9JTR0, Q885V0,

Pseudomonas syringae,

Q88M20, Q8X0E8

Pseudomonas putida, Ralstonia

solanacearum

477
FQALRIFVN

Rhizobium etli, Rhizobium

Q2K6B3, Q1ME25,
A6NJ78

leguminosarum, Rhizobium sp.,
C3MEN7, B3PTW8,

Rhizobium etli, Rhizobium meliloti,

Q92NL4, B5ZWK2,

Rhizobium leguminosarum,

C6ARU7

Rhizobium leguminosarum

478
FRASPRQSD

Helicobacter hepaticus

Q7VFS3
O75251

479
FRASPRQSDVMI

Helicobacter pylori, Helicobacter

B6JNA1, B5Z8Q6,
O75251

pylori, Helicobacter acinonychis,

Q17Z53, O25851,

Helicobacter pylori, Helicobacter

B2UV25, Q1CS00,

pylori, Helicobacter pylori,

Q9ZJW6

Helicobacter pylori

480
FRPWTIRQYAGFS

Propionibacterium freudenreichii

P11653
P22033

T

481
FSMCEHHLVPF

Bacillus halodurans

Q9KCC7
P30793

482
FSMDGDIAPL

Escherichia coli, Ralstonia pickettii,

B7LC58, B2UBJ3,
Q75600

Ralstonia solanacearum,

Q8XZC3, B2FLM5,

Stenotrophomonas maltophilia,

B4SM82

Stenotrophomonas maltophilia

483
FTFGPTFRAE

Lactobacillus plantarum, Lactobacillus

Q88Y40, A8YVJ7,
Q96159

helveticus, Lactobacillus delbrueckii,

P54262, Q74JA9,

Lactobacillus johnsonii, Lactobacillus

Q043G9

gasseri

484
FTSGATESNN

Aeromonas salmonicida, Neisseria

A4SP14, Q9JYY0
Q9Y697

meningitidis

485
FTSGGTESN

Bacillus subtilis

P38033
Q96115

486
FTSGGTESNN

Lactobacillus delbrueckii, Rhizobium

P31672, P55690
Q96115

sp.

487
FTTWADTGDF

Pseudomonas syringae,

Q884H4, Q4ZV64,
P37837

Pseudomonas syringae,

Q48KH5

Pseudomonas savastanoi

488
FVCLGNICRSP

Staphylococcus haemolyticus,

Q4L7J1, Q6GFH6,
P24666

Staphylococcus aureus,

Q49Y56, Q6G853,

Staphylococcus saprophyticus,

Q7A0I2, Q2FX12,

Staphylococcus aureus,

P0Q5D2, Q7A4S1,

Staphylococcus aureus,

Q5HEP3, Q99T00,

Staphylococcus aureus,

Q2FFL4, Q2YU46,

Staphylococcus aureus,

Q8CNQ1, Q5HN53

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

489
FVPNDMQVGQTG

Pseudomonas aeruginosa

Q9HZP7
P13804

KIVAP

490
FWVGPEAPL

Rhizobium meliloti

Q92RL0
P22102

491
FYAAVEMRDNP

Aeromonas hydrophila, Citrobacter

A0KHD5, A8AKQ2
Q9UBT6

koseri

492
FYDGPPFATGLPH

Pseudomonas fluorescens

Q8L1B1
P41252

YGHIL

493
FYGPFRDAA

Bacillus subtilis, Bacillus halodurans

P30950, Q9K8G2
P13716

494
FYQASTSELYG

Rhizobium fredii, Rhizobium sp.
O85713, P55354
Q60547

495
GACVNAPMV

Rhizobium meliloti

P56909
P19404

496
GAFTGEISP

Bacillus licheniformis, Bacillus subtilis,

Q65EN0, P27876,
P60174

Bacillus halodurans, Listeria innocua,

Q9K715, Q928I1,

Listeria monocytogenes, Listeria

Q71WW9, Q8Y4I3

monocytogenes

497
GAFTGEISPGM

Geobacter metallireducens

Q39U97
P60174

498
GAFYGPKIDI

Helicobacter hepaticus

Q7VJO9
P26639

499
GAFYGPKIDIKI

Campylobacter lari

B9KEB1
A2RTX5

500
GAGDQGLMFG

Lactobacillus sakei, Lactobacillus

Q38YF8, B2GDG2,
Q00266

fermentum, Lactobacillus helveticus,

A8YWU7, Q5FIN8,

Lactobacillus acidophilus,

Q74K54, Q837P9,

Lactobacillus johnsonii, Enterococcus

C6E2L2, B8DFQ7,

faecalis, Geobacter sp., Listeria
Q71Z03, C1KVW3,

monocytogenes, Listeria

Q8Y6M0, Q92AZ5,

monocytogenes, Listeria

A0AJB9, Q98A80,

monocytogenes, Listeria

B9DN19, A3CNY4,

monocytogenes, Listeria innocua,

Q8DT23, Q5LZI0,

Listeria welshimeri, Rhizobium loti,

A8AWW6, Q5M434,

Staphylococcus carnosus,

A4W351, A4VWU8,

Streptococcus sanguinis,

COM9M7, B4U228,

Streptococcus mutans, Streptococcus

C0MCM1, B9DSM6,

thermophilus, Streptococcus gordonii,

Q8DQH0, B2INE5,

Streptococcus thermophilus,

B1IAT8, B5E364,

Streptococcus suis, Streptococcus

Q04LE0, B8ZNB7,

suis, Streptococcus equi,

Q8E5Y0, C1C6A5,

Streptococcus equi, Streptococcus

C1CJL0, B5XM14,

equi, Streptococcus uberis,

A2RE06, Q1JL80,

Streptococcus pneumoniae,

Q1JB36, Q8P0G6,

Streptococcus pneumoniae,

P0DF55, P0DF54,

Streptococcus pneumoniae,

Q5XBJ6, Q485U7,

Streptococcus pneumoniae,

C1CQM2, Q97RN9,

Streptococcus pneumoniae,

Q8E0A3, Q3K1M7,

Streptococcus pneumoniae,

Q99Z77, Q1J626,

Streptococcus agalactiae,

C1CDB0, Q1JGA1

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pyogenes

501
GAGDQGLMFGYA

Acinetobacter baylyi, Acinetobacter

Q6FA06, B0VC98,
Q00266

baumannii, Acinetobacter baumannii,

A3M4V2, B0VR30,

Acinetobacter baumannii,

B2HYY9, Q03QA4,

Acinetobacter baumannii,

A5GA66, Q39W48,

Lactobacillus brevis, Geobacter

P61946, AIK598,

uraniireducens, Geobacter

A9M1V8, Q9JW6,

metallireducens, Geobacter

Q9JY09, Q5FAC0,

sulfurreducens, Neisseria

B4R036, Q8Y347,

meningitidis, Neisseria meningitidis,

B2UD22, Q9X4Q2

Neisseria meningitidis, Neisseria

meningitidis, Neisseria gonorrhoeae,

Neisseria gonorrhoeae, Ralstonia

solanacearum, Ralstonia pickettii,

Streptomyces sctabilis

502
GAGDQGLMFGYA

Pediococcus ntosaceus,

Q03GG8, Q8NVZ9,
Q00266

T

Staphylococcus aureus,

A8Z4L2, Q2G1W4,

Staphylococcus aureus,

Q6G8E3, A6QHX0,

Staphylococcus aureus,

Q5HEY9, Q2YTK1,

Staphylococcus aureus,

Q2FFV6, P50307,

Staphylococcus aureus,

P66767, P66766,

Staphylococcus aureus,

A5ITV6, A6U2Q1,

Staphylococcus aureus,

A7X3N2, Q6GFR6,

Staphylococcus aureus,

Q4L7C7, Q49YL6

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus saprophyticus

503
GAGDQGLMFGYA

Lactobacillus reuteri, Lactobacillus

B2G8G3, A5VL29,
Q00266

TDET

reuteri, Staphylococcus epidermidis,

Q8CNT5, Q5HNB8,

Staphylococcus epidermidis,

Q827Q0

Streptomyces avermitilis

504
GAGGQHVNKT

Methylobacterium sp.,
B0UAV4, B8IUB4,
Q75570

Methylobacterium nodulans,

A9W1A4, B7L246,

Methylobacterium extorquens,

B1Z914, B1M766

Methylobacterium extorquens,

Methylobacterium populi,

Methylobacterium radiotolerans

505
GAGGQHVNKTDS

Pseudomonas stutzeri

A4VPB9
Q75570

A

506
GAGHFVKMVHNG

Bacillus licheniformis

P52207
P52209

1EY

507
GAGISTESGIPDY

Streptomyces coelicolor

Q9RL35
Q9Y6E7

R

508
GAGKTTVGR

Acinetobacter baumannii,

B0V8M8, B0V033,
Q81Y07

Acinetobacter baumannii,

Q6F7E4, Q8XV61,

Acinetobacter baylyi, Ralstonia

A8AXY8

solanacearum, Streptococcus

gordonii

509
GAGVSAESG

Pseudomonas aeruginosa

Q9I4L0
Q9NXA8

510
GAGVSAESGVPT

Ralstonia solanacearum

Q8Y015
Q9NXA8

FR

511
GAHIYVCGDA

Neisseria meningitidis, Neisseria

A1KU06, Q9JUD8,
P16435

meningitidis, Neisseria meningitidis,

A9LZ73, Q9J545

Neisseria meningitidis

512
GAHTDSPCLRVK

Pseudomonas stutzeri, Pseudomonas

A4VJG1, A4XRN0,
Q9ULA0

mendocina, Pseudomonas syringae,

Q4ZW15, C3K0D7,

Pseudomonas fluorescens,

Q48L80, Q87YC5,

Pseudomonas savastanoi,

Q3KFM3, Q02Q78,

Pseudomonas syringae,

B0KTU0, A6V2H4,

Pseudomonas fluorescens,

Q1IDE6, Q9HYZ3,

Pseudomonas aeruginosa,

B7V7X2, B1J1S3,

Pseudomonas putida, Pseudomonas

Q88M44, A5W7K3

aeruginosa, Pseudomonas

entomophila, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

putida

513
GAHVNPAVT

Haemophilus influenzae

O86231
P30301

514
GANAILGVS

Enterococcus faecalis, Enterococcus

E6ER18, P0DM31,
P06733

faecalis, Enterococcus hirae,

Q8GR70, Q8DT59,

Streptococcus mutans, Streptococcus

B9DRR9, Q1JML5,

uberis, Streptococcus pyogenes,

Q1JCN8, B5XKM7,

Streptococcus pyogenes,

P0DA95, Q48UF7,

Streptococcus pyogenes,

A2RFE3, Q1J7I5,

Streptococcus pyogenes,

P69951, Q1JHQ6,

Streptococcus pyogenes,

P0DA94, P69949,

Streptococcus pyogenes,

Q5XD01, P64081,

Streptococcus pyogenes,

Q3K2B2, P64080,

Streptococcus pyogenes,

A4W2T1, C0MH89,

Streptococcus pyogenes,

B4U2B8, C0M6K5,

Streptococcus pyogenes,

C1CRM6, C1CKJ0,

Streptococcus pyogenes,

C10EB3, Q97QS2,

Streptococcus pyogenes,

B8ZPW9, B1IBR3,

Streptococcus agalactiae,

C1C7C0, B5E4P1,

Streptococcus agalactiae,

A3CMA7, Q8DPS0,

Streptococcus agalactiae,

B2IPX8, Q04KG2

Streptococcus suis, Streptococcus

equi, Streptococcus equi,

Streptococcus equi, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

sanguinis, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae

515
GANAILGVSLA

Bifidobacterium longum,

B3DSV2, Q8G5I9
P06733

Bifidobacterium longum

516
GAPGSGKGT

Porphyromonas gingivalis,

Q7MW54, B2RIY8
Q9UIJ7

Porphyromonas gingivalis

517
GAPNAGKSTL

Rhizobium loti

Q985A5
Q75616

518
GAPPHGGIA

Propionibacterium acnes

Q6A8J1
Q6PI48

519
GAQWGDEGKGK

Bifidobacterium longum,

Q8G6T9, B3DNT3,
Q8N142

Bifidobacterium longum,

B7GT29, A0ZZG5,

Bifidobacterium longum,

Q9RHX5, B0UJ78,

Bifidobacterium adolescentis,

B8DVC2, Q8FMB0,

Corynebacterium ammoniagenes,

Q6NF38, Q8NM16,

Methylobacterium sp., Bifidobacterium
A4QHG2, C3PJK0,

animalis, Corynebacterium efficiens,

Q4JXT3, B1VHT9,

Corynebacterium diphtheriae,

Q31769, B8DQ18,

Corynebacterium glutamicum,

A1V9U1, Q725K9,

Corynebacterium glutamicum,

B8J4N1, B2GL12,

Corynebacterium aurimucosum,

B1M1K0, B7L289,

Corynebacterium jeikeium,

B1Z962, B8IPM5,

Corynebacterium urealyticum,

C5C8H9, A5VFF3

Desulfovibrio alaskensis,

Desulfovibrio vulgaris, Desulfovibrio

vulgaris, Desulfovibrio vulgaris,

Desulfovibrio desulfuricans, Kocuria

rhizophila, Methylobacterium

radiotolerans, Methylobacterium

extorquens, Methylobacterium populi,

Methylobacterium nodulans,

Micrococcus luteus, Sphingomonas

wittichii

520
GAQWGDEGKGK

Geobacter sulfurreducens, Geobacter

Q747F9, Q39QK1,
Q8N142

VVD

metallireducens, Geobacter daltonii,

B9M1R2, A5GC19,

Geobacter uraniireducens, Geobacter

B3EAS4, C6DZQ7,

lovleyi, Geobacter sp., Geobacter
B5ECF3

bemidjiensis

521
GASGDLAPL

Clostridium tetani, Streptococcus

Q891Q1, A3CL24,
P42357

sanguinis, Streptococcus gordonii,

A8AZ70, A2RGS5,

Streptococcus pyogenes,

Q8NZ46, Q5X9K4,

Streptococcus pyogenes,

B5XIY2, P58083,

Streptococcus pyogenes,

P0DB75, P0DB74

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

522
GASGDLAPLSH

Streptomyces globisporus

Q8GMG0
P42357

523
GASGDLAPLSHLA

Bacillus clausii, Bacillus subtilis,

Q5WAZ6, P10944,
P42357

L

Staphylococcus saprophyticus

Q4A173

524
GAVKITPAHD

Bacillus licheniformis, Bacillus

Q65GK8, Q9K8G8,
P26640

halodurans, Bacillus subtilis, Bacillus

Q05873, Q5WEQ4,

clausii, Listeria innocua, Listeria

Q92BG2, Q8Y6X9,

monocytogenes, Listeria

Q71ZB6

monocytogenes

525
GCCPGGTASN

Bacillus subtilis

O34524
Q12908

526
GCFWGAERKFW

Methylobacterium sp.,
B0UCG5, B8IJD1,
Q9UJ68

Methylobacterium nodulans,

B1W2P8

Streptomyces griseus

527
GCIPSKALL

Bacillus subtilis

P54533
P09622

528
GCMKGRTMYVIPF

Clostridium thermocellum

A3DJE3
P35558

SMGP

529
GCMKGRTMYVIPF

Geobacter sulfurreducens

Q746Y3
P35558

SMGPLGSP

530
GDADVMVAGG

Escherichia coli, Escherichia coli,

P0AAI5, P0AAI6,
Q9NUVU1

Escherichia coli

P0AAI7

531
GDADVMVAGGT

Rhizobium meliloti

P56902
Q9NUVU1

532
GDDEAMFID

Parabacteroides distasonis

A6L8C6
Q15046

533
GDGAANQGQ

Rhizobium meliloti

Q9R9N5
P08559

534
GDGAFYGPKID

Bacillus subtilis, ptoclostridium

P18256, Q18968,
A2RTX5

difficile, Clostridium thermocellum,

A3DET1, Q891T0,

Clostridium tetani, Clostridium

B1IMV3, B1L0T7,

botulinum, Clostridium botulinum,

C3KTK0, A5I6L8,

Clostridium botulinum, Clostridium

A7FY87, C1FKN0,

botulinum, Clostridium botulinum,

A7GI05, A5N258,

Clostridium botulinum, Clostridium

B9E5W0, A0PZN1,

botulinum, Clostridium kluyveri,

B8J4E4, Q30Y11,

Clostridium kluyveri, Clostridium

A1VBB4, Q728R5

novyi, Desulfovibrio desulfuricans,

Desulfovibrio alaskensis,

Desulfovibrio vulgaris, Desulfovibrio

vulgaris

535
GDGAFYGPKIDI

Desulfovibrio salexigens

C6BRH1
A2RTX5

536
GDGAFYGPKIDIK

Desulfovibrio maeticus, Desulfovibrio

C4XL11, B8DPN2,
A2RTX5

vulgaris, Geobacter bemidjiensis,

B5EBX9, C6DYJ5,

Geobacter sp., Geobacter
Q74D04

sulfurreducens

537
GDGIARVHG

Desulfovibrio vulgaris, Desulfovibrio

Q72E02, AlVFJ3
P25705

vulgaris

538
GDGIARVHGL

Bacillus pumilus, Bacillus

A8FIB4, Q65DX2,
P25705

licheniformis, Bacillus

A7Z9Q2, P37808,

methylotrophicus, Bacillus subtilis,

B8FZ36, Q24MN9

Desulfitobacterium hafniense,

Desulfitobacterium hafniense

539
GDGIGPEIS

Bacteroides thetaiotaomicron,

Q8A6M0, P54354,
P50213

Bacteroides fragilis, Bacteroides

Q5LAB4

fragilis

540
GDGVNDAPAL

Bacillus pseudofirmus, Listeria

P30336, P58414,
Q14983

monocytogenes, Rhizobium

Q9X5V3, Q4A0G1,

leguminosarum, Staphylococcus

P20021, Q6GIX1,

saprophyticus, Staphylococcus

P37386

aureus, Staphylococcus aureus,

Staphylococcus aureus

541
GDIIIDGGN

Citrobacter amalonaticus, Citrobacter

P41581, P41582,
P52209

koseri, Citrobacter freundii,

P41583, P00350,

Escherichia coli, Escherichia coli,

P37754, P41574,

Escherichia vulneris, Klebsiella

P41576, P41577,

pneumoniae, Raoultella terrigena,

P41575

Raoultella planticola

542
GDMDFKIAGT

Desulfovibrio alaskensis,

Q30WI5, B8J1X9
Q8TCS8

Desulfovibrio desulfuricans

543
GDRVAIYMP

Streptomyces coelicolor

Q9X928
Q9NUB1

544
GDRVAVMLP

Bacillus subtilis

P94547
Q68CK6

545
GDVLVLTKPLGT

Eubacterium acidaminophilum

Q9L473
P49903

546
GDWKGYTGK

Haemophilus ducreyi

Q7VNR9
P06744

547
GEEQVKIWRRS

Clostridium phytofermentans

A9KNQ1
P15259

548
GEERCIACKLCEA

Neisseria meningitidis, Neisseria

Q7DDS1, A1KRT1,
O00217

meningitidis, Neisseria gonorrhoeae,

Q5F623, Q9JQM2,

Neisseria meningitidis, Ralstonia

Q8XXQ9

solanacearum

549
GEIVSADSMQ

Leuconostoc mesenteroides

Q03VI2
Q9H3H1

550
GENGAGKST

Clostridium tetani

Q89712
Q9NUQ8

551
GEPVSAEDL

Proteus mirabilis

B4ET09
P11586

552
GERAYDIYSRLL

Lactobacillus salivarius, Haemophilus

Q1WTA8, B8F822
Q16740

parasuis

553
GEVMAIGRT

Bacillus subtilis, Lactobacillus

P25994, A8YVZ3,
P31327

helveticus, Lactobacillus delbrueckii,

Q047M8, Q5FJC0,

Lactobacillus acidophilus,

Q74J34, B2GD06,

Lactobacillus johnsonii, Lactobacillus

Q038Z2, B3WEF5,

fermentum, Lactobacillus casei,

B2G564, A5VHN6,

Lactobacillus casei, Lactobacillus

Q8RG86, Q4L5Q5,

reuteri, Lactobacillus reuteri,

P63739, P63740,

Fusobacterium nucleatum,

A6U122, A7X1F4,

Staphylococcus haemolyticus,

A5Is88, Q2FHN5,

Staphylococcus aureus,

A8Z3P0, Q5HGM9,

Staphylococcus aureus,

A6QGA4, Q2FZ72,

Staphylococcus aureus,

Q6GA10, Q5HPY8,

Staphylococcus aureus,

Q8CPJ4, Q6GHN2,

Staphylococcus aureus,

Q2YXG5, P58940,

Staphylococcus aureus,

Q49WY4, B9DRV7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Streptococcus uberis

554
GEVMAIGRTFEES

Bacillus caldolyticus

P46537
P31327

555
GEVTEINEA

Methylobacterium nodulans

B8IU03
P23434

556
GFCHGVLNTDNM

Aeromonas salmonicida

A4SHK8
Q9BVL4

S

557
GFILDGFPR

Lactobacillus johnsonii, Lactobacillus

Q74L69, Q046A5,
Q5TCS8

gasseri, Lactobacillus delbrueckii,

Q04BZ4, B5EFS1,

Geobacter bemidjiensis, Geobacter

C6E4N6

sp.

558
GFLLDGFPRTV

Bacillus methylotrophicus, Bacillus

A7Z0Q9, P16304
P54819

subtilis

559
GFPGETDQDF

Haemophilus somnus, Rhizobium

Q0I3Z1, Q92SI7
Q5W42

meliloti

560
GFPSVGKST

Lactobacillus delbrueckii,

Q04611, Q1GAM3,
P55039

Lactobacillus delbrueckii,

Q03F34

Pediococcus ntosaceus

561
GFPSVGKSTLLS

Lactobacillus reuteri, Lactobacillus

B2G6R9, A5VJ99,
Q9Y295

reuteri, Lactobacillus fermentum

B2GBD0

562
GFRGEALASI

Lactobacillus delbrueckii,

Q1G939, Q048Y5,
P40692

Lactobacillus delbrueckii,

Q74KW0, Q035Z3,

Lactobacillus johnsonii, Lactobacillus

B3W9W3, Q045Q4,

casei, Lactobacillus casei,

Q8XWB1, B1H0C7

Lactobacillus gasseri, Ralstonia

solanacearum, Uncultured termite

563
GFRGEALASIS

Aeromonas hydrophila, Aeromonas

A0KGR9, A45R27,
P40692

salmonicida, Lactobacillus

Q5FLX4, A8YTI0,

acidophilus, Lactobacillus helveticus,

A8AMN1, C3KX34,

Citrobacter koseri, Clostridium

B1IM67, A7FUK9,

botulinum, Clostridium botulinum,

A7GE44, B1KSA2,

Clostridium botulinum, Clostridium

C1FNT8, C5BDM9,

botulinum, Clostridium botulinum,

A4W5R1, A1AJ76,

Clostridium botulinum, Edwardsiella

Q0T9M3, B7MKX4,

ictaluri, Enterobacter sp., Escherichia
P23367, B1XDS1,

coli, Escherichia coli, Escherichia coli,

C5A1G1, B6I274,

Escherichia coli, Escherichia coli,

A8A7R4, B7UQH9,

Escherichia coli, Escherichia coli,

A7ZV39, B7M8T0,

Escherichia coli, Escherichia coli,

Q8XDN4, B1LQJ0,

Escherichia coli, Escherichia coli,

B5Z2H6, B7MSY3,

Escherichia coli, Escherichia coli,

Q8FAK9, B1IT36,

Escherichia coli, Escherichia coli,

B7LLV2, B7LC24,

Escherichia coli, Escherichia coli,

B7NGA4, A5UB71,

Escherichia fergusonii, Escherichia

A5UFN4, Q4QPH7,

coli, Escherichia coli, Haemophilus

P44494, Q7VN43,

influenzae, Haemophilus influenzae,

Q0I463, B5Y334,

Haemophilus influenzae,

A6TH85, B4F203,

Haemophilus influenzae,

A4VQP2, B0KKZ7,

Haemophilus ducreyi, Haemophilus

C3KDW1, Q1I447,

somnus, Klebsiella pneumoniae,

B1JAD6, B7V209,

Klebsiella pneumoniae, Proteus

Q9HUL8, Q02F72,

mirabilis, Pseudomonas stutzeri,

Q88DD1, Q87VJ2,

Pseudomonas putida, Pseudomonas

A6VD59, B9DPC0,

fluorescens, Pseudomonas

Q49X89, Q6GHD9,

entomophila, Pseudomonas putida,

P65492, P65491,

Pseudomonas aeruginosa,

A7X1T8, A6U1B5,

Pseudomonas aeruginosa,

Q8NWX9, Q6G9R7,

Pseudomonas aeruginosa,

A8Z1W7, Q5HGD5,

Pseudomonas putida, Pseudomonas

A6QGJ5, Q93T05,

syringae, Pseudomonas aeruginosa,

Q2FHE2, Q8CPE9,

Staphylococcus carnosus,

Q5HPP4

Staphylococcus saprophyticus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

564
GFRGEALSS

Eubacterium rectale

C4ZA52
P54278

565
GFVMGEGAAVLV

Streptomyces coelicolor

P23155
Q9NWU1

LE

566
GFYSAFMVA

Bacteroides thetaiotaomicron

Q8A9B8
Q12931

567
GGADRIELCS

Rhizobium meliloti

Q925Z1
Q9NTM9

568
GGAGVQHIAL

Streptomyces avermitilis,

Q53586, Q9S2F4
P32754

Streptomyces coelicolor

569
GGAGYIGSH

Lactobacillus helveticus,

Q7WTB1, P96995,
Q14376

Streptococcus mutans, Streptococcus

P21977

thermophilus

570
GGAGYIGSHT

Rhizobium leguminosarum,

Q59745, P26503
Q14376

Rhizobium meliloti

571
GGAGYIGSHTV

Lactobacillus casei

O84903
Q14376

572
GGAIALGHP

Bacillus subtilis, Clostridium

P45855, P45359,
Q9BWD1

acetobutylicum, Escherichia coli,

Q46939, Q9I2A8,

Pseudomonas aeruginosa,

P28790, Q87ZB3,

Pseudomonas fragi, Pseudomonas

Q3K9D9, Q4ZRA1,

syringae, Pseudomonas fluorescens,

Q4KFC3, Q48GW4,

Pseudomonas syringae,

Q02PH7, A6V383,

Pseudomonas fluorescens,

Q9HZJ3, A5W6G9,

Pseudomonas savastanoi,

Q93Q11, Q9R9W0,

Pseudomonas aeruginosa,

Q88L01, Q1I7D5,

Pseudomonas aeruginosa,

A4XSM9, A4VKA4

Pseudomonas aeruginosa,

Pseudomonas putida, Pseudomonas

oleovorans, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas

mendocina, Pseudomonas stutzeri

573
GGAIALGHPLG

Acinetobacter baumannii,

A3M1H9, B7I3P0,
Q9BWD1

Acinetobacter baumannii,

B0VLX5, B0VE46,

Acinetobacter baumannii,

B7H1I1, B2I2J8,

Acinetobacter baumannii,

Q6FF69, A0KEL0,

Acinetobacter baumannii,

A4STF3, O32177,

Acinetobacter baumannii,

A8ACZ3, A4WFX5,

Acinetobacter baylyi, Aeromonas

Q9F0Y6, P0C7L3,

hydrophila, Aeromonas salmonicida,

P0C7L2, B7LTZ0,

Bacillus subtilis, Citrobacter koseri,

Q8X8J4, A1A132,

Enterobacter sp., Enterobacter
A8A6V0, A7ZU50,

cloacae, Escherichia coli, Escherichia

Q1R467, Q8FBI3,

coli, Escherichia fergusonii,

P21151, Q0TAL1,

Escherichia coli, Escherichia coli,

A6TGM3, Q9I6R0,

Escherichia coli, Escherichia coli,

Q51956

Escherichia coli, Escherichia coli,

Escherichia coli, Escherichia coli,

Klebsiella pneumoniae,

Pseudomonas aeruginosa,

Pseudomonas putida

574
GGAIALGHPLGAS

Pseudomonas knackmussii

Q8VPF1
Q9BWD1

G

575
GGARGQATDI

Clostridium thermocellum, Clostridium

A3DJ10, B8I8F5
Q16740

cellulolyticum

576
GGDGTLLYA

Bacillus licheniformis, Bacillus cereus,

Q65LA2, Q81GJ9,
O95544

Bacillus thuringiensis, Bacillus cereus,

Q6HLY2, Q63EG5,

Bacillus anthracis, Bacillus cereus,

Q81TQ3, Q73BU7,

Bacillus subtilis

O31612

577
GGENIYPAE

Bacillus licheniformis, Bacillus

Q65FT5, A8FGK6,
Q96CM8

pumilus, Bacillus subtilis, Bacillus

P23971, A7Z809

methylotrophicus

578
GGFGLCGIPE

Bacillus subtilis

P42315
P55809

579
GGGCSGFQY

Aeromonas salmonicida, Aeromonas

A4SJ82, A0KNY6,
Q86U28

hydrophila, Citrobacter koseri,

A8ALD2, C5BAP7,

Edwardsiella ictaluri, Enterobacter

A4W6Q3, B7LWB7,

sp., Escherichia fergusonii,
Q1RG32, B1LGV9,

Escherichia coli, Escherichia coli,

B6HZD2, B7N825,

Escherichia coli, Escherichia coli,

P0ACC3, B1IQI4,

Escherichia coli, Escherichia coli,

P0ACC4, A1A7K2,

Escherichia coli, Escherichia coli,

A7ZWA4, Q0TLH5,

Escherichia coli, Escherichia coli,

B1XD26, B7M197,

Escherichia coli, Escherichia coli,

C4ZRP9, B7NIB9,

Escherichia coli, Escherichia coli,

B7MP18, B5Z0D6,

Escherichia coli, Escherichia coli,

P0ACC5, B7MBD9,

Escherichia coli, Escherichia coli,

B7LGL8, B7UIK3,

Escherichia coli, Escherichia coli,

A7ZHP8, Q0I3N9,

Escherichia coli, Haemophilus

P45344, A5UBF7,

somnus, Haemophilus influenzae,

A5UFF5, Q4QJM4,

Haemophilus influenzae,

Q9X4A0, B8F870,

Haemophilus influenzae,

A6T4W0, B5Y1L3,

Haemophilus influenzae,

Q7DDN1, A1KSG6,

Haemophilus ducreyi, Haemophilus

A1IQG0, Q5F6W8,

parasuis, Klebsiella pneumoniae,

B4EUE2, Q88QQ5,

Klebsiella pneumoniae, Neisseria

Q4K514, Q1IFY7,

meningitidis, Neisseria meningitidis,

Q4ZMM4, Q889Z2,

Neisseria meningitidis, Neisseria

Q48NN6, Q3K5W6,

gonorrhoeae, Proteus mirabilis,

C3K2Z6, A4XZB1,

Pseudomonas putida, Pseudomonas

A4VHK9, B7V623,

fluorescens, Pseudomonas

Q02TA1, Q9I5Q6,

entomophila, Pseudomonas syringae,

A6UZG6, B2UFK5,

Pseudomonas syringae,

Q8Y242

Pseudomonas savastanoi,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas mendocina,

Pseudomonas stutzeri, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Ralstonia pickettii,

Ralstonia solanacearum

580
GGGSIRIHNA

Staphylococcus carnosus

B9DNF8
Q6PI48

581
GGIDILVNNAS

Rhizobium loti

Q988B7
Q6YN16

582
GGILDDLIV

Streptomyces coelicolor,

O86567, Q82JI2
P48728

Streptomyces avermitilis

583
GGKPANFLD

Campylobacter fetus, Haemophilus

A0RPE8, A5UCR4,
Q96I99

influenzae, Haemophilus influenzae,

P45101, A5UIW0,

Haemophilus influenzae,

Q4QLA3, Q4KFY6,

Haemophilus influenzae,

Q883Z4, Q4ZUW7,

Pseudomonas fluorescens,

Q48K68, Q3KFU6,

Pseudomonas syringae,

C3K6N0, P53593,

Pseudomonas syringae,

B7UVD3, A6V7K5,

Pseudomonas savastanoi,

Q02K73, B1JAV3,

Pseudomonas fluorescens,

Q1I7L3, Q88FB2,

Pseudomonas fluorescens,

A5W114, B0KNW8

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

putida

584
GGLRTALYNY

Campylobacter curvus,

A7H0G1, A7ZFB9
Q5JPH6

Campylobacter concisus

585
GGLYPVSAVL

Staphylococcus aureus,

Q6GCU1, Q5HJI8,
P04181

Staphylococcus aureus,

Q8NYM5, P60296,

Staphylococcus aureus,

P60295, Q6GKC1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

586
GGNGWLLDG

Desulfovibrio maeticus

C4XPE9
Q9HC57

587
GGPPCQGFS

Haemophilus parahaemolyticus

P50192
P26358

588
GGREHTLAWK

Bacillus subtilis

P12039
P22102

589
GGRYDGLVG

Acinetobacter baumannii,

A3M212, B2I3E6
P12081

Acinetobacter baumannii

590
GGSAVDAAI

Bacillus anthracis

Q51693
A6NGU5

591
GGSDLGPLMV

Acinetobacter baylyi

Q59088
P06744

592
GGSDLGPLMVT

Acinetobacter lwoffii

Q9RMC1
P06744

593
GGSDNHLIL

Helicobacter hepaticus

Q7VFL1
P34896

594
GGSNGGLLV

Aeromonas hydrophila

Q06903
P48147

595
GGSPTPFDRN

Bacteroides thetaiotaomicron

Q8A2E9
P08237

596
GGSRGIGRA

Escherichia coli

P52037
Q8N4T8

597
GGTCVNVGCVP

Acinetobacter calcoaceticus, Bacillus

Q52109, P16171,
P00390

cereus, Enterobacter agglomerans,

P94702, P00392,

Pseudomonas aeruginosa,

P30341

Streptomyces lividans

598
GGTCVNVGCVPK

Streptococcus thermophilus

Q60151
P00390

KVMW

599
GGTFTISNGGVFG

Pseudomonas aeruginosa

Q9I3D2
P36957

SL

600
GGTVGDIES

Aeromonas hydrophila, Aeromonas

A0KGH2, A4SRC2,
P17812

salmonicida, Bacillus halodurans,

Q9K6D7, Q1WV30,

Lactobacillus salivarius, Bacillus

Q65DT7, P13242,

licheniformis, Bacillus subtilis, Bacillus

A7GV88, Q5W343,

cytotoxicus, Bacillus clausii,

Q88Z76, Q03T27,

Lactobacillus plantarum, Lactobacillus

Q6HAU5, C1F0R6,

brevis, Bacillus thuringiensis, Bacillus

A0RLC3, B7IQZ1,

cereus, Bacillus thuringiensis, Bacillus

Q630R0, B7JHG1,

cereus, Bacillus cereus, Bacillus

Q814T2, C3P2A0,

cereus, Bacillus cereus, Bacillus

C3LFL2, Q81JW1,

anthracis, Bacillus anthracis, Bacillus

Q72XB0, B7HY98,

anthracis, Bacillus cereus, Bacillus

B9IRX1, B7HFN6,

cereus, Bacillus cereus, Bacillus

A9VSD6, A7Z9T4,

cereus, Bacillus weihenstephanensis,

A8FIE5, Q38V48,

Bacillus methylotrophicus, Bacillus

Q74LG2, Q5FME6,

pumilus, Lactobacillus sakei,

Q24MK9, Q8G5X7,

Lactobacillus johnsonii, Lactobacillus

Q5LC42, Q64T27,

acidophilus, Desulfitobacterium

A8ANY8, A3DGR3,

hafniense, Bifidobacterium longum,

A6LQF6, Q97F61,

Bacteroides fragilis, Bacteroides

Q4JVX2, C4LIF4,

fragilis, Citrobacter koseri, Clostridium

C5B8X3, A4WDW8,

thermocellum, Clostridium beijerinckii,

Q836G5, B7UHJ6,

Clostridium acetobutylicum,

Q1R7R3, B1LQB3,

Corynebacterium jeikeium,

B7LWP4, B7LXJ6,

Corynebacterium kropnstedtii,

B7N716, B1XDJ0,

Edwardsiella ictaluri, Enterobacter

B6I6H6, P0A7E7,

sp., Enterococcus faecalis,
P0A7E5, B1IU61,

Escherichia coli, Escherichia coli,

P0A7E6, A8A3R5,

Escherichia coli, Escherichia

B7MLA1, B5Z3E4,

fergusonii, Escherichia coli,

Q0TE79, C4ZZT3,

Escherichia coli, Escherichia coli,

B7NV70, A1AEW8,

Escherichia coli, Escherichia coli,

B7MZ76, B7LEK0,

Escherichia coli, Escherichia coli,

A7ZQM3, Q74BY3,

Escherichia coli, Escherichia coli,

Q39W62, B9M9Q5,

Escherichia coli, Escherichia coli,

A5G5T3, B3EAK5,

Escherichia coli, Escherichia coli,

A5UD28, A5UIK2,

Escherichia coli, Escherichia coli,

Q4QLL2, P44341,

Escherichia coli, Escherichia coli,

Q7VNV5, Q0I200,

Escherichia coli, Geobacter

B8F5Q9, A6TD54,

sulfurreducens, Geobacter

B5XV18, Q927T4,

metallireducens, Geobacter daltonii,

Q71WM0, Q8Y495,

Geobacter uraniireducens, Geobacter

A1KUX8, Q9JTK1,

lovleyi, Haemophilus influenzae,

B4RJ40, Q5F7G6,

Haemophilus influenzae,

Q9JYJ8, A9M0Y3,

Haemophilus influenzae,

Q6A7X4, B4EUF6,

Haemophilus influenzae,

C3K6H4, Q4KHF8,

Haemophilus ducreyi, Haemophilus

B1JBP2, Q3KH94,

somnus, Haemophilus parasuis,

A5W831, Q88MG1,

Klebsiella pneumoniae, Klebsiella

Q1I644, B0KSB7,

pneumoniae, Listeria innocua, Listeria

Q4ZWR0, Q48F77,

monocytogenes, Listeria

Q886M5, B7V7V1,

monocytogenes, Neisseria

Q9HXZ4, A6V1F1,

meningitidis, Neisseria meningitidis,

Q02RA9, A4XWS3,

Neisseria gonorrhoeae, Neisseria

A4VJT9, Q8Y0B8,

gonorrhoeae, Neisseria meningitidis,

B2U9C0, A5V8U1,

Neisseria meningitidis,

C0M8K6, C0MFQ9,

Propionibacterium acnes, Proteus

Q5M6C03 Q5M1S7,

mirabilis, Pseudomonas fluorescens,

Q8NZF8, Q1J4X1,

Pseudomonas fluorescens,

Q1JF16, Q1J9X6,

Pseudomonas putida, Pseudomonas

P0DD70, Q1JK23,

fluorescens, Pseudomonas putida,

Q5XA10, P0DD71,

Pseudomonas putida, Pseudomonas

P65925, Q8DWG1,

entomophila, Pseudomonas putida,

Q97S93, Q48RF1,

Pseudomonas syringae,

Q8DQY0, A3CQB0,

Pseudomonas savastanoi,

A8AZ08, Q8E290,

Pseudomonas syringae,

Q8E7P8, Q3K3S2

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas mendocina,

Pseudomonas stutzeri, Ralstonia

solanacearum, Ralstonia pickettii,

Sphingomonas wittichii,

Streptococcus equi, Streptococcus

equi, Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans, Streptococcus

pneumoniae, Streptococcus

pyogenes, Streptococcus

pneumoniae, Streptococcus

sanguinis, Streptococcus gordonii,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae

601
GHGALAEKA

Clostridium novyi

A0Q0Q1
Q8TCS8

602
GHGALAEKAL

Clostridium acetobutylicum,

Q97I45, Q895J3,
Q8TCS8

Clostridium tetani, Clostridium

A5N848, B9E1K8,

kluyveri, Clostridium kluyveri,

B8DN07, A1VG88,

Desulfovibrio vulgaris, Desulfovibrio

Q72ER6

vulgaris, Desulfovibrio vulgaris

603
GHIAFNEPG

Lactobacillus delbrueckii,

Q047I3, Q1G817,

Lactobacillus delbrueckii,

A8YTN8, Q74HC4,
P46926

Lactobacillus helveticus, Lactobacillus

Q5FHT1

johnsonii, Lactobacillus acidophilus

604
GHLRSTIIG

Bacillus halodurans

Q9KEL8
P54136

605
GHNGAGKST

Aeromonas salmon icida

Q07698
O94911

606
GHNGAGKTT

Pseudomonas stutzeri

P19844
Q8IZY2

607
GHPEVYILILP

Escherichia coli, Escherichia coli,

P0ABI8, P0ABI9,
P00395

Escherichia coli, Pseudomonas

P0ABJ0, Q9I426,

aeruginosa, Pseudomonas putida

Q9WWR2

608
GHPSFVMSNSF

Streptomyces fradiae

P26799
P23526

609
GHSGAGKST

Pseudomonas entomophila,

Q1IGZ0, Q88RL5
O94911

Pseudomonas putida

610
GHSGAGKSTLL

Clostridium acetobutylicum,

Q97KD5, Q18C09,
O94911

ptoclostridium difficile, Pseudomonas

Q4KKK8, Q9HT70,

fluorescens, Pseudomonas

Q02DK6

aeruginosa, Pseudomonas

aeruginosa

611
GHSMGGKTAM

Haemophilus influenzae

Q57427
Q8NFV4

612
GICGSDVHY

Escherichia coli

P77360
Q00796

613
GICLGHQLL

Desulfovibrio maeticus

C4XRH8
P27708

614
GIDLGTTNS

Helicobacter acinonychis,

Q17VY4, Q7VIE3
P38646

Helicobacter hepaticus

615
GIDLGTTNSCV

Campylobacter concisus,

A7ZEB5, A7GXU4,
P38646

Campylobacter curvus, Desulfovibrio

C6BSF2, C3K275,

salexigens, Pseudomonas

Q9WWG9

fluorescens, Pseudomonas

savastanoi

616
GIDLGTTNSCVAV

Haemophilus parasuis, Haemophilus

B8F7S6, A5UF68,
P38646

M

influenzae, Haemophilus influenzae,

P43736, Q4QJW4,

Haemophilus influenzae,

A5UBQ1

Haemophilus influenzae

617
GIGGSDLGP

Propionibacterium acnes,

Q6A5X5, B4SRY7,
P06744

Stenotrophomonas maltophilia,

B2FL71, Q829V7

Stenotrophomonas maltophilia,

Streptomyces avermitilis

618
GIGPVPAIS

Staphylococcus aureus,

Q7A768, Q7A1P9,
P42765

Staphylococcus aureus,

Q7A2W9, Q9KWK4,

Staphylococcus aureus,

Q6GJ93, Q6GBR1,

Staphylococcus aureus,

Q5HIA0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

619
GIIDLKELEAA

Enterobacter sp., Escherichia coli,
A4WDB1, B6I5A2,
Q9Y697

Escherichia coli, Escherichia coli,

P0A6B8, B1LNI6,

Escherichia coli, Escherichia coli,

B7N6B7, B1IWD1,

Escherichia coli, Escherichia coli,

P0A6B7, B1X1305,

Escherichia coli, Escherichia coli,

C4ZXA5, Q0TEV5,

Escherichia coli, Escherichia coli,

A8A336, B7MYG3,

Escherichia coli, Escherichia coli,

B7M7N3, B7NRH9,

Escherichia coli, Escherichia coli,

B5Z104, P0A6B9,

Escherichia coli, Escherichia coli,

B7LDC2, B7MIM0,

Escherichia coli, Escherichia coli,

A7ZPX4, B7UGX6,

Escherichia fergusonii, Klebsiella

B7LKA9, B5XNJ7,

pneumoniae, Klebsiella pneumoniae

A6TCF1

620
GIIVSNHGGRQLD

Pseudomonas mendocina

A4XYG7
Q9NYQ3

621
GILLYGPPG

Bacillus subtilis

O34703
P46459

622
GILVQLPLP

Bacillus cytotoxicus, Bacillus cereus,

A7GSJ9, Q635A3,
Q9H903

Bacillus thuringiensis, Bacillus cereus,

A0RIH3, C1ERQ4,

Bacillus thuringiensis, Bacillus cereus,

Q6HDY4, B7JM32,

Bacillus cereus, Bacillus cereus,

B7HNU4, B9IXH4,

Bacillus cereus, Bacillus cereus,

B7IXH2, Q73162,

Bacillus cereus, Bacillus cereus,

B7HB52, Q818R5,

Bacillus weihenstephanensis, Bacillus

A9VGW3, C3LJV5,

anthracis, Bacillus anthracis, Bacillus

Q81M50, C3P7W0,

anthracis, Enterococcus faecalis,

Q836W7, B0KLM9

Pseudomonas putida

623
GILVQLPLPDH

Campylobacter jejuni

A7H3N3
Q9H903

624
GIMAHIDAGKTTTT

Clostridium botulinum

B2UYA7
Q969S9

ERIL

625
GIMAHIDAGKTTTT

Methylobacterium sp.
B0UHX2
Q969S9

ERILYY

626
GINGFGRIGR

Bacillus megaterium, Bacillus cereus,

P23722, Q4MQ58,
O14556

Haemophilus influenzae, Ralstonia

P44304, P52694,

solanacearum, Streptomyces arenae,

E3VWI2, P54226

Streptomyces arenae

627
GINGFGRIGRL

Lactobacillus delbrueckii

O32755
O14556

628
GINGTVGGS

Corynebacterium jeikeium,

Q4JXR5, B1VHR9
Q5T7W7

Corynebacterium urealyticum

629
GIPFYVAAP

Bacillus weihenstephanensis, Bacillus

A9VFD5, Q731R7,
Q9BV20

cereus, Desulfovibrio salexigens

C6C0F7

630
GIPIAVKDN

Akkermansia muciniphila

B2UMP4
Q9H0R6

631
GISGAIQHLAGM

Bacillus subtilis, Clostridium

P94551, P52039
P13804

acetobutylicum

632
GIVGLPNVGKST

Bacillus subtilis, Escherichia coli,

P37518, P0ABU2,
Q9NTK5

Escherichia coli, Haemophilus

P0ABU3, P44681,

influenzae, Haemophilus ducreyi

Q7VMI2

633
GIVHRDIKP

Streptomyces coelicolor

Q9XA16
Q14164

634
GKAGRNRWLG

Desulfovibrio desulfuricans,

B8IYH5, C6C188,
Q5T653

Desulfovibrio salexigens,

B8DN99

Desulfovibrio vulgaris

635
GKAGRNRWLGKR

Methylobacterium extorquens,

B7L0R4, A9W4Q4
Q5T653

P

Methylobacterium extorquens

636
GKGFQGVMKRW

Desulfovibrio salexigens

C6C185
P09001

637
GKGRPGWHIECS

Staphylococcus carnosus,

B9DKW3, Q5HRM3,
P49589

Staphylococcus epidermidis,

Q8CTU1

Staphylococcus epidermidis

638
GKKVAIIGAG

Escherichia coli

P09832
P31513

639
GKLHTGRSRNDQ

Bacillus methylotrophicus, Bacillus

A7Z7L9, O34858,
P04424

V

subtilis, Bacillus cytotoxicus, Bacillus

A7GTR4, A9VKE0,

weihenstephanensis, Bacillus cereus,

B7IK28, Q6HCP8,

Bacillus thuringiensis, Bacillus

C3L913, Q81KV8,

anthracis, Bacillus anthracis, Bacillus

C3PB96, Q9K821,

anthracis, Bacillus halodurans,

Q633G5, Q817C7,

Bacillus cereus, Bacillus cereus,

B7HRS6, Q72ZA4,

Bacillus cereus, Bacillus cereus,

B7H6Y4, B7JS05,

Bacillus cereus, Bacillus cereus,

A0RJM3, Q5WED9,

Bacillus thuringiensis, Bacillus clausii,

C6BTR8, Q6GIC8,

Desulfovibrio salexigens,

P63582, P63583,

Staphylococcus aureus,

A6QFH1, Q5HHC5,

Staphylococcus aureus,

ASIRD8, A6U067,

Staphylococcus aureus,

Q2FZU2, A7X0H4,

Staphylococcus aureus,

Q8NXF3, Q6GAW6,

Staphylococcus aureus,

Q2YWS5, A8Z066,

Staphylococcus aureus,

Q2FIB5, Q8CT81,

Staphylococcus aureus,

Q5HQK1, B9DIU3,

Staphylococcus aureus,

Q4L4X6

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus carnosus,

Staphylococcus haemolyticus

640
GKLNDHFPLVVW

Rhizobium loti

Q983U5
P07954

QTGSGTQ

641
GKLTARERI

Bacillus subtilis

P54541
P05166

642
GKPDPDIFL

Bacillus subtilis

O06995
Q08623

643
GKRVDFSGR

Campylobacter fetus, Campylobacter

A0RQI4, B9KFG8,
O14802

lari, Campylobacter jejuni,

A8FKR4, A1VYJ5,

Campylobacter jejuni, Campylobacter

Q5HVY8, Q9PI30,

jejuni, Campylobacter jejuni,

B2UUV9, Q17VN6,

Helicobacter pylori, Helicobacter

Q25806, Q1CS68,

acinonychis, Helicobacter pylori,

Q9ZK23

Helicobacter pylori, Helicobacter

pylori

644
GKSTLINTL

Helicobacter hepaticus

Q7VGJ2
Q9UHD8

645
GKSTLLNIL

Pseudomonas aeruginosa,

Q9HX79, Q02SA6,
Q94911

Pseudomonas aeruginosa,

Q4L8L7

Staphylococcus haemolyticus

646
GKSTLMNIL

Acinetobacter baylyi, Campylobacter

Q6F813, A0RP01,
P45844

fetus, Escherichia coli, Escherichia

Q0TJH0, Q1RE44,

coli, Escherichia coli, Escherichia coli,

A1A9B7, P75831,

Escherichia coli, Neisseria

Q8XED0, Q5MK06,

gonorrhoeae, Neisseria gonorrhoeae,

Q5F6V6, Q9K0N7,

Neisseria meningitidis, Neisseria

Q9JVR5, Q91I90,

meningitidis, Pseudomonas

Q02MI4, Q1I966,

aeruginosa, Pseudomonas

Q3KE48, Q4KES7,

aeruginosa, Pseudomonas

Q881Q1, Q88F88,

entomophila, Pseudomonas

Q1I7I9, Q4K9A4,

fluorescens, Pseudomonas

Q92NU9

fluorescens, Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas

fluorescens, Rhizobium meliloti

647
GKSTLVNTL

Rhizobium loti

Q98JM4
Q9UH03

648
GKTALMMAA

Pseudomonas aeruginosa

Q9HYV6
Q8N8A2

649
GKTLAYLLP

Bacillus cereus

Q81E85
Q92841

650
GKTLLAQTLA

Rhizobium loti

Q982V5
O76031

651
GKTNLDEFA

Bifidobacterium longum,

Q8G768, B3DU32,
Q9H0R6

Bifidobacterium longum,

B7GTU6

Bifidobacterium longum

652
GKTNLDEFAMG

Lactobacillus brevis, Clostridium

Q03Q16, B8I601
Q9H0R6

cellulolyticum

653
GKTNLDEFAMGS

Lactobacillus sakei, Lactobacillus

Q38VC9, B2G8T6,
Q9H0R6

reuteri, Lactobacillus reuteri,

A5VLG3, Q6A8P5,

Propionibacterium acnes,

B8J405

Desulfovibrio desulfuricans

654
GKTSIARSIA

Clostridium phytofermentans

A9KH99
P36776

655
GKVADYIPQLA

Rhizobium sp., Rhizobium meliloti
C3MD81, Q92PH0
O94925

656
GKWMDGWETRR

Ralstonia pickettii, Ralstonia

B2UG65, Q8XUB7,
Q8N6M5

solanacearum, Rhizobium meliloti

Q92VC1

657
GKWMDGWETRR

Acinetobacter baumannii,

A3MA02, B0VP26,
Q8N6M5

KR

Acinetobacter baumannii,

B0V9T8, B7GV54,

Acinetobacter baumannii,

B7ICG5, Q6F6Y1,

Acinetobacter baumannii,

A6V7Y9, Q02JZ8,

Acinetobacter baumannii,

B7UW33, Q9I3J8

Acinetobacter baylyi, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa

658
GLAAGKGVI

Staphylococcus aureus,

Q6GI10, Q6GAD9,
P22102

Staphylococcus aureus,

Q5HH10, Q8NX87,

Staphylococcus aureus,

P65895, P65896,

Staphylococcus aureus,

Q5HQ96, Q8CT26

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

659
GLAARDSLRLEAG

Corynebacterium aurimucosum

C3PHK3
P48728

660
GLFDLKAAGF

Methylobacterium sp., Rhizobium
B0UKC4, Q92QW2,
P22102

meliloti, Rhizobium sp., Rhizobium
C3M9F7, Q984K6,

loti, Rhizobium leguminosarum,

Q1MIW9, B3PV93,

Rhizobium etli, Rhizobium

B5ZX12, Q2KA45

leguminosarum, Rhizobium etli

661
GLFDLKAAGFKDP

Methylobacterium nodulans

B8IP71
P22102

662
GLIIGKGGA

Clostridium thermocellum

A3DJH8
P51513

663
GLLGPNGAGK

Escherichia coli, Escherichia coli,

P0A9V1, P0A9V2,
Q8WWZ7

Escherichia coli, Ralstonia

P0A9V3, Q8XXY9,

solanacearum, Rhizobium meliloti

P25885

664
GLLGPNGAGKST

Bacillus subtilis, Escherichia coli,

P94440, P0A9U1,
Q8WWZ7

Rhizobium sp.
P55476

665
GLLGPNGAGKSTI

Rhizobium etli, Rhizobium sp.,
Q8KLG1, P72335,
Q8WWZ7

Rhizobium loti, Rhizobium meliloti,

P23703, O52618,

Rhizobium leguminosarum,

Q1M7W6, Q8GNH6,

Rhizobium meliloti, Rhizobium

P08720, P50332

leguminosarum, Rhizobium galegae

666
GLNKNLGFS

Lactobacillus plantarum

Q88X60
O43252

667
GLNKNLGFSPEDR

Staphylococcus haemolyticus,

Q4L9E6, Q8CR04,
O43252

Staphylococcus epidermidis,

Q5HLO2

Staphylococcus epidermidis

668
GLPNVGKST

Finegoldia magna

B0S3Z4
Q9NTK5

669
GLPSHPQHEL

Pseudomonas aeruginosa

P55218
P32929

670
GLQGSGKTTT

Helicobacter pylori, Helicobacter

P56005, Q9ZK62
P61011

pylori

671
GLQVGDVIL

Pseudomonas putida, Pseudomonas

B1J4D7, B0KV30,
Q86UT5

putida, Pseudomonas putida,

A5W8F5, Q4KGQ4,

Pseudomonas fluorescens,

Q48EU9, F6AA62,

Pseudomonas savastanoi,

A4XSC0

Pseudomonas fulva, Pseudomonas

mendocina

672
GLSKLARIV

Clostridium thermocellum

A3DHH6
P30793

673
GLTAYFGLL

Bacillus subtilis

O34812
Q14914

674
GLTERFELFV

Neisseria meningitidis, Neisseria

A1KUN1, Q9JYU6,
Q15046

meningitidis, Neisseria meningitidis,

Q9JTT7, Q5F6U2,

Neisseria gonorrhoeae, Neisseria

B4RP57

gonorrhoeae

675
GLTGGIASGKS

Bacillus licheniformis, Bacillus

Q65G95, Q6HSG2,
Q8WVC6

anthracis, Bacillus cereus, Bacillus

Q72ZF3, Q6HCU7,

thuringiensis, Bacillus subtilis, Bacillus

Q34932, Q817G7,

cereus, Bacillus cereus, Bacillus

Q633L3, Q5WEG9,

clausii, Lactobacillus johnsonii,

Q74IB6, Q8RHR7,

Fusobacterium nucleatum, Geobacter

Q39R83, Q74FU2,

metallireducens, Geobacter

Q6GG18, Q5HF85,

sulfurreducens, Staphylococcus

Q6G8N8, P63832,

aureus, Staphylococcus aureus,

P63831, Q2FG49,

Staphylococcus aureus,

P63830, Q2YTA2,

Staphylococcus aureus,

Q49Y69, Q3K029,

Staphylococcus aureus,

Q8DYJ2, Q8E449,

Staphylococcus aureus,

Q5M575, Q5M0N9

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus thermophilus,

Streptococcus thermophilus

676
GLTGGIASGKSSV

Bacillus halodurans

Q9K857
Q8WVC6

677
GLVNNAGIST

Streptomyces exfoliatus

P19992
Q02338

678
GMGGAMDLV

Clostridium acetobutylicum,

P23673, P76459,
P55809

Escherichia coli, Haemophilus

P44874

influenzae

679
GMGIPSISI

Lactobacillus sakei, Listeria

Q38X10, A0AJW1,
Q16831

welshimeri, Listeria innocua, Listeria

Q92AF2, Q8Y644,

monocytogenes, Listeria

B8DDP6, Q71YG0,

monocytogenes, Listeria

C1KWF5, A4VWC2,

monocytogenes, Listeria

A4W2M2

monocytogenes, Streptococcus suis,

Streptococcus suis

680
GMNAAVRAV

Lactobacillus delbrueckii,

P80019, Q88VY1,
Q01813

Lactobacillus plantarum, Lactobacillus

B3WE64, Q03910,

casei, Lactobacillus casei,

Q8C568, Q5HNK6

Staphylococcus epidermidis,

Staphylococcus epidermidis

681
GMNAAVRAW

Streptococcus thermophilus,

Q9L9E3, Q03KB7
Q01813

Streptococcus thermophilus

682
GMNAAVRAWR

Staphylococcus aureus,

P65694, Q5HF75,
Q01813

Staphylococcus aureus,

A6QHN3, A8Z2L4,

Staphylococcus aureus,

P65695, Q6G8M8,

Staphylococcus aureus,

P99165, A5ITM2,

Staphylococcus aureus,

Q2FXM8, A6U2G5,

Staphylococcus aureus,

Q2YTE2, Q6GG08,

Staphylococcus aureus,

Q8DTX6

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus mutans

683
GMVITIEPGIY

Staphylococcus epidermidis,

Q8CNW9, Q5HNJ7,
Q9NQH7

Staphylococcus epidermidis,

Q6GFZ9, Q2FXL9,

Staphylococcus aureus,

Q5HF67, Q2FG30,

Staphylococcus aureus,

Q8NW55, Q4L749,

Staphylococcus aureus,

Q99TF5, Q6G8L9,

Staphylococcus aureus,

Q7A552, Q2YTD2

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

684
GMYSALAGF

Pseudomonas syringae,

Q882A9, Q48IH8,
Q86X67

Pseudomonas savastanoi,

Q4ZTN0

Pseudomonas syringae

685
GNLCRCTGY

Bacillus subtilis, Escherichia coli,

Q32143, Q46801,
Q06278

Escherichia coli, Eubacterium barkeri,

Q8X6C4, Q0QLF3,

Pseudomonas sp.
D7REY5

686
GNLNAPTIM

Stenotrophomonas maltophilia

B2FQ89
Q8NE62

687
GNLNAPTIMIAEK

Stenotrophomonas maltophilia

B4SHV9
Q8NE62

688
GNNGGDGLV

Lactobacillus buchneri

F4FTW6
Q8NCVV5

689
GNPRPRVFRL

Methylobacterium nodulans

B8ID11
Q02127

690
GNPRPRVFRLP

Methylobacterium extorquens

B7KZJ5
Q02127

691
GNTGIGLAL

Bacillus subtilis

O05393
P35520

692
GNTVVIKPA

Bacillus subtilis

P42236
O94788

693
GNWDLVGNNTP

Campylobacter jejuni, Haemophilus

Q59296, P44390,
P04040

influenzae, Pseudomonas

O52762, Q49XC1,

aeruginosa, Staphylococcus

Q9EV50, Q66V81,

saprophyticus, Staphylococcus

Q8NWV5, Q6G9M4,

xylosus, Staphylococcus xylosus,

Q5HG86, Q7A5T2,

Staphylococcus aureus,

Q2FH99, Q99UE2,

Staphylococcus aureus,

Q2YXT2, Q2FYU7,

Staphylococcus aureus,

Q9L451, Q6GH72,

Staphylococcus aureus,

Q9L452

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

694
GPCGPCSEI

Clostridium kluyveri, Streptomyces

A5N7T5, Q827S4
P49588

avermitilis

695
GPCGPCTEIH

Clostridium botulinum, Clostridium

B2THN0, A6LSF6,
Q5JTZ9

beijerinckii, Clostridium botulinum

B2V3W2

696
GPFANIAHG

Bacillus pumilus, Bacillus cereus,

A8FEC9, B7HP29,
P11586

Bacillus cereus, Bacillus cereus,

B9IYP4, B7JLG8,

Bacillus anthracis, Bacillus anthracis,

Q81RE1, C3P858,

Bacillus anthracis, Bacillus

C3LKJ6, Q6HJK9,

thuringiensis, Bacillus cereus, Bacillus

Q63C61, C1ES77,

cereus, Bacillus thuringiensis, Bacillus

A0RD97, Q739F4,

cereus, Bacillus cereus, Bacillus

B7IUA4, Q81E87,

cereus, Lactobacillus casei,

B3WEG3, Q038Y4,

Lactobacillus casei, Lactobacillus

Q5FIU5, Q38X32,

acidophilus, Lactobacillus sakei,

Q1WTW0, A5VHS9,

Lactobacillus salivarius, Lactobacillus

B2G5A9, Q88W76,

reuteri, Lactobacillus reuteri,

B2GF64, Q03S45,

Lactobacillus plantarum, Lactobacillus

Q043I0, Q74JC1,

fermentum, Lactobacillus brevis,

Q5FJY2, B0UQF5,

Lactobacillus gasseri, Lactobacillus

C4ZBG8, Q24ZZ8,

johnsonii, Lactobacillus acidophilus,

Q8RHF4, B1ZJ88,

Methylobacterium sp., Eubacterium
B1M0D1, Q5XZD9,

rectale, Desulfitobacterium hafniense,

B8IBS4, B7L0A5,

Fusobacterium nucleatum,

A9VZT0, Q83WS0,

Methylobacterium populi,

A6LAR6, Q8A9S8,

Methylobacterium radiotolerans,

Q64U80, Q5LD60,

Eubacterium acidaminophilum,

A6L4P0, A7GZZ0,

Methylobacterium nodulans,

A8Z6G1, A3DI22,

Methylobacterium extorquens,

Q07064, Q891R3,

Methylobacterium extorquens,

A5N5B3, B9DYW1,

Methylobacterium extorquens,

P13419, Q97EB3,

Parabacteroides distasonis,

Q189R2, B8I3S9,

Bacteroides thetaiotaomicron,

A9KNJ5, Q4JVW2,

Bacteroides fragilis, Bacteroides

Q6NH87, Q834D6,

fragilis, Bacteroides vulgatus,

B0S0G1, Q7VLW6,

Campylobacter curvus,

B8DDM6, Q71YD9,

Campylobacter concisus, Clostridium

C1KWH6, A0AJY2,

thermocellum, Clostridium

Q92AD2, Q8Y624,

cylindrosporum, Clostridium tetani,

A1KS57, A9M1J1,

Clostridium kluyveri, Clostridium

Q9JXY2, B4RP08,

kluyveri, Clostridium acidurici,

Q5FAG1, Q9JVY8,

Clostridium acetobutylicum,

Q03FM6, Q7MUZ8,

ptoclostridium difficile, Clostridium

Q98HQ4, Q92N42,

cellulolyticum, Clostridium

Q1MDG4, Q2K5P2,

phytofermentans, Corynebacterium

B3PV59, B5ZYA2,

jeikeium, Corynebacterium

C3MFQ8, O66164,

diphtheriae, Enterococcus faecalis,

Q4L776, Q8CNV9,

Finegoldia magna, Haemophilus

Q5HNH4, B9DN77,

ducreyi, Listeria monocytogenes,

Q8NW37, Q6G8J5,

Listeria monocytogenes, Listeria

Q6GFX6, Q5HF42,

monocytogenes, Listeria welshimeri,

Q2G296, A8Z200,

Listeria innocua, Listeria

A6QHR5, Q2FG06,

monocytogenes, Neisseria

Q2YTF6, Q7A535,

meningitidis, Neisseria meningitidis,

A5ITQ4, Q99TD2,

Neisseria meningitidis, Neisseria

A7X3G5, A6U2J8,

gonorrhoeae, Neisseria gonorrhoeae,

Q5X9K7, A2RGS2,

Neisseria meningitidis, Pediococcus

P0DF93, P0DF92,

ntosaceus, Porphyromonas gingivalis,

Q1J9F2, Q1JJK1,

Rhizobium loti, Rhizobium meliloti,

Q1JEK4, Q48QZ2,

Rhizobium leguminosarum,

Q99XR2, Q8NZ49,

Rhizobium etli, Rhizobium etli,

A3CL27, Q1J4C03

Rhizobium leguminosarum,

B9DS83, Q8E5E3,

Rhizobium sp., Sphingomonas
Q3K138, Q8DZP5,

paucimobilis, Staphylococcus

Q59925, C1QEI6,

haemolyticus, Staphylococcus

B1IC26, C1CKW9,

epidermidis, Staphylococcus

B2IP03, C1C7J4,

epidermidis, Staphylococcus

C0MFU5, B4U2T6,

carnosus, Staphylococcus aureus,

C1CR74, Q97QI2,

Staphylococcus aureus,

A3CN49, Q8DPL5,

Staphylococcus aureus,

B8ZJQ0, Q04K90,

Staphylococcus aureus,

B5E4W4, C0M9N3,

Staphylococcus aureus,

A4W0G0, A4VU67,

Staphylococcus aureus,

Q48TE8, P0DF91,

Staphylococcus aureus,

Q1JLK2, Q99ZI9,

Staphylococcus aureus,

A2REC4, Q1JBM0,

Staphylococcus aureus,

P0DF90, Q5XC12,

Staphylococcus aureus,

Q8P0X5, Q1JGN8,

Staphylococcus aureus,

Q1J6F7, Q5M083,

Staphylococcus aureus,

Q5M4U2, Q03L41

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus sanguinis,

Streptococcus pyogenes,

Streptococcus uberis, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus mutans, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus equi,

Streptococcus equi, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

sanguinis, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus equi,

Streptococcus suis, Streptococcus

suis, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus thermophilus

697
GPFANIAHGN

Lactobacillus delbrueckii,

Q1GA94, Q04AM0
P11586

Lactobacillus delbrueckii

698
GPGGYVAAI

Bacillus subtilis, Pseudomonas

P21880, P14218,
P09622

fluorescens, Pseudomonas

Q9I3D1, Q9I1L9,

aeruginosa, Pseudomonas

P09063, Q6GAB8,

aeruginosa, Pseudomonas putida,

P0A0E7, P0A0E8,

Staphylococcus aureus,

Q6GHY9, P99084,

Staphylococcus aureus,

Q5HGY8, P0A0E6

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

699
GPGGYVAAIKAAQ

Pseudomonas putida

P31052
P09622

LG

700
GPGTGIAPF

Citrobacter koseri, Enterobacter sp.,
A8ANX1, A4WDW1,
Q9UBK8

Escherichia coli, Escherichia coli,

Q8FEI7, Q1R7T4,

Escherichia coli, Escherichia coli,

Q0TEA2, A1AEV0,

Escherichia coli, Escherichia coli,

A8A3P5, Q8X7U1,

Escherichia coli, Escherichia coli,

A7ZQK7, B1IU77,

Escherichia coli, Klebsiella

P38038, A6TD49

pneumoniae

701
GPNGAGKSTI

Streptococcus pyogenes,

P0COE3, P0COE2
Q8WWZ7

Streptococcus pyogenes

702
GPNGAGKTT

Escherichia coli, Escherichia coli,

P0A9S7, P0A9S8,
Q86UK0

Pseudomonas aeruginosa

P21629

703
GPNGSGKSN

Lactobacillus plantarum, Bacillus

Q88WJ9, P51834,
Q8NDV3

subtilis, Fusobacterium nucleatum,

Q8REH4, Q24U48,

Desulfitobacterium hafniense,

B9E1H0

Clostridium kluyveri

704
GPNGSGKST

Bacillus halodurans

Q9Z9J3
Q03519

705
GPNTGGMGA

Clostridium acetobutylicum

Q97J90
P22102

706
GPNTGGMGAY

Lactobacillus plantarum,

Q88U30, Q9RHX4,
P22102

Corynebacterium ammoniagenes,

Q9PN47, Q5HTL1,

Campylobacter jejuni, Campylobacter

Q8NMH3, Q8Y6C6,

jejuni, Corynebacterium glutamicum,

Q92AP4, Q71YQ4,

Listeria monocytogenes, Listeria

Q986A5, Q8DRM0,

innocua, Listeria monocytogenes,

Q97T98, Q8P308,

Rhizobium loti, Streptococcus

Q5XEF0,
Q9A1Y7,

pneumoniae, Streptococcus

P0DD58, P0DD59,

pneumoniae, Streptococcus

Q9F159

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus suis

707
GPNTNGSQFFI

Staphylococcus aureus,

Q6GAX2, Q7A6I1,
A0A0B4J2A2

Staphylococcus aureus,

Q7A1C0, Q6GID4,

Staphylococcus aureus,

Q99VD4, Q2FZU9,

Staphylococcus aureus,

Q2FIC1, Q2YWT2,

Staphylococcus aureus,

Q5HHD1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

708
GPPGAGKGTQA

Desulfitobacterium hafniense,

Q250L1, B8G1Y7,
P54819

Desulfitobacterium hafniense,

B3E851, Q82DM5,

Geobacter lovleyi, Streptomyces

P43414, B1W3Y6,

avermitilis, Streptomyces coelicolor,

P49974

Streptomyces griseus, Streptomyces

livid ans

709
GPPGCGKTL

Rhizobium sp.
P55530
Q8NBU5

710
GPPGLGKTT

Corynebacterium jeikeium,

Q4JVD9, C3PGQ6,
Q8WVB6

Corynebacterium aurimucosum,

Q839T5, A8AUH0,

Enterococcus faecalis, Streptococcus

Q5LXQ9, Q03IE9,

gordonii, Streptococcus thermophilus,

Q5M2B1, Q8DWI4,

Streptococcus thermophilus,

B9DSU1, Q1JP25,

Streptococcus thermophilus,

Q1JE69, B5XJ28,

Streptococcus mutans, Streptococcus

A2RC05, Q1JJ71,

uberis, Streptococcus pyogenes,

Q1J924, Q5XEE4,

Streptococcus pyogenes,

Q9A1Y1, Q8P302,

Streptococcus pyogenes,

P0DF51, Q48VY1,

Streptococcus pyogenes,

P0DF50, Q8E2D9,

Streptococcus pyogenes,

Q8E7U6, Q3K3X8,

Streptococcus pyogenes,

A4VSD3, A4VYM0,

Streptococcus pyogenes,

C1CPD4, C1CIE0,

Streptococcus pyogenes,

Q8CVVU7, B1I8Y6,

Streptococcus pyogenes,

Q04MI9, C1CB34,

Streptococcus pyogenes,

B5E6T3, ClCC50,

Streptococcus pyogenes,

C0MC84, A3CK22,

Streptococcus pyogenes,

B2ISI4, Q97SR6,

Streptococcus agalactiae,

B4U5F8

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus suis, Streptococcus

suis, Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus equi, Streptococcus

sanguinis, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus equi

711
GPPGLGKTTL

Arcobacter butzleri, Bacillus

A8EVP9, Q9KDI8,
Q8WVB6

halodurans, Helicobacter hepaticus,

Q7VIU8, Q49Y79,

Staphylococcus saprophyticus,

B45T32, B2FRN4

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

712
GPPGLGKTTLA

Acinetobacter baumannii,

A3M7W1, B2HWT3,
Q8WVB6

Acinetobacter baumannii,

B0VDI5, B7GYB5,

Acinetobacter baumannii,

B0VT89, B7I5A9,

Acinetobacter baumannii,

Q6F991, A4SJ26,

Acinetobacter baumannii,

A0KPA2, B2UPI9,

Acinetobacter baumannii,

B7IIT2, B7HE54,

Acinetobacter baylyi, Aeromonas

Q817W4, A7GTA2,

salmonicida, Aeromonas hydrophila,

A9VIP6, A7Z768,

Akkermansia muciniphila, Bacillus

P61533, B7HQH9,

cereus, Bacillus cereus, Bacillus

P61528, Q045Q2,

cereus, Bacillus cytotoxicus, Bacillus

B9IYZ4, Q634C4,

weihenstephanensis, Bacillus

Q6HDA6, C1ESW4,

methylotrophicus, Lactobacillus

Q81LG9, C3L6U9,

johnsonii, Bacillus cereus, Bacillus

C3P9A7, A0RJ26,

cereus, Lactobacillus gasseri, Bacillus

Q048Y7, Q1G941,

cereus, Bacillus cereus, Bacillus

O32055, Q5FLX2,

thuringiensis, Bacillus cereus, Bacillus

Q1WT18, B2G6E8,

anthracis, Bacillus anthracis, Bacillus

A5VIX2, Q65GP6,

anthracis, Bacillus thuringiensis,

B3WC56, Q03B17,

Lactobacillus delbrueckii,

A8YTI2, Q88V03,

Lactobacillus delbrueckii, Bacillus

Q03R36, Q8RE97,

subtilis, Lactobacillus acidophilus,

A1A1K3, B7GR18,

Lactobacillus salivarius, Lactobacillus

Q24UN7, B8FQV5,

reuteri, Lactobacillus reuteri, Bacillus

Q8G6B7, Q183N8,

licheniformis, Lactobacillus casei,

A0PZV4, Q0TP13,

Lactobacillus casei, Lactobacillus

Q8XJ14, Q891Z8,

helveticus, Lactobacillus plantarum,

Q97GT1, A6LTM7,

Lactobacillus brevis, Fusobacterium

Q0SRN3, A9KP49,

nucleatum, Bifidobacterium

A3DBU4, A5N206,

adolescentis, Bifidobacterium longum,

B9E5Q8, B1IMF3,

Desulfitobacterium hafniense,

A7GHT8, C1FKG1,

Desulfitobacterium hafniense,

C3KTD2, A5I6F1,

Bifidobacterium longum,

A7FY19, B1L0B2,

ptoclostridium difficile, Clostridium

B2TMZ2, B2V338,

novyi, Clostridium perfringens,

A5G9Y2, B3E468,

Clostridium perfringens, Clostridium

B9LZC4, P61532,

tetani, Clostridium acetobutylicum,

B5EAH3, Q39XN6,

Clostridium beijerinckii, Clostridium

C6E1S8, Q4QNM6,

perfringens, Clostridium

P44631, A5UAH8,

phytofermentans, Clostridium

Q7VKV5, Q011M3,

thermocellum, Clostridium kluyveri,

Q03YJ6, Q92B12,

Clostridium kluyveri, Clostridium

Q8Y6Z8, B8DHL6,

botulinum, Clostridium botulinum,

A0AIY1, Q71ZD8,

Clostridium botulinum, Clostridium

C1KVH9, Q03ER0,

botulinum, Clostridium botulinum,

B4ETP8, B1JD70,

Clostridium botulinum, Clostridium

Q1I6E9, Q4ZWL1,

botulinum, Clostridium botulinum,

A4XRS1, Q48FC5,

Clostridium botulinum, Geobacter

Q3K7W0, A6VA05,

uraniireducens, Geobacter lovleyi,

B0KTJ2, Q02IC9,

Geobacter daltonii, Geobacter

B7UXW5, Q51426,

sulfurreducens, Geobacter

Q87Y35, Q88NJ0,

bemidjiensis, Geobacter

C3JYS7, A5VZU7,

metallireducens, Geobacter sp.,
A4VNA3, Q4K7D9,

Haemophilus influenzae,

Q98F76

Haemophilus influenzae,

Haemophilus influenzae,

Haemophilus ducreyi, Haemophilus

somnus, Leuconostoc mesenteroides,

Listeria innocua, Listeria

monocytogenes, Listeria

monocytogenes, Listeria welshimeri,

Listeria monocytogenes, Listeria

monocytogenes, Pediococcus

ntosaceus, Proteus mirabilis,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas syringae,

Pseudomonas mendocina,

Pseudomonas savastanoi,

Pseudomonas fluorescens,

Pseudomonas aeruginosa,

Pseudomonas putida, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas putida,

Pseudomonas stutzeri, Pseudomonas

fluorescens, Rhizobium loti

713
GPPGLGKTTLAH

Campylobacter concisus,

A7ZEM1, A7I1C5,
Q8WVB6

Campylobacter hominis,

A0RN84, A7GZP9,

Campylobacter fetus, Campylobacter

B4RLV8, Q5F8L2,

curvus, Neisseria gonorrhoeae,

A1KU52, Q9JZ86,

Neisseria gonorrhoeae, Neisseria

A9LZC3, Q9JUB0,

meningitidis, Neisseria meningitidis,

B2UFL1, Q8Y236

Neisseria meningitidis, Neisseria

meningitidis, Ralstonia pickettii,

Ralstonia solanacearum

714
GPPGSGKGT

Micrococcus luteus, Micrococcus

P33107, C5CC42
P27144

luteus

715
GPPGTGKTL

Clostridium phytofermentans,

A9KIG5, A5W382
Q9Y4W6

Pseudomonas putida

716
GPPGTGKTLLA

Bacillus pseudofirmus,

P94304, Q6M2F0,
Q9Y4W6

Corynebacterium glutamicum,

P71377, D4HA34,

Haemophilus influenzae,

C7N1I1, Q4L3G8

Propionibacterium acnes, Slackia

heliotrinireducens, Staphylococcus

haemolyticus

717
GPPGTGKTLLAKA

Bacillus subtilis, Lactobacillus

P37476, Q88Z31,
Q9Y4W6

plantarum, Lactobacillus plantarum,

C6VKW6, A6LD25,

Parabacteroides distasonis,

A0PXM8, B8I4B9,

Clostridium novyi, Clostridium

Q0TTK8, P0AAI3,

cellulolyticum, Clostridium

Q8X9L0, O32617,

perfringens, Escherichia coli,

Q9ZM66, P71408,

Escherichia coli, Helicobacter felis,

Q03Z46, O69076,

Helicobacter pylori, Helicobacter

P59652, D1BLD0

pylori, Leuconostoc mesenteroides,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Veillonella parvula

718
GPPGTGKTT

Escherichia coli, Escherichia coli,

P0AAZ5, P0AAZ4,
P35250

Escherichia coli, Haemophilus

P0AAZ6, P45262

influenzae

719
GPPGVGKTS

Acinetobacter baumannii, Bacillus

B7GXS7, A0RJ87,
P36776

thuringiensis, Bacillus subtilis,

P37945, A7ZEJ3,

Campylobacter concisus, Clostridium

A6LSV5, B8J198,

beijerinckii, Desulfovibrio

Q72CE6, P0A9M0,

desulfuricans, Desulfovibrio vulgaris,

P0A9M1, B5EDX8,

Escherichia coli, Escherichia coli,

Q39OP7, B3E7K2,

Geobacter bemidjiensis, Geobacter

P43864, O69177

metallireducens, Geobacter lovleyi,

Haemophilus influenzae, Rhizobium

meliloti

720
GPPGVGKTSIA

Clostridium acetobutylicum,

Q97FT9, B1GZQ6
P36776

Uncultured termite

721
GPPHDRRFT

Geobacter metallireducens

Q39T82
P19525

722
GPQHPAAHGVLR

Stenotrophomonas maltophilia

B4SJH6
O75306

LV

723
GPRYCPSIE

Bacillus halodurans, Bacillus

Q9RCA8, A7ZAW0,
Q9Y2Z2

methylotrophicus, Bacillus clausii,

Q5WAG4, P25812,

Bacillus subtilis, Bacillus pumilus,

A8FJF9, Q1G7Z5,

Lactobacillus delbrueckii,

Q047G0, Q38UF0,

Lactobacillus delbrueckii,

Q88RX6, Q1WVH6,

Lactobacillus sakei, Lactobacillus

Q03N65, Q24M99,

plantarum, Lactobacillus salivarius,

B8GOL2, A7GWM5,

Lactobacillus brevis,

A7ZBK0, Q97CVV3,

Desulfitobacterium hafniense,

A5N450, A6M3M4,

Desulfitobacterium hafniense,

Q181S8, Q0TLZ5,

Campylobacter curvus,

Q8XH31, Q0SPQ4,

Campylobacter concisus, Clostridium

Q17VU9, Q03D60

acetobutylicum, Clostridium kluyveri,

Clostridium beijerinckii, ptoclostridium

difficile, Clostridium perfringens,

Clostridium perfringens, Clostridium

perfringens, Helicobacter acinonychis,

Pediococcus ntosaceus

724
GPSGAGKST

Clostridium tetani, Haemophilus

Q895P5, P45092
Q16774

influenzae

725
GPSGAGKSTF

Bacillus subtilis, Bacillus halodurans

O34814, Q9KFL0
Q9H172

726
GPSGAGKSTL

Clostridium botulinum, Clostridium

B2V4B8, B2THS4,
Q16774

botulinum, Clostridium beijerinckii,

A6LSK4, P31548,

Escherichia coli, Escherichia coli,

Q8XA06, Q1RGD0

Escherichia coli

727
GPSGAGKSTLL

Clostridium perfringens, Clostridium

Q0TPL7, Q8XJL9,
Q16774

perfringens, Clostridium perfringens,

Q0SS84, Q8FL82,

Escherichia coli, Escherichia coli

Q0TLS2

728
GPSGSGKSS

Rhizobium sp.
P55453
Q9NP78

729
GPSGSGKST

Bacillus subtilis, Rhizobium

P54537, Q52815
Q9NRK6

leguminosarum

730
GPTGSGKTLLA

Aeromonas hydrophila, Aeromonas

A0KJU2, A4SM43,
O76031

salmonicida, Citrobacter koseri,

A8AK15, A4W7A9,

Enterobacter sp., Escherichia
B7LME1, Q1RF97,

fergusonii, Escherichia coli,

B1LJJ5, B6HZP5,

Escherichia coli, Escherichia coli,

B7N8Z2, B1J010,

Escherichia coli, Escherichia coli,

P0A6H1, P0A6H2,

Escherichia coli, Escherichia coli,

Q0TKK3, A1A8A7,

Escherichia coli, Escherichia coli,

A7ZX96, B1XFM6,

Escherichia coli, Escherichia coli,

C4ZTJ5, B7M3T1,

Escherichia coli, Escherichia coli,

B7MQF4, B7NJ56,

Escherichia coli, Escherichia coli,

B5Z3U5, P0A6H3,

Escherichia coli, Escherichia coli,

B7L675, B7MD97,

Escherichia coli, Escherichia coli,

B7UJR1, A7ZIJ6,

Escherichia coli, Escherichia coli,

Q7VP79, B5YOU1,

Haemophilus ducreyi, Klebsiella

A6T5I1, B4EU54,

pneumoniae, Klebsiella pneumoniae,

A5W634, B0KJG7,

Proteus mirabilis, Pseudomonas

Q88KI9, B1J693,

putida, Pseudomonas putida,

A4XTZ6, Q87YR7,

Pseudomonas putida, Pseudomonas

Q4ZVM6, Q9I2U0,

putida, Pseudomonas mendocina,

A6V718, Q02KU5,

Pseudomonas syringae,

B7VB75, Q48KY9,

Pseudomonas syringae,

Q3K9X0, C3JYJ9,

Pseudomonas aeruginosa,

B2FQR3, B4SLN2

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas savastanoi,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

731
GPTGSGKTLLAQ

Neisseria meningitidis, Neisseria

A9M020, A1KUJ4,
O76031

meningitidis, Neisseria meningitidis,

Q9JTX8, Q9JYY3

Neisseria meningitidis

732
GPTGSGKTLLAQT

Sphingomonas wittichii

A5V3U4
O76031

733
GPTGSGKTLLAQT

Acinetobacter baylyi, Acinetobacter

Q6FEP7, B0V4T7,
O76031

LA

baumannii, Acinetobacter baumannii,

A3M1Y8, B0VKU4,

Acinetobacter baumannii,

B2I3C2, B7I5E4,

Acinetobacter baumannii,

B7H092, A8FFV9,

Acinetobacter baumannii,

Q65GJ4, P50866,

Acinetobacter baumannii, Bacillus

Q6HD54, Q633X2,

pumilus, Bacillus licheniformis,

B7HQN2, B9IZ47,

Bacillus subtilis, Bacillus thuringiensis,

C1ETR8, Q72ZV4,

Bacillus cereus, Bacillus cereus,

B7JQ65, Q81LB9,

Bacillus cereus, Bacillus cereus,

C3L704, C3P9F7,

Bacillus cereus, Bacillus cereus,

A7Z7B2, Q817Q2,

Bacillus anthracis, Bacillus anthracis,

B7HEA4, B7IIY3,

Bacillus anthracis, Bacillus

A7GTF1, Q5WEN9,

methylotrophicus, Bacillus cereus,

Q9K8F4, B0UD19,

Bacillus cereus, Bacillus cereus,

B7KNT1, A9W5F6,

Bacillus cytotoxicus, Bacillus clausii,

B1LW29, B8IN27,

Bacillus halodurans,

B1Z9C8, P44838,

Methylobacterium sp.,
Q0I4F0, Q92C84,

Methylobacterium extorquens,

Q8Y7K9, C1L2H6,

Methylobacterium extorquens,

B8DHN7, Q720F3,

Methylobacterium radiotolerans,

A0AI71, Q8XYP6,

Methylobacterium nodulans,

B2UFQ3

Methylobacterium populi,

Haemophilus influenzae,

Haemophilus somnus, Listeria

innocua, Listeria monocytogenes,

Listeria monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Listeria welshimeri,

Ralstonia solanacearum, Ralstonia

pickettii

734
GPTGSGKTLLAQT

Campylobacter jejuni, Staphylococcus

Q9PIM0, B9DNC0,
O76031

LAK

carnosus, Staphylococcus

Q8CNY5, Q5HNM9

epidermidis, Staphylococcus

epidermidis

735
GQDPYHGPNQA

Streptococcus mutans

Q8DTV8
P13051

736
GQDVLLFIDNIFRF

Clostridium thermocellum

A3DIM9
P06576

737
GQEVTLCGW

Edwardsiella ictaluri, Pseudomonas

C5B957, Q51422,
Q6PI48

aeruginosa, Pseudomonas

B7UXW9, Q02IC5,

aeruginosa, Pseudomonas

Q4K7D5, Q88NJ4,

aeruginosa, Pseudomonas

A5VZU3, B0KTJ6,

fluorescens, Pseudomonas putida,

Q1I6E5, B1JD74

Pseudomonas putida, Pseudomonas

putida, Pseudomonas entomophila,

Pseudomonas putida

738
GQKCSACSR

Bacillus thuringiensis, Bacillus cereus,

Q6HP91, B9J1L9,
P30038

Bacillus cereus, Bacillus anthracis,

Q63GS0, C3PBP4,

Bacillus cereus, Bacillus cereus,

B7HSW8, C1EV77,

Bacillus cereus, Bacillus anthracis,

B7JM99, C3L546,

Bacillus thuringiensis, Bacillus

A0R909, Q81ZF8,

anthracis, Bacillus

A9VRG6, P62028,

weihenstephanensis, Bacillus cereus,

A7GKJ4, Q81IP0,

Bacillus cytotoxicus, Bacillus cereus,

B7H4V1, B7IUW8

Bacillus cereus, Bacillus cereus

739
GQMNEPPGAR

Clostridium perfringens, Clostridium

Q0SQZ5, Q0TNC4,
P06576

perfringens, Clostridium perfringens

Q8XID4

740
GQRELIIGDRQ

Clostridium novyi

A0Q2Z6
P25705

741
GQRELIIGDRQTG

Clostridium botulinum, Clostridium

C3KYJ1, A5HY50,
P25705

KT

botulinum, Clostridium botulinum,

C1FQP3, A7FQH7,

Clostridium botulinum, Clostridium

B1KSS6, B1IE32,

botulinum, Clostridium botulinum,

A7G9Q7, B2UZJ8,

Clostridium botulinum, Clostridium

Q9Z689, B2TJZ8

botulinum, Clostridium

acetobutylicum, Clostridium botulinum

742
GRELGLPEE

Corynebacterium glutamicum,

Q8NSR1, A4QBV0,
P49915

Corynebacterium glutamicum,

Q4JTG0

Corynebacterium jeikeium

743
GRFVIGGPQGDA

Lactobacillus plantarum, Lactobacillus

Q88XB8, Q1UVUT4
Q00266

G

salivarius

744
GRGERAYDIYSRL

Geobacter lovleyi, Ralstonia

B3E1Z4, Q8XYP7
Q16740

L

solanacearum

745
GRGGAGFPTG

Pseudomonas aeruginosa

Q9I0J7
P49821

746
GRGQRELIIGDRQ

Sphingomonas wittichii

A5V3X3
P25705

TGK

P25705

747
GRGQRELIIGDRQ

Methylobacterium extorquens,

A9W2R3, B7KUA4,

TGKT

Methylobacterium extorquens,

Q39Q54

Geobacter metallireducens

748
GRGTSTYDG

Bacillus cereus, Bacillus anthracis,

B7HDP4, C3L822,
P43246

Bacillus anthracis, Bacillus anthracis,

Q81WR3, C3P5H5,

Bacillus thuringiensis, Bacillus cereus,

A0RHE1, B7JJ47,

Bacillus cereus, Bacillus thuringiensis,

C1ENZ3, Q6HF46,

Bacillus cereus, Bacillus cereus,

B7HLA3, B9IV59,

Bacillus cereus, Bacillus cereus,

P61665, Q636Q7,

Bacillus licheniformis, Bacillus

Q65JE2, A9VS13,

weihenstephanensis, Bacillus cereus,

B7ITM1, Q81A25,

Bacillus cereus, Bacillus pumilus,

A8FDH3, Q9KAC0,

Bacillus halodurans, Fusobacterium

Q8RFK2, Q0TRD6,

nucleatum, Clostridium perfringens,

Q8XL87, Q0STR4,

Clostridium perfringens, Clostridium

Q187T6, A3DDI3,

perfringens, ptoclostridium difficile,

A5I2S2, A7FUL0,

Clostridium thermocellum, Clostridium

C1FNT9, A7GE45,

botulinum, Clostridium botulinum,

B1IM68, C3KX35,

Clostridium botulinum, Clostridium

B1KSA3, A5N8I5,

botulinum, Clostridium botulinum,

B9E1Z0, A0Q0M6,

Clostridium botulinum, Clostridium

A6LWJ5, B2TIC3,

botulinum, Clostridium kluyveri,

B2V1M2, B8J008,

Clostridium kluyveri, Clostridium

B0S1C1, Q4L5Z9,

novyi, Clostridium beijerinckii,

Q8CPF0, Q5HPP5,

Clostridium botulinum, Clostridium

P65494, P0C1S1,

botulinum, Desulfovibrio

A8Z1W6, Q6G9R8,

desulfuricans, Finegoldia magna,

P65493, A6QGJ4,

Staphylococcus haemolyticus,

Q931S8, A5ISH9,

Staphylococcus epidermidis,

Q5HGD6, A7X1T6,

Staphylococcus epidermidis,

Q2FYZ9, A6U1B4,

Staphylococcus aureus,

Q2YXR9, Q6GHE0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

749
GRIDILVNN

Escherichia coli, Escherichia coli

P37440, Q8XBJ4
Q9Y394

750
GRIVETEAY

Rhizobium loti

Q98DR6
P29372

751
GRKMSKSLGN

Lactobacillus plantarum, Lactobacillus

Q88V89, Q039Q9,
P26640

casei, Lactobacillus casei,

B3WDZ1, Q38XM0

Lactobacillus sakei

752
GRKMSKSLGNV

Bacillus licheniformis

Q65JV7
P26640

753
GRLDVLVNN

Methylobacterium extorquens

Q49117
Q96LJ7

754
GRLKTGTPPRI

Neisseria meningitidis, Neisseria

A9M3R4, A1KRM5,
Q9Y2Z2

meningitidis, Neisseria gonorrhoeae,

Q5F5Y0, Q9JX41,

Neisseria meningitidis, Neisseria

Q9K1G0, Q8XU65,

meningitidis, Ralstonia solanacearum,

B2UGW0

Ralstonia pickettii

755
GRNIIHGSDS

Staphylococcus epidermidis,

Q5HP76, Q8CSI0
O60361

Staphylococcus epidermidis

756
GRPGWHIECS

Lactobacillus plantarum, Lactobacillus

Q88YX9, Q03SU6,
P49589

brevis, Lactobacillus fermentum,

B2GAB5, Q1WSS5,

Lactobacillus salivarius, Eubacterium

C4Z3N5, Q0TMM4,

eligens, Clostridium perfringens,

Q0SQC1, Q8XHQ5,

Clostridium perfringens, Clostridium

B2TIF6, B2UY90,

perfringens, Clostridium botulinum,

Q890M4, A6LPP1,

Clostridium botulinum, Clostridium

A5N4M6, B9DY88,

tetani, Clostridium beijerinckii,

B1IGH6, C1FMX3,

Clostridium kluyveri, Clostridium

A5I7M8, A7FZ91,

kluyveri, Clostridium botulinum,

A7GJ96, B1KTA5,

Clostridium botulinum, Clostridium

C3KVS3, Q18CD5,

botulinum, Clostridium botulinum,

A9KSM5, Q03ZR0,

Clostridium botulinum, Clostridium

Q03E41, Q4K9S1,

botulinum, Clostridium botulinum,

Q4ZVN9, C3JYD3,

ptoclostridium difficile, Clostridium

Q87YQ2, B0KUU0,

phytofermentans, Leuconostoc

A5W458, Q48L06,

mesenteroides, Pediococcus

Q88IU4, Q02KT6,

ntosaceus, Pseudomonas

Q9I2U7, B7VB84,

fluorescens, Pseudomonas syringae,

A6V727, Q3KA28,

Pseudomonas fluorescens,

Q1IBP9, A4VL73,

Pseudomonas syringae,

B1J805, Q6GJD9,

Pseudomonas putida, Pseudomonas

A8YZM7, Q5HIE5,

putida, Pseudomonas savastanoi,

Q2G2M6, A6QEI2,

Pseudomonas putida, Pseudomonas

Q2FJB0, Q99W73,

aeruginosa, Pseudomonas

Q932G0, A5IQ83,

aeruginosa, Pseudomonas

A7WYU7, A6TZ06,

aeruginosa, Pseudomonas

Q8NXY7, Q6GBV8,

aeruginosa, Pseudomonas

Q2YSD1, Q49V39,

fluorescens, Pseudomonas

Q4L3I9, Q8D058,

entomophila, Pseudomonas stutzeri,

Q97S25, Q8DWA9,

Pseudomonas putida, Staphylococcus

B4U570, Q5M6F6,

aureus, Staphylococcus aureus,

Q5M1W6, Q99XZ9,

Staphylococcus aureus,

Q5X9W5, P0DG33,

Staphylococcus aureus,

P0DG32, Q48RA7,

Staphylococcus aureus,

Q8NZD1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Staphylococcus haemolyticus,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus mutans, Streptococcus

equi, Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

757
GRPGWHIECSA

Listeria innocua, Listeria

Q92F36, Q8YAB1,
P49589

monocytogenes, Listeria

C1KYH2, B8DF15,

monocytogenes, Listeria

Q724H3, A0AF38

monocytogenes, Listeria

monocytogenes, Listeria welshimeri

758
GRPGWHIECSAM

Acinetobacter baumannii,

B0V571, B0VAU1,
P49589

Acinetobacter baumannii,

B7GWA1, B7IBU3,

Acinetobacter baumannii,

B2HX34, A3M419,

Acinetobacter baumannii,

Q6FC71, A8F962,

Acinetobacter baumannii,

Q5WLT3, Q72BNQ5,

Acinetobacter baumannii,

A1VDQ5, B8DKL0,

Acinetobacter baylyi, Bacillus pumilus,

Q30ZH8, B8J052,

Bacillus clausii, Desulfovibrio vulgaris,

A4W7I4, P21888,

Desulfovibrio vulgaris, Desulfovibrio

C4ZUX4, B1XGC4,

vulgaris, Desulfovibrio alaskensis,

Q0TKB5, B1LKE5,

Desulfovibrio desulfuricans,

B7LJI4, B6I0H1,

Enterobacter sp., Escherichia coli,
Q1RF08, Q8FK44,

Escherichia coli, Escherichia coli,

B1IZ75, A1A8J2,

Escherichia coli, Escherichia coli,

B7M4M9, A7ZXI1,

Escherichia fergusonii, Escherichia

B7MRI9, B5YPP1,

coli, Escherichia coli, Escherichia coli,

B7NL20, B7L7F3,

Escherichia coli, Escherichia coli,

B7ME49, Q8XCT9,

Escherichia coli, Escherichia coli,

A7ZIT5, B7N980,

Escherichia coli, Escherichia coli,

B7UKK3, Q747A2,

Escherichia coli, Escherichia coli,

C6E7P0, B5EEK6,

Escherichia coli, Escherichia coli,

Q39ZL8, Q7VMA0,

Escherichia coli, Escherichia coli,

Q4QPG7, A5UFP3,

Escherichia coli, Geobacter

P43816, Q0I1Q1,

sulfurreducens, Geobacter sp.,
A6T5R2, B5Y0K6,

Geobacter bemidjiensis, Geobacter

Q5F5D6, Q9JXE6,

metallireducens, Haemophilus

Q9JWJ3, B4F1M6,

ducreyi, Haemophilus influenzae,

B2U9P8, Q8Y077,

Haemophilus influenzae,

Q2KAA8, Q1MJ22,

Haemophilus influenzae,

B5ZWB3, Q984X8,

Haemophilus somnus, Klebsiella

B3PUS4, Q92R20

pneumoniae, Klebsiella pneumoniae,

Neisseria gonorrhoeae, Neisseria

meningitidis, Neisseria meningitidis,

Proteus mirabilis, Ralstonia pickettii,

Ralstonia solanacearum, Rhizobium

etli, Rhizobium leguminosarum,

Rhizobium leguminosarum,

Rhizobium loti, Rhizobium etli,

Rhizobium meliloti

759
GRPGWHIECSAM

Bacillus cereus, Bacillus cereus,

Q81J59, B7HJ28,
P49589

A

Bacillus cereus, Bacillus cereus,

C1ET19, Q73FB7,

Bacillus thuringiensis, Bacillus cereus,

Q6HPS8, Q63HB0,

Bacillus anthracis, Bacillus anthracis,

Q8VV1, C3P9N5,

Bacillus cereus, Bacillus anthracis,

B7JK97, C3LJ62,

Bacillus cereus, Bacillus cereus,

B7ISZ9, B9IZH4,

Bacillus cereus, Bacillus thuringiensis,

B7HQS4, A0R8G1,

Corynebacterium jeikeium

Q4JXJ2

760
GRSNVGKSS

Bacillus halodurans, Bacillus clausii,

Q9K8F7, Q5WEP2,
Q8N3Z3

Bacillus cytotoxicus, Bacillus

A7GTE8, A9VIU3,

weihenstephanensis, Bacillus cereus,

B7IIY0, Q817Q5,

Bacillus cereus, Bacillus cereus,

B7HEA1, Q6HD57,

Bacillus thuringiensis, Bacillus

Q81LC2, Q633X5,

anthracis, Bacillus cereus, Bacillus

C1ETR5, B9IZ44,

cereus, Bacillus cereus, Bacillus

B7HQM9, B7JQ62,

cereus, Bacillus cereus, Bacillus

C3P9F4, Q72ZV7,

anthracis, Bacillus cereus, Bacillus

A0RJ86, C3L700,

thuringiensis, Bacillus anthracis,

A7Z7A9, Q65GJ7,

Bacillus methylotrophicus, Bacillus

Q04B34, Q1GAP7,

licheniformis, Lactobacillus

P38424, A8FFV6,

delbrueckii, Lactobacillus delbrueckii,

Q180E5, Q833M8,

Bacillus subtilis, Bacillus pumilus,

B0S273, A0AJ07,

ptoclostridium difficile, Enterococcus

Q92BF6, B8DHJ0,

faecalis, Finegoldia magna, Listeria

Q71ZB0, C1KVK5,

welshimeri, Listeria innocua, Listeria

Q8Y6X3, Q4L712,

monocytogenes, Listeria

Q8DUH9, C0MA50,

monocytogenes, Listeria

C0MEW6, B2IR86,

monocytogenes, Listeria

C1CSI8, B8ZLT0,

monocytogenes, Staphylococcus

B1ICY8, B9DU74,

haemolyticus, Streptococcus mutans,

C1CFF1, A3CMV2,

Streptococcus equi, Streptococcus

Q8P1C8, P64073,

equi, Streptococcus pneumoniae,

P64072, C1C8F9,

Streptococcus pneumoniae,

B5E6L1, Q04JI0,

Streptococcus pneumoniae,

C1CLR7, Q48U21,

Streptococcus pneumoniae,

A2RF16, Q1J740,

Streptococcus uberis, Streptococcus

Q5XCL9, Q9A088,

pneumoniae, Streptococcus

B5XL04, Q1JHC1,

sanguinis, Streptococcus pyogenes,

Q1JM76, Q1JC92,

Streptococcus pneumoniae,

Q03LM9, Q8DZ11,

Streptococcus pneumoniae,

Q3K0K1, Q8E4L9,

Streptococcus pneumoniae,

P0DA93, P0DA92,

Streptococcus pneumoniae,

A8AX68, Q5M053,

Streptococcus pneumoniae,

Q5M5A9

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus thermophilus,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus gordonii,

Streptococcus thermophilus,

Streptococcus thermophilus

761
GRSNVGKSSL

Lactobacillus brevis, Lactobacillus

Q03QN8, B2G6R5,
Q8N3Z3

reuteri, Lactobacillus reuteri,

A5VJ95, B2GBC5,

Lactobacillus fermentum,

B8J030, Q30ZZ9,

Desulfovibrio desulfuricans,

A1VDC5, Q72BH2,

Desulfovibrio alaskensis,

C6E8C5, B5EEM1,

Desulfovibrio vulgaris, Desulfovibrio

B1MXT9, Q03W10,

vulgaris, Geobacter sp., Geobacter
Q03F28

bemidjiensis, Leuconostoc citreum,

Leuconostoc mesenteroides,

Pediococcus ntosaceus

762
GRSNVGKSSLI

Lactobacillus plantarum, Lactobacillus

Q88VE3, Q1WUI3,
Q8N3Z3

salivarius, Desulfitobacterium

Q245K9, B8FVH0,

hafniense, Desulfitobacterium

C6BUE5, B3Q039,

hafniense, Desulfovibrio salexigens,

C3MF47, Q2KD28,

Rhizobium etli, Rhizobium sp.,
Q98D85, Q1MM59,

Rhizobium etli, Rhizobium loti,

B5ZN41

Rhizobium leguminosarum,

Rhizobium leguminosarum

763
GRVKTLHPA

Clostridium novyi, Listeria

A0Q1J0, Q71YQ3,
P31939

monocytogenes, Listeria

Q8Y6C5, C1KW64,

monocytogenes, Listeria

Q92AP3, A0AJL9,

monocytogenes, Listeria innocua,

B8DDZ2, Q03E83

Listeria welshimeri, Listeria

monocytogenes, Pediococcus

ntosaceus

764
GRVKTLHPAVH

Clostridium tetani, Staphylococcus

Q892X3, Q6GI11,
P31939

aureus, Staphylococcus aureus,

Q2YX50, P67544,

Staphylococcus aureus,

A5IRW0, P67543,

Staphylococcus aureus,

A6U0P1, Q8CT27,

Staphylococcus aureus,

Q5HQ97, Q2FI05,

Staphylococcus aureus,

Q5HH11, Q8NX88,

Staphylococcus epidermidis,

Q6GAE0, Q2FZI6,

Staphylococcus epidermidis,

A6QFT1, Q4L582,

Staphylococcus aureus,

B9DQ42

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus carnosus

765
GRVQGVCFR

Rhizobium meliloti

Q92TK9
P14621

766
GRYREFYQCD

Clostridium acetobutylicum

Q97FJ7
P12081

767
GSDFIKTSTG

ptoclostridium difficile

Q18C22
Q9Y315

768
GSIRSPLWRGG

Desulfovibrio vulgaris, Desulfovibrio

A1VEB5, Q72CH9
Q9BYD3

vulgaris

769
GSLTTPPCSE

Klebsiella pneumoniae

O52535
P23470

770
GSLTTPPCTE

Neisseria gonorrhoeae

Q50940
P23280

771
GSPAEKAGL

Bacillus subtilis, Neisseria

Q34358, Q9K1G9,
O14745

meningitidis, Neisseria meningitidis

Q9JX32

772
GSSQRFGVP

Propionibacterium acnes,

Q6A9R8, Q3K4Z1,
P23378

Pseudomonas fluorescens,

Q1MG62

Rhizobium leguminosarum

773
GSVPHGGFG

Streptococcus thermophilus,

Q5M067, Q5M458,
Q96159

Streptococcus thermophilus,

Q03L20, A2RFM5,

Streptococcus thermophilus,

P0DG29, Q48UH6,

Streptococcus pyogenes,

Q1JHS6, P67577,

Streptococcus pyogenes,

P0DG28, P67575,

Streptococcus pyogenes,

Q1JMN3, Q1JCQ7,

Streptococcus pyogenes,

Q5XD20, P67574,

Streptococcus pyogenes,

P67573, Q3K2E5,

Streptococcus pyogenes,

Q1J7K5, A4W083,

Streptococcus pyogenes,

A4VTZ1

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus suis, Streptococcus

suis

774
GTDVAKEAS

Bacillus subtilis

O34431
Q01814

775
GTGKTLLAR

Bacteroides thetaiotaomicron,

Q8A128, Q64NW3,
P62195

Bacteroides fragilis, Bacteroides

Q5L8L7, Q7MX10,

fragilis, Porphyromonas gingivalis,

B2RL24

Porphyromonas gingivalis

776
GTIGHVDHG

Arcobacter butzleri, Lactobacillus

A8EW02, A8YUS2,
P49411

helveticus, Lactobacillus johnsonii,

Q74JU6, Q042T5,

Lactobacillus gasseri, Lactobacillus

Q5FKR8, B3WE38,

acidophilus, Lactobacillus casei,

Q039K9, Q04B37,

Lactobacillus casei, Lactobacillus

Q1GAQ0, Q88VE0,

delbrueckii, Lactobacillus delbrueckii,

A7GK18, Q38WR7,

Lactobacillus plantarum, Bacillus

A9VP75, Q6HPR0,

cytotoxicus, Lactobacillus sakei,

Q814C4, Q63H92,

Bacillus weihenstephanensis, Bacillus

B7HJ46, C1ET37,

thuringiensis, Bacillus cereus, Bacillus

A0R8H8, B7JKB7,

cereus, Bacillus cereus, Bacillus

C3LJ80, Q81VT2,

cereus, Bacillus thuringiensis, Bacillus

C3P9Q3, B9IZJ2,

cereus, Bacillus anthracis, Bacillus

B7HQU2, Q73F98,

anthracis, Bacillus anthracis, Bacillus

B7IT17, Q1WU83,

cereus, Bacillus cereus, Bacillus

P33166, B2GBC2,

cereus, Bacillus cereus, Lactobacillus

A8F982, P33165,

salivarius, Bacillus subtilis,

Q5L890, Q8A463,

Lactobacillus fermentum, Bacillus

A6KYK9, A0RQJ3,

pumilus, Bacteroides fragilis,

A7GZK6, A7ZCN0,

Bacteroides fragilis, Bacteroides

A7I3U7, B9KFF9,

thetaiotaomicron, Bacteroides

Q5HVZ7, O69303,

vulgatus, Campylobacter fetus,

A1VYI6, A7H4R3,

Campylobacter curvus,

A8FKQ5, B1KSM7,

Campylobacter concisus,

A5I7K8, A7GJ76,

Campylobacter hominis,

B1IGF6, A7FZ71,

Campylobacter lari, Campylobacter

A5N4N1, A0PXT1,

jejuni, Campylobacter jejuni,

Q877L9, Q0SQQ8,

Campylobacter jejuni, Campylobacter

Q8XFP8, Q0TMN0,

jejuni, Campylobacter jejuni,

Q97EH5, A6LPP6,

Clostridium botulinum, Clostridium

A3DJ00, B81I5N8,

botulinum, Clostridium botulinum,

Q839G8, A5GAW4,

Clostridium botulinum, Clostridium

Q748X8, Q39Y08,

botulinum, Clostridium kluyveri,

B5Z8K3, B2UUW8,

Clostridium novyi, Clostridium tetani,

P56003, B6JN44,

Clostridium perfringens, Clostridium

Q17VM8, Q03YI2,

perfringens, Clostridium perfringens,

B1MY04, Q03F25,

Clostridium acetobutylicum,

Q2K9N2, Q2K9L8,

Clostridium beijerinckii, Clostridium

P75022, Q925Y6,

thermocellum, Clostridium

Q1MIE3, Q981F7,

cellulolyticum, Enterococcus faecalis,

A5V604, A8YZP5,

Geobacter uraniireducens, Geobacter

P64029, Q6GBT9,

sulfurreducens, Geobacter

P99152, Q6GJC0,

metallireducens, Helicobacter pylori,

P64028, A6QEK0,

Helicobacter pylori, Helicobacter

Q5HIC7, Q2YSB3,

pylori, Helicobacter pylori,

A5IQA2, Q2G0N0,

Helicobacter acinonychis,

A6TZ25, Q2FJ92,

Leuconostoc mesenteroides,

A7WYX6, Q8CQ81,

Leuconostoc citreum, Pediococcus

Q5HRK4, B9DKV8,

ntosaceus, Rhizobium etli, Rhizobium

Q4L3K9

etli, Rhizobium radiobacter,

Rhizobium meliloti, Rhizobium

leguminosarum, Rhizobium loti,

Sphingomonas wittichii,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus carnosus,

Staphylococcus haemolyticus

777
GTKFDSSLDR

Neisseria meningitidis, Neisseria

P56989, P0A0W2
Q02790

meningitidis

778
GTPDYLAPE

Streptomyces coelicolor

P54740
Q96GX5

779
GTPVLDIKPY

Pseudomonas aeruginosa

Q9RPT0
Q9BU70

780
GTQYRSAIY

Corynebacterium diphtheriae

Q6NEL2
Q9UJ68

781
GTQYRSAIYP

Escherichia coli

B6I2D2
Q9UJ68

782
GTSSLRRAAQL

Listeria monocytogenes, Listeria

B8DHJ2, C1KVK3,
P08397

monocytogenes, Listeria

Q71ZB2, Q8Y6X5,

monocytogenes, Listeria

Q92BF8

monocytogenes, Listeria innocua

783
GTSSRSTKL

Bacillus subtilis, Enterococcus

P18158, O86963,
P43304

casseliflavus, Staphylococcus

Q8CPE6, Q5HPP0,

epidermidis, Staphylococcus

Q4L608, Q2YXR5,

epidermidis, Staphylococcus

Q6GHD4, Q7A105,

haemolyticus, Staphylococcus

Q6G9R2, Q99UH2,

aureus, Staphylococcus aureus,

Q7A5V7, Q2FYZ4,

Staphylococcus aureus,

Q5HGD1, Q2FHD8,

Staphylococcus aureus,

Q49X94, P35596,

Staphylococcus aureus,

P0DB21, P0DB20,

Staphylococcus aureus,

Q8NZX0, Q5XAK0,

Staphylococcus aureus,

Q99YI8

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

784
GTVGAVALD

Escherichia coli

P37595
Q7L266

785
GTVTAANSS

Bacillus subtilis

O07618
P55084

786
GVAHAGWKGT

Bacillus subtilis

O31726
Q8IV20

787
GVDEAGRGP

Acinetobacter baylyi, Bacillus

Q6FCT7, A7Z4M6,
O75792

methylotrophicus, Fusobacterium

Q8RDX3, B8I7T9,

nucleatum, Clostridium cellulolyticum,

B9M597, Q39RP1,

Geobacter daltonii, Geobacter

A1KRM4, Q5F5X9,

metallireducens, Neisseria

Q9K1G1, Q9JX40,

meningitidis, Neisseria gonorrhoeae,

A9M3R5, B2UBB5,

Neisseria meningitidis, Neisseria

Q8XZH7

meningitidis, Neisseria meningitidis,

Ralstonia pickettii, Ralstonia

solanacearum

788
GVENLRVVDASIM

Citrobacter koseri

A8AJN0
Q8NE62

P

789
GVGERTREGND

Neisseria gonorrhoeae, Neisseria

Q5F4Z0, B4RJG0
P06576

gonorrhoeae

790
GVGERTREGNDL

Clostridium novyi, Clostridium

A0Q2Z4, A5N3H7,
P06576

Y

kluyveri, Clostridium botulinum,

A7G909, B1IE34,

Clostridium botulinum, Clostridium

B1KSS8, C1F0P5,

botulinum, Clostridium botulinum,

A7FQH9, C3KYJ3,

Clostridium botulinum, Clostridium

A5HY52, Q9Z687

botulinum, Clostridium botulinum,

Clostridium acetobutylicum

791
GVHRVQRVP

Desulfitobacterium hafniense,

B8FZ76, Q24ML9,
Q9UGC7

Desulfitobacterium hafniense,

B8I562, C3KYH5,

Clostridium cellulolyticum, Clostridium

A3DIL4, A7G9P2,

botulinum, Clostridium thermocellum,

B1IE21, C1F097,

Clostridium botulinum, Clostridium

A5HY35, A7FQG2,

botulinum, Clostridium botulinum,

BlKSR1, Q898Y5,

Clostridium botulinum, Clostridium

A6LQG2, A0Q312,

botulinum, Clostridium botulinum,

B2TJY5, B2UZI5,

Clostridium tetani, Clostridium

B0S2B6, Q98G93,

beijerinckii, Clostridium novyi,

Q92MK5, Q2K3T1,

Clostridium botulinum, Clostridium

B5ZRR4, Q1MBB2,

botulinum, Finegoldia magna,

A5V9C3

Rhizobium loti, Rhizobium meliloti,

Rhizobium etli, Rhizobium

leguminosarum, Rhizobium

leguminosarum, Sphingomonas

wittichii

792
GVHRVQRVPKTE

Fusobacterium nucleatum

Q8R5W0
Q9UGC7

793
GVIINTASV

Clostridium scindens

P19337
Q99714

794
GVKKGDRW

Campylobacter jejuni, Campylobacter

A1W1D6, Q9PMD2,
Q86V21

jejuni, Campylobacter jejuni

A8FNJ7

795
GVLGEHGRG

Geobacter daltonii

B9M8U3
O15269

796
GVLVPGGFG

Clostridium perfringens, Clostridium

Q0SQX5, Q0TNA4,
P17812

perfringens, Clostridium perfringens,

Q8XIB3, C6BWN7

Desulfovibrio salexigens

797
GVMLRGSGI

Campylobacter jejuni, Campylobacter

A7H5S8, A8FNN4,
O75306

jejuni, Campylobacter jejuni,

A1W1H5, Q5HSL5,

Campylobacter jejuni, Campylobacter

Q9PM99

jejuni

798
GVPFNIASYAL

Clostridium cellulolyticum

B8I0T8
P04818

799
GVPIIADGGI

Bacillus halodurans

Q9KGN8
P20839

800
GWDAFGLPAE

Citrobacter koseri, Edwardsiella

A8AJG0, C5BGC7,
O15031

ictaluri, Enterobacter sp., Escherichia

A4W827, A7ZJ31,

coli, Escherichia coli, Escherichia coli,

B1LL91, Q1RER9,

Escherichia coli, Escherichia coli,

A1A8R7, B7MFR5,

Escherichia coli, Escherichia coli,

A7ZXR8, B1IYG6,

Escherichia coli, Escherichia coli,

B7UKT2, P07813,

Escherichia coli, Escherichia coli,

C4ZWC9, B7NM01,

Escherichia coli, Escherichia

Q0TK31, B7LLH1,

fergusonii, Escherichia coli,

B7M5G9, B7L9I6,

Escherichia coli, Escherichia coli,

B6I153, Q8FJY9,

Escherichia coli, Escherichia coli,

B7MRS9, B5YQJ4,

Escherichia coli, Escherichia coli,

Q8XBN8, B7N9P8,

Escherichia coli, Klebsiella

A6T6A3, B5XZR2,

pneumoniae, Klebsiella pneumoniae,

B4EV14

Proteus mirabilis

801
GWDCHGLPVE

Propionibacterium acnes,

Q6AB89, Q9S2X5,
P41252

Streptomyces coelicolor,

Q82AC9

Streptomyces avermitilis

802
GWKEIEYEV

Eubacterium rectale, Clostridium

C4ZEK2, Q8XHB3,
P31327

perfringens, Clostridium perfringens,

Q0SPY4, Q0TM79,

Clostridium perfringens, Clostridium

A7GE89, C1FNY3,

botulinum, Clostridium botulinum,

B1KT07, B2UX86,

Clostridium botulinum, Clostridium

B2THH3, A9KI94

botulinum, Clostridium botulinum,

Clostridium phytofermentans

803
GWKKNGWKT

Rhizobium loti, Rhizobium

Q985W1, Q1MKH6
O60930

leguminosarum

804
GWKKNGWKTS

Rhizobium etli

Q2KBL2
O60930

805
GWLHTGDIG

Bacillus cereus

Q72YK9
Q9ULC5

806
GWYMGTEIG

Bacillus subtilis

O34453
P29475

807
GYEEAAAQG

Clostridium thermocellum,

A3DHY7, A1VD34,
Q9Y2Z2

Desulfovibrio vulgaris, Desulfovibrio

Q72B11

vulgaris

808
GYGGPHAAFFA

Pseudomonas aeruginosa

Q9HTX7
P23378

809
GYGIRYEYG

Haemophilus influenzae

P45180
P06737

810
GYLGAGKTTLLN

Bacillus subtilis

P94400
Q5RIA9

811
GYLHIGHAK

Citrobacter koseri, Clostridium

A8AJD6, A5N6Y3,
P07814

kluyveri, ptoclostridium difficile,

Q188C8, Q8XMP3,

Clostridium perfringens, Clostridium

Q0SVB1, Q0TTG1,

perfringens, Clostridium perfringens,

C5BGA4, A4W846,

Edwardsiella ictaluri, Enterobacter

B7NMN1, B6HYN9,

sp., Escherichia coli, Escherichia coli,
P00962, B1IY48,

Escherichia coli, Escherichia coli,

B1X6L3, A7ZXU0,

Escherichia coli, Escherichia coli,

C4ZWF6, B7M5J8,

Escherichia coli, Escherichia coli,

B7L9L7, A7ZJ63,

Escherichia coli, Escherichia coli,

B7LKT3, B1LLC4,

Escherichia fergusonii, Escherichia

B7N9S6, Q1REN7,

coli, Escherichia coli, Escherichia coli,

Q8FJW4, Q0TK03,

Escherichia coli, Escherichia coli,

A1A8U7, B7MPI5,

Escherichia coli, Escherichia coli,

B7MFU7, B7UKW1,

Escherichia coli, Escherichia coli,

B5YQM4, Q8X9H8,

Escherichia coli, Escherichia coli,

Q7VLM3, Q40K64,

Haemophilus ducreyi, Haemophilus

P43831, B5XZG7,

influenzae, Haemophilus influenzae,

A6T6C3, Q5F7G0,

Klebsiella pneumoniae, Klebsiella

P57000, P56927,

pneumoniae, Neisseria gonorrhoeae,

B4EV71, Q9I2U8,

Neisseria meningitidis, Neisseria

Q02KT5, B7VB85,

meningitidis, Proteus mirabilis,

A4XVG2, Q87YQ1,

Pseudomonas aeruginosa,

Q88IU5, A4VL72,

Pseudomonas aeruginosa,

Q8Y199, B2U846

Pseudomonas aeruginosa,

Pseudomonas mendocina,

Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

stutzeri, Ralstonia solanacearum,

Ralstonia pickettii

812
GYLSDRFGR

Bacillus subtilis

O31762
Q9Y694

813
GYSVFAGVGERT

Aeromonas hydrophila, Aeromonas

A0KQX8, A4STP3,
P06576

REGND

salmonicida, Citrobacter koseri,

A8ACN6, C5BF40,

Edwardsiella ictaluri, Enterobacter

A4WGF5, A8A6J5,

sp., Escherichia coli, Escherichia coli,
B1IX06, B7UMJ7,

Escherichia coli, Escherichia coli,

P0ABB4, B7LK77,

Escherichia fergusonii, Escherichia

B1LL59, A1AHR4,

coli, Escherichia coli, Escherichia coli,

B1X9W0, C4ZZ10,

Escherichia coli, Escherichia coli,

B7NR34, B7NF48,

Escherichia coli, Escherichia coli,

B5YXD6, B7M588,

Escherichia coli, Escherichia coli,

Q1R4K2, B6I3W9,

Escherichia coli, Escherichia coli,

B7N2H1, Q0TAX7,

Escherichia coli, Escherichia coli,

P0ABB5, P0ABB6,

Escherichia coli, Escherichia coli,

B7MGF2, B7L882,

Escherichia coli, Escherichia coli,

A7ZTU4, B8F774,

Haemophilus parasuis, Haemophilus

Q0I5X3, Q7VPP0,

somnus, Haemophilus ducreyi,

A5UA11, Q40N64,

Haemophilus influenzae,

P43715, A5UGY9,

Haemophilus influenzae,

B5XZM4, A6TG36,

Haemophilus influenzae,

B4F0E7, C3K1E6,

Haemophilus influenzae, Klebsiella

B1JFU1, Q4ZL24,

pneumoniae, Klebsiella pneumoniae,

Q87TT4, Q48BG5,

Proteus mirabilis, Pseudomonas

A4VS62, B0KRA8,

fluorescens, Pseudomonas putida,

Q3K441, A5WBA3,

Pseudomonas syringae,

Q88BX4, Q02DF4,

Pseudomonas syringae,

A6VF32, Q9HT20,

Pseudomonas savastanoi,

B7V791, Q4K3A9,

Pseudomonas stutzeri, Pseudomonas

Q1I2I7, A4Y187

putida, Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas entomophila,

Pseudomonas mendocina

814
GYSVFAGVGERT

Helicobacter pylori, Helicobacter

Q9ZK81, B6JMX2,
P06576

REGNDLY

pylori, Helicobacter pylori,

B5Z8D0, P55988,

Helicobacter pylori, Helicobacter

Q1CSD5, Q17Y78

pylori, Helicobacter acinonychis

815
GYSVFAGVGERT

Helicobacter hepaticus

Q7VJ21
P06576

REGNDLYHEM

816
GYTGEDGVE

Neisseria meningitidis, Neisseria

Q9K0L8, Q9JVP2
P48728

meningitidis

817
GYTKDYPVE

Bacillus subtilis

P45867
P45954

818
HARGPVGLEGL

Pseudomonas fluorescens,

Q4K5F9, A4VR07,
P54886

Pseudomonas stutzeri, Pseudomonas

B7V8A7, C3K2M9,

aeruginosa, Pseudomonas

Q02SH4, Q9HX20,

fluorescens, Pseudomonas

A6V0A3, A4XYY4,

aeruginosa, Pseudomonas

Q1I4F0, B1J133,

aeruginosa, Pseudomonas

Q4ZN73, A5W9J6,

aeruginosa, Pseudomonas

Q87W6, Q88DL4,

mendocina, Pseudomonas

B0KJY5, Q48DL4,

entomophila, Pseudomonas putida,

Q8XVT6, B2UC98

Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

syringae, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

savastanoi, Ralstonia solanacearum,

Ralstonia pickettii

819
HDGPPYANG

Campylobacter fetus

A0RNK3
Q9NSE4

820
HDLGHGPFSH

Bacillus subtilis

P39651
Q9Y3Z3

821
HEIGHTLGL

Proteus mirabilis, Pseudomonas

Q11137,
Q9H239

panacis, Pseudomonas aeruginosa

A0A0C5CJR8, Q03023

822
HEWEKHGTC

Aeromonas hydrophila

Q07465
O00584

823
HFDRERIPERVVH

Bacillus subtilis

P94377
P04040

A

824
HFPLVVWQTGSG

Bacillus cereus, Bacillus anthracis,

Q81F85, Q81SA0,
P07954

TQ

Listeria monocytogenes, Listeria

Q71XE0, Q929E8,

innocua, Listeria monocytogenes,

Q8Y551, Q92PB6,

Rhizobium meliloti, Staphylococcus

Q6GFK5, Q5HE54,

aureus, Staphylococcus aureus,

Q49YP8, Q4L7F5,

Staphylococcus saprophyticus,

Q8NW1, Q6G884,

Staphylococcus haemolyticus,

P64173, P64172

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

825
HFPLVVWQTGSG

Pseudomonas aeruginosa

Q9I587
P07954

TQTNMNVNEVI

826
HFTSPIRRY

Escherichia coli, Haemophilus

P21499, P44907
Q8TF46

influenzae

827
HGALYHSQS

Bacillus subtilis

P37941
P21953

828
HGATGKGNDQ

Rhizobium leguminosarum

Q1MEZ8
P00966

829
HGDGYPFDG

Tannerella forsythia

D0EM77
P14780

830
HGIPFYVAAP

Desulfitobacterium hafniense,

B8FRM1, Q24UA0,
Q9BV20

Desulfitobacterium hafniense,

A8ANI3, Q317L9,

Citrobacter koseri, Desulfovibrio

A4W7Z1, B3E3M5

alaskensis, Enterobacter sp.,

Geobacter lovleyi

831
HGSDSVESA

Enterobacter sp., Escherichia coli,
A4W096, B7MYF2,
Q13232

Escherichia coli, Escherichia coli,

B7UGW4, B6I590,

Escherichia coli, Escherichia

P0A764, B7LKC0,

fergusonii, Escherichia coli,

B7M7M2, A8A324,

Escherichia coli, Escherichia coli,

P0A763, B1IWE3,

Escherichia coli, Escherichia coli,

B7N6A6, B7LDB0,

Escherichia coli, Escherichia coli,

C4ZX93, B5Z0Y7,

Escherichia coli, Escherichia coli,

B1XAZ3, A7ZPW1,

Escherichia coli, Escherichia coli,

Q8FF53, Q1R8L4,

Escherichia coli, Escherichia coli,

B7MI03, B1LNH3,

Escherichia coli, Escherichia coli,

Q0TEW7, A1AE56,

Escherichia coli, Escherichia coli,

B7NRG8, B5XNL1,

Klebsiella pneumoniae, Klebsiella

A6TCD7

pneumoniae

832
HGSTYGGNPL

Campylobacter jejuni, Escherichia

Q9PIR7, Q8X4S6,
P04181

coli, Escherichia coli, Escherichia coli,

P59317, P18335,

Rhizobium meliloti

Q92SA0

833
HGTAPDIAG

Streptococcus mutans

Q59940
P50213

834
HHPEWFNVY

Rhizobium leguminosarum,

Q1MAM8, B5ZTF5,
P61457

Rhizobium leguminosarum,

Q2K3A7

Rhizobium etli

835
HHPEWFNVYNKV

Rhizobium sp., Rhizobium meliloti
C3MAI8, Q92L66
P61457

836
HHTFFEMLG

Bacillus halodurans, Bacillus

Q9KDE6, Q65GS5,
P49588

licheniformis, Bacillus subtilis,

O34526, Q38YN9,

Lactobacillus sakei, Bacillus

A7GT67, Q817Z0,

cytotoxicus, Bacillus cereus, Bacillus

P61697, A8FFM9,

cereus, Bacillus pumilus, Bacillus

Q634F6, A0RJ00,

cereus, Bacillus thuringiensis, Bacillus

A9VI09, Q81LK0,

weihenstephanensis, Bacillus

Q6HDD7, Q5WHM8,

anthracis, Bacillus thuringiensis,

A7Z735, Q24UT2,

Bacillus clausii, Bacillus

Q8RFJ8, Q30YS5,

methylotrophicus, Desulfitobacterium

A1VEQ6, P61700,

hafniense, Fusobacterium nucleatum,

P43815, Q92BK9,

Desulfovibrio alaskensis,

Q71ZG6, A0AIV3,

Desulfovibrio vulgaris, Desulfovibrio

Q8Y722, Q49Y56,

vulgaris, Haemophilus influenzae,

P67011, P67010,

Listeria innocua, Listeria

A5ITE3, A7X328,

monocytogenes, Listeria welshimeri,

A6U287, Q8NW87,

Listeria monocytogenes,

Q6G8V1, Q2YT60,

Staphylococcus saprophyticus,

A8Z4F6, A6QHF9,

Staphylococcus aureus,

Q2FXV9, Q5HFE4,

Staphylococcus aureus,

Q2FGA8, Q6GG85,

Staphylococcus aureus,

Q8CSA7, Q5HNT2,

Staphylococcus aureus,

Q4L6W5

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus

837
HIDMDAFYA

Acinetobacter baylyi, Bacteroides

Q6FFG4, Q64X95,
Q9UBT6

fragilis, Clostridium perfringens,

Q8XK37, Q0SSQ2,

Clostridium perfringens,

Q18A91, Q0TQ38,

ptoclostridium difficile, Clostridium

Q71Y46, Q8Y5T0,

perfringens, Listeria monocytogenes,

C1KWR9, Q92A40,

Listeria monocytogenes, Listeria

B8DBV7, A0AK80,

monocytogenes, Listeria innocua,

Q9JY58, A1KUQ3,

Listeria monocytogenes, Listeria

Q9JRG1, Q5F8N2,

welshimeri, Neisseria meningitidis,

Q92XH8

Neisseria meningitidis, Neisseria

meningitidis, Neisseria gonorrhoeae,

Rhizobium meliloti

838
HKMAEANRA

Propionibacterium acnes, Clostridium

Q6A6L4, B8I5N6,
Q9Y2R9

cellulolyticum, Corynebacterium

A4QBG8, Q8NT20,

glutamicum, Corynebacterium

B1VES9, Q4JT38,

glutamicum, Corynebacterium

C4LL65, A5GAY4,

urealyticum, Corynebacterium

B9M6U9, B3E7T1,

jeikeium, Corynebacterium

B5EFP6, C6E4R1,

kropnstedtii, Geobacter

B1MW22, Q03ZQ3,

uraniireducens, Geobacter daltonii,

Q98N60

Geobacter lovleyi, Geobacter

bemidjiensis, Geobacter sp.,

Leuconostoc citreum, Leuconostoc

mesenteroides, Rhizobium loti

839
HLGHVFPDGP

Lactobacillus plantarum, Desulfovibrio

Q88W33, Q72EK2,
Q9Y3D2

vulgaris, Listeria monocytogenes,

C1KWF8, Q71YF7,

Listeria monocytogenes, Listeria

Q8Y641, Q92AE9,

monocytogenes, Listeria innocua,

B8DDP3, A0AJW4,

Listeria monocytogenes, Listeria

P14930, Q9JWM8,

welshimeri, Neisseria gonorrhoeae,

Q9K1N8, Q92Y46

Neisseria meningitidis, Neisseria

meningitidis, Rhizobium meliloti

840
HLGHVFPDGPGP

Bacillus licheniformis

Q65ID2
Q9Y3D2

841
HLGHVFPDGPGP

Bacillus clausii, Bacillus halodurans,

Q5WH73, Q9KCX2,
Q9Y3D2

NG

Bacillus pumilus

A8FEA3

842
HLLGTHDFSAF

Bacillus clausii

Q5WLN0
Q8NOZ8

843
HMGITAENVA

Rhizobium meliloti

P50174
Q9BWD1

844
HNERLEFLGD

Edwardsiella ictaluri, Enterobacter

C5B8Y2, A4WDD8,
Q9NRR4

sp., Escherichia fergusonii,
B7LUZ7, B7N6F5,

Escherichia coli, Escherichia coli,

Q1R8G6, B1LP80,

Escherichia coli, Escherichia coli,

A8A377, B6I5E1,

Escherichia coli, Escherichia coli,

P0A7Y0, B1IVR0,

Escherichia coli, Escherichia coli,

B1X1341, P0A7Y1,

Escherichia coli, Escherichia coli,

Q0TES1, A1AE97,

Escherichia coli, Escherichia coli,

C4ZYJ0, B7NRM0,

Escherichia coli, Escherichia coli,

B7M810, B7MYJ8,

Escherichia coli, Escherichia coli,

B5Z141, P0A7Y2,

Escherichia coli, Escherichia coli,

B7LDG0, A7ZQ11,

Escherichia coli, Escherichia coli,

B7MIQ2, B7UH07,

Escherichia coli, Haemophilus

Q4QPN0, A5UBC4,

influenzae, Haemophilus influenzae,

P44441, A5UFI8,

Haemophilus influenzae,

A6TCI1, B5XNH0,

Haemophilus influenzae, Klebsiella

B4F047, Q8Y0I1,

pneumoniae, Klebsiella pneumoniae,

B2U981

Proteus mirabilis, Ralstonia

solanacearum, Ralstonia pickettii

845
HNERLEFLGDA

Streptococcus thermophilus,

Q5M3S3, Q5LZ68,
Q9NRR4

Streptococcus thermophilus,

Q03K17

Streptococcus thermophilus

846
HNERLEFLGDAV

Desulfovibrio vulgaris, Desulfovibrio

Q72C44, B8DPB3,
Q9NRR4

vulgaris, Staphylococcus aureus,

Q2YXI3, Q931T1,

Staphylococcus aureus,

A7X1J9, P66669,

Staphylococcus aureus,

Q6G9Y0, A8Z3R9,

Staphylococcus aureus,

Q6GHK2, A6QGD3,

Staphylococcus aureus,

P66668, Q5HGJ9,

Staphylococcus aureus,

A5ISB8, Q2FZ50,

Staphylococcus aureus,

A6U152, Q2FHK5,

Staphylococcus aureus,

Q8CPI1, Q5HPV8,

Staphylococcus aureus,

Q4L5T5, B9DPJ2,

Staphylococcus aureus,

Q49X17, A8AWC2,

Staphylococcus aureus,

Q8E0K7, Q8E680,

Staphylococcus aureus,

Q3K1Y2, C0MCR4,

Staphylococcus aureus,

A3CP46, C0M8Y3,

Staphylococcus aureus,

C10EK4, B2IPN5,

Staphylococcus epidermidis,

C1C7M6, C1CR56,

Staphylococcus epidermidis,

Q97QG6, Q8DPJ8,

Staphylococcus haemolyticus,

B5E4Y2, Q04K72,

Staphylococcus carnosus,

C1CKY7, B8ZJR8,

Staphylococcus saprophyticus,

B1IC43, B9DRH1,

Streptococcus gordonii,

P0DF15, Q1J7V3,

Streptococcus agalactiae,

Q1JMX4, Q1JCZ9,

Streptococcus agalactiae,

P66672, P0DF14,

Streptococcus agalactiae,

P66670, Q48UR6,

Streptococcus equi, Streptococcus

B5XKB7, A2RFW8,

sanguinis, Streptococcus equi,

Q5XDA6, Q1JI19,

Streptococcus pneumoniae,

Q8DT66

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus uberis, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans

847
HNPTGIDPT

Escherichia coli

P00509
P17174

848
HPDIKAISFVGS

Bacillus methylotrophicus, Bacillus

clausii

A7ZAI1, Q5WKZ1
O02252

849
HPDLRRILTDYGF

Ralstonia solanacearum, Ralstonia

Q8XXQ3, B2U7Q9,
O75489

pickettii, Stenotrophomonas

B2FNX7, B45QT4

maltophilia, Stenotrophomonas

maltophilia

850
HPDLRRILTDYGF

Rhizobium meliloti

O68854
O75489

EG

851
HPDLRRILTDYGF

Rhizobium etli, Rhizobium etli,

B3PVZ9, Q2K9T3,
Q75489

EGHP

Rhizobium leguminosarum,

B5ZYL4, Q1MIL3

Rhizobium leguminosarum

852
HPDRNPDDP

Desulfovibrio vulgaris, Desulfovibrio

A1V9Q3, Q725M6
Q9UB54

vulgaris

853
HPESYHSFM

Haemophilus influenzae,

Q4QP46, P44538,
P46926

Haemophilus influenzae,

A5UB10

Haemophilus influenzae

854
HPFPGPGLA

Helicobacter pylori

B5Z842
P49915

855
HPHRGFETV

Pseudomonas aeruginosa,

Q9HZ00, Q9I163
O00625

Pseudomonas aeruginosa

856
HPLAGQGVN

Escherichia coli, Escherichia coli

P75728, P25535
Q9Y2Z9

857
HQTGHNSGVIH

Escherichia coli

P37339
Q9H9P8

858
HRDIKPENIL

Bifidobacterium longum

Q8G4G1
Q8IVW4

859
HRDIKPGNIM

Bifidobacterium longum

Q8G6P9
Q14164

860
HRFAAYFQQG

Klebsiella oxytoca

P77877
P06744

861
HRGRLNVLA

Bacillus subtilis, Bacillus licheniformis,

P23129, Q65IH4,
Q9ULD0

Bacillus pumilus, Bacillus

A8FE66, A7Z5J9

methylotrophicus

862
HRSHIDYLLL

Haemophilus somnus, Haemophilus

Q0I2G8, A5UHQ2,
Q9HCL2

influenzae, Haemophilus influenzae,

Q4QMF0, A5UDX7,

Haemophilus influenzae,

P44857, Q4KHJ1,

Haemophilus influenzae,

Q48F46, Q3KHC9,

Pseudomonas fluorescens,

C3K4R1, Q886Q7,

Pseudomonas savastanoi,

B1JBS6, A4XWX9,

Pseudomonas fluorescens,

A6V1B5, Q02RE5,

Pseudomonas fluorescens,

B0KS79, Q9HXW7,

Pseudomonas syringae,

B7V2U0, Q4ZWU3,

Pseudomonas putida, Pseudomonas

Q1I610, Q88MQ0,

mendocina, Pseudomonas

A5W867

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas putida,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas syringae,

Pseudomonas entomophila,

Pseudomonas putida, Pseudomonas

putida

863
HRVQRVPKTE

Haemophilus parasuis, Haemophilus

B8F526, Q4QKS1,
Q9UGC7

influenzae, Haemophilus influenzae,

P43917, Q013135,

Haemophilus somnus, Haemophilus

Q7VMV9, Q888C1

ducreyi, Pseudomonas syringae

864
HTGDSVVVAP

Staphylococcus carnosus

B9DPN2
P31327

865
HTGRSRNDQV

Desulfitobacterium hafniense,

Q24ZG7, B8FWX3
P04424

Desulfitobacterium hafniense

866
HTNFSTKAMRE

Streptomyces viridochromogenes

P19432
P15104

867
HTNGSQFFI

Staphylococcus saprophyticus

Q49W93
P30414

868
HTVCEEARCPNI

Bacillus clausii

Q5WDS6
O43766

869
HVRGGGELG

Escherichia coli, Rhizobium sp.,
P24555, P55656,
Q4J6C6

Rhizobium sp.
P55627

870
HVSTGGGASLE

Finegoldia magna

B0S1H0
P07205

871
IAAGEVIQRPA

Parabacteroides distasonis,

A6LEJ8, Q8A120,
P40692

Bacteroides thetaiotaomicron,

Q5L8M5, Q64NX1,

Bacteroides fragilis, Bacteroides

A6KXH3, B2RL29,

fragilis, Bacteroides vulgatus,

Q7MX15

Porphyromonas gingivalis,

Porphyromonas gingivalis

872
IAATNRPDVLD

Haemophilus influenzae

P45219
Q9BVQ7

873
IACGTSYHAG

Acinetobacter baylyi, Bacillus

Q6F6U8, Q65P46,
Q06210

licheniformis, Bacillus cereus, Bacillus

Q81J01, Q6HPL2,

thuringiensis, Bacillus anthracis,

Q81VN5, Q73F49

Bacillus cereus

874
IADVGLVGFPN

Clostridium phytofermentans

A9KMF5
A4D1E9

875
IAHRLSTIQ

Streptococcus pneumoniae

P35598
O95342

876
IAHVDHGKSTL

Stenotrophomonas maltophilia,

B2FQC4, B4SRL3
P13639

Stenotrophomonas maltophilia

877
IAREMNLSE

Pseudomonas fluorescens

Q51792
P30039

878
IAREMNLSET

Pseudomonas chlororaphis

Q51520
P30039

879
IATGHYART

Geobacter uraniireducens

A5GE36
O75648

880
IAVGSDADIV

Ralstonia pickettii

Q8VTT5
Q14117

881
IAVLTSGGDA

Clostridium botulinum, Clostridium

B1L266, C3KV06,
P08237

botulinum, Clostridium botulinum,

A5I798, A7GIW9,

Clostridium botulinum, Clostridium

C1FM55, B1IFV9,

botulinum, Clostridium botulinum,

A7FYW7, Q8XNH2,

Clostridium botulinum, Clostridium

O08308, Q0I267,

perfringens, Clostridium

B9DN94, A4VTS0,

acetobutylicum, Haemophilus

A3CM69, B5E3Z8,

somnus, Staphylococcus carnosus,

B1IB66, C1C6M8,

Streptococcus suis, Streptococcus

A8AXW1, C1CRZ7,

sanguinis, Streptococcus

C1CJY4, C1CDP4,

pneumoniae, Streptococcus

Q97RC6, B8ZNU0,

pneumoniae, Streptococcus

62IP53, Q8DQ85,

pneumoniae, Streptococcus gordonii,

Q04L24, P65696,

Streptococcus pneumoniae,

P65697, Q3K1E6,

Streptococcus pneumoniae,

C0M8V6, B4U2M2,

Streptococcus pneumoniae,

C0MGJ9, P0DD03,

Streptococcus pneumoniae,

P0DD02, 65XLV6,

Streptococcus pneumoniae,

A2RE65, Q1JGH6,

Streptococcus pneumoniae,

Q48T86, Q1JLD9,

Streptococcus pneumoniae,

Q8P056, Q1J6F7,

Streptococcus pneumoniae,

Q5X6V2, Q99ZD0,

Streptococcus agalactiae,

B9DSA4

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus equi, Streptococcus

equi, Streptococcus equi,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus uberis

882
ICPVGALTS

Streptomyces coelicolor

Q9XAR0
P28331

883
IDGLIVTNTT

Acinetobacter baylyi, Acinetobacter

Q6FCL9, B7GZW7,
Q02127

baumannii, Acinetobacter baumannii,

A3M6Y2, 67I2L5,

Acinetobacter baumannii,

B2HUT6, B0V824,

Acinetobacter baumannii,

B0VKB8

Acinetobacter baumannii,

Acinetobacter baumannii

884
IDLAIDGADEVD

Staphylococcus epidermidis,

Q8CRC8, Q5HLQ9,
P49247

Staphylococcus epidermidis,

Q5HDM1, Q6GE99,

Staphylococcus aureus,

P66696, Q6G6Y5,

Staphylococcus aureus,

P66694, P66695

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

885
IDLIIPRGS

Clostridium thermocellum, Clostridium

A3DC22, B8I6T0
P54886

cellulolyticum

886
IDQLKPGGRL

Geobacter sulfurreducens

Q74CZ5
P22061

887
IDTCQGDSGGP

Streptomyces glaucescens

Q54179
P10323

888
IDTGMGLER

Lactobacillus johnsonii, Lactobacillus

P61702, Q045P6,
P49588

gasseri, Lactobacillus acidophilus,

Q5FLW6, A8YTJ0,

Lactobacillus helveticus, Lactobacillus

Q03R43, Q1WT32,

brevis, Lactobacillus salivarius,

Q0TPH4, Q0SS42,

Clostridium perfringens, Clostridium

Q8XJH6, Q97IG3,

perfringens, Clostridium perfringens,

Q835J8, Q03ER8

Clostridium acetobutylicum,

Enterococcus faecalis, Pediococcus

ntosaceus

889
IDTGMGLERLV

Lactobacillus casei

Q03B02
P49588

890
IDTPGHVDFT

Clostridium tetani, Clostridium

Q890N8, A9KRZ3,
Q96RP9

phytofermentans, Corynebacterium

B1VET0

urealyticum

891
IDTPGHVDFTIEVE

Campylobacter jejuni, Campylobacter

A7H4P5, Q5HVX6,
Q96RP9

R

jejuni, Campylobacter jejuni,

Q9PI16, A8FKR7,

Campylobacter jejuni, Campylobacter

A0RQI0, A1VYJ8,

fetus, Campylobacter jejuni,

A7I3T6, B9KFH1,

Campylobacter hominis,

A8Z6I6, A7GZJ4,

Campylobacter lari, Campylobacter

Q9ZK24, P56002,

concisus, Campylobacter curvus,

B2UUV6, Q17VN9,

Helicobacter pylori, Helicobacter

B5Z8J0, Q1CS71,

pylori, Helicobacter pylori,

B6JN34, Q7VJ85

Helicobacter acinonychis,

Helicobacter pylori, Helicobacter

pylori, Helicobacter pylori,

Helicobacter hepaticus

892
IDVWEHAYYL

Bacillus cereus, Bacillus anthracis

Q814I6, Q81JK8
P04179

893
lEAHGTGTK

Bacillus subtilis

Q9R9J1
P49327

894
IFITHLHGDH

Bacillus clausii, Bacillus halodurans

Q5WGC3, Q9KC61
Q9H777

895
IFLRELISNASDA

Geobacter sulfurreducens

P61185
P14625

896
IGGADMPW

Escherichia coli, Escherichia coli,

P0AB69, P0AB67,
Q13423

Escherichia coli, Haemophilus

P0AB68, P43010

influenzae

897
IGGDGSLTGA

Bacteroides thetaiotaomicron,

Q8A624, Q8A8R5
Q01813

Bacteroides thetaiotaomicron

898
IGGGMAYTFLK

Bifidobacterium adolescentis,

A1A1N3, B1W0Z3,
P07205

Streptomyces griseus, Streptomyces

Q9Z519, Q829W2

coelicolor, Streptomyces avermitilis

899
IGIAMGSGT

Escherichia coli

P37617
Q14983

900
IGIGGSDLGP

Neisseria meningitidis, Neisseria

Q9JSS6, Q5F694,
P06744

gonorrhoeae, Neisseria meningitidis

Q9K153

901
IGKAGRNRW

Streptococcus agalactiae,

Q8E2C8, Q8E7T5,
Q5T653

Streptococcus agalactiae,

Q3K3W6

Streptococcus agalactiae

902
IGKAGRNRWLGK

Desulfovibrio maeticus

C4XLX6
Q5T653

RP

903
IGKGFQGVMKRW

Geobacter uraniireducens

A5GAW5
P09001

GFKG

904
IGLAVMGQNLILN

Haemophilus ducreyi

Q7VMX4
P52209

MND

905
IGLAVMGQNLILN

Aggregatibacter

P70718, P43774
P52209

MNDHGF

actinomycetemcomitans,

Haemophilus influenzae

906
IGMPHRGRLN

Corynebacterium glutamicum

Q8NRC3
Q96HY7

907
IGSGGREHT

Bacillus halodurans

Q9KF52
P22102

908
IGSGPGGYVAAI

Rhizobium etli

O05940
P09622

909
IGSPPGYVG

Clostridium acetobutylicum

Q97KG0
Q9H078

910
IGSPPGYVGHEE

Bacillus subtilis

O31673
Q9H078

911
IGVLTSGGD

Bacillus halodurans, Bacillus clausii,

Q9K843, Q5WEF6,
Q01813

Bacillus licheniformis, Bacillus

Q65G82, A8FG55,

pumilus, Bacillus subtilis, Bacillus

O34529, Q4MVY3,

cereus, Bacillus cereus, Bacillus

B9J099, Q6HCT3,

thuringiensis, Bacillus cereus, Bacillus

Q72ZD8, Q633J8,

cereus, Bacillus cereus, Bacillus

B7HRN9, C1EUU3,

cereus, Bacillus anthracis, Bacillus

Q81KZ0, A0RJJ6,

thuringiensis, Bacillus cereus, Bacillus

B7JRX2, C3L8X8,

anthracis, Bacillus anthracis, Bacillus

C3PAI8, A7Z7K6,

methylotrophicus, Bacillus

A9VJR1, B7HFB3,

weihenstephanensis, Bacillus cereus,

B7IJZ8, Q817F3,

Bacillus cereus, Bacillus cereus,

A7GTP4, Q9FC99

Bacillus cytotoxicus, Streptomyces

coelicolor

912
IGVLTSGGDA

Citrobacter koseri, Edwardsiella

A8AL13, C5BC26,
Q01813

ictaluri, Enterobacter sp.,
A4WG81, Q9Z6C3,

Enterobacter cloacae, Escherichia

P0A796, A8A720,

coli, Escherichia coli, Escherichia coli,

Q0TAE8, B6I4Q8,

Escherichia coli, Escherichia coli,

B1LNL9, B7N2Q7,

Escherichia coli, Escherichia coli,

B7NFL3, A7ZUC9,

Escherichia coli, Escherichia coli,

B1IVG3, B1X1382,

Escherichia coli, Escherichia coli,

B7NU91, B5YZ53,

Escherichia coli, Escherichia coli,

B7LA13, C5A083,

Escherichia coli, Escherichia coli,

B7M6W7, P0A797,

Escherichia coli, Escherichia coli,

B7MI48, B7LVC9,

Escherichia fergusonii, Escherichia

Q8FBD0, B7UNN6,

coli, Escherichia coli, Klebsiella

B5XZ40, A6TGB8

pneumoniae, Klebsiella pneumoniae

913
IHARGPVGLEGL

Acinetobacter baylyi, Acinetobacter

Q6FEN5, B0VKT1,
P54886

baumannii, Acinetobacter baumannii,

B2I3D3, B0V4S6,

Acinetobacter baumannii,

B7H081, B7I5F5,

Acinetobacter baumannii,

A3M1Z8

Acinetobacter baumannii,

Acinetobacter baumannii

914
IHDAVRPFV

Rhizobium loti

Q98MX9
A4D126

915
IHDAVRPFVE

Bifidobacterium longum,

B7GMX1, Q8G7E2,
A4D126

Bifidobacterium longum,

B3DTQ9

Bifidobacterium longum

916
IHGSDSVESA

Staphylococcus haemolyticus,

Q4L6H1, Q49XS3,
Q13232

Staphylococcus saprophyticus,

B9DNV3

Staphylococcus carnosus

917
IIEPTSGNTGIGLA

Bacillus subtilis, Streptococcus

O34476, Q5XAQ3
P35520

pyogenes

918
IIFTSGGTE

Bacillus subtilis

O34599
Q96I15

919
IIGGGMAFTFLK

Geobacter metallireducens,

Q39U98, C6E770,
P00558

Geobacter sp., Geobacter
B5EF40, A5G382,

bemidjiensis, Geobacter

B9M2C3

uraniireducens, Geobacter daltonii

920
IILDEPTAG

Bacillus cereus, Bacillus anthracis

Q81CT8, Q81PZ8
Q9BZC7

921
IILLDEATSALD

Lactobacillus plantarum

Q88YK7
Q9NP58

922
IIPWNFPLLM

Pseudomonas fluorescens

O06837
O94788

923
IITGPNMGGKST

Acinetobacter baumannii,

B0VAU7, B2HX50,
P43246

Acinetobacter baumannii,

B7IBV9, B7GW85,

Acinetobacter baumannii,

B0VUC9, Q6FC54

Acinetobacter baumannii,

Acinetobacter baumannii,

Acinetobacter baylyi

924
IITGPNMGGKSTY

Aeromonas salmonicida, Aeromonas

A4SIL2, A0KPG5,
P43246

hydrophila, Citrobacter koseri,

A8ANU8, A4WDU5,

Enterobacter sp., Escherichia coli,

B1LQ55, B7NT79,

Escherichia coli, Escherichia coli,

B6I6B9, Q8FEL3,

Escherichia coli, Escherichia coli,

A7ZQH3, B7MYN6,

Escherichia coli, Escherichia coli,

Q0TEC9, Q1R7W4,

Escherichia coli, Escherichia coli,

A1AES5, B7MKK5,

Escherichia coli, Escherichia

B7LWH8, B7N6W4,

fergusonii, Escherichia coli,

B7LEE7, B7LXE0,

Escherichia coli, Escherichia coli,

B5Z397, Q9S6P8,

Escherichia coli, Escherichia coli,

B7UHE9, P23909,

Escherichia coli, Escherichia coli,

B1IUU6, A8A3L2,

Escherichia coli, Escherichia coli,

B1XCR0, C4ZZN7,

Escherichia coli, Escherichia coli,

Q4QML2, A5UE20,

Haemophilus influenzae,

Q0I1B8, B5XV49,

Haemophilus influenzae,

A6TD24, B4F220,

Haemophilus somnus, Klebsiella

Q87XW6, Q1I659,

pneumoniae, Klebsiella pneumoniae,

A5W816, B1JB25,

Proteus mirabilis, Pseudomonas

Q88ME7, B0KSD2

syringae, Pseudomonas entomophila,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas putida

925
IlYTSGTTG

Bacillus weihenstephanensis, Bacillus

A9VM74, B7JDD6,
Q4G176

cereus, Bacillus cereus, Bacillus

B9J2F2, Q6HC29,

thuringiensis, Bacillus cereus, Bacillus

B7HTW3, Q81611,

cereus, Bacillus anthracis, Bacillus

C3LB87, C3PCK3,

anthracis, Bacillus anthracis, Bacillus

Q81K97, A0RK73,

thuringiensis, Bacillus cereus, Bacillus

Q63215, A7GU88,

cytotoxicus, Bacillus subtilis,

P39845, P44446

Haemophilus influenzae

926
IlYTSGTTGRPKGV

Bacillus subtilis

P27206
Q4G176

927
IKAISFVGS

Bacillus subtilis, Bacillus subtilis,

A7BJC4, P42412,
O02252

Bacillus licheniformis

Q65D00

928
IKEGDIVKRTG

Clostridium perfringens, Clostridium

Q0S0Z3, Q8XID2,
P25705

perfringens, Clostridium perfringens,

Q0TNC2, Q180W8

ptoclostridium difficile

929
IKKAYRKLA

Desulfitobacterium hafniense,

Q24SS4, B8FUN3,
Q8NHS0

Desulfitobacterium hafniense,

Q182E7, Q8NLY8,

ptoclostridium difficile,

Q82EX7

Corynebacterium glutamicum,

Streptomyces avermitilis

930
IKKAYRKMALKYH

Campylobacter lari, Campylobacter

B9KFK6, Q5HTK3,
O75953

PD

jejuni, Campylobacter jejuni,

A7H2C0, Q85213,

Campylobacter jejuni, Campylobacter

A8FMW6, A1WOP5,

jejuni, Campylobacter jejuni,

Q7VG06

Helicobacter hepaticus

931
IKKAYRRKA

Propionibacterium acnes

Q6A997
P25686

932
IKPGAIVID

Listeria innocua, Listeria

Q92BZ4, B8DFW8,
P11586

monocytogenes, Listeria

Q8Y7C5, A0A1G1

monocytogenes, Listeria welshimeri

933
IKPGSMGKP

Bacillus subtilis, Bacillus subtilis

COSPB0, P39062
Q53FZ2

934
IKVGIGPGS

Helicobacter pylori

P56088
Q9P2T1

935
IKWNFTKFL

Neisseria meningitidis, Neisseria

A1KV41, P0A0T4,
P36969

meningitidis, Neisseria meningitidis,

P0A0T5, P0C2T0

Neisseria meningitidis

936
IKWNFTKFLID

Bacillus halodurans

Q9Z9N7
P36969

937
ILCFYGPPGVGKT

Helicobacter pylori, Helicobacter

Q9ZJL3, P55995
P36776

S

pylori

938
ILFIDEIHR

Helicobacter acinonychis,

Q17WP7, B2USM3,
Q96S55

Helicobacter pylori, Helicobacter

Q9ZM57, B5ZAF5,

pylori, Helicobacter pylori,

B6JKW4, Q1CUB7,

Helicobacter pylori, Helicobacter

O25699

pylori, Helicobacter pylori

939
ILFSAHSLP

Geobacter metallireducens

Q39ZQ5
P22830

940
ILGHVQRGG

Streptomyces coelicolor

Q9L1L8
Q01813

941
ILGQDPYHG

ptoclostridium difficile, Ralstonia

Q182G9, Q8XVE4
P13051

solanacearum

942
ILGQDPYHGP

Streptococcus pyogenes,

B5XL20, Q48U05,
P13051

Streptococcus pyogenes,

A2RFO0, Q1JHA5,

Streptococcus pyogenes,

Q1JC76, Q1JM60,

Streptococcus pyogenes,

Q9A072, Q1J724,

Streptococcus pyogenes,

B9DSB9, B4U3D4,

Streptococcus pyogenes,

C0M7J9, Q8P1B6,

Streptococcus pyogenes,

P0DG75, P0DG74,

Streptococcus pyogenes,

C0ME57, Q5XCK3

Streptococcus uberis, Streptococcus

equi, Streptococcus equi,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus equi, Streptococcus

pyogenes

943
ILILDEATS

Lactobacillus plantarum, Bacillus

Q88XV2, Q81J16,
Q2M3G0

cereus, Bacillus cereus, Bacillus

Q73F67, Q6HPN0,

thuringiensis, Bacillus thuringiensis,

A0R8K8, Q81VQ2,

Bacillus anthracis, Bacillus cereus,

Q63H62, Q03182,

Streptococcus thermophilus,

Q5M243, Q5LXJ3,

Streptococcus thermophilus,

Q8DMX9, Q97N50,

Streptococcus thermophilus,

Q04HV7

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

944
ILITGGAGF

Escherichia coli

P27830
Q8NBZ7

945
ILVDYSKNL

Aeromonas salmonicida, Aeromonas

A4STE1, A0KEM2
P06744

hydrophila

946
ILVFDLGGGTFDV

Corynebacterium diphtheriae

Q6NEY9
P11021

SLL

947
ILVHGDAAF

Bacillus cereus, Bacillus cereus,

C1ELG5, B7HH19,
Q9ULD0

Bacillus cereus, Bacillus cereus,

B9IU58, B7I0H2,

Bacillus cereus, Bacillus cereus,

Q81GF2, B7JEU9,

Bacillus anthracis, Bacillus anthracis,

Q81TK1, C3LAU3,

Bacillus anthracis, Bacillus cereus,

C3P487, B7IM94,

Bacillus cereus, Bacillus thuringiensis,

Q63EB1, Q6HL58,

Bacillus cereus, Bacillus cytotoxicus,

Q73BN8, A7GMD4,

Bacillus weihenstephanensis

A9VJX9

948
ILYTSGTTG

Bacillus subtilis

O07610
Q9H6R3

949
IMIHQPSGGA

Bacillus halodurans

Q9K888
Q16740

950
IMITPICPHSL

Clostridium phytofermentans

A9KMB6
Q95544

951
IMVARGDLG

Corynebacterium efficiens,

Q8FP04, P43924
P30613

Haemophilus influenzae

952
IMVGPGTGIAPF

Bacillus subtilis

O08336
Q9UBK8

953
IMVGPGTGVAPF

Bacillus megaterium

P14779
P16435

954
INGFGRIGR

Bacillus subtilis, Citrobacter koseri,

Q34425, A8APE1,
O14556

Edwardsiella ictaluri, Enterobacter

C5BAU7, A4WE72,

sp., Escherichia coli, Escherichia coli,
Q1R7A6, B7MZM0,

Escherichia coli, Escherichia coli,

B7UHW9, B1LDD2,

Escherichia coli, Escherichia coli,

B6I761, B7N7H3,

Escherichia coli, Escherichia coli,

P0A9B6, Q0TDS9,

Escherichia coli, Escherichia coli,

B1IT76, P0A9B7,

Escherichia coli, Escherichia coli,

B5YQB9, A8A467,

Escherichia coli, Escherichia coli,

B1XEL0, C5A0J7,

Escherichia coli, Escherichia coli,

B7LYU4, P0A9B8,

Escherichia coli, Escherichia coli,

B7LFI3, A7ZR35,

Escherichia fergusonii, Escherichia

B7LPD5, B7NHY6,

coli, Escherichia coli, Escherichia coli,

A1AFB1, B7MMA9,

Helicobacter pylori, Helicobacter

Q9ZKT0, P55971,

pylori, Klebsiella pneumoniae,

P24164, A6TDT2,

Klebsiella pneumoniae, Klebsiella

B5XUB7, B4EUH7,

pneumoniae, Proteus mirabilis,

P27726, Q59800

Pseudomonas aeruginosa,

Streptomyces aureofaciens

955
INGFGRIGRL

Clostridium pasteurianum, Clostridium

Q59309, O52631,
O14556

acetobutylicum, Staphylococcus

P0A038, Q6GB58,

aureus, Staphylococcus aureus,

P0A037, Q5HHP5,

Staphylococcus aureus,

Q6GIL8, P99136,

Staphylococcus aureus,

P0A036, Q8CPY5,

Staphylococcus aureus,

Q5HQV4

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

956
INIIDTPGHVDFT

Lactobacillus fermentum,

B2GDX1, Q03PV4,
Q96RP9

Lactobacillus brevis, Lactobacillus

B2G8Y0, A5VLK8,

reuteri, Lactobacillus reuteri,

Q88XY8, Q1WVA0,

Lactobacillus plantarum, Lactobacillus

Q8R602, Q250N5,

salivarius, Fusobacterium nucleatum,

B8G1W3, Q6A6L5,

Desulfitobacterium hafniense,

Q18CF4, Q97EH4,

Desulfitobacterium hafniense,

A0PXU3, A3DIZ9,

Propionibacterium acnes,

B9DYA6, A5N4P4,

ptoclostridium difficile, Clostridium

Q8F585, C3PKP1,

acetobutylicum, Clostridium novyi,

B050I4, B2GIL1,

Clostridium thermocellum, Clostridium

C5CC67, Q82DQ1,

kluyveri, Clostridium kluyveri,

P40173, B1W417

Corynebacterium efficiens,

Corynebacterium aurimucosum,

Finegoldia magna, Kocuria rhizophila,

Micrococcus luteus, Streptomyces

avermitilis, Streptomyces coelicolor,

Streptomyces griseus

957
INIIDTPGHVDFTIE

Lactobacillus delbrueckii,

Q1GBM0, Q04C17,
Q96RP9

VER

Lactobacillus delbrueckii,

Q74L90, Q046C7,

Lactobacillus johnsonii, Lactobacillus

A8YXK3, Q5FM92,

gasseri, Lactobacillus helveticus,

Q4JT40, Q39Y09,

Lactobacillus acidophilus,

B5EFP7, B3E7T2,

Corynebacterium jeikeium, Geobacter

A5V605

metallireducens, Geobacter

bemidjiensis, Geobacter lovleyi,

Sphingomonas wittichii

958
INIIDTPGHVDFTIE

Desulfovibrio alaskensis

Q30Z38
Q96RP9

VERALR

959
INNAAGNFI

Bacillus subtilis

O34717
Q16698

960
INSAVFPGLQGGP

Methylobacterium sp.
B0UML5
P34896

961
IPDYRGPNG

Streptomyces coelicolor

Q8CJM9
Q9NRC8

962
IPHNGCRPRK

Methylobacterium extorquens,

A9W4R7, B1LWQ1,
P82912

Methylobacterium radiotolerans,

B7L0S7, B1Z770

Methylobacterium extorquens,

Methylobacterium populi

963
IPPPNVTGSLH

Acinetobacter baylyi, Escherichia coli,

Q6F8F0, Q8XCB3,
P26640

Escherichia coli, Escherichia coli,

Q8FAD1, P07118,

Haemophilus influenzae,

A5UEN9, P43834,

Haemophilus influenzae,

A5UBZ9, Q4QKA4,

Haemophilus influenzae,

Q7VN93, Q9HXH0,

Haemophilus influenzae,

Q48MF2, Q887M3,

Haemophilus ducreyi, Pseudomonas

Q4ZXI0, Q4KHT9,

aeruginosa, Pseudomonas

Q88P76, Q98LB1,

savastanoi, Pseudomonas syringae,

Q92037, A5V592

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas putida, Rhizobium loti,

Rhizobium meliloti, Sphingomonas

wittichii

964
IPPPNVTGSLHLG

Streptomyces coelicolor,

O06851, Q82CA3
P26640

HA

Streptomyces avermitilis

965
IPVIANGDI

Haemophilus influenzae

P44965
O95620

966
IQFKLADMA

Bacillus subtilis

O34421
P16219

967
IQNALGSDI

Bacillus cytotoxicus, Bacillus

A7GT99, A9VIP3,
Q9BXR0

weihenstephanensis, Bacillus cereus,

B7HE51, Q817W6,

Bacillus cereus, Bacillus cereus,

B7IIS9, Q634C7,

Bacillus cereus, Bacillus thuringiensis,

Q6HDA9, C1ESW1,

Bacillus cereus, Bacillus cereus,

B7HQH6, A0RJ24,

Bacillus thuringiensis, Bacillus cereus,

Q73064, B7JQ03,

Bacillus cereus, Bacillus anthracis,

Q81LH2, C3L6U6,

Bacillus anthracis, Bacillus anthracis,

C3P9A4, B9IYZ1,

Bacillus cereus, Bacillus halodurans

Q9KDI5

968
IQVYEETSG

Clostridium perfringens, Clostridium

Q8XJW5, Q0TPW7,
P38606

perfringens, Clostridium perfringens,

Q0SSI2, Q896K4,

Clostridium tetani, Clostridium

B2UWY4, B2TP91,

botulinum, Clostridium botulinum,

Q184E7, Q08636,

ptoclostridium difficile, Enterococcus

A8AUJ7, A3CK48,

hirae, Streptococcus gordonii,

Q1JNS8, Q1JDX0,

Streptococcus sanguinis,

B1ICC9, B5E552,

Streptococcus pyogenes,

B8ZK31, C10ES2,

Streptococcus pyogenes,

Q97QA8, A2RC97,

Streptococcus pneumoniae,

Q5XE50, Q1J8S5,

Streptococcus pneumoniae,

Q9A1Q3, Q1JIX5,

Streptococcus pneumoniae,

Q48VL3, P0DA06,

Streptococcus pneumoniae,

P0DA07, Q8P2U6,

Streptococcus pneumoniae,

B5XJH3

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

969
IRGHRRTYVGS

ptoclostridium difficile

Q180E4
Q86WA8

970
IRNFSIVAH

Lactobacillus brevis, Lactobacillus

Q03QU8, Q88VN0,
Q8N442

plantarum, Lactobacillus fermentum,

B2GBR9, B2G6W5,

Lactobacillus reuteri, Lactobacillus

A5VJE9, B0UFE0,

reuteri, Methylobacterium sp.,
B8IMT0, A5I644,

Methylobacterium nodulans,

A7FXL9, B1KZP1,

Clostridium botulinum, Clostridium

A7GH10, B1ILM7,

botulinum, Clostridium botulinum,

C1FVU4, C3L3H1,

Clostridium botulinum, Clostridium

Q0SRD8, Q8XIS6,

botulinum, Clostridium botulinum,

Q0TNS2, A5N6L8,

Clostridium botulinum, Clostridium

Q2KDL5, B5ZXQ5,

perfringens, Clostridium perfringens,

Q1MMQ8, B3PYC6,

Clostridium perfringens, Clostridium

Q92SU3, Q98DV1

kluyveri, Rhizobium etli, Rhizobium

leguminosarum, Rhizobium

leguminosarum, Rhizobium etli,

Rhizobium meliloti, Rhizobium loti

971
IRPRGGDFLY

Parabacteroides distasonis

A6L8P3
Q9NTM9

972
IRPRGGDFLYS

Bacteroides fragilis, Bacteroides

Q5L9Y1, Q64Q87,
Q9NTM9

fragilis, Bacteroides thetaiotaomicron

Q89ZG1

973
IRTVMITGD

Bacillus cereus, Listeria

Q73E41, Q8Y805
Q4VNC0

monocytogenes

974
IRTVMITGDN

Rhizobium loti

Q98GX6
Q4VNC1

975
IRTVMVTGD

Pseudomonas aeruginosa, Rhizobium

P57698, Q92XJ0
Q9H7F0

meliloti

976
IRTYNFPQNRVTD

Bacillus licheniformis, Bacillus subtilis,

Q65DV1, P45872,
Q9UGC7

HRI

Bacillus weihenstephanensis, Bacillus

A9VSC7, A7GV79,

cytotoxicus, Lactobacillus plantarum,

Q88UT2, Q812I4,

Bacillus cereus, Bacillus thuringiensis,

Q6HAV4, Q630R9,

Bacillus cereus, Bacillus cereus,

Q72XC2, B9IRW2,

Bacillus cereus, Bacillus anthracis

Q81JX1

977
ISGAHLNPA

Bacillus subtilis

P18156
P29972

978
ISGAHLNPAV

Pseudomonas aeruginosa

Q9HWZ3
P29972

979
ISGGHFNPAV

Escherichia coli, Escherichia coli,

P60845, P60844,
O94778

Escherichia coli

Q8X6K6

980
ISGGHFNPAVS

Rhizobium meliloti

Q92NM3
O94778

981
ISGGHFNPAVSL

Rhizobium meliloti

Q92ZW9
O94778

982
ISRQLWWGH

Lactobacillus sakei, Enterococcus

Q38XD1, Q82ZW6,
P26640

faecalis, Staphylococcus carnosus,

B9DND4, Q6GG42,

Staphylococcus aureus,

Q7A0P4, A8Z2I4,

Staphylococcus aureus,

Q6G8R2, Q99TJ8,

Staphylococcus aureus,

A6QHJ8, Q5HFA8,

Staphylococcus aureus,

Q2FG72, A5ITI8,

Staphylococcus aureus,

Q2FXR8, A6U2D1,

Staphylococcus aureus,

Q2YTA0, Q931Q1,

Staphylococcus aureus,

A7X383, Q4L703,

Staphylococcus aureus,

Q5HNN9, Q8CS83,

Staphylococcus aureus,

Q49Y96, Q3K2S4,

Staphylococcus aureus,

Q8E1B5, Q99YS1,

Staphylococcus aureus,

Q8P040, Q4S5A4,

Staphylococcus aureus,

Q5M5J8, P0DG65,

Staphylococcus aureus,

P0DG64, Q97S45,

Staphylococcus aureus,

Q5XAW8, Q8DOU7,

Staphylococcus haemolyticus,

Q5M111, Q8DSL1,

Staphylococcus epidermidis,

Q8E650

Staphylococcus epidermidis,

Staphylococcus saprophyticus,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus thermophilus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus thermophilus,

Streptococcus mutans, Streptococcus

agalactiae

983
ISRQLWWGHRIPA

Lactobacillus plantarum, Lactobacillus

Q88UX7, Q74JZ8,
P26640

johnsonii, Lactobacillus acidophilus

Q5FKW5

984
ITAQNHGYA

Clostridium acetobutylicum

Q97FT2
P31327

985
ITEIYEGTSE

Clostridium acetobutylicum

P52042
P16219

986
ITEIYEGTSEI

Clostridium propionicum

G3KIM8
P16219

987
ITGASSGIG

Listeria monocytogenes,

P25145, Q4L8Y1
P56937

Staphylococcus haemolyticus

988
ITGASSGIGL

Bacillus subtilis, Helicobacter pylori

O32291, O05730
P56937

989
ITGPNMGGKST

Ralstonia pickettii, Ralstonia

B2U9E4, Q8Y093
P43246

solanacearum

990
ITGPNMGGKSTY

Bacillus clausii, Edwardsiella ictaluri,

Q5WFY3, C5BGI4,
P43246

Haemophilus influenzae,

P44834, Q9HY08,

Pseudomonas aeruginosa,

A6V1G8, B7V8C8,

Pseudomonas aeruginosa,

Q02R92, A4VJN9,

Pseudomonas aeruginosa,

Q48F92, Q4ZWP5,

Pseudomonas aeruginosa,

Q4KHE3, Q3KH79,

Pseudomonas stutzeri, Pseudomonas

C3KCT2

savastanoi, Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas fluorescens

991
ITGPNMSGKSTY

Lactobacillus johnsonii, Lactobacillus

P61668, B2GB17,
Q15457

fermentum, Lactobacillus salivarius,

Q1WT15, B3W9W4,

Lactobacillus casei, Lactobacillus

Q035Z2, Q048Y4,

casei, Lactobacillus delbrueckii,

Q5FLX5, Q03R33,

Lactobacillus acidophilus,

A8YTH9, Q1G938,

Lactobacillus brevis, Lactobacillus

Q38YR4, Q92BV3,

helveticus, Lactobacillus delbrueckii,

A0AIK5, B8DFS4,

Lactobacillus sakei, Listeria innocua,

C1L2V9, Q8Y789,

Listeria welshimeri, Listeria

Q71ZR7, Q03EQ7,

monocytogenes, Listeria

B9DPB9, A8AZU4,

monocytogenes, Listeria

A4W4J7, C1CTY2,

monocytogenes, Listeria

Q1JEH0, Q8NZ24,

monocytogenes, Pediococcus

A2RGX2, Q5X9F3,

ntosaceus, Staphylococcus carnosus,

Q3JYM3, B5XJ75,

Streptococcus gordonii,

Q1JJH0, Q1J9C1,

Streptococcus suis, Streptococcus

Q8DWW1, Q8E2R3,

pneumoniae, Streptococcus

Q48QT6, A3CR17,

pyogenes, Streptococcus pyogenes,

Q1J489, P0DC61,

Streptococcus pyogenes,

P0DC60, Q99XL8,

Streptococcus pyogenes,

B5E385, Q8DRW8,

Streptococcus agalactiae,

B9DW73, Q03MY4,

Streptococcus pyogenes,

Q5M1Z0, COMGC5,

Streptococcus pyogenes,

Q5M6I1, C0MAS5

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus sanguinis,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus mutans, Streptococcus

uberis, Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus equi, Streptococcus

thermophilus, Streptococcus equi

992
ITKELIEIISGA

Methylobacterium sp.,
B0UE40, A9W2R2,
P36542

Methylobacterium extorquens,

B1ZEE8, B7KUA3,

Methylobacterium populi,

B8IN02, C3M952,

Methylobacterium extorquens,

Q98EV7, B5ZSN8,

Methylobacterium nodulans,

Q92LK7, B3PQ69,

Rhizobium sp., Rhizobium loti,
Q1MAZ1

Rhizobium leguminosarum,

Rhizobium meliloti, Rhizobium etli,

Rhizobium leguminosarum

993
ITPTPLGEGK

Aeromonas salmonicida, Aeromonas

A4SPE5, A0KIN9
P11586

hydrophila

994
ITPTPLGEGKSTTT

Desulfovibrio desulfuricans

B8J0C2
P11586

IGLVQ

995
ITPVPGGVG

Clostridium tetani, Geobacter

Q894G6, Q39Z32,
P13995

metallireducens, Geobacter

Q74GN1

sulfurreducens

996
ITPVPGGVGP

Lactobacillus gasseri, Lactobacillus

Q044I0, Q74IM0,
Q9H903

johnsonii, Staphylococcus

Q8CPP4, Q5HQA7,

epidermidis, Staphylococcus

Q4L572, Q6GAF0,

epidermidis, Staphylococcus

A8Z1K5, A6QF52,

haemolyticus, Staphylococcus

Q2FI15, Q8NX95,

aureus, Staphylococcus aureus,

Q5HH21, Q2FZJ6,

Staphylococcus aureus,

Q99V34, Q7A697,

Staphylococcus aureus,

A7X0V3, A5IRV0,

Staphylococcus aureus,

A6U0N1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

997
ITPVPGGVGPMT

Acinetobacter baylyi, Akkermansia

Q6F9E6, B2UM17,
P13995

muciniphila, Bacillus pumilus, Bacillus

A8FF15, Q65HI8,

licheniformis, Lactobacillus salivarius,

Q1WUJ3, C4ZBG7,

Eubacterium rectale, Bacteroides

Q5LAX0, Q64RB7,

fragilis, Bacteroides fragilis,

Q8A7B8, A7ZCH3,

Bacteroides thetaiotaomicron,

A0RQ49, A3DEE6,

Campylobacter concisus,

B8J466, Q72F91,

Campylobacter fetus, Clostridium

A1VGV4, B9M769,

thermocellum, Desulfovibrio

A5GAM5, Q39WH4,

desulfuricans, Desulfovibrio vulgaris,

Q74EU7, Q7VGF6,

Desulfovibrio vulgaris, Geobacter

A4XY05, A4XXZ2,

daltonii, Geobacter uraniireducens,

Q48HJ1, Q88LI7,

Geobacter metallireducens,

Q8XZ10, Q2JZV0,

Geobacter sulfurreducens,

Q2KCC6, Q92RY3,

Helicobacter hepaticus,

Q989A7, Q93E15,

Pseudomonas mendocina,

Q1MLB6, Q92T88,

Pseudomonas mendocina,

A5VAA8, Q49WI7,

Pseudomonas savastanoi,

B9D045, Q3K2M6,

Pseudomonas putida, Ralstonia

Q8E168, Q8E6M3,

solanacearum, Rhizobium etli,

B5XM84, Q1JAV4,

Rhizobium etli, Rhizobium meliloti,

Q5X1324, Q1JL04,

Rhizobium loti, Rhizobium

A2RDM9, P0DF89,

leguminosarum, Rhizobium

Q1JG29, Q1J5U5,

leguminosarum, Rhizobium meliloti,

P0DF88, Q48SM7,

Sphingomonas wittichii,

Q7CN13, Q99YX2,

Staphylococcus saprophyticus,

Q97RI9, A8AW32,

Staphylococcus carnosus,

C0M7V0, B4U1W4,

Streptococcus agalactiae,

B9DUU0, Q03LK0,

Streptococcus agalactiae,

P96050, Q5M0P7,

Streptococcus agalactiae,

Q04L84, Q8DQD3,

Streptococcus pyogenes,

Q5M583, C0MD36,

Streptococcus pyogenes,

Q8DVC1

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus gordonii,

Streptococcus equi, Streptococcus

equi, Streptococcus uberis,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus thermophilus,

Streptococcus equi, Streptococcus

mutans

998
ITPVPGGVGPMTV

Haemophilus influenzae,

Q4QMI7, A5UAS4,
P11586

AMLM

Haemophilus influenzae,

P44313, A5UHL4

Haemophilus influenzae,

Haemophilus influenzae

999
ITSCTNTSNPSVM

Corynebacterium diphtheriae

Q6NH63
P21399

1000
ITVGILLSY

Bacillus subtilis

COSPB2
O95528

1001
ITVSEEVALKQA

Streptococcus pyogenes

Q99YC0
Q9H0R6

1002
IVAGGDGTL

Staphylococcus carnosus

B9DMT6
Q53H12

1003
IVEDIIDTG

Streptococcus pyogenes,

Q5XEL6, Q7CNQ9,
P00492

Streptococcus pyogenes,

P0DD40, P0DD41

Streptococcus pyogenes,

Streptococcus pyogenes

1004
IVETEAYLG

Listeria innocua, Listeria

Q92D89, P58621,
P29372

monocytogenes, Listeria

B8DEK7, C1L1K0,

monocytogenes, Listeria

Q721N6, A0AH42,

monocytogenes, Listeria

Q4L8K2, Q5HLQ3,

monocytogenes, Listeria welshimeri,

Q8CRC1, B9DLR4,

Staphylococcus haemolyticus,

P65416, Q6G6X6,

Staphylococcus epidermidis,

A8Z534, Q5HDL2,

Staphylococcus epidermidis,

P65415, P65414,

Staphylococcus carnosus,

A6QJI5, Q2FVS1,

Staphylococcus aureus,

A5IVC5, Q2FEF3,

Staphylococcus aureus,

A7X5V7, A6U471,

Staphylococcus aureus,

Q2YYZ2, Q6GE90

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1005
IVKYSPDCII

Bacillus methylotrophicus

A7Z7J8
P07195

1006
IVLADADLD

Lactobacillus casei

A5YBJ3
P00352

1007
IVLMAQIGCFVP

Clostridium acetobutylicum

Q97119
P43246

1008
IVLVDDSIVRG

Staphylococcus epidermidis,

Q5HQA0, Q8CT30
Q06203

Staphylococcus epidermidis

1009
IVNAANSSL

Escherichia fergusonii

B7LT90
Q9BQ69

1010
IVNAANSSLLGGG

Streptomyces griseus

Q9KHE2
Q9BQ69

GVDG

1011
IVSNASCTTNC

Aeromonas hydrophila, Aeromonas

A0KGD2, A4SRF2
O14556

salmonicida

1012
IVSNASCTTNCLA

Citrobacter freundii, Escherichia

P24748, P24750,
O14556

PLAKVI

hermannii, Escherichia fergusonii,

P0C8Z1, P24751

Escherichia vulneris

1013
IVVATPGRL

Bacillus cereus

Q81DF9
Q9GZR7

1014
IVVTDGERILGLGD

Aeromonas hydrophila, Aeromonas

A0KHR8, A4SKE9,
P48163

salmonicida, Citrobacter koseri,

A8AGN6, C5BCM3,

Edwardsiella ictaluri, Enterobacter

A4WAJ3, B1IRX9,

sp., Escherichia coli, Escherichia coli,
A8A036, P26616,

Escherichia coli, Escherichia coli,

B1XE70, C4ZWP8,

Escherichia coli, Escherichia coli,

B1LFD8, Q8FHH1,

Escherichia coli, Escherichia

B7LQX1, B7N4P2,

fergusonii, Escherichia coli,

B7LZ73, B7MUR3,

Escherichia coli, Escherichia coli,

B7L7H9, A7ZLS1,

Escherichia coli, Escherichia coli,

Q1RBT9, Q0THU1,

Escherichia coli, Escherichia coli,

A1AB75, B7NHU3,

Escherichia coli, Escherichia coli,

B7MMW1, B7URL9,

Escherichia coli, Escherichia coli,

B5Z1T9, Q8XAS9,

Escherichia coli, Escherichia coli,

A6T9K7, B5XX25,

Klebsiella pneumoniae, Klebsiella

B4ESY2

pneumoniae, Proteus mirabilis

1015
IYAAGDICT

Bacillus halodurans, Bacillus cereus,

Q9K7F3, Q816D9,
Q8WU10

Bacillus cereus, Bacillus cereus,

Q632D6, Q72YF6,

Bacillus thuringiensis, Bacillus

Q6HBX6, A0RKB9,

thuringiensis, Bacillus anthracis,

Q81XS0, A9VMZ3

Bacillus weihenstephanensis

1016
IYARGAQDMK

Campylobacter jejuni, Campylobacter

A8FMA1, B9KD35,
Q03154

lari, Campylobacter jejuni,

Q5HU53, A1W038,

Campylobacter jejuni, Campylobacter

Q0P9K4, A7H2V9,

jejuni, Campylobacter jejuni,

A7GX37, A7I005

Campylobacter curvus,

Campylobacter hominis

1017
IYRIDHYLGKE

Pseudomonas aeruginosa

O68282
P11413

1018
KADIGIAMG

Staphylococcus haemolyticus

Q4L970
P50993

1019
KAEKNAVSHR

Ralstonia solanacearum

Q8XXF4
Q9BY32

1020
KAFAAGADIKEMQ

Rhizobium meliloti

Q52995
P30084

1021
KAGRNRWLG

Sphingomonas wittichii

A5V5Z9
Q5T653

1022
KASGLAAGKGV

Fusobacterium nucleatum

Q8REV7
P22102

1023
KATSNICTAQALL

Neisseria gonorrhoeae

B4RN40
P23378

1024
KATSNICTAQALLA

Neisseria gonorrhoeae, Neisseria

Q5F761, A1KV85,
P23378

N

meningitidis, Neisseria meningitidis,

A9M1P7, Q9JT86

Neisseria meningitidis

1025
KDDRTGTGT

Lactobacillus plantarum, Lactobacillus

Q88W05, A8YUW0,
P04818

helveticus, Corynebacterium

Q6NIF2, Q8NS38,

diphtheriae, Corynebacterium

A4QCI7, Q8FR47

glutamicum, Corynebacterium

glutamicum, Corynebacterium

efficiens

1026
KDGEAVWFG

Lactobacillus delbrueckii,

P94869, P94870,
Q13867

Lactobacillus helveticus, Lactobacillus

P94868

delbrueckii

1027
KDGPLDMRMD

Aeromonas hydrophila, Aeromonas

A0KPY0, A4SI48,
A6NJ78

salmonicida, Aggregatibacter

C6AKG2, C6BYH4,

aphrophilus, Desulfovibrio salexigens,

A5UCX6, Q4QLG6,

Haemophilus influenzae,

P45057, Q0I1E1,

Haemophilus influenzae,

A5UIQ3, B2FNN0,

Haemophilus influenzae,

B4SJW8

Haemophilus somnus, Haemophilus

influenzae, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

1028
KDVKWILGQDPY

Listeria monocytogenes, Listeria

Q720K2, Q8Y7P6,
P13051

HGP

monocytogenes, Listeria innocua

Q92CI1

1029
KDVKWILGQDPY

Clostridium perfringens, Clostridium

Q0TUH0, Q0SWB8,
P13051

HGPNQAHG

perfringens, Clostridium perfringens

Q8XNR7

1030
KDVKWILGQDPY

Haemophilus parasuis

B8F6C3
P13051

HGPNQAHGL

1031
KDYYEILGVSR

Edwardsiella ictaluri

C5B7L8
Q9NXW2

1032
KDYYKILGV

Propionibacterium acnes

Q6A662
Q99615

1033
KEEIFGPVL

Pseudomonas aeruginosa

Q9I702
P30038

1034
KEEIFGPVM

Stenotrophomonas maltophilia,

B2FQ90, B4SHW0
P05091

Stenotrophomonas maltophilia

1035
KEGLALINGTQ

Fusobacterium nucleatum

Q8RDU4
P42357

1036
KEIFLRELISN

Bacillus subtilis, Clostridium

P46208, C3KXP4,
P14625

botulinum, Clostridium botulinum,

A5I3130, A7FV42,

Clostridium botulinum, Clostridium

C1FPN9, B1IN79,

botulinum, Clostridium botulinum,

A7GEU9, B1KUN4

Clostridium botulinum, Clostridium

botulinurn

1037
KEIFLRELISNASD

Bacillus clausii, Bacillus

Q5WJE6, A7ZAI5,
P14625

A

methylotrophicus, Bacillus halodurans

Q9KE51

1038
KERKGDYLG

Clostridium kluyveri, Clostridium

A5N3K4, B8I598
P17812

cellulolyticum

1039
KERRGDYLG

Methylobacterium sp., Desulfovibrio
B0U802, Q72BL2,
Q9NRF8

vulgaris, Desulfovibrio vulgaris,

A1VDL2, B8DJR8,

Desulfovibrio vulgaris, Desulfovibrio

Q310T4, B1M5Q9,

alaskensis, Methylobacterium

B8IP92, B1Z9R0,

radiotolerans, Methylobacterium

B7KUU9, B3Q30M2,

nodulans, Methylobacterium populi,

Q92QA0, Q2K871,

Methylobacterium extorquens,

Q1MGC4, B5ZPZ7,

Rhizobium etli, Rhizobium meliloti,

B9DME0, Q4L808,

Rhizobium etli, Rhizobium

Q49Z73, Q8CNI2,

leguminosarum, Rhizobium

Q5HM95

leguminosarum, Staphylococcus

carnosus, Staphylococcus

haemolyticus, Staphylococcus

saprophyticus, Staphylococcus

epidermidis, Staphylococcus

epidermidis

1040
KEVILSGGA

Staphylococcus aureus,

Q8NUM0, Q6G664
Q8NE62

Staphylococcus aureus

1041
KEVTLLGQNVN

Pseudomonas stutzeri, Pseudomonas

A4VQY3, A4XYW1
Q965Z6

mendocina

1042
KEVTLLGQNVNS

Clostridium beijerinckii, Geobacter

A6LWI1, A5G670,
Q965Z6

uraniireducens, Geobacter

Q74644

sulfurreducens

1043
KFYQASTSE

Aggregatibacter

Q9JRN5
Q60547

actinomycetemcomitans

1044
KFYTEDGNWDLV

Staphylococcus warneri,

Q9KW19, Q2PUJ9,
P04040

GNNTP

Staphylococcus epidermidis,

Q8CPD0, Q5HPK8,

Staphylococcus epidermidis,

Q4L643

Staphylococcus epidermidis,

Staphylococcus haemolyticus

1045
KGAMLTHGN

Haemophilus influenzae

P46450
Q9UKU0

1046
KGILLYGPPG

Kocuria rhizophila

B2GIP2
P46459

1047
KGLYKKARAGE

Citrobacter koseri, Enterobacter sp.,
A8ANW4, A4WDV5,
Q43252

Escherichia fergusonii, Escherichia

B7LWK5, Q1R7U1,

coli, Escherichia coli, Escherichia coli,

Q8FEJ2, A1AEU4,

Escherichia coli, Escherichia coli,

B7MYQ5, B7NT94,

Escherichia coli, Escherichia coli,

B7UHG9, B7MKM4,

Escherichia coli, Escherichia coli,

B1LQ71, B7N6Y0,

Escherichia coli, Escherichia coli,

B616E0, P0A6J1,

Escherichia coli, Escherichia coli,

B1XCS6, A8A3M9,

Escherichia coli, Escherichia coli,

C4ZZQ4, B7LXG2,

Escherichia coli, Escherichia coli,

B5Z3B2, P0A6J2,

Escherichia coli, Escherichia coli,

B7LEG8, A7ZQJ4,

Escherichia coli, Escherichia coli,

Q0TEA8, B1IU59,

Klebsiella pneumoniae, Klebsiella

A6TD42, B5XV31

pneumoniae

1048
KGLYKKARAGEI

Aeromonas hydrophila, Aeromonas

A0KP33, A4SRG6
O43252

salmonicida

1049
KGRTPNPDI

Finegoldia magna

B0S3R4
O75648

1050
KGSLLWVLD

Clostridium cellulolyticum, Clostridium

B812Q5, Q895H2
P20585

tetani

1051
KIDPYINID

Helicobacter pylori, Helicobacter

Q9ZM99, O25116,
P17812

pylori, Helicobacter pylori

Q1CUG1

1052
KIFITHLHGDH

Bacillus methylotrophicus, Bacillus

A7Z6F0, Q65HN6,
Q9H777

licheniformis, Lactobacillus plantarum,

Q88VG6, B2GBD1,

Lactobacillus fermentum, Bacillus

B9IXD7, Q731F6,

cereus, Bacillus cereus, Bacillus

B7HNQ7, Q635E2,

cereus, Bacillus cereus, Bacillus

Q6HE20, A0RID9,

thuringiensis, Bacillus thuringiensis,

C1ER14, B7JLZ5,

Bacillus cereus, Bacillus cereus,

Q81M88, C3LJR8,

Bacillus anthracis, Bacillus anthracis,

C3P7S4, Q03QP5,

Bacillus anthracis, Lactobacillus

B7HB12, B7IWQ5,

brevis, Bacillus cereus, Bacillus

Q818V3, A9VG79,

cereus, Bacillus cereus, Bacillus

B2G6S0, A5VJA0,

weihenstephanensis, Lactobacillus

A7GSG2, Q03W55,

reuteri, Lactobacillus reuteri, Bacillus

B8DBV5, Q03F36,

cytotoxicus, Leuconostoc

B4EUI8, A3CNR9,

mesenteroides, Listeria

Q8DT90, B9DUP5,

monocytogenes, Pediococcus

C0MAM9, A8AWX4,

ntosaceus, Proteus mirabilis,

C0MDJ9, B4U3M1,

Streptococcus sanguinis,

B5XL36, Q48TY8,

Streptococcus mutans, Streptococcus

Q8P1A6, A2REY2,

uberis, Streptococcus equi,

Q1JH87, Q1J705,

Streptococcus gordonii,

Q5XCH7, P0DF23,

Streptococcus equi, Streptococcus

Q1JM42, P0DF22,

equi, Streptococcus pyogenes,

Q1JC59, P60199

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

1053
KIGHGGTLD

Streptococcus pneumoniae,

Q97QJ3, Q8CWR2,
Q8WWH5

Streptococcus pneumoniae,

Q04KA7, A8AX28,

Streptococcus pneumoniae,

P0DD49, P0DD48,

Streptococcus gordonii,

Q3K189, P65856,

Streptococcus pyogenes,

P65857, A2RE90,

Streptococcus pyogenes,

Q1JLG7, Q1J6C1,

Streptococcus agalactiae,

P65858, Q5XBX7,

Streptococcus agalactiae,

P65859, Q1JBI5,

Streptococcus agalactiae,

Q1JGK3, Q48TB3,

Streptococcus pyogenes,

Q5LZV2, Q5M4G2

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus thermophilus,

Streptococcus thermophilus

1054
KIIRKEIPA

Haemophilus influenzae

P44956
P49773

1055
KILILDEAT

Lactobacillus brevis

Q03PY5
O15440

1056
KILNLRVFED

Bifidobacterium longum,

B3DQN7, B7G087,
Q8TEA8

Bifidobacterium longum,

Q8G4Q2

Bifidobacterium longum

1057
KIRLTGGEP

Haemophilus influenzae,

P45311, Q4QJR9,
Q9NZB8

Haemophilus influenzae,

A5UFB4, A5UBK4,

Haemophilus influenzae,

B2FUM0, B45L67

Haemophilus influenzae,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1058
KIRLTGGEPL

Bacillus cytotoxicus, Bacillus

A7GU01, Q65DY5,
Q9NZB8

licheniformis, Bacillus

A7Z9P0, P39757,

methylotrophicus, Bacillus subtilis,

A7GWA5, A0RMJ2,

Campylobacter curvus,

Q4ZU05, Q48HV8,

Campylobacter fetus, Pseudomonas

Q882V6, B1JCVV0,

syringae, Pseudomonas savastanoi,

Q88E69, A5VZZ2,

Pseudomonas syringae,

Q1I6J5, B0KST1,

Pseudomonas putida, Pseudomonas

Q8Y0K4, B3PQ08,

putida, Pseudomonas putida,

Q2K7L4, B5ZRM8

Pseudomonas entomophila,

Pseudomonas putida, Ralstonia

solanacearum, Rhizobium etli,

Rhizobium etli, Rhizobium

leguminosarum

1059
KIRLTGGEPLIRP

Pseudomonas fluorescens

Q3KA58
Q9NZB8

1060
KKLDVLSND

Acinetobacter baylyi

Q6F982
P09467

1061
KKRVFSGIQPTG

Helicobacter pylori, Helicobacter

P56396, Q9ZJX4
Q9UGM6

pylori

1062
KKVSLELGG

Escherichia coli, Pseudomonas

P25526, Q88RC0,
Q3SY69

putida, Pseudomonas aeruginosa

Q9I6M5

1063
KKVSLELGGKSP

Staphylococcus saprophyticus,

Q49Z69, Q5HMA0,
Q3SY69

Staphylococcus epidermidis,

Q8CNI5, Q4L803,

Staphylococcus epidermidis,

Q8NVG4, Q6G7I8,

Staphylococcus haemolyticus,

Q2FWD6, Q7A4D8,

Staphylococcus aureus,

Q99SD6, Q5HE78,

Staphylococcus aureus,

Q2FF06, Q6GEV3,

Staphylococcus aureus,

Q2YUN1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1064
KKWCDDYFF

Citrobacter koseri

A8ADF0
P36551

1065
KLAAFMKKF

Bacillus subtilis

P80862
Q9Y617

1066
KLAKQYHPD

Clostridium phytofermentans

A9KKT9
Q9NX36

1067
KLAMKYHPD

Rhizobium sp., Rhizobium meliloti
C3MC05, Q92T07
Q9UBS3

1068
KLFVDTDAD

Bacillus halodurans, Bacillus

Q9KDD8, A7GT59,
Q9BZX2

cytotoxicus, Bacillus cereus, Bacillus Cl

E555, Q6HDE5,

thuringiensis, Bacillus cereus, Bacillus

B7JP70, Q634G4,

cereus, Bacillus thuringiensis, Bacillus

A0RIZ3, B7IYN4,

cereus, Bacillus cereus, Bacillus

Q730F4, B9IYE5,

cereus, Bacillus cereus, Bacillus

B7HQD8, Q81LK8,

anthracis, Bacillus anthracis, Bacillus

C3L5Y6, C3P969,

anthracis, Bacillus cereus, Bacillus

B7HE15, Q817Z5

cereus

1069
KLHTGRSRNDQV

Acinetobacter baumannii,

B0VDE4, B7H1L9,
P04424

Acinetobacter baumannii,

B71338, A3M1E0,

Acinetobacter baumannii,

B0VMC7, B2I1W9,

Acinetobacter baumannii,

Q6FFB2, A4SIM6,

Acinetobacter baumannii,

A0KFV4, A8AKW2,

Acinetobacter baumannii,

A3DBU0, Q8XMJ8,

Acinetobacter baylyi, Aeromonas

Q0TTA6, B8I1A0,

salmonicida, Aeromonas hydrophila,

A7GGQ8, A0Q1Z1,

Citrobacter koseri, Clostridium

B1IK07, A9KQ51,

thermocellum, Clostridium

C3L1U2, C1FU67,

perfringens, Clostridium perfringens,

A5I5A3, A7FWU5,

Clostridium cellulolyticum, Clostridium

B1KXY0, B8DN65,

botulinum, Clostridium novyi,

A1VEQ1, Q72D36,

Clostridium botulinum, Clostridium

B8IZ53, C5BC57,

phytofermentans, Clostridium

A4WG51, B5Z062,

botulinum, Clostridium botulinum,

Q8X730, B6I5H6,

Clostridium botulinum, Clostridium

B7M714, B7LA60,

botulinum, Clostridium botulinum,

A7ZUH8, Q1R3V1,

Desulfovibrio vulgaris, Desulfovibrio

Q8FB96, Q0TAA0,

vulgaris, Desulfovibrio vulgaris,

A1AID8, B7MR51,

Desulfovibrio desulfuricans,

B7MI96, B7LUN5,

Edwardsiella ictaluri, Enterobacter

B7NFR0, P11447,

sp., Escherichia coli, Escherichia coli,
B1IVB8, A8A768,

Escherichia coli, Escherichia coli,

C5A0Q9, B1XBC5,

Escherichia coli, Escherichia coli,

B7NU40, B7UNT6,

Escherichia coli, Escherichia coli,

Q4QM89, Q0I2U1,

Escherichia coli, Escherichia coli,

P44314, A5UDR3,

Escherichia coli, Escherichia coli,

A5UHW3, B8F531,

Escherichia fergusonii, Escherichia

A6TGE4, B5XZ16,

coli, Escherichia coli, Escherichia coli,

B4F1G9, C3K426,

Escherichia coli, Escherichia coli,

A4VGX6, B7V5F3,

Escherichia coli, Escherichia coli,

Q02EA0, P50987,

Escherichia coli, Haemophilus

Q4K3X1, A6VE40,

influenzae, Haemophilus somnus,

A4XNY5, Q88694,

Haemophilus influenzae,

P59618, Q48QD3,

Haemophilus influenzae,

Q500N3, B1J1V0,

Haemophilus influenzae,

Q1I314, B0KH03,

Haemophilus parasuis, Klebsiella

Q3K4S8

pneumoniae, Klebsiella pneumoniae,

Proteus mirabilis, Pseudomonas

fluorescens, Pseudomonas stutzeri,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas aeruginosa,

Pseudomonas mendocina,

Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

savastanoi, Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas fluorescens

1070
KLSGGEKQRVAI

Rhizobium loti

Q98KI3
O75027

1071
KLTPNVTDI

Lactobacillus casei, Lactobacillus

Q038Z3, Q74J29
Q12882

johnsonii

1072
KLTPNVTDIV

Lactobacillus helveticus, Lactobacillus

A8YVZ9, Q5FJB5,
Q12882

acidophilus, Lactobacillus delbrueckii,

Q047M3, Q1G864,

Lactobacillus delbrueckii,

P77887

Lactobacillus plantarum

1073
KLYVRRVFITDD

Rhizobium loti

Q98JB6
P14625

1074
KMKETAEAYLG

Rhizobium loti

Q98DD1
P11021

1075
KMSKSLGNV

Bacillus halodurans

Q9K9V0
P26640

1076
KMSKSLGNVI

Lactobacillus johnsonii,

Q74JX6, Q846V6,
P26640

Staphylococcus epidermidis,

Q8CSX1, Q5HPZ9,

Staphylococcus epidermidis,

Q4L5P4, Q2YXH4,

Staphylococcus epidermidis,

Q6GHP2, P41972,

Staphylococcus haemolyticus,

A8Z3N1, P67509,

Staphylococcus aureus,

Q5HGN8, P67508,

Staphylococcus aureus,

A6QG93, A5IS79,

Staphylococcus aureus,

Q2FZ82, Q2FHP4,

Staphylococcus aureus,

A6U113, A7X1D8

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1077
KMSKSLGNVVDP

Rhizobium meliloti

Q92PX0
Q96GW9

1078
KMVHNGIEY

Bacillus subtilis

P12013
P52209

1079
KNRYVGRTFIQP

Bacillus subtilis

P00497
Q06203

1080
KNTYGTGCFLL

Fusobacterium nucleatum,

Q8RHZ9, Q0TMA0,
Q14409

Clostridium perfringens, Clostridium

Q8XHD3, Q0SQ01,

perfringens, Clostridium perfringens,

Q97JG4, A6M1Y8

Clostridium acetobutylicum,

Clostridium beijerinckii

1081
KPDILLLDEP

Bacillus subtilis

P37494
Q86UQ4

1082
KPHVNVGTIGHVD

Acinetobacter baylyi, Acinetobacter

Q6FF97, A3M1F6,
P49411

HG

baumannii, Acinetobacter baumannii,

B7H1K5, B2UQY9,

Akkermansia muciniphila,

Q250N4, B8G1W4,

Desulfitobacterium hafniense,

A4W5A0, P0A6N2,

Desulfitobacterium hafniense,

P0A6N3, Q1R5U4,

Enterobacter sp., Escherichia coli,
P0CE48, B1IVA7,

Escherichia coli, Escherichia coli,

Q0TA85, A1AlF3,

Escherichia coli, Escherichia coli,

A8A779, A7ZUJ2,

Escherichia coli, Escherichia coli,

Q1R5Y2, A1AGM6,

Escherichia coli, Escherichia coli,

P0CE47, B1IPW0,

Escherichia coli, Escherichia coli,

Q0TCC0, A8A5E6,

Escherichia coli, Escherichia coli,

A7ZSL4, Q7TTF9,

Escherichia coli, Escherichia coli,

Q0I1U9, P43926,

Escherichia coli, Haemophilus

A5UHC1, Q7VJ74,

ducreyi, Haemophilus somnus,

A6TEX7, Q5F5Q8,

Haemophilus influenzae,

P64027, A1KRF9,

Haemophilus influenzae, Helicobacter

P64026, P48864,

hepaticus, Klebsiella pneumoniae,

P09591, Q02T82,

Neisseria gonorrhoeae, Neisseria

A6UZH4, A4XZ92,

meningitidis, Neisseria meningitidis,

A4VHM8, A4VHL6,

Neisseria meningitidis, Neisseria

Q4K519, Q8XGZ0

gonorrhoeae, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

mendocina, Pseudomonas stutzeri,

Pseudomonas stutzeri, Pseudomonas

fluorescens, Ralstonia solanacearum

1083
KPNIVLIMVD

Clostridium perfringens, Clostridium

Q8XNV1, Q0TUK6
P54793

perfringens

1084
KPRYLMGVG

Lactobacillus plantarum, Desulfovibrio

Q88V05, Q30XF7,
Q9BXR0

alaskensis, Enterococcus faecalis

Q837E7

1085
KPVIAAVNGYAFG

Citrobacter koseri, Escherichia coli,

A8ALR7, P31551,
P30084

GG

Escherichia coli, Escherichia coli,

B1IRE0, Q8FLA6,

Escherichia coli, Escherichia coli,

Q0TLV3, B1LFW9,

Escherichia coli

Q8XA35

1086
KQFTTVVAD

Escherichia coli, Escherichia coli,

P0A868, P0A867,
P37837

Escherichia coli

P0A869

1087
KQRVAIARA

Lactobacillus sakei, Lactobacillus

Q38WL5, Q03P57,
O75027

brevis, Escherichia coli, Escherichia

P30750, Q1RFY9,

coli, Escherichia coli, Escherichia coli,

P63355, P63356,

Escherichia coli, Haemophilus

Q0TLD2, Q7VM95,

ducreyi, Haemophilus influenzae,

P44785, Q4QMH4,

Haemophilus influenzae,

Q0I5E9, Q7VI92,

Haemophilus somnus, Helicobacter

Q2FJI0, Q2GOV2,

hepaticus, Staphylococcus aureus,

Q5HIL5, Q93DA2

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus mutans

1088
KRIHEYKRQL

Escherichia coli

P0AC86
P06737

1089
KSGYGLDLE

Pseudomonas entomophila,

Q1I3R1, Q87UL9,
Q96NU7

Pseudomonas syringae,

Q48CD3, Q4ZLW0

Pseudomonas savastanoi,

Pseudomonas syringae

1090
KSGYGLDLETE

Ralstonia solanacearum

Q8XW31
Q96NU7

1091
KSLDFYTRVLG

Pseudomonas putida

P16635
Q04760

1092
KSNILLLGPTG

Clostridium acetobutylicum

Q97FT7
O76031

1093
KSNILLLGPTGSG

Clostridium tetani

Q891J8
O76031

KTLLAQT

1094
KSNILLLGPTGSG

Clostridium novyi, ptoclostridium

A0Q2L0, Q180E8,
O76031

KTLLAQTLA

difficile, Clostridium beijerinckii,

A6LT28, B9E684,

Clostridium kluyveri, Clostridium

A5N2K7, C6E2S9,

kluyveri, Geobacter sp., Geobacter
B5EI28, Q74C83,

bemidjiensis, Geobacter

Q39UH3, B9M0Y2,

sulfurreducens, Geobacter

A5GFA1, Q820F8,

metallireducens, Geobacter daltonii,

B1VXA8, Q9F316

Geobacter uraniireducens,

Streptomyces avermitilis,

Streptomyces griseus, Streptomyces

coelicolor

1095
KSNILLLGPTGSG

Clostridium botulinum, Clostridium

B1L1D6, A7GIH1,
O76031

KTLLAQTLAK

botulinum, Clostridium botulinum,

B1IND6, A5I6W0,

Clostridium botulinum, Clostridium

C1FLA5, C3KU76,

botulinum, Clostridium botulinum,

A7FYI1, Q0ST54,

Clostridium botulinum, Clostridium

Q0TQK3, Q8XKK2,

perfringens, Clostridium perfringens,

B2TPB8, B2UX12

Clostridium perfringens, Clostridium

botulinum, Clostridium botulinum

1096
KTFAYTNHT

Escherichia coli

P00490
P06737

1097
KTRLIGPNCPGVI

Bacillus subtilis

P80865
P53597

1098
KVEIAGPGF

Pseudomonas putida, Pseudomonas

B0KN43, Q88CU1,
P54136

putida, Pseudomonas putida,

A5WAC2, A4XPN9,

Pseudomonas mendocina,

A4VH02, Q87V03,

Pseudomonas stutzeri, Pseudomonas

Q4ZZF5, A6VDH2,

syringae, Pseudomonas syringae,

Q48PI2, Q9HUC8,

Pseudomonas aeruginosa,

Q02EW6, B7V3E4

Pseudomonas savastanoi,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa

1099
KVEIAGPGFIN

Citrobacter koseri, Edwardsiella

A8AFG5, C5B832,
P54136

ictaluri, Enterobacter sp., Escherichia
A4WBN1, B5YR22,

coli, Escherichia coli, Escherichia coli,

Q8XCH2, P11875,

Escherichia coli, Escherichia coli,

B1XHE4, C4ZQG0,

Escherichia coli, Escherichia coli,

B7L7S9, Q1RAQ8,

Escherichia coli, Escherichia coli,

Q0TGV6, A1AC37,

Escherichia coli, Escherichia coli,

B7MBT5, B7M2G7,

Escherichia coli, Escherichia coli,

B7USQ3, B6I0S7,

Escherichia coli, Escherichia coli,

B1J0L2, Q8FGQ0,

Escherichia coli, Escherichia coli,

B7MW70, B1LCZ5,

Escherichia coli, Escherichia coli,

B7NBM7, B7NS42,

Escherichia coli, Escherichia coli,

A8A178, A7ZN02,

Escherichia fergusonii, Klebsiella

B7LPH0, B5XPZ2,

pneumoniae, Klebsiella pneumoniae,

A6TB43, B4ETN5,

Proteus mirabilis, Stenotrophomonas

B2FJW0, B4STE2

maltophilia, Stenotrophomonas

maltophilia

1100
KVFYVWFDA

Streptomyces avermitilis

Q82F60
P56192

1101
KVIDATGKLV

Lactobacillus delbrueckii,

Q1G867, A8YVZ5,
Q9BPU6

Lactobacillus helveticus, Lactobacillus

Q047M6

delbrueckii

1102
KVLIANRGEIA

Pseudomonas aeruginosa

P37798
Q96RQ3

1103
KVVILGQDPYH

Lactobacillus delbrueckii,

Q1GB22, Q04BG7,
P13051

Lactobacillus delbrueckii,

Q74K70, A8YUE7,

Lactobacillus johnsonii, Lactobacillus

Q5FL46

helveticus, Lactobacillus acidophilus

1104
KVVILGQDPYHG

Arcobacter butzleri, Helicobacter

A8EWN8, Q7VGS1
P13051

hepaticus

1105
KVVILGQDPYHGP

Lactobacillus plantarum

Q88YG1
P13051

1106
KVVILGQDPYHGP

Bacillus cytotoxicus, Bacillus cereus,

A7GVE5, Q72X51,
P13051

NQAHGL

Bacillus halodurans, Bacillus cereus,

Q9K682, Q814M9,

Bacillus cereus, Bacillus cereus,

B7HG60, B7IRS8,

Bacillus cereus, Bacillus cereus,

Q630K2, B9IS32,

Bacillus cereus, Bacillus cereus,

B7HYF9, B7JHM3,

Bacillus weihenstephanensis, Bacillus

A9VSJ0, Q6HAN7,

thuringiensis, Bacillus thuringiensis,

A0RLI1, C1EQ68,

Bacillus cereus, Bacillus anthracis,

Q81JQ4, C3LFS7,

Bacillus anthracis, Bacillus anthracis,

C3P2F8, P67077,

Staphylococcus aureus,

A8YZS8, P67076,

Staphylococcus aureus,

Q5HI95, P67075,

Staphylococcus aureus,

A6QEN4, Q2G0J7,

Staphylococcus aureus,

A5IQD5, A6TZ58,

Staphylococcus aureus,

A7WZ22, Q2FJ62,

Staphylococcus aureus,

Q6GJ88, Q2Y583,

Staphylococcus aureus,

Q6GBQ6, Q8CQ65,

Staphylococcus aureus,

Q5HRG5

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1107
KYHPDKNPD

Rhizobium etli, Rhizobium

Q2KDW7, Q6RSN5,
Q8WW22

radiobacter, Rhizobium etli,

B3PXH2, Q1MN12

Rhizobium leguminosarum

1108
LAAGNTVVI

Staphylococcus epidermidis,

Q5HLA3, Q8CN24
O75891

Staphylococcus epidermidis

1109
LAAQSIGEP

Helicobacter hepaticus, Uncultured

Q7VJ82, B1GZ76
O95602

termite

1110
LACARIGAIHS

Escherichia coli

P77495
Q9H6R3

1111
LADDMGLGKT

Bacillus subtilis

P94593
Q2NKX8

1112
LADYLVVNVSSPN

Corynebacterium striatum,

Q9FB59, Q8FTC6,
Q02127

T

Corynebacterium efficiens,

Q8NQC0, A4QEA4

Corynebacterium glutamicum,

Corynebacterium glutamicum

1113
LASRDWSR

Helicobacter pylori, Helicobacter

Q9ZMP0, O06913
P31040

pylori

1114
LATKAREGKL

Bacillus subtilis

P21883
P10515

1115
LAYEPVWAIG

Rhizobium etli

Q2JZQ2
P60174

1116
LAYEPVWAIGTGK

Bacteroides thetaiotaomicron,

Q8A0U2, A6LFF0
P60174

TA

Parabacteroides distasonis

1117
LAYEPVWAIGTGK

Bacteroides vulgatus, Porphyromonas

A6KXL2, Q7MWI7,
P60174

TAT

gingivalis, Porphyromonas gingivalis

B2RII9

1118
LAYSGGLDT

Clostridium phytofermentans,

A9KHL4, C4Z4C1
P00966

Eubacterium eligens

1119
LAYSGGLDTS

Lactobacillus plantarum, Clostridium

P59603, A3DBU1,
P00966

thermocellum, Clostridium

Q0TTA5, Q8XMJ7,

perfringens, Clostridium perfringens,

B2TQ23, B2UYI0,

Clostridium botulinum, Clostridium

C5CAM5, Q8E7N1,

botulinum, Micrococcus luteus,

Q8E272, Q3K3Q4,

Streptococcus agalactiae,

A4VXZ4, A4W488,

Streptococcus agalactiae,

Q8CVVZ0, Q03IP8,

Streptococcus agalactiae,

Q5M2K2, Q5LXZ8,

Streptococcus suis, Streptococcus

Q04MW7, Q8DRI5,

suis, Streptococcus mutans,

B1I814, A3CQQ4,

Streptococcus thermophilus,

A8AUN6

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus sanguinis,

Streptococcus gordonii

1120
LDEADRMLDMGF

Escherichia coli

P21507
Q92841

1121
LDEATSALD

Campylobacter jejuni, Haemophilus

Q0P9C4, Q57180,
Q9NUT2

influenzae, Neisseria meningitidis,

Q9JXR3, Q9JW59,

Neisseria meningitidis, Neisseria

Q5F4X8, P0A2V1,

gonorrhoeae, Rhizobium radiobacter,

Q983H5, P18767,

Rhizobium loti, Rhizobium meliloti,

Q2K342, Q1MAB5

Rhizobium etli, Rhizobium

leguminosarum

1122
LDEPTAGLDP

Bacillus subtilis, Lactobacillus

P70970, Q1WSB9,
Q8WWZ4

salivarius, Lactobacillus sakei,

Q38UU0, Q18CI9,

ptoclostridium difficile, Clostridium

Q0TMS8, Q8XHV3,

perfringens, Clostridium perfringens,

Q890R3, Q97EK9,

Clostridium tetani, Clostridium

Q839D4, Q8CRI7,

acetobutylicum, Enterococcus

Q5HM28, Q8DRS0,

faecalis, Staphylococcus epidermidis,

Q48QM3, Q1JEC9,

Staphylococcus epidermidis,

Q1J450, A2RH10,

Streptococcus mutans, Streptococcus

Q1JJD0, Q7CMM8,

pyogenes, Streptococcus pyogenes,

Q1J983, Q5X9B6,

Streptococcus pyogenes,

Q99XI2, P0CZ27,

Streptococcus pyogenes,

P0CZ26, A3CRB8,

Streptococcus pyogenes,

Q8DMY0, Q04HV8,

Streptococcus pyogenes,

Q97N51, Q03I83,

Streptococcus pyogenes,

Q5M244, Q5LXJ4

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus sanguinis,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus thermophilus

1123
LDEPTNHLD

Bacillus subtilis, Bacillus subtilis,

O05519, O34512,
O9UG63

Bacillus subtilis

Q06476

1124
LDGDNVRHGLN

Bacillus licheniformis, Bacillus

Q65JT8, A8FD25,

pumilus, Clostridium kluyveri

A5N960
O95340

1125
LDGDNVRHGLNR

Rhizobium tropici, Rhizobium sp.,
P52978, O07309,
O095340

Rhizobium sp., Rhizobium meliloti

P72339, P13442

1126
LDGGMGTMIQ

Pseudomonas aeruginosa,

Q9I2Q2, O33465
Q99707

Pseudomonas putida

1127
LDIGTGTGL

Bacteroides fragilis, Bacteroides

Q5LCS1, Q64TX7,
Q9NVM4

fragilis, Bacteroides thetaiotaomicron

Q8A9H7

1128
LDIPLLFET

Rhizobium etli, Rhizobium loti

Q2KE98, Q98DY2
Q8WVC6

1129
LDIPLLFETK

Rhizobium meliloti

Q92TE9
Q8WVC6

1130
LDKLRHTHV

Lactobacillus casei, Lactobacillus

Q038M5, B3WER5
O60841

casei

1131
LDLCAAPGGK

Citrobacter koseri, Enterobacter sp.,
A8AQI3, A4WF97,
Q9H649

Escherichia coli, Escherichia coli,

Q1R644, A1AGI0,

Escherichia coli, Escherichia

B7MCQ4, B7LRQ5,

fergusonii, Escherichia coli,

B7N0S9, Q8FD12,

Escherichia coli, Escherichia coli,

B7NLK8, B5YT08,

Escherichia coli, Escherichia coli,

Q8XEE5, B6I202,

Escherichia coli, Escherichia coli,

B7M0Z4, B7LHZ0,

Escherichia coli, Escherichia coli,

B7UK12, A7ZSH7,

Escherichia coli, Escherichia coli,

B1LGP5, P36929,

Escherichia coli, Escherichia coli,

B1IQ11, A8A593,

Escherichia coli, Escherichia coli,

C4ZUE3, B1X6E1,

Escherichia coli, Escherichia coli,

B7NDR0, B5XNC2,

Klebsiella pneumoniae, Klebsiella

A6TEU2, B4F1L5

pneumoniae, Proteus mirabilis

1132
LDQLKQFTTVVAD

Ralstonia pickettii, Ralstonia

B2U9W5, Q8Y014
P37837

TGDF

solanacearum

1133
LDSARFRYF

Rhizobium loti

Q98EC4
Q6ZMR3

1134
LDSARFRYL

Staphylococcus epidermidis,

Q8CMZ0, Q5HL31
P00338

Staphylococcus epidermidis

1135
LDSRGNPTVE

Lactobacillus salivarius, Lactobacillus

Q1WSY0, B2GAM0
P13929

fermentum

1136
LDSRGNPTVEV

Lactobacillus sakei

Q38Y18
P13929

1137
LDTARFRFL

Bacillus caldotenax, Bacillus

P10655, Q59244
Q9BYZ2

caldolyticus

1138
LDTKGPEIRT

Bacillus licheniformis, Bacillus subtilis,

P51181, P80885,
P30613

Escherichia coli, Escherichia coli,

P0AD61, P0AD62,

Staphylococcus saprophyticus

Q49YC7

1139
LDTKGPEIRTG

Clostridium acetobutylicum

O08309
P30613

1140
LDVAGGTGDIAFR

Rhizobium etli, Rhizobium etli,

Q2KDB0, B3PZ92,
Q5HYK3

Rhizobium leguminosarum,

Q1MME0, B5ZYK8,

Rhizobium leguminosarum,

Q98GV1, Q925K7,

Rhizobium loti, Rhizobium meliloti,

C3MCY6

Rhizobium sp.

1141
LDVGCGSGIL

Clostridium phytofermentans

A9KKT8
Q86X55

1142
LDVGCGSGILS

Campylobacter lari, Campylobacter

B9KDE1, A7ZES6,
Q86X55

concisus, Campylobacter fetus,

A0RQL1, O07678,

Helicobacter pylori, Helicobacter

Q17WN8, B2USL4,

acinonychis, Helicobacter pylori,

Q1CUC6, Q9ZM65,

Helicobacter pylori, Helicobacter

Q7VHY7

pylori, Helicobacter hepaticus

1143
LDVLINNAGI

Bacillus subtilis, Bacillus subtilis,

Q8KWT4, P39640,
Q9HBH5

Bacillus amyloliquefaciens

Q8KW59

1144
LDVLVNNAG

Streptomyces violaceoruber

P16543
P16152

1145
LDVLVNNAGI

Staphylococcus aureus,

Q5HGK2, P0A0I0,
P16152

Staphylococcus aureus,

P0A0H9, Q6G9Y2,

Staphylococcus aureus,

Q6GHK4, P99093

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1146
LDYVDLYLLH

Pseudomonas putida

Q02198
P17516

1147
LEFVQFHPT

Ralstonia solanacearum

Q8XQG4
P31040

1148
LEGHLRSILG

Bacillus subtilis

O32076
Q14254

1149
LEINPLWT

Haemophilus parasuis, Rhizobium loti

B8F4Q2, Q98KT9
P53396

1150
LEINPLWTKD

Methylobacterium extorquens

P53594
P53396

1151
LELGGKSPLI

Pseudomonas putida, Pseudomonas

P0A391, P0A390
Q35Y69

sp.

1152
LELIASENF

Desulfovibrio vulgaris, Desulfovibrio

A1VEK5, Q72CT0,
P34896

vulgaris, Desulfovibrio alaskensis,

Q30YL7, B8DJF7,

Desulfovibrio vulgaris, Geobacter

B5E8U0, C6E348,

bemidjiensis, Geobacter sp.,
Q39V87, A5GF66,

Geobacter metallireducens,

B9M0W5, Q74CR5,

Geobacter uraniireducens, Geobacter

B3E1Z8

daltonii, Geobacter sulfurreducens,

Geobacter lovleyi

1153
LELLEGKILPGV

Geobacter lovleyi

B3E9Q7
P07205

1154
LELRVPFLD

Bacillus subtilis

P54420
P08243

1155
LEYRGYDSAG

Bacillus clausii, Lactobacillus

Q5WLG7, Q88YE7,
Q06210

plantarum, Campylobacter jejuni,

Q9PMT4, O26060,

Helicobacter pylori, Helicobacter

Q9ZJ94, P64228,

pylori, Staphylococcus aureus,

P64227, Q8NVE6,

Staphylococcus aureus,

Q6G7F8, Q5HE49,

Staphylococcus aureus,

Q6GE53

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1156
LFDEPTTGLD

Bacillus subtilis

P46903
Q9H222

1157
LFGTIDSWL

Lactobacillus acidophilus

Q5FHZ6
Q14409

1158
LFTLAESLGG

Escherichia coli

P00935
P32929

1159
LFVGSEGTLG

Bacillus subtilis

P94535
Q86WU2

1160
LGAGKTTLL

Escherichia coli, Pseudomonas

P24203, Q9HZQ2
Q5RIA9

aeruginosa

1161
LGAGKTTLLN

Pseudomonas chlororaphis

P31521
Q5RIA9

1162
LGAQWGDEGKGK

Haemophilus parasuis, Haemophilus

B8F8E6, A5UIZ2,
Q8N142

influenzae, Haemophilus influenzae,

Q4QL68, P45283,

Haemophilus influenzae,

A5UCM6, Q7VKR5,

Haemophilus influenzae,

Q82ER6, Q9X8P6,

Haemophilus ducreyi, Streptomyces

B1VMC3

avermitilis, Streptomyces coelicolor,

Streptomyces griseus

1163
LGDVYVNDAFGTA

Lactobacillus plantarum

Q88YH5
P07205

HR

1164
LGFPCNQFG

Staphylococcus epidermidis,

Q8C5R9, Q6GHD0,
P18283

Staphylococcus aureus,

P64291, Q6G9Q8,

Staphylococcus aureus,

P64290, P99097,

Staphylococcus aureus,

Q5HGC7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1165
LGGAKVADK

Propionibacterium acnes

Q6A9J3
P07205

1166
LGGRVKTLHP

Bacteroides thetaiotaomicron

Q8A155
P31939

1167
LGGTCVNVGCVP

Pseudomonas aeruginosa

P23189
P00390

KK

1168
LGGTCVNVGCVP

Haemophilus influenzae

P43783
P00390

KKVM

1169
LGGTCVNVGCVP

Escherichia coli

P06715
P00390

KKVMW

1170
LGHVQRGGTPSA

Streptomyces coelicolor

O08333
Q01813

FDR

1171
LGLPTGSTPL

Fusobacterium nucleatum,

Q8REG1, C5BGA6
P46926

Edwardsiella ictaluri

1172
LGMGADGHT

Aggregatibacter

P70715
O95479

actinomycetemcomitans

1173
LGNNKITDI

Listeria monocytogenes

P25147
Q9BXN1

1174
LGPNGAGKST

Streptomyces ucetius

P32010
Q8WWZ7

1175
LGPNGAGKTT

Bacillus subtilis, Bacillus subtilis

O07016, P42246
Q86UK0

1176
LGPNGAGKTTTI

Bacillus subtilis

P54592
Q86UK0

1177
LGPPGAGKGTQA

Geobacter sulfurreducens, Rhizobium

Q749A8, Q93FE6,
P54819

meliloti, Uncultured termite
B1GZA3

1178
LGPPGSGKGT

Stenotrophomonas maltophilia,

B4SI37, B2FT48
P27144

Stenotrophomonas maltophilia

1179
LGPTGSGKT

Eubacterium eligens, Clostridium

C4Z1T5, B8I8F6,
O76031

cellulolyticum, Corynebacterium

C3PI25, Q6NFU7,

aurimucosum, Corynebacterium

A4QGA7, Q8NN26,

diphtheriae, Corynebacterium

C4LJV6

glutamicum, Corynebacterium

glutamicum, Corynebacterium

kropnstedtii

1180
LGPTGSGKTLLA

Desulfitobacterium hafniense,

Q24SJ9, B8FV10
O76031

Desulfitobacterium hafniense

1181
LGPTGSGKTLLAQ

Clostridium thermocellum, Geobacter

A3DJ11, B3E1Z3
O76031

TLA

lovleyi

1182
LGRELGLPE

Rhizobium sp., Rhizobium meliloti
C3MCS5, Q92SQ3
P49915

1183
LGRKSGKGFY

Clostridium acetobutylicum

P52041
P40939

1184
LGSSQRFGVP

Pseudomonas fluorescens

Q4K416
P23378

1185
LGSVGEPIN

Methylobacterium radiotolerans,

B1M0M1, A9W5V0,
Q9NUB1

Methylobacterium extorquens,

B1ZB59, B7KPN8,

Methylobacterium populi,

Q88DW6, Q91558,

Methylobacterium extorquens,

Q98ET8

Pseudomonas putida, Pseudomonas

aeruginosa, Rhizobium loti

1186
LGTHDFSAF

Clostridium thermocellum

A3DJK8
Q8N0Z8

1187
LGVDKNASE

Lactobacillus johnsonii, Lactobacillus

Q74IT7, Q044A8,
Q99615

gasseri, Fusobacterium nucleatum

Q70WY6

1188
LGVPFNIASY

Leuconostoc mesenteroides

Q03YZ8
P04818

1189
LGVPFNIASYALL

Parabacteroides distasonis,

A6LIC2, Q5L9L6,
P04818

Bacteroides fragilis, Bacteroides

Q64PV5, A6L1Q8,

fragilis, Bacteroides vulgatus,

Q8A639

Bacteroides thetaiotaomicron

1190
LGVPFNIASYALLT

Lactobacillus casei, Lactobacillus

Q039F7, P00469,
P04818

casei, Staphylococcus epidermidis,

P0C0M5, P0A0M5,

Staphylococcus aureus,

Q5HMP6, P0C0M4

Staphylococcus epidermidis,

Staphylococcus epidermidis

1191
LGVSRDASD

Lactobacillus delbrueckii,

Q1G9R3, Q049W7
Q9H819

Lactobacillus delbrueckii

1192
LHDGPPYANG

Lactobacillus brevis, Lactobacillus

Q030I3, Q1WTA9,
Q9N5E4

salivarius, Lactobacillus reuteri,

B2G6L2, B2GB86,

Lactobacillus fermentum,

A7I157, B9KD44,

Campylobacter hominis,

P41257, Q5HU41,

Campylobacter lari, Campylobacter

C6BV89, Q30ZF7,

jejuni, Campylobacter jejuni,

Q747X9, Q4QLU5,

Desulfovibrio salexigens,

A5UIA3, P43824,

Desulfovibrio alaskensis, Geobacter

A5UDA6, Q7VP34,

sulfurreducens, Haemophilus

B6JNR5, P56456,

influenzae, Haemophilus influenzae,

Q1CRK7, Q9ZJJ1,

Haemophilus influenzae,

B2UVG2, B5Z943,

HaemophiluS influenzae,

Q17ZG3, A0AKC5,

Haemophilus ducreyi, Helicobacter

Q929Z6, Q8Y5N8,

pylori, Helicobacter pylori,

Q71Y01, C1KWW3,

Helicobacter pylori, Helicobacter

B8DBR2, Q03EY9,

pylori, Helicobacter pylori,

A5VY52, Q88Q92,

Helicobacter pylori, Helicobacter

B1JF83, B0KM84,

acinonychis, Listeria welshimeri,

B7V0A3, Q4ZYJ4,

Listeria innocua, Listeria

Q9HVM4, Q48NK6,

monocytogenes, Listeria

Q02GB7, A6VBU7,

monocytogenes, Listeria

Q1I4S5, C3KDX4,

monocytogenes, Listeria

Q889E4, P18330,

monocytogenes, Pediococcus

A4VI60, Q4K5U4,

ntosaceus, Pseudomonas putida,

Q3K6L5, A4XQV5,

Pseudomonas putida, Pseudomonas

Q983N4, Q8NX29,

putida, Pseudomonas putida,

Q6GA19, P0DG43,

Pseudomonas aeruginosa,

P0DG42, Q48SL8,

Pseudomonas syringae,

Q5XB14, Q8P068,

Pseudomonas aeruginosa,

Q99YW3, Q8DNW4,

Pseudomonas savastanoi,

Q04JB0, C1CSS4,

Pseudomonas aeruginosa,

B5E709, B1I721,

Pseudomonas aeruginosa,

Q8DVD3, C1CFN0,

Pseudomonas entomophila,

Q5M4X2, Q5M0Q5,

Pseudomonas fluorescens,

Q03L88, P0CB61,

Pseudomonas syringae,

B2IRR4, C1CLZ8,

Pseudomonas fluorescens,

C1C8P8, B8ZM55,

Pseudomonas stutzeri, Pseudomonas

Q8E177, Q3K2N4,

fluorescens, Pseudomonas

Q8E6N1, A3CLP4,

fluorescens, Pseudomonas

A8AW24

mendocina, Rhizobium loti,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus mutans, Streptococcus

pneumoniae, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus sanguinis,

Streptococcus gordonii

1193
LHDGPPYANGD

Bacillus subtilis, Bacillus clausii,

Q45477, Q5WFI3,
Q9NSE4

Ralstonia pickettii

B2UAQ4

1194
LHLGNYLGAI

Rhizobium loti, Rhizobium meliloti

Q98C31, Q92SI9
Q9UGM6

1195
LHRAFSVFLF

Streptomyces coelicolor,

Q9X7Q6, BlVTW2,
Q13907

Streptomyces griseus, Streptomyces

Q82MJ7

avermitilis

1196
LHTGRSRNDQV

Clostridium beijerinckii, Desulfovibrio

A6M1Z5, Q30Y139,
P04424

alaskensis, Eubacterium eligens,

C4Z0V2, B3E9X6,

Geobacter lovleyi, Geobacter daltonii,

B9M377, A5GDA7,

Geobacter uraniireducens, Geobacter

Q74GT9, Q39Z69,

sulfurreducens, Geobacter

C6E6Y9, B5ED16,

metallireducens, Geobacter sp.,
Q9JVG7, Q9K0G8,

Geobacter bemidjiensis, Neisseria

A9M2R4, A1KSP4,

meningitidis, Neisseria meningitidis,

Q5FA15, B2UA10,

Neisseria meningitidis, Neisseria

Q8XWV7, Q49W99

meningitidis, Neisseria gonorrhoeae,

Ralstonia pickettii, Ralstonia

solanacearum, Staphylococcus

saprophyticus

1197
LIANRGEIA

Bacillus subtilis

P49787
Q96RQ3

1198
LIASENFAS

Rhizobium loti

Q98A81
P34896

1199
LIGADPREI

Aeromonas hydrophila, Proteus

A0KJ32, B4EZU8
Q9Y697

mirabilis

1200
LIGQFGVGFYSAF

Methylobacterium populi,

B1Z9Y8, A9W1H7,
P14625

Methylobacterium extorquens,

B7KPG0

Methylobacterium extorquens

1201
LILDEATSALD

Acinetobacter baylyi, Bacillus subtilis,

Q6F9X0, P71082,
Q9NUT2

Escherichia coli, Escherichia coli,

Q1RDU4, Q8FJB1,

Escherichia coli, Escherichia coli,

Q0TJD9, P60752,

Escherichia coli, Ralstonia

P60753, Q8XXB6

solanacearum

1202
LILDEPTSG

Escherichia coli

P37624
Q9H221

1203
LISPFVGRILDW

Haemophilus parasuis

B8F5Q3
P37837

1204
LITGASSGIGL

Acinetobacter baylyi

Q6F7B8
P56937

1205
LIYTSGTTG

Bacillus subtilis

P39846
Q5FVE4

1206
LKGHRSVGG

Bacillus cereus, Bacillus cereus,

Q81BC0, Q638W1,
Q9Y617

Bacillus cereus, Bacillus thuringiensis,

Q734W9, Q6HGI0,

Bacillus anthracis, Bacillus circulans,

C3P210, Q59196,

Listeria monocytogenes, Listeria

Q8Y3L0, Q71VT6,

monocytogenes, Listeria innocua,

Q926T3, Q885T5,

Pseudomonas syringae,

A6V2Q8, C3K6J5,

Pseudomonas aeruginosa,

Q02PX3, B7V9J9,

Pseudomonas fluorescens,

Q9HZ66, A4XTE7,

Pseudomonas aeruginosa,

Q88M07, Q1IDA2,

Pseudomonas aeruginosa,

Q4ZQ94

Pseudomonas aeruginosa,

Pseudomonas mendocina,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas syringae

1207
LKGKQGRFR

Methylobacterium sp., Fusobacterium
B0UHX5, Q8RHI7,
O14802

nucleatum, Bifidobacterium

A1A316, Q8G515,

adolescentis, Bifidobacterium longum,

B3DTE1, Q8A470,

Bifidobacterium longum, Bacteroides

Q64NJ8, Q5L898,

thetaiotaomicron, Bacteroides fragilis,

A6KYK2, A6LE80,

Bacteroides fragilis, Bacteroides

B8DWJ5, Q0SQD7,

vulgatus, Parabacteroides distasonis,

P0C2E8, Q0TMN9,

Bifidobacterium animalis, Clostridium

A4QBG3, Q8NT25,

perfringens, Clostridium perfringens,

Q8FS96, B1VES2,

Clostridium perfringens,

Q6NJF6, C3PKN2,

Corynebacterium glutamicum,

C4LL70, Q4JT33,

Corynebacterium glutamicum,

B2GIK0, B1ZGS1,

Corynebacterium efficiens,

A9W8N9, B7KN46,

Corynebacterium urealyticum,

BlLY42, B8IS79,

Corynebacterium diphtheriae,

O33431, Q6A6K7,

Corynebacterium aurimucosum,

Q92QH6, Q1MIE8,

Corynebacterium kropnstedtii,

B3PW60, Q2K9M3,

Corynebacterium jeikeium, Kocuria

Q98N65, A5VBZ7,

rhizophila, Methylobacterium populi,

P0C0D9, B1W441,

Methylobacterium extorquens,

Q82DQ4, Q8CJT1

Methylobacterium extorquens,

Methylobacterium radiotolerans,

Methylobacterium nodulans,

Porphyromonas cangingivalis,

Propionibacterium acnes, Rhizobium

meliloti, Rhizobium leguminosarum,

Rhizobium etli, Rhizobium etli,

Rhizobium loti, Sphingomonas

wittichii, Streptococcus pyogenes,

Streptomyces griseus, Streptomyces

avermitilis, Streptomyces coelicolor

1208
LKGRDLLTL

Bacillus halodurans

Q9K8V8
P00480

1209
LKLIADVGLVG

Arcobacter butzleri

A8EV83
A4D1E9

1210
LKLIADVGLVGFP

Campylobacter fetus, Campylobacter

A0RR37, A7I166,
A4D1E9

N

hominis, Campylobacter jejuni,

Q0PC41, A7H029,

Campylobacter curvus,

A8FJQ1, Q5HX70,

Campylobacter jejuni, Campylobacter

A1VXH9

jejuni, Campylobacter jejuni

1211
LKNDTFLRA

Neisseria meningitidis, Neisseria

Q9K041, A1KT40,
P06132

meningitidis, Neisseria meningitidis,

Q9JV52, A9M3L2,

Neisseria meningitidis, Neisseria

B4RK59, Q5F9N1

gonorrhoeae, Neisseria gonorrhoeae

1212
LLAAGQSST

Pseudomonas aeruginosa, Ralstonia

Q9RPF3, Q8XSF6
P49279

solanacearum

1213
LLDEPTAGLDP

Listeria monocytogenes, Listeria

Q8Y7R4, Q720M2
O94911

monocytogenes

1214
LLDGFPRTL

Lactobacillus sakei, Enterococcus

Q38UT2, Q839E3
Q9UIJ7

faecalis

1215
LLDMKIFVDTD

Leuconostoc citreum

B1MXP1
Q9NWZ5

1216
LLDVAGGTGDIAF

Methylobacterium nodulans

B81J00
Q5HYK3

R

1217
LLGGGGVDG

Listeria monocytogenes, Listeria

Q8Y3S3, Q71W03,
Q9BQ69

monocytogenes, Listeria innocua

Q926Y8

1218
LLGHNGAGKST

Bacillus cereus

Q737I0
Q4W5N1

1219
LLGPNGAGK

Bacillus subtilis, Streptomyces

P94374, Q9RKC6,
Q8WWZ7

coelicolor, Streptomyces avermitilis

Q82HA2

1220
LLGPNGAGKST

Escherichia coli

P36879
Q8WWZ7

1221
LLGPNGAGKTTT

Haemophilus influenzae

P45073
Q86UK0

1222
LLGPNGAGKTTTI

Bacillus subtilis

O31427
Q86UK0

1223
LLGPPGAGKGTQ

Methylobacterium extorquens,

A9W4R9, B1LWQ5,
P54819

Methylobacterium radiotolerans,

B1Z772, B7L0S9

Methylobacterium populi,

Methylobacterium extorquens

1224
LLGPPGAGKGTQ

Acinetobacter baylyi, Acinetobacter

Q6FD71, B0VSA9,
P54819

A

baumannii, Acinetobacter baumannii,

A3M3G1, B0V9Q9,

Acinetobacter baumannii,

B2HVT0, B7GXT4,

Acinetobacter baumannii,

B7I8U4, Q97EJ9,

Acinetobacter baumannii,

Q18CH9, B1KSK4,

Acinetobacter baumannii, Clostridium

A5N4R8, B9DYD0,

acetobutylicum, ptoclostridium

C3KVN0, B1IGD3,

difficile, Clostridium botulinum,

A5I7I5, C1FMT0,

Clostridium kluyveri, Clostridium

A7FZ52, A7GJ53,

kluyveri, Clostridium botulinum,

A0PXW7, Q890Q5,

Clostridium botulinum, Clostridium

B0RZT0, B9M6F7,

botulinum, Clostridium botulinum,

A5GAW3, Q2K9J5,

Clostridium botulinum, Clostridium

B3PWU2, Q98N36,

botulinum, Clostridium novyi,

A5V5Y1

Clostridium tetani, Finegoldia magna,

Geobacter daltonii, Geobacter

uraniireducens, Rhizobium etli,

Rhizobium etli, Rhizobium loti,

Sphingomonas wittichii

1225
LLHGDLWSGN

Enterobacter aerogenes, Escherichia

P46381, P77739,
Q9H479

coli, Escherichia coli, Klebsiella

P58065, P46382

pneumoniae

1226
LLHGFPEFWY

Bacillus subtilis

O31581
Q8IUS5

1227
LLLDEPTNHLD

Bacillus subtilis, Escherichia coli,

P39115, P43672,
Q9UG63

Haemophilus influenzae, Rhizobium

Q57242, P12622,

radiobacter, Staphylococcus

P23212

epidermidis

1228
LLLDEPTNHLDL

Bacillus subtilis

O31716
Q9UG63

1229
LLLDEPTNHLDLD

Haemophilus influenzae

P44808
Q9UG63

A

1230
LLNYQTMVCD

Rhizobium meliloti, Rhizobium

Q92O11, B5ZQP8,
P23378

leguminosarum, Rhizobium etli,

Q2K813, B3PP20

Rhizobium etli

1231
LLYGPPGCGKTLI

Streptomyces griseus

B1W303
Q8NBU5

AKA

1232
LMAKDLGLAQ

Pseudomonas aeruginosa

Q9I5I6
P31937

1233
LMAQIGCFVP

Parabacteroides distasonis

A6LG92
P43246

1234
LMKDAIKPNL

Desulfitobacterium hafniense,

Q251P8, Q0TMI3,
P11586

Clostridium perfringens, Clostridium

A0PXN0, Q0SQ82,

novyi, Clostridium perfringens,

Q8XHL4, A6LPL1,

Clostridium perfringens, Clostridium

A7GJB8, B1IGY1,

beijerinckii, Clostridium botulinum,

A5I7P9, A7FZB0,

Clostridium botulinum, Clostridium

C3KVU4, C1FND0,

botulinum, Clostridium botulinum,

B2TI29, B2UXU5,

Clostridium botulinum, Clostridium

B1KTC6

botulinum, Clostridium botulinum,

Clostridium botulinum, Clostridium

botulinurn

1235
LMRLDKPIG

Pseudomonas mendocina

A4Y0P0
Q96H96

1236
LMRLDKPIGT

Haemophilus somnus, Pseudomonas

Q0I0W3, A4VGN3
Q96H96

stutzeri

1237
LNERHYGAL

Bacillus cereus

Q732Z5
P07738

1238
LNHASIIDG

Bacillus licheniformis, Bacillus subtilis,

Q65ML1, Q8KZM9,
O75600

Desulfovibrio desulfuricans,

B8J3V0, B5EEV8,

Geobacter bemidjiensis, Geobacter

B3EAE0

lovleyi

1239
LNLIDTPGHVDF

Fusobacterium nucleatum

Q8RFD1
Q8N442

1240
LNLRVFEDE

Clostridium perfringens, Clostridium

Q0SRP4, Q8XJ24,
Q8TEA8

perfringens, Clostridium perfringens

Q0TP24

1241
LNPARDLGPR

Streptococcus pneumoniae,

P0A3Q8, P0A3Q7
Q96P58

Streptococcus pneumoniae

1242
LNRKVLADLA

Desulfovibrio vulgaris, Desulfovibrio

B8DPM9, C6BRG8
Q9BYC9

salexigens

1243
LNRRKGPAV

Rhizobium meliloti, Rhizobium loti

Q92KW2, Q98DZ1
Q9Y2Z2

1244
LPAGTYCDV

Streptomyces thermoviolaceus,

P27350, P08486
P04746

Streptomyces hygroscopicus

1245
LPDLGPIGANGLA

Streptomyces coelicolor

Q952B5
O93099

N

1246
LPGTLPVLN

Clostridium acetobutylicum

Q97EX9
O75879

1247
LPGVGQNLQDHL

Proteus mirabilis, Pseudomonas

B4EX94, Q48CM7,
Q8NE62

E

savastanoi, Pseudomonas syringae,

Q4ZM63, Q88AE7,

Pseudomonas syringae,

A4XPI5

Pseudomonas mendocina

1248
LPHIGSATH

Citrobacter koseri, Enterobacter sp.,
A8ARD9, A4W577,
Q9UBQ7

Enterobacter agglomerans,

P58000, B7LTG7,

Escherichia fergusonii, Klebsiella

B5XMZ4, A6TFG7

pneumoniae, Klebsiella pneumoniae

1249
LPNSRIMIHQP

Campylobacter jejuni, Campylobacter

Q5HWX6, P54413,
Q16740

jejuni, Campylobacter jejuni,

A7H1R0, A8FJZ3,

Campylobacter jejuni, Campylobacter

A1VXS0, Q5F914,

jejuni, Neisseria gonorrhoeae,

Q9JU33, Q9JZ38,

Neisseria meningitidis, Neisseria

A1KUD9, A9LZN9

meningitidis, Neisseria meningitidis,

Neisseria meningitidis

1250
LPVFLLGHSMGG

Bacillus subtilis

O34705
Q99685

1251
LPVMVWIHGG

Bacillus subtilis

P37967
Q9UKY3

1252
LQRIYGISFP

Finegoldia magna

B0S169
A2RTX5

1253
LQTREQHIRR

Stenotrophomonas maltophilia,

B45567, B2FQE7
P23378

Stenotrophomonas maltophilia

1254
LQYRYLDLR

Leuconostoc mesenteroides

Q03WL7
Q6PI48

1255
LRGRGGAGFPTG

Rhizobium meliloti

P56913
P49821

1256
LRLQYRYLDLR

Lactobacillus salivarius

Q1WTU9
Q6PI48

1257
LRPETAQGIF

Bacillus cereus, Bacillus cereus,

Q632E8, Q72YG8,
P41250

Bacillus anthracis, Bacillus

Q81XT3, Q6HBZ1,

thuringiensis, Clostridium tetani,

Q899G6, B9DNL1,

Staphylococcus carnosus,

Q2YT14, P67035,

Staphylococcus aureus,

P67034, A8Z4A4,

Staphylococcus aureus,

Q6G902, Q6GGD5,

Staphylococcus aureus,

P99129, A6QHA8,

Staphylococcus aureus,

Q5HFJ5, A7X2W2,

Staphylococcus aureus,

Q2FY08, A5IT93,

Staphylococcus aureus,

Q2FGF8, A6U237,

Staphylococcus aureus,

Q5HNY2, Q8CSD5,

Staphylococcus aureus,

Q4L6R5, Q49Y08

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus,

Staphylococcus saprophyticus

1258
LRPHVVWFGE

Escherichia coli, Escherichia coli,

Q8FIM4, Q8X8E0,
Q9NXA8

Escherichia coli

P75960

1259
LRVFEDESG

Leuconostoc citreum

B1MZI4
Q8TEA8

1260
LRVVDASIMP

Acinetobacter baumannii,

B7I895, B7GYG5,
Q8NE62

Acinetobacter baumannii,

B0V945, B0VST3,

Acinetobacter baumannii,

B2HV79, Q6FDF9,

Acinetobacter baumannii,

B6I074, A7ZWV4,

Acinetobacter baumannii,

B7M2V5, B7L439,

Acinetobacter baylyi, Escherichia coli,

A7ZI50, P17444,

Escherichia coli, Escherichia coli,

B1J0W6, B1XE52,

Escherichia coli, Escherichia coli,

Q1RFM3, B7MCD0,

Escherichia coli, Escherichia coli,

B5Z1R0, Q8X6C6,

Escherichia coli, Escherichia coli,

B7N8L3, B7UJG4,

Escherichia coli, Escherichia coli,

Q0TKW1, Q8FKI9,

Escherichia coli, Escherichia coli,

B1LIJ7, A6T613,

Escherichia coli, Escherichia coli,

C3K3D3, A5WA97,

Escherichia coli, Escherichia coli,

Q3K5H3, Q4K4K7,

Klebsiella pneumoniae,

Q1IG70, Q88CVV6,

Pseudomonas fluorescens,

B0KN19, A6VEI3,

Pseudomonas putida, Pseudomonas

Q9HTJ2, B7V5R3,

fluorescens, Pseudomonas

Q02DZ0

fluorescens, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa

1261
LRYDLTVPFARY

Parabacteroides distasonis,

A6LIF7, Q5LAE0,
P12081

Bacteroides fragilis, Bacteroides

Q64OS2, Q8A6N7,

fragilis, Bacteroides thetaiotaomicron,

A6KXA6, Q7MTB3

Bacteroides vulgatus, Porphyromonas

gingivalis

1262
LSCQLYQRS

Acinetobacter baumannii,

B7H0P4, B7I4U0,
P04818

Acinetobacter baumannii,

Q6FER7, A0KG32,

Acinetobacter baylyi, Aeromonas

A4SIW7, P11044,

hydrophila, Aeromonas salmonicida,

A7Z5T3, P54081,

Bacillus subtilis, Bacillus

E0U0H8, A8FEB9,

methylotrophicus, Bacillus

Q9K7B5, Q5WDS1,

amyloliquefaciens, Bacillus subtilis,

Q1WU17, A5VJK9,

Bacillus pumilus, Bacillus halodurans,

Q03S95, Q4JX59,

Bacillus clausii, Lactobacillus

A6TDG3, C1KWH4,

salivarius, Lactobacillus reuteri,

Q8Y626, Q92AD4,

Lactobacillus brevis, Corynebacterium

B8DDM8, Q71YE1,

jeikeium, Klebsiella pneumoniae,

A0AJY0, Q8Y0U6,

Listeria monocytogenes, Listeria

Q92NQ5, Q98KH9,

monocytogenes, Listeria innocua,

Q1ME82, Q2K6G8,

Listeria monocytogenes, Listeria

Q49XN8, P67048,

monocytogenes, Listeria welshimeri,

Q6G9D4, P67046,

Ralstonia solanacearum, Rhizobium

A5ISV8, A7X2B3,

meliloti, Rhizobium loti, Rhizobium

P67047, A6U1P7,

leguminosarum, Rhizobium etli,

Q6GGY0, A8Z406,

Staphylococcus saprophyticus,

Q2YY40, Q5HFZ6,

Staphylococcus aureus,

Q2FYK5, A6QGX8,

Staphylococcus aureus,

Q2FH11, Q4L6D7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus

1263
LSCQLYQRSGD

Lactobacillus sakei,

Q38WX8, Q6A761
P04818

Propionibacterium acnes

1264
LSDELNHASIIDG

Bacillus cereus, Bacillus anthracis,

Q81I05, Q81V80,
Q75600

Staphylococcus aureus,

Q5HIC5, P60121,

Staphylococcus aureus,

Q8NXY3, Q6GBT7,

Staphylococcus aureus,

P60120, Q6GJB8

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1265
LSGCGVYDG

Escherichia coli

P0ABU5
P30042

1266
LSGGEKQRI

Escherichia coli

P77279
P33897

1267
LSGGQKQRI

Bacillus subtilis, Bacillus subtilis,

O07550, P54718,
Q9NRK6

Escherichia coli, Escherichia coli,

P77265, P22520,

Escherichia coli, Rhizobium sp.,
Q9EXN5, P55469,

Rhizobium meliloti

Q92LX3

1268
LSGGQKQRIAIAR

Bacillus subtilis

O31707
Q9NRK6

A

1269
LSGGQKQRL

Bacillus subtilis, Pediococcus

P45861, P36497,
Q9NUT2

acidilactici, Staphylococcus aureus,

Q2G2M9, Q6GFJ1,

Staphylococcus aureus,

Q5HEQ8, Q99T13,

Staphylococcus aureus,

Q2FFM9, Q7A0J1,

Staphylococcus aureus,

Q6G868, Q7A4T3,

Staphylococcus aureus,

Q2YU20

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1270
LSGGQKQRV

Bacillus clausii, Bacillus licheniformis,

Q5WCI1, Q65P77,
P33527

Clostridium tetani, Clostridium

Q895C4, Q8XK20,

perfringens, Corynebacterium

Q6NJ07, Q8Y454,

diphtheriae, Listeria monocytogenes,

Q71WH7, Q3K506,

Listeria monocytogenes,

Q4K441, Q87UI3,

Pseudomonas fluorescens,

Q49ZE0

Pseudomonas fluorescens,

Pseudomonas syringae,

Staphylococcus saprophyticus

1271
LSGGQKQRVA

Lactobacillus sakei, Lactobacillus

Q38UT9, Q1WSB8,
Q9NP78

salivarius, Lactobacillus delbrueckii,

Q1GBJ0, Q839D5,

Enterococcus faecalis,

Q8CQ57, Q5HRU5,

Staphylococcus epidermidis,

Q8CRI6, Q5HM27,

Staphylococcus epidermidis,

Q5HDY6, Q2FW34,

Staphylococcus epidermidis,

Q2FER7, Q8NVB5,

Staphylococcus epidermidis,

Q6G799, Q99S47,

Staphylococcus aureus,

Q7A470, Q6GEL3,

Staphylococcus aureus,

Q8NY21, Q6GC27,

Staphylococcus aureus,

Q6GJL2, Q2YYM4,

Staphylococcus aureus,

Q7A7E3, Q99WE1,

Staphylococcus aureus,

Q2YVT7, Q8DRR9,

Staphylococcus aureus,

Q8DWR3, Q3JYF4,

Staphylococcus aureus,

Q8E2L2, A3CRB9,

Staphylococcus aureus,

Q1J982, P0C0E9,

Staphylococcus aureus,

P0CZ29, Q1J449,

Staphylococcus aureus,

A2RH11, Q1JEC8,

Staphylococcus aureus,

Q7CMM7, P0CZ28,

Staphylococcus aureus,

Q5X9B5, Q48QM2,

Staphylococcus aureus,

Q1JJC9, P0C0E8

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus mutans, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus sanguinis,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

1272
LSGGQKQRVS

Enterococcus faecalis

Q832R5
P33527

1273
LSGGQRQRI

Acinetobacter baylyi, Bacillus

Q6F9A8, Q9K876,
O60706

halodurans, Pseudomonas

Q03024, Q88AS5,

aeruginosa, Pseudomonas syringae,

Q88CL2

Pseudomonas putida

1274
LSGGQRQRV

Bacillus subtilis, Escherichia coli,

P94360, Q8FKF5,
Q15438

Rhizobium etli, Rhizobium loti,

Q2K4V4, Q98G42,

Rhizobium meliloti, Rhizobium

Q9Z3R9, Q1MCN6,

leguminosarum, Rhizobium

Q1MFL8

leguminosarum

1275
LSGGVDSAVAA
Uncultured termite
B1GZY9
O75648

1276
LSGGVDSTV

Desulfovibrio maeticus

C4XSN8
P49915

1277
LSGHTHAGQIFP

Helicobacter pylori, Helicobacter

O25685, Q9ZM43
Q6ZT21

pylori

1278
LSGPSGAGKSTL

Helicobacter pylori, Helicobacter

P56103, Q1CUI1,
Q16774

pylori, Helicobacter pylori

Q9ZMB7

1279
LSIPVIANG

Haemophilus influenzae

P44606
Q9NX74

1280
LSMANAGPNTNG

Staphylococcus haemolyticus

Q4L4W9
A0A0B4J2A2

SQFF

1281
LSMANAGPNTNG

Staphylococcus epidermidis,

Q5HQK8, Q8CT84,
A0A0B4J2A2

SQFFI

Staphylococcus epidermidis,

Q5XAQ1

Streptococcus pyogenes

1282
LSMFPYPSG

Aeromonas salmonicida, Aeromonas

A4SJW8, A0KN87,
Q15031

hydrophila, Arcobacter butzleri,

A8ERV3, A7I0M0,

Campylobacter hominis,

B9KCS8, A7GZ81,

Campylobacter lari, Campylobacter

Q0I5C5, A5UDF4,

curvus, Haemophilus somnus,

Q4QLY8, P43827,

Haemophilus influenzae,

A5UI62, Q7VIY7

Haemophilus influenzae,

Haemophilus influenzae,

Haemophilus influenzae, Helicobacter

hepaticus

1283
LSMFPYPSGKLH

Acinetobacter baylyi, Acinetobacter

Q6F817, B0VKP9,
Q15031

MGHVR

baumannii, Acinetobacter baumannii,

B0V5H2, B2HTC4,

Acinetobacter baumannii,

B7I5I5, B7H051,

Acinetobacter baumannii,

A9M162, Q5FAJ3,

Acinetobacter baumannii, Neisseria

B4RNT1, Q9JW39,

meningitidis, Neisseria gonorrhoeae,

Q9JXT2, A1KS07,

Neisseria gonorrhoeae, Neisseria

Q4ZN90, Q1I4G7,

meningitidis, Neisseria meningitidis,

B0KJW8, Q88DN1,

Neisseria meningitidis, Pseudomonas

A5W9H9, B1J150,

syringae, Pseudomonas entomophila,

Q87VX3, Q4K5H6,

Pseudomonas putida, Pseudomonas

Q48DN1, C3K2L2,

putida, Pseudomonas putida,

A6V0C2, Q9HX33,

Pseudomonas putida, Pseudomonas

B7V9C9, Q025F5,

syringae, Pseudomonas fluorescens,

Q3K6B0, A4XYW8,

Pseudomonas savastanoi,

A4VQZ0

Pseudomonas fluorescens,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas mendocina,

Pseudomonas stutzeri

1284
LSPNGGGEP

Bacillus caldotenax, Bacillus subtilis

P28760, P54375
P04179

1285
LSQSGETAD

Streptococcus agalactiae,

Q8DZZ7, Q8E5P8,
Q06210

Streptococcus agalactiae,

Q8P057, P0DB32,

Streptococcus pyogenes,

P0DB33, Q99ZD3,

Streptococcus pyogenes,

Q8DTY0, Q5XBV6

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans, Streptococcus

pyogenes

1286
LSQSGETADTL

Clostridium perfringens, Clostridium

Q8XHZ7, Q97MN6,
Q06210

acetobutylicum, Escherichia coli,

Q8FBT4, P17169,

Escherichia coli, Escherichia coli,

Q8XEG2, P44708

Haemophilus influenzae

1287
LSVAVYNHYKR

Bifidobacterium longum,

Q8G5R1, Q8FN57
O76031

Corynebacterium efficiens

1288
LSVAVYNHYKRI

Propionibacterium acnes

Q6A7F1
O76031

1289
LTASAGIAPN

Stenotrophomonas maltophilia,

B4SIF5, B2FLR2
Q9UBT6

Stenotrophomonas maltophilia

1290
LTDYGFEGHP

Methylobacterium sp.,
B0ULK6, B1LUN5,
O75489

Methylobacterium radiotolerans,

B1ZA44, A9W1N1,

Methylobacterium populi,

Q98KQ7

Methylobacterium extorquens,

Rhizobium loti

1291
LTIRLALGG

Pseudomonas fluorescens,

C3K1H1, Q4KHQ8,
Q9Y3D3

Pseudomonas fluorescens,

Q3KHJ4, Q886V2,

Pseudomonas fluorescens,

Q4ZWY9, Q48LW0

Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas savastanoi

1292
LTPTRELAVQVK

Bacillus subtilis

P42305
Q9GZR7

1293
LTPVTLELGGKSP

Pseudomonas aeruginosa

Q9I6C8
P51648

1294
LTRLDHNRA

Kocuria rhizophila

B2GKC8
P40925

1295
LTRLDHNRAK

Propionibacterium acnes

Q6A6Z5
P40925

1296
LTTGTFLRG

Bacillus licheniformis, Rhizobium

Q65CN2, Q1MA19,
Q9Y2Z2

leguminosarum, Rhizobium etli

Q2K2S1

1297
LTYPLIGNYGI

Bacillus subtilis, Bacillus halodurans,

P25993, Q9K9V8,
P27708

Fusobacterium nucleatum

Q8RG87

1298
LVDDSIVRG

Pseudomonas aeruginosa,

Q51342, P99164,
Q06203

Staphylococcus aureus,

P65831, Q8NX91,

Staphylococcus aureus,

Q5HH14, Q6GAE3,

Staphylococcus aureus,

Q6GI14

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1299
LVDGKDVMP

Rhizobium leguminosarum,

Q1MM06, Q92SC4
P06744

Rhizobium meliloti

1300
LVDGKDVMPEVN

Haemophilus influenzae,

Q4QL07, A5UCG6,
P06744

Haemophilus influenzae,

A5UED2, P44312

Haemophilus influenzae,

Haemophilus influenzae

1301
LVEFMASGP

Streptomyces avermitilis

Q82CA0
O75414

1302
LVEVNCETDFV

Neisseria meningitidis, Neisseria

A1KWH7, A9M490,
P43897

meningitidis, Neisseria meningitidis,

P64051, P64050,

Neisseria meningitidis, Neisseria

Q5F5F4

gonorrhoeae

1303
LVEVNCETDFVS

Ralstonia pickettii

B2UB07
P43897

1304
LVGDVDFEGV

Methylobacterium extorquens

Q9X7F6
P13995

1305
LVGGASLKP

Clostridium phytofermentans

A9KPF8
P60174

1306
LVGGFGLCGIPE

Helicobacter pylori, Helicobacter

Q9ZLE3, P56006
P55809

pylori

1307
LVGGSTRIP

Enterococcus faecalis, Listeria

Q835R7, A0AIS4,
P48723

welshimeri, Listeria monocytogenes,

B8DE38, P0DJM2,

Listeria monocytogenes, Listeria

G2K046, Q71ZJ7,

monocytogenes, Listeria

C1KVC0, Q92BN8,

monocytogenes, Listeria

O06942, B2IMB5,

monocytogenes, Listeria innocua,

C1CQ18, C1CJ06,

Streptococcus mutans, Streptococcus

Q8CVVT3, B1IA52,

pneumoniae, Streptococcus

C1C5N7, Q04LY0,

pneumoniae, Streptococcus

Q03MR6, Q5M1T8,

pneumoniae, Streptococcus

C1CCQ8, P95829,

pneumoniae, Streptococcus

B8ZLY9, Q5M6D1,

pneumoniae, Streptococcus

C0ME86, C0M7T9

pneumoniae, Streptococcus

pneumoniae, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

thermophilus, Streptococcus equi,

Streptococcus equi

1308
LVIFPEGTR

Helicobacter pylori, Helicobacter

O25903, Q9ZJN8
Q9NUQ2

pylori

1309
LVLEVAQHLGE

Geobacter lovleyi, Geobacter

B3EA01, Q74GY0,
P06576

sulfurreducens, Geobacter daltonii,

B9LZ84, Q39Q56,

Geobacter metallireducens,

C6E9F1, B5EFI7,

Geobacter sp., Geobacter
A5G9D8

bemidjiensis, Geobacter

uraniireducens

1310
LVLTHFSQRY

Streptomyces avermitilis,

Q82BX8, Q9RDE4,
Q9H777

Streptomyces coelicolor,

B1VY42

Streptomyces griseus

1311
LVLTKPLGT

Geobacter sulfurreducens

Q74FK1
P49903

1312
LVLTPTRELA

Haemophilus influenzae

P44701
Q9GZR7

1313
LVLTPTRELAVQV

Bacillus cereus

Q81412
Q9GZR7

K

1314
LVNIFGGIV

Aeromonas salmonicida, Aeromonas

A4SND2, A0KJK9,
Q96I99

hydrophila, Edwardsiella ictaluri,

C5BEM7, A4W879,

Enterobacter sp., Escherichia coli,
B7M5P1, B6I7Z9,

Escherichia coli, Escherichia coli,

B7N9W6, B1LLG1,

Escherichia coli, Escherichia coli,

P0A837, P0A836,

Escherichia coli, Escherichia coli,

B1IY02, A7ZXY8,

Escherichia coli, Escherichia coli,

B1X6Q8, C4ZWK2,

Escherichia coli, Escherichia coli,

P0A838, B7NMS9,

Escherichia coli, Escherichia coli,

B5YQR7, B7LAD4,

Escherichia coli, Escherichia coli,

A7ZJA8, Q0I3A8,

Haemophilus somnus, Klebsiella

A6T6F6, B5XZD1,

pneumoniae, Klebsiella pneumoniae,

B4ESR1, A4XV90,

Proteus mirabilis, Pseudomonas

A4VKQ1

mendocina, Pseudomonas stutzeri

1315
LVPIGRGQREL

Lactobacillus salivarius, Lactobacillus

Q1WUC8, Q04BA5,
P25705

delbrueckii, Lactobacillus delbrueckii,

Q1GAW7, Q831A3,

Enterococcus faecalis, Enterococcus

P26679, P95787

hirae, Streptococcus mutans

1316
LVPIGRGQRELIIG

Helicobacter pylori, Helicobacter

P55987, B6JMX4,
P25705

D

pylori, Helicobacter pylori,

B5Z8D2, B2UUP2,

Helicobacter pylori, Helicobacter

Q17Y80, Q1CSD3,

acinonychis, Helicobacter pylori,

Q9ZK79

Helicobacter pylori

1317
LVPIGRGQRELIIG

Lactobacillus plantarum, Lactobacillus

Q88UU1, B2G689,
P25705

DR

reuteri, Lactobacillus reuteri,

A5VIQ9, Q38WK3,

Lactobacillus sakei, Lactobacillus

Q03A20, B3WDL6,

casei, Lactobacillus casei,

B2GAU3, Q042L3,

Lactobacillus fermentum,

Q74K17, A8YUJ9,

Lactobacillus gasseri, Lactobacillus

Q5FKY2, Q0Q0Y6,

johnsonii, Lactobacillus helveticus,

Q03V27, B1MW87,

Lactobacillus acidophilus,

Q03EL2

Lactobacillus brevis, Leuconostoc

mesenteroides, Leuconostoc citreum,

Pediococcus ntosaceus

1318
LVPIGRGQRELIIG

Arcobacter butzleri, Bacillus

A8EV72, A7GV58,
P25705

DRQTGKT

cytotoxicus, Bacillus cereus, Bacillus

C1F0N0, Q6HAX7,

thuringiensis, Bacillus cereus, Bacillus

B9IRT9, B7HY67,

cereus, Bacillus cereus, Bacillus

Q72XE6, Q630U1,

cereus, Bacillus cereus, Bacillus

B7JGN2, C3LFI1,

anthracis, Bacillus anthracis, Bacillus

Q81JZ3, A0RL97,

thuringiensis, Bacillus anthracis,

C3P1F6, Q814W0,

Bacillus cereus, Bacillus

A9VSA5, B7IQW0,

weihenstephanensis, Bacillus cereus,

B7HFK4, A7ZC35,

Bacillus cereus, Campylobacter

A0RR28, A7H019,

concisus, Campylobacter fetus,

A8FJR0, Q5HX61,

Campylobacter curvus,

Q9PJ21, A7I175,

Campylobacter jejuni, Campylobacter

A1VXI8, A7H1H9,

jejuni, Campylobacter jejuni,

B9KES1, Q7VJ23,

Campylobacter hominis,

Q8CNJ5, Q5HMB7,

Campylobacter jejuni, Campylobacter

Q4L7Y6, A5IUQ0,

jejuni, Campylobacter lar,

P63675, A7X4U5,

Helicobacter hepaticus,

P99111, P63676,

Staphylococcus epidermidis,

A8YY72, Q6G7K5,

Staphylococcus epidermidis,

Q6GEX0, Q2FF22,

Staphylococcus haemolyticus,

A6U3J0, Q2FWE8,

Staphylococcus aureus,

Q2YUJ9, Q5HE95,

Staphylococcus aureus,

A6QIU9, Q49Z52,

Staphylococcus aureus,

C1CLK8, B5E673,

Staphylococcus aureus,

C1CF95, B8ZLB1,

Staphylococcus aureus,

B2IQX2, C1C8A1,

Staphylococcus aureus,

Q7CRB1, Q97PT4,

Staphylococcus aureus,

C1CSD0, B1ICT1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

1319
LVPIGRGQRELIIG

Bacillus megaterium, Bacillus sp.,
P17674, P09219,
P25705

DRQTGKTS

Listeria monocytogenes, Listeria

Q71WP7, Q8Y4CO3

monocytogenes, Listeria innocua,

Q927W2, A0ALL5,

Listeria welshimeri, Streptococcus

Q5M106, Q03LX5,

thermophilus, Streptococcus

Q5M5J3, Q8E5V0,

thermophilus, Streptococcus

Q8E074, Q3K1J7,

thermophilus, Streptococcus

B9DRT4

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus uberis

1320
LVQLPLPEH

Pseudomonas mendocina

A4XTZ3
P13995

1321
LVQLPLPEHI

Haemophilus ducreyi

Q7VM86
P13995

1322
LVQLPLPEHID

Streptococcus sanguinis

A3CLQ4
P13995

1323
LVSGGTDNHLVLV

Campylobacter fetus

A0RQ16
P34897

1324
LVTGGAGFI

Escherichia coli, Escherichia coli,

P55293, P37759,
O95455

Escherichia coli, Neisseria

Q6E7F4, P55294,

meningitidis, Neisseria meningitidis,

Q9S642, P37761,

Neisseria gonorrhoeae, Rhizobium

P55462, Q9L9E8

sp., Streptomyces niveus

1325
LVTGGAGYIGSHT

Bacillus subtilis

P55180
Q14376

1326
LVTGGAGYIGSHT

Haemophilus influenzae

P24325
Q14376

V

1327
LVTGGAGYIGSHT

Bacillus halodurans

Q9KDV3
Q14376

VL

1328
LWIDSVAA

Desulfovibrio vulgaris, Desulfovibrio

A1VEQ5, P62214,
Q43542

vulgaris, Streptococcus uberis,

B9DW65, P49986

Streptococcus gordonii

1329
LWDAIVIGAG

Rhizobium meliloti

Q92XP4
Q9P0Z9

1330
LWEAQFGDF

Bacillus halodurans, Bacillus clausii

Q9KAT1, Q5WG56
Q96HY7

1331
LYAEQLSGS

Rhizobium leguminosarum,

QIM152, Q2K9E5,
Q93099

Rhizobium etli, Rhizobium

B5ZZA8, B3PWZ9,

leguminosarum, Rhizobium etli,

Q9X4F5, C3M930,

Rhizobium meliloti, Rhizobium sp.,
Q983J4

Rhizobium loti

1332
LYAEQLSGSAFT

Streptomyces avermitilis

Q828S5
Q93099

1333
LYDTYGFPV

Streptococcus pneumoniae,

B2IQK0, Q8DPC7,
P49588

Streptococcus pneumoniae,

Q04JW5, Q97Q48,

Streptococcus pneumoniae,

B1ICI3, Q8CVVY0,

Streptococcus pneumoniae,

A8AYI8, Q03LZ8,

Streptococcus pneumoniae,

Q99Z57, P0DG25,

Streptococcus mutans, Streptococcus

P0DG24, Q5M5L5,

gordonii, Streptococcus thermophilus,

Q5M126, Q1JG77,

Streptococcus pyogenes,

Q8E600, Q48SS4,

Streptococcus pyogenes,

Q1JL53, Q1JB08,

Streptococcus pyogenes,

Q5XBH1, Q1J5Z4,

Streptococcus thermophilus,

Q8E0C4, Q8P0E6,

Streptococcus thermophilus,

Q3K1P7, A2RDY3

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus pyogenes

1334
LYMTRIQKERF

Clostridium botulinum, Clostridium

B2TNG3, B2UW93
P27708

botulinurn

1335
LYVRRVFITD

Geobacter metallireducens

Q39SQ3
P14625

1336
LYWLSGLTC

Escherichia coli, Escherichia coli,

Q1R9R8, A1AD14,
P10768

Escherichia coli, Escherichia coli,

B1IY65, P33018,

Escherichia coli, Escherichia coli,

A8A215, B1X7P2,

Escherichia coli, Escherichia coli,

Q8FFU3, Q0TFT6,

Escherichia coli, Escherichia coli,

Q8X635, A7ZNX7,

Escherichia coli, Escherichia coli,

Q8FKG2, B1LKQ1,

Escherichia coli, Escherichia coli,

Q0TKS8, Q1RFI8,

Escherichia coli, Escherichia coli,

A1A834, A7ZIA3,

Escherichia coli, Escherichia coli,

A7ZX03, B1LIP0,

Escherichia coli, Escherichia coli,

Q8X5J5, B1J086,

Escherichia coli, Escherichia coli

B1XEU8, P51025

1337
MALPPCHAL

Bifidobacterium longum, Neisseria

Q8G3T9, A1KVB3,
P04818

meningitidis, Neisseria meningitidis,

Q9JY72, Q9JT57,

Neisseria meningitidis, Neisseria

Q5F732, B7V2Q5,

gonorrhoeae, Pseudomonas

Q02U73, Q9I6F1,

aeruginosa, Pseudomonas

A6UYE6, A4Y044,

aeruginosa, Pseudomonas

A4VGL9

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

mendocina, Pseudomonas stutzeri

1338
MAQIGCFVP

Bacillus cytotoxicus, Bacillus subtilis,

A7GR99, P49849,
P43246

Lactobacillus reuteri, Lactobacillus

B2G6E5, A5VIW9,

reuteri, Bacillus methylotrophicus,

A7Z4X5, Q04505,

Lactobacillus gasseri, Lactobacillus

Q88UZ7, Q82ZA2

plantarum, Enterococcus faecalis

1339
MASGPVVAMV

Streptomyces coelicolor

P50589
Q13232

1340
MEALNVLPP

Bacteroides vulgatus, Bacteroides

A6KZ38, Q64ZY1,
P49589

fragilis, Bacteroides fragilis

Q5LIT7

1341
MGCSNPHPH

Escherichia coli

P09148
P07902

1342
MGGQTALNC

Escherichia coli, Escherichia coli,

Q8FLB0, P63737,
P31327

Escherichia coli, Haemophilus

P00968, Q7VP67,

ducreyi, Neisseria meningitidis,

Q9JXW8, Q9JW02,

Neisseria meningitidis, Pseudomonas

P38100, Q87WP4,

aeruginosa, Pseudomonas syringae,

Q88DU6, Q8XZ83

Pseudomonas putida, Ralstonia

solanacearum

1343
MGHGDEIVL

Haemophilus parasuis

B8F6Y2
A2VDF0

1344
MGHGDEIVLAD

Haemophilus influenzae,

Q4QMI4, A5UAS6,
A2VDF0

Haemophilus influenzae,

P44778, A5UHL6

Haemophilus influenzae,

Haemophilus influenzae

1345
MGHVDHGKT

Desulfitobacterium hafniense,

Q24UI6, A1A0A2,
P46199

Bifidobacterium adolescentis,

Q8G3Y5, B3DQF0,

Bifidobacterium longum,

B7GNA3, C4Z5N7,

Bifidobacterium longum,

B8DW43, Q6A7M5,

Bifidobacterium longum, Eubacterium

A6L030, Q8A2A1,

eligens, Bifidobacterium animalis,

A6LHS1, Q64ZR4,

Propionibacterium acnes, Bacteroides

Q5LIN1, A7GG06,

vulgatus, Bacteroides

B1I149, C3L0B6,

thetaiotaomicron, Parabacteroides

A5I4J3, A7FVZ3,

distasonis, Bacteroides fragilis,

C1FS59, B1KWK7,

Bacteroides fragilis, Clostridium

A5N842, B2TJ55,

botulinum, Clostridium botulinum,

Q895J8, Q0SSD4,

Clostridium botulinum, Clostridium

Q8XJR8, Q0TPR7,

botulinum, Clostridium botulinum,

A0Q0Q7, B2V4G9,

Clostridium botulinum, Clostridium

A6LSQ4, Q97I51,

botulinum, Clostridium kluyveri,

B8I6E7, Q18BH4,

Clostridium botulinum, Clostridium

Q6NGN2, Q8FPA7,

tetani, Clostridium perfringens,

B2GKR5, A9M1D5,

Clostridium perfringens, Clostridium

A1KV51, Q9JYD2,

perfringens, Clostridium novyi,

Q9JTB5, B4RMZ3,

Clostridium botulinum, Clostridium

Q5F797, Q7MXE4,

beijerinckii, Clostridium

B2RHM9, A4XYE0,

acetobutylicum, Clostridium

A6VCK1, Q9HV55,

cellulolyticum, ptoclostridium difficile,

B7V1F6, Q02FS8,

Corynebacterium diphtheriae,

Q3KI84, Q4KIF6,

Corynebacterium efficiens, Kocuria

A4VPP0, C3K259,

rhizophila, Neisseria meningitidis,

Q1IF43, B0KHX8,

Neisseria meningitidis, Neisseria

A5W987, Q88DV7,

meningitidis, Neisseria meningitidis,

Q4ZNR2, Q87WQ5,

Neisseria gonorrhoeae, Neisseria

Q48E77, B1J2A9,

gonorrhoeae, Porphyromonas

B2UAA3, Q8XZV6,

gingivalis, Porphyromonas gingivalis,

B1VYN5, Q82K53,

Pseudomonas mendocina,

Q8CJQ8

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas stutzeri, Pseudomonas

fluorescens, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas savastanoi,

Pseudomonas putida, Ralstonia

pickettii, Ralstonia solanacearum,

Streptomyces griseus, Streptomyces

avermitilis, Streptomyces coelicolor

1346
MGHVDHGKTTLL

Lactobacillus reuteri, Lactobacillus

B2G6V6, A5VJE0
P46199

DK

reuteri

1347
MGKIDKKAL

Streptomyces carzinostaticus

Q84HC5
Q4G176

1348
MGPLGSPLS

Streptomyces coelicolor

Q93JL5
P35558

1349
MGVSGSGKS

Escherichia coli

P46859
Q5T6J7

1350
MIRPRGGDF

Streptococcus pyogenes

Q5XDL5
Q9NTM9

1351
MITASHNPK

Staphylococcus epidermidis,

Q5HLD2, Q8CN38
Q96G03

Staphylococcus epidermidis

1352
MITGDNPLT

Clostridium perfringens

Q0TRT3
Q9HD20

1353
MKSVGEVMA

Neisseria gonorrhoeae

Q59599
P31327

1354
MKSVGEVMAIGRT

Campylobacter jejuni, Rhizobium loti,

Q9PIL7, Q98I87,
P31327

F

Rhizobium meliloti

Q92PZ4

1355
MKVRGAPAI

Bacillus cereus, Bacillus cereus,

Q81IK7, Q63GN3,
Q9BV20

Bacillus anthracis, Bacillus

Q81ZC2, A0R946,

thuringiensis, Bacillus

A9VRK3, Q6HP54

weihenstephanensis, Bacillus

thu ring iensis

1356
MLACARIGA

Helicobacter pylori, Helicobacter

Q1CUA3, B6JKX8
Q9NUB1

pylori

1357
MLLLDEPTNHLD

Escherichia coli, Escherichia coli,

P0A9W3, P0A9W4,
Q9UG63

Haemophilus influenzae

P45127

1358
MLQQTQVATVI

Aeromonas hydrophila

P46230
Q9UIF7

1359
MLTGESIPV

Staphylococcus aureus,

Q2YWA3, Q8NUQ9,
Q4VNC0

Staphylococcus aureus,

Q6G6B7, Q7A3E6,

Staphylococcus aureus,

Q99R80, A6U4T8,

Staphylococcus aureus,

A5IVY3, A7X651,

Staphylococcus aureus,

A8Z3F8, A6QK47,

Staphylococcus aureus,

Q5HCZ3, Q2FDV0,

Staphylococcus aureus,

Q2FV64, Q6GDP1,

Staphylococcus aureus,

Q8CN02, Q5HL56

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1360
MPTGGGKSLCYQ

Escherichia coli

P15043
P54132

1361
MQEEIFGPV

Bacillus subtilis

P39634
P30838

1362
MQKEIFEQP

Haemophilus ducreyi

Q7VKK4
Q06210

1363
MRQAGRYLP

Geobacter daltonii, Geobacter

B9M7T4, A5GDW7,
P06132

uraniireducens, Geobacter sp.,
C6E7R9, B5E7R1

Geobacter bemidjiensis

1364
MRQAGRYLPE

Acinetobacter baylyi, Acinetobacter

Q6F9M1, A3M795,
P06132

baumannii, Acinetobacter baumannii,

B0VBT2, B7GZK6,

Acinetobacter baumannii,

B7I451, B2HVF8,

Acinetobacter baumannii,

B0VUQ9, A45J51,

Acinetobacter baumannii,

A8EVQ3, B9KFM9,

Acinetobacter baumannii, Aeromonas

A0RQV9, Q5HTL9,

salmonicida, Arcobacter butzleri,

A8FMU8, A1WOM7,

Campylobacter lari, Campylobacter

Q9PN54, A7H2D8,

fetus, Campylobacter jejuni,

A7ZEJ7, A7I2S8,

Campylobacter jejuni, Campylobacter

A7GZU8, A8AKS6,

jejuni, Campylobacter jejuni,

C5BHE8, A4W5C0,

Campylobacter jejuni, Campylobacter

B7N2J9, Q1R5W3,

concisus, Campylobacter hominis,

Q8FB74, A1AIG8,

Campylobacter curvus, Citrobacter

B7UPF2, B7MIY3,

koseri, Edwardsiella ictaluri,

B7NRT0, B6I5K8,

Enterobacter sp., Escherichia coli,
B1LNU9, B7NFT8,

Escherichia coli, Escherichia coli,

P29680, B1IUQ0,

Escherichia coli, Escherichia coli,

A8A797, C5A0T8,

Escherichia coli, Escherichia coli,

B1XC00, B7M7Q6,

Escherichia coli, Escherichia coli,

A7ZUL3, B5Z093,

Escherichia coli, Escherichia coli,

Q8X6X5, Q0TA68,

Escherichia coli, Escherichia coli,

B7LA91, B7LUK5,

Escherichia coli, Escherichia coli,

Q39Z08, Q746R5,

Escherichia coli, Escherichia coli,

B3EAR8, Q0I5E2,

Escherichia coli, Escherichia coli,

A6TGQ4, B5XYE1,

Escherichia coli, Escherichia coli,

B4EYT8, Q87V23,

Escherichia fergusonii, Geobacter

Q48PG2, Q4ZZD8,

metallireducens, Geobacter

B1J2J9, Q88CV6,

sulfurreducens, Geobacter lovleyi,

B0KN28, Q1IGA3,

Haemophilus somnus, Klebsiella

A5WAA7, Q3KJ97,

pneumoniae, Klebsiella pneumoniae,

Q4KJI4, C3KBH3,

Proteus mirabilis, Pseudomonas

B7V3C7, A6VDF5,

syringae, Pseudomonas savastanoi,

P95458, Q02EY3,

Pseudomonas syringae,

A4XPQ6, B2UGT5,

Pseudomonas putida, Pseudomonas

Q8XU90, Q1MA15,

putida, Pseudomonas putida,

C3MB70, Q98DY6,

Pseudomonas entomophila,

A5VA70

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

mendocina, Ralstonia pickettii,

Ralstonia solanacearum, Rhizobium

leguminosarum, Rhizobium sp.,

Rhizobium loti, Sphingomonas

wittichii

1365
MRVDFNVPMK

Fusobacterium nucleatum

Q8RFN7
P07205

1366
MTFGLACCA

Rhizobium etli

Q2K755
O75251

1367
MTFGLACCAVEM

Rhizobium loti, Sphingomonas

Q98KQ6, A5VAL8
O75251

wittichii

1368
MTFGLACCAVEM

Methylobacterium sp.,
B0ULK5, B8IUU7,
O75251

M

Methylobacterium nodulans,

B7K065, B1LUN6,

Methylobacterium extorquens,

A9Q1N2, B1ZA45,

Methylobacterium radiotolerans,

O68853, B5ZYL3,

Methylobacterium extorquens,

Q1MIL4, Q2K9T4,

Methylobacterium populi, Rhizobium

B3PVZ8

meliloti, Rhizobium leguminosarum,

Rhizobium leguminosarum,

Rhizobium etli, Rhizobium etli

1369
MTVEPGFGGQ

Streptomyces coelicolor

Q9L0Z5
Q96AT9

1370
MVYVRGHAED

Rhizobium etli, Rhizobium

Q2KB43, B5ZUG2,
Q8NE62

leguminosarum, Rhizobium

Q1MJU4, C3MIE4,

leguminosarum, Rhizobium sp.,
B3PTE0

Rhizobium etli

1371
MYCTGGIRCE

Citrobacter koseri, Enterobacter sp.,
A8A124, A4W968,
Q5T7W7

Escherichia fergusonii, Escherichia

B7LT80, B5YVS5,

coli, Escherichia coli, Escherichia coli,

Q8X8P2, Q8FIR7,

Escherichia coli, Escherichia coli,

Q0TJ18, B1IV47,

Escherichia coli, Escherichia coli,

A7ZZ13, P24188,

Escherichia coli, Escherichia coli,

B1X9G8, C4ZRZ5,

Escherichia coli, Escherichia coli,

B7M930, B7NL80,

Escherichia coli, Escherichia coli,

B7LFG6, A7ZKF9,

Escherichia coli, Escherichia coli,

B1LIV6, A1A9V1,

Escherichia coli, Escherichia coli,

B7MIJ6, B6I9D2,

Escherichia coli, Escherichia coli,

B7NAT1, B7MTI7,

Escherichia coli, Klebsiella

B7UP69, B5XXK0,

pneumoniae, Rhizobium

B5ZQU6, Q2K443,

leguminosarum, Rhizobium etli,

Q1MBM8, Q92LX6,

Rhizobium leguminosarum,

C3M8W9

Rhizobium meliloti, Rhizobium sp.

1372
MYGQMTAGS

Acinetobacter baumannii,

B2I2C4, B0V9X6,
Q96N76

Acinetobacter baumannii,

B7I271, B7GUU5,

Acinetobacter baumannii,

B0VPV2, Q9KBE5,

Acinetobacter baumannii,

A9VPT7, A7GQZ9,

Acinetobacter baumannii, Bacillus

B7J179, Q81Y46,

halodurans, Bacillus

C3L983, C3P4M1,

weihenstephanensis, Bacillus

Q637H9, C1EN92,

cytotoxicus, Bacillus cereus, Bacillus

A0RH38, B7ISJ1,

anthracis, Bacillus anthracis, Bacillus

B7HCC9, Q733H9,

anthracis, Bacillus cereus, Bacillus

Q6HFF0, B9IUG9,

cereus, Bacillus thuringiensis, Bacillus

B7HKJ0, Q81AC7,

cereus, Bacillus cereus, Bacillus

A7ZAE5, P25503,

cereus, Bacillus thuringiensis, Bacillus

A8AJ16, A4W8B4,

cereus, Bacillus cereus, Bacillus

A6T6L0, B5XZ80,

cereus, Bacillus methylotrophicus,

B8II06, C3K803,

Bacillus subtilis, Citrobacter koseri,

B1J2Q5, Q9HU83,

Enterobacter sp., Klebsiella
B7V3J3, Q02ER6,

pneumoniae, Klebsiella pneumoniae,

Q88CZ6, A5WA67,

Methylobacterium nodulans,

Q1I3Q8, B0KM58,

Pseudomonas fluorescens,

A6VDL7, Q87UM6,

Pseudomonas putida, Pseudomonas

Q4ZLW7, P25080,

aeruginosa, Pseudomonas

Q48CE0, Q9AGU4,

aeruginosa, Pseudomonas

Q8XW28, Q92V80,

aeruginosa, Pseudomonas putida,

Q983H8, A5VFA2,

Pseudomonas putida, Pseudomonas

P67418, Q6G6Y9,

entomophila, Pseudomonas putida,

Q5HDM6, P67417,

Pseudomonas aeruginosa,

Q6GEA4, Q931G1,

Pseudomonas syringae,

Q49ZQ7, B4SP57,

Pseudomonas syringae,

B2FKG1

Pseudomonas putida, Pseudomonas

savastanoi, Pseudomonas syringae,

Ralstonia solanacearum, Rhizobium

meliloti, Rhizobium loti,

Sphingomonas wittichii,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1373
MYTSGSTGRPKG

Bacillus subtilis

O31827
O60488

VM

1374
NANGVDLNRNFP

Escherichia coli, Escherichia coli

P0ACV6, P0ACV7
P15169

1375
NASGINDGAA

ptoclostridium difficile,

Q18AR0, Q5HIU0,
Q9BWD1

Staphylococcus aureus,

Q2YVF5, Q2FJQ9,

Staphylococcus aureus,

Q2G124, Q6GJW4,

Staphylococcus aureus,

Q8NY95, Q6GCB8,

Staphylococcus aureus,

Q99WM3, Q7A7L2

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1376
NASGINDGAAA

Haemophilus influenzae,

P44873, Q8CQN7,
Q9BWD1

Staphylococcus epidermidis,

Q5HS07

Staphylococcus epidermidis

1377
NASGINDGAAAV

Acinetobacter baylyi, Acinetobacter

Q43974, Q43935
Q9BWD1

baylyi

1378
NASRTMLFNIH

Lactobacillus salivarius, Lactobacillus

Q1WVJ0, Q88ZF1,
Q14409

plantarum, Clostridium tetani

Q891B8

1379
NASTRFSDG

Eubacterium rectale, Eubacterium

C4Z9V4, C4Z075,
P54886

eligens, Helicobacter hepaticus

Q7VI05

1380
NCETDFVSRN

Ralstonia solanacearum

Q8XZJ0
P43897

1381
NCNPETVSTD

Helicobacter pylori, Helicobacter

Q9ZKT2, O25577
P31327

pylori

1382
NDAFGTAHR

Lactobacillus fermentum

B2GAL8
P07205

1383
NDAFGTAHRAH

Leuconostoc mesenteroides,

Q03UX8, B1MW69
P07205

Leuconostoc citreum

1384
NDNLMELLIMI

Lactobacillus plantarum, Clostridium

Q88Z84, Q899I8,
P11908

tetani, Enterococcus faecalis

Q82ZA5

1385
NERLEFLGD

Clostridium botulinum, Clostridium

B2V4D6, B2TJ22,
Q9NRR4

botulinum, Clostridium beijerinckii,

A6LSM2, Q895M9,

Clostridium tetani, Clostridium

Q8XJN8, Q6NGH3,

perfringens, Corynebacterium

B8F3C7, Q7VL75,

diphtheriae, Haemophilus parasuis,

Q82JT9, Q9ZBQ7

Haemophilus ducreyi, Streptomyces

avermitilis, Streptomyces coelicolor

1386
NERLEFLGDA

Bacteroides thetaiotaomicron

Q8A2E8
Q9NRR4

1387
NERLEFLGDAV

Arcobacter butzleri, Bacillus

A8EV88, A7Z4L3,
Q9NRR4

methylotrophicus, Bacillus

Q65JQ5, P51833,

licheniformis, Bacillus subtilis, Bacillus

A9VT87, Q9KA05,

weihenstephanensis, Bacillus

Q819V8, B7IUK8,

halodurans, Bacillus cereus, Bacillus

B7HDX2, Q6HEW6,

cereus, Bacillus cereus, Bacillus

C1EP73, C3P5Q0,

thuringiensis, Bacillus cereus, Bacillus

B7JJT6, Q81WI8,

anthracis, Bacillus cereus, Bacillus

C3L778, B9IVD8,

anthracis, Bacillus anthracis, Bacillus

B7HLI2, Q732M1,

cereus, Bacillus cereus, Bacillus

Q636H7, A7GRH9,

cereus, Bacillus cereus, Bacillus

Q38XR8, Q5WFM6,

cytotoxicus, Lactobacillus sakei,

Q9PM40, A8FNU7,

Bacillus clausii, Campylobacter jejuni,

A7H5Y2, Q5HSF8,

Campylobacter jejuni, Campylobacter

A8Z6F6, A0RRM7,

jejuni, Campylobacter jejuni,

A7H186, Q97IA4,

Campylobacter concisus,

Q4JUY7, Q8FP16,

Campylobacter fetus, Campylobacter

Q8NNV6, Q82ZG1,

curvus, Clostridium acetobutylicum,

B6JLQ0, Q7VIA9,

Corynebacterium jeikeium,

Q9ZLH2, P56118,

Corynebacterium efficiens,

B5Z735, Q17XJ6,

Corynebacterium glutamicum,

B2UTG4, Q8Y691,

Enterococcus faecalis, Helicobacter

A0AJR0, B8DDU8,

pylori, Helicobacter hepaticus,

Q71YL2, ClKWA4,

Helicobacter pylori, Helicobacter

Q92AK3

pylori, Helicobacter pylori,

Helicobacter acinonychis,

Helicobacter pylori, Listeria

monocytogenes, Listeria welshimeri,

Listeria monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Listeria innocua

1388
NEWDPLEEV

Streptomyces griseus

P29780
P50440

1389
NEWDPLEEVIVG

Streptomyces griseus

P08078
P50440

1390
NFCANNYLGL

Escherichia coli, Escherichia coli

P0AB77, P0AB78
O75600

1391
NFGPQHPAAHGV

Neisseria gonorrhoeae, Neisseria

B4RPI1, Q5F618,
O75306

LR

gonorrhoeae, Neisseria meningitidis,

Q9K1C0, A1KRS5,

Neisseria meningitidis, Neisseria

A1INN7, A9M3D9,

meningitidis, Neisseria meningitidis,

A5VAM0

Sphingomonas wittichii

1392
NFGPQHPAAHGV

Stenotrophomonas maltophilia,

B4SQT3, B2FNX6
O75306

LRL

Stenotrophomonas maltophilia

1393
NFGPQHPAAHGV

Methylobacterium sp.,
B0ULK7, B1ZA43,
O75306

LRLV

Methylobacterium populi,

A9W1N0, B1LUN4,

Methylobacterium extorquens,

Q2K9T1, B5ZYL5,

Methylobacterium radiotolerans,

B3PW00, Q1MIL2,

Rhizobium etli, Rhizobium

Q98KQ8, P56907

leguminosarum, Rhizobium etli,

Rhizobium leguminosarum,

Rhizobium loti, Rhizobium meliloti

1394
NGAFTGEISP

Bacillus clausii, Bacillus cytotoxicus,

Q5WDK7, A7GUR9,
P60174

Bacillus pumilus, Bacillus

A8FHJ2, A7Z8Y3,

methylotrophicus, Bacillus

A9VQ50, Q72XY3,

weihenstephanensis, Bacillus cereus,

B7JFG5, B7HW54,

Bacillus cereus, Bacillus cereus,

Q81X76, Q6HBF1,

Bacillus anthracis, Bacillus

Q631M0, Q4MQ55,

thuringiensis, Bacillus cereus, Bacillus

P60180, B7HED4,

cereus, Bacillus cereus, Bacillus

B7IP22

cereus, Bacillus cereus

1395
NGAGKSTLL

Geobacter sulfurreducens

Q74DN5
Q8WWZ4

1396
NGAGKSTTI

Bacillus subtilis

P55339
Q8IUA7

1397
NGAGKTTTF

Bacillus subtilis, Bacillus

C0SPB4, P26946
Q99758

pseudofirmus

1398
NGAGKTTTI

Bacillus licheniformis

P42332
Q86UK0

1399
NGIVHRDIKP

Clostridium acetobutylicum

Q97IC2
Q14164

1400
NGKDYYFVTRE

Lactobacillus delbrueckii

Q1G9H8
Q16774

1401
NGKVALVTGAA

Pseudomonas aeruginosa

Q51576
P15428

1402
NGLANPRDFL

Pseudomonas aeruginosa,

Q9X4G0, B7VA96,
Q93099

Pseudomonas aeruginosa,

Q02LF6, A6V6F5,

Pseudomonas aeruginosa,

Q4KI35, Q1I500,

Pseudomonas aeruginosa,

B0KGU6, Q88E47,

Pseudomonas fluorescens,

Q6EMI9, A5W8Z1,

Pseudomonas entomophila,

B1J390, Q3KHV3,

Pseudomonas putida, Pseudomonas

Q48GS7, Q87Z79,

putida, Pseudomonas putida,

B2UJ73, Q8XRZ0

Pseudomonas putida, Pseudomonas

putida, Pseudomonas fluorescens,

Pseudomonas savastanoi,

Pseudomonas syringae, Ralstonia

pickettii, Ralstonia solanacearum

1403
NGMDVFRVFD

Klebsiella pneumoniae

P13187
P11498

1404
NGNEIGGGSIRIH

Corynebacterium urealyticum,

B1VDL1, C3PGN5,
Q6PI48

Corynebacterium aurimucosum,

Q4JVF2, Q8NQ19,

Corynebacterium jeikeium,

A4QEL0, Q8FT19,

Corynebacterium glutamicum,

C5CCH2

Corynebacterium glutamicum,

Corynebacterium efficiens,

Micrococcus luteus

1405
NHPDLRRIL

Geobacter metallireducens,

Q39QA9, Q74GA6
O75489

Geobacter sulfurreducens

1406
NHPDLRRILTDYG

Neisseria meningitidis, Neisseria

Q9K1C1, Q9JX80,
O75489

F

meningitidis, Neisseria meningitidis,

A1KRS4, A9M3E0,

Neisseria meningitidis, Neisseria

B4RPI2, Q5F617

gonorrhoeae, Neisseria gonorrhoeae

1407
NIGIGGSDLG

Campylobacter jejuni, Helicobacter

A7H491, Q17W92,
P06744

acinonychis, Helicobacter pylori,

B2UUS4, Q9ZK49,

Helicobacter pylori, Helicobacter

Q25781, B6JNO6,

pylori, Helicobacter pylori,

Q1CSA0, B5Z8G1

Helicobacter pylori, Helicobacter

pylori

1408
NIGIGGSDLGP

Bifidobacterium longum,

Q8G7I6, Q6NIE5,
P06744

Corynebacterium diphtheriae,

A4QCJ4, Q8NS31,

Corynebacterium glutamicum,

Q8FR39, C4LHE0,

Corynebacterium glutamicum,

Q4JX51, Q8XYN9,

Corynebacterium efficiens,

Q98BV5, B1W0Z7,

Corynebacterium kropnstedtii,

Q9Z523, Q82M90,

Corynebacterium jeikeium, Ralstonia

O88015, B1H069

solanacearum, Rhizobium loti,

Streptomyces griseus, Streptomyces

coelicolor, Streptomyces avermitilis,

Streptomyces coelicolor, Uncultured

termite

1409
NIIDTPGHVDFT

Bacillus pumilus, Bacillus

A8F981, Q65PB0,
Q96RP9

licheniformis, Bacillus

A7Z0N4, P80868,

methylotrophicus, Bacillus subtilis,

A9VP74, Q814C5,

Bacillus weihenstephanensis, Bacillus

B7HJ45, A7GK17,

cereus, Bacillus cereus, Bacillus

C3LJ79, Q63H93,

cytotoxicus, Bacillus anthracis,

Q6HPR1, C1ET36,

Bacillus cereus, Bacillus thuringiensis,

Q81VT3, C3P9Q2,

Bacillus cereus, Bacillus anthracis,

B9IZJ1, B7HQU1,

Bacillus anthracis, Bacillus cereus,

Q73F99, B7IT16,

Bacillus cereus, Bacillus cereus,

B7JKB6, B1IGF7,

Bacillus cereus, Bacillus cereus,

A7GJ77, A5I7K9,

Clostridium botulinum, Clostridium

A7FZ72, C3KVQ4,

botulinum, Clostridium botulinum,

B1KSM8, C1FMV4,

Clostridium botulinum, Clostridium

A6LPQ8, Q0SQE1,

botulinum, Clostridium botulinum,

Q8XHS1, Q0TMP3,

Clostridium botulinum, Clostridium

Q8NT19, A4QBG9,

beijerinckii, Clostridium perfringens,

Q6NJD6, Q92715,

Clostridium perfringens, Clostridium

A0ALY9, Q8Y421,

perfringens, Corynebacterium

B8DAY6, C1KZK7,

glutamicum, Corynebacterium

Q71WB8, B1GZ80

glutamicum, Corynebacterium

diphtheriae, Listeria innocua, Listeria

welshimeri, Listeria monocytogenes,

Listeria monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Uncultured termite

1410
NIIDTPGHVDFTIE

Streptococcus suis, Streptococcus

A4VSN3, A4VYX6,
Q96RP9

V

suis, Streptococcus agalactiae,

Q8E3E7, Q03IS1,

Streptococcus thermophilus,

Q5M2M6, Q5LY21,

Streptococcus thermophilus,

Q8DXS7, Q3JZB5,

Streptococcus thermophilus,

A3CQM2, A8AUR6,

Streptococcus agalactiae,

C1CIF3, Q8DW4,

Streptococcus agalactiae,

C1CPE5, B2ISJ9,

Streptococcus sanguinis,

B8ZKU0, C1CC62,

Streptococcus gordonii,

P64023, P64022,

Streptococcus pneumoniae,

B1I8Z9, C1CB46,

Streptococcus mutans, Streptococcus

B5E6U5, Q04MH7

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae

1411
NIIDTPGHVDFTIE

Lactobacillus sakei, Lactobacillus

Q38UQ9, B3WAM2,
Q96RP9

VER

casei, Lactobacillus casei,

Q034X8, B8IS82,

Methylobacterium nodulans,

B1ZLK1, Q748Y8,

Methylobacterium populi, Geobacter

Q9I244, Q88FI4,

sulfurreducens, Pseudomonas

Q1MIE4, B5ZYT2,

aeruginosa, Pseudomonas putida,

B3PWR8, Q2K9L9,

Rhizobium leguminosarum,

C3MAX7, Q920H2

Rhizobium leguminosarum,

Rhizobium etli, Rhizobium etli,

Rhizobium sp., Rhizobium meliloti

1412
NIRNFSIVAH

Methylobacterium extorquens,

B7KR78, B1ZC10
Q8N442

Methylobacterium populi

1413
NKEIFLREL

Helicobacter pylori, Ralstonia

P56116, Q8Y0Q3
P14625

solanacearum

1414
NKEIFLRELISNA

Fusobacterium nucleatum

Q8RGH4
P14625

1415
NKEIFLRELISNAS

Aggregatibacter

P54649, A8AJX0,
P14625

DA

actinomycetemcomitans, Citrobacter

Q894P6, Q97E05,

koseri, Clostridium tetani, Clostridium

A4W7F7, P0A6Z3,

acetobutylicum, Enterobacter sp.,
P0A6Z4, B1IZC1,

Escherichia coli, Escherichia coli,

Q0TKG8, A7ZXD1,

Escherichia coli, Escherichia coli,

P0A6Z5, Q1RF62,

Escherichia coli, Escherichia coli,

A1A8D9, A7ZIN3,

Escherichia coli, Escherichia coli,

B8F5X3, A5UFQ9,

Escherichia coli, Haemophilus

Q4QP81, A5UB42,

parasuis, Haemophilus influenzae,

Q0I2A3, P44516,

Haemophilus influenzae,

A6T5N6, Q9I3C5,

Haemophilus influenzae,

A4XV81, A6V7J7,

Haemophilus somnus, Haemophilus

Q48K64, Q4ZUW2,

influenzae, Klebsiella pneumoniae,

Q88FB9, Q4KFX8,

Pseudomonas aeruginosa,

Q883Y9, Q3KFT8,

Pseudomonas mendocina,

C3K6N7

Pseudomonas aeruginosa,

Pseudomonas savastanoi,

Pseudomonas syringae,

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas fluorescens

1416
NKEIFLRELISNAS

Campylobacter hominis,

A7I226, A1VYN0,
P14625

DALDK

Campylobacter jejuni, Campylobacter

Q9PHZ3, A8FKU4,

jejuni, Campylobacter jejuni,

A7H4M0, Q5HVP5

Campylobacter jejuni, Campylobacter

jejuni

1417
NKEPGAEEK

Streptococcus thermophilus,

Q5M6D0, Q5M1T7,
P25685

Streptococcus thermophilus,

Q8DWH2

Streptococcus mutans

1418
NKYSEGYPG

Lactobacillus plantarum

Q88UT5
P34896

1419
NLDEFAMGS

Lactobacillus fermentum,

B2GDS6, B1ZLM1,
Q9H0R6

Methylobacterium populi,

A9W748, B7KWB0

Methylobacterium extorquens,

Methylobacterium extorquens

1420
NLFAIIQGG

Helicobacter acinonychis

Q17YB5
Q9BXR0

1421
NLGFSPEDR

Staphylococcus carnosus,

B9DLK2, Q49UM5
O43252

Staphylococcus saprophyticus

1422
NLIGEHTDYN

Lactobacillus plantarum, Lactobacillus

Q885E8, Q1WUZ4,
P51570

salivarius, Lactobacillus casei,

O84902, B3W7I5,

Lactobacillus casei, Lactobacillus

Q03BB8, Q836P0,

casei, Enterococcus faecalis,

Q49ZK2, Q9RGS1,

Staphylococcus saprophyticus,

Q8DNK7, Q97NZ6,

Staphylococcus carnosus,

Q9ZB10, Q5LYY7,

Streptococcus pneumoniae,

Q03JS8, P96993,

Streptococcus pneumoniae,

A4VT88, P13227

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus mutans, Streptococcus

suis, Streptomyces lividans

1423
NLMELLIMI

Clostridium perfringens, Listeria

Q8XHJ4, Q92F68,
P11908

innocua, Listeria monocytogenes,

Q48793, Q724L4,

Listeria monocytogenes, Listeria

Q83TK1, Q83YI7

welshimeri, Listeria ivanovii

1424
NLSGGQKQR

Lactobacillus delbrueckii

Q04BY7
Q92887

1425
NLSPNGGGEP

Corynebacterium diphtheriae

P42821
P04179

1426
NMILDDGGD

Methylobacterium sp.,
B0UM37, B8IPU4,
P23526

Methylobacterium nodulans,

B1ZLX0, A9VYP7,

Methylobacterium populi,

B7KSJ4

Methylobacterium extorquens,

Methylobacterium extorquens

1427
NPAFDVTPH

Bacillus pumilus

A8FCG5
Q9BV20

1428
NPETVSTDF

Bacillus cytotoxicus, Bacillus cereus,

A7GRL1, B7JJX3,
P31327

Bacillus cereus, Bacillus cereus,

Q732I3, B7IUP6,

Bacillus cereus, Bacillus cereus,

B9IVW3, B7HLM0,

Bacillus thuringiensis, Bacillus

Q6HE58, C3P656,

anthracis, Bacillus anthracis, Bacillus

Q81WF2, C3L740,

anthracis, Bacillus cereus, Bacillus

C1EPQ0, A0RHQ8,

thuringiensis, Bacillus

A9VTC6, Q636E0,

weihenstephanensis, Bacillus cereus,

Q819S3, B7H6M2,

Bacillus cereus, Bacillus cereus,

Q9K9V9, Q38X24,

Bacillus halodurans, Lactobacillus

Q1WVA9, P77886,

sakei, Lactobacillus salivarius,

Q9RLS9, Q6A914,

Lactobacillus plantarum, Lactobacillus

Q834E2, Q03WW7,

plantarum, Propionibacterium acnes,

B1MZ74, Q92AH3,

Enterococcus faecalis, Leuconostoc

Q71YI1, A0AJU0,

mesenteroides, Leuconostoc citreum,

Q8Y665, B8DDR7,

Listeria innocua, Listeria

C1KWD4, Q03HB0,

monocytogenes, Listeria welshimeri,

Q5M0W9, Q5M5F6,

Listeria monocytogenes, Listeria

Q03LT8, Q3K150,

monocytogenes, Listeria

Q8E5F5, Q8DZQ7,

monocytogenes, Pediococcus

C10EM9, B1I065,

ntosaceus, Streptococcus

B5E512, C1C7Q3,

thermophilus, Streptococcus

B8ZJT9, B2IQ67,

thermophilus, Streptococcus

Q8CVVR0, Q970E4,

thermophilus, Streptococcus

C1CR31, Q04K48,

agalactiae, Streptococcus agalactiae,

C1CL09, Q8DUP3,

Streptococcus agalactiae,

A3CNI5, C0MEH1,

Streptococcus pneumoniae,

A8AX83, A2RF60,

Streptococcus pneumoniae,

B5XKW2, Q9A006,

Streptococcus pneumoniae,

Q5XCR6, P0DA15,

Streptococcus pneumoniae,

P0DA14, P58941,

Streptococcus pneumoniae,

C0M756

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus mutans, Streptococcus

sanguinis, Streptococcus equi,

Streptococcus gordonii,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus equi

1429
NPETVSTDFD

Clostridium acetobutylicum,

Q97FT3, A6LPD9
P31327

Clostridium beijerinckii

1430
NPFDLTKVWPH

Proteus mirabilis

P42321
P04040

1431
NPGDGAFYGPK

Fusobacterium nucleatum

Q8RF56
A2RTX5

1432
NPTYKEVCS

Listeria welshimeri, Listeria

A0AJW5, Q8Y640,
Q9UJ68

monocytogenes, Listeria

B8DDP2, Q71YF6,

monocytogenes, Listeria

C1KWF9, Q92AE8,

monocytogenes, Listeria

Q8DYH1, Q3K013,

monocytogenes, Listeria innocua,

Q8E434

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae

1433
NPVDILTYV

Bacillus cereus, Bacillus thuringiensis,

Q632G8, Q6HC14,
Q9BYZ2

Bacillus anthracis, Bacillus cereus,

Q81K80, Q816G3,

Bacillus cereus, Bacillus thuringiensis,

P62048, Q6HK31,

Bacillus cereus, Bacillus cereus,

Q63CN1, P62047,

Bacillus anthracis, Bacillus cereus,

Q81RW4, Q81EP4,

Clostridium thermocellum

Q8KQC4

1434
NPVPVMKLVEVI

Bacillus subtilis

P45856
Q16836

1435
NQIVHRDIK

Bacillus subtilis

O34507
Q99683

1436
NQRETTVIWDK

Lactobacillus sakei, Pediococcus

Q38XX6, Q03DS8,
Q14410

ntosaceus, Staphylococcus

Q4L607, P0DA17,

haemolyticus, Streptococcus

P0DA16, B9DV90

pyogenes, Streptococcus pyogenes,

Streptococcus uberis

1437
NQRETTVVW

Aeromonas hydrophila, Aeromonas

A0KIT3, A4SPA7,
Q14409

salmonicida, Clostridium botulinum,

C1FUW6, A7GH02,

Clostridium botulinum, Clostridium

B1IKJ7, C3L254,

botulinum, Clostridium botulinum,

B1KYK0, A5I5M0,

Clostridium botulinum, Clostridium

A7FX30, C6E1L8,

botulinum, Clostridium botulinum,

B5EB79, Q8XUY1

Geobacter sp., Geobacter

bemidjiensis, Ralstonia solanacearum

1438
NQRETTVVWD

Desulfovibrio alaskensis, Geobacter

Q316D5, Q749I1,
O14409

sulfurreducens, Geobacter lovleyi,

B3E6Z6, Q51390,

Pseudomonas aeruginosa,

B4SJT3, B2FI02,

Stenotrophomonas maltophilia,

Q9RJM2, Q826J2

Stenotrophomonas maltophilia,

Streptomyces coelicolor,

Streptomyces avermitilis

1439
NQRETTVVWDK

Acinetobacter baylyi, Bacillus cereus,

Q6FDN3, B7IKB1,
Q14409

Bacillus cereus, Bacillus cereus,

Q81GZ2, B7HG04,

Bacillus methylotrophicus, Bacillus

A7Z2U3, P18157,

subtilis, Bacillus licheniformis,

Q65M11, Q88YD9,

Lactobacillus plantarum, Lactobacillus

Q047N5, B8FXS7,

delbrueckii, Desulfitobacterium

C4LGQ3, Q8NLP9,

hafniense, Corynebacterium

A4QHT1, C6C1M7,

kropnstedtii, Corynebacterium

B8DL62, C4XGV9,

glutamicum, Corynebacterium

A1VA10, Q726H4,

glutamicum, Desulfovibrio salexigens,

O34153, O34154,

Desulfovibrio vulgaris, Desulfovibrio

Q88NX8, Q3K7I5,

maeticus, Desulfovibrio vulgaris,

A5VZG7, Q4K734,

Desulfovibrio vulgaris, Enterococcus

Q1IE16, B0KUG0,

casseliflavus, Enterococcus faecalis,

C3KBM0, O87924,

Pseudomonas putida, Pseudomonas

A8Z1X0, A6QGJ8,

fluorescens, Pseudomonas putida,

Q5HGD2, Q2FYZ5,

Pseudomonas fluorescens,

Q2FHD9, P99113,

Pseudomonas entomophila,

P63741, A5IS12,

Pseudomonas putida, Pseudomonas

A6U1B8, A7X1U3,

fluorescens, Pseudomonas tolaasii,

Q6GHD5, Q2YXR6,

Staphylococcus aureus,

Q8NWX7, Q6G9R3,

Staphylococcus aureus,

Q5HPP1, Q8CSS0,

Staphylococcus aureus,

Q49X93, Q8NZW9,

Staphylococcus aureus,

Q1J5E4, B5XMM6,

Staphylococcus aureus,

A2RD27, Q1JFJ5,

Staphylococcus aureus,

Q1JKK3, Q1JAF2,

Staphylococcus aureus,

Q99YI7, Q48RX6,

Staphylococcus aureus,

Q5XAJ9, B5E357,

Staphylococcus aureus,

Q8E1T0, Q3K3A6,

Staphylococcus aureus,

Q8E794, C1CNF8,

Staphylococcus aureus,

B1I9Z6, B8ZQ22,

Staphylococcus aureus,

C1CUA3, C1CHI6,

Staphylococcus aureus,

P63743, B2INK5,

Staphylococcus aureus,

P63742, Q04HZ0,

Staphylococcus epidermidis,

C1CBG2, A3CPV3,

Staphylococcus epidermidis,

A8AVX5

Staphylococcus saprophyticus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus sanguinis,

Streptococcus gordonii

1440
NRDHRKIGK

Acinetobacter baumannii

B0VKJ4
A2RTX5

1441
NRKVLADLA

Parabacteroides distasonis,

A6L955, Q5LEQ3,
Q9BYC9

Bacteroides fragilis, Bacteroides

Q64VN9, Q7MVQ8

fragilis, Porphyromonas gingivalis

1442
NRLGANSLL

Bacillus subtilis

P08065
P31040

1443
NRPKALNAL

Clostridium acetobutylicum

P52046
P30084

1444
NRSASIRIP

Escherichia coli, Escherichia coli,

P0A9C6, P0A9C7,
P15104

Escherichia coli, Haemophilus

P0A9C5, P43794,

influenzae, Neisseria gonorrhoeae,

P25821, P28786,

Proteus hauseri, Pseudomonas

Q9HU65, Q3V5W6

aeruginosa, Pseudomonas taetrolens

1445
NSAVFPGLQGGP

Ralstonia solanacearum, Rhizobium

Q8XTQ1, Q9Q0U6,
P34896

meliloti, Rhizobium leguminosarum,

Q1MIU5, Q983B6,

Rhizobium loti, Rhizobium etli,

Q2KA25, Q92XS8,

Rhizobium meliloti, Sphingomonas

A5V5D1, Q5M4W1

wittichii, Streptococcus thermophilus

1446
NSFGFGGTNATL

Escherichia coli, Escherichia coli,

P0A954, P0A953,
Q9NWU1

Haemophilus influenzae,

P43710, Q02K94

Pseudomonas aeruginosa

1447
NTARGGLVDE

Methylobacterium extorquens

Q59516
Q13363

1448
NTDAEGRLIL

Desulfovibrio alaskensis, Neisseria

Q315M7, Q9JTI8,
P28838

meningitidis, Ralstonia pickettii,

B2UAK8, Q8XWQ8,

Ralstonia solanacearum,

B2FMS4, B4SJ73

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1449
NTDAEGRLILADA

Corynebacterium glutamicum,

Q8NNJ4, Q8FNP8
P28838

Corynebacterium efficiens

1450
NTDAEGRLVL

Acinetobacter baumannii,

B0VMG3, B2I1U0,
Q8NDH3

Acinetobacter baumannii,

A3M1A8, B0VDC8,

Acinetobacter baumannii,

B71309, B7H1P9,

Acinetobacter baumannii,

Q6FFD8, C5BBY4,

Acinetobacter baumannii,

Q7VNH9, B8F6N9,

Acinetobacter baumannii,

A5UBH1, Q4QJN7,

Acinetobacter baylyi, Edwardsiella

P45334, Q0I236,

ictaluri, Haemophilus ducreyi,

A5UFE2, Q7VGF0,

Haemophilus parasuis, Haemophilus

C3K6G5, B1JBA9,

influenzae, Haemophilus influenzae,

Q88P73, Q3KHM4,

Haemophilus influenzae,

B0KQK8, A5VZ69,

Haemophilus somnus, Haemophilus

Q86436, Q1I5F9,

influenzae, Helicobacter hepaticus,

Q4ZXH7, B7UVT6,

Pseudomonas fluorescens,

O68822, A6V0T2,

Pseudomonas putida, Pseudomonas

Q02RY8, Q887M0,

putida, Pseudomonas fluorescens,

A4VNZ7, Q1MIZ4,

Pseudomonas putida, Pseudomonas

B5ZWY7, Q2KA77,

putida, Pseudomonas putida,

B3PUV3, Q92QY7,

Pseudomonas entomophila,

C3M9C8, B9DIX2

Pseudomonas syringae,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas syringae,

Pseudomonas stutzeri, Rhizobium

leguminosarum, Rhizobium

leguminosarum, Rhizobium etli,

Rhizobium etli, Rhizobium meliloti,

Rhizobium sp., Staphylococcus

carnosus

1451
NTDAEGRLVLAD

Campylobacter jejuni,

Q9PP04, Q6NG90,
Q8NDH3

Corynebacterium diphtheriae,

Q17W06, B5Z6U1,

Helicobacter acinonychis,

O25294, B6JLF2,

Helicobacter pylori, Helicobacter

Q9ZLR1, Q1CTV6,

pylori, Helicobacter pylori,

B2UTQ8, Q984S1,

Helicobacter pylori, Helicobacter

Q82AN2, B1VZN5,

pylori, Helicobacter pylori, Rhizobium

Q9S2Q7

loti, Streptomyces avermitilis,

Streptomyces griseus, Streptomyces

coelicolor

1452
NTDAEGRLVLADG

Bacillus methylotrophicus, Bacillus

A7Z8B5, O32106,
Q8NDH3

subtilis, Enterobacter sp.
A4WDA4

1453
NTDAEGRLVLADG

Bacillus pumilus

A8FH04
Q8NDH3

V

1454
NTDNMSILGLTIDY

Enterobacter sp., Klebsiella
A4W9N5, A6TAH1,
Q9BVL4

GP

pneumoniae, Klebsiella pneumoniae

B5XQE2

1455
NTFVAELKG

Citrobacter koseri, Enterobacter sp.,
A8AQC8, A4WF48,
P40926

Escherichia coli, Escherichia coli,

Q1R6A3, P61889,

Escherichia coli, Escherichia coli,

P61890, B1XHK9,

Escherichia coli, Escherichia coli,

A1AGC9, A8A545,

Escherichia coli, Escherichia coli,

C4ZSX4, B7N0M1,

Escherichia coli, Escherichia coli,

B5YSW2, P61891,

Escherichia coli, Escherichia coli,

B7MBZ7, A7ZSD0,

Escherichia coli, Escherichia coli,

B7UJW8, B7M0U8,

Escherichia coli, Escherichia coli,

B7LHU4, Q0TCN0,

Escherichia coli, Escherichia coli,

B1IQP3, B1LGK2,

Escherichia coli, Escherichia coli,

B7NKU9, B6I1V4,

Escherichia fergusonii, Escherichia

B7LRL0, B7NDL4,

coli, Klebsiella pneumoniae, Klebsiella

A6TEQ3, B5XSQ7,

pneumoniae, Klebsiella variicola,

P61896, P61894,

Klebsiella oxytoca, Raoultella

P61895

terrigena

1456
NVGKSSIIN

Clostridium cellulolyticum

B8I8N7
Q9BVP2

1457
NVGKSSIINSL

Clostridium perfringens, Clostridium

Q8XKK5, Q0TQK6,
Q9BVP2

perfringens, Clostridium perfringens

Q0ST57

1458
NVGKSSLIN

Lactobacillus casei, Lactobacillus

B3WE42, Q039K2,
Q9NVN8

casei, Lactobacillus acidophilus,

Q5FKR5, Q042T8,

Lactobacillus gasseri, Lactobacillus

A8YUS5, Q38WS0,

helveticus, Lactobacillus sakei,

Q8RHK1, Q5LDL2,

Fusobacterium nucleatum,

Q64UN4, A6L4J3,

Bacteroides fragilis, Bacteroides

Q8A8T4, A5N2K5,

fragilis, Bacteroides vulgatus,

Q97FU0, C4Z1T3,

Bacteroides thetaiotaomicron,

Q748I9, B9LZU0,

Clostridium kluyveri, Clostridium

Q39YG6, A5G964,

acetobutylicum, Eubacterium eligens,

B3E2D1, Q92SF6

Geobacter sulfurreducens, Geobacter

daltonii, Geobacter metallireducens,

Geobacter uraniireducens, Geobacter

lovleyi, Rhizobium meliloti

1459
NVGKSSLINGL

Clostridium phytofermentans

A9KHA0
P36915

1460
NVGKSSLINSL

Clostridium botulinum, Clostridium

B2TPB6, A6LT31,
Q9NVN8

beijerinckii, Clostridium botulinum

B2UX10

1461
NVGTIGHVDHG

Pseudomonas syringae

Q889X3
P49411

1462
PAKSGVAGG

Corynebacterium glutamicum

Q8NMT3
O94925

1463
PAKSGVAGGI

Bacillus cytotoxicus, Bacillus

A7GKX3, A9VSP6,
O94925

weihenstephanensis, Bacillus cereus,

Q81I63, C1EWD5,

Bacillus cereus, Bacillus cereus,

Q73E07, Q81YY0

Bacillus anthracis

1464
PCGACRQVM

Bacillus halodurans

Q9KD53
P32320

1465
PCGTTIGPI

Streptomyces coelicolor,

Q9XA76, Q82F74
Q9ULA0

Streptomyces avermitilis

1466
PDGGIARLRV

Streptomyces coelicolor,

Q9RKU4, Q82LL5
Q8N6M5

Streptomyces avermitilis

1467
PDGGVSRLR

Pseudomonas syringae,

Q4ZVG8, C3K0A7,
Q8N6M5

Pseudomonas fluorescens,

Q48KS4, Q87YX4,

Pseudomonas savastanoi,

Q3KFK9

Pseudomonas syringae,

Pseudomonas fluorescens

1468
PDGGVSRLRL

Pseudomonas fluorescens,

Q4K8H3, A4VP32
Q8N6M5

Pseudomonas stutzeri

1469
PDIVTMAKG

Bilophila wadsworthia

Q9APM5
Q9BYV1

1470
PDKDVDGFH

Citrobacter koseri, Edwardsiella

A8AJS4, C5B8V3,
P13995

ictaluri, Enterobacter sp., Escherichia
A4W7J0, B7LJI7,

fergusonii, Escherichia coli,

C4ZUX7, P24186,

Escherichia coli, Escherichia coli,

B1IZ72, B1XGC7,

Escherichia coli, Escherichia coli,

B7M4N2, B7L7F6,

Escherichia coli, Escherichia coli,

B6I0H4, A7ZIT8,

Escherichia coli, Escherichia coli,

B7N983, B1LKE8,

Escherichia coli, Escherichia coli,

B7NL23, B7MRJ2,

Escherichia coli, Escherichia coli,

Q1RF04, Q8FK41,

Escherichia coli, Escherichia coli,

Q0TKB2, Q8XCT6,

Escherichia coli, Escherichia coli,

B5YPP4, A1A8J4,

Escherichia coli, Escherichia coli,

A7ZXI3, B7ME52,

Escherichia coli, Escherichia coli,

B7UKK6, A6T5R4,

Klebsiella pneumoniae, Klebsiella

B5Y0K4, B4F1G5,

pneumoniae, Proteus mirabilis,

Q3K9W7, Q02KT7,

Pseudomonas fluorescens,

Q9I2U6, B7VB83,

Pseudomonas aeruginosa,

Q4K9J4, Q4ZUA4,

Pseudomonas aeruginosa,

B1J675, Q1ICB3,

Pseudomonas aeruginosa,

A5W638, Q88KM5,

Pseudomonas fluorescens,

Q48KZ8, A6V726,

Pseudomonas syringae,

B0KJG3, Q4ZVN1,

Pseudomonas putida, Pseudomonas

Q87YR0, A4VL74,

entomophila, Pseudomonas putida,

Q2YX11, Q6GI21

Pseudomonas putida, Pseudomonas

savastanoi, Pseudomonas

aeruginosa, Pseudomonas putida,

Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas stutzeri,

Staphylococcus aureus,

Staphylococcus aureus

1471
PDNYKVIFLQGG

Streptococcus agalactiae

Q8E3Y3
Q9Y617

1472
PEEKRKIIG

Campylobacter hominis,

A7I131, Q02R52,
P49915

Pseudomonas aeruginosa,

Q9HXM6, B7UXJ9,

Pseudomonas aeruginosa,

Q82HM9

Pseudomonas aeruginosa,

Streptomyces avermitilis

1473
PEGATPKDGPSA

Fusobacterium nucleatum

Q8RHK0
P36776

G

1474
PEGLAVSLP

Campylobacter jejuni

Q9PIN2
Q8N155

1475
PEKDVDGFH

Lactobacillus fermentum

B2GD67
Q9H903

1476
PERWHAKGAGA

Bacillus subtilis

P26901
P04040

1477
PFDLTKVWP

Neisseria gonorrhoeae

Q59602
P04040

1478
PFGGFKMSG

Bacillus licheniformis, Bacillus

Q65NN2, Q9K9B2,
O94788

halodurans, Bacillus subtilis, Bacillus

P94391, Q9K5Z5,

halodurans, Bacillus pumilus,

A8F9T1, A8Z3F5,

Staphylococcus aureus,

A5IVY0, A6QK44,

Staphylococcus aureus,

Q6GDP4, P99076,

Staphylococcus aureus,

A6U4T5, P63939,

Staphylococcus aureus,

Q5HCZ6, Q2YWA6,

Staphylococcus aureus,

Q2FV67, Q2FDV3,

Staphylococcus aureus,

A7X6R7, Q8NUR2,

Staphylococcus aureus,

Q4A0E7, Q6G6C0,

Staphylococcus aureus,

Q8CN04, Q5HL59

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1479
PFGGVGASG

Acinetobacter baylyi, Citrobacter

Q6FCQ0, A8AHD8,
P43353

koseri, Enterobacter sp., Escherichia
A4W9J7, B7L046,

fergusonii, Pseudomonas

Q1I6Z5, Q4K837,

entomophila, Pseudomonas

Q48G19, C3JXY7,

fluorescens, Pseudomonas

Q885J7, A5W0D5,

savastanoi, Pseudomonas

Q88EI4, B0KR47,

fluorescens, Pseudomonas syringae,

Q4ZQH8, Q3K885

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas syringae,

Pseudomonas fluorescens

1480
PFGGYKKSG

Staphylococcus haemolyticus

Q4L919
P49189

1481
PFNFPAMIPLWMF

Pseudomonas aeruginosa

P28810
Q02252

P

1482
PFNIASYALL

Porphyromonas gingivalis

Q7MTB5
P04818

1483
PFPGPGLAIR

Propionibacterium acnes

Q6A6X1
P49915

1484
PFPGPGLAIRV

Lactobacillus gasseri, Clostridium

Q046I2, B9DYY7,
P49915

kluyveri, Clostridium kluyveri,

A5N5D9, Q8XI46,

Clostridium perfringens, Clostridium

A6L090, A0Q2S8,

beijerinckii, Clostridium novyi,

C3KUC5, A5I720,

Clostridium botulinum, Clostridium

A7FYP0, A7GIN0,

botulinum, Clostridium botulinum,

B1IFD1, B1L1J7,

Clostridium botulinum, Clostridium

C1FLV2, C1CF29,

botulinum, Clostridium botulinum,

B8ZKZ5, B1ICM9,

Clostridium botulinum, Streptococcus

P64298, C1CQS0,

pneumoniae, Streptococcus

C1C842, P64297,

pneumoniae, Streptococcus

B5E5U0, Q04JQ8,

pneumoniae, Streptococcus

C1CLE8, B2IQR1

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae

1485
PFPGPGLAIRVI

Lactobacillus delbrueckii,

Q1GBU7, Q04CA4
P49915

Lactobacillus delbrueckii

1486
PFRLGLGGPIGSG

Escherichia coli

P77775
Q9NRG7

1487
PFSMGPLGS

Acinetobacter baylyi, Acinetobacter

Q6F8P2, B0VSN6,
P35558

baumannii, Acinetobacter baumannii,

B2HXC1, A3M840,

Acinetobacter baumannii,

B7GY31, B0VDR1,

Acinetobacter baumannii,

B7I624

Acinetobacter baumannii,

Acinetobacter baumannii

1488
PFSMGPLGSP

Ralstonia solanacearum, Ralstonia

Q8Y3G3, B2U804
P35558

pickettii

1489
PGAGGTQRL

Escherichia coli

P76082
P30084

1490
PGAGKGTQA

Aeromonas hydrophila, Aeromonas

A0KL52, A4SLY1,
P54819

salmonicida, Bacillus halodurans,

P38372, Q5WLP1,

Bacillus clausii, Bacillus cytotoxicus,

A7GK41, B7HJ69,

Bacillus cereus, Bacillus cereus,

Q81J22, B7HQW5,

Bacillus cereus, Bacillus cereus,

B9IZL5, Q73F75,

Bacillus cereus, Bacillus

A9VP98, B7IT40,

weihenstephanensis, Bacillus cereus,

Q81VQ9, Q6HPN7,

Bacillus anthracis, Bacillus

B7JKE1, C3P9S6,

thuringiensis, Bacillus cereus, Bacillus

A0R8K1, Q63H69,

anthracis, Bacillus thuringiensis,

C1ET60, C3LJA3,

Bacillus cereus, Bacillus cereus,

P35140, A8F9A6,

Bacillus anthracis, Bacillus

B3WAJ7, B2G8V7,

licheniformis, Bacillus pumilus,

B2GDU8, C4ZBT9,

Lactobacillus casei, Lactobacillus

Q8RE31, C4Z2V1,

reuteri, Lactobacillus fermentum,

Q6A6Q4, A8AJW9,

Eubacterium rectale, Fusobacterium

A3DJJ3, A9KJH3,

nucleatum, Eubacterium eligens,

B8I800, C5BD16,

Propionibacterium acnes, Citrobacter

A4W7F8, Q8FK84,

koseri, Clostridium thermocellum,

B7NIF6, Q0TKG7,

Clostridium phytofermentans,

B7UKF4, B7MQI9,

Clostridium cellulolyticum,

B1IZC0, B6I0Q6,

Edwardsiella ictaluri, Enterobacter

A7ZIN4, P69441,

sp., Escherichia coli, Escherichia coli,
B7LV13, P69442,

Escherichia coli, Escherichia coli,

B1LJN2, A7ZXD2,

Escherichia coli, Escherichia coli,

B1XFR1, B7N927,

Escherichia coli, Escherichia coli,

B7L799, C4ZUS8,

Escherichia coli, Escherichia

B7M3W6, B7MDZ6,

fergusonii, Escherichia coli,

Q4QNJ1, A5UAD6,

Escherichia coli, Escherichia coli,

P24323, A5UGF8,

Escherichia coli, Escherichia coli,

Q7VMY0, Q0I2Y5,

Escherichia coli, Escherichia coli,

A6T5N7, B5Y0N3,

Escherichia coli, Escherichia coli,

Q927M8, C1KZF9,

Haemophilus influenzae,

Q71WG7, A0ALU7,

Haemophilus influenzae,

Q8Y449, B8DB29,

Haemophilus influenzae,

E6MY99, P0A0U7,

Haemophilus influenzae,

A1KT73, P0A0U6,

Haemophilus ducreyi, Haemophilus

P0DH56, A9M3Q2,

somnus, Klebsiella pneumoniae,

Q5F9J3, B4RKA2,

Klebsiella pneumoniae, Listeria

P49979, P49981,

innocua, Listeria monocytogenes,

B4F1Q2, A4XXP5,

Listeria monocytogenes, Listeria

B1JD29, B0KS64,

welshimeri, Listeria monocytogenes,

Q4KHK4, Q9HXV4,

Listeria monocytogenes, Neisseria

Q02RF8, B7V109,

meningitidis, Neisseria meningitidis,

A6V1A1, C3KEC6,

Neisseria meningitidis, Neisseria

A5W880, P0A137,

meningitidis, Neisseria meningitidis,

P0A136, Q886R8,

Neisseria meningitidis, Neisseria

Q3KHE3, Q1IDV1,

gonorrhoeae, Neisseria gonorrhoeae,

Q48F36, Q4ZWV2,

Neisseria gonorrhoeae, Neisseria

B2UB85, Q8XWE1,

mucosa, Proteus mirabilis,

Q8CRI0, Q5HM20,

Pseudomonas mendocina,

Q6G792, P99062,

Pseudomonas putida, Pseudomonas

P65201, Q5HDX9,

putida, Pseudomonas fluorescens,

Q6GEK4, P65202,

Pseudomonas aeruginosa,

A4VYR4, A4VSH4

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas entomophila,

Pseudomonas savastanoi,

Pseudomonas syringae, Ralstonia

pickettii, Ralstonia solanacearum,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus suis, Streptococcus

suis

1491
PGCDHAGIATQ

Fusobacterium nucleatum

Q8RHK3
P26640

1492
PGDGIGPEI

Bacillus clausii, Desulfovibrio vulgaris,

Q5WEN4, Q726X1,
P50213

Pseudomonas aeruginosa,

Q51375, Q88LE5,

Pseudomonas putida, Pseudomonas

Q3KF21, Q4KF05,

fluorescens, Pseudomonas

Q48K97, Q4ZUZ4,

fluorescens, Pseudomonas

Q884C0, Q4L7U1,

savastanoi, Pseudomonas syringae,

Q49Z13, Q5HMF8,

Pseudomonas syringae,

Q8CNL2, Q2FWK2,

Staphylococcus haemolyticus,

Q6GF15, Q6G7Q0,

Staphylococcus saprophyticus,

P65101, P65100,

Staphylococcus epidermidis,

Q2YUF1, Q5HEE3,

Staphylococcus epidermidis,

Q2FF66, Q8NVJ0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1493
PGLAHFLEH

Pseudomonas syringae,

Q88A79, P55174,
O43847

Pseudomonas protegens,

Q9I2D2, Q88QV3

Pseudomonas aeruginosa,

Pseudomonas putida

1494
PGLGKTTLA

Desulfovibrio alaskensis,

Q30YX7, P61531,
Q8WVB6

Desulfovibrio vulgaris, Desulfovibrio

A1VC44

vulgaris

1495
PGMVLTVEPG

Escherichia coli, Streptomyces

P15034, P0A3Z2,
P12955

lividans, Streptomyces coelicolor

P0A3Z1

1496
PGRVNLIGEH

Clostridium tetani

Q896X8
P51570

1497
PGRVNLIGEHTDY

Fusobacterium nucleatum,

Q8RHD0, Q97EZ6,
P51570

N

Clostridium acetobutylicum,

A6M1P8

Clostridium beijerinckii

1498
PGSGKGTQS

Parabacteroides distasonis

A6LD69
Q9Y6K8

1499
PGSSIMPGKVNP

Bacillus subtilis, Helicobacter pylori,

P26899, Q9ZLI5,
P07954

Helicobacter pylori, Pseudomonas

P56149, P07346,

fluorescens, Pseudomonas

Q51404, Q9HTD7,

aeruginosa, Pseudomonas

Q9FBN6, Q82ID7

aeruginosa, Streptomyces coelicolor,

Streptomyces avermitilis

1500
PGTGKTLLA

Akkermansia muciniphila

B2UMY1
Q9Y4W6

1501
PGTGKTLLAKA

Ralstonia pickettii, Uncultured termite
B2UE66, B1GZK7
Q9Y4W6

1502
PGVGQNLQDH

Rhizobium meliloti

P54223
Q8NE62

1503
PGYTHLQRAQ

Clostridium kluyveri, Clostridium

B9E0B2, A5N6U3,
P04424

kluyveri, Clostridium tetani,

P59616, Q182I5

ptoclostridium difficile

1504
PGYTHLQRAQPI

Bacillus licheniformis

Q65G68
P04424

1505
PHGLGHFLG

Aeromonas salmonicida, Aeromonas

A4STF0, A0KEL3
P12955

hydrophila

1506
PHLGASTKEAQ

Bacillus subtilis

P35136
O43175

1507
PHVNVGTIGHVDH

Pseudomonas fluorescens,

C3K2X8, Q4ZMP2,
P49411

G

Pseudomonas syringae,

Q48D34, Q3K5X4,

Pseudomonas savastanoi,

B1JDW6, B0KK53,

Pseudomonas fluorescens,

A5VXN3, Q88QP8,

Pseudomonas putida, Pseudomonas

Q1IFW8, Q88QN7

putida, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas putida

1508
PIFHVNADD

Staphylococcus aureus,

Q931R8, A5ISU5,
Q9ULD0

Staphylococcus aureus,

A7X295, A6U1N4,

Staphylococcus aureus,

Q8NWR6, Q5HG06,

Staphylococcus aureus,

A8Z3Z0, Q2FH25,

Staphylococcus aureus,

Q2FYM1, Q6G9E8,

Staphylococcus aureus,

A6QGW6, Q6GGZ5,

Staphylococcus aureus,

P0C601, Q99U74,

Staphylococcus aureus,

Q2YY05

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1509
PIGRGQREL

Desulfovibrio alaskensis

Q313V8
P25705

1510
PIGRGQRELIIGDR

Bacillus clausii, Clostridium kluyveri,

Q5WB76, B9DX63,
P25705

QTGKT

Clostridium kluyveri, Clostridium

A5N3H9, A6LQH4,

beijerinckii, Desulfovibrio vulgaris,

B8DRD0, B8J437,

Desulfovibrio desulfuricans,

C4XI08

Desulfovibrio maeticus

1511
PIGRGQRELIIGDR

Parabacteroides distasonis,

A6L8N5, Q64UA4,
P25705

QTGKTSIAIDTIINQ

Bacteroides fragilis, Bacteroides

Q5LD82, Q8A9U7

fragilis, Bacteroides thetaiotaomicron

1512
PIIMVGPGTG

Bacillus subtilis, Bacillus subtilis

O32214, O08394
Q9UBK8

1513
PILTMPNDDITHPI

Clostridium tetani

Q891P2
P15313

PDLTG

1514
PISAKLVAN

Rhizobium meliloti

Q92N73
P11908

1515
PISAKLVANM

Rhizobium loti

Q98HW3
P11908

1516
PISAKLVANML

Neisseria meningitidis, Neisseria

P65235, P65234
P11908

meningitidis

1517
PIWEQTGRGER

Geobacter metallireducens,

Q39UH2, Q74C82,
Q16740

Geobacter sulfurreducens, Geobacter

B5EI27, B9M0Y1,

bemidjiensis, Geobacter daltonii,

A5GFA0, C6E2T0

Geobacter uraniireducens, Geobacter

sp.

1518
PIVYTPTVG

Bacillus subtilis

O34389
P48163

1519
PKDKPRYLMGVG

Staphylococcus carnosus,

B9DNG7, Q2YT91,
Q9BXR0

Staphylococcus aureus,

A8Z2G7, P66906,

Staphylococcus aureus,

Q6G8T0, P66905,

Staphylococcus aureus,

A60HI1, Q6GG65,

Staphylococcus aureus,

P66904, A5ITG3,

Staphylococcus aureus,

Q5HFC4, Q2FXT6,

Staphylococcus aureus,

Q2FG88, A7X354,

Staphylococcus aureus,

A6U2A7, Q5HNR2,

Staphylococcus aureus,

Q8CML7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1520
PKGFGGVQVSPP

Aeromonas hydrophila

P41131
P04746

1521
PKGVLLYGPPG

Bifidobacterium animalis,

C6A7B2, C6AHX0,
Q8NBU5

Bifidobacterium animalis,

B8DTX4, D3R4I7

Bifidobacterium animalis,

Bifidobacterium animalis

1522
PKILLLDEP

Bacillus cereus, Bacillus cereus,

O31339, Q81GU1,
Q8WWZ7

Pseudomonas aeruginosa

Q9I6L0

1523
PLFILYTSGSTGKP

Ralstonia pickettii, Ralstonia

B2U6V1, Q8XY11
Q9NR19

KGV

solanacearum

1524
PLGVCVGIGAWN

Rhizobium leguminosarum

Q1MJU3
P49189

YP

1525
PLHVCEQRD

Bacillus subtilis

O06735
O43252

1526
PLIGFAGAP

Streptomyces griseus, Streptomyces

B1WVH6, Q82KY4,
P06132

avermitilis, Streptomyces coelicolor

Q69861

1527
PLKGARIAG

Corynebacterium glutamicum,

A4QQ87, Q8NSC4,
P23526

Corynebacterium glutamicum,

Q8FRJ4, Q8Y387,

Corynebacterium efficiens, Ralstonia

B2U774

solanacearum, Ralstonia pickettii

1528
PLRGKILNV

Bacillus subtilis, Bacillus halodurans,

P05652, O50627,
P11388

Campylobacter jejuni, Staphylococcus

O87667, P0A0K7,

aureus, Staphylococcus aureus,

P0A0K8, Q6GD85,

Staphylococcus aureus,

Q2FKQ1, P66937,

Staphylococcus aureus,

P66936, Q8CQK4,

Staphylococcus aureus,

Q5HK03, Q6GKU0,

Staphylococcus aureus,

Q5HJZ1

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus aureus,

Staphylococcus aureus

1529
PLSVELGPG

Clostridium novyi, Clostridium

A0PZC6, B1IJM8,
P38606

botulinum, Clostridium botulinum,

A7GGL4, B1KXT6,

Clostridium botulinum, Clostridium

A51557, A7FWQ7,

botulinum, Clostridium botulinum,

A3DHP0

Clostridium thermocellum

1530
PLTGRTHQIR

Helicobacter pylori, Helicobacter

Q9ZMA1, QO5114
Q8IZ73

pylori

1531
PLTLGGDHTIT

Pseudomonas aeruginosa

Q9I3S3
Q9BSE5

1532
PLVVRLEGTNV

Bacillus pumilus, Bacillus

A8FD73, Q65JP0,
Q96199

licheniformis, Bacillus

A7Z4M9, P80886

methylotrophicus, Bacillus subtilis

1533
PMGWDAFGLPAE

Bacillus licheniformis, Bacillus subtilis,

Q65FX8, P36430,
Q15031

Bacillus halodurans, Haemophilus

Q9K758, Q7VM66,

ducreyi, Streptococcus pneumoniae,

B2IS10, C1CPD0,

Streptococcus pneumoniae,

B1I8Y2, C1CID7,

Streptococcus pneumoniae,

A4VY58, A4W4F3,

Streptococcus pneumoniae,

C1CC47, Q97SS0,

Streptococcus suis, Streptococcus

B8ZKS5, Q03MJ2,

suis, Streptococcus pneumoniae,

Q5M657, Q5M1L6,

Streptococcus pneumoniae,

B5E6T0, Q8DRB6,

Streptococcus pneumoniae,

Q04MJ2, C1CB31,

Streptococcus thermophilus,

P67515, P67514,

Streptococcus thermophilus,

Q3JYR6, A3CKP1,

Streptococcus thermophilus,

A8AZ43, B4U0A1,

Streptococcus pneumoniae,

C0M8N3, Q8P2T2,

Streptococcus pneumoniae,

Q1JNR2, Q1JDV2,

Streptococcus pneumoniae,

Q1JIV9, Q8DS85,

Streptococcus pneumoniae,

Q5XE35, C0MET9,

Streptococcus agalactiae,

P0DG45, P0DG44,

Streptococcus agalactiae,

A2RCB2, Q9A1P0,

Streptococcus agalactiae,

B5XJI9, Q48VJ7,

Streptococcus sanguinis,

Q1J8Q8

Streptococcus gordonii,

Streptococcus equi, Streptococcus

equi, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans, Streptococcus

pyogenes, Streptococcus equi,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

1534
PMGWDAFGLPAE

Clostridium thermocellum,

A3DEU0, A1VEL2,
Q15031

NAA

Desulfovibrio vulgaris, Desulfovibrio

Q72CT7, Q30YL0,

vulgaris, Desulfovibrio alaskensis,

B8DJF0, B2FPR7,

Desulfovibrio vulgaris,

B4SRE7

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1535
PNVGKSSFI

Geobacter sulfurreducens, Geobacter

Q74702, Q39QR4
Q9BZE4

metallireducens

1536
PNVGKSSIIN

Clostridium phytofermentans,

A9KLK7, C4Z0C8
Q9BVP2

Eubacterium eligens

1537
PNVGKSSLIN

Eubacterium rectale, Clostridium

C4ZD63, Q895X8,
Q9NVN8

tetani, Clostridium botulinum,

B2THQ9, Q0SS66,

Clostridium perfringens, Clostridium

Q8XJK1, Q0TPJ9,

perfringens, Clostridium perfringens,

B2V3Z1, A5N7W7,

Clostridium botulinum, Clostridium

B9E1C8, A6LSI6,

kluyveri, Clostridium kluyveri,

A5I4V0, A7FW89,

Clostridium beijerinckii, Clostridium

A3DE77, A0Q125,

botulinum, Clostridium botulinum,

B1KX71, B1IIN2,

Clostridium thermocellum, Clostridium

C1FSU2, A7GGA7,

novyi, Clostridium botulinum,

C3L0M1, Q834T4,

Clostridium botulinum, Clostridium

B051N2, Q9ZLF3,

botulinum, Clostridium botulinum,

O25396, B9DTQ3

Clostridium botulinum, Enterococcus

faecalis, Finegoldia magna,

Helicobacter pylori, Helicobacter

pylori, Streptococcus uberis

1538
PNVTDIVSIARAA

Desulfovibrio maeticus

C4XPD6
Q12882

1539
PPKGVLLYGPPG

Bifidobacterium dentium,

D2Q9C6, A1A0U4,
Q8NBU5

Bifidobacterium adolescentis,

B7GUP3, B3DRN4,

Bifidobacterium longum,

Q8G3G6, Q4JVP5,

Bifidobacterium longum,

B1VDV2

Bifidobacterium longum,

Corynebacterium jeikeium,

Corynebacterium urealyticum

1540
PPKGVLLYGPPGC

Corynebacterium glutamicum,

Q8NQD8, A4QE83,
Q8NBU5

GKTLIAKA

Corynebacterium glutamicum,

Q8FTE3, Q6NH92,

Corynebacterium efficiens,

C9Z319, Q828J2,

Corynebacterium diphtheriae,

Q9RJ58

Streptomyces scabiei, Streptomyces

avermitilis, Streptomyces coelicolor

1541
PPPNVTGSLH

Sphingomonas elodea

Q7X2N3
P26640

1542
PQDATTNPSLIL

Haemophilus somnus, Haemophilus

Q01IU0, A5UIP9,
P37837

influenzae, Haemophilus influenzae,

P45055, A5UCY0,

Haemophilus influenzae,

Q4QLG9, Q7VP02

Haemophilus influenzae,

Haemophilus ducreyi

1543
PQGTLAERIRAGG

Bacillus subtilis, Haemophilus

O34317, P44875
P55809

AG

influenzae

1544
PQILLLDEP

Escherichia coli, Escherichia coli,

Q8FFB3, Q8XBJ8,
Q8N139

Escherichia coli

P16676

1545
PQNRVTDHRI

Lactobacillus helveticus, Lactobacillus

A8YUJ1, Q042K5,
Q9UGC7

gasseri, Lactobacillus acidophilus,

Q5FKZ0, Q74K25,

Lactobacillus johnsonii, Lactobacillus

B2GAT1, Q1GAX5,

fermentum, Lactobacillus delbrueckii,

Q04BB3, Q03QX7,

Lactobacillus delbrueckii,

Q8Y4A8, B8DBG6,

Lactobacillus brevis, Listeria

Q71WN5, C1KYW0,

monocytogenes, Listeria

A0ALM8, Q927V0

monocytogenes, Listeria

monocytogenes, Listeria

monocytogenes, Listeria welshimeri,

Listeria innocua

1546
PRFRGEHALRRY

Methylobacterium extorquens,

A9W1M5, B1LUM8,
O00217

P

Methylobacterium radiotolerans,

B7KQ58, B1ZA38

Methylobacterium extorquens,

Methylobacterium populi

1547
PRNLAKSVTVE

Bacillus halodurans, Staphylococcus

Q9KG45, Q8CRL1,
Q06210

epidermidis, Staphylococcus

Q5HM69, Q97SQ9,

epidermidis, Streptococcus

Q8DRA8, Q86781

pneumoniae, Streptococcus

pneumoniae, Streptomyces coelicolor

1548
PSAFDRILASR

Clostridium novyi

A0PYC8
Q01813

1549
PSGAGKSTL

Ralstonia solanacearum

Q8XXF9
Q16774

1550
PTGGGKSLCYQL

Bacillus subtilis

P50729
P54132

P

1551
PTQGMRQGND

Pseudomonas savastanoi,

Q48CJ2, A4XPS6,
Q9UJ68

Pseudomonas mendocina,

Q88AI5, B0KJ25,

Pseudomonas syringae,

Q1I3L0, Q88QZ8,

Pseudomonas putida, Pseudomonas

B1JE82

entomophila, Pseudomonas putida,

Pseudomonas putida

1552
PVDIYIPGC

Campylobacter concisus

A7ZBE5
O75251

1553
PVDLFPHTPH

Desulfovibrio vulgaris

Q72DK5
Q96GJ1

1554
PVFGICLGHQLLA

Pseudomonas stutzeri

P38099
P27708

LA

1555
PVFNTVKEA

Methylobacterium extorquens

P53595
P53597

1556
PVLGICYGM

Ralstonia solanacearum

Q8XZG4
P49915

1557
PVLGICYGMQ

Bacillus methylotrophicus, Bacillus

A7Z235, P29727,
P49915

subtilis, Bacillus licheniformis, Bacillus

Q65MU0, A8FAH5,

pumilus, Campylobacter jejuni,

A1W0N3, A7H2D2,

Campylobacter jejuni, Campylobacter

Q9PN49, A0RQD7,

jejuni, Campylobacter fetus,

B9KFL4, B8I4P0,

Campylobacter lari, Clostridium

C6BSD8, A1VEV0,

cellulolyticum, Desulfovibrio

Q72D86, Q31IX7,

salexigens, Desulfovibrio vulgaris,

B9M9G4, Q39TA7,

Desulfovibrio vulgaris, Desulfovibrio

P60500, P44335,

alaskensis, Geobacter daltonii,

Q0I2D2, Q4QNW4,

Geobacter metallireducens,

Q7VLE9, B8F3T2,

Geobacter sulfurreducens,

Q9JXR2, Q5F4X9,

Haemophilus influenzae,

B4RJH7, A9M138,

Haemophilus somnus, Haemophilus

B4EY59, B0KRE6,

influenzae, Haemophilus ducreyi,

Q88P21, A5VZC3,

Haemophilus parasuis, Neisseria

Q1I5K9, A4XY17,

meningitidis, Neisseria gonorrhoeae,

Q8CMQ8, Q4L386,

Neisseria gonorrhoeae, Neisseria

Q5HRX1, Q2YVL5,

meningitidis, Proteus mirabilis,

Q8NY69, Q6GC81,

Pseudomonas putida, Pseudomonas

P64296, A5IPX0,

putida, Pseudomonas putida,

Q6GJQ6, A7WY93,

Pseudomonas entomophila,

P99105, A6TYP2,

Pseudomonas mendocina,

B9DLM7, A6QE71,

Staphylococcus epidermidis,

A8Z0R1, Q5HIQ6,

Staphylococcus haemolyticus,

Q2G0Y6, Q2FJM5,

Staphylococcus epidermidis,

Q8DU81

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus carnosus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus mutans

1558
PVTLELGGKSP

Acinetobacter sp., Escherichia coli,
Q9FDS1, P37685,
P51648

Pseudomonas sp., Streptomyces
O86447, F8JX40,

cattleya, Streptomyces coelicolor

Q9RJZ6

1559
PVVAMVWEG

Desulfitobacterium hafniense,

Q251Q1, B8FZD1
O60361

Desulfitobacterium hafniense

1560
PVVTIMGHVDHGK

Acinetobacter baumannii,

B0VLU2, B0VE81,
P46199

T

Acinetobacter baumannii,

B2I2M7, B7I3R9,

Acinetobacter baumannii,

B7H115, Q6FF40,

Acinetobacter baumannii,

A0KNE3, A4SJR5,

Acinetobacter baumannii,

B1ZDQ8, Q30WJ0,

Acinetobacter baylyi, Aeromonas

A1VG83, Q72ER1,

hydrophila, Aeromonas salmonicida,

B8J1Y4, C5BFB7,

Methylobacterium populi,

Q9ZF25, A5GF86,

Desulfovibrio alaskensis,

Q74CT3, B5EI57,

Desulfovibrio vulgaris, Desulfovibrio

B3EAE7, C6E2Q0,

vulgaris, Desulfovibrio desulfuricans,

Q39VA6, B9M1G0,

Edwardsiella ictaluri, Enterobacter

Q4QK37, A5UF34,

cloacae, Geobacter uraniireducens,

P44323, A5UBT6,

Geobacter sulfurreducens, Geobacter

Q0I3P5, Q7VLI2,

bemidjiensis, Geobacter lovleyi,

Q9ZF28, B5XSX4,

Geobacter sp., Geobacter
A6TEI7, Q2KDZ5,

metallireducens, Geobacter daltonii,

Q1MN39, B3PXE3,

Haemophilus influenzae,

Q981318, A5VCZ5,

Haemophilus influenzae,

B2FN90, B4SQS0

Haemophilus influenzae,

Haemophilus influenzae,

Haemophilus somnus, Haemophilus

ducreyi, Klebsiella oxytoca, Klebsiella

pneumoniae, Klebsiella pneumoniae,

Rhizobium etli, Rhizobium

leguminosarum, Rhizobium etli,

Rhizobium loti, Sphingomonas

wittichii, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

1561
PVVTIMGHVDHG

Bacillus halodurans, Bacillus

Q9KA77, A7Z4T4,
P46199

KTTLLD

methylotrophicus, Bacillus subtilis,

P17889, A8YVQ7,

Lactobacillus helveticus, Bacillus

A8FDD1, Q65JI1,

pumilus, Bacillus licheniformis,

Q5FJN6, Q5WFU2,

Lactobacillus acidophilus, Bacillus

Q38W81, Q049V5,

clausii, Lactobacillus sakei,

Q1G9P9, Q04467,

Lactobacillus delbrueckii,

Q74IS8, Q835U8,

Lactobacillus delbrueckii,

P18311, B1MZH4,

Lactobacillus gasseri, Lactobacillus

B8DG02, A0AIC6,

johnsonii, Enterococcus faecalis,

Q92C29, Q71ZZ7,

Enterococcus faecium, Leuconostoc

C1L2N1, Q8Y7F6,

citreum, Listeria monocytogenes,

B8ZM93, B5E266,

Listeria welshimeri, Listeria innocua,

B2IME4, C1CCT8,

Listeria monocytogenes, Listeria

Q8DQV2, Q04LW0,

monocytogenes, Listeria

C1CQ48, C1C5S8,

monocytogenes, Streptococcus

C1CJ39, Q97S57,

pneumoniae, Streptococcus

B1IA80

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae

1562
PVVTIMGHVDHG

Lactobacillus salivarius

Q1WUF4
P46199

KTTLLDK

1563
PWGKGRPGWHIE

Lactobacillus reuteri, Lactobacillus

B2G555, A5VI99,
P49589

CS

reuteri, Lactobacillus casei,

Q035S0, B3WA35,

Lactobacillus casei, Lactobacillus

Q38UZ6, Q045X8,

sakei, Lactobacillus gasseri,

A8YTD3, Q74L26,

Lactobacillus helveticus, Lactobacillus

Q5FM34, Q048S9,

johnsonii, Lactobacillus acidophilus,

Q1G8Z0, Q97ED6,

Lactobacillus delbrueckii,

Q839V5, B1MW68,

Lactobacillus delbrueckii, Clostridium

A4XVG1, Q8E7F2,

acetobutylicum, Enterococcus

Q8E1Z4, Q3K3G5

faecalis, Leuconostoc citreum,

Pseudomonas mendocina,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae

1564
PWGKGRPGWHIE

Bacillus subtilis, Bacillus

Q06752, A7Z0L6,
P49589

CSAM

methylotrophicus, Bacillus

Q9KGF4, B8G1U2,

halodurans, Desulfitobacterium

Q250Q6, A5G949,

hafniense, Desulfitobacterium

B3E1P0, B9LZV4,

hafniense, Geobacter uraniireducens,

B8F392, B1GYT2

Geobacter lovleyi, Geobacter daltonii,

Haemophilus parasuis, Uncultured

termite

1565
PWGKGRPGWHIE

Bacillus cytotoxicus, Bacillus

A7GK01, A9VNA2,
P49589

CSAMA

weihenstephanensis, Bacillus

Q65PC8, A3DH43

licheniformis, Clostridium

thermocellum

1566
PWTIPANEA

Lactobacillus helveticus, Lactobacillus

A8YUP7, Q5FKU5
Q9NSE4

acidophilus

1567
PWTIRQYAGFST

Escherichia coli, Streptomyces

P27253, Q05065
P22033

cinnamonensis

1568
PWVRNIFIVT

Neisseria meningitidis

Q51151
Q3T906

1569
PYPSGKLHMGHV

Ralstonia solanacearum, Ralstonia

Q8XVT3, B2UCA1
Q15031

R

pickettii

1570
PYVSGFLAFRE

Bacillus methylotrophicus, Bacillus

A7Z9I5, P96724
Q8N8Q3

subtilis

1571
QAHGLCFSV

Bacteroides vulgatus, Bacteroides

A6L7T5, Q64PM3,
P13051

fragilis, Bacteroides fragilis,

Q5L9D9, Q8A5V6

Bacteroides thetaiotaomicron

1572
QAHGLCFSVQ

Pseudomonas aeruginosa,

B7UYZ2, A6VAM7,
P13051

Pseudomonas aeruginosa,

Q9I5H9, Q02HQ1

Pseudomonas aeruginosa,

Pseudomonas aeruginosa

1573
QCGTIQLDF

Haemophilus parasuis

B8F5H9
Q9BW92

1574
QDDAHIFCT

Acinetobacter baumannii,

B2HTH0, B7H005,
A2RTX5

Acinetobacter baumannii,

B0V5P2, A3M299,

Acinetobacter baumannii,

B7I688, A0KKP9,

Acinetobacter baumannii,

A4SMA4, C5B846,

Acinetobacter baumannii, Aeromonas

A4W9M3, Q1RB76,

hydrophila, Aeromonas salmonicida,

B1LE12, B7N556,

Edwardsiella ictaluri, Enterobacter

P0A8M3, P0A8M4,

sp., Escherichia coli, Escherichia coli,
Q0THB0, A1ABQ2,

Escherichia coli, Escherichia coli,

B1XGI1, C4ZYI1,

Escherichia coli, Escherichia coli,

B7MVJ7, B7NT58,

Escherichia coli, Escherichia coli,

B7MAS9, B7USA2,

Escherichia coli, Escherichia coli,

B7LQ71, B5YQ07,

Escherichia coli, Escherichia coli,

Q8XE27, B7M1C7,

Escherichia coli, Escherichia

B6IBD7, B1IPK9,

fergusonii, Escherichia coli,

A8A0R2, B7L6J2,

Escherichia coli, Escherichia coli,

A7ZMI6, Q7VKR9,

Escherichia coli, Escherichia coli,

Q0I3M2, A5UBX5,

Escherichia coli, Escherichia coli,

Q4QK77, P43014,

Escherichia coli, Haemophilus

A5UEK1, B5XQC6,

ducreyi, Haemophilus somnus,

Q5F9U4, Q9K095,

Haemophilus influenzae,

A9M375, Q9JVA3,

Haemophilus influenzae,

B4ETK6, Q48JS3,

Haemophilus influenzae,

Q4ZUG7, Q883H9,

Haemophilus influenzae, Klebsiella

A6V485, B7V188,

pneumoniae, Neisseria gonorrhoeae,

Q9I099, Q02NP1,

Neisseria meningitidis, Neisseria

Q3KEY2, A4VM22,

meningitidis, Neisseria meningitidis,

B1J6U4, A4XTS1,

Proteus mirabilis, Pseudomonas

C3JZN7, Q88K27,

savastanoi, Pseudomonas syringae,

B0KKR8, A5W5E1,

Pseudomonas syringae,

Q1IC15, Q8XZ29,

Pseudomonas aeruginosa,

Q1MGA7

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas stutzeri, Pseudomonas

putida, Pseudomonas mendocina,

Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas entomophila, Ralstonia

solanacearum, Rhizobium

leguminosarum

1575
QDFTGVPAVVD

Escherichia coli, Pseudomonas

P25516, Q9I3F5
P21399

aeruginosa

1576
QDPLAELVKI

Escherichia coli

P46837
Q8N5C6

1577
QDPLAELVKIEPK

Haemophilus influenzae

P71353
Q8N5C6

1578
QEEIFGPVL

Staphylococcus aureus,

Q7A1Y7, Q7A825,
P30838

Staphylococcus aureus,

Q99X54, Q6GCV9,

Staphylococcus aureus,

Q2G1J0, Q5HJK3,

Staphylococcus aureus,

Q2FK94, Q6GKD8,

Staphylococcus aureus,

Q2YV11

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1579
QGARLTAFEL

Clostridium phytofermentans,

A9KIE9, A1VHH2,
Q9BV20

Desulfovibrio vulgaris, Desulfovibrio

Q72FX9

vulgaris

1580
QGFFDIPVDNL

Enterococcus faecalis, Streptococcus

Q832Z5, Q99ZR0,
P11908

pyogenes, Streptococcus pyogenes,

Q5XC85, P0DCQ0,

Streptococcus pyogenes,

P0DC01, Q8P137,

Streptococcus pyogenes,

Q8E568, Q8DZK4,

Streptococcus pyogenes,

P65241, P65242,

Streptococcus agalactiae,

Q8DU94

Streptococcus agalactiae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus mutans

1581
QGMNAAVRAVVR

Paenibacillus macquariensis

Q59214
Q01813

1582
QGMRQGNDH

Escherichia coli

Q0T9G6
Q9UJ68

1583
QGMRQGNDHGT

Escherichia coli, Escherichia

B1LRA3, B7LMP0,
Q9UJ68

QYRSAIYP

fergusonii, Escherichia coli,

B7NGF6, B7NUD2,

Escherichia coli, Escherichia coli,

B7MTA1, B7UQN3,

Escherichia coli, Escherichia coli,

P0A744, B1ISY2,

Escherichia coli, Escherichia coli,

A8A7X5, B1XDW8,

Escherichia coli, Escherichia coli,

C4ZR95, B7M9I1,

Escherichia coli, Escherichia coli,

B7LCT1, B7MLN1,

Escherichia coli, Escherichia coli,

A7ZV98, B5Z3H5,

Escherichia coli, Escherichia coli,

Q8XCG3, Q8FAG4,

Escherichia coli, Klebsiella

B5Y2Y3

pneumoniae

1584
QGNDHGTQYRSA

Enterobacter sp.
A4W5V5
Q9UJ68

IYP

1585
QGVLLLNAVLTV

Leuconostoc mesenteroides

Q03W63
P13051

1586
QGVLLLNAVLTVR

Streptomyces avermitilis

Q827B3
P13051

1587
QGVLLLNAVLTVR

Streptomyces coelicolor

Q9K3Z0
P13051

A

1588
QHLFWFFGHPEV

Corynebacterium diphtheriae,

Q6NFM3, Q8FMT1,
P00395

Y

Corynebacterium efficiens,

Q79VD7

Corynebacterium glutamicum

1589
QHLFWFFGHPEV

Streptomyces avermitilis,

Q82AK9, Q828X4,
P00395

Y1

Streptomyces avermitilis,

Q9X813, Q9K451

Streptomyces coelicolor,

Streptomyces coelicolor

1590
QILTEPRNA

Streptococcus pyogenes,

P0DA37, Q48U22,
O76031

Streptococcus pyogenes,

Q1J741, Q1JHC2,

Streptococcus pyogenes,

P63795, P0DA36,

Streptococcus pyogenes,

P63793

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

1591
QIQGFFDIP

Bacillus subtilis, Bacillus caldolyticus,

P14193, P42816,
P11908

Bacillus cereus, Bacillus anthracis,

Q81J97, Q81VZ0,

Fusobacterium nucleatum,

Q8RHM2, O33924,

Corynebacterium ammoniagenes,

Q4L3F7, Q8CQU7,

Staphylococcus haemolyticus,

Q5HRQ5, Q5HIH5,

Staphylococcus epidermidis,

Q6GJH1, P65237,

Staphylococcus epidermidis,

P65238, Q6GBY8,

Staphylococcus aureus,

P65236

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1592
QIQGFFDIPVD

Bacillus halodurans, Lactobacillus

Q9KGJ5, Q88VA5,
P11908

plantarum, Clostridium

Q97E93, P0DB99,

acetobutylicum, Streptococcus

P65245, Q5XEL0,

pyogenes, Streptococcus pyogenes,

P0DB98, P65243,

Streptococcus pyogenes,

P65240, P65239,

Streptococcus pyogenes,

Q8E2H0, Q8E7X8,

Streptococcus pyogenes,

Q8DWM2

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus mutans

1593
QIQGFFDIPVDN

Pseudomonas aeruginosa, Ralstonia

Q9HVC5, Q8Y2E1
P11908

solanacearum

1594
QIQGFFDIPVDNLY

Helicobacter hepaticus

Q7VFY9
P11908

1595
QIQNALGSDI

Listeria innocua, Listeria welshimeri,

Q92B14, A0AIX9,
Q9BXR0

Listeria monocytogenes, Listeria

B8DHL8, Q8Y700,

monocytogenes, Listeria

Q71ZE0, C1KVH7

monocytogenes, Listeria

monocytogenes

1596
Q1YRIDHYLGKE

Aggregatibacter

P77809
P11413

actinomycetemcomitans

1597
QKEVAERLAA

Lactobacillus delbrueckii,

Q04C60, Q1GBR1,
Q8WVM0

Lactobacillus delbrueckii,

A6LF39

Parabacteroides distasonis

1598
QKEVAERLAAN

Lactobacillus salivarius

Q1WV73
Q8WVM0

1599
QKGTGRARH

Rhizobium loti, Rhizobium

Q98N56, B5ZYT6,
Q9BYD3

leguminosarum, Rhizobium etli,

Q2K9L5, Q1MIE0,

Rhizobium leguminosarum,

B3PWS2, Q92QG9,

Rhizobium etli, Rhizobium meliloti,

C3MAY1

Rhizobium sp.

1600
QLDTPERGFS

Clostridium novyi, Clostridium

A0Q055, A9KM86
A6NJ78

phytofermentans

1601
QLKGAGPTPFSR

Rhizobium leguminosarum,

B5ZUP2, B3PTN1,
Q9BVL4

Rhizobium etli, Rhizobium

Q1MJK8

leguminosarum

1602
QLKQFTTVVADTG

Pseudomonas stutzeri, Pseudomonas

A4VK43, Q88KX1,
P37837

D

putida, Pseudomonas putida,

B1J623, B0KHA7,

Pseudomonas putida, Pseudomonas

Q1I7G7, A4XTM7

entomophila, Pseudomonas

mendocina

1603
QLKQFTTVVADTG

Pseudomonas fluorescens

Q3K9H0
P37837

DF

1604
QLSGGQKQR

Bacillus subtilis, Bacillus anthracis,

O34900, Q81ZF5,
Q2M3G0

Bacillus cereus, Bacillus thuringiensis,

Q81IN8, Q6HP89,

Bacillus halodurans, Bifidobacterium

Q9K789, Q8G5P8,

longum, Corynebacterium

Q8N5N2, Q4JTG9,

glutamicum, Corynebacterium

Q8FRX8, Q831K6,

jeikeium, Corynebacterium efficiens,

Q92EZ6, Q724C0,

Enterococcus faecalis, Listeria

Q8YA75, Q6A6X6

innocua, Listeria monocytogenes,

Listeria monocytogenes,

Propionibacterium acnes

1605
QLSGGQKQRV

Bacillus licheniformis, Bacillus clausii,

Q65F80, Q5WDP1,
Q9NP78

Bacillus cereus, Bacillus subtilis,

Q73EL7, O32169,

Bacillus cereus, Fusobacterium

Q63GR8, Q8RFN2,

nucleatum, Desulfitobacterium

Q240I5

hafniense

1606
QLSGGQKQRVA

Leuconostoc mesenteroides,

Q03Z27, Q03EE4
Q9NP78

Pediococcus ntosaceus

1607
QLYQRSGDM

Lactobacillus gasseri, Lactobacillus

Q044A1, Q5FKL6,
P04818

acidophilus, Lactobacillus delbrueckii,

Q041329, Q1GAP2,

Lactobacillus delbrueckii,

Q74IU3

Lactobacillus johnsonii

1608
QMQYNLRLR

Ralstonia solanacearum

Q8Y270
Q6PI48

1609
QPPKGVLLYGPP

Corynebacterium aurimucosum,

C3PGA0, C4LIL2
Q8NBU5

GCGKTLIAKA

Corynebacterium kropnstedtii

1610
QREDDKPETV

Streptococcus mutans, Streptococcus

Q8D533, A3CK85,
Q9UIJ7

sanguinis, Streptococcus

Q5LXT2, Q5M2D4,

thermophilus, Streptococcus

Q03IH2, C1CAN3,

thermophilus, Streptococcus

Q97SU1, B2IS63,

thermophilus, Streptococcus

B5E6H6, C1CPA9,

pneumoniae, Streptococcus

C1CIB8, B1I8L9,

pneumoniae, Streptococcus

C1CC27, Q04ML5,

pneumoniae, Streptococcus

Q8DRD4, B8ZKQ1,

pneumoniae, Streptococcus

C0ME26, C0M6X3,

pneumoniae, Streptococcus

A8AZK4, P69882,

pneumoniae, Streptococcus

Q1J8Z2, P0DB92,

pneumoniae, Streptococcus

P0DB93, P65204,

pneumoniae, Streptococcus

P65203, B9DSX1,

pneumoniae, Streptococcus

Q1JJ40, Q48V58,

pneumoniae, Streptococcus

B5XJ57, Q1JE38,

pneumoniae, Streptococcus equi,

Q1JNZ6, Q8P2Z4,

Streptococcus equi, Streptococcus

Q5XEB4, A2RC35,

gordonii, Streptococcus pyogenes,

Q3K3U8

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus uberis, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae

1611
QRIAIARAL

Escherichia coli, Escherichia coli,

Q47258, Q8FDZ8,
Q9NRK6

Escherichia coli, Escherichia coli,

P10089, P08716,

Escherichia coli, Proteus vulgaris

Q46717, P11599

1612
QRIAIARALV

Clostridium novyi, ptoclostridium

A0PY57, Q18AM3
Q2M3G0

difficile

1613
QRLAIARAL

Haemophilus influenzae,

Q40PI4, Q7VL52,
Q9NUT2

Haemophilus ducreyi, Haemophilus

P44407, Q0I4C5,

influenzae, Haemophilus somnus,

P45082, Q9HUG8,

Haemophilus influenzae,

Q3KJ31, Q88D92,

Pseudomonas aeruginosa,

Q4KJB2, Q48P40,

Pseudomonas fluorescens,

Q4ZZ16, Q87VF3

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas

savastanoi, Pseudomonas syringae,

Pseudomonas syringae

1614
QRQATKDAG

Bacillus clausii, Bacillus halodurans,

Q5WHG1, Q9KD72,
P11021

Lactobacillus acidophilus,

Q84BU4, Q03QU1,

Lactobacillus brevis, Bifidobacterium

A1A3P5, A3DF25,

adolescentis, Clostridium

P30721, B9E041,

thermocellum, Clostridium

A5N6M2, A6LRN4,

acetobutylicum, Clostridium kluyveri,

Q892R0, B1KZN7,

Clostridium kluyveri, Clostridium

A7GHH6, C1FVU0,

beijerinckii, Clostridium tetani,

A5I640, A7FXL5,

Clostridium botulinum, Clostridium

B1ILM3, C3L3G7,

botulinum, Clostridium botulinum,

B1VHX4, Q74H59,

Clostridium botulinum, Clostridium

Q39PT7, B3E7W9,

botulinum, Clostridium botulinum,

B9M357, A5GDC8,

Clostridium botulinum,

C6E643, B5EC42,

Corynebacterium urealyticum,

A1KSG3, Q9K0N4,

Geobacter sulfurreducens, Geobacter

Q5F6W5, A9M296,

metallireducens, Geobacter lovleyi,

Q9JVQ9, Q3KIA0,

Geobacter daltonii, Geobacter

A4XYF6, B7V1H3,

uraniireducens, Geobacter sp.,
Q9HV43, Q02FR1,

Geobacter bemidjiensis, Neisseria

A6VCL8, Q88DU2,

meningitidis, Neisseria meningitidis,

A5W9A3, Q4ZNP7,

Neisseria gonorrhoeae, Neisseria

Q1IF59, B1J254,

meningitidis, Neisseria meningitidis,

Q48E62, Q87WP0,

Pseudomonas fluorescens,

Q4KIH1, B0KIS5,

Pseudomonas mendocina,

A4VPQ5, B2UBP3,

Pseudomonas aeruginosa,

Q8XW40, B2FMY5,

Pseudomonas aeruginosa,

B4SSQ6

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas syringae,

Pseudomonas entomophila,

Pseudomonas putida, Pseudomonas

savastanoi, Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

stutzeri, Ralstonia pickettii, Ralstonia

solanacearum, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

1615
QRRQALRQLDG

Methylobacterium radiotolerans

B1M0E0
Q969Y2

1616
QRVAIARAI

Lactobacillus gasseri, Lactobacillus

Q042G7, Q74K65,
O75027

johnsonii, Lactobacillus delbrueckii,

Q1GB17, Q5FL41,

Lactobacillus acidophilus,

Q04BG2, Q1WV17,

Lactobacillus delbrueckii,

Q830W6, Q8Y8T6,

Lactobacillus salivarius, Enterococcus

Q72261, A0AGP9,

faecalis, Listeria monocytogenes,

Q92DL6, Q8DUF7

Listeria monocytogenes, Listeria

welshimeri, Listeria innocua,

Streptococcus mutans

1617
QRVTRASVTV

Citrobacter koseri, Enterobacter sp.,
A8AL53, A4WGB6,
Q8TEA8

Escherichia coli, Escherichia

B7N2M8, B7LVG2,

fergusonii, Escherichia coli,

Q1R431, B1LMS1,

Escherichia coli, Escherichia coli,

B6I4M4, B7NFI6,

Escherichia coli, Escherichia coli,

P0A6M4, A8A6Y8,

Escherichia coli, Escherichia coli,

B1IVJ1, Q0TAH5,

Escherichia coli, Escherichia coli,

P0A6M5, A1A164,

Escherichia coli, Escherichia coli,

C5A055, B1X1355,

Escherichia coli, Escherichia coli,

B7M686, B5YZ24,

Escherichia coli, Escherichia coli,

B7MI18, P0A6M6,

Escherichia coli, Escherichia coli,

B7L9D6, B7UNK4,

Escherichia coli, Escherichia coli,

A7ZU92, B7NUY4

Escherichia coli

1618
QSLAIIEYL

Rhizobium meliloti

Q9X4F7
O43708

1619
QSPDIAQGV

Streptomyces griseus, Streptomyces

B1W470, Q9L0Y3
P31153

coelicolor

1620
QSSNDTFPTA

Corynebacterium glutamicum,

Q8NRN8, Q8FQP8
P07954

Corynebacterium efficiens

1621
QTLLFSATMP

Bacillus licheniformis, Bacillus subtilis,

Q65N62, P96614,
Q9UJV9

Bacillus cereus, Bacillus thuringiensis,

Q73EU1, Q6HPE6,

Bacillus thuringiensis, Bacillus

A0R8U6, Q81VG0,

anthracis, Bacillus cereus, Bacillus

Q63GX5, Q81IT9

cereus

1622
QTREQHIRR

Pseudomonas aeruginosa,

Q9II37, C3JYR1,
P23378

Pseudomonas fluorescens,

Q3K7X5, Q88P65

Pseudomonas fluorescens,

Pseudomonas putida

1623
QVDTTNILF

Leuconostoc citreum, Rhizobium

B1MXT8, Q1MIM6,
O76Q31

leguminosarum, Rhizobium meliloti,

Q92QQ2, B5ZY09,

Rhizobium leguminosarum,

Q2K9U6, B3PVY5,

Rhizobium etli, Rhizobium etli,

C3MA45

Rhizobium sp.

1624
QVEHPVTEMITG

Escherichia coli, Escherichia coli,

P24182, Q8X9B6,
Q96R03

Haemophilus influenzae

P43873

1625
QVVAPSDMMDGR

Pseudomonas aeruginosa

Q59643
P13716

1626
QVVGDEGKGK

Arcobacter butzleri, Lactobacillus

A8ER43, Q88SV6,
Q8N142

plantarum, Lactobacillus salivarius,

Q1WRH2, B2G550,

Lactobacillus reuteri, Lactobacillus

A5VHM0, A8YTK4,

reuteri, Lactobacillus helveticus,

A7ZAP4, Q74KY3,

Bacillus methylotrophicus,

Q65CR5, Q5WAI0,

Lactobacillus johnsonii, Bacillus

A7GVN0, Q03TS9,

licheniformis, Bacillus clausii, Bacillus

Q045S7, A8FJC0,

cytotoxicus, Lactobacillus brevis,

Q9K5R0, B2GEZ1,

Lactobacillus gasseri, Bacillus

Q81JI9, A0RLP6,

pumilus, Bacillus halodurans,

Q6HAG9, Q72WW1,

Lactobacillus fermentum, Bacillus

Q630D5, Q814H1,

anthracis, Bacillus thuringiensis,

P29726, O68581,

Bacillus thuringiensis, Bacillus cereus,

P58793, A7I328,

Bacillus cereus, Bacillus cereus,

A0RMY9, B9KF91,

Bacillus subtilis, Fusobacterium

A7ZFJ4, A7H0A8,

nucleatum, Fusobacterium nucleatum,

A8AMM3, A3DK09,

Campylobacter hominis,

A5N4D3, B815L3,

Campylobacter fetus, Campylobacter

C6BRT2, A4W5R8,

lari, Campylobacter concisus,

Q839Y4, BILQJ7,

Campylobacter curvus, Citrobacter

Q1R383, B1IT29,

koseri, Clostridium thermocellum,

B1XDS8, B7NGB1,

Clostridium kluyveri, Clostridium

A1AJ82, B7MSJ5,

cellulolyticum, Desulfovibrio

B7LLV9, Q0T9L6,

salexigens, Enterobacter sp.,
P0A7D4, B7M8T7,

Enterococcus faecalis, Escherichia

P0A7D5, B6I281,

coli, Escherichia coli, Escherichia coli,

B7NTN3, A8A7S2,

Escherichia coli, Escherichia coli,

B7UQI6, B7LC36,

Escherichia coli, Escherichia coli,

C4ZR54, B5Z2I3,

Escherichia fergusonii, Escherichia

P0A7D6, B7MKY1,

coli, Escherichia coli, Escherichia coli,

A7ZV47, B6JKI4,

Escherichia coli, Escherichia coli,

Q1CUP8, B5ZA21,

Escherichia coli, Escherichia coli,

Q9ZMI1, P56137,

Escherichia coli, Escherichia coli,

B2US87, Q17W85,

Escherichia coli, Escherichia coli,

A6TH93, B5Y325,

Escherichia coli, Escherichia coli,

Q03W69, B1N002,

Escherichia coli, Helicobacter pylori,

B8DAL0, Q725A8,

Helicobacter pylori, Helicobacter

C1KV62, Q8YAR1,

pylori, Helicobacter pylori,

A0AEN2, Q92FQ5,

Helicobacter pylori, Helicobacter

Q03ET4, Q7MWW8,

pylori, Helicobacter acinonychis,

Q6A6A3, B4F271,

Klebsiella pneumoniae, Klebsiella

Q4KJ68, A4XPZ3,

pneumoniae, Leuconostoc

B1JA10, Q88DD8,

mesenteroides, Leuconostoc citreum,

A5W9S5, B0KKZ0,

Listeria monocytogenes, Listeria

Q3KIY4, B7V201,

monocytogenes, Listeria

Q02F80, Q9HUM6,

monocytogenes, Listeria

Q1I454, C3KDW8,

monocytogenes, Listeria welshimeri,

A6VD51, Q4ZYX5,

Listeria innocua, Pediococcus

Q48NZ7, Q87VJ9,

ntosaceus, Porphyromonas gingivalis,

Q98F97, Q92MA5,

Propionibacterium acnes, Proteus

Q2K4X9, B3PY13,

mirabilis, Pseudomonas fluorescens,

C3MI14, Q1MCS2,

Pseudomonas mendocina,

B5ZMS8, Q5HK16,

Pseudomonas putida, Pseudomonas

Q8CQK1, Q4LAK0,

putida, Pseudomonas putida,

Q9A1P8, Q1J8S0,

Pseudomonas putida, Pseudomonas

Q48VK8, Q1JIX0,

fluorescens, Pseudomonas

P0DD55, P0DD54,

aeruginosa, Pseudomonas

Q5M2A7, Q5LXQ5,

aeruginosa, Pseudomonas

C0MFY0, B9DT31,

aeruginosa, Pseudomonas

Q03IE5, Q8P2U1,

entomophila, Pseudomonas

Q5XE45, C0MAE4,

fluorescens, Pseudomonas

A2RCA2, Q1JNS3,

aeruginosa, Pseudomonas syringae,

B5XJH8, A8AZM9,

Pseudomonas savastanoi,

Q8DW14, Q04N48,

Pseudomonas syringae, Rhizobium

P65887, B8ZJJ5,

loti, Rhizobium meliloti, Rhizobium

P65888, A3CQU5,

etli, Rhizobium etli, Rhizobium sp.,
P65885, P65886,

Rhizobium leguminosarum,

Q3JZ68, A4W440

Rhizobium leguminosarum,

****

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus equi, Streptococcus

uberis, Streptococcus thermophilus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus equi, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus gordonii,

Streptococcus mutans, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

sanguinis, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus suis

1627
QWGDEGKGKV

Desulfitobacterium hafniense,

B8G0I5, Q24MC6,
Q8N142

Desulfitobacterium hafniense,

Q18107, B1H0H8

ptoclostridium difficile, Uncultured

termite

1628
QWGDEGKGKVVD

Parabacteroides distasonis,

A6LIF5, Q64QR7,
Q8N142

Bacteroides fragilis, Bacteroides

Q5LAD5, A6L1X1,

fragilis, Bacteroides vulgatus,

Q8A6N4, Q5H5T3,

Bacteroides thetaiotaomicron,

A7H5L7, A1W1A5,

Campylobacter jejuni, Campylobacter

A8FNG4, Q9PMG4,

jejuni, Campylobacter jejuni,

Q7VHL2

Campylobacter jejuni, Campylobacter

jejuni, Helicobacter hepaticus

1629
QWGDEGKGKVVD

Edwardsiella ictaluri

O31047
Q8N142

LL

1630
QYHPEFLSRP

Lactobacillus helveticus, Lactobacillus

A8YXF8, Q1GBQ2
P17812

delbrueckii

1631
QYLAAAGVG

Haemophilus influenzae

P45211
O95396

1632
RAAVPSGASTG

Clostridium kluyveri, Clostridium

A5N2N5, B9E6B1,
P06733

kluyveri, Clostridium beijerinckii,

A6LR09, B2TPW4,

Clostridium botulinum, Clostridium

B2UY16, AlVGV5,

botulinum, Desulfovibrio vulgaris,

Q72F92, A5GEW5,

Desulfovibrio vulgaris, Geobacter

B9M3M1, C6E471,

uraniireducens, Geobacter daltonii,

B5EGF2, Q39T27,

Geobacter sp., Geobacter
Q74AR6, B3E258,

bemidjiensis, Geobacter

B2FK88, B45R86

metallireducens, Geobacter

sulfurreducens, Geobacter lovleyi,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1633
RAAVPSGASTGI

Clostridium tetani

Q898R0
P06733

1634
RAAVPSGASTGIY

Clostridium perfringens, Clostridium

Q0STE0, Q0TQZ2,
P06733

EA

perfringens, Clostridium perfringens

Q8XKU4

1635
RAGGKHNDL

Aeromonas hydrophila, Aeromonas

A0KPG1, A4SS99,
P49588

salmonicida, Arcobacter butzleri,

A8EWI6, A8ANQ1,

Citrobacter koseri, Enterobacter sp.,
A4WDQ6, A8A3H4,

Escherichia coli, Escherichia coli,

B1LQ15, Q1R804,

Escherichia coli, Escherichia coli,

A1AEN7, A7ZQC5,

Escherichia coli, Escherichia coli,

Q8X3W8, Q0TEI3,

Escherichia coli, Escherichia coli,

P00957, B1XCM5,

Escherichia coli, Escherichia coli,

B1IUY2, A5GD98,

Geobacter uraniireducens,

Q0I426, A5UHW6,

Haemophilus somnus, Haemophilus

Q4QM86, A5UDR0,

influenzae, Haemophilus influenzae,

Q7VLK0, Q1CS22,

Haemophilus influenzae,

Q9ZJY5, Q17ZF3,

Haemophilus ducreyi, Helicobacter

P56452, B2UV04,

pylori, Helicobacter pylori,

A6TCV9, A9M198,

Helicobacter acinonychis,

A1KV20, Q5F7C4,

Helicobacter pylori, Helicobacter

Q9JTG4, Q9JYG6,

pylori, Klebsiella pneumoniae,

A4VJB3, Q02I63,

Neisseria meningitidis, Neisseria

Q9IS53, A6VA71,

meningitidis, Neisseria gonorrhoeae,

A4XWE2, Q885J0,

Neisseria meningitidis, Neisseria

Q4K843, Q4ZQI4,

meningitidis, Pseudomonas stutzeri,

Q1I6Z8, Q3K892,

Pseudomonas aeruginosa,

Q48G25, B0KR43,

Pseudomonas aeruginosa,

Q88EI8, A5W0D9,

Pseudomonas aeruginosa,

B1JCG9, Q8Y193

Pseudomonas mendocina,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas syringae,

Pseudomonas entomophila,

Pseudomonas fluorescens,

Pseudomonas savastanoi,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas putida, Ralstonia

solanacearum

1636
RAGGKHNDLD

Acinetobacter baumannii,

B0VAI3, A3M3W2,
P49588

Acinetobacter baumannii,

B2HWK7, Q6FCT2,

Acinetobacter baumannii,

B0UGC4, A9W5Y4,

Acinetobacter baylyi,

B1M0N0, B1ZC90,

Methylobacterium sp.,
P27866, Q2K7T4,

Methylobacterium extorquens,

Q1MFZ9, Q98NQ5,

Methylobacterium radiotolerans,

A5V3L0, B2FL33

Methylobacterium populi, Rhizobium

meliloti, Rhizobium etli, Rhizobium

leguminosarum, Rhizobium loti,

Sphingomonas wittichii,

Stenotrophomonas maltophilia

1637
RALFGTIDSWL

Sphingomonas wittichii

A5VE44
Q14409

1638
RASGAGGQH

Acinetobacter baumannii,

B2HU82, A3M6N7,
Q9UGC7

Acinetobacter baumannii,

B0VM26, B0V7E0,

Acinetobacter baumannii,

B7IBA1, B7H0L9,

Acinetobacter baumannii,

Q6F9S2, Q38WJ4,

Acinetobacter baumannii,

Q9JY93, AlKV95,

Acinetobacter baumannii,

Q9JT75, A9M1Q8,

Acinetobacter baylyi, Lactobacillus

Q5F750, B4RN52,

sakei, Neisseria meningitidis,

B2UDM7, Q8XVD0,

Neisseria meningitidis, Neisseria

B1GZI5

meningitidis, Neisseria meningitidis,

Neisseria gonorrhoeae, Neisseria

gonorrhoeae, Ralstonia pickettii,

Ralstonia solanacearum, Uncultured

termite

1639
RASGAGGQHVN

Aeromonas salmonicida, Aeromonas

A4SK64, A0KMZ8,
Q9UGC7

hydrophila, Desulfovibrio

B8J4R4, A1VAK8,

desulfuricans, Desulfovibrio vulgaris,

Q727E1, B8DLL6,

Desulfovibrio vulgaris, Desulfovibrio

Q39YQ1, Q74861,

vulgaris, Geobacter metallireducens,

Q1IEX1, B1JEP6,

Geobacter sulfurreducens,

Q88PW5, B0KNE4,

Pseudomonas entomophila,

A5VYG5

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas putida

1640
RAVLHVALR

Ralstonia pickettii

B2UF65
P06744

1641
RAVLHVALRNR

Desulfovibrio maeticus, Neisseria

C4XST3, Q9JYX3,
P06744

meningitidis, Neisseria meningitidis,

Q9JTW1, Q5F8P8

Neisseria gonorrhoeae

1642
RAVLHVALRNRSN

Citrobacter koseri, Enterobacter sp.,
A8ANA6, A4W5E0,
P06744

TPI

Klebsiella pneumoniae, Klebsiella

A6TGT4, B5XY03

pneumoniae

1643
RAVLHVALRNRSN

Escherichia fergusonii, Escherichia

B7LKZ8, B1LPI9,
P06744

TPILVDGKDVMPE

coli, Escherichia coli, Escherichia coli,

C5A0W2, B1IUM7,

VN

Escherichia coli, Escherichia coli,

P0A6T1, P0A6T2,

Escherichia coli, Escherichia coli,

B7LAX0, B1XC24,

Escherichia coli, Escherichia coli,

B5Z0C4, Q8FB44,

Escherichia coli, Escherichia coli,

Q0TA36, Q1R3R3,

Escherichia coli, Escherichia coli,

B7MRF7, A1AIK3,

Escherichia coli, Escherichia coli,

B7NRZ0, B7UPI6,

Escherichia coli, Escherichia coli,

B7MJ15, B615N7,

Escherichia coli, Escherichia coli,

A8A7C4, A7ZUP3,

Escherichia coli, Escherichia coli

B7M7T4, B7NFW8

1644
RDCSIQRRHQK

Bacillus halodurans

Q9KDS9
O00763

1645
RDCSVQRRHQK

Bacillus subtilis, Bacillus subtilis

O34544, Q9KWU4
Q13085

1646
RDGFVMGEGA

Bacillus subtilis, Staphylococcus

O34340, Q8NXE1,
Q9NWU1

aureus, Staphylococcus aureus,

Q6GAU2, Q5HHA1,

Staphylococcus aureus,

Q7A6F8, Q99VA6,

Staphylococcus aureus,

Q6GIA3, Q5TKS0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1647
RDGFVMGEGAAV

Streptomyces cyaneus

Q02578
Q9NWU1

LVLEE

1648
RDGKLYGRGS

Acinetobacter baumannii,

B0VRY3, B7GXA3,
Q96KP4

Acinetobacter baumannii,

B0V4V8, B7I842,

Acinetobacter baumannii,

A3M8H2, B2HY23

Acinetobacter baumannii,

Acinetobacter baumannii,

Acinetobacter baumannii

1649
RDHRKIGKE

Parabacteroides distasonis,

A6L952, Q64VP2,
A2RTX5

Bacteroides fragilis, Bacteroides

Q5LEQ6, A6L7J7,

fragilis, Bacteroides vulgatus,

Q8AAP2, Q97GK4,

Bacteroides thetaiotaomicron,

B2RJD6, Q7MVQ5,

Clostridium acetobutylicum,

Q2FXP7, Q8NW68,

Porphyromonas gingivalis,

A8Z2J8, Q6G8P3,

Porphyromonas gingivalis,

Q6GG23, A6QHL6,

Staphylococcus aureus,

Q5HF90, A5ITK7,

Staphylococcus aureus,

Q2FG54, A6U2F0,

Staphylococcus aureus,

Q2YTA7, B9DNC9,

Staphylococcus aureus,

P67584, P67585,

Staphylococcus aureus,

A7X3A6, Q49YB4

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus carnosus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus

1650
RDMKPENVL

Streptomyces toyocaensis

Q9KIG4
Q8WTQ7

1651
RDPRGFAVKFYTE

Pseudomonas putida

Q59714
P04040

1652
REGNDLYHEM

Clostridium botulinum, Clostridium

B2TKQ0, B2UZK0
P06576

botulinurn

1653
REILDSRGNPTVE

Porphyromonas gingivalis,

Q7MTV8, B2RLL7
P09104

VD

Porphyromonas gingivalis

1654
REKLDGLYECILC

Escherichia coli

P07014
P21912

ACCSTSCPS

1655
RELLAVPDNY

Ralstonia solanacearum

Q8Y0Z0
Q9Y617

1656
REQHIRRDKATSN

Bacillus subtilis, Bacillus cereus,

P54376, Q730W2,
P23378

IC

Bacillus thuringiensis, Bacillus cereus,

Q6HDT7, Q818M4,

Bacillus cereus, Bacillus cereus,

B7HB99, B7IXL3,

Bacillus cereus, Bacillus cereus,

B9IXL8, B7HNZ0,

Bacillus cereus, Bacillus cereus,

Q634V7, C1ERU9,

Bacillus cereus, Bacillus thuringiensis,

B7JMV0, A0RIL0,

Bacillus anthracis, Bacillus anthracis,

Q81M07, C3LKQ3,

Bacillus anthracis, Bacillus

C3P8D4, A9VH11,

weihenstephanensis, Bacillus

A7GSN7, Q65HG0,

cytotoxicus, Bacillus licheniformis,

A7Z6M3, A8FF40,

Bacillus methylotrophicus, Bacillus

Q92C05, Q71ZX3,

pumilus, Listeria innocua, Listeria

C1L2Q5, B8DFX9,

monocytogenes, Listeria

Q8Y7D4, A0AIF0,

monocytogenes, Listeria

B9DNN6, Q6GGG3,

monocytogenes, Listeria

P64218, P64217,

monocytogenes, Listeria welshimeri,

A5IT64, A6U207,

Staphylococcus carnosus,

A7X250, Q5HFM3,

Staphylococcus aureus,

Q8NWC9, Q2FY34,

Staphylococcus aureus,

Q2FGI6, Q6G930,

Staphylococcus aureus,

Q49XY0, Q4L6N6,

Staphylococcus aureus,

Q5HP13, Q8CMM0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1657
RERIPERVVHA

Streptomyces venezuelae,

P33569, Q9Z598
P04040

Streptomyces coelicolor

1658
RERIPERVVHAKG

Rhizobium meliloti

P95631
P04040

1659
RERIPERVVHAKG

Lactobacillus sakei

P30265
P04040

AGA

1660
RETDTMDTFV

Geobacter sulfurreducens, Geobacter

Q74AZ0, Q39T99,
O15031

metallireducens, Geobacter

A5G677, C6E100,

uraniireducens, Geobacter sp.,
B5EE39, B9M9F3

Geobacter bemidjiensis, Geobacter

daltonii

1661
RETDTMDTFVDS

Rhizobium etli, Rhizobium sp.,
Q2K257, C3MB60,
Q15031

Rhizobium leguminosarum,

Q1MA25, B3P546,

Rhizobium etli, Rhizobium

B5ZV40, Q92KW8,

leguminosarum, Rhizobium meliloti,

Q98EU7

Rhizobium loti

1662
REVDALDGL

Methylobacterium sp.,
B0UJI8, B1M186,
Q9Y2Z2

Methylobacterium radiotolerans,

B1ZGG2

Methylobacterium populi

1663
RFAPSPTGFLH

Aeromonas hydrophila, Aeromonas

A0KNT0, A4SJD4,
Q5JPH6

salmonicida, Methylobacterium sp.,
B0UQ09, B1Z9T1,

Methylobacterium populi,

A9W910

Methylobacterium extorquens

1664
RGANLSGGQ

Haemophilus influenzae

P71355
O15440

1665
RGERAYDIYSRLL

Lactobacillus fermentum,

B2GAL4, B3WCR2,
Q16740

Lactobacillus casei, Lactobacillus

Q03AL0, A7Z939,

casei, Bacillus methylotrophicus,

Q88YH9, P80244,

Lactobacillus plantarum, Bacillus

Q65EI5, Q74K84,

subtilis, Bacillus licheniformis,

Q042E8, Q1GB31,

Lactobacillus johnsonii, Lactobacillus

Q04BH7, Q631K2,

gasseri, Lactobacillus delbrueckii,

Q6HBD8, Q815J6,

Lactobacillus delbrueckii, Bacillus

Q72XW9, Q5FL55,

cereus, Bacillus thuringiensis, Bacillus

A8FHN9, Q81X63,

cereus, Bacillus cereus, Lactobacillus

A8YUD9, Q9K709,

acidophilus, Bacillus pumilus, Bacillus

Q38Y96, B2G613,

anthracis, Lactobacillus helveticus,

A5VI14, Q03SM3,

Bacillus halodurans, Lactobacillus

Q5WDK0, Q837R0,

sakei, Lactobacillus reuteri,

Q928C4, Q9RQI6,

Lactobacillus reuteri, Lactobacillus

Q71WV9, Q03GX1,

brevis, Bacillus clausii, Enterococcus

Q88KJ0, A5W635,

faecalis, Listeria innocua, Listeria

B1J692, B0KJG6,

monocytogenes, Listeria

Q1ICA8, Q4ZVM7,

monocytogenes, Pediococcus

Q87YR6, Q48KZ0,

ntosaceus, Pseudomonas putida,

Q3K9W9, Q4K9J6,

Pseudomonas putida, Pseudomonas

C3JYK0, A4XTZ5,

putida, Pseudomonas putida,

Q9I2U1, Q49VZ2,

Pseudomonas entomophila,

Q4L4J5, P63785,

Pseudomonas syringae,

P99089, P63786,

Pseudomonas syringae,

A8Z045, Q6GB62,

Pseudomonas savastanoi,

Q6GIM3, Q2G036,

Pseudomonas fluorescens,

A6QF76, Q5HHQ0,

Pseudomonas fluorescens,

Q2YSF8, A5IQX2,

Pseudomonas fluorescens,

A7WZR9, Q2F1M5,

Pseudomonas mendocina,

A6TZP7, B9DJL4,

Pseudomonas aeruginosa,

Q5HQW0, Q8CTE0,

Staphylococcus saprophyticus,

B2FQR2

Staphylococcus haemolyticus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus carnosus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Stenotrophomonas maltophilia

1666
RGFAVKFYT

Pseudomonas putida

P95539
P04040

1667
RGITIQSAAT

Bifidobacterium adolescentis,

A1A0T0, B1MW21,
096RP9

Leuconostoc citreum, Leuconostoc

Q03ZQ2, B2FQ42,

mesenteroides, Stenotrophomonas

B4SKW0

maltophilia, Stenotrophomonas

maltophilia

1668
RGKGLMIGIE

Bacillus cereus

Q818W2
Q9BYV1

1669
RGLDYYTGVI

Lactobacillus helveticus, Lactobacillus

A8YUZ9, Q5FKI5,
P12081

acidophilus, Lactobacillus gasseri,

Q043X4, Q1GAG8,

Lactobacillus delbrueckii,

Q04AV4

Lactobacillus delbrueckii

1670
RGRSINLAL

Pseudomonas fluorescens

Q84HF5
O15229

1671
RGSGGFGSTG

Helicobacter pylori, Helicobacter

B6JM89, Q1CT07,
P33316

pylori, Helicobacter pylori,

O25536, B2USW5,

Helicobacter pylori, Helicobacter

Q9ZKY3, Q17WJ4

pylori, Helicobacter acinonychis

1672
RHPFPGPGL

Acinetobacter baylyi, Aeromonas

Q6FFN2, A0KJS0,
P49915

hydrophila, Aeromonas salmonicida,

A4SM23, Q8RDR4,

Fusobacterium nucleatum, Citrobacter

A8AD80, Q18CT8,

koseri, ptoclostridium difficile,

C5BER5, A4WQ82,

Edwardsiella ictaluri, Enterobacter

B7UGU5, B7LKD4,

sp., Escherichia coli, Escherichia
P64294, Q0TEY1,

fergusonii, Escherichia coli,

B1LNF9, B7MYD5,

Escherichia coli, Escherichia coli,

A8A313, A1AE43,

Escherichia coli, Escherichia coli,

B6IS79, B1IWF4,

Escherichia coli, Escherichia coli,

B7M7L1, Q1R8M9,

Escherichia coli, Escherichia coli,

B7LCP7, B7NQV3,

Escherichia coli, Escherichia coli,

B7MHY8, B5Z0X6,

Escherichia coli, Escherichia coli,

P64295, B1XAY2,

Escherichia coli, Escherichia coli,

C4ZX82, P04079,

Escherichia coli, Escherichia coli,

A7ZPV1, B7N691,

Escherichia coli, Escherichia coli,

A5UG27, A5UAR3,

Escherichia coli, Haemophilus

A6TCC2, B5XNM4,

influenzae, Haemophilus influenzae,

A1KRY5, Q9JW60,

Klebsiella pneumoniae, Klebsiella

Q4ZX09, Q48LY0,

pneumoniae, Neisseria meningitidis,

Q886X5, Q4K6W4,

Neisseria meningitidis, Pseudomonas

Q3K7D0, B1JDH6,

syringae, Pseudomonas savastanoi,

C3K1K0, B2FNS1,

Pseudomonas syringae,

B4SSX7

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas putida, Pseudomonas

fluorescens, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

1673
RHPFPGPGLA

Helicobacter acinonychis,

Q17YH9, O25165,
P49915

Helicobacter pylori, Helicobacter

B6JMN5, Q1CSM2

pylori, Helicobacter pylori

1674
RHPFPGPGLAIR

Campylobacter jejuni, Campylobacter

Q5HTL3, A8FMV3,
P49915

jejuni, Helicobacter pylori,

Q9ZKG4, B2UUF1,

Helicobacter pylori, Rhizobium etli,

Q2KDG7, B3PYH7,

Rhizobium etli, Rhizobium

B5ZYE9, Q1MMJ7,

leguminosarum, Rhizobium

Q987R3

leguminosarum, Rhizobium loti

1675
RHPFPGPGLAIRVI

Desulfovibrio vulgaris

B8DNB9
P49915

1676
RIDHYLGKE

Rhizobium meliloti

Q9Z3S2
P11413

1677
RIDHYLGKEM

Streptococcus pneumoniae

O54537
P11413

1678
RIDHYLGKEMVQN

Leuconostoc mesenteroides

P11411
P11413

1679
RIINEPTAA

Clostridium novyi, Desulfovibrio

A0Q1R4, Q313S2
P11021

alaskensis

1680
RIINEPTAAA

Bacillus licheniformis, Clostridium

Q65H54, B2V2I5,
P11142

botulinum, Clostridium botulinum,

B2TLZ7, Q5HNW6,

Staphylococcus epidermidis,

Q8CP17, Q49Y22

Staphylococcus epidermidis,

Staphylococcus saprophyticus

1681
RIIVEKPFG

Haemophilus influenzae

P44311
P11413

1682
RI LLDAPCS

Pseudomonas aeruginosa,

Q9I7A9, Q88641,
Q8TEA1

Pseudomonas syringae,

Q88RR3

Pseudomonas putida

1683
RIRFTSPHP

Arcobacter butzleri

A8ERE9
Q965Z6

1684
RKICAIGVR

Bacteroides thetaiotaomicron,

Q8A858, Q64UP8,
A6NK58

Bacteroides fragilis, Bacteroides

Q5LDM3

fragilis

1685
RKLALKYHPD

Campylobacter hominis, Clostridium

A7I2G3, A5N6M3
Q8WW22

kluyveri

1686
RLAIARALL

Escherichia coli

P23886
Q2M3G0

1687
RLDILVNNAG

Pseudomonas aeruginosa

Q9RPT1
P15428

1688
RLEFLGDAIL

Pseudomonas aeruginosa,

A6VAK6, Q9XCX9,
Q9UPY3

Pseudomonas aeruginosa,

Q02HS2, B7UYX2,

Pseudomonas aeruginosa,

Q1I5V8, B0KV27,

Pseudomonas aeruginosa,

Q88MY5, A5W8F2,

Pseudomonas entomophila,

Q4KHT1, B1J4E0,

Pseudomonas putida, Pseudomonas

Q87XG1, Q4ZPE1,

putida, Pseudomonas putida,

Q48EV3, A4XSC4,

Pseudomonas fluorescens,

C3K6Y7, Q3KHL9

Pseudomonas putida, Pseudomonas

syringae, Pseudomonas syringae,

Pseudomonas savastanoi,

Pseudomonas mendocina,

Pseudomonas fluorescens,

Pseudomonas fluorescens

1689
RLEFLGDAILD

Bacteroides vulgatus, Bacteroides

A6KZ76, Q5LIS2,
Q9UPY3

fragilis, Bacteroides fragilis

Q64ZV9

1690
RLEYRGYDSAG

Corynebacterium glutamicum

Q8NND3
Q06210

1691
RLEYRGYDSAGV

Corynebacterium diphtheriae,

Q6NG33, Q8FNH2,
Q06210

Corynebacterium efficiens,

Q9HT25

Pseudomonas aeruginosa

1692
RLGFEGGQTP

Bacillus cereus, Bacillus

B7IT38, A9VP96,
Q9P015

weihenstephanensis, Bacillus

Q6HPN9, B9IZL3,

thuringiensis, Bacillus cereus, Bacillus

Q63H71, B7JKD8,

cereus, Bacillus cereus, Bacillus

C3LJA1, A0R8J9,

anthracis, Bacillus thuringiensis,

B7HQW3, C1ET58,

Bacillus cereus, Bacillus cereus,

Q81VR1, C3P9S4,

Bacillus anthracis, Bacillus anthracis,

Q73F77, Q81J23,

Bacillus cereus, Bacillus cereus,

B7HJ67, A7GK39,

Bacillus cereus, Bacillus cytotoxicus,

Q839E5, B5XJ55,

Enterococcus faecalis, Streptococcus

P0DE07, Q48VT0,

pyogenes, Streptococcus pyogenes,

Q1J8Z4, A2RC33,

Streptococcus pyogenes,

Q1JNZ8, Q1JE40,

Streptococcus pyogenes,

Q1JJ43, Q7CNP1,

Streptococcus pyogenes,

P0DE06, Q5XEB6,

Streptococcus pyogenes,

Q9A1V5, A8AZK6,

Streptococcus pyogenes,

C0ME24, B4U519,

Streptococcus pyogenes,

C0MBW6, A3CK83,

Streptococcus pyogenes,

C1CIB6, C1CPA7,

Streptococcus pyogenes,

C1CC25, B2IS59,

Streptococcus pyogenes,

Q8CVVV0, Q97SU3,

Streptococcus pyogenes,

B8ZKP9, B1I8L7,

Streptococcus gordonii,

C1CAN1, B5E6H4,

Streptococcus equi, Streptococcus

Q04ML7, Q8E2B5,

equi, Streptococcus equi,

Q3K3V0, Q8E752,

Streptococcus sanguinis,

B9DSW9

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus uberis

1693
RLKTGTPPR

Haemophilus ducreyi

Q7VPP9
Q9Y2Z2

1694
RLKTGTPPRI

Aeromonas salmonicida, Aeromonas

A4STQ4, A0KQY9,
Q9Y2Z2

hydrophila, Citrobacter koseri,

A8ACP7, A4WGE6,

Enterobacter sp., Haemophilus
P44763, Q4QMT9,

influenzae, Haemophilus influenzae,

A5UHB8, Q0I5W4,

Haemophilus influenzae,

A5U9Q7, A6TG45

Haemophilus somnus, Haemophilus

influenzae, Klebsiella pneumoniae

1695
RLLYVSCNP

Pseudomonas syringae

Q885Y8
Q8IZ69

1696
RLVLEVAQHLGE

Rhizobium meliloti, Rhizobium sp.,
Q92LK8, C3M9S1,
P06576

Rhizobium leguminosarum,

Q1MAZ2, B3PQ68,

Rhizobium etli, Rhizobium

B5ZSN7, Q2K3H0,

leguminosarum, Rhizobium etli,

A5V3X5

Sphingomonas wittichii

1697
RMTGGGFGGC

Haemophilus influenzae,

P31767, A5UDQ5,
P51570

Haemophilus influenzae,

A5UHX0, B8F7C7

Haemophilus influenzae,

Haemophilus parasuis

1698
RNIGIMAHIDAGKT

Porphyromonas gingivalis,

Q7MTL1, B2RLZ4
Q969S9

TT

Porphyromonas gingivalis

1699
RNIGIMAHIDAGKT

Micrococcus luteus

P09952
Q969S9

TTTER

1700
RNIGIMAHIDAGKT

Bacillus clausii, Bacillus halodurans,

Q5WLR5, Q9Z9L7,
Q969S9

TTTERIL

Bifidobacterium longum,

Q8G5B6, B3DT30,

Bifidobacterium longum,

B8DTV6, B8I5N7,

Bifidobacterium animalis, Clostridium

A1VEB9, Q72CI3

cellulolyticum, Desulfovibrio vulgaris,

Desulfovibrio vulgaris

1701
RNIGIMAHIDAGKT

Desulfovibrio vulgaris, Pediococcus

B8DN94, Q03EB4,
Q969S9

TTTERILYY

ntosaceus, Staphylococcus

Q4L3K8, Q5U859,

haemolyticus, Staphylococcus

B9DKV7, Q8CQ82,

intermedius, Staphylococcus

Q5HRK5, Q49V57,

Scarnosus, Staphylococcus

A6QEJ9, P68791,

epidermidis, Staphylococcus

P68790, Q6GBU0,

epidermidis, Staphylococcus

Q6GJC1, P68789,

saprophyticus, Staphylococcus

P68788, Q5HIC8,

aureus, Staphylococcus aureus,

Q2YSB4, A5IQA1,

Staphylococcus aureus,

Q2G0N1, Q2FJ93,

Staphylococcus aureus,

A6TZ24, A7WYX4

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1702
RNIGISAHID

Acinetobacter baumannii,

B0VTG3, B0V8Y3,
Q96RP9

Acinetobacter baumannii,

A3M306, B2HUQ4,

Acinetobacter baumannii,

B7I7S1, B7GYM8,

Acinetobacter baumannii,

Q6FDS6, A0KQ96,

Acinetobacter baumannii,

A8AQM8, C5BGM8,

Acinetobacter baumannii,

B7LS46, Q1R5U3,

Acinetobacter baylyi, Aeromonas

B6I240, B1LHE0,

hydrophila, Citrobacter koseri,

P0A6M8, B1IPV9,

Edwardsiella ictaluri, Escherichia

P0A6M9, Q0TCB9,

fergusonii, Escherichia coli,

A1AGM7, A8A5E7,

Escherichia coli, Escherichia coli,

C4ZUJ5, B1X6J0,

Escherichia coli, Escherichia coli,

B7M1P1, B7UK50,

Escherichia coli, Escherichia coli,

B7N0X6, B7NLP5,

Escherichia coli, Escherichia coli,

B5YTP7, P0A6N0,

Escherichia coli, Escherichia coli,

B7L4L1, B7MCV5,

Escherichia coli, Escherichia coli,

A7ZSL5, B7NDU8,

Escherichia coli, Escherichia coli,

P43925, A5U9R0,

Escherichia coli, Escherichia coli,

Q4QMT6, Q0I537,

Escherichia coli, Escherichia coli,

Q7VNA2, B8F7Z4,

Escherichia coli, Escherichia coli,

B4EYV7, Q8XV10,

Haemophilus influenzae,

Q8XRM7

Haemophilus influenzae,

Haemophilus influenzae,

Haemophilus somnus, Haemophilus

ducreyi, Haemophilus parasuis,

Proteus mirabilis, Ralstonia

solanacearum, Ralstonia

solanacearum

1703
RPRFGLLRGREF

Bacillus pumilus, Bacillus clausii,

A8FDC1, Q5WFT6,
Q7L3T8

Bacillus licheniformis, Bacillus

Q65JJ1, Q9KA71,

halodurans, Bacillus subtilis, Bacillus

O31755, A7Z4S8,

methylotrophicus, Bacillus cereus,

Q819Y4, B7HLF2,

Bacillus cereus, Bacillus cereus,

Q732Q0, B7HDU2,

Bacillus cereus, Bacillus

A9VT57, C1EP43,

weihenstephanensis, Bacillus cereus,

B7JJ97, C3L7A8,

Bacillus cereus, Bacillus anthracis,

C3P5M1, Q81WL6,

Bacillus anthracis, Bacillus anthracis,

A0RHJ2, Q6HEZ6,

Bacillus thuringiensis, Bacillus

Q636K7, B9IVA8,

thuringiensis, Bacillus cereus, Bacillus

B7IUH7, A7GRE9,

cereus, Bacillus cereus, Bacillus

Q044C3, Q74IS2,

cytotoxicus, Lactobacillus gasseri,

Q5FJN0, A8YVR3,

Lactobacillus johnsonii, Lactobacillus

A7I1R8, B8DG08,

acidophilus, Lactobacillus helveticus,

Q720A3, C1L2M5,

Campylobacter hominis, Listeria

Q8Y7G2, A0AIC0,

monocytogenes, Listeria

Q92C35, Q2YXK5,

monocytogenes, Listeria

Q6GHH2, Q5HGG8,

monocytogenes, Listeria

A8Z3U3, A6QGG3,

monocytogenes, Listeria welshimeri,

Q2FHH5, Q2G1Z4,

Listeria innocua, Staphylococcus

Q6G9V0, Q7A120,

aureus, Staphylococcus aureus,

Q7A5Y3, Q99UK9,

Staphylococcus aureus,

A7X1P3, A5ISE7,

Staphylococcus aureus,

A6U182, Q8C5T7,

Staphylococcus aureus,

Q5HPS8, Q4L5W5,

Staphylococcus aureus,

Q49X48

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus,

Staphylococcus saprophyticus

1704
RPRGGDFLYS

Rhizobium loti

Q98L96
Q9NTM9

1705
RPWTIRQYAGFST

Porphyromonas gingivalis

Q59677
P22033

1706
RQPEFTQID

Clostridium tetani

Q892B2
Q6PI48

1707
RQTLLFSAT

Escherichia coli, Pseudomonas

P21693, Q88NB7,
Q9UJV9

putida, Pseudomonas aeruginosa,

Q9HXE5, B7UUT0,

Pseudomonas aeruginosa,

Q02S21, Q887N8

Pseudomonas aeruginosa,

Pseudomonas syringae

1708
RQTLLFSATMP

Lactobacillus reuteri, Listeria

Q9Z6C9, Q8Y8N0,
Q9UJV9

monocytogenes, Streptococcus

P0A4D7, P0A4D8

pneumoniae, Streptococcus

pneumoniae

1709
RRGRYVEFNL

Aeromonas salmonicida, Aeromonas

A45T50, A0KEX7,
P36551

hydrophila, Enterobacter sp.,
A4WD41, B7M6U5,

Escherichia coli, Escherichia coli,

A7ZPN6, B1LMN0,

Escherichia coli, Escherichia coli,

B7N626, P36553,

Escherichia coli, Escherichia coli,

B1IWM6, A8A2T4,

Escherichia coli, Escherichia coli,

B1XAA7, C4ZX09,

Escherichia coli, Escherichia coli,

A1ADV0, Q8FFA3,

Escherichia coli, Escherichia coli,

Q0TF33, B7MY86,

Escherichia coli, Escherichia coli,

B7MHT7, B7UGD5,

Escherichia coli, Escherichia coli,

B7NPX2, B7LCI0,

Escherichia coli, Escherichia

B7LKJ9, B5YZY1,

fergusonii, Escherichia coli,

Q8XBI4, B6IS12,

Escherichia coli, Escherichia coli,

B5XVR1, A6TC68,

Klebsiella pneumoniae, Klebsiella

B4EZS7, Q3KKE0,

pneumoniae, Proteus mirabilis,

B0KF35, A5WVK4,

Pseudomonas fluorescens,

Q88RQ6, B1J4A2,

Pseudomonas putida, Pseudomonas

Q4KKQ4, A6UX86,

putida, Pseudomonas putida,

Q480H6, Q500S4,

Pseudomonas putida, Pseudomonas

B7VQ09, P43898,

fluorescens, Pseudomonas

Q02V57, Q1I2G6,

aeruginosa, Pseudomonas

Q88649, C3K4I0,

savastanoi, Pseudomonas syringae,

A4XNB8, Q8XXC3,

Pseudomonas aeruginosa,

B2U8Z4, B4SNL7,

Pseudomonas aeruginosa,

B2FND0

Pseudomonas aeruginosa,

Pseudomonas entomophila,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas mendocina, Ralstonia

solanacearum, Ralstonia pickettii,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1710
RRGRYVEFNLLYD

Rhizobium leguminosarum,

B5ZY73, B3PV29,
P36551

RGT

Rhizobium etli, Rhizobium

Q1MDJ5, Q92PD8,

leguminosarum, Rhizobium meliloti,

Q2K5S3

Rhizobium etli

1711
RRLLYVSCNP

Pseudomonas syringae,

Q4ZQ44, Q48FH7
Q8IZ69

Pseudomonas savastanoi

1712
RRLQVQERLT

Porphyromonas gingivalis,

Q7MWI5, B2RIJ1
P30793

Porphyromonas gingivalis

1713
RRVLRPGGVL

Pseudomonas aeruginosa

A6UYW3
Q6UX53

1714
RRVVITGIG

Rhizobium leguminosarum,

P04684, P72331,
Q9NWU1

Rhizobium sp., Streptomyces rimosus

P43678

1715
RSAVSIARR

Bacillus subtilis

O31489
Q8N5C6

1716
RSPLWRGGG

Desulfovibrio salexigens

C6C186
Q9BYD3

1717
RTDAGVHAL

Akkermansia muciniphila,

B2UNB6, B2G8U7,
Q8N0Z8

Lactobacillus reuteri, Lactobacillus

A5VLH4, B2GDT8,

reuteri, Lactobacillus fermentum,

Q45557, Q03PY8,

Bacillus sp., Lactobacillus brevis,
B9M6W5, A5GB00,

Geobacter daltonii, Geobacter

B2U6Z1, Q8XXX8

uraniireducens, Ralstonia pickettii,

Ralstonia solanacearum

1718
RTNTCGELR

Porphyromonas gingivalis,

B2RHE0, Q7MXM0
Q6PI48

Porphyromonas gingivalis

1719
RTSHYPYAEE

Escherichia coli

P05804
P08236

1720
RTTLLPGLL

Geobacter metallireducens,

Q39VS4, Q74CZ9,
Q9NSD9

Geobacter sulfurreducens,

Q828C6

Streptomyces avermitilis

1721
RVALIGDAAH

Pseudomonas putida

Q53552
Q9Y2Z9

1722
RVDFNVPMK

Bacillus megaterium, Bacillus clausii,

P24269, Q5WDK6,
P07205

Bacillus licheniformis, Bacillus

Q65EM9, A8FHJ3,

pumilus, Bacillus cereus, Bacillus

P62409, A7GUS0,

cytotoxicus, Bacillus cereus, Bacillus

Q631L9, P40924,

subtilis, Bacillus cereus, Bacillus

B7HW55, Q81X75,

anthracis, Bacillus anthracis, Bacillus

C3P0A6, C3LDI3,

anthracis, Bacillus cereus, Bacillus

B9J4M7, B7JFG6,

cereus, Bacillus thuringiensis, Bacillus

A0RKS6, C1EZA3,

cereus, Bacillus thuringiensis, Bacillus

Q6HBF0, B7IP23,

cereus, Bacillus cereus, Bacillus

B7HED5, A9VQ51,

weihenstephanensis, Bacillus

Q9K714, Q8Y4I2,

halodurans, Listeria monocytogenes,

B8DD98, Q928I0,

Listeria monocytogenes, Listeria

Q71WW8, C1KY97,

innocua, Listeria monocytogenes,

A0ALE2

Listeria monocytogenes, Listeria

welshimeri

1723
RVEAFSDGV

Streptomyces collinus

S5VBU1
Q9BSA9

1724
RVEEMRQSL

Pseudomonas fluorescens

C3JY83
O75306

1725
RVGIGRPAH

Bacillus clausii

Q5WAD6
Q86Y79

1726
RVILQDFTGVP

Streptococcus mutans

Q59938
P21399

1727
RVILQDFTGVPAV

Bacillus subtilis, Staphylococcus

P09339, Q8CPC2,
P21399

VD

epidermidis, Staphylococcus

Q5HPJ0, P63434,

epidermidis, Staphylococcus aureus,

Q6G9K9, P99148,

Staphylococcus aureus,

Q5HG69, P63433,

Staphylococcus aureus,

Q6GH55

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1728
RVLRLPAVA

Haemophilus somnus, Neisseria

Q0I5H4, Q9JWC5,
O15067

meningitidis, Neisseria meningitidis,

Q9JXK5, Q5F7J4

Neisseria gonorrhoeae

1729
RVRFAPSPTG

Bacillus clausii, Geobacter lovleyi,

Q5WLT5, B3E399,
Q5JPH6

Porphyromonas gingivalis,

B2RI67, Q7MUF7,

Porphyromonas gingivalis, Uncultured
B1H0J3

termite

1730
RVRIALALKG

Pseudomonas aeruginosa

P57109
O43708

1731
RVTVLGHVQRGG

ptoclostridium difficile, Listeria

Q180P4, A0AJ20,
P17858

welshimeri, Listeria monocytogenes,

Q8Y6W0, Q71Z96,

Listeria monocytogenes, Listeria

C1KVL8, B8DHH7,

monocytogenes, Listeria

Q92BE4

monocytogenes, Listeria innocua

1732
RVVDASIMP

Klebsiella pneumoniae

B5Y008
Q8NE62

1733
RYCINSAAL

Lactobacillus salivarius, Bacillus

Q1WVT3, A7Z5S1,
Q8IXL7

methylotrophicus, Bacillus subtilis,

P54155, Q9ZMK8,

Helicobacter pylori, Helicobacter

O25011, Q8XYL1,

pylori, Ralstonia solanacearum,

Q99ZV6, P0DC42,

Streptococcus pyogenes,

P0DC43, C0MDV8,

Streptococcus pyogenes,

Q8P172, Q5XCD0,

Streptococcus pyogenes,

C0M8H8, Q8E026,

Streptococcus equi, Streptococcus

Q3K1F5, Q8E5Q9,

pyogenes, Streptococcus pyogenes,

Q9LAM9

Streptococcus equi, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus gordonii

1734
RYLGDLSGGQV

Corynebacterium diphtheriae

P71119
P09601

1735
RYRQRYLDLI

Arcobacter butzleri, Bacillus

A8ESJ5, Q9KGG4,
Q15046

halodurans, Bacillus clausii, Bacillus

Q5WLU5, P37477,

subtilis, Bacillus weihenstephanensis,

A9VN90, B7ISY7,

Bacillus cereus, Bacillus cereus,

B7JK84, Q6HPU0,

Bacillus thuringiensis, Bacillus cereus,

Q63HC2, Q81VW3,

Bacillus anthracis, Bacillus

A0R8E9, Q81J70,

thuringiensis, Bacillus cereus, Bacillus

B7HJ16, B7HPY8,

cereus, Bacillus cereus, Bacillus

Q73FD1, A7GJY9,

cereus, Bacillus cytotoxicus,

A8AP96, A4WE42,

Citrobacter koseri, Enterobacter sp.,
Q839A8, P0A8N6,

Enterococcus faecalis, Escherichia

P0A8N5, Q8FAT5,

coli, Escherichia coli, Escherichia coli,

P0A8N4, P0A8N3,

Escherichia coli, Escherichia coli,

Q8XD57, Q7VLU5,

Escherichia coli, Haemophilus

A5UIX4, Q4QL88,

ducreyi, Haemophilus influenzae,

A5UCQ0, P43825,

Haemophilus influenzae,

P56126, B2USI3,

Haemophilus influenzae,

B6JPT1, B5Z9V6,

Haemophilus influenzae, Helicobacter

Q17YS1, Q1CUX6,

pylori, Helicobacter pylori,

Q9ZMP8, Q92F47,

Helicobacter pylori, Helicobacter

Q8YAB8, Q724I4,

pylori, Helicobacter acinonychis,

A0AF28, Q8CQV5,

Helicobacter pylori, Helicobacter

Q5HRN7, Q4L3H5,

pylori, Listeria innocua, Listeria

Q53638, Q6GJF4,

monocytogenes, Listeria

P67609, P67610,

monocytogenes, Listeria welshimeri,

Q5HIF7, Q2YVW8,

Staphylococcus epidermidis,

Q2FJC3, Q2G0Q3,

Staphylococcus epidermidis,

A7WYS8, Q49V26,

Staphylococcus haemolyticus,

Q8NXZ0, Q6GBX1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Staphylococcus aureus,

Staphylococcus aureus

1736
SAHGTNPASA

Bacillus halodurans, Bacillus clausii,

Q9K936, Q5WF32,
P23378

Bacillus cereus, Bacillus

P62029, A7Z6M2,

methylotrophicus, Bacillus

A7GSN6, A0RIK9,

cytotoxicus, Bacillus thuringiensis,

Q634V8, Q6HDT8,

Bacillus cereus, Bacillus thuringiensis,

C1ERU8, Q81M08,

Bacillus cereus, Bacillus anthracis,

C3P8D3, C3LKQ2,

Bacillus anthracis, Bacillus anthracis,

B7JMU9, B7HNY9,

Bacillus cereus, Bacillus cereus,

B9IXL7, B7IXL2,

Bacillus cereus, Bacillus cereus,

A9VH10, B7HB98,

Bacillus weihenstephanensis, Bacillus

P54377, Q818M5,

cereus, Bacillus subtilis, Bacillus

Q65HG1, A0AIF1,

cereus, Bacillus licheniformis, Listeria

Q8Y7D3, B8DFX8,

welshimeri, Listeria monocytogenes,

Q71ZX2, C1L2Q6,

Listeria monocytogenes, Listeria

Q92C04, Q49XX9,

monocytogenes, Listeria

Q4L6N5, Q2YSZ4,

monocytogenes, Listeria innocua,

Q8NWD0, A8Z474,

Staphylococcus saprophyticus,

Q6G931, Q2FY35,

Staphylococcus haemolyticus,

Q2FGI7, P99168,

Staphylococcus aureus,

P64219, A5IT63,

Staphylococcus aureus,

A7X2R9, A6U206,

Staphylococcus aureus,

Q6GGG4, A6QH79,

Staphylococcus aureus,

Q5HFM4, Q8CMM1,

Staphylococcus aureus,

Q5HP14

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1737
SCNIFSTQDH

Desulfovibrio alaskensis,

Q30WL8, A1VFZ7,
P23526

Desulfovibrio vulgaris, Desulfovibrio

Q72EH1, B8DR41,

vulgaris, Desulfovibrio vulgaris,

C6C1F4, P61617,

Desulfovibrio salexigens, Geobacter

Q98CM3

sulfurreducens, Rhizobium loti

1738
SCTTNCLAPLAKVI

Enterobacter aerogenes

P24163
O14556

1739
SDAFFPFRD

Aeromonas salmonicida, Aeromonas

A45R98, A0KGJ2,
P31939

hydrophila, Citrobacter koseri,

A8AKS0, Q0SV48,

Clostridium perfringens, Clostridium

Q0TTB0, Q8XMK2,

perfringens, Clostridium perfringens,

B2V3C3, B2TN76,

Clostridium botulinum, Clostridium

B7NRT9, B1XC09,

botulinum, Escherichia coli,

P15639, B1IUP1,

Escherichia coli, Escherichia coli,

C5A0U7, B7LAV3,

Escherichia coli, Escherichia coli,

B7LUJ6, B7NFU7,

Escherichia coli, Escherichia

B7MRD0, Q0TA59,

fergusonii, Escherichia coli,

B5Z0A3, Q8X611,

Escherichia coli, Escherichia coli,

B1LPG6, Q1R5X1,

Escherichia coli, Escherichia coli,

B7MIZ2, A1AIH7,

Escherichia coli, Escherichia coli,

B6I5L8, B7M7R5,

Escherichia coli, Escherichia coli,

A7ZUM3, A8A7A6,

Escherichia coli, Escherichia coli,

Q8FB68, B7UPG1,

Escherichia coli, Escherichia coli,

Q74FJ9, Q39RK1,

Escherichia coli, Escherichia coli,

A5G879, C6E5Z3,

Geobacter sulfurreducens, Geobacter

B5EBF9, B3E7F6,

metallireducens, Geobacter

B9M4Q6, Q0I557,

uraniireducens, Geobacter sp.,
P43852, B5XYD2,

Geobacter bemidjiensis, Geobacter

A6TGR3, B4RP71,

lovleyi, Geobacter daltonii,

Q5F6T1, A9M4I2,

Haemophilus somnus, Haemophilus

Q9JZM7, B4EYT2,

influenzae, Klebsiella pneumoniae,

A4VPK9, Q87VR9,

Klebsiella pneumoniae, Neisseria

C3K6E0, A4XQ60,

gonorrhoeae, Neisseria gonorrhoeae,

Q9HUV9, B7V1R6,

Neisseria meningitidis, Neisseria

A6VCVV0, B1J5T3,

meningitidis, Proteus mirabilis,

Q02FG6, Q4KIX5,

Pseudomonas stutzeri, Pseudomonas

Q1I4C1, A5W9K7,

syringae, Pseudomonas fluorescens,

Q88DK3, B0KJZ6,

Pseudomonas mendocina,

Q8Y232, B2UFL5

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas putida, Pseudomonas

aeruginosa, Pseudomonas

fluorescens, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

putida, Ralstonia solanacearum,

Ralstonia pickettii

1740
SDAYSTGSS

Campylobacter concisus,

A7ZC90, A7GXA8
P04424

Campylobactercurvus

1741
SDELNHASIIDGIR

Bacillus methylotrophicus, Bacillus

A7Z4X1, O31777,
O75600

L

subtilis, Bacillus pumilus

A8FDG9

1742
SDELNHASL

Corynebacterium kropnstedtii

C4LK80
O15270

1743
SDGIMVARGDLG

Methylobacterium extorquens

O05118
P30613

1744
SDHIETLYE

Geobacter bemidjiensis, Geobacter

B5EJ44, C6E7U2,
P22830

sp., Geobacter daltonii, Geobacter
B9M326, A5GDG7

uraniireducens

1745
SDVANAVLDGAD

Corynebacterium glutamicum

Q46078
P30613

1746
SEDMLGRVF

Clostridium novyi

A0PZC7
P15313

1747
SEKETGDRN

Clostridium perfringens

Q8XIW8
Q9UI32

1748
SERIRTYNF

Bacillus halodurans, Bacillus clausii,

Q9K6F4, Q5WB55,
O75570

Streptococcus pyogenes,

P0DD95, P0DD94,

Streptococcus pyogenes,

B5XLI8, Q48TL0,

Streptococcus pyogenes,

Q99ZP5, Q8DU64,

Streptococcus pyogenes,

Q03L79, Q5M0B7,

Streptococcus pyogenes,

Q5M4W4, Q5XC69,

Streptococcus mutans, Streptococcus

Q3K1I9, A2REH9,

thermophilus, Streptococcus

Q1J6M1, Q1JGV2,

thermophilus, Streptococcus

Q1JLQ2, Q1JBR9,

thermophilus, Streptococcus

Q8DZM4, Q8E5C3,

pyogenes, Streptococcus agalactiae,

A3CN05, P47850,

Streptococcus pyogenes,

Q8P125

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus sanguinis,

Streptococcus gordonii,

Streptococcus pyogenes

1749
SEVMLQQTQVAT

Escherichia coli, Haemophilus

P17802, P44320
Q9UIF7

VI

influenzae

1750
SFHSLEDRI

Geobacter daltonii

B9M164
A6NJ78

1751
SFHSLEDRIVK

Geobacter sulfurreducens, Geobacter

P60396, Q39YM7,
A6NJ78

metallireducens, Geobacter

A5G8K8, C6DZJ8,

uraniireducens, Geobacter sp.,
B5EBP3, A4XQR6,

Geobacter bemidjiensis,

Q02H20, Q9HVZ5,

Pseudomonas mendocina,

B7UZJ8, A6VB93,

Pseudomonas aeruginosa,

Q1I5130, B0KFT4,

Pseudomonas aeruginosa,

A5W8Q8, Q88N84,

Pseudomonas aeruginosa,

B1J1Y2

Pseudomonas aeruginosa,

Pseudomonas entomophila,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas putida

1752
SFITPVPGGVGPM

Campylobacter hominis,

A7I254, A7GXK2
P11586

T

Campylobacter curvus

1753
SFTGSTQVG

Pseudomonas putida

P43503
P49419

1754
SFTKGCYIGQE

Haemophilus influenzae

P44000
Q5T440

1755
SGAGGQHVN

Lactobacillus reuteri, Lactobacillus

B2G676, B3WDK7,
Q9UGC7

casei, Lactobacillus casei,

Q03A29, Q4K695,

Pseudomonas fluorescens,

Q48MV4, Q4ZXW7,

Pseudomonas savastanoi,

P42806, B7V0L1,

Pseudomonas syringae,

Q02G09, C3KDC6,

Pseudomonas aeruginosa,

A6VC61, B4SKS8,

Pseudomonas aeruginosa,

B2FQ14

Pseudomonas aeruginosa,

Pseudomonas fluorescens,

Pseudomonas aeruginosa,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1756
SGAGGQHVNTTD

Citrobacter koseri, Edwardsiella

A8AG02, C5B814,
Q9UGC7

SA

ictaluri, Enterobacter sp., Escherichia
A4WBC6, B7UQ99,

coli, Escherichia fergusonii,

B7LSH9, B619S6,

Escherichia coli, Escherichia coli,

B1LH89, Q1RCM7,

Escherichia coli, Escherichia coli,

B1IU82, B7N422,

Escherichia coli, Escherichia coli,

P0A7I0, A1AAD8,

Escherichia coli, Escherichia coli,

P0A7I1, A7ZZE7,

Escherichia coli, Escherichia coli,

Q0TIF9, P0A7I2,

Escherichia coli, Escherichia coli,

B1XAQ2, C4ZTQ2,

Escherichia coli, Escherichia coli,

B7LXC6, B5YXM9,

Escherichia coli, Escherichia coli,

B7NUX7, A7ZKY5,

Escherichia coli, Escherichia coli,

B7LGX2, B7MKB3,

Escherichia coli, Escherichia coli,

B7MTZ5, A6TAN9,

Klebsiella pneumoniae, Proteus

B4EVR7, A4XR61,

mirabilis, Pseudomonas mendocina,

Q3K6W9

Pseudomonas fluorescens

1757
SGAGGQHVNTTD

Geobacter lovleyi, Geobacter

B3E628, A5G8T7,
Q9UGC7

SAVRI

uraniireducens, Staphylococcus

Q4L7Z9, Q5HMA4,

haemolyticus, Staphylococcus

Q8CNI7, Q6GEV7,

epidermidis, Staphylococcus

Q2YUN5, A8YY83,

epidermidis, Staphylococcus aureus,

P66020, Q6G7J2,

Staphylococcus aureus,

P66019, P66018,

Staphylococcus aureus,

A6QIW2, Q5HE82,

Staphylococcus aureus,

Q2FF10, A5IUR3,

Staphylococcus aureus,

Q2FWE0, A6U3K3,

Staphylococcus aureus,

A7X4W4, Q49Z65

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus

1758
SGAGKSSLI

Acinetobacter baylyi

Q6FAN3
Q6NXR0

1759
SGAGKSSLL

Escherichia coli, Escherichia coli,

P0AAF7, P0AAF6,
Q8N139

Escherichia coli, Pseudomonas

P0AAF8, Q1IGN4,

entomophila, Pseudomonas putida

Q88RB3

1760
SGAGKSTLLN

Haemophilus ducreyi

Q7VP69
Q94911

1761
SGAGKSTLM

Fusobacterium nucleatum

Q8REG7
P45844

1762
SGAHLNPAV

Pseudomonas aeruginosa

Q51389
P29972

1763
SGAHLNPAVT

Escherichia coli, Escherichia coli,

P0AER0, P0AER1,
P29972

Escherichia coli, Haemophilus

P0AER2, P44826,

influenzae, Streptomyces coelicolor

P19255

1764
SGDLAPLSH

Streptomyces avermitilis,

Q82I33, P24221,
P42357

Streptomyces griseus, Streptomyces

Q9EWW1

coelicolor

1765
SGEPMDKAG

Clostridium perfringens, Clostridium

Q0SR36, Q0TNG7,
O95671

perfringens, Clostridium perfringens,

Q8XIH4, Q9K0J8,

Neisseria meningitidis, Neisseria

Q9JVK3

meningitidis

1766
SGFPKNRVIG

Bacillus clausii, Bacillus halodurans,

Q5WEG2, Q9K849,
P00338

Fusobacterium nucleatum

Q8RED8

1767
SGGGSGHEPAH

Citrobacter freundii

P45510
Q3LXA3

1768
SGGPNSVYA

Streptococcus equi, Streptococcus

C0MAM2, P64299,
P49915

pyogenes, Streptococcus pyogenes,

B5XLN9, Q1J6G5,

Streptococcus pyogenes,

P64300, Q48TF6,

Streptococcus pyogenes,

Q1JGP6, Q5XC20,

Streptococcus pyogenes,

C0MFC7, P0DB55,

Streptococcus pyogenes,

P0DB54, Q1JBM8,

Streptococcus pyogenes,

Q1JLL1, A2RED2,

Streptococcus equi, Streptococcus

Q8DZX7, Q8E5M8,

pyogenes, Streptococcus pyogenes,

Q3K1C0, B9DUB2

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus uberis

1769
SGGPNSVYAEDA

Streptococcus thermophilus,

Q5M4P4, Q5M029
P49915

Streptococcus thermophilus

1770
SGGQKQRIA

Leuconostoc mesenteroides

Q10418
Q9NRK6

1771
SGGQKQRISLAR

Escherichia coli

Q9X2W0
Q96J66

1772
SGHKIYGPKG

Edwardsiella ictaluri

C5BEU5
Q9Y697

1773
SGHWEHYQEDMF

Streptococcus uberis, Streptococcus

B9DU13, A3CP56,
Q9BW92

sanguinis, Streptococcus equi

C0MCN7

1774
SGIGRAVSV

Bacillus subtilis, Bacillus subtilis

P80873, P40397
Q92506

1775
SGILVQLPLP

Helicobacter pylori

Q9ZLQ4
Q9H903

1776
SGKGGVGKS

Bacillus subtilis, Escherichia coli,

P40742, P0AF09,
P53384

Escherichia coli, Haemophilus

P0AF08, P45135,

influenzae, Helicobacter pylori

O25678

1777
SGKGGVGKST

Bacillus subtilis, Clostridium

P50863, P53381,
P53384

perfringens, Helicobacter pylori,

O24999, Q9ZMM5,

Helicobacter pylori, Helicobacter

O25098, Q9ZMA8,

pylori, Helicobacter pylori,

P72190

Pseudomonas fragi

1778
SGLRGRGGAGFP

Desulfovibrio fructosivorans,

Q46507, Q9XAQ9
P49821

TG

Streptomyces coelicolor

1779
SGLRGRGGAGFP

Rhizobium meliloti

P56912
P49821

TGLKWSFM

1780
SGLRLGTPA

Staphylococcus carnosus,

B9DMF3, B4SJB0,
P34896

Stenotrophomonas maltophilia,

B2FNK2

Stenotrophomonas maltophilia

1781
SGLRLGTPALT

Campylobacter jejuni, Campylobacter

A7H4X6, Q5HW65,
P34896

jejuni, Campylobacter jejuni,

A8FKI9, P24531,

Campylobacter jejuni, Campylobacter

A1VYC2

jejuni

1782
SGPLVRSSY

Corynebacterium urealyticum,

B1VHG8, Q4JWE0,
O43766

Corynebacterium jeikeium,

C3PHK6, Q8FNP4,

Corynebacterium aurimucosum,

Q9S2P2

Corynebacterium efficiens,

Streptomyces coelicolor

1783
SGPSGAGKST

Fusobacterium nucleatum

Q8RHI9
Q16774

1784
SGPSGAGKSTLLK

Campylobacter jejuni, Campylobacter

Q5HTT7, Q9PNB8
Q16774

jejuni

1785
SGSGKTTLL

Bacillus subtilis, Bacillus subtilis,

O34697, P42423,
Q9H222

Bacillus halodurans, Haemophilus

Q9K619, Q57213,

influenzae, Pseudomonas

Q3KCC5, Q92VJ2,

fluorescens, Rhizobium meliloti,

Q98K23, Q92XW1

Rhizobium loti, Rhizobium meliloti

1786
SGTDGVGTK

Finegoldia magna

B0S0R2
P22102

1787
SGTDGVGTKL

Acinetobacter baumannii,

B0VT70, B2HWV2,
P22102

Acinetobacter baumannii,

A3M7X8, B0VDJ1,

Acinetobacter baumannii,

B7GY98, B7I5C6,

Acinetobacter baumannii,

Q6F973, A0KM24,

Acinetobacter baumannii,

A4SL28, Q1G9G0,

Acinetobacter baumannii,

Q049L9, Q1WU57,

Acinetobacter baylyi, Aeromonas

Q9KF55, Q5FIV3,

hydrophila, Aeromonas salmonicida,

Q5WJ84, A8YW83,

Lactobacillus delbrueckii,

B2GF76, Q6HPA2,

Lactobacillus delbrueckii,

A0R8Z8, C1EV65,

Lactobacillus salivarius, Bacillus

B7JM87, Q81ZH0,

halodurans, Lactobacillus acidophilus,

C3L534, C3PBN2,

Bacillus clausii, Lactobacillus

A9VRF3, B9J1K7,

helveticus, Lactobacillus fermentum,

Q73EN3, A7GKI0,

Bacillus thuringiensis, Bacillus

B7HS34, B7IUV5,

thuringiensis, Bacillus cereus, Bacillus

Q63GT1, B7H4T8,

cereus, Bacillus anthracis, Bacillus

Q81IQ1, A5VHU0,

anthracis, Bacillus anthracis, Bacillus

B2G5C0, B3DT56,

weihenstephanensis, Bacillus cereus,

Q8G595, B7GU81,

Bacillus cereus, Bacillus cytotoxicus,

A1A0R8, B8DTT6,

Bacillus cereus, Bacillus cereus,

C3L2V1, Q97J93,

Bacillus cereus, Bacillus cereus,

A7GH98, B1IL59,

Bacillus cereus, Lactobacillus reuteri,

C1FV78, A7FXD5,

Lactobacillus reuteri, Bifidobacterium

B1KZ57, C5BHQ4,

longum, Bifidobacterium longum,

A4WD72, Q833Z1,

Bifidobacterium longum,

B7LKE3, B6I571,

Bifidobacterium adolescentis,

Q1R8N9, B7MHY0,

Bifidobacterium animalis, Clostridium

B7MYC7, Q8XAC5,

botulinum, Clostridium

B5Z036, B1IWG1,

acetobutylicum, Clostridium

A8A2Z1, Q8FF72,

botulinum, Clostridium botulinum,

B7M7K3, B7N681,

Clostridium botulinum, Clostridium

B1LNF0, B7LCN9,

botulinum, Clostridium botulinum,

Q0TEY9, P08178,

Edwardsiella ictaluri, Enterobacter

C4ZX74, B1XAX4,

sp., Enterococcus faecalis,
A7ZPU2, B7UGN7,

Escherichia fergusonii, Escherichia

B7NQN8, A5UC39,

coli, Escherichia coli, Escherichia coli,

A5UEU3, P43848,

Escherichia coli, Escherichia coli,

Q4QKF3, Q0I5D1,

Escherichia coli, Escherichia coli,

B8F5E6, A6TCB3,

Escherichia coli, Escherichia coli,

B5XNQ0, A0AJM1,

Escherichia coli, Escherichia coli,

Q71YQ1, C1KW66,

Escherichia coli, Escherichia coli,

B8DDZ0, Q92AP1,

Escherichia coli, Escherichia coli,

Q8Y6C3, B4EY89,

Escherichia coli, Escherichia coli,

A4XWN5, Q48FI4,

Escherichia coli, Escherichia coli,

Q4K8A5, B0KT52,

Escherichia coli, Haemophilus

A5W7R7, Q88MA9,

influenzae, Haemophilus influenzae,

Q4ZQ51, Q885Y1,

Haemophilus influenzae,

B1J1M3, C3K102,

Haemophilus influenzae,

Q1IDL2, Q3KFT0,

Haemophilus somnus, Haemophilus

Q9I513, B7UXY9,

parasuis, Klebsiella pneumoniae,

Q02IA6, Q9F1T6,

Klebsiella pneumoniae, Listeria

C1CNS6, B2IR37,

welshimeri, Listeria monocytogenes,

Q97TA2, C1CBM4,

Listeria monocytogenes, Listeria

B8ZJN0, C1C9V1,

monocytogenes, Listeria innocua,

B1I7V5, Q9A1Z0,

Listeria monocytogenes, Proteus

Q8E7W9, Q8DRM4,

mirabilis, Pseudomonas mendocina,

Q04N22, C1CHV9,

Pseudomonas savastanoi,

Q8E2G1, A2RBZ5,

Pseudomonas fluorescens,

Q3K400, Q5XEF4,

Pseudomonas putida, Pseudomonas

Q1J936, Q8P312,

putida, Pseudomonas putida,

B5XJ18, P0DD63,

Pseudomonas syringae,

P0DD62, B5E5J6,

Pseudomonas syringae,

Q1JJ82, Q1JE80,

Pseudomonas putida, Pseudomonas

Q48VX3, A8AU99,

fluorescens, Pseudomonas

A3CJZ4, B9DSR4,

entomophila, Pseudomonas

Q1JP36, Q8DWL1,

fluorescens, Pseudomonas

Q5M203, Q5M6J5,

aeruginosa, Pseudomonas

Q03MZ8

aeruginosa, Pseudomonas

aeruginosa, Streptococcus suis,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus gordonii,

Streptococcus sanguinis,

Streptococcus uberis, Streptococcus

pyogenes, Streptococcus mutans,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus thermophilus

1788
SGTDGVGTKLK

Bacillus subtilis, Bacillus pumilus,

P12043, A8FAM9,
P22102

Bacillus methylotrophicus, Bacillus

A7Z251, Q65MS6,

licheniformis, Desulfitobacterium

B8FP03, Q24QH4,

hafniense, Desulfitobacterium

A9KHX3, B3E3K3,

hafniense, Clostridium

B5EFU7, C6E6M9,

phytofermentans, Geobacter lovleyi,

Q9JUA2, A9LZD2,

Geobacter bemidjiensis, Geobacter

A1KU60, Q5F973,

sp., Neisseria meningitidis, Neisseria
Q9JZ80, Q8XW52,

meningitidis, Neisseria meningitidis,

Q49WJ5, Q4L580,

Neisseria gonorrhoeae, Neisseria

Q5HQ99, Q8CT29,

meningitidis, Ralstonia solanacearum,

Q2YX52, Q5HH13,

Staphylococcus saprophyticus,

A8Z1L3, Q2FI07,

Staphylococcus haemolyticus,

Q2FZI8, A6QFS9,

Staphylococcus epidermidis,

A6U0N9, P67721,

Staphylococcus epidermidis,

P99163, A5IRV8,

Staphylococcus aureus,

A7X0W4, Q8NX90,

Staphylococcus aureus,

Q6GAE2, Q6GI13,

Staphylococcus aureus,

B9DQ40, B45N29,

Staphylococcus aureus,

B2FRX8

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus carnosus,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1789
SGTDGVGTKLKIA

Clostridium kluyveri, Clostridium

B9E4K8, A5N0Q2,
P22102

kluyveri, Clostridium cellulolyticum,

B8I492, A0Q1J2,

Clostridium novyi, Clostridium

A3DEV1, Q74CB6,

thermocellum, Geobacter

B9M1P4, A5G3H3,

sulfurreducens, Geobacter daltonii,

Q39UK1

Geobacter uraniireducens, Geobacter

metallireducens

1790
SGVGKSSLV

Bacteroides thetaiotaomicron

Q8A8H7
Q5HYI8

1791
SGWDFSSRW

Citrobacter koseri, Escherichia coli,

A8AFT6, Q0TIH3,
O43280

Escherichia coli, Escherichia coli,

B7UQ86, B1LHA4,

Escherichia coli, Escherichia coli,

B7NUW3, B619Q8,

Escherichia coli, Escherichia coli,

P13482, B1IU96,

Escherichia coli, Escherichia coli,

A7ZZD1, B1XAN8,

Escherichia coli, Escherichia coli,

C4ZTN8, B7N408,

Escherichia coli, Escherichia coli,

Q8CVV46, B7LGV7,

Escherichia coli, Escherichia coli,

Q1RCP3, B7MK99,

Escherichia coli, Escherichia coli,

A7ZKW9, A1AAC5,

Escherichia coli, Escherichia coli

Q8XDH7, B7LXB1

1792
SIPVIANGDI

Escherichia coli, Escherichia coli,

P0ABT5, P0ABT6,
O95620

Escherichia coli, Klebsiella

P0ABT7, O52536

pneumoniae

1793
SIRDVIAFPK

Bifidobacterium longum,

Q8G863, B7GPT0,
Q6PI48

Bifidobacterium longum,

B3DPM0

Bifidobacterium longum

1794
SIWAPSQTL

Bacillus subtilis, Bacillus halodurans

P18185, Q9K8V7
P27708

1795
SKAGVIGLT

Clostridium scindens

P07914
Q92506

1796
SKKARDGKL

Escherichia coli

P06959
O00330

1797
SKPGEPSWP

Edwardsiella ictaluri

C5B8V6
P49589

1798
SKPLKGARI

Bacteroides fragilis, Bacteroides

Q64MT2, Q8A407
P23526

thetaiotaomicron

1799
SLKKLQLDY

Escherichia coli, Escherichia coli

Q46857, Q8XBT6
P17516

1800
SLLGGGGVDG

Citrobacter koseri, Klebsiella variicola,

A8AI35, D3RKJ0,
Q9BQ69

Klebsiella pneumoniae

B5XXK9

1801
SLNVSVAAG

Acinetobacter baylyi

Q6FF50
Q6IN84

1802
SLPNSRIMIHQP

Helicobacter hepaticus

Q7VIN7
Q16740

1803
SLWPMTFGLACC

Bacillus weihenstephanensis, Bacillus

A9VS97, Q6HAY6,
O75251

A

thuringiensis, Bacillus cereus, Bacillus

Q630U9, A0RL90,

thuringiensis, Bacillus cereus, Bacillus

B9IRT1, Q81K01,

anthracis, Bacillus cereus, Bacillus

Q814W7, C3P1E8,

anthracis, Bacillus cereus, Bacillus

C1F0M2, B7HY57,

cereus, Bacillus cereus, Bacillus

B7HFJ5, C3LFH3,

anthracis, Bacillus cereus, Bacillus

Q72XF4, B7JGM4,

cereus, Bacillus cereus, Bacillus

B7IQV2, A7GV50,

cytotoxicus, Desulfovibrio vulgaris

B8DS03

1804
SLWPMTFGLACC

Ralstonia solanacearum, Ralstonia

Q8XXQ2, B2U7R0
O75251

AVEMMH

pickettii

1805
SMCEHHLVPF

Bacillus methylotrophicus, Bacillus

A7Z630, A8FEL2,
P30793

pumilus, Bacillus subtilis, Bacillus

P19465, A7GN48,

cytotoxicus, Bacillus

A9VMC0, B9IVN3,

weihenstephanensis, Bacillus cereus,

Q6HL44, Q63DM1,

Bacillus thuringiensis, Bacillus cereus,

Q81FQ8, C1EN08,

Bacillus cereus, Bacillus cereus,

B7HL21, Q73AY4,

Bacillus cereus, Bacillus cereus,

B7HHR5, B7IP89,

Bacillus cereus, Bacillus cereus,

B7JGZ6, Q81SW2,

Bacillus cereus, Bacillus anthracis,

C3L8S8, C3P598,

Bacillus anthracis, Bacillus anthracis,

A0RBW5, Q8XLM2,

Bacillus thuringiensis, Clostridium

Q0STY9, Q0TRM0,

perfringens, Clostridium perfringens,

Q8NM84, A4QH94,

Clostridium perfringens,

Q71Y82, C1KWN3,

Corynebacterium glutamicum,

Q8Y5X1, Q92A75,

Corynebacterium glutamicum, Listeria

B8DBZ3, A0AK45,

monocytogenes, Listeria

Q5LYM8, Q5M391,

monocytogenes, Listeria

Q8DZI5, Q3K0Y1,

monocytogenes, Listeria innocua,

Q8E549, A4W1S9,

Listeria monocytogenes, Listeria

A4WH1, Q8DUG2

welshimeri, Streptococcus

thermophilus, Streptococcus

thermophilus, Streptococcus

agalactiae, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus suis, Streptococcus

suis, Streptococcus mutans

1806
SMRIMTRMG

Corynebacterium diphtheriae,

Q6NET5, C4LGT5,
P35558

Corynebacterium kropnstedtii,

Q8FM16, Q4JY04,

Corynebacterium efficiens,

A4QHQ4, Q9AEM1

Corynebacterium jeikeium,

Corynebacterium glutamicum,

Corynebacterium glutamicum

1807
SNASCTTNC

Staphylococcus epidermidis,

Q8CNY0, Q5HNL7,
O14556

Staphylococcus epidermidis,

Q6GG19, Q6G8N9,

Staphylococcus aureus,

P64181, P99067,

Staphylococcus aureus,

P64180, Q5HF86

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1808
SNASDALDK

Desulfovibrio vulgaris, Desulfovibrio

Q728G0, Q313E8,
P14625

alaskensis, Streptomyces coelicolor

P58481

1809
SNHGGRQLD

Pseudomonas putida

P20932
Q9NYQ3

1810
SNPVDILTY

Corynebacterium glutamicum,

Q8NLN0, A4QHW5,
Q9BYZ2

Corynebacterium glutamicum,

P62050, Q92F65,

Corynebacterium diphtheriae, Listeria

Q724K3, P33380

innocua, Listeria monocytogenes,

Listeria monocytogenes

1811
SPAEKAGLQ

Haemophilus influenzae

P44936
Q5T2W1

1812
SPCGACRQV

Bacillus subtilis

P19079
P32320

1813
SPDKDVDGFH

Neisseria meningitidis, Neisseria

P0C277, Q9JWI9,
P13995

meningitidis, Neisseria meningitidis,

A9M068, A1KWF4,

Neisseria meningitidis, Neisseria

B4RQN5, Q5F5D0

gonorrhoeae, Neisseria gonorrhoeae

1814
SPNGKLRLL

Geobacter lovleyi, Geobacter

B3E2M3, Q39UC4,
P09467

metallireducens, Geobacter

A5G439

uraniireducens

1815
SPRFRGEHALRR

Methylobacterium sp.,
B0ULL2, B8IUV4,
O00217

YP

Methylobacterium nodulans,

Q92QP4, Q98KR4

Rhizobium meliloti, Rhizobium loti

1816
SPRQSDVMI

Rhizobium etli, Rhizobium etli,

B3PY57, Q2K3U4,
O75251

Rhizobium meliloti

P56897

1817
SQGRLESLLN

Pseudomonas savastanoi,

Q48ME3, Q4ZXH2,
P23378

Pseudomonas syringae,

Q887L5

Pseudomonas syringae

1818
SQSGETADTL

Bacteroides thetaiotaomicron,

Q8AAB1, Q890U2,
Q06210

Clostridium tetani, Geobacter

Q74GH6, Q98LX5,

sulfurreducens, Rhizobium loti,

P08633, Q92ZK3,

Rhizobium leguminosarum,

Q92P54, P25195

Rhizobium meliloti, Rhizobium

meliloti, Rhizobium meliloti

1819
SQSSNDTFPTAM

Campylobacter jejuni

O69294
P07954

1820
SQWGHDFRP

Bacillus subtilis

O34748
P46063

1821
SRHPFPGPGLAIR

Arcobacter butzleri

A8ETA7
P49915

1822
SRQRYWGTPIPI

Sphingomonas wittichii

A5VA89
Q15031

1823
SRTDAGVHAL

Bacillus cereus, Bacillus cereus,

Q63GF1, Q73E17,
Q8N0Z8

Bacillus anthracis, Bacillus

Q6I3T8, Q6HNW5,

thuringiensis, Bacillus cereus

Q813Z9

1824
SRTRVKTLA

Propionibacterium acnes

Q6AAI8
P46926

1825
SRVALVTGA

Streptomyces cinnamonensis

P41177
O75828

1826
SSGSACTSA

Acinetobacter baumannii,

B0VD51, B7H3H0,
Q9Y697

Acinetobacter baumannii,

B2HZI5, B715Q3,

Acinetobacter baumannii,

B0VNW2

Acinetobacter baumannii,

Acinetobacter baumannii

1827
SSGSACTSASLEP

Haemophilus parasuis, Haemophilus

B8F356, Q0I1L2,
Q9Y697

SYVLRA

somnus,, Haemophilus influenzae,

Q57337, A5UGI1,

Haemophilus influenzae,

A5UAA8, A9M029,

Haemophilus influenzae, Neisseria

A1KUK1, Q9JTX0,

meningitidis, Neisseria meningitidis,

B4RMB8, Q5F8X4,

Neisseria meningitidis, Neisseria

A4VNY2, B7UWH7,

gonorrhoeae, Neisseria gonorrhoeae,

Q9HXI8, Q02RW8,

Pseudomonas stutzeri, Pseudomonas

A4XY43, A6V0U8,

aeruginosa, Pseudomonas

Q3K7A5, C3K1M5,

aeruginosa, Pseudomonas

Q4K6T8

aeruginosa, Pseudomonas

mendocina, Pseudomonas

aeruginosa, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas

fluorescens

1828
SSGSACTSASLEP

Haemophilus ducreyi

Q7VMA9
Q9Y697

SYVLRAIG

1829
SSPNTAGLR

Stenotrophomonas maltophilia,

B2FPI7, B4STK4
Q02127

Stenotrophomonas maltophilia

1830
SSRTDAGVHA

Clostridium kluyveri, Clostridium

A5N4T0, A6LPU5
Q8N0Z8

beijerinckii

1831
SSRTDAGVHAL

Clostridium tetani

Q890R5
Q8N0Z8

1832
STGGGASLE

Bifidobacterium longum,

B7GQU7, B3DRV9,
P07205

Bifidobacterium longum,

Q8G6D6, Q4JVJ3,

Bifidobacterium longum,

A4QEG1, Q01655,

Corynebacterium jeikeium,

B1VDQ4, C3PG40,

Corynebacterium glutamicum,

Q8FT66, C5CBP5

Corynebacterium glutamicum,

Corynebacterium urealyticum,

Corynebacterium aurimucosum,

Corynebacterium efficiens,

Micrococcus luteus

1833
STGGGASLEL

Arcobacter butzleri, Campylobacter

A8EWM4, A7GWT1,
P07205

curvus, Campylobacter concisus,

A7ZEZ5, Q5HT15,

Campylobacter jejuni, Campylobacter

A8FN77, Q9PMQ5,

jejuni, Campylobacter jejuni,

A1W116, A0RQT4,

Campylobacter jejuni, Campylobacter

A7I1G1, A7H5C5,

fetus, Campylobacter hominis,

C4LIR6

Campylobacter jejuni,

Corynebacterium kropnstedtii

1834
STGGGASLELLEG

Corynebacterium diphtheriae,

P62411, B8J4D3
P07205

K

Desulfovibrio desulfuricans

1835
STGGGASLELLEG

Helicobacter hepaticus, Helicobacter

Q7VJB6, P56154,
P07205

KILP

pylori, Helicobacter pylori

Q9ZJP1

836
STGVPHILEH

Clostridium perfringens

Q46205
Q5JRX3

1837
STNHKDIGTLYL

Rhizobium leguminosarum

Q08855
P00395

1838
SVAFDLATHRGYD

Rhizobium meliloti

O86028
P22033

SD

1839
SVFAGVGERTRE

Acinetobacter baylyi, Acinetobacter

Q6FFK0, A3M144,
P06576

GND

baumannii, Acinetobacter baumannii,

B0VNK4, B0VBP3,

Acinetobacter baumannii,

B7H294, B7I1W4,

Acinetobacter baumannii,

B2II02, A1KW11,

Acinetobacter baumannii,

A9M123, Q9JW70,

Acinetobacter baumannii, Neisseria

Q9JXQ2, B2FHY8,

meningitidis, Neisseria meningitidis,

B4SJR9

Neisseria meningitidis, Neisseria

meningitidis, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

1840
SVFAGVGERTRE

Desulfitobacterium hafniense,

Q24MP1, B8FZ34
P06576

GNDL

Desulfitobacterium hafniense

1841
SVLEMSHRS

Streptococcus suis, Streptococcus

A4VU42, A4W0D4,
Q9Y617

suis, Streptococcus uberis,

B9DTW4, Q03JH6,

Streptococcus thermophilus,

Q5LYP0, Q5M3A4

Streptococcus thermophilus,

Streptococcus thermophilus

1842
SVLFVCLGNICRS

Bacillus subtilis

Q35016
P24666

P

1843
SVSDKTGLV

Lactobacillus casei, Lactobacillus

B3WF93, Q037V3,
P31939

casei, Leuconostoc citreum

B1MY42

1844
SVSDKTGLVE

Stenotrophomonas maltophilia,

B45L92, B2FJP9
P31939

Stenotrophomonas maltophilia

1845
SVVGTSSLRR

Enterobacter sp., Klebsiella
A4WG12, A6TGI8,
P08397

pneumoniae, Klebsiella pneumoniae,

B5XYL1, B4F1X3,

Proteus mirabilis, Proteus mirabilis,

Q59684, Q1I316,

Pseudomonas entomophila,

Q4K3X3, Q02EA3,

Pseudomonas fluorescens,

B7V5F0, Q60169,

Pseudomonas aeruginosa,

A6VE37

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa

1846
SYAAVPLYR

Rhizobium etli, Rhizobium

Q2KBM0, B5ZSV4,
Q9Y6N1

leguminosarum, Rhizobium

Q1MKI3, B3PSB4

leguminosarum, Rhizobium etli

1847
SYEARAFGV

Rhizobium loti, Rhizobium loti,

Q98NW7, Q98JM5,
Q9Y253

Streptococcus pneumoniae,

Q975C7, Q8DQZ7,

Streptococcus pneumoniae,

Q04M21

Streptococcus pneumoniae

1848
TAARGRGKS

Citrobacter koseri, Escherichia coli

A8ADB3, P76562
Q9H0A0

1849
TAMTGDGVND

Streptococcus pneumoniae

P35597
O14983

1850
TAVLIETLV

Acinetobacter baylyi,

Q6FA43, P61456,
P23526

Corynebacterium diphtheriae,

Q4ZZ92, Q4K4H7,

Pseudomonas syringae,

Q3K5D7, B0KMQ0,

Pseudomonas fluorescens,

Q48PB5, Q87V73,

Pseudomonas fluorescens,

Q1I3W5, A5WA09,

Pseudomonas putida, Pseudomonas

B1J2Y8, C3K3G6,

savastanoi, Pseudomonas syringae,

B5ZV80, Q1MNC6,

Pseudomonas entomophila,

Q2KE72, B3PVW2,

Pseudomonas putida, Pseudomonas

Q8GGL7, Q82DC9,

putida, Pseudomonas fluorescens,

B1VUW6, Q9KZM1,

Rhizobium leguminosarum,

Q936D6

Rhizobium leguminosarum,

Rhizobium etli, Rhizobium etli,

Streptomyces atroolivaceus,

Streptomyces avermitilis,

Streptomyces griseus, Streptomyces

coelicolor, Streptomyces argillaceus

1851
TDGERILGLGD

Acinetobacter baylyi

Q6FFL8
P48163

1852
TDGVGTKLK

Desulfovibrio vulgaris, Desulfovibrio

B8DNV5, Q311C7
P22102

alaskensis

1853
TDKTGTLTQ

Escherichia coli, Escherichia coli

P0ABB8, P0ABB9
O43861

1854
TDTVVISMGQ

Sphingomonas wittichii

A5V656
P00480

1855
TDTVVISMGQE

Campylobacter hominis

A7I3W8
P00480

1856
TDVTNASRT

Corynebacterium efficiens,

Q8FLY8, B1LWN6
Q14409

Methylobacterium radiotolerans

1857
TDVTNASRTML

Streptomyces avermitilis,

Q828K5, Q9ADA7
Q14409

Streptomyces coelicolor

1858
TDVTNASRTMLFN

Parabacteroides distasonis

A6LCZ1
Q14409

I

1859
TDVTNASRTMLFN

Lactobacillus reuteri, Lactobacillus

B2G7U6, A5VKE8
Q14409

IH

reuteri

1860
TEGCRGEGG

Escherichia coli, Escherichia coli,

P0AC41, P0AC42,
P31040

Escherichia coli

P0AC43

1861
TEGCRGEGGIL

Escherichia coli, Haemophilus

P00363, P44894,
P31040

influenzae, Proteus vulgaris

P20922

1862
TEPGAGSDV

Citrobacter koseri, Escherichia

A8ALR4, B7LWN0,
P11310

fergusonii, Escherichia coli,

Q1RGF9, B1LFX2,

Escherichia coli, Escherichia coli,

B6HYZ0, P60584,

Escherichia coli, Escherichia coli,

B7N7R4, A7ZVY9,

Escherichia coli, Escherichia coli,

A1A789, C4ZPW5,

Escherichia coli, Escherichia coli,

B1XBG4, B7NHE3,

Escherichia coli, Escherichia coli,

B7MNP6, B5YYD3,

Escherichia coli, Escherichia coli,

B7L4G2, B7UI85,

Escherichia coli, Escherichia coli,

P60586, B7MAG2,

Escherichia coli, Escherichia coli,

A7ZHD0, B7M0D6,

Escherichia coli, Escherichia coli,

Q0TLV0, Q8GB20,

Proteus sp., Proteus mirabilis
B4EY23

1863
TERVLYYTG

Rhizobium loti

Q98N59
Q96RP9

1864
TFDSGGISIK

Aeromonas hydrophila, Aeromonas

A0KPF3, A4SSA7,
P28838

salmonicida, Citrobacter koseri,

A8AMA5, A4WF25,

Enterobacter sp., Escherichia coli,
B6I2H3, Q1R2Z4,

Escherichia coli, Escherichia coli,

B1LRE5, B7NGJ2,

Escherichia coli, Escherichia coli,

P68767, P68766,

Escherichia coli, Escherichia coli,

B1ISB1, A1AJG3,

Escherichia coli, Escherichia coli,

A8A816, Q0T9D1,

Escherichia coli, Escherichia coli,

B7M9L9, B1XEN9,

Escherichia coli, Escherichia coli,

C4ZRD1, B7NUH4,

Escherichia coli, Escherichia coli,

B7MSZ3, B7LCX0,

Escherichia coli, Escherichia coli,

B5Z3L7, B7MLR5,

Escherichia coli, Escherichia coli,

P68768, A7ZVE0,

Escherichia coli, Escherichia coli,

B7UQR7, B7LMT2,

Escherichia fergusonii, Klebsiella

B5Y2T8, A6THI2,

pneumoniae, Klebsiella pneumoniae,

B4F2N1

Proteus mirabilis

1865
TFGCGSAIASSS

Klebsiella pneumoniae

P05343
Q9H1K1

1866
TFGFRGEAL

Clostridium novyi

A0QQM7
P54278

1867
TFGGNPMACA

Neisseria meningitidis, Neisseria

Q9JTX9, Q9JYY4
Q9BYV1

meningitidis

1868
TFGLACCAVEMM

Neisseria meningitidis, Neisseria

Q9K1C2, A1KRS3,
O75251

H

meningitidis, Neisseria gonorrhoeae,

B4RPI3, Q5F616,

Neisseria gonorrhoeae, Neisseria

A1INN9

meningitidis

1869
TFGPTFRAE

Fusobacterium nucleatum,

Q8RH70, A5N4F7,
Q96159

Clostridium kluyveri, Clostridium

Q97E56

acetobutylicum

1870
TFGPTFRAENS

Aeromonas hydrophila, Bacillus

A0KIC3, Q6HCVV9,
Q96159

thuringiensis, Bacillus cereus, Bacillus

Q633N6, Q81L32,

anthracis, Bacillus cereus, Bacillus

Q72ZI3, A7GTK8,

cytotoxicus, Bacillus cereus,

Q817I8, Q24MK1,

Desulfitobacterium hafniense,

A6LIA1, Q5L8W2,

Parabacteroides distasonis,

A6L0U5, Q64P24,

Bacteroides fragilis, Bacteroides

Q8A0Z8, A0PY64,

vulgatus, Bacteroides fragilis,

A3DBI2, Q0TMF3,

Bacteroides thetaiotaomicron,

P58693, Q0SQ51,

Clostridium novyi, Clostridium

Q899M9, A5HZE1,

thermocellum, Clostridium

A7FRK8, B2UXS0,

perfringens, Clostridium perfringens,

A7GB01, B2TI01,

Clostridium perfringens, Clostridium

A6LPI6, Q317J6,

tetani, Clostridium botulinum,

Q72G53, AlV9B8,

Clostridium botulinum, Clostridium

Q1RDS7, P0A8M0,

botulinum, Clostridium botulinum,

B1IW01, P0A8M1,

Clostridium botulinum, Clostridium

Q0TJC3, A7ZYN3,

beijerinckii, Desulfovibrio alaskensis,

A7ZK21, P58694,

Desulfovibrio vulgaris, Desulfovibrio

Q74E08, Q39SY7,

vulgaris, Escherichia coli, Escherichia

A5G5R2, A5UF16,

coli, Escherichia coli, Escherichia coli,

A5UCB9, P43829,

Escherichia coli, Escherichia coli,

Q0I2M9, B8F3Y5,

Escherichia coli, Escherichia coli,

A6T726, Q7MVE5,

Geobacter sulfurreducens, Geobacter

B2RK42

metallireducens, Geobacter

uraniireducens, Haemophilus

influenzae, Haemophilus influenzae,

Haemophilus influenzae,

Haemophilus somnus, Haemophilus

parasuis, Klebsiella pneumoniae,

Porphyromonas gingivalis,

Porphyromonas gingivalis

1871
TFNDDIQGT

Bacillus subtilis

P45868
P48163

1872
TFNMDEYVG

Proteus mirabilis

B4ESJ0
P46926

1873
TFNMDEYVGL

Enterobacter sp., Haemophilus
A4W844, Q7VKN1,
P46926

ducreyi, Porphyromonas gingivalis,

B2RJ01, Q7MW43

Porphyromonas gingivalis

1874
TFNMDEYVGLP

Aeromonas hydrophila, Aeromonas

A0KIG3, A4SPM2,
P46926

salmonicida, Parabacteroides

A6LHV2, Q64XP2,

distasonis, Bacteroides fragilis,

Q5LGU0, Q8A094,

Bacteroides fragilis, Bacteroides

A6L7Q8, A8AJE0,

thetaiotaomicron, Bacteroides

C6C0A2, Q8FJX7,

vulgatus, Citrobacter koseri,

B7LKT5, Q1REP9,

Desulfovibrio salexigens, Escherichia

B1LLC0, B6HYN6,

coli, Escherichia fergusonii,

B7N9S4, P0A759,

Escherichia coli, Escherichia coli,

B1IY50, Q0TK13,

Escherichia coli, Escherichia coli,

A7ZXT7, A1A8T7,

Escherichia coli, Escherichia coli,

B1X6L1, B7M5J6,

Escherichia coli, Escherichia coli,

C4ZWF4, B7NMM9,

Escherichia coli, Escherichia coli,

B7MPI3, P0A760,

Escherichia coli, Escherichia coli,

B5YQM0, B7UKV0,

Escherichia coli, Escherichia coli,

B7L9L4, B7MFT4,

Escherichia coli, Escherichia coli,

A7ZJ60, Q0I4B9,

Escherichia coli, Escherichia coli,

B8F877, B5XZG9,

Escherichia coli, Escherichia coli,

A6T6C1

Haemophilus somnus, Haemophilus

parasuis, Klebsiella pneumoniae,

Klebsiella pneumoniae

1875
TFVAELKGL

Haemophilus somnus, Haemophilus

Q0I491, P44427,
P40926

influenzae, Haemophilus influenzae,

A5UCQ1, A5UIX3,

Haemophilus influenzae,

Q4QL89

Haemophilus influenzae

1876
TGAAQGIGR

Pseudomonas putida

P23102
P15428

1877
TGAGISTASG

Enterococcus faecalis

Q839C6
Q8N6T7

1878
TGARGLRSI

Lactobacillus reuteri, Lactobacillus

A5VJ94, Q88VE2,
O76031

plantarum, Lactobacillus salivarius,

Q1WU81, Q03QN7,

Lactobacillus brevis, Enterococcus

Q833M7, Q03W09,

faecalis, Leuconostoc mesenteroides,

Q03F27

Pediococcus ntosaceus

1879
TGASSGIGE

Listeria innocua

Q92EK7
Q9Y394

1880
TGASSGIGEE

Staphylococcus saprophyticus

Q49WS9
Q9Y394

1881
TGEISPGMI

Desulfovibrio alaskensis

Q3QZW0
P60174

1882
TGGIASGKS

Streptococcus pyogenes,

P58102, Q48UU5,
Q8WVC6

Streptococcus pyogenes,

P0DA44, Q5XDE3,

Streptococcus pyogenes,

P0DA45, P63834,

Streptococcus pyogenes,

Q8DSZ0

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans

1883
TGHAEWRV

Ralstonia solanacearum

Q8Y1C6
Q9UJ68

1884
TGIKWDLL

Clostridium phytofermentans,

A9KK92, B8DRD2,
P06576

Desulfovibrio vulgaris, Desulfovibrio

Q72E04, A1VFJ5,

vulgaris, Desulfovibrio vulgaris,

Q313W0, B8J439

Desulfovibrio alaskensis,

Desulfovibrio desulfuricans

1885
TGIKVVDLLAPY

Arcobacter butzleri, Bacillus

A8EV70, P41009,
P06576

caldotenax, Bacillus halodurans,

Q9K6H5, A7GV56,

Bacillus cytotoxicus, Bacillus sp.,
P07677, P12698,

Bacillus megaterium, Bacillus

P22478, B9IRT7,

pseudofirmus, Bacillus cereus,

B7HY64, Q72XE8,

Bacillus cereus, Bacillus cereus,

A0RL95, Q6HAY0,

Bacillus thuringiensis, Bacillus

Q81JZ5, Q630U3,

thuringiensis, Bacillus anthracis,

C1F0M8, C3LFH9,

Bacillus cereus, Bacillus cereus,

C3P1F4, Q65DX4,

Bacillus anthracis, Bacillus anthracis,

B7JGN0,
A9VSA3,

Bacillus licheniformis, Bacillus cereus,

Q5W378, Q814W2,

Bacillus weihenstephanensis, Bacillus

B7HFK1, B7IQV8,

clausii, Bacillus cereus, Bacillus

A8FIB2, P37809,

cereus, Bacillus cereus, Bacillus

Q180W5, A6LQH6

pumilus, Bacillus subtilis,

ptoclostridium difficile, Clostridium

beijerinckii

1886
TGIKVVDLLAPYA

Campylobacter jejuni, Campylobacter

Q0PC30, A1VXJ0,
P06576

jejuni, Campylobacter jejuni,

Q5HX59, A8FJR2,

Campylobacter jejuni, Campylobacter

A7ZC37, A7H1I1,

concisus, Campylobacter jejuni,

A7H017, B9KES3,

Campylobacter curvus,

A0RR26, A7I177,

Campylobacter lari, Campylobacter

B81579

fetus, Campylobacter hominis,

Clostridium cellulolyticum

1887
TGLSGAGKTT

Pseudomonas aeruginosa

P29811
O43252

1888
TGPCGPCSEI

Clostridium thermocellum

A3DKB6
P49588

1889
TGPNMGGKS

Neisseria gonorrhoeae, Neisseria

Q5F5J4, A9M4L8,
P20585

meningitidis, Neisseria meningitidis,

A1KWM6, B4RPP9,

Neisseria gonorrhoeae, Neisseria

Q9JWT7, Q9JX94,

meningitidis, Neisseria meningitidis,

Q2KD76, Q1MMA5,

Rhizobium etli, Rhizobium

P56883, Q98C21

leguminosarum, Rhizobium meliloti,

Rhizobium loti

1890
TGPNMGGKSTY

Haemophilus ducreyi

Q7VKA1
P43246

1891
TGPNMSGKSTY

Streptococcus pneumoniae,

C1CH06, C1CN23,
O15457

Streptococcus pneumoniae,

B8ZPK0, C1CAQ5,

Streptococcus pneumoniae,

Q04I96, P0A3R3,

Streptococcus pneumoniae,

P0A3R4, B1I9E5

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

1892
TGQDGSYLAEFLL

Escherichia coli, Escherichia coli,

P0AC90, P0AC88,
O60547

EKGYEVHGI

Escherichia coli

P0AC89

1893
TGRKIIVDTY

Lactobacillus casei, Lactobacillus

B3WCC9, Q03AU4,
Q00266

casei, Clostridium botulinum,

B2UZL0, B2TK10,

Clostridium botulinum, Clostridium

A0Q2Y4, B0S2I6,

novyi, Finegoldia magna,

Q03VI4, B1N092

Leuconostoc mesenteroides,

Leuconostoc citreum

1894
TGRTHQIRVH

Bacillus subtilis, Bacillus subtilis,

Q45480, O31613,
Q8IZ73

Escherichia coli, Escherichia coli,

Q8X8J3, P0AA39,

Escherichia coli, Escherichia coli,

Q8FIP7, P65834,

Escherichia coli, Escherichia coli,

Q8X9F0, P33643,

Haemophilus ducreyi, Haemophilus

P59835, P44433,

influenzae, Haemophilus influenzae,

P44445, Q9L7A7,

Haemophilus ducreyi, Neisseria

Q9JVB6, Q9K0B0,

meningitidis, Neisseria meningitidis,

Q9HZM9, P33640,

Pseudomonas aeruginosa,

Q8XYX8

Pseudomonas aeruginosa, Ralstonia

solanacearum

1895
TGRTHQIRVHL

Bacillus subtilis, Helicobacter pylori,

P54604, Q9ZKP5,
Q8IZ73

Helicobacter pylori

O25610

1896
TGSFKIRGA

Escherichia coli, Escherichia coli,

P0AGF7, P0AGF6,
Q9GZT4

Escherichia coli

P0AGF8

1897
TGSGKSSLL

Haemophilus influenzae

P45081
Q96J66

1898
TGSGKSTLL

Bacillus licheniformis

Q65P76
P13569

1899
TGTDEHGLK

Rhizobium loti

Q98MV8
Q96GW9

1900
TGTDEHGLKI

Lactobacillus plantarum

Q88Z97
Q96GW9

1901
TGTPWGGLT

Proteus mirabilis, Proteus mirabilis

B4F1A3, Q7X3P1
P05089

1902
THGSLEVGK

Pseudomonas fluorescens,

Q3KJE5, Q4KJN0
Q96NU7

Pseudomonas fluorescens

1903
THIRLNIFPDGGIA

Acinetobacter baumannii

B2I1L5
Q8N6M5

RLRV

1904
THLGLPVFNTV

Escherichia coli, Escherichia coli,

P0AGF0, P0AGE9,
P53597

Escherichia coli, Haemophilus

P0AGF1, P45102

influenzae

1905
THLGLPVFNTVKE

Pseudomonas aeruginosa

Q51567
P53597

A

1906
TIAFGIRNV

Geobacter daltonii, Geobacter

B9LZA9, A5GA37,
Q5HYK3

uraniireducens, Geobacter

Q74EU2

sulfurreducens

1907
TIGKGFQGV

Rhizobium loti

Q98N57
P09001

1908
TIIEPTSGNTGIGL

Bacillus subtilis

P37887
P35520

A

1909
TIMENIRFG

Bacillus subtilis

O31708
Q9NUT2

1910
TIMGHVDHGKT

Campylobacter lari

B9KEV0
P46199

1911
TITMVGDLK

Parabacteroides distasonis

A6LA97
P27708

1912
TKDGVTVAK

Acinetobacter baylyi,

Q6F8P6, B1ZAU5,
P10809

Methylobacterium populi,

B1LVA0, B8DJC4,

Methylobacterium radiotolerans,

A5G9I2, Q747C7,

Desulfovibrio vulgaris, Geobacter

B5E9Y2, C6DY43,

uraniireducens, Geobacter

B9LZ35, Q39ZP5,

sulfurreducens, Geobacter

A9M0Q6, A1KW52,

bemidjiensis, Geobacter sp.,
P57006, P42385,

Geobacter daltonii, Geobacter

B4RRA1, Q5F541,

metallireducens, Neisseria

P29842, Q981J9,

meningitidis, Neisseria meningitidis,

Q98IH9, Q6W1D5,

Neisseria meningitidis, Neisseria

Q983S4, Q98AX9,

meningitidis, Neisseria gonorrhoeae,

Q6W163, Q92ZQ4,

Neisseria gonorrhoeae, Neisseria

Q98IV5, A5VBQ6

gonorrhoeae, Rhizobium loti,

Rhizobium loti, Rhizobium sp.,

Rhizobium loti, Rhizobium loti,

Rhizobium sp., Rhizobium meliloti,

Rhizobium loti, Sphingomonas

wittichii

1913
TKTRAEVRGGGR

Corynebacterium efficiens

Q8FS79
Q9BYD3

KP

1914
TLAIIKPDA

Haemophilus parasuis

B8F3E4
Q86XW9

1915
TLAIIKPDAV

Haemophilus somnus

Q0I2G6
Q86XW9

1916
TLGGTCLNVGC

Pseudomonas putida

P31046
P09622

1917
TLLFANAGM

Campylobacter jejuni

A1VYL8
P49588

1918
TLLGQNVNS

Clostridium botulinum, Clostridium

B1IM69, A7GE46,
Q96SZ6

botulinum, Clostridium botulinum,

BlKSA4, A5I2S3,

Clostridium botulinum, Clostridium

A7FUL1, Q895H1,

botulinum, Clostridium tetani,

Q8XLE9, Q0TRE5,

Clostridium perfringens, Clostridium

A000M5, Q0STS9,

perfringens, Clostridium novyi,

Q97I18, A3DDI9,

Clostridium perfringens, Clostridium

B2V276, B2TIA8,

acetobutylicum, Clostridium

B0S1C0, Q6A8Z7

thermocellum, Clostridium botulinum,

Clostridium botulinum, Finegoldia

magna, Propionibacterium acnes

1919
TLLGQNVNSF

Desulfovibrio vulgaris, Desulfovibrio

A1VF04, Q72DE5
Q96SZ6

vulgaris

1920
TLNFGPQHP

Clostridium beijerinckii

A6LXQ2
O75306

1921
TLNFGPQHPAAH

Ralstonia pickettii

B2U7Q8
O75306

GVLRLV

1922
TLVFDVELL

Escherichia coli, Escherichia coli,

P65765, P65764,
P62942

Escherichia coli

P45523

1923
TLVFEVELL

Escherichia coli

P0A9L3
P26885

1924
TLYHWDLPQ

Bacillus circulans, Paenibacillus

Q03506, P22505,
Q9UEF7

polymyxa, Bacillus subtilis

P42403

1925
TMLRVKDPK

Pseudomonas aeruginosa

Q9HU72
Q04760

1926
TMSTVGYGD

Escherichia coli

P31069
Q12791

1927
TMYGQMTAGS

Bacillus clausii, Streptomyces

Q5WCP7, Q9KZ75,
Q96N76

coelicolor, Streptomyces avermitilis,

Q82HL2, B1VUR5

Streptomyces griseus

1928
TNAGKSTLFN

Haemophilus somnus

Q0I442
Q8NC60

1929
TNASRTMLF

Clostridium phytofermentans

A9KQC2
Q14409

1930
TNASRTMLFNIH

Citrobacter koseri, Enterobacter sp.,
A8AL00, A4WG72,
Q14409

Escherichia coli, Escherichia coli,

B7NU81, B1LNM9,

Escherichia coli, Escherichia coli,

B7NFM3, P0A6F3,

Escherichia coli, Escherichia coli,

B1IVF3, Q0TAD8,

Escherichia coli, Escherichia coli,

A8A731, B1X1392,

Escherichia coli, Escherichia coli,

C5A093, P0A6F4,

Escherichia coli, Escherichia coli,

B5YZ64, B7MI58,

Escherichia coli, Escherichia coli,

B7LA23, A7ZUE0,

Escherichia fergusonii, Escherichia

B7LUS9, B7M6X7,

coli, Escherichia coli, Escherichia coli,

B7UNP6, B7N2R7,

Haemophilus influenzae,

P44400, A5UE44,

Haemophilus influenzae,

A5UHH7, Q4QMM7,

Haemophilus influenzae,

A6TFR2, B5XTD4,

Haemophilus influenzae, Klebsiella

Q87XL0, Q4ZPI7,

pneumoniae, Klebsiella pneumoniae,

Q48F01

Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas savastanoi

1931
TNASRTMLFNIHS

Escherichia coli

Q8FBC3
Q14409

L

1932
TNGSQFFITT

Streptomyces anulatus

Q06118
P30414

1933
TNGSQFFLT

Streptomyces anulatus

P77949
Q9UNP9

1934
TNPVDILTY

Bacillus methylotrophicus, Bacillus

A7Z152, P13714,
Q6ZMR3

subtilis, Bacillus

P14561, P20619,

psychrosaccharolyticus, Bacillus

A8F9Q8, Q65NP0,

psychrosaccharolyticus, Bacillus

Q8FLV6

pumilus, Bacillus licheniformis,

Corynebacterium efficiens

1935
TNVPGVFAAGD

Bacillus sp.
P26829
Q96NN9

1936
TPFYPRSPYG

Pseudomonas aeruginosa

Q51366
O60547

1937
TPGVAADLSHI

Proteus mirabilis

B4F2A1
P40926

1938
TPIINPPQSAILGM

Escherichia coli, Escherichia coli,

P0AFG6, P0AFG7,
P36957

H

Haemophilus influenzae

P45302

1939
TPIPHNGCRP

Acinetobacter baumannii,

B2HZ85, B0V6U5,
P82912

Acinetobacter baumannii,

B0VQU1, B7IA16,

Acinetobacter baumannii,

A3M961, B7GW25,

Acinetobacter baumannii,

Q6F7T5, A4SSY3,

Acinetobacter baumannii,

A0KF43, A5N4S3,

Acinetobacter baumannii,

B9DYD5, A6LPT8,

Acinetobacter baylyi, Aeromonas

B1KSJ8, A7GJ47,

salmonicida, Aeromonas hydrophila,

C1FMS4, A3DJJ9,

Clostridium kluyveri, Clostridium

A4WFA5, B7LRR4,

kluyveri, Clostridium beijerinckii,

Q1R635, B1LHB1,

Clostridium botulinum, Clostridium

B6I211, B7NDR9,

botulinum, Clostridium botulinum,

P0A7R9, 611Q02,

Clostridium thermocellum,

P0A7S0, Q0TCG4,

Enterobacter sp., Escherichia
A1AGI8, B7LHZ9,

fergusonii, Escherichia coli,

A8A5A2, B1X6E9,

Escherichia coli, Escherichia coli,

C4ZUF2, B7UK21,

Escherichia coli, Escherichia coli,

B7M103, B7N182,

Escherichia coli, Escherichia coli,

B7NLL7, B5YT16,

Escherichia coli, Escherichia coli,

P0A7S1, B7MCR3,

Escherichia coli, Escherichia coli,

A7ZSI6, Q39XY1,

Escherichia coli, Escherichia coli,

Q7VKF6, B8F6P8,

Escherichia coli, Escherichia coli,

Q0I139, A5UDS4,

Escherichia coli, Escherichia coli,

Q4QM99, P44379,

Escherichia coli, Escherichia coli,

A6TEV0, B4F1K7,

Escherichia coli, Escherichia coli,

B7V666, Q02T57,

Geobacter metallireducens,

A6UZL1, Q9HWF8,

Haemophilus ducreyi, Haemophilus

A4XZ67, A4VHQ3,

parasuis, Haemophilus somnus,

P59374, B1JAI9,

Haemophilus influenzae,

A5VXS0, Q1IFU3,

Haemophilus influenzae,

B0KK89, Q889U8,

Haemophilus influenzae, Klebsiella

Q4ZMR6, Q3K610,

pneumoniae, Proteus mirabilis,

C3K2V3, Q48D59,

Pseudomonas aeruginosa,

Q4K555, B2FQK6,

Pseudomonas aeruginosa,

B4SLH3

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas mendocina,

Pseudomonas stutzeri, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas putida, Pseudomonas

entomophila, Pseudomonas putida,

Pseudomonas syringae,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas fluorescens,

Pseudomonas savastanoi,

Pseudomonas fluorescens,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

1940
TPIPHNGCRPRK

Methylobacterium sp.,
B0UHU6, B8IT34,
P82912

Methylobacterium nodulans,

C3MB02, Q925W7,

Rhizobium sp., Rhizobium meliloti,
Q98N34, Q2K9J3,

Rhizobium loti, Rhizobium etli,

B5ZZ56, Q1M1B8,

Rhizobium leguminosarum,

B3PWU4

Rhizobium leguminosarum,

Rhizobium etli

1941
TPTPLGEGK

Propionibacterium acnes

Q6ABS5
P11586

1942
TPVFMPVGT

Acinetobacter baumannii,

A3M8S3, B0V625,
Q9BXR0

Acinetobacter baumannii,

B7I976, B7GWL4,

Acinetobacter baumannii,

B2HYN7, Q6FEJ4,

Acinetobacter baumannii,

O32053, A7Z766,

Acinetobacter baumannii,

Q65GP9, A8FFQ9,

Acinetobacter baylyi, Bacillus subtilis,

A7ZD89, A1VZZ8,

Bacillus methylotrophicus, Bacillus

Q5HUF2, A8FM59,

licheniformis, Bacillus pumilus,

Q9PNT0, A7H331,

Campylobacter concisus,

B8I6M0, Q9JVA4,

Campylobacter jejuni, Campylobacter

Q5F9U5, A1KSY1,

jejuni, Campylobacter jejuni,

B4RJY2, A9M374,

Campylobacter jejuni, Campylobacter

Q9K096

jejuni, Clostridium cellulolyticum,

Neisseria meningitidis, Neisseria

gonorrhoeae, Neisseria meningitidis,

Neisseria gonorrhoeae, Neisseria

meningitidis, Neisseria meningitidis

1943
TPVFMPVGTQ

Arcobacter butzleri, Desulfovibrio

A8ERD1, C4XSI9,
Q9BXR0

maeticus, Helicobacter pylori,

Q9ZMF4, Q7VHX2

Helicobacter hepaticus

1944
TPVFMPVGTQAT

Desulfitobacterium hafniense,

B8FQV2, Q8RDN0
Q9BXR0

Fusobacterium nucleatum

1945
TPVPGGVGPMT

Arcobacter butzleri, Bacillus

A8ESH8, Q9K966,
P13995

halodurans, Desulfovibrio maeticus,

C4XLR8, C6BSL6,

Desulfovibrio salexigens,

B8DMA9, Q6W210

Desulfovibrio vulgaris, Rhizobium sp.

1946
TQGKGLMPD

Haemophilus influenzae

P44557
P11766

1947
TQGKGLMPDGT

Escherichia coli, Escherichia coli,

B1J085, A7ZX04,
P11766

Escherichia coli, Escherichia coli,

Q8X5J4, A7ZIA4,

Escherichia coli, Escherichia coli,

Q1RFI7, P25437,

Escherichia coli, Escherichia coli,

Q0TKS7, A1A835,

Escherichia coli, Escherichia coli

Q8FKG1, B1LIP1

1948
TQIPILTMP

Enterococcus hirae, Enterococcus

Q08637, Q834X8
P15313

faecalis

1949
TQKCIRAGGKHND

Akkermansia muciniphila

B2UKT4
P49588

L

1950
TQNVDALHT

Pseudomonas syringae

Q882K4
Q9Y6E7

1951
TRLTESGLS

Rhizobium meliloti, Rhizobium sp.,
Q92QR8, C3MA28,
Q7KZN9

Rhizobium loti, Sphingomonas

Q982X5, A5VF68

wittichii

1952
TRVGGIPEV

Bacillus anthracis

Q81ST7
P37287

1953
TSGATESNN

Pseudomonas syringae,

Q4ZX34, Q48M05,
Q9Y697

Pseudomonas savastanoi,

Q887A1

Pseudomonas syringae

1954
TSGSTGKPK

Bacillus subtilis

O07619
Q9NR19

1955
TSGSTGKPKGV

Bacillus licheniformis

O68006
Q9NR19

1956
TSGSTGLPK

Escherichia coli

P37353
O95573

1957
TSGSTGRPKGVM

Escherichia coli, Escherichia coli

P11454, Q8XBV9
O60488

1958
TSGTTGFPK

Bacillus subtilis

O31826
P0C7M7

1959
TSGTTGLPK

Staphylococcus haemolyticus,

Q4L3Q0, Q9KWK5,
Q9H6R3

Staphylococcus aureus,

Q5HIA1, Q7A1Q0,

Staphylococcus aureus,

Q7A769, Q6GBR2,

Staphylococcus aureus,

Q99W34, Q6GJ94,

Staphylococcus aureus,

Q8CQ67, Q5HRH4

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

1960
TSGTTGLPKGV

Streptococcus agalactiae,

Q8VM67, P59591,
Q9H6R3

Streptococcus agalactiae,

Q3JZ94

Streptococcus agalactiae

1961
TSGTTGNPK

Bacillus subtilis

P96575
Q96GR2

1962
TSVLKRAIRTL

Desulfovibrio alaskensis

Q30WZ8
P15259

1963
TTRSPREGEV

Bacillus subtilis

O34328
Q96QZ7

1964
TTTTHKTLRG

Lactobacillus salivarius, Eubacterium

Q1WTR3, C4ZH69,
P34897

rectale, Methylobacterium

B1LZ88, C1C6Z9,

radiotolerans, Streptococcus

Q97R16, B1IB13,

pneumoniae, Streptococcus

C1CRE4, Q8DPZ0,

pneumoniae, Streptococcus

Q04KR0, C1CKA2,

pneumoniae, Streptococcus

A4VUM9, A4W0W9,

pneumoniae, Streptococcus

C1QE16, B2IPI0,

pneumoniae, Streptococcus

B8ZPH5, B5E4E3

pneumoniae, Streptococcus

pneumoniae, Streptococcus suis,

Streptococcus suis, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae

1965
TTVVADTGD

Aeromonas salmonicida, Edwardsiella

A45K74, C5B7L0,
P37837

ictaluri, Escherichia coli, Escherichia

Q8FLD1, KOBE10,

coli, Escherichia coli, Escherichia coli,

P0A870, P0A871,

Proteus mirabilis, Rhizobium etli,

B4F2V2, Q2K414,

Rhizobium etli, Rhizobium

B3Q0T5, B5ZQY2

leguminosarum

1966
TTVVADTGDF

Pseudomonas fluorescens,

Q4KF90, B7UWP0,
P37837

Pseudomonas aeruginosa,

Q9I047, Q02NV3,

Pseudomonas aeruginosa,

A6V3U3

Pseudomonas aeruginosa,

Pseudomonas aeruginosa

1967
TVIGGGDTA

Campylobacter lari

B9KFD9
P07205

1968
TVLIMELINN

Fusobacterium nucleatum

Q8RGE2
P06576

1969
TVPAYFNDA

Bacillus methylotrophicus, Bacillus

A7Z6W1, P17820,
P11021

subtilis, Clostridium perfringens,

Q0SRE3, P26823,

Clostridium perfringens, Clostridium

Q0TNS7, O33528,

perfringens, Rhizobium

Q4L6T0, B9DNK0,

leguminosarum, Staphylococcus

A8Z4B9, P64408,

haemolyticus, Staphylococcus

Q5HFI0, Q6G8Y7,

carnosus, Staphylococcus aureus,

Q6GGC0, P99110,

Staphylococcus aureus,

P64407, A6QHC3,

Staphylococcus aureus,

Q2FXZ2, A5ITA8,

Staphylococcus aureus,

A6U252, Q2FGE3,

Staphylococcus aureus,

A7X2Y1, P45554,

Staphylococcus aureus,

Q2YT47

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1970
TVPAYFNDAQR

Akkermansia muciniphila, Arcobacter

B2UKV6, A8EWT6,
P11021

butzleri, Campylobacter jejuni,

O69298, Q5HV33,

Campylobacter jejuni, Campylobacter

A8FLH2, B9KCH0,

jejuni, Campylobacter lari,

A7H484

Campylobacter jejuni

1971
TVPAYFNDAQRQ

Porphyromonas gingivalis,

P0C937, B2RJ90
P11021

ATK

Porphyromonas gingivalis

1972
TVPAYFNDAQRQ

Acinetobacter baumannii,

A3M8W9, B2HZZ7,
P11021

ATKDAG

Acinetobacter baumannii,

B0V5U4, B7IBK5,

Acinetobacter baumannii,

B7H317, Q6F6N3,

Acinetobacter baumannii,

A0KMI6, A4SQ25,

Acinetobacter baumannii,

P71331, B2GBQ5,

Acinetobacter baylyi, Aeromonas

B0UR84, A8ALU3,

hydrophila, Aeromonas salmonicida,

A9KKU0, C4XQ63,

Aggregatibacter

B8DRD6, A1VFG6,

actinomycetemcomitans,

Q72DW8, B8J402,

Lactobacillus fermentum,

C5B7L7, A4W6D5,

Methylobacterium sp., Citrobacter
A7ZW7, Q1RG18,

koseri, Clostridium phytofermentans,

P0A6Y8, B1IRG0,

Desulfovibrio maeticus, Desulfovibrio

P0A6Y9, Q0TLX5,

vulgaris, Desulfovibrio vulgaris,

A1A766, P0A6Z0,

Desulfovibrio vulgaris, Desulfovibrio

A7ZHA4, Q0I3V2,

desulfuricans, Edwardsiella ictaluri,

P48209, A6T4F4,

Enterobacter sp., Escherichia coli,
B5Y242, B8IHL3,

Escherichia coli, Escherichia coli,

B7KSZ4, A9W6R7,

Escherichia coli, Escherichia coli,

B1ZGR1, B1LZ51,

Escherichia coli, Escherichia coli,

B4F2V5, P42374,

Escherichia coli, Escherichia coli,

B3PXH3, Q2KDW6,

Haemophilus somnus, Haemophilus

Q1MN11, B5ZWQ2,

ducreyi, Klebsiella pneumoniae,

A5V5P9

Klebsiella pneumoniae,

Methylobacterium nodulans,

Methylobacterium extorquens,

Methylobacterium extorquens,

Methylobacterium populi,

Methylobacterium radiotolerans,

Proteus mirabilis, Rhizobium meliloti,

Rhizobium etli, Rhizobium etli,

Rhizobium leguminosarum,

Rhizobium leguminosarum,

Sphingomonas wittichii

1973
TWRLNERHYG

Lactobacillus johnsonii, Lactobacillus

Q74LL9, Q88T35,
P15259

plantarum, Lactobacillus acidophilus,

Q5FMJ3, Q88YY8,

Lactobacillus plantarum, Lactobacillus

Q74L45, A9M1A2,

johnsonii, Neisseria meningitidis,

B4RIY7, Q5F7CQ3

Neisseria gonorrhoeae, Neisseria

Q9JYF7, A1KV25,

gonorrhoeae, Neisseria meningitidis,

Q9JTF2

Neisseria meningitidis, Neisseria

meningitidis

1974
TYGCQMNVN

Fusobacterium nucleatum

Q8RG43
Q96SZ6

1975
TYGGNPLGC

Pseudomonas putida

P59319
P04181

1976
TYGTGCFLL

Clostridium tetani

Q893Q3
Q14409

1977
TYNKDLQEDKE

Streptococcus suis, Streptococcus

A4VXZ3, A4W487
P04424

suis

1978
TYPLIGNYG

Akkermansia muciniphila,

B2URJ0, Q8KZA0,
P27708

Desulfovibrio vulgaris, Desulfovibrio

B8IZ56

desulfuricans

1979
TYPLIGNYGI

Bacillus halodurans, Bacillus cereus,

Q9K8V6, Q819S2,
P27708

Bacillus thuringiensis, Bacillus

Q6HES7, Q81WF1,

anthracis, Bacillus cereus, Bacillus

Q636D9, Q732I2,

cereus, Bacillus caldolyticus,

P52557, P77885,

Lactobacillus plantarum, Bacillus

P36838, O08317,

subtilis, Lactobacillus plantarum,

Q8XHB2, C6C0A9,

Clostridium perfringens, Desulfovibrio

Q5HPY9, Q49WY3,

salexigens, Staphylococcus

Q4L5Q4, Q8CPJ5,

epidermidis, Staphylococcus

P99147, P63730,

saprophyticus, Staphylococcus

Q5HGN0, P63729,

haemolyticus, Staphylococcus

Q6GA11, Q6GHN3,

epidermidis, Staphylococcus aureus,

P0DA13, P63735,

Staphylococcus aureus,

Q5XCR8, P0DA12,

Staphylococcus aureus,

P58894, P63731,

Staphylococcus aureus,

P63732

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus agalactiae

1980
VAAGGRYDGL

Geobacter metallireducens,

Q39UD2, P60915
P12081

Geobacter sulfurreducens

1981
VAAGGRYDGLV

Geobacter lovleyi

B3EB83
P12081

1982
VAGETGSGK

Escherichia coli

P43329
Q7Z478

1983
VAGGMENMS

Escherichia coli

P76461
Q9BWD1

1984
VALLSGGGSGHE

Escherichia coli

P76015
Q3LXA3

P

1985
VAMVGDGIND

Escherichia coli, Escherichia coli,

Q8XD24, Q59385,
Q04656

Haemophilus influenzae, Listeria

P77868, Q60048

monocytogenes

1986
VAPGNAGTA

Escherichia coli, Escherichia coli,

P15640, Q8X612,
P22102

Escherichia coli, Haemophilus

Q8FB69, P43845,

influenzae, Neisseria meningitidis,

Q9JXA3, Q9JWU6

Neisseria meningitidis

1987
VASEIMAVL

Bacillus licheniformis, Eubacterium

Q65IA6, C4Z1V6
P11586

eligens

1988
VASYPFTTL

Akkermansia muciniphila

B2UQ30
Q9H4K7

1989
VATPVFMPVGTQ

Helicobacter pylori, Helicobacter

B2USB2, O08314,
Q9BXR0

pylori, Helicobacter pylori,

B5ZA47, Q1CUM2,

Helicobacter pylori, Helicobacter

B6JKL0

pylori

1990
VAVYNHYKRI

Kocuria rhizophila

B2GGB7
O76031

1991
VDAIVNAAN

Lactobacillus plantarum, Citrobacter

Q885K6, D2TT52,
A1Z1Q3

rodentium, Pseudomonas aeruginosa,

Q9HXU7, Q985D2,

Rhizobium loti, Streptococcus

Q8P0X2, P0DC29,

pyogenes, Streptococcus pyogenes,

P0DC28, Q5XC09,

Streptococcus pyogenes,

Q99ZI6

Streptococcus pyogenes,

Streptococcus pyogenes

1992
VDDLLATGGT

Desulfitobacterium hafniense,

Q24UQ1, B8FQU0,
P07741

Desulfitobacterium hafniense,

A3DF48, A7GHS8,

Clostridium thermocellum, Clostridium

A7FY09, A5I6E1,

botulinum, Clostridium botulinum,

B1IME3, B1L0A2,

Clostridium botulinum, Clostridium

Q0TP22, Q8XJ22,

botulinum, Clostridium botulinum,

Q0SRP2, B2TMZ9,

Clostridium perfringens, Clostridium

B2V345, A5N1Z4,

perfringens, Clostridium perfringens,

B9E5P8, B8I3F7,

Clostridium botulinum, Clostridium

Q97GU0, C5BCZ7,

botulinum, Clostridium kluyveri,

B0S0M3, Q9ZLQ9,

Clostridium kluyveri, Clostridium

Q03W57, B1MZQ2,

cellulolyticum, Clostridium

B4EU76, C1CSJ8,

acetobutylicum, Edwardsiella ictaluri,

A4W292, A4VVY4,

Finegoldia magna, Helicobacter

A3CNR3, A8AWY0,

pylori, Leuconostoc mesenteroides,

P63544, P63545,

Leuconostoc citreum, Proteus

C1CLS6, B1ICZ7,

mirabilis, Streptococcus pneumoniae,

B8ZLT9, C1C8G8,

Streptococcus suis, Streptococcus

Q04JH1, B5E6M0,

suis, Streptococcus sanguinis,

B9DUP2, A2REX9,

Streptococcus gordonii,

P0CZ63, Q48TY5,

Streptococcus pneumoniae,

B5XL39, Q1J702,

Streptococcus pneumoniae,

P63546, Q1JM38,

Streptococcus pneumoniae,

P0CZ62, Q1JC56,

Streptococcus pneumoniae,

Q5XCH4, Q1JH84,

Streptococcus pneumoniae,

P63548, Q03K92,

Streptococcus pneumoniae,

Q5M3Y6, Q5LZD4,

Streptococcus pneumoniae,

Q8DT95

Streptococcus pneumoniae,

Streptococcus uberis, Streptococcus

pyogenes, Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus thermophilus,

Streptococcus mutans

1993
VDDLLATGGTM

ptoclostridium difficile

Q183I0
P07741

1994
VDDLLATGGTMN

Clostridium novyi

A0PZW4
P07741

1995
VDGKDVMPEVN

Haemophilus somnus

Q0I3C7
P06744

1996
VDILVNNAG

Escherichia coli, Escherichia coli,

P0AET8, P0AET9,
Q6IAN0

Streptomyces violaceoruber

P16542

1997
VDILVNNAGI

Escherichia coli, Rhizobium meliloti,

P76633, P06234,
Q6IAN0

Rhizobium meliloti

P50205

1998
VDKHSTGGVGD

Aeromonas hydrophila, Aeromonas

A0KPE3, A4SRU3,
P19971

salmonicida, Bacillus subtilis,

P39142, A4W699,

Enterobacter sp., Escherichia coli,
B7UR10, B1IS37,

Escherichia coli, Escherichia coli,

B6I6M9, B1LEI7,

Escherichia coli, Escherichia coli,

B7NH50, Q8FA52,

Escherichia coli, Escherichia coli,

B7LXU4, B7NW62,

Escherichia coli, Escherichia coli,

B5Z4R4, Q8X1335,

Escherichia coli, Escherichia coli,

A7ZVS5, A8A8B1,

Escherichia coli, Escherichia coli,

B7LEM8, P07650,

Escherichia coli, Escherichia coli,

B1XFJ2, B7MNI9,

Escherichia coli, Escherichia

B7LNS2, B7MTC8,

fergusonii, Escherichia coli, Klebsiella

A6THZ7, B5Y276,

pneumoniae, Klebsiella pneumoniae,

B4EWA3, C3MBH0,

Proteus mirabilis, Rhizobium sp.,
Q92T50, Q5HM85,

Rhizobium meliloti, Staphylococcus

Q4L818, Q8CNH8,

epidermidis, Staphylococcus

Q5HE64, Q2FWC1,

haemolyticus, Staphylococcus

Q2FEZ3, Q6GET9,

epidermidis, Staphylococcus aureus,

Q6G7H4, Q8NVF6,

Staphylococcus aureus,

Q7A4D0, Q99SC3,

Staphylococcus aureus,

Q2YUL7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

1999
VDPLDGTKE

Escherichia coli, Escherichia coli,

Q8XCG6, Q8FAG5,
Q95861

Escherichia coli

P22255

2000
VDQETGEDL

Methylobacterium extorquens,

A9W8P8, B7KN55
Q14562

Methylobacterium extorquens

2001
VDQHAAHER

Rhizobium etli, Rhizobium meliloti,

Q2KBX7, Q92RP4,
Q9UHC1

Rhizobium leguminosarum,

B5ZSQ0, Q1MKU7,

Rhizobium leguminosarum,

B3PRD9, Q983L2,

Rhizobium etli, Rhizobium loti,

C3MGW0

Rhizobium sp.

2002
VDTWWQTETGGI

Aeromonas hydrophila, Aeromonas

A0KNI2, A4SJM6
Q9NUB1

salmonicida

2003
VDVLVNNAG

Streptomyces coelicolor

P16544
Q9NYR8

2004
VDVNVHPTK

Lactobacillus salivarius, Lactobacillus

Q1WT16, Q03R34,
P40692

brevis, Lactobacillus plantarum,

Q88UZ8, Q97I20,

Clostridium acetobutylicum, Neisseria

Q9JT52, A1KUP6,

meningitidis, Neisseria meningitidis,

A9M0G1, Q5F8M6,

Neisseria meningitidis, Neisseria

B4RLX4, Q9JYT2,

gonorrhoeae, Neisseria gonorrhoeae,

Q03EQ8

Neisseria meningitidis, Pediococcus

ntosaceus

2005
VDVNVHPTKHEV

Geobacter bemidjiensis, Geobacter

B5EGD4, C6E4L2,
P40692

sp., Geobacter sulfurreducens,
Q74BP0, B3E5Z2,

Geobacter lovleyi, Geobacter daltonii,

B9M3N0, A5GEV5

Geobacter uraniireducens

2006
VEFSRNVLG

Staphylococcus aureus,

Q2FWD1, Q6GEU8,
P17812

Staphylococcus aureus,

Q2YUM6, A8YY92,

Staphylococcus aureus,

Q5HE73, Q6G7I3,

Staphylococcus aureus,

A6Q1X1, P65923,

Staphylococcus aureus,

A5IU52, P65924,

Staphylococcus aureus,

A6U3L2, P99072,

Staphylococcus aureus,

Q2FF01, A7X4X7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

2007
VEGDSAFGFSGM

Oxalobacter formigenes

P40149
Q9UJ83

E

2008
VEIAGPGFIN

Geobacter sulfurreducens, Listeria

Q74C63, A0ALP7,
P54136

welshimeri, Listeria monocytogenes,

B8DBE8, Q71WL8,

Listeria monocytogenes, Listeria

Q8Y493, Q927T2,

monocytogenes, Listeria innocua,

C1KYX7

Listeria monocytogenes

2009
VEIAGPGFINV

Desulfovibrio alaskensis

Q30Z04
P54136

2010
VELCGALKN

Lactobacillus delbrueckii

Q1G8H5
Q8N335

2011
VELNRKVLADLA

Desulfovibrio vulgaris, Desulfovibrio

Q728R8, A1VBB7
Q9BYC9

vulgaris

2012
VEPIQGEAG

Staphylococcus aureus,

P60299, Q6GAW9,
P04181

Staphylococcus aureus,

P60297, P60298,

Staphylococcus aureus,

Q5HHC8, Q6GID1,

Staphylococcus aureus,

Q8CT82, Q5HQK4,

Staphylococcus aureus,

B9DIU0

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus carnosus

2013
VEVGPRDGLQNE

Pseudomonas aeruginosa

Q9I2A0
Q8TB92

K

2014
VEVNCETDFV

Clostridium kluyveri, Clostridium

A5N829, B9EI19,
P43897

kluyveri, Clostridium tetani

Q895L1

2015
VFDLGGGTFD

Bacteroides vulgatus, Bacteroides

A6L2X7, Q64X01,
P11021

fragilis, Bacteroides fragilis,

Q5LG30, A6LDG8,

Parabacteroides distasonis,

Q89YW6, Q93GF1

Bacteroides thetaiotaomicron,

Prevotella loescheii

2016
VFTFGPTFRAE

Lactobacillus plantarum, Bacillus

Q88WA8, Q5WGB1,
Q96I59

clausii, Enterococcus faecalis

Q831X4

2017
VGAGSAGCVLA

Pseudomonas putida, Pseudomonas

Q9WWW2, Q00593
Q8NE62

oleovorans

2018
VGASGDLAPL

Methylobacterium sp., Citrobacter
B0UQ15, A8AJ15,
P42357

koseri, Enterobacter sp., Klebsiella
A4W8B5, B5XZ79,

pneumoniae, Klebsiella pneumoniae,

A6T6L1, B8II08,

Methylobacterium nodulans,

Q87UM1, Q3KJE6,

Pseudomonas syringae,

Q8VMR3, P21310,

Pseudomonas fluorescens,

Q88CZ7, Q02ER8,

Pseudomonas fluorescens,

Q9HU85, B7V3J1,

Pseudomonas putida, Pseudomonas

Q8XW29, O31197

putida, Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa, Ralstonia

solanacearum, Rhizobium meliloti

2019
VGASGDLAPLSH

Rhizobium loti

Q983I0
P42357

2020
VGDEGGFAPN

Acinetobacter baylyi, Acinetobacter

Q6FAT9, B0V677,
P06733

baumannii, Acinetobacter baumannii,

B212A5, B71918,

Acinetobacter baumannii,

A3M5Y1, B7H227,

Acinetobacter baumannii,

B0VQI4, Q97L52

Acinetobacter baumannii,

Acinetobacter baumannii, Clostridium

acetobutylicum

2021
VGDVRGKGL

Bacillus subtilis

P33189
Q9BYV1

2022
VGFPSVGKST

Streptococcus thermophilus,

Q03JJ8, Q5M3C8,
Q9Y295

Streptococcus thermophilus,

Q5LYR4

Streptococcus thermophilus

2023
VGFPSVGKSTLLS

Bacillus halodurans, Bacillus

Q9KDK0, Q65GM7,
09Y295

licheniformis, Bacillus pumilus,

A8FFS8, Q5WHS8,

Bacillus clausii, Lactobacillus sakei,

Q38WI4, A7Z781,

Bacillus methylotrophicus, Bacillus

A9VIR5, B7IIV2,

weihenstephanensis, Bacillus cereus,

P20964, Q72ZY5,

Bacillus subtilis, Bacillus cereus,

Q6HD85, Q634A3,

Bacillus thuringiensis, Bacillus cereus,

C1ETN7, AQRJ47,

Bacillus cereus, Bacillus thuringiensis,

B7HQJ8, Q817U6,

Bacillus cereus, Bacillus cereus,

B9IZ16, B7JQ26,

Bacillus cereus, Bacillus cereus,

Q81LF0, B7HE73,

Bacillus anthracis, Bacillus cereus,

Q88VG4, A8YV14,

Lactobacillus plantarum, Lactobacillus

Q03QP2, Q043W1,

helveticus, Lactobacillus brevis,

Q5FKH5, Q74JN7,

Lactobacillus gasseri, Lactobacillus

Q1WT46, B3WE52,

acidophilus, Lactobacillus johnsonii,

Q039J3, Q834V4,

Lactobacillus salivarius, Lactobacillus

A0A1Y6, Q92BH7,

casei, Lactobacillus casei,

B8DHL1, Q71ZD3,

Enterococcus faecalis, Listeria

Q8Y6Z3, B9DNE7,

welshimeri, Listeria innocua, Listeria

Q8CNZ7, Q5HNQ7,

monocytogenes, Listeria

Q5HFB9, Q7A003,

monocytogenes, Listeria

A6QHI6, A8Z2H2,

monocytogenes, Staphylococcus

Q6G8S5, Q7A584,

carnosus, Staphylococcus

Q99TK9, A5ITG8,

epidermidis, Staphylococcus

Q2FXT1, Q2FG83,

epidermidis, Staphylococcus aureus,

A7X361, A6U2B2,

Staphylococcus aureus,

Q6GG60, Q2YT86,

Staphylococcus aureus,

Q49Y82, Q4L6Y9,

Staphylococcus aureus,

A4VUC8, A4W0M2,

Staphylococcus aureus,

Q8DYL0, Q8E465,

Staphylococcus aureus,

Q3K046, P0DB53,

Staphylococcus aureus,

P0DB52, Q1JLA1,

Staphylococcus aureus,

Q1JBB7, Q99Z94,

Staphylococcus aureus,

Q48SX8, Q8P0I6,

Staphylococcus aureus,

Q5XBM1, B5XLZ0,

Staphylococcus aureus,

Q1JGD5, Q1J652,

Staphylococcus aureus,

A2RE30, Q8DPV8,

Staphylococcus aureus,

Q04KK7, Q97QW8,

Staphylococcus aureus,

B5E4J4, B2IQ29,

Staphylococcus saprophyticus,

B1IBL9, B9DSH7,

Staphylococcus haemolyticus,

B8ZPS8, B4U3Q7,

Streptococcus suis, Streptococcus

A3CM33, C0MDB4,

suis, Streptococcus agalactiae,

C0MBS1, A8AWM9,

Streptococcus agalactiae,

Q8DUU2

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus uberis, Streptococcus

pneumoniae, Streptococcus equi,

Streptococcus sanguinis,

Streptococcus equi, Streptococcus

equi, Streptococcus gordonii,

Streptococcus mutans

2024
VGGIRASLYNA

Stenotrophomonas maltophilia,

B45P45, B2FKF0
Q9Y617

Stenotrophomonas maltophilia

2025
VGGRYSLWS

Sphingomonas wittichii

A5V9W3
P06744

2026
VGICGSDVH

Escherichia coli

P77280
Q00796

2027
VGICGSDVHY

Morganella morganii

Q59545
Q00796

2028
VGINGFGRIGR

Bacillus subtilis, Bacillus coagulans,

P09124, P15115,
O14556

Bacteroides fragilis, Corynebacterium

Q59199, Q01651,

glutamicum, Escherichia fergusonii,

B7LQ20, P0A9B3,

Escherichia coli, Escherichia coli,

P0A9B2, P0A9B4,

Escherichia coli, Streptomyces

Q829W3, Q9Z518,

avermitilis, Streptomyces coelicolor,

Q82IZ2

Streptomyces avermitilis

2029
VGINGFGRIGRL

Streptococcus pyogenes,

P0COG6, Q5XDW3,
O14556

Streptococcus pyogenes,

P68777, P0COG7,

Streptococcus pyogenes,

P0DB19, P0DB18,

Streptococcus pyogenes,

Q59906

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus dysgalactiae

2030
VGINGFGRIGRLV

Escherichia coli

P33898
O14556

L

2031
VGINGFGRIGRLV

Escherichia coli

P58072
O14556

LR

2032
VGKGITFDSGG

Citrobacter koseri, Escherichia

A8AD60, B7LKB6,
P28838

fergusonii, Escherichia coli,

B5Z0Z6, P58473,

Escherichia coli, Escherichia coli,

B1IWD8, A8A329,

Escherichia coli, Escherichia coli,

P37095, B1XAZ8,

Escherichia coli, Escherichia coli,

C4ZX98, Q8FF47,

Escherichia coli, Escherichia coli,

Q0TEW2, B7MYF7,

Escherichia coli, Escherichia coli,

B7UGW9, Q1R8K9,

Escherichia coli, Escherichia coli,

A1AE61, B7MI07,

Escherichia coli, Escherichia coli,

A7ZPW6, B6I595,

Escherichia coli, Escherichia coli,

B7M7M6, B7LDB5,

Escherichia coli, Escherichia coli,

B1LNH8, B7N6B0,

Escherichia coli, Escherichia coli,

B7NRH2, Q4QM33,

Haemophilus influenzae,

P58474, A6TCE4,

Haemophilus influenzae, Klebsiella

B5XNK4, Q6A9W5

pneumoniae, Klebsiella pneumoniae,

Propionibacterium acnes

2033
VGKGITFDSGGIS

Geobacter sulfurreducens

Q74GB4
P28838

2034
VGKGITFDSGGISI

Geobacter sp.
C6E543
P28838

K

2035
VGKSSFINKV

Fusobacterium nucleatum

Q8RHS8
Q9BZE4

2036
VGLGNIWRFPY

Haemophilus influenzae

P44849
Q9H1V8

2037
VGLPAKSGV

Citrobacter koseri, Enterobacter sp.,
A8AGR2, A4WAF3,
O94925

Escherichia coli, Escherichia coli,

P0A6W0, P0A6W1,

Escherichia coli, Klebsiella

P0A6W2, A6T8Z6,

pneumoniae, Klebsiella pneumoniae,

B5XQU9, Q8XQS6

Ralstonia solanacearum

2038
VGLTGGIASGK

Haemophilus ducreyi

Q7VM70
Q8WVC6

2039
VGLTGGIASGKS

Propionibacterium acnes

Q6A9M5
Q8WVC6

2040
VGRLKTGTP

Arcobacter butzleri, Geobacter

A8EWV0, Q74604,
09Y2Z2

sulfurreducens, Geobacter

A5G9V2, Q39PR0

uraniireducens, Geobacter

metallireducens

2041
VGRLKTGTPPRI

Acinetobacter baumannii,

B0V7I0, B7IC15,
Q9Y2Z2

Acinetobacter baumannii,

B7H0I9, A3M6R5,

Acinetobacter baumannii,

B2HUB2, B0VLL2,

Acinetobacter baumannii,

Q6F9Q1, B7UMK6,

Acinetobacter baumannii,

B6I3X8, B7NF57,

Acinetobacter baumannii,

P0A6U3, B1IWZ7,

Acinetobacter baylyi, Escherichia coli,

P0A6U4, B7NR43,

Escherichia coli, Escherichia coli,

Q0TAW8, A8A6K4,

Escherichia coli, Escherichia coli,

B1X9W9, B7N2I0,

Escherichia coli, Escherichia coli,

C4ZZ19, B7M597,

Escherichia coli, Escherichia coli,

B7L889, A7ZTV2,

Escherichia coli, Escherichia coli,

Q1R4J1, A1AHS1,

Escherichia coli, Escherichia coli,

B7MGG1, B5YXE5,

Escherichia coli, Escherichia coli,

Q8XAY0, B1LL68,

Escherichia coli, Escherichia coli,

B4F0D8, Q88RW8,

Escherichia coli, Escherichia coli,

Q87TS3, Q9F5X1,

Escherichia coli, Escherichia coli,

P25756, Q48BF4,

Proteus mirabilis, Pseudomonas

A5WBB4, A4VS73,

putida, Pseudomonas syringae,

B0KRB9, B1JFV2,

Pseudomonas syringae,

Q4K399, A6VF43,

Pseudomonas putida, Pseudomonas

Q9HT09, B7V7A2,

savastanoi, Pseudomonas putida,

Q02DE3, A4Y198,

Pseudomonas stutzeri, Pseudomonas

Q3K430, Q1I2H6

putida, Pseudomonas putida,

Pseudomonas fluorescens,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas mendocina,

Pseudomonas fluorescens,

Pseudomonas entomophila

2042
VGRNIIHGSDS

Staphylococcus aureus,

A7X2H3, P99068,
O60361

Staphylococcus aureus,

A60H18, Q2FGX3,

Staphylococcus aureus,

A5ISZ7, Q2FYG7,

Staphylococcus aureus,

A6U1T7, Q5HFV4,

Staphylococcus aureus,

Q6GGU2, P68870,

Staphylococcus aureus,

Q2YY87, P68869,

Staphylococcus aureus,

A8Z448, Q6G994,

Staphylococcus aureus,

Q8NWN1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

2043
VGTDSHTTM

Corynebacterium jeikeium

Q4JVM4
P21399

2044
VGTGGTITG

Neisseria meningitidis

Q7DDL5
P35520

2045
VGTSSLRRA

Fusobacterium nucleatum

Q8RFP5
P08397

2046
VGTSSLRRAAQL

Listeria welshimeri

A0AJO5
P08397

2047
VHAENGELV

Pseudomonas aeruginosa,

Q9I676, Q59699
Q9BPU6

Pseudomonas putida

2048
VHRDIKPGN

Corynebacterium glutamicum,

Q8NU97, Q8FUI4,
Q14164

Corynebacterium efficiens,

Q9S2C0

Streptomyces coelicolor

2049
VHRDLKPAN

Streptomyces coelicolor

P54739
Q8IZL9

2050
VHRDLKPQNIL

Streptococcus pneumoniae,

Q8DNS0, Q04J43,
000534

Streptococcus pneumoniae,

Q97PA9, Q8KY50

Streptococcus pneumoniae,

Streptococcus pneumoniae

2051
VHRDLKPSN

Streptomyces coelicolor,

P54741, P54742
Q15418

Streptomyces griseus

2052
VHSLKDLPT

Streptomyces coelicolor,

Q9WX16, Q82E76
P08397

Streptomyces avermitilis

2053
VHSLKDLPTVLPP

Desulfitobacterium hafniense,

Q24VC8, B8G2M2
P08397

G

Desulfitobacterium hafniense

2054
VIAHRLSTI

Bacillus subtilis, Escherichia coli,

Q07549, P0AAG5,
Q9NRK6

Escherichia coli, Escherichia coli

P0AAG6, P0AAG7

2055
VIAHRLSTV

Bacillus subtilis

O06967
Q9NUT2

2056
VIGAWDVQF

Rhizobium loti

Q98EV8
P06576

2057
VIGKGGETI

Enterococcus faecalis, Streptococcus

Q82ZJ2, Q8DW32,
Q96AE4

mutans, Streptococcus equi,

C0M913, C0MFB1,

Streptococcus equi, Streptococcus

B4U573, Q5M6F9,

equi, Streptococcus thermophilus,

Q5M1W9, B9DTE3,

Streptococcus thermophilus,

Q03MV9, A8AV53,

Streptococcus uberis, Streptococcus

A3CQG6, C1C076,

thermophilus, Streptococcus gordonii,

B8ZMC0, C1C5V9,

Streptococcus sanguinis,

Q8DQT0, Q04LT4,

Streptococcus pneumoniae,

B2IMQ9, B5E2A0,

Streptococcus pneumoniae,

C1CCVV4, B1IAA9,

Streptococcus pneumoniae,

Q97S28, A4VXQ4,

Streptococcus pneumoniae,

A4W401, Q8E1Z8,

Streptococcus pneumoniae,

Q3K3G9, Q8E7F6,

Streptococcus pneumoniae,

Q1J9S6, Q5X9W0,

Streptococcus pneumoniae,

Q1JJX5, Q48RA2,

Streptococcus pneumoniae,

Q1JEW6, P0DD13,

Streptococcus pneumoniae,

P0DD12, A2RGH2,

Streptococcus pneumoniae,

Q1J4N2, B5XIK4,

Streptococcus suis, Streptococcus

Q8NZC6, Q99XZ5

suis, Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes

2058
VIHFAGLKAVGES

Bifidobacterium longum, Neisseria

E8MF10, P56985,
Q14376

V

meningitidis, Neisseria meningitidis,

P56997, Q05026,

Neisseria gonorrhoeae, Neisseria

P56986

meningitidis

2059
VIHFAGLKAVGES

Escherichia coli

P09147
Q14376

VQKPL

2060
VILDEPTAG

Staphylococcus saprophyticus

Q49ZD9
O95477

2061
VILGQDPYH

Campylobacter jejuni

A7H1G3
P13051

2062
VILGQDPYHG

Neisseria meningitidis, Neisseria

A1KU26, Q9JZA1,
P13051

meningitidis, Neisseria meningitidis,

A9LZA2, Q9JUC4

Neisseria meningitidis

2063
VILGQDPYHGP

Bacillus methylotrophicus

A7ZA24
P13051

2064
VILTTGTFL

Campylobacter jejuni, Campylobacter

A8FMP4, Q5HTS6,
Q9Y2Z2

jejuni, Campylobacter jejuni,

A1W0H2, Q9PNA7,

Campylobacter jejuni, Campylobacter

A7H2I7

jejuni

2065
VILVGENPAS

Streptococcus suis, Streptococcus

A4VTM4, A4VZV9
P13995

suis

2066
VIWGNPANTN

Corynebacterium jeikeium

Q4JWV0
P40925

2067
VKAQKVRRLI

Acinetobacter baylyi, Acinetobacter

Q6FDY3, B0VS13,
Q9H0R6

baumannii, Acinetobacter baumannii,

A3M8F1, B0VEN3,

Acinetobacter baumannii,

B7GXC5, B2HY00,

Acinetobacter baumannii,

B7I7N2

Acinetobacter baumannii,

Acinetobacter baumannii

2068
VKELVENSLDA

Lactobacillus reuteri, Lactobacillus

B2G6E6, A5VIX0
Q13670

reuteri

2069
VKELVENSLDAGA

Akkermansia muciniphila, Clostridium

B2ULE2, Q0STR3,
Q13670

perfringens, Clostridium perfringens,

Q0TRD5, Q8XL86

Clostridium perfringens

2070
VKLSDYKGKY

Bacillus subtilis

Q796Y8
P32119

2071
VKMVHNGIEY

Staphylococcus aureus,

Q931R3, P63335,
P52209

Staphylococcus aureus,

Q6GGI7, Q6G954,

Staphylococcus aureus,

P63334, Q5HFR2,

Staphylococcus aureus,

Q8CP47, Q5HP42

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

2072
VKMVHNGIEYGD

Bacillus subtilis

P80859
P52209

MQLI

2073
VKRTGAIVDVPVG

Methylobacterium sp.,
B0UE41, B1LVH1,
P25705

Methylobacterium radiotolerans,

B1ZEE9, B8IN03,

Methylobacterium populi,

C3M9S3, Q92LK6,

Methylobacterium nodulans,

Q1MAZ0, B5ZSN9,

Rhizobium sp., Rhizobium meliloti,
Q2K3G8, Q98EV6,

Rhizobium leguminosarum,

B3PQ70

Rhizobium leguminosarum,

Rhizobium etli, Rhizobium loti,

Rhizobium etli

2074
VKSTLGPKG

Lactobacillus plantarum

Q88YM5
P78371

2075
VKVVILGQDPY

Bacteroides fragilis, Bacteroides

Q64QI5, Q5LA67
P13051

fragilis

2076
VKVVILGQDPYH

Lactobacillus brevis, Campylobacter

Q035K6, A7I0A8,
P13051

hominis, Campylobacter fetus,

A0RM89, B2RHL6,

Porphyromonas gingivalis,

Q7MXF6

Porphyromonas gingivalis

2077
VKVBVILGQDPYHG

Neisseria gonorrhoeae, Neisseria

B4RLL6, Q5F8I7,
P13051

gonorrhoeae, Pediococcus ntosaceus

Q03GV8

2078
VKVVILGQDPYHG

Bacillus licheniformis, Bacillus

Q65DN9, A8FIM7,
P13051

P

pumilus, Lactobacillus sakei,

Q38VY5, B2GAM7,

Lactobacillus fermentum, Citrobacter

A8AD07, A6M317,

koseri, Clostridium beijerinckii,

A4WDE9, Q92EQ0,

Enterobacter sp., Listeria innocua,
Q8Y9X7, Q723S4,

Listeria monocytogenes, Listeria

Q3KGL4, Q1BT6,

monocytogenes, Pseudomonas

Q4KGS0, A5W8H2,

fluorescens, Pseudomonas

C3KDS6, Q88N05,

entomophila, Pseudomonas

B0KV50, B1J4J3,

fluorescens, Pseudomonas putida,

B1IBW9, A4W30,

Pseudomonas fluorescens,

A4W1D5, C1CRP5,

Pseudomonas putida, Pseudomonas

C1QED4, P23379,

putida, Pseudomonas putida,

B8Z048, Q8DPQ4,

Streptococcus pneumoniae,

B5E4R3, Q04KE2,

Streptococcus suis, Streptococcus

C1CKR8

suis, Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

2079
VKVVILGQDPYHG

Acinetobacter baumannii,

B0VMZ7, A3M500,
P13051

PNQA

Acinetobacter baumannii,

B2HZE0, B0VD25,

Acinetobacter baumannii,

B7I526, B7H3L4,

Acinetobacter baumannii,

Q6F9Y2, A7GVX1

Acinetobacter baumannii,

Acinetobacter baumannii,

Acinetobacter baylyi, Campylobacter

curvus

2080
VKVVILGQDPYHG

Lactobacillus reuteri, Lactobacillus

A5VIJ2, B2G626
P13051

PNQAHG

reuteri

2081
VKVVILGQDPYHG

Bacillus clausii, Enterococcus

Q5WAZ9, Q836Z5,
P13051

PNQAHGL

faecalis, Haemophilus ducreyi,

Q7VMC0, Q49VD1

Staphylococcus saprophyticus

2082
VKVVILGQDPYHG

Aeromonas hydrophila, Aeromonas

A0KMZ1, A4SK71
P13051

PNQAHGLCFSV

salmonicida

2083
VKVVILGQDPYHG

Pseudomonas syringae,

Q4ZPC2, Q48ET5,
P13051

PNQAHGLCFSVQ

Pseudomonas savastanoi,

Q87XE2

Pseudomonas syringae

2084
VKYSPDCIIIV

Bacillus licheniformis

Q65G89
P07195

2085
VLASASPRR

Desulfitobacterium hafniense,

Q24SM2, Q97JN3,
O95671

Clostridium acetobutylicum,

Q74A46, Q39X87,

Geobacter sulfurreducens, Geobacter

B5EHR3, C6E559

metallireducens, Geobacter

bemidjiensis, Geobacter sp.

2086
VLATNIAET

Escherichia coli

P37024
Q7Z478

2087
VLAYEPVWAIGTG

Bacteroides fragilis, Bacteroides

Q64P83, Q5L923
P60174

KTA

fragilis

2088
VLAYSGGLDT

Corynebacterium glutamicum,

O85176, A4QDZ4
P00966

Corynebacterium glutamicum

2089
VLAYSGGLDTS

Aeromonas salmonicida, Aeromonas

A4SIM5, A0KFV3,
P00966

hydrophila, Lactobacillus reuteri,

B2G6Y6, A5VJH1,

Lactobacillus reuteri, Lactobacillus

Q033U7, A1A1W7,

casei, Bifidobacterium adolescentis,

Q8G5F2, B3DSY7,

Bifidobacterium longum,

B7GTP0, C5BC58,

Bifidobacterium longum,

P61523, Q39Z72,

Bifidobacterium longum, Edwardsiella

B9M374, C6E6Y6,

ictaluri, Geobacter sulfurreducens,

A5GDA4, B5ED13,

Geobacter metallireducens,

Q03W70, B1MZP4,

Geobacter daltonii, Geobacter sp.,
C1KX43, B8DH28,

Geobacter uraniireducens, Geobacter

Q71XS4, A0AKJ7,

bemidjiensis, Leuconostoc

Q929S9, Q8Y5H2,

mesenteroides, Leuconostoc citreum,

B9DIU4, Q49WA0,

Listeria monocytogenes, Listeria

Q8CPU3, Q5HQK0,

monocytogenes, Listeria

Q4L4X7, Q6GIC7,

monocytogenes, Listeria welshimeri,

A8Z067, P63644,

Listeria innocua, Listeria

P63645, A6QFH2,

monocytogenes, Staphylococcus

A5IRD9, Q5HHC4,

carnosus, Staphylococcus

Q2FZU1, Q2FIB4,

saprophyticus, Staphylococcus

A7X0H5, A6U068,

epidermidis, Staphylococcus

Q2YWS4, Q8NXF2,

epidermidis, Staphylococcus

Q6GAW5, B9DW9

haemolyticus, Staphylococcus

aureus, Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Streptococcus uberis

2090
VLDGGMGTMIQ

Escherichia coli

P13009
Q99707

2091
VLDVGCGSG

Haemophilus somnus

Q0I1M1
Q86X55

2092
VLDVGCGSGILS

Eubacterium rectale, Eubacterium

C4ZAZ2, C4Z0Q0
Q86X55

eligens

2093
VLEARDRVGGRT

Kocuria rosea

P40974
P21397

2094
VLFIADEIQ

Staphylococcus saprophyticus

Q49W96
P04181

2095
VLFIADEIQTGL

Bacillus subtilis

P38021
P04181

2096
VLGAQWGDEGKG

Clostridium botulinum, Clostridium

B2V1S6, B2TRE4,
Q8N142

K

botulinum, Clostridium botulinum,

C1FNL8, A7GJL2,

Clostridium botulinum, Clostridium

B1IHP2, A5I7Y9,

botulinum, Clostridium botulinum,

A7FZF9, C3KWG8,

Clostridium botulinum, Clostridium

B1KU85, Q97D87,

botulinum, Clostridium botulinum,

A6M3K0

Clostridium acetobutylicum,

Clostridium beijerinckii

2097
VLGEHGDSS

Lactobacillus plantarum

P59390
P00338

2098
VLGFPCNQF

Escherichia coli

P06610
P18283

2099
VLGIETSCD

Aeromonas hydrophila, Aeromonas

A0KGI3, A4SRB1,
Q9H4B0

salmonicida, Bacillus subtilis, Bacillus

O05518, Q65N07,

licheniformis, Citrobacter koseri,

A8APV4, A4WEJ9,

Enterobacter sp., Escherichia coli,

Q1R6R7, A1AFY6,

Escherichia coli, Escherichia coli,

Q0TD42, Q8FDG6,

Escherichia coli, Escherichia coli,

B7N068, B7MB00,

Escherichia coli, Escherichia coli,

Q8XBK3, B7UIX2,

Escherichia coli, Escherichia

B7LQD8, B6I436,

fergusonii, Escherichia coli,

B1IRQ2, A8A4M1,

Escherichia coli, Escherichia coli,

B7LZL4, B7NJS7,

Escherichia coli, Escherichia coli,

B7LGZ9, B5YRA4,

Escherichia coli, Escherichia coli,

A7ZRU6, P05852,

Escherichia coli, Escherichia coli,

B1LF56, B7ND53,

Escherichia coli, Escherichia coli,

C4ZQY1, B1XG69,

Escherichia coli, Escherichia coli,

A6TE46, B5XU22,

Klebsiella pneumoniae, Klebsiella

B4EW57, Q98Ei6

pneumoniae, Proteus mirabilis,

Rhizobium loti

2100
VLIIGSGGREH

Pseudomonas aeruginosa,

Q9HUV8, Q87VR8,
P22102

Pseudomonas syringae,

Q88DK2

Pseudomonas putida

2101
VLILDEATS

Streptococcus pneumoniae,

P59653, Q03727
Q9NUT2

Streptococcus pneumoniae

2102
VLITGCSSGIGL

Escherichia coli, Escherichia coli

P0AFP5, P0AFP4
P14061

2103
VLIVEDIID

Escherichia coli, Escherichia coli

P0A9M3, P0A9M2
P00492

2104
VLIVEDIIDTG

Haemophilus influenzae

P45078
P00492

2105
VLLGPPGAGKGT

Clostridium perfringens, Clostridium

Q8XHU4, Q0SQG5,
P54819

QA

perfringens, Clostridium perfringens,

Q0TMR7, A6LPT2,

Clostridium beijerinckii, Clostridium

B2TIJ6, B2UYD1,

botulinum, Clostridium botulinum,

B1VEX6

Corynebacterium urealyticum

2106
VLNGNEIGGGSIRI

Stenotrophomonas maltophilia,

B2FRP1, B45T40
Q6PI48

H

Stenotrophomonas maltophilia

2107
VLPIIVFFS

Haemophilus influenzae

P44742
O00377

2108
VLRSSIREFL

Pseudomonas putida, Pseudomonas

B0KN22, B1J2K5,
Q9BVL4

putida, Pseudomonas putida,

A5WAA1, Q88CVV2,

Pseudomonas putida, Pseudomonas

A4XPR2, Q11G73,

mendocina, Pseudomonas

Q87VB1, Q4KJF3,

entomophila, Pseudomonas syringae,

Q9HUE6, B7V3B6,

Pseudomonas fluorescens,

A4VRA3, A6VDE4,

Pseudomonas aeruginosa,

Q4ZZ58, C3KBV5,

Pseudomonas aeruginosa,

Q48P81, Q02EZ4,

Pseudomonas stutzeri, Pseudomonas

Q3KJ68

aeruginosa, Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas savastanoi,

Pseudomonas aeruginosa,

Pseudomonas fluorescens

2109
VLRSSIREFLCSEA

Ralstonia solanacearum

Q8XYL0
Q9BVL4

M

2110
VLSGGEKQRI

Plesiomonas shigelloides

Q93SS1
P33897

2111
VLSGPSGAGK

Desulfitobacterium hafniense

Q24TX4
Q16774

2112
VLTSVDRDD

Pseudomonas mendocina

A4XYX3
O43766

2113
VLTVRAHQANSH

Eubacterium rectale, Clostridium

C4Z8Z2, A9KP29
P13051

phytofermentans

2114
VLVEVNCETDFV

Geobacter uraniireducens, Geobacter

A5G7W7, B9M5C5,
P43897

daltonii, Geobacter sulfurreducens,

P61333, Q39W87,

Geobacter metallireducens,

C6E513, B5EHW0

Geobacter sp., Geobacter

bemidjiensis

2115
VLVKIAPDL

Corynebacterium diphtheriae

Q6NH79
Q02127

2116
VMEGFLRLR

Pseudomonas aeruginosa

Q9RPF2
P49279

2117
VMENGKVIE

Staphylococcus saprophyticus,

Q49W48, Q5HQQ9,
Q96J65

Staphylococcus epidermidis,

Q8CTB2

Staphylococcus epidermidis

2118
VMITGDNPLTA

Streptomyces coelicolor

Q9X8Z9
Q9HD20

2119
VMQEEIFGP

Staphylococcus haemolyticus

Q4L966
P51648

2120
VNAANSSLLGGG

Streptomyces nogalater

Q9EYI6
Q9BQ69

GVDG

2121
VNCNPETVSTD

Bifidobacterium longum,

Q8G815, B3Dq32,
P31327

Bifidobacterium longum,

B7GPW2, A1A0T4,

Bifidobacterium longum,

B8DTW3, P58939,

Bifidobacterium adolescentis,

Q8FT42, B2GI87,

Bifidobacterium animalis,

C5CCF1, Q9KXR6,

Corynebacterium glutamicum,

B1W463, Q827Q7

Corynebacterium efficiens, Kocuria

rhizophila, Micrococcus luteus,

Streptomyces coelicolor,

Streptomyces griseus, Streptomyces

avermitilis

2122
VNDAFGTAHR

Lactobacillus reuteri, Lactobacillus

B2G616, Q03SL7,
P07205

brevis, Lactobacillus acidophilus,

Q5FL50, A8YUE3,

Lactobacillus helveticus, Lactobacillus

P62413, B3WCVV5,

johnsonii, Lactobacillus casei,

Q03AK6, Q1WTB5,

Lactobacillus casei, Lactobacillus

Q042F2, Q8GIZ5,

salivarius, Lactobacillus gasseri,

Q1GB26, O32756,

Lactobacillus delbrueckii,

Q04BH1, Q2YSF1,

Lactobacillus delbrueckii,

A8Z1A1, Q2G031,

Lactobacillus delbrueckii,

P68820, Q2FIM0,

Lactobacillus delbrueckii,

P68821, A6QF82,

Staphylococcus aureus,

Q6GB57, A7WZS6,

Staphylococcus aureus,

P68819, A6TZQ2,

Staphylococcus aureus,

Q6GIL7, P99135,

Staphylococcus aureus,

Q5HHP4, A5IQX7,

Staphylococcus aureus,

B9DJJ6, Q5HQV3,

Staphylococcus aureus,

Q8CTD6, Q4L4K4,

Staphylococcus aureus,

Q49W00, A4VSN8,

Staphylococcus aureus,

A4VYY1, B4U0W3

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus carnosus,

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus,

Staphylococcus saprophyticus,

Streptococcus suis, Streptococcus

suis, Streptococcus equi

2123
VNDAFGTAHRA

Neisseria meningitidis, Neisseria

A1KWN6, A9LZI3,
P07205

meningitidis, Neisseria meningitidis,

Q9JW58, Q9K1R0,

Neisseria meningitidis, Neisseria

B4RPR1, Q5F5K5

gonorrhoeae, Neisseria gonorrhoeae

2124
VNDAFGTAHRAH

Akkermansia muciniphila,

B2UKW8, Q38Y20,
P07205

Lactobacillus sakei, Clostridium novyi,

A0PYP1, Q898R3,

Clostridium tetani, Clostridium

B9E6B4, A5N2N8,

kluyveri, Clostridium kluyveri,

Q8XKU0, Q0TQY7,

Clostridium perfringens, Clostridium

Q0STD5, B2UY23,

perfringens, Clostridium perfringens,

C1FQW3, A5HYC0,

Clostridium botulinum, Clostridium

A7FQN7, A7G9Y0,

botulinum, Clostridium botulinum,

C3KYR4, B1IDB6,

Clostridium botulinum, Clostridium

B2TPX4, B1KTJ5,

botulinum, Clostridium botulinum,

Q181T8, A6LR05,

Clostridium botulinum, Clostridium

Q833I9, Q03GW7,

botulinum, Clostridium botulinum,

B5XIF1, A3CKQ4,

ptoclostridium difficile, Clostridium

Q8NZG3, Q1J9Y4,

beijerinckii, Enterococcus faecalis,

Q1JK32, Q5XA18,

Pediococcus ntosaceus,

P68897, Q8DXT0,

Streptococcus pyogenes,

Q3JZB8, Q8E3F0,

Streptococcus sanguinis,

A2RCM1, Q8VVB6,

Streptococcus pyogenes,

Q03IS8, P0DD05,

Streptococcus pyogenes,

Q48RF9, P0DD04,

Streptococcus pyogenes,

Q1J4X9, Q8DW2,

Streptococcus pyogenes,

Q5LY23, A8AUR9,

Streptococcus pyogenes,

B9DVS0, C1C5M3,

Streptococcus agalactiae,

Q8D0X8, B2IMA2,

Streptococcus agalactiae,

C1CCP3, C1CIZ1,

Streptococcus agalactiae,

C1CQ04, Q04LZ5,

Streptococcus pyogenes,

B8ZLX5, B1IA36,

Streptococcus thermophilus,

Q97S89, C0M940,

Streptococcus thermophilus,

C0MF22, B5E1U9

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus mutans, Streptococcus

thermophilus, Streptococcus gordonii,

Streptococcus uberis, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus equi,

Streptococcus equi, Streptococcus

pneumoniae

2125
VNGAGLAMAT

Acinetobacter baylyi, Acinetobacter

Q6F8L4, B0VEF2,
Q96199

baumannii, Acinetobacter baumannii,

A3M887, B7I6T2,

Acinetobacter baumannii,

B2HXG0, B7GXK7,

Acinetobacter baumannii,

B0VSL0, B2UMH5,

Acinetobacter baumannii,

A7GRG6, B7HDV9,

Acinetobacter baumannii,

B7IUJ5, Q9KA20,

Akkermansia muciniphila, Bacillus

Q6HEX9, B9IVC5,

cytotoxicus, Bacillus cereus, Bacillus

Q636J0, B7HLG9,

cereus, Bacillus halodurans, Bacillus

C1EP60, Q732N4,

thuringiensis, Bacillus cereus, Bacillus

A0RHK9, Q819X0,

cereus, Bacillus cereus, Bacillus

Q81WK0, C3L791,

cereus, Bacillus cereus, Bacillus

C3P5N7, Q5WFP4,

thuringiensis, Bacillus cereus, Bacillus

A9VT74, Q8A9M7,

anthracis, Bacillus anthracis, Bacillus

A8FKV6, Q5HVN3,

anthracis, Bacillus clausii, Bacillus

Q9PHY1, A1VYP2,

weihenstephanensis, Bacteroides

A7H4K9, A7GYI5,

thetaiotaomicron, Campylobacter

B3E7B3, B4RL77,

jejuni, Campylobacter jejuni,

Q9JUT0, Q9JZP4,

Campylobacter jejuni, Campylobacter

Q5F878, A1KTM6,

jejuni, Campylobacter jejuni,

A9M4F8, B2UGE2,

Campylobacter curvus, Geobacter

Q8Y1Y3, Q9EYG9,

lovleyi, Neisseria gonorrhoeae,

Q1MAW1, Q98EC5,

Neisseria meningitidis, Neisseria

B5ZSR9, Q2K3F0,

meningitidis, Neisseria gonorrhoeae,

B3PQ90, A5VB78,

Neisseria meningitidis, Neisseria

Q49X32, Q8CPH5,

meningitidis, Ralstonia pickettii,

Q5HPU5, B2FRS3,

Ralstonia solanacearum, Rhizobium

B4ST72

meliloti, Rhizobium leguminosarum,

Rhizobium loti, Rhizobium

leguminosarum, Rhizobium etli,

Rhizobium etli, Sphingomonas

wittichii, Staphylococcus

saprophyticus, Staphylococcus

epidermidis, Staphylococcus

epidermidis, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

2126
VNGVAKIHSDI

Bacillus subtilis

P39123
P06737

2127
VNKSQSSND

Escherichia coli, Escherichia coli,

Q8X769, P05042,
P07954

Escherichia coli

Q8FHA7

2128
VNKSQSSNDT

Haemophilus ducreyi

Q7VKC9
P07954

2129
VNKSQSSNDTFPT

Staphylococcus epidermidis,

Q8CNR1, Q5HN85
P07954

AMH

Staphylococcus epidermidis

2130
VNKSQSSNDTFPT

Haemophilus influenzae

P71384
P07954

AMHIAA

2131
VNLTNHSYFNL

Acinetobacter calcoaceticus

P05149
Q96C23

2132
VNQGHCHPKI

Staphylococcus saprophyticus

Q4A0N2
P04181

2133
VNRIAAGEV

Sphingomonas wittichii

A5V3J3
P40692

2134
VNTTDSAVR

Eubacterium eligens, ptoclostridium

C4Z154, Q180Y2,
Q9UGC7

difficile, Clostridium phytofermentans,

A9KHD4, C4XIQ1

Desulfovibrio maeticus

2135
VNTTDSAVRI

Campylobacter curvus,

A7GW12, A7ZB10,
Q9UGC7

Campylobacter concisus,

Q5HSH9, A1W1L4,

Campylobacter jejuni, Campylobacter

A8FNS3, Q9PM63,

jejuni, Campylobacter jejuni,

A7H5W3, A713Q0,

Campylobacter jejuni, Campylobacter

B9KE98, Q0SQY1,

jejuni, Campylobacter hominis,

Q0TNB0, Q8XIB9,

Campylobacter lari, Clostridium

A5N3J7, Q97F68,

perfringens, Clostridium perfringens,

Q7VFA0, B6JP10,

Clostridium perfringens, Clostridium

B5Z680, Q17VT1,

kluyveri, Clostridium acetobutylicum,

P55998, Q1CV77,

Helicobacter hepaticus, Helicobacter

Q9ZMZ0

pylori, Helicobacter pylori,

Helicobacter acinonychis,

Helicobacter pylori, Helicobacter

pylori, Helicobacter pylori

2136
VNVQGTRNV

Escherichia coli

Q8X7P7
Q9H2F3

2137
VPAGVEDGQ

Lactobacillus sakei, Lactobacillus

O87778, Q38W94,
Q96EY1

sakei, Pediococcus ntosaceus

Q03FR6

2138
VPEEYGGLG

Bacillus subtilis

O32176
Q9H845

2139
VPESPRWLI

Bacillus subtilis

P94493
O75751

2140
VPETKGKTLE

Escherichia coli, Escherichia coli

P0AGF4, P0AGF5
Q9NY64

2141
VPETKGRSLEQ

Bacillus subtilis

P54723
Q9UGQ3

2142
VPGGFGIRG

Lactobacillus delbrueckii

Q04C51
Q9NRF8

2143
VPIGRGQRELIIGD

Clostridium phytofermentans

A9KK94
P25705

2144
VPIGRGQRELIIGD

Fusobacterium nucleatum,

Q8RGE0, A3DIM7,
P25705

RQTGKT

Clostridium thermocellum, Geobacter

B3EA03, B9LZ86,

lovleyi, Geobacter daltonii, Geobacter

Q74GY2, A5G9D6,

sulfurreducens, Geobacter

C6E9F3, B5EFI9

uraniireducens, Geobacter sp.,

Geobacter bemidjiensis

2145
VPLIGFAGAP

Bacillus pumilus, Listeria innocua,

A8FBM5, Q929G1,
P06132

Listeria monocytogenes, Listeria

Q8Y564, A0AKW5,

welshimeri, Listeria monocytogenes,

Q71XF3, B8DF98,

Listeria monocytogenes, Listeria

C1KXG7

monocytogenes

2146
VPVGEELLGRVV

Bacillus halodurans, Bacillus

Q9K6H3, P22477
P25705

pseudofirmus

2147
VQSLGGTGALRI

Haemophilus influenzae

P44425
P17174

2148
VRENTEGEYSSL

Escherichia coli, Pseudomonas putida

P76251, Q51945
P51553

2149
VRFAPSPTG

Desulfitobacterium hafniense

Q250Q8
Q5JPH6

2150
VRFSTVAGE

Bacteroides fragilis, Desulfovibrio

P45737, Q9ZN99
P04040

vulgaris

2151
VRGGGRKPW

Lactobacillus sakei, Enterococcus

Q38UR3, Q839G3,
Q9BYD3

faecalis, Pediococcus ntosaceus,

Q03EB7, B9DM18,

Staphylococcus carnosus,

Q49ZG7, Q8CRG1,

Staphylococcus saprophyticus,

Q5HM00, Q4L8B3

Staphylococcus epidermidis,

Staphylococcus epidermidis,

Staphylococcus haemolyticus

2152
VRGKDVFIIQ

Pseudomonas syringae,

Q888C6, Q88PX6
O60256

Pseudomonas putida

2153
VRGVAMNPV

Geobacter lovleyi, Geobacter

B3E7T8, Q39Y03,
P62917

metallireducens, Geobacter

A5GAW8, Q8XV15

uraniireducens, Ralstonia

solanacearum

2154
VRVRFAPSPTG

Bacillus halodurans, Parabacteroides

Q9KGF6, A6LEA1,
Q5JPH6

distasonis, Bacteroides

Q8A455, Q64NI3,

thetaiotaomicron, Bacteroides fragilis,

Q5L883, A6L0E8

Bacteroides fragilis, Bacteroides

vulgatus

2155
VRVRFAPSPTGF

ptoclostridium difficile

Q18CD6
Q5JPH6

2156
VRVRFAPSPTGFL

Finegoldia magna

B0S0W2
Q5JPH6

H

2157
VSEAGASIYS

Neisseria meningitidis, Neisseria

P57072, Q51152,
Q8N5C6

meningitidis, Neisseria gonorrhoeae

Q51062

2158
VSEDMLGRVF

Clostridium botulinum, Clostridium

B2TP90, B2UWY3,
P15313

botulinum, Clostridium tetani,

Q896K3, Q0TPW8,

Clostridium perfringens, Clostridium

Q0SSI3, Q8XJW6,

perfringens, Clostridium perfringens,

A7GGL3, B1IJM7,

Clostridium botulinum, Clostridium

B1KXT5, C1FTN6,

botulinum, Clostridium botulinum,

A51556, A7FWQ6,

Clostridium botulinum, Clostridium

C3L1B0

botulinum, Clostridium botulinum,

Clostridium botulinum

2159
VSGGTDNHL

Aeromonas salmonicida, Aeromonas

A4SJN4, A0KNH4
P34897

hydrophila

2160
VSHGATGKGNDQ

Sphingomonas wittichii

A5VAK5
P00966

VRFEL

2161
VSNHGGRQLD

Acinetobacter baylyi, Acinetobacter

Q6FFS1, B0VND0,
Q9NYQ3

baumannii, Acinetobacter baumannii,

B7IBS4, B0V6L1,

Acinetobacter baumannii,

A3M0X0, B2I061,

Acinetobacter baumannii,

B7H2H0, A8ARJ1,

Acinetobacter baumannii,

A4W540, B7NER0,

Acinetobacter baumannii, Citrobacter

P33232, B1IZ15,

koseri, Enterobacter sp., Escherichia
A8A670, B1X8M0,

coli, Escherichia coli, Escherichia coli,

C4ZXJ7, B1LK44,

Escherichia coli, Escherichia coli,

B6BI4, B7M492,

Escherichia coli, Escherichia coli,

B5YWA7, Q8XDF7,

Escherichia coli, Escherichia coli,

B7L725, A7ZTF9,

Escherichia coli, Escherichia coli,

B7N251, B7ULG1,

Escherichia coli, Escherichia coli,

Q1R4Z0, B7MFG9,

Escherichia coli, Escherichia coli,

Q8FCB1, Q0TBK1,

Escherichia coli, Escherichia coli,

B7NPB4, A1AHE2,

Escherichia coli, Escherichia coli,

B7LTL2, P46454,

Escherichia coli, Escherichia coli,

A5UFG9, A5UBE3,

Escherichia fergusonii, Haemophilus

Q4QJK8, Q7VPI9,

influenzae, Haemophilus influenzae,

A6TFK0, B5XMV0,

Haemophilus influenzae,

Q1IF69, B1J244,

Haemophilus influenzae,

A6VCM8, A5W9B2,

Haemophilus ducreyi, Klebsiella

Q88DT3, Q02FQ1,

pneumoniae, Klebsiella pneumoniae,

B0KIT4, Q9HV37,

Pseudomonas entomophila,

B7V113, Q4ZY06,

Pseudomonas putida, Pseudomonas

C3K053, B4SMK1,

aeruginosa, Pseudomonas putida,

B2FIJ0

Pseudomonas putida, Pseudomonas

aeruginosa, Pseudomonas putida,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas syringae,

Pseudomonas fluorescens,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

2162
VSNPVDILTY

Clostridium acetobutylicum,

Q97MD1, Q0SWR1,
Q9BYZ2

Clostridium perfringens, Clostridium

Q0TUX8, Q8XP62

perfringens, Clostridium perfringens

2163
VSNPVDILTYV

Clostridium tetani

Q892U0
Q9BYZ2

2164
VSSDRGLCG

Geobacter uraniireducens,

A5G9D7, Q88BX3,
P36542

Pseudomonas putida, Pseudomonas

A5WBA4, B0KRA9,

putida, Pseudomonas putida,

Q1I2I6, Q3K440,

Pseudomonas entomophila,

Q4ZL23, Q48BG4,

Pseudomonas fluorescens,

Q87TT3, B1JFU2,

Pseudomonas syringae,

C3K1E7, Q4K3A8,

Pseudomonas savastanoi,

B7V792, Q9HT19,

Pseudomonas syringae,

Q02DF3, A6VF33

Pseudomonas putida, Pseudomonas

fluorescens, Pseudomonas

fluorescens, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa

2165
VTAGLAIYDTMQYI

Eubacterium rectale

C4ZGF4
Q16740

2166
VTFHRAFDM

Citrobacter koseri, Edwardsiella

A8AFG8, C5B835,
Q9NTM9

ictaluri, Enterobacter sp., Escherichia
A4WBM9, B1LCZ7,

coli, Escherichia coli, Escherichia coli,

B7NS44, B5YR19,

Escherichia coli, Escherichia coli,

Q8XCH4, A8A176,

Escherichia coli, Escherichia coli,

B1J0L4, Q8FGQ2,

Escherichia coli, Escherichia coli,

Q0TGV9, B7USQ1,

Escherichia coli, Escherichia coli,

B7MW68, B7L7S7,

Escherichia coli, Escherichia coli,

B7NBM5, B6IIF2,

Escherichia coli, Escherichia coli,

P67826, B1XHE2,

Escherichia coli, Escherichia coli,

B7M2G5, C4ZQF8,

Escherichia coli, Escherichia coli,

A7ZNQ0, Q1RAR0,

Escherichia coli, Escherichia coli

B7MBT3, A1AC35

2167
VTGAAGQIAYSLL

Akkermansia muciniphila,

B2UKY5, P61974,
P40925

Corynebacterium diphtheriae,

Q8FN62

Corynebacterium efficiens

2168
VTGAAQGIGR

Acinetobacter baylyi

P07772
P15428

2169
VTGAGKGIG

Escherichia coli

P15047
Q7Z4W1

2170
VTGAGSGIG

Staphylococcus aureus,

Q8NUV9, Q6G6J1,
Q92506

Staphylococcus aureus,

Q99RF5, Q7A3L9,

Staphylococcus aureus,

Q6GDV6, Q2FVD5,

Staphylococcus aureus,

Q5HD73, Q2FE21

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

2171
VTGASRGIG

Pseudomonas aeruginosa

O54438
Q96LJ7

2172
VTGASRGIGR

Bacillus subtilis, Escherichia coli

P51831, P0AEK2
Q96LJ7

2173
VTGASSGIG

Rhizobium sp., Staphylococcus
P55434, Q4A054
Q9Y394

saprophyticus

2174
VTGASSGIGE

Staphylococcus epidermidis,

Q5HLD8, Q8CN40
Q9Y394

Staphylococcus epidermidis

2175
VTGSTSGIG

Bacillus subtilis

Q32229
Q13268

2176
VTILGHVQRGGTP

Finegoldia magna

B0S230
Q01813

2177
VTIMGHVDHGKT

Rhizobium meliloti

Q92SW4
P46199

2178
VTLELGGKNP

Escherichia coli

P80668
P43353

2179
VTLELGGKSP

Bacillus subtilis, Bacillus subtilis,

P46329, O34660,
P51648

Pseudomonas oleovorans

P12693

2180
VTLYHWDLPQ

Bifidobacterium breve

P94248
Q9UEF7

2181
VTTTTHKTLRG

Lactobacillus sakei, Lactobacillus

Q38WJ7, A5VIP9,
P34897

reuteri, Lactobacillus reuteri,

B2G679, A6LUK9,

Clostridium beijerinckii, Clostridium

A7GGI2, B1IJJ8,

botulinum, Clostridium botulinum,

B1KXQ5, C3L181,

Clostridium botulinum, Clostridium

C1FTF1, Q183G0,

botulinum, Clostridium botulinum,

A5I526, A7FWM6,

ptoclostridium difficile, Clostridium

Q9HVI7, P66804,

botulinum, Clostridium botulinum,

Q6G7J7, Q6GEW2,

Pseudomonas aeruginosa,

P66803, P99091,

Staphylococcus aureus,

A6QIV7, Q5HE87,

Staphylococcus aureus,

Q2FWE5, A5IUQ8,

Staphylococcus aureus,

A7X4V7, A6U3J8,

Staphylococcus aureus,

Q49Z60, Q2YUJ1,

Staphylococcus aureus,

A8YY80, Q2FF15,

Staphylococcus aureus,

Q4L7Z4, Q8CRN3,

Staphylococcus aureus,

Q5HMB0

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

2182
VVAGETGSGK

Haemophilus influenzae

P45018
Q7Z478

2183
VVAHRLSTV

Streptomyces coelicolor

Q9ZNB0
Q9NP58

2184
VVAIGECGLDF

Citrobacter koseri, Citrobacter

A8ACY8, D2TUZ4,
Q6P1N9

rodentium, Enterobacter sp.,
A4WFX9, E3G381,

Enterobacter liolyticus, Escherichia

P27859, B7LTZ5,

coli, Escherichia fergusonii, Klebsiella

B5XYH5

pneumoniae

2185
VVDDLLATGGT

Aeromonas hydrophila, Aeromonas

A0KKD3, A4SMN3,
P07741

salmonicida, Fusobacterium

Q8RDM9, A8AJX4,

nucleatum, Citrobacter koseri,

A6LTN5, A4W7F3,

Clostridium beijerinckii, Enterobacter

Q8XD48, B5Z3X9,

sp., Escherichia coli, Escherichia coli,
B7LLQ1, Q1RF67,

Escherichia fergusonii, Escherichia

P69504, B1XFQ6,

coli, Escherichia coli, Escherichia coli,

Q0TKH2, B7M3W1,

Escherichia coli, Escherichia coli,

B1LJM6, B6I0C1,

Escherichia coli, Escherichia coli,

B7N922, C4ZUS3,

Escherichia coli, Escherichia coli,

B1IZC5, A1A8D5,

Escherichia coli, Escherichia coli,

B7NIG1, B7MDZ1,

Escherichia coli, Escherichia coli,

A7ZXC7, B7L794,

Escherichia coli, Escherichia coli,

P69503, B7UKE9,

Escherichia coli, Escherichia coli,

A7ZIM8, B7MQI4,

Escherichia coli, Escherichia coli,

Q7VKQ4, B5Y0N8,

Haemophilus ducreyi, Klebsiella

A6T5N2

pneumoniae, Klebsiella pneumoniae

2186
VVGNPANTN

Acinetobacter baylyi, Acinetobacter

Q6F7X1, B0V6R7,
P40925

baumannii, Acinetobacter baumannii,

A3M928, B2HZ52,

Acinetobacter baumannii,

B7I9D2, B7GW58,

Acinetobacter baumannii,

B0VQX5, Q8NN33,

Acinetobacter baumannii,

A4QGA0, Q8XXW5,

Acinetobacter baumannii,

B2U705, B2FQL8,

Corynebacterium glutamicum,

B4SLI5, Q9K3J3,

Corynebacterium glutamicum,

Q82HS2, B1W3N4

Ralstonia solanacearum, Ralstonia

pickettii, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia, Streptomyces coelicolor,

Streptomyces avermitilis,

Streptomyces griseus

2187
VVGPEAPLAAGIV

Ralstonia solanacearum

Q8XXC4
P22102

2188
VVGTSSLRR

Bacillus licheniformis, Desulfovibrio

Q65GK1, C6BYB7,
P08397

salexigens, Desulfovibrio alaskensis,

Q30Y29, Q9JVS4,

Neisseria meningitidis, Neisseria

Q9K0P6, Q8XWW3

2189
VVIGADTIV

meningitidis, Ralstonia solanacearum

Bacillus pumilus

A8FFU1
O95671

2190
VVILGQDPYHG

Haemophilus somnus, Pseudomonas

Q0I271, P29950,
P13051

denitrificans, Ralstonia pickettii,

B2UDL1, Q92LU5

Rhizobium meliloti

2191
VVILGQDPYHGPN

Streptococcus thermophilus

Q03KM6
P13051

QA

2192
VVILGQDPYHGPN

Proteus mirabilis

B4F058
P13051

QAHGL

2193
VVIVRDDLLG

Pseudomonas stutzeri

Q9R102
Q9Y617

2194
VVKHEVTGL

Bacillus subtilis

O34413
Q96MS3

2195
VVKRLPKTRSGK

Pseudomonas aeruginosa

P28812
Q9NUB1

2196
VVLAYSGGLDT

Eubacterium rectale,

C4Z9C9, B1VH30,
P00966

Corynebacterium urealyticum,

Q4JVZ8

Corynebacterium jeikeium

2197
VVLAYSGGLDTS

Arcobacter butzleri, Lactobacillus

A8EUB2, Q1WV65,
P00966

salivarius, Bacillus halodurans,

Q9K820, A8FG70,

Bacillus pumilus, Bacillus

Q65G67, Q5WED8,

licheniformis, Bacillus clausii, Bacillus

O34347, A7GTR5,

subtilis, Bacillus cytotoxicus, Bacillus

Q633G4, C1EUX9,

cereus, Bacillus cereus, Bacillus

A0RJM4, Q81KV7,

thuringiensis, Bacillus anthracis,

C3L9T6, C3PB97,

Bacillus anthracis, Bacillus anthracis,

A7Z7M0, Q6HCP7,

Bacillus methylotrophicus, Bacillus

B7JS06, B9J0E1,

thuringiensis, Bacillus cereus, Bacillus

P61520, A9VKE1,

cereus, Bacillus cereus, Bacillus

B7HRS7, Q817C6,

weihenstephanensis, Bacillus cereus,

B7H6Y5, B7IK29,

Bacillus cereus, Bacillus cereus,

B8FWX2, Q24ZG8,

Bacillus cereus, Desulfitobacterium

A0RP84, A7GYN4,

hafniense, Desulfitobacterium

A7I281, A7ZDF2,

hafniense, Campylobacter fetus,

Q9PHK7, B9KG97,

Campylobacter curvus,

A8FL83, A1VZ24,

Campylobacter hominis,

Q5HVA9, A7H4E9,

Campylobacter concisus,

A0Q1Z2, P59602,

Campylobacter jejuni, Campylobacter

A5N6U2, B9E0B1,

lari, Campylobacter jejuni,

Q186Z6, C1FU68,

Campylobacter jejuni, Campylobacter

A7GGQ9, A5I5A4,

jejuni, Campylobacter jejuni,

A7FWU6, C3L1U3,

Clostridium novyi, Clostridium tetani,

Q97KE6, B1KXY1,

Clostridium kluyveri, Clostridium

B1IK08, A6M1Z4,

kluyveri, ptoclostridium difficile,

P61521, Q8FTM9,

Clostridium botulinum, Clostridium

C4LIE1, Q30Y138,

botulinum, Clostridium botulinum,

B8DN64, P61522,

Clostridium botulinum, Clostridium

A1VEQ0, Q7VGU9,

botulinum, Clostridium

B2GKD7, Q4K749,

acetobutylicum, Clostridium

Q3K7K0, B7UW5,

botulinum, Clostridium botulinum,

Q9HY84, Q02QZ6,

Clostridium beijerinckii,

A6V1S1, Q48F14,

Corynebacterium diphtheriae,

Q87XM3, C3KBZ2,

Corynebacterium efficiens,

A4VIU7, Q4ZPK0,

Corynebacterium kropnstedtii,

A4XS43, B1J4I4,

Desulfovibrio alaskensis,

P59604, A5VZI0,

Desulfovibrio vulgaris, Desulfovibrio

Q11E03, B0KUE7,

vulgaris, Desulfovibrio vulgaris,

Q92L73, Q1MAN9,

Helicobacter hepaticus, Kocuria

Q2K3B7, Q98E81,

rhizophila, Pseudomonas fluorescens,

Q827Z1, B1W3B3,

Pseudomonas fluorescens,

P50986

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas aeruginosa,

Pseudomonas savastanoi,

Pseudomonas syringae,

Pseudomonas fluorescens,

Pseudomonas stutzeri, Pseudomonas

syringae, Pseudomonas mendocina,

Pseudomonas putida, Pseudomonas

putida, Pseudomonas putida,

Pseudomonas entomophila,

Pseudomonas putida, Rhizobium

meliloti, Rhizobium leguminosarum,

Rhizobium etli, Rhizobium loti,

Streptomyces avermitilis,

Streptomyces griseus, Streptomyces

clavuligerus

2198
VVLGAQWGDEGK

Clostridium novyi, Clostridium

A0PXA8, Q8XH63,
Q8N142

GK

perfringens, Haemophilus somnus,

Q0I4O5, B4SS80

Stenotrophomonas maltophilia

2199
VVLGHSERR

Clostridium botulinum, Clostridium

B2UY22, B2TPX3,
P60174

botulinum, Clostridium beijerinckii

A6LRO6

2200
VVLVGGSTR

Corynebacterium glutamicum,

A4QHJ0, Q8NLY6
P48723

Corynebacterium glutamicum

2201
VVPESPRWL

Bacillus subtilis

P96710
O75751

2202
VVTEAGFGAD

Leuconostoc mesenteroides

Q03YB1
P11586

2203
VVTIMGHVDHGKT

Bacillus cereus, Bacillus cereus,

B9IVA1, B7HLE6,
P46199

TLLD

Bacillus cereus, Bacillus anthracis,

Q73209, Q81WM3,

Bacillus anthracis, Bacillus anthracis,

C3P5L5, C3L7B4,

Bacillus thuringiensis, Bacillus cereus,

Q6HF02, Q636L3,

Bacillus thuringiensis, Bacillus cereus,

A0RHI4, C1EP35,

Bacillus cereus, Bacillus cereus,

Q812X7, B7HDT6,

Bacillus cereus, Bacillus cytotoxicus,

B7IUH1, A7GRE3,

Bacillus weihenstephanensis,

A9VT50, B9DPF5,

Staphylococcus carnosus,

Q8C5T4, Q5HPS2,

Staphylococcus epidermidis,

Q49X54, P65134,

Staphylococcus epidermidis,

P65133, Q2YXP7,

Staphylococcus saprophyticus,

A5ISF3, A7X1Q1,

Staphylococcus aureus,

A6U188, Q6GHG6,

Staphylococcus aureus,

A8Z3U9, A6QGG8,

Staphylococcus aureus,

Q5HGG2, Q2G2D0,

Staphylococcus aureus,

Q2FHG9, Q8NWZ1,

Staphylococcus aureus,

Q6G9U4, Q4L5X1

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus

2204
VVVGPEAPL

Streptomyces coelicolor

Q9RKL4
P22102

2205
VVYGITTGFGKF

Bacillus cereus, Bacillus cereus,

Q733H8, Q637H8,
P42357

Bacillus cereus, Bacillus anthracis,

B7J180, Q81Y45,

Bacillus anthracis, Bacillus anthracis,

C3L982, C3P4M2,

Bacillus cereus, Bacillus cytotoxicus,

Q81AC6, A7GRO0,

Bacillus weihenstephanensis, Bacillus

A9VPT8, B7HCD0,

cereus, Bacillus cereus, Bacillus

B9IUH0, B7HKJ1,

cereus, Bacillus thuringiensis, Bacillus

Q6HFE9, B7I5J2,

cereus, Bacillus thuringiensis, Bacillus

A0RH39, C1EN93

cereus

2206
VWCSNDYLGM

Rhizobium radiobacter, Rhizobium

P26505, P08080
P22557

mel iloti

2207
VWQTGSGTQ

Bacillus halodurans

Q9KCX4
P07954

2208
VWVDLEMTGLD

Corynebacterium glutamicum,

Q8NMU1, A4QGM5,
Q9Y3B8

Corynebacterium glutamicum,

Q8FMX9

Corynebacterium efficiens

2209
VWVSEVMLQQT

Bacillus subtilis

O31584
Q9UIF7

2210
VYDQMPEPRYV

Desulfovibrio desulfuricans

B8J1D6
O75251

2211
VYGITTGFG

Staphylococcus aureus,

A8YYT1, A60D47,
P42357

Staphylococcus aureus,

Q5HJY8, Q2G2P7,

Staphylococcus aureus,

Q2FKP8, Q2YUR3,

Staphylococcus aureus,

Q8NYY3, Q6GD82,

Staphylococcus aureus,

P64416, P64415,

Staphylococcus aureus,

A5INP9, A6TXF8,

Staphylococcus aureus,

Q6GKT7

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

2212
WAHLDIAGV

Desulfovibrio desulfuricans,

B8J457, B7KYK4,
P28838

Methylobacterium extorquens,

A9VXD6, B1ZAK8,

Methylobacterium extorquens,

B1LVC3

Methylobacterium populi,

Methylobacterium radiotolerans

2213
WAIGTGKTA

Acinetobacter baumannii,

B7H1F6, B2I2M3,
P60174

Acinetobacter baumannii,

B0VLU6, A3M1K0,

Acinetobacter baumannii,

B0VE65, B7I3R5,

Acinetobacter baumannii,

A8YUE4, Q5FL49,

Acinetobacter baumannii,

Q04BH0, Q1GB25,

Acinetobacter baumannii,

O32757, Q93GB7,

Lactobacillus helveticus, Lactobacillus

Q042F3, Q74K79,

acidophilus, Lactobacillus delbrueckii,

Q38Y19, B0S1G9,

Lactobacillus delbrueckii,

Q03GW6, P96985

Lactobacillus delbrueckii,

Lactobacillus delbrueckii,

Lactobacillus gasseri, Lactobacillus

johnsonii, Lactobacillus sakei,

Finegoldia magna, Pediococcus

ntosaceus, Rhizobium etli

2214
WAIGTGKTAT

Lactobacillus casei, Lactobacillus

B3WCVV6, Q03AK5,
P60174

casei, Lactobacillus salivarius,

Q1WSX9, Q88YH4,

Lactobacillus plantarum, Clostridium

Q898R2, A5N2N7,

tetani, Clostridium kluyveri,

A0PYP2, A3DBQ1,

Clostridium novyi, Clostridium

B1KTJ6, A7FQN8,

thermocellum, Clostridium botulinum,

A7G9Y1, B1IDB7,

Clostridium botulinum, Clostridium

O52633, Q8XKU1,

botulinum, Clostridium botulinum,

Q0TQY8, Q0STD6

Clostridium acetobutylicum,

Clostridium perfringens, Clostridium

perfringens, Clostridium perfringens

2215
WAKQGVLLLN

Campylobacter jejuni, Campylobacter

Q5HX80, Q9PJ40,
P13051

jejuni, Campylobacter jejuni,

A1VXG9, A8FJP1,

Campylobacter jejuni, Campylobacter

B9KEK7

lari

2216
WAKQGVLLLNAVL

Leuconostoc citreum

B1MXY4
P13051

TV

2217
WCISRQLWWGH

Campylobacter jejuni, Campylobacter

Q5HV17, Q9PPE4,
P26640

jejuni, Neisseria meningitidis,

Q9JX22, Q5F5W0,

Neisseria gonorrhoeae, Neisseria

Q9K1H7

meningitidis

2218
WCISRQLWWGHR

Helicobacter hepaticus

Q7VHN2
P26640

IP

2219
WCISRQLWWGHR

Bacillus cereus, Bacillus cereus,

Q817R6, Q633Y6,
P26640

IPA

Bacillus cereus, Bacillus anthracis,

Q72ZW8, Q81LD3,

Bacillus thuringiensis,

Q6HD68, B2FMS2,

Stenotrophomonas maltophilia,

B4SJ70

Stenotrophomonas maltophilia

2220
WCISRQLWWGHR

Porphyromonas gingivalis,

B2RK53, Q7MVD7
P26640

IPAY

Porphyromonas gingivalis

2221
WCISRQLWWGHR

Parabacteroides distasonis,

A6LIG7, Q64XH6,
P26640

IPAYF

Bacteroides fragilis, Bacteroides

Q5LGN1, Q89ZM4,

fragilis, Bacteroides thetaiotaomicron,

A6L3G7

Bacteroides vulgatus

2222
WDLRKTQPY

Propionibacterium acnes

Q6A6G1
O75306

2223
WDWVGGRYSLW

Acinetobacter baumannii,

A3M0W5, B2IQ56,
P06744

S

Acinetobacter baumannii,

B0VMS2, B7H2H4,

Acinetobacter baumannii,

B0V6J2

Acinetobacter baumannii,

Acinetobacter baumannii

2224
WDWVGGRYSLW

Pseudomonas mendocina,

A4XYC6, B0KHW6,
P06744

SAIGL

Pseudomonas putida, Pseudomonas

B1J2C0, Q88DW7,

putida, Pseudomonas putida,

A5W976, Q88LW9,

Pseudomonas putida, Pseudomonas

Q1I4P0, A4VPM9,

putida, Pseudomonas entomophila,

Q3K6Q4, Q4K5Y1,

Pseudomonas stutzeri, Pseudomonas

C3K249, Q9HV67,

fluorescens, Pseudomonas

B7V1E4, Q02FU0,

fluorescens, Pseudomonas

A6VCI8, Q84814,

fluorescens, Pseudomonas

Q48N88, Q4ZY88,

aeruginosa, Pseudomonas

Q88807

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

aeruginosa, Pseudomonas

fluorescens, Pseudomonas

savastanoi, Pseudomonas syringae,

Pseudomonas syringae

2225
WDYAHCLPYF

Staphylococcus xylosus,

Q9X2M2, Q4A0Q1
Q8NE62

Staphylococcus saprophyticus

2226
WIIDPIDGT

Bacillus subtilis, Corynebacterium

P29218

glutamicum

Q45499, Q8NS80

2227
WKKNGWKTS

Clostridium thermocellum

A3DD79
O60930

2228
WLEVLGCGV

Campylobacter lari

B9KD77
O95363

2229
WLFDCGEGTQ

Citrobacter koseri, Enterobacter sp.,
A8ADW5, A4WCQ3,
Q9H777

Enterococcus faecalis, Escherichia

Q834G2, B7MXV1,

coli, Escherichia coli, Escherichia coli,

B7NNU8, A1ADC0,

Escherichia coli, Escherichia coli,

Q1R9E5, Q8FFK8,

Escherichia coli, Escherichia coli,

B7MG36, Q0TFH3,

Escherichia coli, Escherichia coli,

B7N5N4, B617L2,

Escherichia coli, Escherichia coli,

A8A2D6, B1IXR8,

Escherichia coli, Escherichia coli,

P0A8V0, C4ZUB1,

Escherichia coli, Escherichia coli,

B7UFT1, B7M5V1,

Escherichia coli, Escherichia coli,

B7LAT4, A7ZP87,

Escherichia coli, Klebsiella

Q8XCZ0, B5XNW7,

pneumoniae, Klebsiella pneumoniae,

A6TBW1, A4WZ0,

Streptococcus suis, Streptococcus

A4W299, C1CQF2,

suis, Streptococcus pneumoniae,

C1CJE0, B2IMY3,

Streptococcus pneumoniae,

B1IAL2, C1C636,

Streptococcus pneumoniae,

C1CD41, Q8DQN1,

Streptococcus pneumoniae,

Q97RW2, B8ZMQ6,

Streptococcus pneumoniae,

Q04LL3, B5E2R6

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae

2230
WLHVDAAWGG

Haemophilus influenzae

P71362
Q9Y600

2231
WLTGLSGAGK

Pseudomonas aeruginosa

P57702
Q43252

2232
WNDMNEPSVFN

Bacillus thermoamyloliquefaciens

Q9F234
Q14697

2233
WPMTFGLACCA

Geobacter uraniireducens, Geobacter

A5G9B8, B5EFG2,

bemidjiensis, Geobacter daltonii,

B9LZL8, C6E8N4,
O75251

Geobacter sp., Geobacter
Q74GA7, Q39QA8,

sulfurreducens, Geobacter

B3E9W8

metallireducens, Geobacter lovleyi

2234
WPMTFGLACCAV

Stenotrophomonas maltophilia,

B2FNX8, B45QT5
O75251

EMMH

Stenotrophomonas maltophilia

2235
WQTGSGTQTNMN

Helicobacter pylori, Helicobacter

Q9ZJQ9, O25883
P07954

pylori

2236
WRLNERHYG

Lactobacillus sakei, Lactobacillus

Q38Z74, Q38ZH8,

sakei, Fusobacterium nucleatum,

Q8RFG9, B3DQI6,
P15259

Bifidobacterium longum,

B7GUR7, P59159,

Bifidobacterium longum,

Q4JSW4, Q6NJL2,

Bifidobacterium longum,

C4LLD4, Q8FSH0,

Corynebacterium jeikeium,

A40B41, Q8NTA5,

Corynebacterium diphtheriae,

A1VAI9, Q727C0,

Corynebacterium kropnstedtii,

Q839H4, Q74CR0,

Corynebacterium efficiens,

C6E639, B5EC38,

Corynebacterium glutamicum,

B8F5J4, P44865,

Corynebacterium glutamicum,

Q40ME2, A5UDW8,

Desulfovibrio vulgaris, Desulfovibrio

A5UHR1, Q0I4D8,

vulgaris, Enterococcus faecalis,

Q7VL28, Q929G8,

Geobacter sulfurreducens, Geobacter

A0AKV8, B8DFA5,

sp., Geobacter bemidjiensis,
Q8Y571, Q71XG0,

Haemophilus parasuis, Haemophilus

C1KXG0, Q6AAU8,

influenzae, Haemophilus influenzae,

Q4L8T0, A2RDV4,

Haemophilus influenzae,

P0DD06, Q1JAX0,

Haemophilus influenzae,

B5XM69, Q1JL20,

Haemophilus somnus, Haemophilus

Q1JG44, P65711,

ducreyi, Listeria innocua, Listeria

P0DD07, Q5X1388,

welshimeri, Listeria monocytogenes,

Q1J5W1, Q485P2,

Listeria monocytogenes, Listeria

Q99Z29, B1VS80,

monocytogenes, Listeria

P33158, Q82GB8

monocytogenes, Propionibacterium

acnes, Staphylococcus haemolyticus,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptococcus pyogenes,

Streptomyces griseus, Streptomyces

coelicolor, Streptomyces avermitilis

2237
WRLNERHYGGL

Desulfovibrio maeticus, Desulfovibrio

C4XIQ5, B8DLN4,
P15259

vulgaris, Staphylococcus

Q49ZZ2, B9DL85,

saprophyticus, Staphylococcus

Q8CN61, Q5HLI0,

carnosus, Staphylococcus

Q6GE17, A5IVJ6,

epidermidis, Staphylococcus

A8YYG4, Q5HDD9,

epidermidis, Staphylococcus aureus,

P65709, A6U4E6,

Staphylococcus aureus,

Q2FE81, A7X656,

Staphylococcus aureus,

Q6G605, A6QJQ5,

Staphylococcus aureus,

Q2FVK8, P65708,

Staphylococcus aureus,

P99153, Q2YVZ6,

Staphylococcus aureus,

B2FHH6, B4SPL6

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Stenotrophomonas maltophilia,

Stenotrophomonas maltophilia

2238
WRLNERHYGGLT

Streptococcus agalactiae,

Q3K1U2, Q8E643,
P15259

G

Streptococcus agalactiae,

Q8E0G9, P59161,

Streptococcus agalactiae,

B9DUS6, B4U1Y5,

Streptococcus mutans, Streptococcus

C0MCW5, C0M8R8

uberis, Streptococcus equi,

Streptococcus equi, Streptococcus

equi

2239
WRLNERHYGGLT

Streptococcus suis

A4W369
P15259

GLNKAE

2240
WRLNERHYGGLT

Sphingomonas wittichii

A5VB15
P15259

GLNKAETAA

2241
WSLLDNFEW

Clostridium thermocellum

P26208
Q9H227

2242
WSSCNIFSTQD

Pseudomonas aeruginosa,

Q9I685, B7V419,
P23526

Pseudomonas aeruginosa,

Q02TY0, A4VRF7,

Pseudomonas aeruginosa,

A4XPF3

Pseudomonas stutzeri, Pseudomonas

mendocina

2243
WTTTPWTLP

Acinetobacter baylyi, Aeromonas

Q6FG02, A0KG39,
P41252

hydrophila, Aeromonas salmonicida,

A4S1X5, A8E562,

Arcobacter butzleri, Bacillus cereus,

Q81E30, Q739A1,

Bacillus cereus, Bacillus thuringiensis,

A0RDG3, Q6HJF2,

Bacillus thuringiensis, Bacillus

Q81R75, Q63BZ8,

anthracis, Bacillus cereus, Bacillus

Q6HER9, C1EPQ9,

thuringiensis, Bacillus cereus, Bacillus

B7JJY2, Q636D1,

cereus, Bacillus cereus, Bacillus

B7H6N1, Q819R4,

cereus, Bacillus cereus, Bacillus

Q732H4, B9IVX2,

cereus, Bacillus cereus, Bacillus

B7HLM9, B7IUQ5,

cereus, Bacillus cereus, Bacillus

C3L730, C3P665,

anthracis, Bacillus anthracis, Bacillus

Q81WE4, A9VTD5,

anthracis, Bacillus

A7GRM0, B8FT35,

weihenstephanensis, Bacillus

Q24TH1, Q8RH47,

cytotoxicus, Desulfitobacterium

A7GX26, A8Z6P6,

hafniense, Desulfitobacterium

A8ALT6, Q72AR5,

hafniense, Fusobacterium nucleatum,

A1VCU3, B8DPD6,

Campylobacter curvus,

B8J3R3, C5B7M4,

Campylobacter concisus, Citrobacter

Q836V1, Q0TLW5,

koseri, Desulfovibrio vulgaris,

B7UI71, Q1RGH6,

Desulfovibrio vulgaris, Desulfovibrio

Q8FLB7, A1A774,

vulgaris, Desulfovibrio desulfuricans,

B7MNN1, B7MAE6,

Edwardsiella ictaluri, Enterococcus

B1LFV6, B7NHD0,

faecalis, Escherichia coli, Escherichia

B7N7Q0, B1IRE9,

coli, Escherichia coli, Escherichia coli,

B7LVN2, A7ZHB5,

Escherichia coli, Escherichia coli,

B6HZ21, P00956,

Escherichia coli, Escherichia coli,

B1XBF1, C4ZPV2,

Escherichia coli, Escherichia coli,

B7M0C2, B7L4E8,

Escherichia coli, Escherichia

B5YYB8, Q8XA49,

fergusonii, Escherichia coli,

A7ZVX4, Q7VGX8,

Escherichia coli, Escherichia coli,

B5Y235, A9M1J7,

Escherichia coli, Escherichia coli,

Q9JVY4, Q5FAF5,

Escherichia coli, Escherichia coli,

A1KS62, Q9JXY7,

Escherichia coli, Escherichia coli,

B4RPY6, B4F2T5,

Escherichia coli, Helicobacter

P41368, B4SP18,

hepaticus, Klebsiella pneumoniae,

B2FTJ0

Neisseria meningitidis, Neisseria

meningitidis, Neisseria gonorrhoeae,

Neisseria meningitidis, Neisseria

meningitidis, Neisseria gonorrhoeae,

Proteus mirabilis, Staphylococcus

aureus, Stenotrophomonas

maltophilia, Stenotrophomonas

maltophilia

2244
WTTTPWTLPSN

Haemophilus somnus, Haemophilus

Q0I1V8, B8F5E2,
P41252

parasuis, Staphylococcus

Q49WX5, B9DPP7

saprophyticus, Staphylococcus

carnosus

2245
WVEPELRGV

Rhizobium leguminosarum

Q1MHI4
O14782

2246
WVGGRYSLWS

Acinetobacter baumannii

B7IBR9
P06744

2247
WVLGEHGDSS

Lactobacillus delbrueckii

Q04CN9
P00338

2248
WVQIFENKGA

Haemophilus influenzae

P31764
P07902

2249
WYDNEFGYS

Pseudomonas aeruginosa

Q02PG5
P04406

2250
YAEALREVSAA

ptoclostridium difficile

Q184E3
P15313

2251
YAEALREVSAAR

Fusobacterium nucleatum,

Q8RI79, A3DHP1
P15313

Clostridium thermocellum

2252
YARGAQDMK

Campylobacter fetus

A0RNM0
Q03154

2253
YATRDLAAA

Clostridium perfringens, Clostridium

Q8XJU2, A6L573,
Q5T160

beijerinckii, Clostridium botulinum,

B2UW74, B1KYT1,

Clostridium botulinum, Clostridium

Q97K78

acetobutylicum

2254
YATRDLAAAI

Clostridium kluyveri, Clostridium

A5N8F9, B9E1W5,
Q5T160

kluyveri, Clostridium botulinum,

B1I1E6, A7GCB9,

Clostridium botulinum, Clostridium

C1FK28, C3KSZ0,

botulinum, Clostridium botulinum,

A5IQR5, A7FSW7

Clostridium botulinum, Clostridium

botulinurn

2255
YCGFDPTADS

Bacillus caldotenax, Bacillus

P04077, Q6HCM0,
Q9Y2Z4

thuringiensis, Bacillus cereus, Bacillus

Q633D2, Q81KS9,

anthracis, Bacillus cereus, Bacillus

Q72Z73, Q817A2,

cereus, Desulfitobacterium hafniense,

Q251G4, B8G0N6,

Desulfitobacterium hafniense,

A8AH18, A4W9W0,

Citrobacter koseri, Enterobacter sp.,
B7LQN3, B1LEP9,

Escherichia fergusonii, Escherichia

B6IB76, B7NB91,

coli, Escherichia coli, Escherichia coli,

P0AGJ9, B1IQB7,

Escherichia coli, Escherichia coli,

C4ZYA0, A8A010,

Escherichia coli, Escherichia coli,

B1XFU9, B7NTZ5,

Escherichia coli, Escherichia coli,

B5Z471, P0AGK0,

Escherichia coli, Escherichia coli,

A7ZM99, B7M0J4,

Escherichia coli, Escherichia coli,

Q8FH88, B7MVB5,

Escherichia coli, Escherichia coli,

B7L5J0, B7M9Z1,

Escherichia coli, Escherichia coli,

B7URX8, Q1RBF8,

Escherichia coli, Escherichia coli,

A1ABI2, B5XWP0,

Escherichia coli, Klebsiella

A6T9Y5, A9M1J5,

pneumoniae, Klebsiella pneumoniae,

A1KS60, Q9JXY5,

Neisseria meningitidis, Neisseria

Q9JVY6, B4RP13,

meningitidis, Neisseria meningitidis,

Q5FAF7

Neisseria meningitidis, Neisseria

gonorrhoeae, Neisseria gonorrhoeae

2256
YCIVPFTRG

Staphylococcus haemolyticus,

Q4L5Z6, Q8CSS3,
Q965Z6

Staphylococcus epidermidis,

Q5HPP8, Q6GHE3,

Staphylococcus epidermidis,

Q2YXS2, Q7A110,

Staphylococcus aureus,

Q6G951, Q7A5W3,

Staphylococcus aureus,

Q99UI1, A5ISH6,

Staphylococcus aureus,

A6U1B1, A7X1T3,

Staphylococcus aureus,

A8Z1W3, Q2FZ02,

Staphylococcus aureus,

A6QGJ1, Q5HGD9,

Staphylococcus aureus,

Q2FHE6, Q49X85

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus saprophyticus

2257
YCLGPTHEE

Desulfovibrio alaskensis,

Q30Z93, C6BYX7,
Q7L3T8

Desulfovibrio salexigens,

A1VE74, Q72CD8,

Desulfovibrio vulgaris, Desulfovibrio

B8DNM5

vulgaris, Desulfovibrio vulgaris

2258
YCTGGIRCE

Bacillus clausii, Bacillus cereus,

Q5WEM1, B9IX93,
Q5T7W7

Bacillus cereus, Bacillus

B7HMP7, A9VQI6,

weihenstephanensis, Bacillus cereus,

C1EQF9, A0RCP2,

Bacillus thuringiensis, Bacillus

A7GNS3, Q73A25,

cytotoxicus, Bacillus cereus, Bacillus

B7HIR1, Q81F03,

cereus, Bacillus cereus, Bacillus

C3L6L9, C3P778,

anthracis, Bacillus anthracis, Bacillus

B7JJJ3, Q81S00,

cereus, Bacillus anthracis, Bacillus

Q6HK75, Q63CS8,

thuringiensis, Bacillus cereus, Bacillus

B7IS63, Q65EW5,

cereus, Bacillus licheniformis,

Q6NEH3, Q8FLN8,

Corynebacterium diphtheriae,

C3PKD8, Q8NLF0,

Corynebacterium efficiens,

A4QI35, C4LG97,

Corynebacterium aurimucosum,

Q837T2, B2GKC1,

Corynebacterium glutamicum,

Q8Y7A4, B8DFU3,

Corynebacterium glutamicum,

Q71ZT6, C1L2U0,

Corynebacterium kropnstedtii,

A0AII6, Q92BX1,

Enterococcus faecalis, Kocuria

Q4A0W6, B9DJ55,

rhizophila, Listeria monocytogenes,

A6U574, A5IW36,

Listeria monocytogenes, Listeria

P67326, A7X781,

monocytogenes, Listeria

P67327, Q5HCK8,

monocytogenes, Listeria welshimeri,

Q8NUH3, Q6G5Y5,

Listeria innocua, Staphylococcus

Q6GDB5, Q2YZA3,

saprophyticus, Staphylococcus

Q2FUS7, A8Z5J0,

carnosus, Staphylococcus aureus,

Q2FDH2, A6QKH7,

Staphylococcus aureus,

Q4L9R7, Q8CTV8,

Staphylococcus aureus,

Q5HKM8

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus haemolyticus,

Staphylococcus epidermidis,

Staphylococcus epidermidis

2259
YDLTSKPPGT

Eubacterium rectale, Eubacterium

C4ZCQ4, C4Z3X1
P49915

eligens

2260
YDLVLNGNE

Desulfovibrio alaskensis

Q317R3
Q6PI48

2261
YGITTGFGKF

Bacillus methylotrophicus, Bacillus

A7ZAE4, Q9KBE6
P42357

halodurans

2262
YGITTGFGKFA

Fusobacterium nucleatum

Q8RFC2
P42357

2263
YGPPGTGKT

Micrococcus luteus

C5CBU4
Q6PL18

2264
YGPPGVGKT

Bacillus subtilis

P42425
P36776

2265
YGPPGVGKTS

Parabacteroides distasonis,

A6LD45, O69300,
P36776

Campylobacter jejuni, Porphyromonas

B2RI16

gingivalis

2266
YICGEETALI

Escherichia coli

P31979
P49821

2267
YIEAHGTGT

Bacillus subtilis, Bacillus subtilis

Q05470, O31782
P49327

2268
YIGVLIDDL

Bacillus cytotoxicus, Bacillus cereus,

A7GVP6, Q814F7,
Q9Y2Z2

Bacillus cereus, Bacillus

Q72WU4, A9VTL9,

weihenstephanensis, Bacillus

Q6HAF3, Q63069,

thuringiensis, Bacillus cereus, Bacillus

Q81JH3, A0RLR1,

anthracis, Bacillus thuringiensis,

Q040F4, Q74H95,

Lactobacillus gasseri, Lactobacillus

A0AMD1, Q8Y3M5,

johnsonii, Listeria welshimeri, Listeria

Q71VV1, Q926U8,

monocytogenes, Listeria

Q4L2Z3, Q49UI5,

monocytogenes, Listeria innocua,

Q8CMN6, Q5HS35,

Staphylococcus haemolyticus,

Q2YZB9, P64231,

Staphylococcus saprophyticus,

Q6G5W5, Q6GD93,

Staphylococcus epidermidis,

P64230, P64229,

Staphylococcus epidermidis,

A7X7A7, A5IW06,

Staphylococcus aureus,

A6U594, A8YYS0,

Staphylococcus aureus,

A6QKK1, Q5HCI4,

Staphylococcus aureus,

Q2FUQ3, Q2FDE9

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus,

Staphylococcus aureus

2269
YINSPGGWT

Arcobacter butzleri, Campylobacter

A8EVH5, B9KDZ6,
Q16740

lari, Campylobacter hominis,

A7HZE8, Q982V6,

Rhizobium loti, Rhizobium loti

Q98M38

2270
YINSPGGWTAG

Rhizobium etli, Rhizobium

Q2K9U7, Q1MIM7,
Q16740

leguminosarum, Rhizobium meliloti

P58278

2271
YINSPGGWTAGL

Haemophilus ducreyi

Q7VP78
Q16740

AIYDTM

2272
YITPVPGGVGPMT

Bacteroides vulgatus,

A6L2G2, A6L8J2,
P13995

Parabacteroides distasonis,

Q0PA35, A8FLR4,

Campylobacter jejuni, Campylobacter

A1VZJ8, Q5HUU1,

jejuni, Campylobacter jejuni,

Q7MVE9

Campylobacter jejuni, Porphyromonas

gingivalis

2273
YLDLYLIHWP

Bacillus subtilis, Bacillus subtilis

O34678, O32210
Q96JD6

2274
YLRPETAQGIF

Eubacterium rectale, Bifidobacterium

C4ZAV7, Q8G7W9,
P41250

longum, Clostridium kluyveri,

A5N4L2, B9DY74,

Clostridium kluyveri, Clostridium

Q97EB8, Q8XHL9,

acetobutylicum, Clostridium

A9KJ36, A6LPL6,

perfringens, Clostridium

B8I2Z6, A3DF15,

phytofermentans, Clostridium

Q8FNG6, Q8NNC6,

eijerinckii, Clostridium cellulolyticum,

C4Z1I4, Q6A964,

Clostridium thermocellum,

Q9L2H9, Q82BR9

Corynebacterium efficiens,

Corynebacterium glutamicum,

Eubacterium eligens,

Propionibacterium acnes,

Streptomyces coelicolor,

Streptomyces avermitilis

2275
YLVMEYVPG

Bacillus anthracis

Q81WH6
P22612

2276
YNKDLQEDKE

Lactobacillus plantarum, Lactobacillus

P59617, B2GE78,
P04424

fermentum, Lactobacillus salivarius,

Q1WV66, C1KX44,

Listeria monocytogenes, Listeria

Q71XS3, B8DH27,

monocytogenes, Listeria

Q8Y5H1, Q929S8,

monocytogenes, Listeria

A0AKJ8, Q8DVX5,

monocytogenes, Listeria innocua,

B9DW8, Q03IP9,

Listeria welshimeri, Streptococcus

Q5M2K3, Q5LXZ9,

mutans, Streptococcus uberis,

A3CQQ3, A8AUN7,

Streptococcus thermophilus,

C1CAC7, C1CBS9,

Streptococcus thermophilus,

Q8DRI4, B1I815,

Streptococcus thermophilus,

Q04MW6, Q8E271,

Streptococcus sanguinis,

Q3K3Q3, Q8E7N0

Streptococcus gordonii,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus pneumoniae,

Streptococcus agalactiae,

Streptococcus agalactiae,

Streptococcus agalactiae

2277
YPLNPNGSP

Ralstonia solanacearum

Q8XYN6
O15067

2278
YQDQKPGTSGLR

Rhizobium radiobacter

P39671
P36871

K

2279
YQIYPRSFKD

Streptococcus dysgalactiae

Q59905
Q07837

2280
YQIYPRSFKDSN

Bacillus subtilis

O05242
Q07837

2281
YQRLEFLGD

Leuconostoc mesenteroides,

Q03VW5, B1N016,
Q9UPY3

Leuconostoc citreum, Rhizobium sp.,
C3M854, Q92R47

Rhizobium meliloti

2282
YQWYLDLRR

Lactobacillus sakei

Q38X65
Q96159

2283
YRDDGLLVW

Pseudomonas aeruginosa,

Q9I4G8, Q8RNT4
P09917

Pseudomonas aeruginosa

2284
YRIDHYLGKE

Escherichia coli, Escherichia coli,

O8XCJ6, P0AC53,
P11413

Escherichia coli

P0AC54

2285
YRKLALKYHPD

Helicobacter pylori, Helicobacter

O25890, Q9ZJQ2
Q8WW22

pylori

2286
YRLALQTREQHIR

Ralstonia pickettii, Ralstonia

B2UG82, Q8XU98
P23378

R

solanacearum

2287
YRLALQTREQHIR

Rhizobium loti

Q98LT6
P23378

RDKATSNICTAQA

LLANMA

2288
YRQRYLDLI

Lactobacillus plantarum, Lactobacillus

Q88Z28, B2GA78,
Q15046

fermentum, Lactobacillus sakei,

Q38V83, Q03E09

Pediococcus ntosaceus

2289
YSALKKDGQ

Pseudomonas aeruginosa,

A6VCJ9, P72154,
Q8WWH5

Pseudomonas aeruginosa,

Q02FT0, A4XYD8

Pseudomonas aeruginosa,

Pseudomonas mendocina

2290
YSAVNQGHCHPKI

Bacillus halodurans

Q9K5Z2
P04181

2291
YTAIEAPKGE

Geobacter uraniireducens

A5GCZ4
O75306

2292
YTHFTSPIRR

Bacillus subtilis, Helicobacter pylori,

O32231, P56123,
Q8IYB7

Helicobacter pylori

Q9ZJX9

2293
YTPYQPEVSQGR

Citrobacter koseri, Edwardsiella

A8APB1, C5BAT0,
P23378

LE

ictaluri, Enterobacter sp., Escherichia
A4WE55, Q1R7C8,

coli, Escherichia coli, Escherichia coli,

B7MZ55, B7MM89,

Escherichia coli, Escherichia coli,

B7UHV1, Q0TDU9,

Escherichia coli, Escherichia coli,

B7LYG7, A7ZR12,

Escherichia coli, Escherichia coli,

Q8FE67, B7N7E6,

Escherichia coli, Escherichia coli,

B7NHW4, B1LDA3,

Escherichia coli, Escherichia coli,

A1AF92, Q8XD33,

Escherichia coli, Escherichia

B5YQ95, B7LPB7,

fergusonii, Escherichia coli,

P33195, C5A0H5,

Escherichia coli, Escherichia coli,

B1XEJ0, B61736,

Escherichia coli, Escherichia coli,

A8A444, B7LF89,

Escherichia coli, Escherichia coli

B1IT99

2294
YTPYQPEVSQGR

Klebsiella pneumoniae, Klebsiella

A6TDR5, B5XUD5,
P23378

LESLLN

pneumoniae, Proteus mirabilis

B4F0N7

2295
YTRREPLGVC

Rhizobium meliloti

Q92YD2
P49189

2296
YTSGSTGKPKGV

Aneurinibacillus migulanus, Bacillus

P00063, P39847,
Q9NR19

subtilis, Bacillus subtilis, Bacillus

Q9R9I9, Q04747,

subtilis, Bacillus subtilis, Bacillus

Q9R9J0, P40806

subtilis

2297
YTSGSTGMPKG

Bacillus licheniformis, Bacillus subtilis

O68008, P94459
Q9NUB1

2298
YTSGSTGRPKGV

Bacillus subtilis, Streptomyces niveus

P45745, Q9L9G0
O60488

2299
YTSGTTGLPKG

Pseudomonas sp.
A5JTM6
Q9H6R3

2300
YTSGTTGNPKG

Aneurinibacillus migulanus

P00061
Q96GR2

2301
YTSGTTGNPKGV

Pseudomonas oleovorans

Q00594
Q96GR2

2302
YTSGTTGNPKGV

Bacillus licheniformis

Q68007
Q96GR2

M

2303
YTSVLKRAI

Citrobacter koseri, Edwardsiella

A8AJ40, C5BEL3,
P15259

ictaluri, Enterobacter sp., Escherichia
A4W897, P62708,

coli, Escherichia coli, Escherichia coli,

B7N9Z7, B7NNH7,

Escherichia coli, Escherichia coli,

B1LM46, B7M6B8,

Escherichia coli, Escherichia

P62707, B7LK04,

fergusonii, Escherichia coli,

B617Q9, Q0TJU6,

Escherichia coli, Escherichia coli,

B1X786, B5YRF2,

Escherichia coli, Escherichia coli,

B7MPN9, A7ZY11,

Escherichia coli, Escherichia coli,

B1IXY1, B7LAF6,

Escherichia coli, Escherichia coli,

P62709, C4ZXS6,

Escherichia coli, Escherichia coli,

A1A8Z8, B7MGL2,

Escherichia coli, Escherichia coli,

B7ULM8, A7ZJD0,

Escherichia coli, Geobacter

Q39V40, B5XZB2,

metallireducens, Klebsiella

A6T6I3, B4EST0,

pneumoniae, Klebsiella pneumoniae,

Q03KA9, Q8VVB5,

Proteus mirabilis, Streptococcus

Q5LZF1, C1C8P5,

thermophilus, Streptococcus

C1CFM7, P0A3Y4,

thermophilus, Streptococcus

P0A3Y3, B1I720,

thermophilus, Streptococcus

B5E706, Q04JB4,

pneumoniae, Streptococcus

A3CLS0, C1CLZ5,

pneumoniae, Streptococcus

B8ZM52, C1CSS1,

pneumoniae, Streptococcus

B2IRR1, A8AW46,

pneumoniae, Streptococcus

B1GZZ1

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

sanguinis, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus

pneumoniae, Streptococcus gordonii,

Uncultured termite

2304
YTSVLKRAIRTL

Clostridium acetobutylicum

Q97FJ6
P15259

2305
YTSVLKRAIRTLW

Bacillus cereus, Bacillus cereus,

Q737X5, Q81DD2,
P15259

Bacillus cereus, Bacillus cereus,

B7IX37, B9J102,

Bacillus cereus, Bacillus cereus,

B7H546, B7H7P4,

Bacillus anthracis, Bacillus anthracis,

Q6KSL4, C3PAW8,

Bacillus anthracis, Bacillus cereus,

C3LIE5, B7JPK2,

Bacillus cereus, Bacillus thuringiensis,

Q63692, A0RE96,

Bacillus cereus, Bacillus thuringiensis,

C1EUQ5, Q6HIL9,

Bacillus cytotoxicus, Bacillus

A7GPN5, A9VFW9,

weihenstephanensis, Clostridium

A6LUA1, Q8Y2I3

beijerinckii, Ralstonia solanacearum

2306
YVEGESLLM

Pseudomonas putida, Pseudomonas

B1JDR3, Q1IEJ2,
Q9Y697

entomophila, Pseudomonas putida,

Q88PK8, A5VYS4,

Pseudomonas putida, Pseudomonas

B0KPH6

putida

2307
YVGCGERGNEM

Enterococcus faecalis

Q834X9
P38606

2308
YVHRIGRTGR

Aeromonas hydrophila, Aeromonas

A0KEG9, A4STJ7,
Q9UJV9

salmonicida, Citrobacter koseri,

A8ACT3, A4WG30,

Enterobacter sp., Escherichia coli,
P25888, B5YY28,

Escherichia coli, Escherichia coli,

Q8XAT4, B7LU75,

Escherichia fergusonii, Escherichia

B7NTG2, P0A8J8,

coli, Escherichia coli, Escherichia coli,

Q1R4F9, B6I4B6,

Escherichia coli, Escherichia coli,

C4ZZ48, B1IWC0,

Escherichia coli, Escherichia coli,

Q0TAU3, P0A8J9,

Escherichia coli, Escherichia coli,

A1AHV0, A8A6N4,

Escherichia coli, Escherichia coli,

B1X9Z4, B7M5C7,

Escherichia coli, Escherichia coli,

B7MR01, B7L8B6,

Escherichia coli, Escherichia coli,

A7ZTY2, B7MGJ1,

Escherichia coli, Escherichia coli,

B7UMN5, B7NF85,

Escherichia coli, Escherichia coli,

B1LLV3, Q8XA87,

Escherichia coli, Escherichia coli,

P0A9P6, P0A9P7,

Escherichia coli, Haemophilus

Q0I1X0, P44586,

somnus, Haemophilus influenzae,

A5UI36, P44922,

Haemophilus influenzae,

A5UDI1, A6TGG9,

Haemophilus influenzae,

B5XYY9, P33906,

Haemophilus influenzae, Klebsiella

B4F1V3

pneumoniae, Klebsiella pneumoniae,

Klebsiella pneumoniae, Proteus

mirabilis

2309
YVHRVGRTARAG

Bacillus subtilis

P54475
Q8N8A6

2310
YVNDAFGTAHRA

Bacteroides thetaiotaomicron,

Q8A753, Q7MU77
P07205

H

Porphyromonas gingivalis

2311
YVYIIYGMY

Clostridium perfringens, Clostridium

Q8XHA9, Q0SPY0,
P29372

perfringens, Clostridium perfringens

Q0TM75

2312
YWHFVDWW

Corynebacterium diphtheriae,

Q6NGA0, Q9AEL8,
P00414

Corynebacterium glutamicum,

Q8FN09, Q9X809,

Corynebacterium efficiens,

Q82AK5

Streptomyces coelicolor,

Streptomyces avermitilis

2313
YWLSGLTCTEQN

Haemophilus influenzae

P44556
P10768

FI

TABLE 2

Nucleic acid sequences encoding drug-metabolizing gene products (identified by start

nucleotide and end nucleotide in the listed contigs in the mentioned bacterial species,

as disclosed in Zimmermann et al. (2019) Nature 570(7762): 462-467).

NCBI_NUCCORE_ID
SPECIES
START
END

CVOZ01000027.1

Bacteroides thetaiotaomicron

37953
39176

CVOZ01000054.1

Bacteroides thetaiotaomicron

11293
10091

CVOZ01000070.1

Bacteroides thetaiotaomicron

209
1357

JGCP01002329.1

Bacteroides fragilis

4469
5122

JGCP01002329.1

Bacteroides fragilis

3779
5098

NC_000913.3

Escherichia coli

4581453
4580197

NC_009614.1

Bacteroides vulgatus

4257974
4256682

NC_009614.1

Bacteroides vulgatus

4556425
4555544

NC_012781.1

Eubacterium rectale

2288771
2288262

NC_012781.1

Eubacterium rectale

784939
786126

NC_012781.1

Eubacterium rectale

1283259
1283786

NZ_AAVM02000005.1

Bacteroides caccae

114685
114182

NZ_ACEP01000037.1

Eubacterium hallii

7170
8357

NZ_DS264584.1

Bacteroides ovatus

814601
813570

NZ_DS544184.1

Anaerotruncus colihominis

120271
119024

NZ_DS544185.1

Anaerotruncus colihominis

210646
210155

NZ_DS981517.1

Clostridium sporogenes

1624155
1624691

NZ_DS981517.1

Clostridium sporogenes

2067986
2066751

NZ_DS990240.1

Bifidobacterium longum

215669
216163

NZ_DS995528.1

Bacteroides dorei

145200
143932

NZ_DS995531.1

Bacteroides dorei

422777
421590

NZ_DS996451.1

Parabacteroides johnsonii

204827
205366

NZ_DS996841.1

Holdemanella biformis

520281
520754

NZ_DS996921.1

Bacteroides pectinophilus

1435212
1434652

NZ_GG667612.1

Hungatella hathewayi

20416
21654

NZ_GG703853.1

Prevotella copri

461595
462476

NZ_GG739634.1

Edwardsiella tarda

123662
122379

NZ_JH370372.1

Alistipes indistinctus

576953
575652

NZ_JH724294.1

Bacteroides xylanisolvens

756855
758042

NZ_MTWC01000003.1

Clostridioides difficile

3445824
3444499

NZ_MTWF01000021.1

Clostridioides difficile

518815
517457

NZ_PPUH01000002.1

Eggerthella lenta

280904
279747

NZ_PUEP01000005.1

Bacteroides ovatus

2631144
2632175

NZ_PUEQ01000002.1

Bacteroides caccae

481569
481066

QEKH01000037.1

Victivallis vadensis

16258
17517

QEKH01000037.1

Victivallis vadensis

16252
16887

CVOZ01000028.1

Bacteroides thetaiotaomicron

3250
2549

CVOZ01000054.1

Bacteroides thetaiotaomicron

13292
11376

JGCP01000504.1

Bacteroides fragilis

6097
5297

JGCP01002329.1

Bacteroides fragilis

1730
3721

NC_000913.3

Escherichia coli

4582670
4581897

NC_009614.1

Bacteroides vulgatus

4260288
4258765

NC_009614.1

Bacteroides vulgatus

4559064
4558243

NC_009614.1

Bacteroides vulgatus

5131510
5130809

NC_009614.1

Bacteroides vulgatus

4258359
4258033

NC_010655.1

Akkermansia muciniphila

2326675
2325422

NC_012781.1

Eubacterium rectale

1280802
1282049

NC_012781.1

Eubacterium rectale

783803
784687

NC_012781.1

Eubacterium rectale

2289989
2289360

NZ_AAVM02000001.1

Bacteroides caccae

205035
205766

NZ_AAVM02000001.1

Bacteroides caccae

203504
204244

NZ_AAVM02000004.1

Bacteroides caccae

19818
20552

NZ_AAVM02000004.1

Bacteroides caccae

18226
19026

NZ_AAVM02000005.1

Bacteroides caccae

117790
117089

NZ_AAVN02000002.1

Collinsella aerofaciens

214688
215971

NZ_AAVN02000005.1

Collinsella aerofaciens

3193
3990

NZ_ABJL02000008.1

Bacteroides intestinalis

2255438
2256781

NZ_ACEP01000015.1

Eubacterium hallii

5220
6134

NZ_ACEP01000037.1

Eubacterium hallii

5395
6828

NZ_ACEP01000037.1

Eubacterium hallii

6874
7077

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

568907
569809

NZ_ATFI01000010.1

Bacteroides cellulosilyticus

71257
72078

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

54384
55085

NZ_CVOY01000006.1

Bacteroides thetaiotaomicron

52086
51364

NZ_DS264518.1

Parabacteroides merdae

16658
15375

NZ_DS264540.1

Parabacteroides merdae

361593
360295

NZ_DS264579.1

Bacteroides ovatus

224414
223701

NZ_DS264583.1

Bacteroides ovatus

46086
45352

NZ_DS264583.1

Bacteroides ovatus

47678
46878

NZ_DS264584.1

Bacteroides ovatus

815730
814999

NZ_DS362241.1

Bacteroides uniformis

196137
195403

NZ_DS362241.1

Bacteroides uniformis

197729
196929

NZ_DS480690.1

Clostridium bolteae

323991
322990

NZ_DS480691.1

Clostridium bolteae

78208
77450

NZ_DS499657.1

Erysipelatoclostridium ramosum

178202
178987

NZ_DS499711.1

Clostridium scindens

60639
59893

NZ_DS499717.1

Clostridium scindens

8080
8883

NZ_DS544184.1

Anaerotruncus colihominis

122241
120328

NZ_DS544185.1

Anaerotruncus colihominis

208987
208256

NZ_DS562851.1

Clostridium spiroforme

122136
120808

NZ_DS607662.1

Providencia stuartii

136152
134944

NZ_DS607663.1

Providencia stuartii

2255207
2254365

NZ_DS981517.1

Clostridium sporogenes

2070130
2068076

NZ_DS981517.1

Clostridium sporogenes

1625390
1626655

NZ_DS990167.1

Ruminococcus lactaris

53930
53016

NZ_DS990240.1

Bifidobacterium longum

218706
219962

NZ_DS995528.1

Bacteroides dorei

147185
145257

NZ_DS995531.1

Bacteroides dorei

416684
417385

NZ_DS995533.1

Bacteroides dorei

155441
156262

NZ_DS995537.1

Bacteroides dorei

1437808
1436660

NZ_DS996451.1

Parabacteroides johnsonii

207952
208764

NZ_DS996456.1

Parabacteroides johnsonii

108659
107847

NZ_DS996456.1

Parabacteroides johnsonii

110251
109451

NZ_DS996841.1

Holdemanella biformis

530223
529429

NZ_DS996842.1

Holdemanella biformis

261013
259934

NZ_DS996921.1

Bacteroides pectinophilus

1430841
1431722

NZ_EQ973491.1

Bacteroides cellulosilyticus

1154297
1153236

NZ_EQ973628.1

Bacteroides coprophilus

87118
88245

NZ_EQ973632.1

Bacteroides coprophilus

313579
314352

NZ_GG661996.1

Proteus penneri

1167486
1168580

NZ_GG688317.1

Bacteroides finegoldii

348015
347215

NZ_GG688317.1

Bacteroides finegoldii

346423
345689

NZ_GG688319.1

Bacteroides finegoldii

253543
252737

NZ_GG688335.1

Bacteroides finegoldii

35726
34782

NZ_GG693680.1

Lactobacillus reuteri

26256
25393

NZ_GG698591.1

Blautia hansenii

55695
54289

NZ_GG703853.1

Prevotella copri

460179
461117

NZ_GG703856.1

Prevotella copri

196695
195994

NZ_GG704769.1

Subdoligranulum variabile

1915102
1914251

NZ_GG704769.1

Subdoligranulum variabile

716466
715603

NZ_GG704770.1

Subdoligranulum variabile

46083
47042

NZ_GG704863.1

Enterobacter cancerogenus

307779
308621

NZ_GG705268.1

Providencia rettgeri

11845
12723

NZ_GG729831.1

Bifidobacterium breve

488254
489387

NZ_GG739634.1

Edwardsiella tarda

126001
124481

NZ_JDUD01000001.1

Bifidobacterium breve

1961
828

NZ_JH370372.1

Alistipes indistinctus

579365
577842

NZ_JH724294.1

Bacteroides xylanisolvens

755593
756279

NZ_KB946519.1

Enterococcus faecalis

1804247
1803225

NZ_MTWC01000003.1

Clostridioides difficile

3447851
3445902

NZ_MTWF01000021.1

Clostridioides difficile

520833
518884

NZ_PPUH01000002.1

Eggerthella lenta

282952
281126

NZ_PPUH01000003.1

Eggerthella lenta

250182
248503

NZ_PUEM01000006.1

Clostridium bolteae

1494991
1494233

NZ_PUEM01000006.1

Clostridium bolteae

4993617
4992616

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1484088
1484909

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1462828
1463529

NZ_PUEP01000005.1

Bacteroides ovatus

2630015
2630746

NZ_PUEP01000005.1

Bacteroides ovatus

458680
459414

NZ_PUEP01000005.1

Bacteroides ovatus

457088
457888

NZ_PUEP01000005.1

Bacteroides ovatus

4797484
4798197

NZ_PUEQ01000002.1

Bacteroides caccae

484674
483973

NZ_PUEQ01000003.1

Bacteroides caccae

2030655
2029921

NZ_PUEQ01000003.1

Bacteroides caccae

2032247
2031447

NZ_PUEQ01000003.1

Bacteroides caccae

3827059
3827790

NZ_PUEQ01000003.1

Bacteroides caccae

3825528
3826268

NZ_UFTH01000001.1

Bacteroides fragilis

4093184
4094062

NZ_UFTH01000001.1

Bacteroides fragilis

3280562
3281596

NZ_UFTH01000001.1

Bacteroides fragilis

1493809
1494609

QEKH01000037.1

Victivallis vadensis

13374
15320

QEKH01000048.1

Victivallis vadensis

3497
2508

CVOZ01000035.1

Bacteroides thetaiotaomicron

106949
108160

CVOZ01000043.1

Bacteroides thetaiotaomicron

27888
26839

JGCP01002172.1

Bacteroides fragilis

2
874

JGCP01002354.1

Bacteroides fragilis

7402
8451

JGCP01002545.1

Bacteroides fragilis

3274
4485

NC_000913.3

Escherichia coli

425011
426039

NC_009614.1

Bacteroides vulgatus

486915
488129

NC_009614.1

Bacteroides vulgatus

1587181
1588227

NC_009615.1

Parabacteroides distasonis

4582216
4581011

NC_009615.1

Parabacteroides distasonis

2819035
2817989

NC_010655.1

Akkermansia muciniphila

843027
842053

NC_012781.1

Eubacterium rectale

1870731
1869694

NZ_AAVM02000002.1

Bacteroides caccae

264921
265970

NZ_AAVM02000003.1

Bacteroides caccae

71289
70078

NZ_AAVN02000005.1

Collinsella aerofaciens

180699
181904

NZ_AAXA02000015.1

Dorea formicigenerans

155473
154451

NZ_AAYG02000031.1

Ruminococcus gnavus

76269
75247

NZ_ABJL02000001.1

Bacteroides intestinalis

248746
247526

NZ_ABJL02000007.1

Bacteroides intestinalis

194759
193713

NZ_ABXA01000019.1

Anaerococcus hydrogenalis

158102
157086

NZ_ABXW01000004.1

Providencia alcalifaciens

121941
122987

NZ_ACCL02000019.1

Marvinbryantia formatexigens

57650
56628

NZ_ACEP01000009.1

Eubacterium hallii

16113
17132

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1098277
1099323

NZ_ATFI01000006.1

Bacteroides cellulosilyticus

233208
231988

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

140399
141610

NZ_CVOY01000046.1

Bacteroides thetaiotaomicron

28312
27263

NZ_DS264284.1

Eubacterium ventriosum

217372
216347

NZ_DS264382.1

Ruminococcus torques

70803
71837

NZ_DS264476.1

Parabacteroides merdae

37736
38782

NZ_DS264542.1

Parabacteroides merdae

311126
312331

NZ_DS264579.1

Bacteroides ovatus

416778
417827

NZ_DS264584.1

Bacteroides ovatus

16717
15506

NZ_DS362235.1

Bacteroides uniformis

56952
57998

NZ_DS362247.1

Bacteroides uniformis

304752
303532

NZ_DS480669.1

Clostridium bolteae

257651
256632

NZ_DS499656.1

Erysipelatoclostridium ramosum

69655
68633

NZ_DS499674.1

Bacteroides stercoris

260486
259440

NZ_DS499677.1

Bacteroides stercoris

230155
231375

NZ_DS499718.1

Clostridium scindens

28492
29511

NZ_DS544183.1

Anaerotruncus colihominis

144332
145372

NZ_DS562852.1

Clostridium spiroforme

49724
48702

NZ_DS607683.1

Providencia stuartii

179065
180096

NZ_DS981517.1

Clostridium sporogenes

618670
619701

NZ_DS990170.1

Ruminococcus lactaris

184161
183127

NZ_DS995508.1

Bacteroides eggerthii

169795
168575

NZ_DS995511.1

Bacteroides eggerthii

462444
461398

NZ_DS995528.1

Bacteroides dorei

148712
147498

NZ_DS995534.1

Bacteroides dorei

439390
440436

NZ_DS996452.1

Parabacteroides johnsonii

143947
142901

NZ_DS996453.1

Parabacteroides johnsonii

157487
156282

NZ_DS996921.1

Bacteroides pectinophilus

1049700
1050290

NZ_DS996921.1

Bacteroides pectinophilus

1050286
1050726

NZ_EQ973489.1

Bacteroides cellulosilyticus

174147
172927

NZ_EQ973490.1

Bacteroides cellulosilyticus

1290447
1291493

NZ_EQ973631.1

Bacteroides coprophilus

94724
93663

NZ_EQ973650.1

Bacteroides coprophilus

219067
217853

NZ_GG657592.1

Clostridium asparagiforme

3244881
3245795

NZ_GG661996.1

Proteus penneri

808745
807888

NZ_GG662010.1

Coprococcus comes

66418
65384

NZ_GG667675.1

Hungatella hathewayi

10370
9345

NZ_GG688318.1

Bacteroides finegoldii

209328
210539

NZ_GG688332.1

Bacteroides finegoldii

112379
113428

NZ_GG692710.1

Collinsella intestinalis

58740
59960

NZ_GG692730.1

Roseburia intestinalis

17297
16278

NZ_GG698588.1

Blautia hansenii

858259
857240

NZ_GG703852.1

Prevotella copri

471774
470506

NZ_GG703861.1

Prevotella copri

82450
83631

NZ_GG704769.1

Subdoligranulum variabile

943449
944462

NZ_GG704864.1

Enterobacter cancerogenus

124853
125881

NZ_GG705265.1

Providencia rettgeri

180250
179204

NZ_GG739633.1

Edwardsiella tarda

362637
363656

NZ_JGDE01000005.1

Bacteroides fragilis

6231
7280

NZ_JGDE01000133.1

Bacteroides fragilis

92211
93422

NZ_JH370371.1

Alistipes indistinctus

1466197
1467243

NZ_JH370372.1

Alistipes indistinctus

467211
466027

NZ_JH724294.1

Bacteroides xylanisolvens

201312
200101

NZ_JH724295.1

Bacteroides xylanisolvens

740942
741991

NZ_KB946519.1

Enterococcus faecalis

432320
433351

NZ_MTWC01000003.1

Clostridioides difficile

3052895
3051876

NZ_MTWD01000001.1

Clostridioides difficile

3067290
3066271

NZ_MTWE01000004.1

Clostridioides difficile

2778929
2777910

NZ_MTWF01000021.1

Clostridioides difficile

126336
125317

NZ_NSBZ01000002.1

Salmonella enterica

338306
337332

NZ_PPUH01000003.1

Eggerthella lenta

25535
26617

NZ_PUEL01000004.1

Ruminococcus gnavus

1103873
1102851

NZ_PUEM01000006.1

Clostridium bolteae

5515992
5514973

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

1074907
1075956

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

699930
698719

NZ_PUEP01000005.1

Bacteroides ovatus

3429039
3430250

NZ_PUEP01000005.1

Bacteroides ovatus

4605120
4604071

NZ_PUEQ01000003.1

Bacteroides caccae

2633686
2634897

NZ_PUEQ01000003.1

Bacteroides caccae

3356989
3355940

NZ_UFTH01000001.1

Bacteroides fragilis

1051923
1053134

NZ_UFTH01000001.1

Bacteroides fragilis

2014558
2015607

QEKH01000016.1

Victivallis vadensis

92415
91372

BACDOR_03988

41
204

BT_1148

7
170

CVOZ01000016.1

Bacteroides thetaiotaomicron

104209
104940

JGCP01000803.1

Bacteroides fragilis

3204
3473

JGCP01002532.1

Bacteroides fragilis

1981
1532

JGCP01002542.1

Bacteroides fragilis

44107
43376

NC_000913.3

Escherichia coli

891196
891777

NC_008618.1

Bifidobacterium adolescentis

1983240
1983764

NC_009614.1

Bacteroides vulgatus

2241
1504

NC_009614.1

Bacteroides vulgatus

2553354
2553839

NC_009614.1

Bacteroides vulgatus

3238578
3238018

NC_009615.1

Parabacteroides distasonis

2501051
2500311

NC_009615.1

Parabacteroides distasonis

185234
184725

NC_009615.1

Parabacteroides distasonis

2044489
2044971

NZ_AAVM02000007.1

Bacteroides caccae

111194
111931

NZ_AAVN02000007.1

Collinsella aerofaciens

68266
68859

NZ_ABJL02000002.1

Bacteroides intestinalis

102975
102244

NZ_ABJL02000008.1

Bacteroides intestinalis

2984894
2985385

NZ_ACCL02000001.1

Marvinbryantia formatexigens

116314
117015

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

389871
390449

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

572171
572635

NZ_ATFI01000006.1

Bacteroides cellulosilyticus

367144
367875

NZ_CVOY01000001.1

Bacteroides thetaiotaomicron

257803
258534

NZ_DS264285.1

Eubacterium ventriosum

123016
122507

NZ_DS264518.1

Parabacteroides merdae

27196
27927

NZ_DS264580.1

Bacteroides ovatus

292879
293613

NZ_DS362242.1

Bacteroides uniformis

188956
188219

NZ_DS480690.1

Clostridium bolteae

89580
90023

NZ_DS499655.1

Erysipelatoclostridium ramosum

354524
355015

NZ_DS499676.1

Bacteroides stercoris

475435
474704

NZ_DS499697.1

Clostridium scindens

281706
282383

NZ_DS499697.1

Clostridium scindens

325343
325786

NZ_DS562853.1

Clostridium spiroforme

140563
141048

NZ_DS981517.1

Clostridium sporogenes

1671563
1672027

NZ_DS981518.1

Clostridium sporogenes

524044
524577

NZ_DS990198.1

Ruminococcus lactaris

16800
16285

NZ_DS990242.1

Bifidobacterium longum

122060
122794

NZ_DS995508.1

Bacteroides eggerthii

209488
210219

NZ_DS995531.1

Bacteroides dorei

345468
346205

NZ_DS995536.1

Bacteroides dorei

38613
38128

NZ_DS995537.1

Bacteroides dorei

674814
674254

NZ_DS996446.1

Parabacteroides johnsonii

59128
59640

NZ_DS996456.1

Parabacteroides johnsonii

45966
45229

NZ_DS996844.1

Holdemanella biformis

9201
9803

NZ_DS996847.1

Holdemanella biformis

35961
36455

NZ_EQ973489.1

Bacteroides cellulosilyticus

369930
370583

NZ_EQ973491.1

Bacteroides cellulosilyticus

190366
189788

NZ_EQ973651.1

Bacteroides coprophilus

153905
154642

NZ_GG657595.1

Clostridium asparagiforme

13750
13313

NZ_GG662012.1

Coprococcus comes

43441
42917

NZ_GG688321.1

Bacteroides finegoldii

291692
290958

NZ_GG688334.1

Bacteroides finegoldii

50704
51141

NZ_GG692710.1

Collinsella intestinalis

1194654
1194136

NZ_GG692723.1

Roseburia intestinalis

45135
44680

NZ_GG693679.1

Lactobacillus reuteri

97
633

NZ_GG698590.1

Blautia hansenii

424867
424271

NZ_GG703854.1

Prevotella copri

357269
358000

NZ_GG704774.1

Subdoligranulum variabile

1827
2453

NZ_GG704863.1

Enterobacter cancerogenus

397917
398492

NZ_GG729831.1

Bifidobacterium breve

6677
5940

NZ_GG739633.1

Edwardsiella tarda

1759109
1758594

NZ_JGDE01000133.1

Bacteroides fragilis

56983
56252

NZ_JH370371.1

Alistipes indistinctus

1207458
1206736

NZ_JH370372.1

Alistipes indistinctus

265973
265428

NZ_JH724296.1

Bacteroides xylanisolvens

301016
300282

NZ_KB946519.1

Enterococcus faecalis

784642
784046

NZ_KE136402.1

Enterococcus faecalis

2316901
2317497

NZ_MTWC01000003.1

Clostridioides difficile

183069
182566

NZ_MTWD01000001.1

Clostridioides difficile

272104
271601

NZ_PUEL01000004.1

Ruminococcus gnavus

423569
423006

NZ_PUEM01000006.1

Clostridium bolteae

4759212
4759655

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

338541
339272

NZ_PUEP01000005.1

Bacteroides ovatus

562285
561656

NZ_PUEP01000015.1

Bacteroides ovatus

146479
147213

NZ_PUEQ01000003.1

Bacteroides caccae

349059
349796

NZ_UFTH01000001.1

Bacteroides fragilis

1012777
1012046

NZ_UFTH01000001.1

Bacteroides fragilis

627434
626985

QEKH01000020.1

Victivallis vadensis

35006
35443

BT_0569

32
234

BT_4075

37
107

BT_4096

1
225

CVOZ01000053.1

Bacteroides thetaiotaomicron

57242
56634

JGCP01000996.1

Bacteroides fragilis

438
7

JGCP01001374.1

Bacteroides fragilis

8889
9464

JGCP01002361.1

Bacteroides fragilis

711
136

JGCP01002366.1

Bacteroides fragilis

7394
6798

JGCP01002441.1

Bacteroides fragilis

9814
10422

JGCP01002459.1

Bacteroides fragilis

103650
103045

JGCP01002552.1

Bacteroides fragilis

31137
31757

NC_009614.1

Bacteroides vulgatus

5100333
5099671

NC_009615.1

Parabacteroides distasonis

1135108
1135623

NC_010655.1

Akkermansia muciniphila

28365
28967

NZ_AAVM02000001.1

Bacteroides caccae

1240830
1240231

NZ_AAVM02000003.1

Bacteroides caccae

380349
379744

NZ_AAYG02000020.1

Ruminococcus gnavus

146583
146029

NZ_ABJL02000006.1

Bacteroides intestinalis

363926
364525

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

142507
143106

NZ_CVOY01000005.1

Bacteroides thetaiotaomicron

209440
210048

NZ_DS264582.1

Bacteroides ovatus

46715
46128

NZ_DS362220.1

Bacteroides uniformis

323248
322721

NZ_DS362220.1

Bacteroides uniformis

17094
16558

NZ_DS362233.1

Bacteroides uniformis

68137
68724

NZ_DS362246.1

Bacteroides uniformis

117769
117260

NZ_DS480679.1

Clostridium bolteae

119727
120254

NZ_DS499674.1

Bacteroides stercoris

577837
577238

NZ_DS562848.1

Clostridium spiroforme

372214
372744

NZ_DS995510.1

Bacteroides eggerthii

656723
657343

NZ_DS995511.1

Bacteroides eggerthii

728361
727798

NZ_DS995531.1

Bacteroides dorei

447813
448475

NZ_DS996921.1

Bacteroides pectinophilus

466835
467326

NZ_EQ973490.1

Bacteroides cellulosilyticus

257404
258003

NZ_EQ973490.1

Bacteroides cellulosilyticus

916552
917088

NZ_GG657592.1

Clostridium asparagiforme

3235183
3234566

NZ_GG688322.1

Bacteroides finegoldii

129579
130202

NZ_GG692731.1

Roseburia intestinalis

64242
63706

NZ_GG704769.1

Subdoligranulum variabile

1963367
1962822

NZ_JGDE01000016.1

Bacteroides fragilis

30454
29879

NZ_JGDE01000017.1

Bacteroides fragilis

7455
6859

NZ_JGDE01000072.1

Bacteroides fragilis

9293
9901

NZ_JGDE01000091.1

Bacteroides fragilis

22097
21492

NZ_JGDE01000136.1

Bacteroides fragilis

27267
27887

NZ_JH370372.1

Alistipes indistinctus

98423
97824

NZ_JH724294.1

Bacteroides xylanisolvens

2429518
2428898

NZ_PUEL01000004.1

Ruminococcus gnavus

1632318
1631764

NZ_PUEM01000006.1

Clostridium bolteae

5989960
5990487

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2506964
2507572

NZ_PUEP01000005.1

Bacteroides ovatus

917658
918245

NZ_PUEQ01000003.1

Bacteroides caccae

1529639
1529040

NZ_PUEQ01000003.1

Bacteroides caccae

2324622
2325227

NZ_UFTH01000001.1

Bacteroides fragilis

4050588
4051196

NZ_UFTH01000001.1

Bacteroides fragilis

2389564
2388968

NZ_UFTH01000001.1

Bacteroides fragilis

1188676
1189296

NZ_UFTH01000001.1

Bacteroides fragilis

4569605
4569000

NZ_UFTH01000001.1

Bacteroides fragilis

2353159
2352584

NZ_UFTH01000005.1

Bacteroides fragilis

8645
9220

QEKH01000033.1

Victivallis vadensis

30085
29582

NZ_CVOY01000074.1

Bacteroides thetaiotaomicron

35629
37335

NZ_DS544177.1

Anaerotruncus colihominis

189303
188698

NZ_DS995508.1

Bacteroides eggerthii

515682
513877

NZ_DS995532.1

Bacteroides dorei

23809
25614

NZ_EQ973637.1

Bacteroides coprophilus

53028
51301

NZ_EQ973637.1

Bacteroides coprophilus

245618
243906

NZ_EQ973651.1

Bacteroides coprophilus

5698
4001

NZ_UFTH01000001.1

Bacteroides fragilis

4306248
4304464

CVOZ01000037.1

Bacteroides thetaiotaomicron

13492
12218

JGCP01002370.1

Bacteroides fragilis

62642
63922

NC_009614.1

Bacteroides vulgatus

1946317
1945031

NC_009615.1

Parabacteroides distasonis

3695035
3696270

NZ_ABJL02000007.1

Bacteroides intestinalis

1302828
1301614

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

489104
490372

NZ_CVOY01000020.1

Bacteroides thetaiotaomicron

109540
110814

NZ_DS264542.1

Parabacteroides merdae

110435
109170

NZ_DS362243.1

Bacteroides uniformis

74012
72777

NZ_DS499676.1

Bacteroides stercoris

78183
79397

NZ_DS995534.1

Bacteroides dorei

879429
878143

NZ_DS996444.1

Parabacteroides johnsonii

721304
720039

NZ_EQ973492.1

Bacteroides cellulosilyticus

1012038
1013306

NZ_JGDE01000020.1

Bacteroides fragilis

8680
9897

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

20242
18968

NZ_UFTH01000001.1

Bacteroides fragilis

2558717
2559997

BT_2068

1
253

CVOZ01000016.1

Bacteroides thetaiotaomicron

213809
214567

JGCP01001391.1

Bacteroides fragilis

1827
1213

JGCP01002541.1

Bacteroides fragilis

59029
58271

NC_009614.1

Bacteroides vulgatus

2545071
2545832

NZ_AAVM02000007.1

Bacteroides caccae

240333
241091

NZ_ABJL02000002.1

Bacteroides intestinalis

14878
14120

NZ_ATFI01000018.1

Bacteroides cellulosilyticus

73581
72838

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

107627
108385

NZ_DS264546.1

Parabacteroides merdae

161605
162363

NZ_DS264580.1

Bacteroides ovatus

422161
422919

NZ_DS362242.1

Bacteroides uniformis

128891
128124

NZ_DS499676.1

Bacteroides stercoris

354507
353740

NZ_DS995508.1

Bacteroides eggerthii

374349
375116

NZ_DS995536.1

Bacteroides dorei

46897
46136

NZ_DS996453.1

Parabacteroides johnsonii

310455
311213

NZ_EQ973489.1

Bacteroides cellulosilyticus

471401
472159

NZ_EQ973643.1

Bacteroides coprophilus

27626
28387

NZ_GG688318.1

Bacteroides finegoldii

85948
85178

NZ_GG688321.1

Bacteroides finegoldii

185788
185030

NZ_JGDE01000131.1

Bacteroides fragilis

10637
9879

NZ_JH370372.1

Alistipes indistinctus

247945
248700

NZ_JH724296.1

Bacteroides xylanisolvens

113928
113170

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

447878
448636

NZ_PUEP01000015.1

Bacteroides ovatus

275761
276519

NZ_PUEQ01000003.1

Bacteroides caccae

478198
478956

NZ_UFTH01000001.1

Bacteroides fragilis

906258
905500

NZ_DS995536.1

Bacteroides dorei

48870
47308

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

751938
753500

BT_2961

1
285

BT_4075

177
235

BT_4096

158
231

COLAER_00815

96
240

CVOZ01000004.1

Bacteroides thetaiotaomicron

1448
2302

CVOZ01000011.1

Bacteroides thetaiotaomicron

76261
77025

JGCP01002268.1

Bacteroides fragilis

1309
668

NC_009614.1

Bacteroides vulgatus

2618474
2619322

NZ_AAVM02000002.1

Bacteroides caccae

22009
21158

NZ_CVOY01000037.1

Bacteroides thetaiotaomicron

89304
90158

NZ_DS264554.1

Bacteroides ovatus

556078
555293

NZ_DS995537.1

Bacteroides dorei

24054
24902

NZ_DS996456.1

Parabacteroides johnsonii

449203
448439

NZ_JH724295.1

Bacteroides xylanisolvens

331780
330995

NZ_JH724300.1

Bacteroides xylanisolvens

14631
13909

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

699564
698710

NZ_PUEP01000005.1

Bacteroides ovatus

5040250
5041035

NZ_PUEQ01000003.1

Bacteroides caccae

3599902
3600753

CVOZ01000032.1

Bacteroides thetaiotaomicron

278437
277562

CVOZ01000032.1

Bacteroides thetaiotaomicron

327847
326954

CVOZ01000032.1

Bacteroides thetaiotaomicron

335851
336507

CVOZ01000032.1

Bacteroides thetaiotaomicron

289144
289842

CVOZ01000032.1

Bacteroides thetaiotaomicron

289870
290580

CVOZ01000033.1

Bacteroides thetaiotaomicron

38815
37955

JGCP01000713.1

Bacteroides fragilis

233
931

JGCP01000713.1

Bacteroides fragilis

959
1468

JGCP01001256.1

Bacteroides fragilis

1150
194

JGCP01001408.1

Bacteroides fragilis

564
1220

NC_009614.1

Bacteroides vulgatus

2779799
2781439

NC_009614.1

Bacteroides vulgatus

2620046
2620657

NC_009614.1

Bacteroides vulgatus

2619532
2620038

NC_009614.1

Bacteroides vulgatus

2352196
2353167

NC_009614.1

Bacteroides vulgatus

2620668
2621141

NC_009614.1

Bacteroides vulgatus

288953
289606

NC_009614.1

Bacteroides vulgatus

244590
243868

NC_009614.1

Bacteroides vulgatus

245316
244618

NC_009614.1

Bacteroides vulgatus

2620777
2620842

NC_009614.1

Bacteroides vulgatus

2620841
2620945

NZ_AAVM02000003.1

Bacteroides caccae

187381
188355

NZ_AAYG02000020.1

Ruminococcus gnavus

156048
155356

NZ_ABJL02000002.1

Bacteroides intestinalis

153696
152815

NZ_ABJL02000002.1

Bacteroides intestinalis

242190
241192

NZ_ABJL02000008.1

Bacteroides intestinalis

2826397
2825381

NZ_ABJL02000008.1

Bacteroides intestinalis

2603612
2602923

NZ_ABJL02000008.1

Bacteroides intestinalis

3206175
3206885

NZ_ABJL02000008.1

Bacteroides intestinalis

3205449
3206435

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

193354
192338

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

698860
699570

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

698128
699120

NZ_ATFI01000006.1

Bacteroides cellulosilyticus

337473
338303

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

425892
425203

NZ_CVOY01000002.1

Bacteroides thetaiotaomicron

10928
11803

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

33471
34445

NZ_CVOY01000030.1

Bacteroides thetaiotaomicron

60870
61763

NZ_CVOY01000030.1

Bacteroides thetaiotaomicron

51365
50709

NZ_CVOY01000108.1

Bacteroides thetaiotaomicron

179
877

NZ_CVOY01000108.1

Bacteroides thetaiotaomicron

905
1615

NZ_DS264554.1

Bacteroides ovatus

198660
199562

NZ_DS264554.1

Bacteroides ovatus

197946
198665

NZ_DS264579.1

Bacteroides ovatus

101730
101050

NZ_DS264579.1

Bacteroides ovatus

102462
101758

NZ_DS264584.1

Bacteroides ovatus

301586
302560

NZ_DS264584.1

Bacteroides ovatus

428271
429146

NZ_DS264584.1

Bacteroides ovatus

377614
376958

NZ_DS264584.1

Bacteroides ovatus

434485
435183

NZ_DS264584.1

Bacteroides ovatus

417597
416878

NZ_DS264584.1

Bacteroides ovatus

418350
417574

NZ_DS362249.1

Bacteroides uniformis

289634
288054

NZ_DS499676.1

Bacteroides stercoris

561250
560255

NZ_DS981517.1

Clostridium sporogenes

457008
457370

NZ_DS990171.1

Ruminococcus lactaris

5187
5534

NZ_DS995509.1

Bacteroides eggerthii

327513
328508

NZ_DS995531.1

Bacteroides dorei

93535
94410

NZ_DS995531.1

Bacteroides dorei

50130
49477

NZ_DS995531.1

Bacteroides dorei

106361
107083

NZ_DS995531.1

Bacteroides dorei

105635
106333

NZ_DS995536.1

Bacteroides dorei

242505
241396

NZ_DS995537.1

Bacteroides dorei

25114
27072

NZ_DS995537.1

Bacteroides dorei

1373127
1374776

NZ_DS996921.1

Bacteroides pectinophilus

1405526
1406158

NZ_EQ973486.1

Bacteroides cellulosilyticus

92459
91749

NZ_EQ973486.1

Bacteroides cellulosilyticus

93191
92199

NZ_EQ973489.1

Bacteroides cellulosilyticus

322372
323022

NZ_EQ973491.1

Bacteroides cellulosilyticus

393142
394158

NZ_EQ973491.1

Bacteroides cellulosilyticus

671842
672531

NZ_EQ973492.1

Bacteroides cellulosilyticus

492581
491853

NZ_GG688320.1

Bacteroides finegoldii

264894
263914

NZ_GG688320.1

Bacteroides finegoldii

202708
203607

NZ_GG688320.1

Bacteroides finegoldii

231551
232207

NZ_GG688320.1

Bacteroides finegoldii

195186
194512

NZ_GG688320.1

Bacteroides finegoldii

209971
210669

NZ_GG688320.1

Bacteroides finegoldii

210700
211410

NZ_GG692716.1

Roseburia intestinalis

57615
58253

NZ_GG703858.1

Prevotella copri

109675
108758

NZ_JH370372.1

Alistipes indistinctus

102822
102526

NZ_JH724294.1

Bacteroides xylanisolvens

390497
391471

NZ_PUEL01000004.1

Ruminococcus gnavus

1641783
1641091

NZ_PUEL01000004.1

Ruminococcus gnavus

2394471
2394827

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

899572
900546

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1031435
1032310

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

982003
982896

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

973993
973337

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1020728
1020030

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1020002
1019292

NZ_PUEP01000005.1

Bacteroides ovatus

3144163
3143189

NZ_PUEP01000005.1

Bacteroides ovatus

5398858
5397956

NZ_PUEP01000005.1

Bacteroides ovatus

3017478
3016603

NZ_PUEP01000005.1

Bacteroides ovatus

5399572
5398853

NZ_PUEP01000005.1

Bacteroides ovatus

3068135
3068791

NZ_PUEP01000005.1

Bacteroides ovatus

3011264
3010566

NZ_PUEP01000005.1

Bacteroides ovatus

3028152
3028871

NZ_PUEP01000005.1

Bacteroides ovatus

3027399
3028175

NZ_PUEP01000005.1

Bacteroides ovatus

4920170
4920850

NZ_PUEP01000005.1

Bacteroides ovatus

4919438
4920142

NZ_PUEQ01000003.1

Bacteroides caccae

2517594
2516620

QEKH01000014.1

Victivallis vadensis

69266
69907

BT_1192

363
462

BT_3124

260
347

COLAER_00815

69
229

CVOZ01000032.1

Bacteroides thetaiotaomicron

320584
319970

CVOZ01000032.1

Bacteroides thetaiotaomicron

279286
278453

NC_009614.1

Bacteroides vulgatus

3010156
3011628

NZ_ABJL02000002.1

Bacteroides intestinalis

241062
240220

NZ_ABJL02000008.1

Bacteroides intestinalis

2609905
2610504

NZ_CVOY01000002.1

Bacteroides thetaiotaomicron

10079
10912

NZ_CVOY01000030.1

Bacteroides thetaiotaomicron

76891
77505

NZ_DS264584.1

Bacteroides ovatus

442833
441991

NZ_DS995537.1

Bacteroides dorei

355341
356813

NZ_DS996921.1

Bacteroides pectinophilus

215285
215857

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

989267
989881

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1030586
1031419

NZ_PUEP01000005.1

Bacteroides ovatus

3002916
3003758

CVOZ01000025.1

Bacteroides thetaiotaomicron

228497
228021

JGCP01002418.1

Bacteroides fragilis

53739
53263

NC_009614.1

Bacteroides vulgatus

3013253
3012750

NC_009615.1

Parabacteroides distasonis

2483154
2482669

NC_012781.1

Eubacterium rectale

275468
275845

NZ_AAVM02000006.1

Bacteroides caccae

294260
293784

NZ_AAXA02000015.1

Dorea formicigenerans

81674
81237

NZ_AAYG02000020.1

Ruminococcus gnavus

14089
13706

NZ_ABJL02000008.1

Bacteroides intestinalis

1575489
1575968

NZ_ABXA01000014.1

Anaerococcus hydrogenalis

10995
11324

NZ_ACCL02000004.1

Marvinbryantia formatexigens

228462
228866

NZ_ATFI01000017.1

Bacteroides cellulosilyticus

48893
49372

NZ_CVOY01000013.1

Bacteroides thetaiotaomicron

68589
68113

NZ_DS264284.1

Eubacterium ventriosum

34205
33930

NZ_DS264346.1

Ruminococcus torques

54583
54975

NZ_DS264518.1

Parabacteroides merdae

43023
43499

NZ_DS264583.1

Bacteroides ovatus

165036
165512

NZ_DS362249.1

Bacteroides uniformis

38171
38653

NZ_DS480678.1

Clostridium bolteae

117255
116866

NZ_DS499655.1

Erysipelatoclostridium ramosum

390371
390754

NZ_DS499671.1

Bacteroides stercoris

73424
73900

NZ_DS499697.1

Clostridium scindens

310825
310430

NZ_DS544181.1

Anaerotruncus colihominis

168009
167620

NZ_DS562853.1

Clostridium spiroforme

159590
159871

NZ_DS981517.1

Clostridium sporogenes

734347
734709

NZ_DS990204.1

Ruminococcus lactaris

1040
633

NZ_DS995509.1

Bacteroides eggerthii

1263753
1263277

NZ_DS995537.1

Bacteroides dorei

357809
357306

NZ_DS996456.1

Parabacteroides johnsonii

29766
29311

NZ_DS996922.1

Bacteroides pectinophilus

5548
5931

NZ_EQ973488.1

Bacteroides cellulosilyticus

349840
350319

NZ_EQ973651.1

Bacteroides coprophilus

150422
149964

NZ_GG657592.1

Clostridium asparagiforme

1177311
1177730

NZ_GG667608.1

Hungatella hathewayi

147420
147797

NZ_GG688318.1

Bacteroides finegoldii

355312
354836

NZ_GG692711.1

Collinsella intestinalis

96648
97034

NZ_GG692730.1

Roseburia intestinalis

30330
29962

NZ_GG698588.1

Blautia hansenii

167573
167190

NZ_GG703872.1

Prevotella copri

670
194

NZ_GG704769.1

Subdoligranulum variabile

1484289
1483900

NZ_JGDE01000051.1

Bacteroides fragilis

16766
16290

NZ_JH370372.1

Alistipes indistinctus

1077514
1077068

NZ_JH724297.1

Bacteroides xylanisolvens

316915
317391

NZ_KE136402.1

Enterococcus faecalis

75167
74802

NZ_MTWC01000003.1

Clostridioides difficile

2570171
2569785

NZ_MTWD01000001.1

Clostridioides difficile

2608785
2608399

NZ_MTWE01000004.1

Clostridioides difficile

2328222
2327836

NZ_PUEL01000004.1

Ruminococcus gnavus

1499825
1499442

NZ_PUEM01000006.1

Clostridium bolteae

4150728
4151117

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3701254
3701730

NZ_PUEP01000005.1

Bacteroides ovatus

339730
339254

NZ_PUEQ01000002.1

Bacteroides caccae

341319
340843

NZ_UFTH01000001.1

Bacteroides fragilis

3641424
3640948

CVOZ01000042.1

Bacteroides thetaiotaomicron

34688
34368

JGCP01002359.1

Bacteroides fragilis

41007
41324

NC_000913.3

Escherichia coli

904593
904904

NC_009614.1

Bacteroides vulgatus

3013445
3013765

NC_009615.1

Parabacteroides distasonis

3249031
3249348

NZ_AAVM02000009.1

Bacteroides caccae

17283
17603

NZ_ABJL02000007.1

Bacteroides intestinalis

704388
704705

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

421004
420687

NZ_CVOY01000010.1

Bacteroides thetaiotaomicron

7919
7599

NZ_DS264359.1

Ruminococcus torques

17253
17570

NZ_DS264364.1

Ruminococcus torques

42135
42452

NZ_DS264544.1

Parabacteroides merdae

742
425

NZ_DS362223.1

Bacteroides uniformis

11655
11972

NZ_DS362246.1

Bacteroides uniformis

3066
3389

NZ_DS499674.1

Bacteroides stercoris

462363
462680

NZ_DS544185.1

Anaerotruncus colihominis

14445
14128

NZ_DS562844.1

Clostridium spiroforme

291249
291566

NZ_DS981517.1

Clostridium sporogenes

935496
935179

NZ_DS990238.1

Bifidobacterium longum

668976
668662

NZ_DS995511.1

Bacteroides eggerthii

638934
639251

NZ_DS995537.1

Bacteroides dorei

358000
358320

NZ_DS996456.1

Parabacteroides johnsonii

1015093
1015410

NZ_EQ973490.1

Bacteroides cellulosilyticus

533321
533004

NZ_EQ973647.1

Bacteroides coprophilus

14447
14764

NZ_GG692710.1

Collinsella intestinalis

1023607
1023903

NZ_GG703853.1

Prevotella copri

386355
386041

NZ_GG704863.1

Enterobacter cancerogenus

413348
413659

NZ_GG729830.1

Bifidobacterium breve

191349
191663

NZ_JGDE01000013.1

Bacteroides fragilis

22693
23010

NZ_JH724295.1

Bacteroides xylanisolvens

1124087
1124407

NZ_MTWC01000003.1

Clostridioides difficile

1788196
1788510

NZ_MTWD01000001.1

Clostridioides difficile

1830939
1831253

NZ_MTWE01000004.1

Clostridioides difficile

1523761
1524075

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

1360437
1360757

NZ_PUEQ01000003.1

Bacteroides caccae

3090859
3090539

NZ_UFTH01000001.1

Bacteroides fragilis

2193266
2193583

BACDOR_03648

2
191

CVOZ01000037.1

Bacteroides thetaiotaomicron

90333
89671

CVOZ01000037.1

Bacteroides thetaiotaomicron

90656
90387

JGCP01002370.1

Bacteroides fragilis

19946
20590

JGCP01002370.1

Bacteroides fragilis

19647
19904

NC_009614.1

Bacteroides vulgatus

3014449
3013841

NC_009614.1

Bacteroides vulgatus

3015154
3014498

NZ_AAVM02000001.1

Bacteroides caccae

401183
401740

NZ_AAVM02000001.1

Bacteroides caccae

400813
401082

NZ_ABJL02000008.1

Bacteroides intestinalis

189847
189212

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

182016
182639

NZ_CVOY01000020.1

Bacteroides thetaiotaomicron

75232
75894

NZ_CVOY01000020.1

Bacteroides thetaiotaomicron

74909
75178

NZ_DS264554.1

Bacteroides ovatus

96010
95354

NZ_DS264554.1

Bacteroides ovatus

96327
96058

NZ_DS362237.1

Bacteroides uniformis

68919
68383

NZ_DS995537.1

Bacteroides dorei

359004
358396

NZ_DS995537.1

Bacteroides dorei

359709
359053

NZ_EQ973492.1

Bacteroides cellulosilyticus

702548
703171

NZ_GG703853.1

Prevotella copri

10442
9792

NZ_JGDE01000019.1

Bacteroides fragilis

85207
85851

NZ_JGDE01000019.1

Bacteroides fragilis

84908
85165

NZ_JH724299.1

Bacteroides xylanisolvens

71964
72233

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

97086
96424

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

97409
97140

NZ_PUEP01000005.1

Bacteroides ovatus

5502584
5503240

NZ_PUEP01000005.1

Bacteroides ovatus

5502267
5502536

NZ_PUEQ01000003.1

Bacteroides caccae

74218
74775

NZ_PUEQ01000003.1

Bacteroides caccae

73848
74117

NZ_UFTH01000001.1

Bacteroides fragilis

2516016
2516660

NZ_UFTH01000001.1

Bacteroides fragilis

2515717
2515974

BACDOR_03647

31
202

CVOZ01000037.1

Bacteroides thetaiotaomicron

90246
89671

JGCP01002370.1

Bacteroides fragilis

20039
20590

NC_009614.1

Bacteroides vulgatus

3015070
3014486

NC_009614.1

Bacteroides vulgatus

3014359
3013844

NZ_AAVM02000001.1

Bacteroides caccae

401216
401779

NZ_AAVM02000001.1

Bacteroides caccae

400750
401082

NZ_ABJL02000008.1

Bacteroides intestinalis

189775
189191

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

182088
182639

NZ_CVOY01000020.1

Bacteroides thetaiotaomicron

75319
75894

NZ_DS264554.1

Bacteroides ovatus

95923
95354

NZ_DS264554.1

Bacteroides ovatus

96381
96097

NZ_DS362237.1

Bacteroides uniformis

68919
68383

NZ_DS995537.1

Bacteroides dorei

359625
359041

NZ_DS995537.1

Bacteroides dorei

358914
358399

NZ_EQ973492.1

Bacteroides cellulosilyticus

702620
703171

NZ_GG688330.1

Bacteroides finegoldii

122724
123047

NZ_GG703853.1

Prevotella copri

10352
9831

NZ_JGDE01000019.1

Bacteroides fragilis

85300
85851

NZ_JH724299.1

Bacteroides xylanisolvens

71928
72194

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

96999
96424

NZ_PUEP01000005.1

Bacteroides ovatus

5502671
5503240

NZ_PUEP01000005.1

Bacteroides ovatus

5502213
5502497

NZ_PUEQ01000003.1

Bacteroides caccae

74251
74814

NZ_PUEQ01000003.1

Bacteroides caccae

73785
74117

NZ_UFTH01000001.1

Bacteroides fragilis

2516109
2516660

BT_2367

1
382

CVOZ01000011.1

Bacteroides thetaiotaomicron

219307
218162

CVOZ01000025.1

Bacteroides thetaiotaomicron

65956
64922

JGCP01000352.1

Bacteroides fragilis

1001
3

JGCP01002360.1

Bacteroides fragilis

22362
21214

NC_009614.1

Bacteroides vulgatus

3184401
3185549

NC_009615.1

Parabacteroides distasonis

4010282
4011415

NC_010655.1

Akkermansia muciniphila

2181545
2180451

NC_010655.1

Akkermansia muciniphila

910779
911906

NZ_AAVM02000006.1

Bacteroides caccae

286961
285936

NZ_AAVM02000010.1

Bacteroides caccae

85750
86895

NZ_ABJL02000007.1

Bacteroides intestinalis

1352596
1353708

NZ_ABJL02000008.1

Bacteroides intestinalis

11440
12579

NZ_ACEP01000056.1

Eubacterium hallii

19442
19756

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

320605
319457

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

180818
179655

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

433197
432085

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

454543
453536

NZ_CVOY01000001.1

Bacteroides thetaiotaomicron

78559
77414

NZ_CVOY01000013.1

Bacteroides thetaiotaomicron

61418
60384

NZ_DS264546.1

Parabacteroides merdae

79517
80632

NZ_DS264553.1

Bacteroides ovatus

176886
178034

NZ_DS264583.1

Bacteroides ovatus

172699
173733

NZ_DS362220.1

Bacteroides uniformis

32930
34078

NZ_DS362243.1

Bacteroides uniformis

130985
132106

NZ_DS499676.1

Bacteroides stercoris

625044
623935

NZ_DS499676.1

Bacteroides stercoris

38390
37269

NZ_DS995510.1

Bacteroides eggerthii

1115618
1114497

NZ_DS995537.1

Bacteroides dorei

622799
623947

NZ_DS996453.1

Parabacteroides johnsonii

228018
229163

NZ_DS996453.1

Parabacteroides johnsonii

441885
442970

NZ_EQ973492.1

Bacteroides cellulosilyticus

841963
840815

NZ_EQ973492.1

Bacteroides cellulosilyticus

701350
700187

NZ_EQ973495.1

Bacteroides cellulosilyticus

221652
222659

NZ_EQ973543.1

Bacteroides cellulosilyticus

701
3

NZ_EQ973643.1

Bacteroides coprophilus

523657
524796

NZ_GG688326.1

Bacteroides finegoldii

160819
161967

NZ_JH370372.1

Alistipes indistinctus

793551
792436

NZ_JH724294.1

Bacteroides xylanisolvens

2266288
2265140

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

85095
83950

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3708426
3709460

NZ_PUEP01000005.1

Bacteroides ovatus

1142186
1143334

NZ_PUEP01000005.1

Bacteroides ovatus

332067
331033

NZ_PUEQ01000002.1

Bacteroides caccae

334020
332995

NZ_PUEQ01000003.1

Bacteroides caccae

2119148
2118003

NZ_UFTH01000001.1

Bacteroides fragilis

2311470
2310322

BT_0152

21
272

COLAER_01894

110
150

CVOZ01000033.1

Bacteroides thetaiotaomicron

95414
94584

CVOZ01000058.1

Bacteroides thetaiotaomicron

56650
57405

JGCP01002414.1

Bacteroides fragilis

51703
52458

NC_000913.3

Escherichia coli

3900190
3899414

NC_009614.1

Bacteroides vulgatus

3187980
3188795

NC_009615.1

Parabacteroides distasonis

3801163
3801933

NC_009615.1

Parabacteroides distasonis

2376805
2377557

NZ_AAVM02000004.1

Bacteroides caccae

216505
217236

NZ_ABJL02000007.1

Bacteroides intestinalis

250198
250920

NZ_ABJL02000008.1

Bacteroides intestinalis

1128333
1127566

NZ_ABJL02000008.1

Bacteroides intestinalis

2507036
2506242

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

437624
437184

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

397686
398429

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

325780
324986

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

23231
22401

NZ_CVOY01000040.1

Bacteroides thetaiotaomicron

78733
78002

NZ_DS264541.1

Parabacteroides merdae

313243
313983

NZ_DS264541.1

Parabacteroides merdae

27216
26359

NZ_DS264554.1

Bacteroides ovatus

368631
369470

NZ_DS264554.1

Bacteroides ovatus

367127
367921

NZ_DS362233.1

Bacteroides uniformis

74461
73730

NZ_DS362239.1

Bacteroides uniformis

7728
6928

NZ_DS362239.1

Bacteroides uniformis

5156
4731

NZ_DS362240.1

Bacteroides uniformis

212934
213686

NZ_DS499653.1

Erysipelatoclostridium ramosum

194977
194246

NZ_DS499673.1

Bacteroides stercoris

206561
207376

NZ_DS607663.1

Providencia stuartii

1086310
1087089

NZ_DS995510.1

Bacteroides eggerthii

209097
209912

NZ_DS995537.1

Bacteroides dorei

626379
627194

NZ_DS995537.1

Bacteroides dorei

1307678
1306917

NZ_DS996440.1

Parabacteroides johnsonii

32520
31849

NZ_DS996532.1

Parabacteroides johnsonii

838
98

NZ_DS996921.1

Bacteroides pectinophilus

1565854
1566558

NZ_EQ973490.1

Bacteroides cellulosilyticus

1229269
1228547

NZ_EO973490.1

Bacteroides cellulosilyticus

549879
549439

NZ_EQ973491.1

Bacteroides cellulosilyticus

776889
777764

NZ_EQ973495.1

Bacteroides cellulosilyticus

279325
278582

NZ_EQ973651.1

Bacteroides coprophilus

37033
36287

NZ_GG667608.1

Hungatella hathewayi

95800
95153

NZ_GG667608.1

Hungatella hathewayi

94944
94324

NZ_GG688325.1

Bacteroides finegoldii

120247
120978

NZ_GG704769.1

Subdoligranulum variabile

177713
178351

NZ_GG705264.1

Providencia rettgeri

106827
106045

NZ_JGDE01000048.1

Bacteroides fragilis

11590
12345

NZ_JH370371.1

Alistipes indistinctus

55343
54528

NZ_JH370371.1

Alistipes indistinctus

53836
52994

NZ_JH724294.1

Bacteroides xylanisolvens

1276334
1277065

NZ_KB946519.1

Enterococcus faecalis

364107
364835

NZ_MTWC01000003.1

Clostridioides difficile

2304297
2303677

NZ_MTWD01000001.1

Clostridioides difficile

2346475
2345855

NZ_MTWE01000004.1

Clostridioides difficile

2075454
2074834

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1959081
1959812

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

843093
843923

NZ_PUEP01000005.1

Bacteroides ovatus

2224557
2223826

NZ_PUEP01000005.1

Bacteroides ovatus

5227698
5226859

NZ_PUEP01000005.1

Bacteroides ovatus

5229202
5228408

NZ_PUEQ01000003.1

Bacteroides caccae

1833970
1833239

NZ_UFTH01000001.1

Bacteroides fragilis

3547965
3548720

NZ_UFTH01000001.1

Bacteroides fragilis

1289092
1288223

QEKH01000010.1

Victivallis vadensis

10295
9546

BACDOR_00571

1
175

BT_0217

24
198

BT_1006

10
78

BT_1148

4
168

COLAER_01707

4
116

CVOZ01000022.1

Bacteroides thetaiotaomicron

96972
97520

CVOZ01000044.1

Bacteroides thetaiotaomicron

270175
270669

CVOZ01000058.1

Bacteroides thetaiotaomicron

90345
90884

CVOZ01000063.1

Bacteroides thetaiotaomicron

213261
213785

JGCP01001429.1

Bacteroides fragilis

413
3

JGCP01002513.1

Bacteroides fragilis

8425
7883

JGCP01002532.1

Bacteroides fragilis

1963
1505

NC_000913.3

Escherichia coli

891154
891663

NC_009614.1

Bacteroides vulgatus

3238698
3238072

NC_009614.1

Bacteroides vulgatus

2553354
2553818

NC_009614.1

Bacteroides vulgatus

3195978
3196472

NC_009614.1

Bacteroides vulgatus

1289396
1288881

NC_009615.1

Parabacteroides distasonis

2044441
2044980

NC_009615.1

Parabacteroides distasonis

185216
184800

NC_009615.1

Parabacteroides distasonis

178476
179009

NZ_AAVM02000001.1

Bacteroides caccae

1119730
1119206

NZ_AAVM02000004.1

Bacteroides caccae

244889
245428

NZ_AAVM02000005.1

Bacteroides caccae

238680
239204

NZ_AAVM02000006.1

Bacteroides caccae

117389
117928

NZ_AAXA02000015.1

Dorea formicigenerans

812473
812982

NZ_AAXA02000015.1

Dorea formicigenerans

428131
428625

NZ_ABJL02000007.1

Bacteroides intestinalis

959684
959124

NZ_ABJL02000008.1

Bacteroides intestinalis

2984882
2985400

NZ_ABJL02000008.1

Bacteroides intestinalis

1297560
1297051

NZ_ABJL02000008.1

Bacteroides intestinalis

1656565
1656050

NZ_ACCL02000001.1

Marvinbryantia formatexigens

116305
116820

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1579965
1579402

NZ_ATFI01000002.1

Bacteroides cellulosilyticus

1183
659

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

389835
390377

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

572189
572641

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

229474
229983

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

48939
48499

NZ_CVOY01000018.1

Bacteroides thetaiotaomicron

29429
29977

NZ_CVOY01000040.1

Bacteroides thetaiotaomicron

40363
39824

NZ_CVOY01000042.1

Bacteroides thetaiotaomicron

62949
62425

NZ_CVOY01000048.1

Bacteroides thetaiotaomicron

31365
31859

NZ_DS264519.1

Parabacteroides merdae

6745
7230

NZ_DS264542.1

Parabacteroides merdae

249165
248725

NZ_DS264546.1

Parabacteroides merdae

3190
2678

NZ_DS264582.1

Bacteroides ovatus

368678
369202

NZ_DS264583.1

Bacteroides ovatus

339955
339416

NZ_DS362240.1

Bacteroides uniformis

130419
130928

NZ_DS362244.1

Bacteroides uniformis

170466
170960

NZ_DS362248.1

Bacteroides uniformis

308142
308660

NZ_DS480690.1

Clostridium bolteae

89583
90038

NZ_DS480690.1

Clostridium bolteae

244847
244362

NZ_DS480692.1

Clostridium bolteae

142221
141733

NZ_DS499655.1

Erysipelatoclostridium ramosum

354515
355036

NZ_DS499657.1

Erysipelatoclostridium ramosum

40323
39829

NZ_DS499672.1

Bacteroides stercoris

113142
113645

NZ_DS499673.1

Bacteroides stercoris

148946
149485

NZ_DS499674.1

Bacteroides stercoris

145503
146033

NZ_DS499697.1

Clostridium scindens

325349
325756

NZ_DS499701.1

Clostridium scindens

43469
43026

NZ_DS562853.1

Clostridium spiroforme

140554
141075

NZ_DS981517.1

Clostridium sporogenes

1671572
1672060

NZ_DS981517.1

Clostridium sporogenes

2367337
2367867

NZ_DS981517.1

Clostridium sporogenes

557173
557640

NZ_DS981518.1

Clostridium sporogenes

1128355
1127867

NZ_DS981518.1

Clostridium sporogenes

1189238
1189765

NZ_DS981518.1

Clostridium sporogenes

524044
524577

NZ_DS995509.1

Bacteroides eggerthii

1232496
1232957

NZ_DS995510.1

Bacteroides eggerthii

106112
106669

NZ_DS995510.1

Bacteroides eggerthii

730874
731398

NZ_DS995534.1

Bacteroides dorei

71649
71125

NZ_DS995536.1

Bacteroides dorei

38613
38149

NZ_DS995537.1

Bacteroides dorei

674934
674308

NZ_DS995537.1

Bacteroides dorei

634373
634867

NZ_DS996441.1

Parabacteroides johnsonii

40022
40534

NZ_DS996445.1

Parabacteroides johnsonii

6103
6588

NZ_DS996446.1

Parabacteroides johnsonii

59146
59586

NZ_DS996844.1

Holdemanella biformis

9192
9704

NZ_DS996847.1

Holdemanella biformis

35958
36458

NZ_EQ973488.1

Bacteroides cellulosilyticus

47287
46763

NZ_EQ973490.1

Bacteroides cellulosilyticus

1771328
1770765

NZ_EQ973491.1

Bacteroides cellulosilyticus

190402
189860

NZ_EQ973492.1

Bacteroides cellulosilyticus

269760
270200

NZ_EQ973495.1

Bacteroides cellulosilyticus

467156
466647

NZ_EQ973650.1

Bacteroides coprophilus

309687
310124

NZ_EQ973651.1

Bacteroides coprophilus

186888
186394

NZ_GG657592.1

Clostridium asparagiforme

256642
256139

NZ_GG657595.1

Clostridium asparagiforme

13750
13259

NZ_GG662014.1

Coprococcus comes

272777
273259

NZ_GG667651.1

Hungatella hathewayi

1953
2384

NZ_GG688331.1

Bacteroides finegoldii

31959
32501

NZ_GG688334.1

Bacteroides finegoldii

50722
51141

NZ_GG688343.1

Bacteroides finegoldii

10025
9501

NZ_GG692723.1

Roseburia intestinalis

45117
44662

NZ_GG698588.1

Blautia hansenii

717359
717898

NZ_GG698590.1

Blautia hansenii

424894
424328

NZ_GG698591.1

Blautia hansenii

291854
291342

NZ_GG703857.1

Prevotella copri

74622
74996

NZ_JGDE01000109.1

Bacteroides fragilis

17572
17084

NZ_JGDE01000119.1

Bacteroides fragilis

36868
36326

NZ_JGDE01000120.1

Bacteroides fragilis

100596
100087

NZ_JGDE01000126.1

Bacteroides fragilis

19672
19214

NZ_JH370371.1

Alistipes indistinctus

1207476
1206925

NZ_JH724294.1

Bacteroides xylanisolvens

1305623
1306168

NZ_JH724294.1

Bacteroides xylanisolvens

1743280
1743804

NZ_JH724297.1

Bacteroides xylanisolvens

31681
31157

NZ_JH724298.1

Bacteroides xylanisolvens

164880
165410

NZ_KE993038.1

Clostridium symbiosum

28562
29077

NZ_MTWC01000003.1

Clostridioides difficile

183069
182578

NZ_MTWC01000003.1

Clostridioides difficile

3694880
3694437

NZ_MTWC01000003.1

Clostridioides difficile

851750
852229

NZ_MTWC01000003.1

Clostridioides difficile

764218
764397

NZ_MTWD01000001.1

Clostridioides difficile

272104
271613

NZ_MTWD01000001.1

Clostridioides difficile

3699847
3699404

NZ_MTWD01000001.1

Clostridioides difficile

951766
952245

NZ_MTWD01000001.1

Clostridioides difficile

864276
864455

NZ_MTWE01000004.1

Clostridioides difficile

644539
645069

NZ_MTWE01000004.1

Clostridioides difficile

3362776
3362321

NZ_MTWE01000004.1

Clostridioides difficile

562108
562287

NZ_MTWF01000010.1

Clostridioides difficile

538767
539246

NZ_MTWF01000010.1

Clostridioides difficile

451166
451345

NZ_MTWF01000021.1

Clostridioides difficile

734552
734109

NZ_PUEM01000006.1

Clostridium bolteae

4759215
4759670

NZ_PUEM01000006.1

Clostridium bolteae

4326854
4327342

NZ_PUEM01000006.1

Clostridium bolteae

4914475
4913990

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1992590
1993129

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3444721
3444197

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3875031
3874483

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3235794
3235300

NZ_PUEP01000005.1

Bacteroides ovatus

2195846
2195307

NZ_PUEP01000005.1

Bacteroides ovatus

164812
165351

NZ_PUEP01000005.1

Bacteroides ovatus

1680431
1679907

NZ_PUEP01000005.1

Bacteroides ovatus

683462
683986

NZ_PUEQ01000002.1

Bacteroides caccae

164447
164986

NZ_PUEQ01000002.1

Bacteroides caccae

605566
606090

NZ_PUEQ01000003.1

Bacteroides caccae

1805586
1805047

NZ_PUEQ01000003.1

Bacteroides caccae

1408541
1408017

NZ_UFTH01000001.1

Bacteroides fragilis

276153
275611

NZ_UFTH01000001.1

Bacteroides fragilis

384961
384452

NZ_UFTH01000001.1

Bacteroides fragilis

627416
626958

NZ_UFTH01000002.1

Bacteroides fragilis

31630
32118

QEKH01000020.1

Victivallis vadensis

34973
35503

BACDOR_03937

21
270

CVOZ01000033.1

Bacteroides thetaiotaomicron

95366
94584

CVOZ01000058.1

Bacteroides thetaiotaomicron

56629
57405

CVOZ01000324.1

Bacteroides thetaiotaomicron

70
687

JGCP01002414.1

Bacteroides fragilis

51709
52458

NC_000913.3

Escherichia coli

3900130
3899411

NC_009614.1

Bacteroides vulgatus

3188040
3188789

NC_009615.1

Parabacteroides distasonis

3801181
3801927

NC_009615.1

Parabacteroides distasonis

2376805
2377560

NC_009615.1

Parabacteroides distasonis

3194728
3195453

NZ_AAVM02000004.1

Bacteroides caccae

216499
217236

NZ_ABJL02000001.1

Bacteroides intestinalis

92931
93386

NZ_ABJL02000007.1

Bacteroides intestinalis

250216
250953

NZ_ABJL02000007.1

Bacteroides intestinalis

251344
252009

NZ_ABJL02000007.1

Bacteroides intestinalis

167594
168043

NZ_ABJL02000008.1

Bacteroides intestinalis

1128321
1127566

NZ_ABJL02000008.1

Bacteroides intestinalis

2507054
2506242

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

437645
436902

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1152160
1151711

NZ_ATFI01000006.1

Bacteroides cellulosilyticus

51099
51554

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

397689
398429

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

325798
324986

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

23183
22401

NZ_CVOY01000040.1

Bacteroides thetaiotaomicron

78754
77978

NZ_DS264269.1

Eubacterium ventriosum

37509
38012

NZ_DS264541.1

Parabacteroides merdae

313249
313983

NZ_DS264541.1

Parabacteroides merdae

27165
26368

NZ_DS264554.1

Bacteroides ovatus

368625
369458

NZ_DS264554.1

Bacteroides ovatus

367145
367924

NZ_DS362233.1

Bacteroides uniformis

74458
73727

NZ_DS362239.1

Bacteroides uniformis

7728
6928

NZ_DS362239.1

Bacteroides uniformis

5192
4449

NZ_DS362239.1

Bacteroides uniformis

6443
5691

NZ_DS362240.1

Bacteroides uniformis

212961
213686

NZ_DS499653.1

Erysipelatoclostridium ramosum

194977
194246

NZ_DS499673.1

Bacteroides stercoris

206600
207376

NZ_DS607663.1

Providencia stuartii

1086289
1086999

NZ_DS995510.1

Bacteroides eggerthii

209136
209912

NZ_DS995510.1

Bacteroides eggerthii

640756
640298

NZ_DS995511.1

Bacteroides eggerthii

708500
707925

NZ_DS995511.1

Bacteroides eggerthii

707389
706949

NZ_DS995537.1

Bacteroides dorei

626439
627188

NZ_DS995537.1

Bacteroides dorei

1307660
1306917

NZ_DS996440.1

Parabacteroides johnsonii

32532
31852

NZ_DS996532.1

Parabacteroides johnsonii

832
98

NZ_DS996921.1

Bacteroides pectinophilus

1565959
1566558

NZ_EQ973489.1

Bacteroides cellulosilyticus

600373
600828

NZ_EQ973490.1

Bacteroides cellulosilyticus

549900
549157

NZ_EQ973490.1

Bacteroides cellulosilyticus

1229254
1228514

NZ_EQ973490.1

Bacteroides cellulosilyticus

1339191
1338574

NZ_EQ973490.1

Bacteroides cellulosilyticus

1228123
1227458

NZ_EQ973490.1

Bacteroides cellulosilyticus

1340362
1339898

NZ_EQ973490.1

Bacteroides cellulosilyticus

1351952
1351503

NZ_EQ973491.1

Bacteroides cellulosilyticus

776952
777764

NZ_EQ973495.1

Bacteroides cellulosilyticus

279328
278582

NZ_EQ973651.1

Bacteroides coprophilus

37045
36284

NZ_GG667608.1

Hungatella hathewayi

95881
95153

NZ_GG667608.1

Hungatella hathewayi

95064
94324

NZ_GG667610.1

Hungatella hathewayi

17497
18186

NZ_GG688325.1

Bacteroides finegoldii

120232
120978

NZ_GG692718.1

Roseburia intestinalis

47376
46933

NZ_GG704769.1

Subdoligranulum variabile

177725
178351

NZ_GG705264.1

Providencia rettgeri

106848
106150

NZ_JGDE01000048.1

Bacteroides fragilis

11596
12345

NZ_JH370371.1

Alistipes indistinctus

55352
54528

NZ_JH370371.1

Alistipes indistinctus

53842
52994

NZ_JH724294.1

Bacteroides xylanisolvens

1276319
1277065

NZ_KB946519.1

Enterococcus faecalis

364107
364844

NZ_MTWC01000003.1

Clostridioides difficile

2304288
2303677

NZ_MTWD01000001.1

Clostridioides difficile

2346466
2345855

NZ_MTWE01000004.1

Clostridioides difficile

2075445
2074834

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1959060
1959836

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

843141
843923

NZ_PUEP01000005.1

Bacteroides ovatus

2224578
2223826

NZ_PUEP01000005.1

Bacteroides ovatus

5227704
5226871

NZ_PUEP01000005.1

Bacteroides ovatus

5229184
5228405

NZ_PUEQ01000003.1

Bacteroides caccae

1833976
1833239

NZ_UFTH01000001.1

Bacteroides fragilis

3547971
3548720

QEKH01000010.1

Victivallis vadensis

10220
9546

BACDOR_03988

38
188

CVOZ01000058.1

Bacteroides thetaiotaomicron

139616
140215

JGCP01002512.1

Bacteroides fragilis

11361
10762

NC_009615.1

Parabacteroides distasonis

4480120
4479551

NC_010655.1

Akkermansia muciniphila

306289
306831

NC_010655.1

Akkermansia muciniphila

905733
906320

NZ_AAVM02000004.1

Bacteroides caccae

286126
286725

NZ_ABJL02000008.1

Bacteroides intestinalis

1732043
1731456

NZ_ATFI01000002.1

Bacteroides cellulosilyticus

82757
82170

NZ_CVOY01000066.1

Bacteroides thetaiotaomicron

9741
10340

NZ_DS264527.1

Parabacteroides merdae

217241
217831

NZ_DS264563.1

Bacteroides ovatus

4980
5579

NZ_DS996456.1

Parabacteroides johnsonii

597619
598122

NZ_EQ973488.1

Bacteroides cellulosilyticus

180842
180255

NZ_GG688325.1

Bacteroides finegoldii

190680
191279

NZ_JGDE01000119.1

Bacteroides fragilis

11369
10770

NZ_JH370372.1

Alistipes indistinctus

150396
149821

NZ_JH724294.1

Bacteroides xylanisolvens

1356697
1357296

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2041862
2042461

NZ_PUEP01000005.1

Bacteroides ovatus

2145744
2145145

NZ_PUEQ01000003.1

Bacteroides caccae

1764349
1763750

NZ_UFTH01000001.1

Bacteroides fragilis

250655
250056

QEKH01000037.1

Victivallis vadensis

41431
42000

BT_1192

225
462

COLAER_00815

63
152

CVOZ01000044.1

Bacteroides thetaiotaomicron

36179
35082

NZ_ABJL02000008.1

Bacteroides intestinalis

751517
750519

NZ_ACCL02000009.1

Marvinbryantia formatexigens

60051
59242

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

225054
224056

NZ_CVOY01000094.1

Bacteroides thetaiotaomicron

5257
4160

NZ_EQ973492.1

Bacteroides cellulosilyticus

68742
69740

NZ_GG693664.1

Lactobacillus reuteri

69369
68959

NZ_GG703857.1

Prevotella copri

120565
119489

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2345451
2344354

BACDOR_00665

17
220

BT_4075

18
237

BT_4096

15
233

CVOZ01000033.1

Bacteroides thetaiotaomicron

61351
60695

CVOZ01000033.1

Bacteroides thetaiotaomicron

99554
98895

CVOZ01000053.1

Bacteroides thetaiotaomicron

57335
56628

JGCP01002366.1

Bacteroides fragilis

7385
6810

JGCP01002441.1

Bacteroides fragilis

9886
10419

JGCP01002552.1

Bacteroides fragilis

31062
31763

NC_009614.1

Bacteroides vulgatus

5100285
5099674

NC_009615.1

Parabacteroides distasonis

1134973
1135647

NC_009615.1

Parabacteroides distasonis

3795095
3795700

NZ_AAVM02000001.1

Bacteroides caccae

1240752
1240264

NZ_AAYG02000020.1

Ruminococcus gnavus

146634
146014

NZ_ABJL02000006.1

Bacteroides intestinalis

363959
364528

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

142540
143115

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

11055
11711

NZ_CVOY01000005.1

Bacteroides thetaiotaomicron

209350
210054

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

27372
26713

NZ_DS264582.1

Bacteroides ovatus

46805
46104

NZ_DS362220.1

Bacteroides uniformis

17220
16552

NZ_DS362220.1

Bacteroides uniformis

323305
322706

NZ_DS362233.1

Bacteroides uniformis

68158
68733

NZ_DS995510.1

Bacteroides eggerthii

656648
657349

NZ_DS995531.1

Bacteroides dorei

447861
448472

NZ_EQ973490.1

Bacteroides cellulosilyticus

916393
917094

NZ_EQ973490.1

Bacteroides cellulosilyticus

257437
258012

NZ_GG688322.1

Bacteroides finegoldii

129507
130208

NZ_JGDE01000017.1

Bacteroides fragilis

7446
6871

NZ_JGDE01000072.1

Bacteroides fragilis

9365
9898

NZ_JGDE01000136.1

Bacteroides fragilis

27192
27893

NZ_JH370372.1

Alistipes indistinctus

98423
97836

NZ_JH724294.1

Bacteroides xylanisolvens

2429590
2428892

NZ_JH724294.1

Bacteroides xylanisolvens

357558
358211

NZ_MTWC01000003.1

Clostridioides difficile

1624066
1624641

NZ_MTWD01000001.1

Clostridioides difficile

1671881
1672456

NZ_MTWE01000004.1

Clostridioides difficile

1376453
1377028

NZ_PUEL01000004.1

Ruminococcus gnavus

1632369
1631749

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2506871
2507578

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

877155
877811

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

838952
839611

NZ_PUEP01000005.1

Bacteroides ovatus

917568
918269

NZ_PUEQ01000003.1

Bacteroides caccae

1529561
1529073

NZ_UFTH01000001.1

Bacteroides fragilis

1188601
1189302

NZ_UFTH01000001.1

Bacteroides fragilis

4050588
4051193

NZ_UFTH01000001.1

Bacteroides fragilis

2389555
2388980

QEKH01000001.1

Victivallis vadensis

111269
110676

QEKH01000033.1

Victivallis vadensis

30181
29585

BACDOR_03988

47
114

BT_1148

1
64

COLAER_01707

1
61

CVOZ01000045.1

Bacteroides thetaiotaomicron

71534
72259

JGCP01002519.1

Bacteroides fragilis

4300
3575

NC_009614.1

Bacteroides vulgatus

2641382
2642107

NC_009615.1

Parabacteroides distasonis

3958482
3959207

NZ_ABJL02000008.1

Bacteroides intestinalis

196383
195658

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

165083
165808

NZ_CVOY01000055.1

Bacteroides thetaiotaomicron

66645
67370

NZ_EQ973492.1

Bacteroides cellulosilyticus

685757
686482

NZ_JGDE01000121.1

Bacteroides fragilis

3841
3116

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3056168
3055443

NZ_UFTH01000001.1

Bacteroides fragilis

475905
475180

BACDOR_00571

1
161

BACDOR_03988

38
188

BT_1006

1
62

COLAER_01707

2
173

CVOZ01000022.1

Bacteroides thetaiotaomicron

97011
97409

CVOZ01000044.1

Bacteroides thetaiotaomicron

270166
270732

CVOZ01000058.1

Bacteroides thetaiotaomicron

90387
90851

JGCP01000803.1

Bacteroides fragilis

3189
3539

JGCP01001429.1

Bacteroides fragilis

368
33

JGCP01002451.1

Bacteroides fragilis

27266
27829

JGCP01002513.1

Bacteroides fragilis

8383
8045

JGCP01002532.1

Bacteroides fragilis

1981
1547

NC_000913.3

Escherichia coli

1848673
1848173

NC_009614.1

Bacteroides vulgatus

1289411
1288926

NC_009614.1

Bacteroides vulgatus

3238587
3238135

NC_009614.1

Bacteroides vulgatus

2553354
2553794

NC_009614.1

Bacteroides vulgatus

3195969
3196346

NC_009615.1

Parabacteroides distasonis

185234
184872

NC_009615.1

Parabacteroides distasonis

2044480
2044818

NC_009615.1

Parabacteroides distasonis

178506
178946

NC_012781.1

Eubacterium rectale

1600351
1600812

NZ_AAVM02000001.1

Bacteroides caccae

1119739
1119173

NZ_AAVM02000004.1

Bacteroides caccae

244931
245413

NZ_AAVM02000006.1

Bacteroides caccae

117419
117811

NZ_AAVN02000007.1

Collinsella aerofaciens

43331
42861

NZ_AAXA02000015.1

Dorea formicigenerans

428149
428610

NZ_AAXA02000015.1

Dorea formicigenerans

92548
92081

NZ_AAXA02000015.1

Dorea formicigenerans

812479
812928

NZ_AAYG02000005.1

Ruminococcus gnavus

169541
170062

NZ_ABJL02000007.1

Bacteroides intestinalis

959657
959169

NZ_ABJL02000008.1

Bacteroides intestinalis

574722
574159

NZ_ABJL02000008.1

Bacteroides intestinalis

1297560
1297120

NZ_ABJL02000008.1

Bacteroides intestinalis

1656580
1656089

NZ_ABXA01000011.1

Anaerococcus hydrogenalis

17304
16843

NZ_ABXA01000037.1

Anaerococcus hydrogenalis

15306
14824

NZ_ABXW01000046.1

Providencia alcalifaciens

53440
52970

NZ_ACCL02000007.1

Marvinbryantia formatexigens

30293
30754

NZ_ACEP01000002.1

Eubacterium hallii

34252
34719

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1579908
1579426

NZ_ATFI01000002.1

Bacteroides cellulosilyticus

1189
698

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

572171
572605

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

389868
390314

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

229474
229914

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

48939
48385

NZ_CVOY01000018.1

Bacteroides thetaiotaomicron

29468
29866

NZ_CVOY01000040.1

Bacteroides thetaiotaomicron

40321
39857

NZ_CVOY01000048.1

Bacteroides thetaiotaomicron

31356
31922

NZ_DS264270.1

Eubacterium ventriosum

212229
212735

NZ_DS264519.1

Parabacteroides merdae

6745
7185

NZ_DS264542.1

Parabacteroides merdae

249186
248728

NZ_DS264546.1

Parabacteroides merdae

3190
2741

NZ_DS264582.1

Bacteroides ovatus

368669
369235

NZ_DS264583.1

Bacteroides ovatus

339925
339533

NZ_DS362240.1

Bacteroides uniformis

130419
130859

NZ_DS362244.1

Bacteroides uniformis

170466
171023

NZ_DS362248.1

Bacteroides uniformis

308148
308636

NZ_DS480690.1

Clostridium bolteae

244847
244389

NZ_DS480690.1

Clostridium bolteae

89559
89996

NZ_DS480692.1

Clostridium bolteae

142191
141730

NZ_DS480699.1

Clostridium bolteae

65753
65265

NZ_DS480702.1

Clostridium bolteae

207090
207605

NZ_DS499655.1

Erysipelatoclostridium ramosum

354515
355066

NZ_DS499657.1

Erysipelatoclostridium ramosum

40329
39883

NZ_DS499659.1

Erysipelatoclostridium ramosum

548777
548307

NZ_DS499671.1

Bacteroides stercoris

218970
218503

NZ_DS499672.1

Bacteroides stercoris

113148
113708

NZ_DS499673.1

Bacteroides stercoris

148976
149359

NZ_DS499674.1

Bacteroides stercoris

145533
146009

NZ_DS499697.1

Clostridium scindens

325331
325762

NZ_DS499701.1

Clostridium scindens

43475
43014

NZ_DS544193.1

Anaerotruncus colihominis

200255
200710

NZ_DS562846.1

Clostridium spiroforme

146415
145894

NZ_DS562853.1

Clostridium spiroforme

140554
141045

NZ_DS981517.1

Clostridium sporogenes

2367337
2367828

NZ_DS981517.1

Clostridium sporogenes

1671572
1672009

NZ_DS981517.1

Clostridium sporogenes

557155
557655

NZ_DS981518.1

Clostridium sporogenes

1189250
1189702

NZ_DS990201.1

Ruminococcus lactaris

50102
50560

NZ_DS995509.1

Bacteroides eggerthii

1232487
1232954

NZ_DS995510.1

Bacteroides eggerthii

730874
731431

NZ_DS995510.1

Bacteroides eggerthii

106160
106552

NZ_DS995511.1

Bacteroides eggerthii

244985
245470

NZ_DS995534.1

Bacteroides dorei

71655
71170

NZ_DS995536.1

Bacteroides dorei

38613
38173

NZ_DS995537.1

Bacteroides dorei

674823
674371

NZ_DS995537.1

Bacteroides dorei

634364
634741

NZ_DS996445.1

Parabacteroides johnsonii

6103
6543

NZ_DS996446.1

Parabacteroides johnsonii

59125
59583

NZ_DS996841.1

Holdemanella biformis

240826
240371

NZ_DS996847.1

Holdemanella biformis

35961
36428

NZ_DS996921.1

Bacteroides pectinophilus

1377567
1378028

NZ_EQ973488.1

Bacteroides cellulosilyticus

47293
46802

NZ_EQ973490.1

Bacteroides cellulosilyticus

1771271
1770789

NZ_EQ973491.1

Bacteroides cellulosilyticus

190369
189923

NZ_EQ973492.1

Bacteroides cellulosilyticus

269760
270314

NZ_EQ973495.1

Bacteroides cellulosilyticus

467156
466716

NZ_EQ973631.1

Bacteroides coprophilus

166054
166542

NZ_EQ973635.1

Bacteroides coprophilus

157971
157459

NZ_EQ973650.1

Bacteroides coprophilus

309687
310166

NZ_EQ973651.1

Bacteroides coprophilus

186897
186505

NZ_GG657592.1

Clostridium asparagiforme

256642
256181

NZ_GG657592.1

Clostridium asparagiforme

2004031
2003507

NZ_GG662012.1

Coprococcus comes

43447
42971

NZ_GG662014.1

Coprococcus comes

263238
263699

NZ_GG662014.1

Coprococcus comes

272789
273202

NZ_GG667651.1

Hungatella hathewayi

1938
2414

NZ_GG667669.1

Hungatella hathewayi

6018
5659

NZ_GG688323.1

Bacteroides finegoldii

185586
185020

NZ_GG688331.1

Bacteroides finegoldii

31992
32390

NZ_GG688334.1

Bacteroides finegoldii

50704
51138

NZ_GG688343.1

Bacteroides finegoldii

10043
9534

NZ_GG692721.1

Roseburia intestinalis

15570
16028

NZ_GG692723.1

Roseburia intestinalis

45141
44704

NZ_GG698588.1

Blautia hansenii

717392
717745

NZ_GG698590.1

Blautia hansenii

424876
424454

NZ_GG698591.1

Blautia hansenii

291860
291414

NZ_GG703859.1

Prevotella copri

138304
138762

NZ_GG704769.1

Subdoligranulum variabile

1245795
1245319

NZ_GG704863.1

Enterobacter cancerogenus

743021
743521

NZ_GG705262.1

Providencia rettgeri

266718
267200

NZ_JGDE01000083.1

Bacteroides fragilis

52773
53336

NZ_JGDE01000119.1

Bacteroides fragilis

36826
36488

NZ_JGDE01000120.1

Bacteroides fragilis

100596
100204

NZ_JGDE01000126.1

Bacteroides fragilis

19690
19256

NZ_JH370371.1

Alistipes indistinctus

1289797
1289312

NZ_JH724294.1

Bacteroides xylanisolvens

1743271
1743837

NZ_JH724294.1

Bacteroides xylanisolvens

1305671
1306153

NZ_JH724298.1

Bacteroides xylanisolvens

164868
165341

NZ_KE993038.1

Clostridium symbiosum

28568
29044

NZ_MTWC01000003.1

Clostridioides difficile

764209
764835

NZ_MTWC01000003.1

Clostridioides difficile

851741
852184

NZ_MTWC01000003.1

Clostridioides difficile

2732784
2732185

NZ_MTWC01000003.1

Clostridioides difficile

699115
699672

NZ_MTWC01000003.1

Clostridioides difficile

183072
182623

NZ_MTWC01000003.1

Clostridioides difficile

3541722
3542282

NZ_MTWD01000001.1

Clostridioides difficile

864267
864893

NZ_MTWD01000001.1

Clostridioides difficile

951757
952200

NZ_MTWD01000001.1

Clostridioides difficile

2768710
2768111

NZ_MTWD01000001.1

Clostridioides difficile

797509
798066

NZ_MTWD01000001.1

Clostridioides difficile

272107
271658

NZ_MTWD01000001.1

Clostridioides difficile

3546771
3547331

NZ_MTWE01000004.1

Clostridioides difficile

3086150
3086647

NZ_MTWE01000004.1

Clostridioides difficile

644551
645006

NZ_MTWE01000004.1

Clostridioides difficile

562099
562725

NZ_MTWE01000004.1

Clostridioides difficile

2485446
2484847

NZ_MTWE01000004.1

Clostridioides difficile

496166
496723

NZ_MTWE01000004.1

Clostridioides difficile

3212349
3212909

NZ_MTWF01000010.1

Clostridioides difficile

451157
451783

NZ_MTWF01000010.1

Clostridioides difficile

538758
539201

NZ_MTWF01000010.1

Clostridioides difficile

384824
385381

NZ_MTWF01000021.1

Clostridioides difficile

587932
588492

NZ_PPUH01000002.1

Eggerthella lenta

235526
235999

NZ_PUEL01000004.1

Ruminococcus gnavus

215279
214758

NZ_PUEM01000006.1

Clostridium bolteae

4914475
4914017

NZ_PUEM01000006.1

Clostridium bolteae

4326884
4327345

NZ_PUEM01000006.1

Clostridium bolteae

105784
105296

NZ_PUEM01000006.1

Clostridium bolteae

4759191
4759628

NZ_PUEM01000006.1

Clostridium bolteae

3928704
3928189

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3235803
3235237

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3874992
3874594

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1992632
1993096

NZ_PUEP01000005.1

Bacteroides ovatus

1680440
1679874

NZ_PUEP01000005.1

Bacteroides ovatus

2195804
2195322

NZ_PUEP01000005.1

Bacteroides ovatus

164842
165234

NZ_PUEP01000005.1

Bacteroides ovatus

562300
561950

NZ_PUEQ01000002.1

Bacteroides caccae

164477
164869

NZ_PUEQ01000003.1

Bacteroides caccae

1408550
1407984

NZ_PUEQ01000003.1

Bacteroides caccae

1805544
1805062

NZ_UFTH01000001.1

Bacteroides fragilis

4377465
4378028

NZ_UFTH01000001.1

Bacteroides fragilis

384961
384569

NZ_UFTH01000001.1

Bacteroides fragilis

276111
275773

NZ_UFTH01000001.1

Bacteroides fragilis

627434
627000

QEKH01000007.1

Victivallis vadensis

148157
147966

QEKH01000020.1

Victivallis vadensis

34991
35440

BACDOR_03642

199
294

BT_0445

108
355

BT_3112

198
273

BT_4096

25
227

COLAER_00311

4
141

COLAER_01894

100
223

CVOZ01000002.1

Bacteroides thetaiotaomicron

27517
28095

CVOZ01000022.1

Bacteroides thetaiotaomicron

18764
19381

CVOZ01000033.1

Bacteroides thetaiotaomicron

94159
93596

CVOZ01000044.1

Bacteroides thetaiotaomicron

154575
155963

CVOZ01000044.1

Bacteroides thetaiotaomicron

288279
287539

CVOZ01000044.1

Bacteroides thetaiotaomicron

54111
54704

CVOZ01000045.1

Bacteroides thetaiotaomicron

69771
70430

JGCP01000579.1

Bacteroides fragilis

101
835

JGCP01001396.1

Bacteroides fragilis

73
648

JGCP01001597.1

Bacteroides fragilis

35746
35105

JGCP01001863.1

Bacteroides fragilis

3013
2438

JGCP01002141.1

Bacteroides fragilis

80
562

JGCP01002441.1

Bacteroides fragilis

10488
11063

JGCP01002451.1

Bacteroides fragilis

42494
41802

JGCP01002459.1

Bacteroides fragilis

73942
74622

NC_008618.1

Bifidobacterium adolescentis

551869
551261

NC_008618.1

Bifidobacterium adolescentis

1949407
1950006

NC_009614.1

Bacteroides vulgatus

768330
769709

NC_009614.1

Bacteroides vulgatus

3519215
3518526

NC_009614.1

Bacteroides vulgatus

5099605
5099030

NC_009615.1

Parabacteroides distasonis

2089648
2090340

NC_009615.1

Parabacteroides distasonis

3529426
3530001

NC_009615.1

Parabacteroides distasonis

421342
422067

NC_010655.1

Akkermansia muciniphila

236748
237500

NC_010655.1

Akkermansia muciniphila

1519934
1520518

NC_010655.1

Akkermansia muciniphila

543429
544073

NZ_AAVM02000001.1

Bacteroides caccae

1170612
1169452

NZ_AAVM02000001.1

Bacteroides caccae

1240152
1239577

NZ_AAVM02000001.1

Bacteroides caccae

1169494
1169237

NZ_AAVN02000002.1

Collinsella aerofaciens

333786
333019

NZ_AAVN02000003.1

Collinsella aerofaciens

209264
210085

NZ_AAXA02000013.1

Dorea formicigenerans

16343
17014

NZ_ABJL02000007.1

Bacteroides intestinalis

1098860
1099444

NZ_ABJL02000008.1

Bacteroides intestinalis

382787
383479

NZ_ACCL02000033.1

Marvinbryantia formatexigens

12876
12274

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1683794
1684420

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1683052
1683747

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1782879
1783463

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1678134
1678772

NZ_ATFI01000003.1

Bacteroides cellulosilyticus

171894
171202

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

21976
21413

NZ_CVOY01000035.1

Bacteroides thetaiotaomicron

60758
62146

NZ_CVOY01000041.1

Bacteroides thetaiotaomicron

67133
66540

NZ_CVOY01000048.1

Bacteroides thetaiotaomicron

49341
48601

NZ_CVOY01000055.1

Bacteroides thetaiotaomicron

64881
65540

NZ_CVOY01000056.1

Bacteroides thetaiotaomicron

28539
27919

NZ_DS264285.1

Eubacterium ventriosum

234482
233679

NZ_DS264345.1

Ruminococcus torques

463019
463708

NZ_DS264358.1

Ruminococcus torques

67993
67382

NZ_DS264461.1

Parabacteroides merdae

326010
326663

NZ_DS264517.1

Parabacteroides merdae

22263
22925

NZ_DS264542.1

Parabacteroides merdae

81508
82206

NZ_DS264546.1

Parabacteroides merdae

423018
422293

NZ_DS264582.1

Bacteroides ovatus

312464
313840

NZ_DS264582.1

Bacteroides ovatus

385872
385138

NZ_DS264584.1

Bacteroides ovatus

360662
360078

NZ_DS362246.1

Bacteroides uniformis

266126
266818

NZ_DS480676.1

Clostridium bolteae

34484
35167

NZ_DS499671.1

Bacteroides stercoris

178076
178768

NZ_DS499699.1

Clostridium scindens

152903
153694

NZ_DS990204.1

Ruminococcus lactaris

12440
11805

NZ_DS990238.1

Bifidobacterium longum

835334
835945

NZ_DS995510.1

Bacteroides eggerthii

1068518
1069210

NZ_DS995531.1

Bacteroides dorei

448541
449116

NZ_DS995532.1

Bacteroides dorei

204439
203063

NZ_DS995537.1

Bacteroides dorei

1066363
1065647

NZ_DS996444.1

Parabacteroides johnsonii

692206
692904

NZ_DS996444.1

Parabacteroides johnsonii

534772
535347

NZ_DS996445.1

Parabacteroides johnsonii

312362
312937

NZ_DS996445.1

Parabacteroides johnsonii

311498
312121

NZ_DS996453.1

Parabacteroides johnsonii

2533
1928

NZ_DS996454.1

Parabacteroides johnsonii

206111
205386

NZ_DS996921.1

Bacteroides pectinophilus

286605
285892

NZ_DS996921.1

Bacteroides pectinophilus

2101527
2100832

NZ_EQ973490.1

Bacteroides cellulosilyticus

1876241
1876867

NZ_EQ973490.1

Bacteroides cellulosilyticus

1875499
1876194

NZ_EQ973490.1

Bacteroides cellulosilyticus

1993710
1994294

NZ_EQ973490.1

Bacteroides cellulosilyticus

1870581
1871219

NZ_EQ973492.1

Bacteroides cellulosilyticus

515707
515015

NZ_EQ973635.1

Bacteroides coprophilus

234153
233497

NZ_EQ973643.1

Bacteroides coprophilus

430594
431154

NZ_EQ973645.1

Bacteroides coprophilus

64093
64677

NZ_GG657587.1

Clostridium asparagiforme

608304
607693

NZ_GG688324.1

Bacteroides finegoldii

240097
241473

NZ_GG692719.1

Roseburia intestinalis

133882
133238

NZ_GG692722.1

Roseburia intestinalis

102286
101618

NZ_GG698591.1

Blautia hansenii

190916
190320

NZ_GG703852.1

Prevotella copri

38955
39719

NZ_GG704769.1

Subdoligranulum variabile

1468443
1469039

NZ_JGDE01000072.1

Bacteroides fragilis

9967
10542

NZ_JGDE01000083.1

Bacteroides fragilis

68003
67311

NZ_JGDE01000090.1

Bacteroides fragilis

28577
29257

NZ_JGDE01000151.1

Bacteroides fragilis

44141
43500

NZ_JH370371.1

Alistipes indistinctus

1345780
1345082

NZ_JH370371.1

Alistipes indistinctus

1448027
1447329

NZ_JH370371.1

Alistipes indistinctus

1079496
1078762

NZ_JH370372.1

Alistipes indistinctus

982398
983033

NZ_JH724294.1

Bacteroides xylanisolvens

1686417
1687793

NZ_JH724294.1

Bacteroides xylanisolvens

1760534
1759800

NZ_JH724300.1

Bacteroides xylanisolvens

30471
31202

NZ_PUEL01000004.1

Ruminococcus gnavus

1481589
1480987

NZ_PUEM01000006.1

Clostridium bolteae

1700445
1699762

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

234534
233911

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

909823
909245

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3291162
3289774

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3176085
3176825

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3057931
3057272

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

844348
844911

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2363382
2363975

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3953243
3952623

NZ_PUEP01000005.1

Bacteroides ovatus

1736646
1735270

NZ_PUEP01000005.1

Bacteroides ovatus

1663236
1663970

NZ_PUEP01000005.1

Bacteroides ovatus

3085087
3085671

NZ_PUEQ01000003.1

Bacteroides caccae

1459423
1458263

NZ_PUEQ01000003.1

Bacteroides caccae

1528961
1528386

NZ_PUEQ01000003.1

Bacteroides caccae

1458305
1458048

NZ_UFTH01000001.1

Bacteroides fragilis

4392695
4392003

NZ_UFTH01000001.1

Bacteroides fragilis

1560134
1559493

NZ_UFTH01000001.1

Bacteroides fragilis

4539896
4540576

NZ_UFTH01000001.1

Bacteroides fragilis

4051262
4051837

QEKH01000002.1

Victivallis vadensis

212329
213045

QEKH01000007.1

Victivallis vadensis

28585
27923

QEKH01000045.1

Victivallis vadensis

12920
13444

QEKH01000049.1

Victivallis vadensis

19550
18807

CVOZ01000063.1

Bacteroides thetaiotaomicron

94029
94442

CVOZ01000063.1

Bacteroides thetaiotaomicron

147334
147705

JGCP01000058.1

Bacteroides fragilis

518
925

JGCP01002489.1

Bacteroides fragilis

518
925

JGCP01002505.1

Bacteroides fragilis

555
148

NC_009614.1

Bacteroides vulgatus

910468
910875

NC_009615.1

Parabacteroides distasonis

2405517
2405906

NZ_AAVM02000005.1

Bacteroides caccae

97107
97520

NZ_AAVM02000005.1

Bacteroides caccae

155081
155452

NZ_ABJL02000008.1

Bacteroides intestinalis

642857
643258

NZ_ABJL02000008.1

Bacteroides intestinalis

2029709
2030089

NZ_ABJL02000008.1

Bacteroides intestinalis

1716117
1715746

NZ_ATFI01000002.1

Bacteroides cellulosilyticus

74483
74112

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

122628
123029

NZ_CVOY01000013.1

Bacteroides thetaiotaomicron

191727
192140

NZ_CVOY01000058.1

Bacteroides thetaiotaomicron

28964
28593

NZ_DS264541.1

Parabacteroides merdae

67177
66776

NZ_DS362236.1

Bacteroides uniformis

38489
38878

NZ_DS362245.1

Bacteroides uniformis

24062
24184

NZ_DS362245.1

Bacteroides uniformis

24267
24356

NZ_DS362245.1

Bacteroides uniformis

24193
24264

NZ_DS480694.1

Clostridium bolteae

252033
252386

NZ_DS499718.1

Clostridium scindens

309983
309654

NZ_DS995528.1

Bacteroides dorei

127411
127812

NZ_DS995533.1

Bacteroides dorei

131728
131327

NZ_DS996447.1

Parabacteroides johnsonii

92123
91722

NZ_DS996455.1

Parabacteroides johnsonii

41510
41118

NZ_DS996455.1

Parabacteroides johnsonii

41091
40711

NZ_EQ973488.1

Bacteroides cellulosilyticus

155148
154777

NZ_EQ973492.1

Bacteroides cellulosilyticus

200913
200512

NZ_GG657592.1

Clostridium asparagiforme

560671
561042

NZ_GG667665.1

Hungatella hathewayi

3412
3059

NZ_GG688317.1

Bacteroides finegoldii

373129
372716

NZ_GG688317.1

Bacteroides finegoldii

351401
351003

NZ_JGDE01000115.1

Bacteroides fragilis

2024
1617

NZ_JH370371.1

Alistipes indistinctus

1113682
1114062

NZ_JH724297.1

Bacteroides xylanisolvens

171556
171143

NZ_JH724297.1

Bacteroides xylanisolvens

107227
106856

NZ_PUEM01000006.1

Clostridium bolteae

5784734
5784381

NZ_AAVN02000003.1

Collinsella aerofaciens

209264
210085

NZ_AAXA02000013.1

Dorea formicigenerans

16343
17014

NZ_ABJL02000007.1

Bacteroides intestinalis

1098860
1099444

NZ_ABJL02000008.1

Bacteroides intestinalis

382787
383479

NZ_ACCL02000033.1

Marvinbryantia formatexigens

12876
12274

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1683794
1684420

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1683052
1683747

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1782879
1783463

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1678134
1678772

NZ_ATFI01000003.1

Bacteroides cellulosilyticus

171894
171202

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

21976
21413

NZ_CVOY01000035.1

Bacteroides thetaiotaomicron

60758
62146

NZ_CVOY01000041.1

Bacteroides thetaiotaomicron

67133
66540

NZ_CVOY01000048.1

Bacteroides thetaiotaomicron

49341
48601

NZ_CVOY01000055.1

Bacteroides thetaiotaomicron

64881
65540

NZ_CVOY01000056.1

Bacteroides thetaiotaomicron

28539
27919

NZ_DS264285.1

Eubacterium ventriosum

234482
233679

NZ_DS264345.1

Ruminococcus torques

463019
463708

NZ_DS264358.1

Ruminococcus torques

67993
67382

NZ_DS264461.1

Parabacteroides merdae

326010
326663

NZ_DS264517.1

Parabacteroides merdae

22263
22925

NZ_DS264542.1

Parabacteroides merdae

81508
82206

NZ_DS264546.1

Parabacteroides merdae

423018
422293

NZ_DS264582.1

Bacteroides ovatus

312464
313840

NZ_DS264582.1

Bacteroides ovatus

385872
385138

NZ_DS264584.1

Bacteroides ovatus

360662
360078

NZ_DS362246.1

Bacteroides uniformis

266126
266818

NZ_DS480676.1

Clostridium bolteae

34484
35167

NZ_DS499671.1

Bacteroides stercoris

178076
178768

NZ_DS499699.1

Clostridium scindens

152903
153694

NZ_DS990204.1

Ruminococcus lactaris

12440
11805

NZ_DS990238.1

Bifidobacterium longum

835334
835945

NZ_DS995510.1

Bacteroides eggerthii

1068518
1069210

NZ_DS995531.1

Bacteroides dorei

448541
449116

NZ_DS995532.1

Bacteroides dorei

204439
203063

NZ_DS995537.1

Bacteroides dorei

1066363
1065647

NZ_DS996444.1

Parabacteroides johnsonii

692206
692904

NZ_DS996444.1

Parabacteroides johnsonii

534772
535347

NZ_DS996445.1

Parabacteroides johnsonii

312362
312937

NZ_DS996445.1

Parabacteroides johnsonii

311498
312121

NZ_DS996453.1

Parabacteroides johnsonii

2533
1928

NZ_DS996454.1

Parabacteroides johnsonii

206111
205386

NZ_DS996921.1

Bacteroides pectinophilus

286605
285892

NZ_DS996921.1

Bacteroides pectinophilus

2101527
2100832

NZ_EQ973490.1

Bacteroides cellulosilyticus

1876241
1876867

NZ_EQ973490.1

Bacteroides cellulosilyticus

1875499
1876194

NZ_EQ973490.1

Bacteroides cellulosilyticus

1993710
1994294

NZ_EQ973490.1

Bacteroides cellulosilyticus

1870581
1871219

NZ_EQ973492.1

Bacteroides cellulosilyticus

515707
515015

NZ_EQ973635.1

Bacteroides coprophilus

234153
233497

NZ_EQ973643.1

Bacteroides coprophilus

430594
431154

NZ_EQ973645.1

Bacteroides coprophilus

64093
64677

NZ_GG657587.1

Clostridium asparagiforme

608304
607693

NZ_GG688324.1

Bacteroides finegoldii

240097
241473

NZ_GG692719.1

Roseburia intestinalis

133882
133238

NZ_GG692722.1

Roseburia intestinalis

102286
101618

NZ_GG698591.1

Blautia hansenii

190916
190320

NZ_GG703852.1

Prevotella copri

38955
39719

NZ_GG704769.1

Subdoligranulum variabile

1468443
1469039

NZ_JGDE01000072.1

Bacteroides fragilis

9967
10542

NZ_JGDE01000083.1

Bacteroides fragilis

68003
67311

NZ_JGDE01000090.1

Bacteroides fragilis

28577
29257

NZ_JGDE01000151.1

Bacteroides fragilis

44141
43500

NZ_JH370371.1

Alistipes indistinctus

1345780
1345082

NZ_JH370371.1

Alistipes indistinctus

1448027
1447329

NZ_JH370371.1

Alistipes indistinctus

1079496
1078762

NZ_JH370372.1

Alistipes indistinctus

982398
983033

NZ_JH724294.1

Bacteroides xylanisolvens

1686417
1687793

NZ_JH724294.1

Bacteroides xylanisolvens

1760534
1759800

NZ_JH724300.1

Bacteroides xylanisolvens

30471
31202

NZ_PUEL01000004.1

Ruminococcus gnavus

1481589
1480987

NZ_PUEM01000006.1

Clostridium bolteae

1700445
1699762

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

234534
233911

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

909823
909245

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3291162
3289774

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3176085
3176825

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3057931
3057272

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

844348
844911

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2363382
2363975

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3953243
3952623

NZ_PUEP01000005.1

Bacteroides ovatus

1736646
1735270

NZ_PUEP01000005.1

Bacteroides ovatus

1663236
1663970

NZ_PUEP01000005.1

Bacteroides ovatus

3085087
3085671

NZ_PUEQ01000003.1

Bacteroides caccae

1459423
1458263

NZ_PUEQ01000003.1

Bacteroides caccae

1528961
1528386

NZ_PUEQ01000003.1

Bacteroides caccae

1458305
1458048

NZ_UFTH01000001.1

Bacteroides fragilis

4392695
4392003

NZ_UFTH01000001.1

Bacteroides fragilis

1560134
1559493

NZ_UFTH01000001.1

Bacteroides fragilis

4539896
4540576

NZ_UFTH01000001.1

Bacteroides fragilis

4051262
4051837

QEKH01000002.1

Victivallis vadensis

212329
213045

QEKH01000007.1

Victivallis vadensis

28585
27923

QEKH01000045.1

Victivallis vadensis

12920
13444

QEKH01000049.1

Victivallis vadensis

19550
18807

CVOZ01000063.1

Bacteroides thetaiotaomicron

94029
94442

CVOZ01000063.1

Bacteroides thetaiotaomicron

147334
147705

JGCP01000058.1

Bacteroides fragilis

518
925

JGCP01002489.1

Bacteroides fragilis

518
925

JGCP01002505.1

Bacteroides fragilis

555
148

NC_009614.1

Bacteroides vulgatus

910468
910875

NC_009615.1

Parabacteroides distasonis

2405517
2405906

NZ_AAVM02000005.1

Bacteroides caccae

97107
97520

NZ_AAVM02000005.1

Bacteroides caccae

155081
155452

NZ_ABJL02000008.1

Bacteroides intestinalis

642857
643258

NZ_ABJL02000008.1

Bacteroides intestinalis

2029709
2030089

NZ_ABJL02000008.1

Bacteroides intestinalis

1716117
1715746

NZ_ATFI01000002.1

Bacteroides cellulosilyticus

74483
74112

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

122628
123029

NZ_CVOY01000013.1

Bacteroides thetaiotaomicron

191727
192140

NZ_CVOY01000058.1

Bacteroides thetaiotaomicron

28964
28593

NZ_DS264541.1

Parabacteroides merdae

67177
66776

NZ_DS362236.1

Bacteroides uniformis

38489
38878

NZ_DS362245.1

Bacteroides uniformis

24062
24184

NZ_DS362245.1

Bacteroides uniformis

24267
24356

NZ_DS362245.1

Bacteroides uniformis

24193
24264

NZ_DS480694.1

Clostridium bolteae

252033
252386

NZ_DS499718.1

Clostridium scindens

309983
309654

NZ_DS995528.1

Bacteroides dorei

127411
127812

NZ_DS995533.1

Bacteroides dorei

131728
131327

NZ_DS996447.1

Parabacteroides johnsonii

92123
91722

NZ_DS996455.1

Parabacteroides johnsonii

41510
41118

NZ_DS996455.1

Parabacteroides johnsonii

41091
40711

NZ_EQ973488.1

Bacteroides cellulosilyticus

155148
154777

NZ_EQ973492.1

Bacteroides cellulosilyticus

200913
200512

NZ_GG657592.1

Clostridium asparagiforme

560671
561042

NZ_GG667665.1

Hungatella hathewayi

3412
3059

NZ_GG688317.1

Bacteroides finegoldii

373129
372716

NZ_GG688317.1

Bacteroides finegoldii

351401
351003

NZ_JGDE01000115.1

Bacteroides fragilis

2024
1617

NZ_JH370371.1

Alistipes indistinctus

1113682
1114062

NZ_JH724297.1

Bacteroides xylanisolvens

171556
171143

NZ_JH724297.1

Bacteroides xylanisolvens

107227
106856

NZ_PUEM01000006.1

Clostridium bolteae

5784734
5784381

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3563261
3562848

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3514703
3514332

NZ_PUEP01000005.1

Bacteroides ovatus

528515
528928

NZ_PUEQ01000002.1

Bacteroides caccae

463991
464404

NZ_PUEQ01000002.1

Bacteroides caccae

521965
522336

NZ_UFTH01000001.1

Bacteroides fragilis

100554
100147

NZ_UFTH01000001.1

Bacteroides fragilis

3470508
3470128

BACDOR_03091

1
254

CVOZ01000016.1

Bacteroides thetaiotaomicron

213809
214567

JGCP01001391.1

Bacteroides fragilis

1827
1213

JGCP01002541.1

Bacteroides fragilis

59029
58271

NC_009614.1

Bacteroides vulgatus

2545071
2545832

NZ_AAVM02000007.1

Bacteroides caccae

240333
241091

NZ_ABJL02000002.1

Bacteroides intestinalis

14878
14120

NZ_ATFI01000018.1

Bacteroides cellulosilyticus

73581
72838

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

107627
108385

NZ_DS264546.1

Parabacteroides merdae

161605
162363

NZ_DS264580.1

Bacteroides ovatus

422161
422919

NZ_DS362242.1

Bacteroides uniformis

128891
128124

NZ_DS499676.1

Bacteroides stercoris

354507
353740

NZ_DS995508.1

Bacteroides eggerthii

374349
375116

NZ_DS995536.1

Bacteroides dorei

46897
46136

NZ_DS996453.1

Parabacteroides johnsonii

310455
311213

NZ_EQ973489.1

Bacteroides cellulosilyticus

471401
472159

NZ_EQ973643.1

Bacteroides coprophilus

27626
28387

NZ_GG688318.1

Bacteroides finegoldii

85948
85178

NZ_GG688321.1

Bacteroides finegoldii

185788
185030

NZ_JGDE01000131.1

Bacteroides fragilis

10637
9879

NZ_JH370372.1

Alistipes indistinctus

247942
248700

NZ_JH724296.1

Bacteroides xylanisolvens

113928
113170

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

447878
448636

NZ_PUEP01000015.1

Bacteroides ovatus

275761
276519

NZ_PUEQ01000003.1

Bacteroides caccae

478198
478956

NZ_UFTH01000001.1

Bacteroides fragilis

906258
905500

CVOZ01000011.1

Bacteroides thetaiotaomicron

219980
219420

CVOZ01000016.1

Bacteroides thetaiotaomicron

167582
167028

CVOZ01000025.1

Bacteroides thetaiotaomicron

66610
66056

CVOZ01000044.1

Bacteroides thetaiotaomicron

108057
107521

CVOZ01000063.1

Bacteroides thetaiotaomicron

143061
143615

CVOZ01000063.1

Bacteroides thetaiotaomicron

145810
146208

JGCP01000973.1

Bacteroides fragilis

643
92

JGCP01001566.1

Bacteroides fragilis

1249
839

JGCP01002360.1

Bacteroides fragilis

23022
22462

JGCP01002412.1

Bacteroides fragilis

4210
3653

JGCP01002443.1

Bacteroides fragilis

42592
42056

JGCP01002542.1

Bacteroides fragilis

18080
18631

JGCP01002566.1

Bacteroides fragilis

42801
43268

NC_009614.1

Bacteroides vulgatus

3183720
3184280

NC_009614.1

Bacteroides vulgatus

499623
499123

NC_009614.1

Bacteroides vulgatus

4349638
4350111

NC_009614.1

Bacteroides vulgatus

4776064
4775543

NC_009615.1

Parabacteroides distasonis

4127877
4128401

NC_009615.1

Parabacteroides distasonis

2031801
2032322

NC_009615.1

Parabacteroides distasonis

1603192
1602650

NC_009615.1

Parabacteroides distasonis

682204
682719

NC_009615.1

Parabacteroides distasonis

3533129
3533686

NZ_AAVM02000001.1

Bacteroides caccae

189463
188936

NZ_AAVM02000001.1

Bacteroides caccae

1211906
1212442

NZ_AAVM02000005.1

Bacteroides caccae

151298
151846

NZ_AAVM02000006.1

Bacteroides caccae

287613
287059

NZ_AAVM02000010.1

Bacteroides caccae

85074
85634

NZ_ABJL02000008.1

Bacteroides intestinalis

2132288
2132833

NZ_ABJL02000008.1

Bacteroides intestinalis

2131519
2132073

NZ_ABJL02000008.1

Bacteroides intestinalis

679330
679866

NZ_ATFI01000005.1

Bacteroides cellulosilyticus

230282
230836

NZ_ATFI01000005.1

Bacteroides cellulosilyticus

231097
231633

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

321265
320705

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

160096
160632

NZ_CVOY01000001.1

Bacteroides thetaiotaomicron

79232
78672

NZ_CVOY01000013.1

Bacteroides thetaiotaomicron

62072
61518

NZ_CVOY01000030.1

Bacteroides thetaiotaomicron

4322
3768

NZ_CVOY01000035.1

Bacteroides thetaiotaomicron

14717
14181

NZ_CVOY01000058.1

Bacteroides thetaiotaomicron

33237
32683

NZ_CVOY01000058.1

Bacteroides thetaiotaomicron

30488
30090

NZ_DS264546.1

Parabacteroides merdae

78860
79414

NZ_DS264550.1

Parabacteroides merdae

128183
127710

NZ_DS264553.1

Bacteroides ovatus

176225
176785

NZ_DS264580.1

Bacteroides ovatus

123123
122575

NZ_DS264580.1

Bacteroides ovatus

354346
353792

NZ_DS264583.1

Bacteroides ovatus

172043
172597

NZ_DS362220.1

Bacteroides uniformis

32266
32826

NZ_DS362220.1

Bacteroides uniformis

254449
253925

NZ_DS362244.1

Bacteroides uniformis

102221
101685

NZ_DS362249.1

Bacteroides uniformis

419154
418600

NZ_DS362249.1

Bacteroides uniformis

362515
363072

NZ_DS499662.1

Bacteroides stercoris

200073
200540

NZ_DS499670.1

Bacteroides stercoris

42083
41586

NZ_DS499673.1

Bacteroides stercoris

90740
91294

NZ_DS499673.1

Bacteroides stercoris

541813
541277

NZ_DS995510.1

Bacteroides eggerthii

371763
371206

NZ_DS995510.1

Bacteroides eggerthii

628791
628255

NZ_DS995511.1

Bacteroides eggerthii

217868
218320

NZ_DS995528.1

Bacteroides dorei

122323
122823

NZ_DS995531.1

Bacteroides dorei

766509
767030

NZ_DS995537.1

Bacteroides dorei

622118
622678

NZ_DS995537.1

Bacteroides dorei

760012
760485

NZ_DS996445.1

Parabacteroides johnsonii

218590
219132

NZ_DS996453.1

Parabacteroides johnsonii

227358
227912

NZ_EQ973491.1

Bacteroides cellulosilyticus

1248851
1248297

NZ_EQ973491.1

Bacteroides cellulosilyticus

1248036
1247500

NZ_EQ973492.1

Bacteroides cellulosilyticus

842623
842063

NZ_EQ973492.1

Bacteroides cellulosilyticus

135050
134514

NZ_EQ973635.1

Bacteroides coprophilus

258217
257702

NZ_EQ973643.1

Bacteroides coprophilus

609437
609997

NZ_EQ973643.1

Bacteroides coprophilus

520140
520700

NZ_GG688324.1

Bacteroides finegoldii

201991
201455

NZ_GG688326.1

Bacteroides finegoldii

160158
160718

NZ_GG703852.1

Prevotella copri

780182
779757

NZ_JGDE01000045.1

Bacteroides fragilis

38908
38351

NZ_JGDE01000073.1

Bacteroides fragilis

41461
40925

NZ_JGDE01000133.1

Bacteroides fragilis

26430
26981

NZ_JGDE01000148.1

Bacteroides fragilis

50583
51050

NZ_JH724294.1

Bacteroides xylanisolvens

2266949
2266389

NZ_JH724294.1

Bacteroides xylanisolvens

1638830
1638294

NZ_JH724296.1

Bacteroides xylanisolvens

516372
516920

NZ_JH724296.1

Bacteroides xylanisolvens

205601
206155

NZ_JH724297.1

Bacteroides xylanisolvens

108883
108359

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

85768
85208

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

401651
401097

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3707772
3708326

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3518976
3518422

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3337890
3338426

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3516227
3515829

NZ_PUEP01000005.1

Bacteroides ovatus

1141525
1142085

NZ_PUEP01000005.1

Bacteroides ovatus

332723
332169

NZ_PUEP01000005.1

Bacteroides ovatus

5888755
5888207

NZ_PUEP01000005.1

Bacteroides ovatus

1851269
1851805

NZ_PUEP01000015.1

Bacteroides ovatus

207946
207392

NZ_PUEQ01000002.1

Bacteroides caccae

334672
334118

NZ_PUEQ01000002.1

Bacteroides caccae

518182
518730

NZ_PUEQ01000003.1

Bacteroides caccae

2119824
2119264

NZ_PUEQ01000003.1

Bacteroides caccae

3811487
3810960

NZ_PUEQ01000003.1

Bacteroides caccae

1500715
1501251

NZ_UFTH01000001.1

Bacteroides fragilis

2312130
2311570

NZ_UFTH01000001.1

Bacteroides fragilis

1453837
1454397

NZ_UFTH01000001.1

Bacteroides fragilis

986751
987302

NZ_UFTH01000001.1

Bacteroides fragilis

3476837
3476280

NZ_UFTH01000001.1

Bacteroides fragilis

4140659
4140123

NZ_UFTH01000001.1

Bacteroides fragilis

619273
618815

BACDOR_03934

1
383

CVOZ01000011.1

Bacteroides thetaiotaomicron

219307
218162

CVOZ01000025.1

Bacteroides thetaiotaomicron

65950
64922

JGCP01000352.1

Bacteroides fragilis

1001
3

JGCP01002360.1

Bacteroides fragilis

22362
21214

NC_009614.1

Bacteroides vulgatus

3184401
3185549

NC_009615.1

Parabacteroides distasonis

4010282
4011415

NC_010655.1

Akkermansia muciniphila

2181548
2180451

NC_010655.1

Akkermansia muciniphila

910779
911906

NZ_AAVM02000006.1

Bacteroides caccae

286955
285927

NZ_AAVM02000010.1

Bacteroides caccae

85750
86895

NZ_ABJL02000007.1

Bacteroides intestinalis

1352596
1353708

NZ_ABJL02000008.1

Bacteroides intestinalis

11440
12579

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

320605
319457

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

433197
432070

NZ_ATFI01000007.1

Bacteroides cellulosilyticus

180818
179655

NZ_CVOY01000001.1

Bacteroides thetaiotaomicron

78559
77414

NZ_CVOY01000013.1

Bacteroides thetaiotaomicron

61412
60384

NZ_DS264546.1

Parabacteroides merdae

79514
80632

NZ_DS264553.1

Bacteroides ovatus

176886
178034

NZ_DS264583.1

Bacteroides ovatus

172705
173733

NZ_DS362220.1

Bacteroides uniformis

32930
34078

NZ_DS362243.1

Bacteroides uniformis

130985
132106

NZ_DS499676.1

Bacteroides stercoris

625044
623935

NZ_DS499676.1

Bacteroides stercoris

38390
37269

NZ_DS995510.1

Bacteroides eggerthii

1115618
1114497

NZ_DS995537.1

Bacteroides dorei

622799
623947

NZ_DS995538.1

Bacteroides dorei

80104
79073

NZ_DS996453.1

Parabacteroides johnsonii

228018
229163

NZ_DS996453.1

Parabacteroides johnsonii

441885
442970

NZ_EQ973492.1

Bacteroides cellulosilyticus

841963
840815

NZ_EQ973492.1

Bacteroides cellulosilyticus

701350
700187

NZ_EQ973543.1

Bacteroides cellulosilyticus

698
3

NZ_EQ973643.1

Bacteroides coprophilus

523657
524796

NZ_GG688326.1

Bacteroides finegoldii

160819
161967

NZ_JH370372.1

Alistipes indistinctus

793551
792436

NZ_JH724294.1

Bacteroides xylanisolvens

2266288
2265140

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

85095
83950

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3708432
3709460

NZ_PUEP01000005.1

Bacteroides ovatus

1142186
1143334

NZ_PUEP01000005.1

Bacteroides ovatus

332061
331033

NZ_PUEQ01000002.1

Bacteroides caccae

334014
332986

NZ_PUEQ01000003.1

Bacteroides caccae

2119148
2118003

NZ_UFTH01000001.1

Bacteroides fragilis

2311470
2310322

BACDOR_03379

1
283

BT_4075

177
231

BT_4096

6
227

COLAER_00815

98
240

CVOZ01000004.1

Bacteroides thetaiotaomicron

1448
2302

CVOZ01000011.1

Bacteroides thetaiotaomicron

76210
77025

JGCP01002268.1

Bacteroides fragilis

1309
668

NC_009614.1

Bacteroides vulgatus

2618474
2619322

NZ_AAVM02000002.1

Bacteroides caccae

22009
21158

NZ_CVOY01000037.1

Bacteroides thetaiotaomicron

89304
90158

NZ_DS264554.1

Bacteroides ovatus

556147
555293

NZ_DS995537.1

Bacteroides dorei

24054
24902

NZ_DS996456.1

Parabacteroides johnsonii

449191
448439

NZ_JH724295.1

Bacteroides xylanisolvens

331849
330995

NZ_JH724300.1

Bacteroides xylanisolvens

14748
13909

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

699564
698710

NZ_PUEP01000005.1

Bacteroides ovatus

5040181
5041035

NZ_PUEQ01000003.1

Bacteroides caccae

3599902
3600753

BT_1192

73
143

CVOZ01000002.1

Bacteroides thetaiotaomicron

8661
7258

JGCP01000335.1

Bacteroides fragilis

8259
9164

JGCP01001024.1

Bacteroides fragilis

1280
3

JGCP01001257.1

Bacteroides fragilis

120
1442

JGCP01002379.1

Bacteroides fragilis

49119
48214

NC_009614.1

Bacteroides vulgatus

2668633
2669520

NC_009615.1

Parabacteroides distasonis

249678
250460

NZ_AAVM02000002.1

Bacteroides caccae

123305
124627

NZ_ABJL02000008.1

Bacteroides intestinalis

1704766
1706073

NZ_ABJL02000008.1

Bacteroides intestinalis

2748789
2747893

NZ_ACCL02000002.1

Marvinbryantia formatexigens

191124
192041

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

85812
84916

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

36384
35062

NZ_DS264579.1

Bacteroides ovatus

280554
281876

NZ_DS362220.1

Bacteroides uniformis

135151
134237

NZ_DS499676.1

Bacteroides stercoris

263901
264647

NZ_DS995508.1

Bacteroides eggerthii

458353
457493

NZ_DS995537.1

Bacteroides dorei

83077
83964

NZ_DS996455.1

Parabacteroides johnsonii

32570
31281

NZ_DS996841.1

Holdemanella biformis

28041
27679

NZ_EQ973491.1

Bacteroides cellulosilyticus

494795
495691

NZ_EQ973651.1

Bacteroides coprophilus

164919
166163

NZ_GG657587.1

Clostridium asparagiforme

221025
221390

NZ_GG692736.1

Roseburia intestinalis

18048
17698

NZ_JGDE01000029.1

Bacteroides fragilis

59138
58233

NZ_JH370371.1

Alistipes indistinctus

1369167
1369943

NZ_JH370371.1

Alistipes indistinctus

1341685
1342116

NZ_JH724295.1

Bacteroides xylanisolvens

574839
576158

NZ_JH724295.1

Bacteroides xylanisolvens

582861
584183

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

928679
930082

NZ_PUEP01000005.1

Bacteroides ovatus

4741344
4740022

NZ_PUEQ01000003.1

Bacteroides caccae

3498606
3497284

NZ_UFTH01000001.1

Bacteroides fragilis

2926029
2925124

BACDOR_03642

180
274

BT_4091

419
654

BT_4091

5
222

CVOZ01000011.1

Bacteroides thetaiotaomicron

74671
76059

CVOZ01000011.1

Bacteroides thetaiotaomicron

33113
34528

CVOZ01000021.1

Bacteroides thetaiotaomicron

107438
108184

CVOZ01000021.1

Bacteroides thetaiotaomicron

106535
107161

CVOZ01000033.1

Bacteroides thetaiotaomicron

69509
68802

CVOZ01000033.1

Bacteroides thetaiotaomicron

70706
70098

CVOZ01000041.1

Bacteroides thetaiotaomicron

304006
305376

CVOZ01000043.1

Bacteroides thetaiotaomicron

114574
116010

CVOZ01000043.1

Bacteroides thetaiotaomicron

64290
65657

CVOZ01000043.1

Bacteroides thetaiotaomicron

101489
102028

CVOZ01000043.1

Bacteroides thetaiotaomicron

102635
103321

CVOZ01000044.1

Bacteroides thetaiotaomicron

30432
31790

CVOZ01000044.1

Bacteroides thetaiotaomicron

11573
12922

CVOZ01000044.1

Bacteroides thetaiotaomicron

54744
56120

CVOZ01000045.1

Bacteroides thetaiotaomicron

113209
114579

JGCP01000263.1

Bacteroides fragilis

828
1

JGCP01000476.1

Bacteroides fragilis

1146
52

JGCP01001016.1

Bacteroides fragilis

5
166

JGCP01001396.1

Bacteroides fragilis

664
2091

JGCP01001637.1

Bacteroides fragilis

489
19

JGCP01001863.1

Bacteroides fragilis

2422
1022

JGCP01002441.1

Bacteroides fragilis

11079
12482

JGCP01002533.1

Bacteroides fragilis

3492
4082

JGCP01002533.1

Bacteroides fragilis

4677
5375

NC_008618.1

Bifidobacterium adolescentis

113104
114804

NC_008618.1

Bifidobacterium adolescentis

1901066
1902565

NC_008618.1

Bifidobacterium adolescentis

539816
540412

NC_008618.1

Bifidobacterium adolescentis

541031
541483

NC_009614.1

Bacteroides vulgatus

3437190
3438560

NC_009614.1

Bacteroides vulgatus

5099014
5097611

NC_009614.1

Bacteroides vulgatus

1019138
1018545

NC_009614.1

Bacteroides vulgatus

1017941
1017240

NC_009614.1

Bacteroides vulgatus

4737637
4738329

NC_009614.1

Bacteroides vulgatus

4736464
4737261

NC_009614.1

Bacteroides vulgatus

34966
34268

NC_009614.1

Bacteroides vulgatus

36130
35552

NC_009615.1

Parabacteroides distasonis

58665
57307

NC_009615.1

Parabacteroides distasonis

3530017
3531420

NC_010655.1

Akkermansia muciniphila

541896
543332

NZ_AAVM02000001.1

Bacteroides caccae

1239561
1238158

NZ_AAVM02000005.1

Bacteroides caccae

56513
57871

NZ_ABJL02000002.1

Bacteroides intestinalis

240119
238749

NZ_ABJL02000006.1

Bacteroides intestinalis

172382
172182

NZ_ABJL02000007.1

Bacteroides intestinalis

719924
721378

NZ_ABJL02000007.1

Bacteroides intestinalis

507938
508528

NZ_ABJL02000007.1

Bacteroides intestinalis

509108
509818

NZ_ABJL02000008.1

Bacteroides intestinalis

3173906
3175297

NZ_ABJL02000008.1

Bacteroides intestinalis

3169283
3167952

NZ_ABJL02000008.1

Bacteroides intestinalis

944085
945464

NZ_ABJL02000008.1

Bacteroides intestinalis

2525240
2524545

NZ_ABJL02000008.1

Bacteroides intestinalis

2526407
2525829

NZ_ABJL02000008.1

Bacteroides intestinalis

2484193
2484876

NZ_ABJL02000008.1

Bacteroides intestinalis

2485399
2485773

NZ_ACCL02000028.1

Marvinbryantia formatexigens

17836
18624

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1754879
1755607

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

716683
715988

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

717868
717170

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

340148
339480

NZ_DS995537.1

Bacteroides dorei

622799
623947

NZ_DS995538.1

Bacteroides dorei

80104
79073

NZ_DS996453.1

Parabacteroides johnsonii

228018
229163

NZ_DS996453.1

Parabacteroides johnsonii

441885
442970

NZ_EQ973492.1

Bacteroides cellulosilyticus

841963
840815

NZ_EQ973492.1

Bacteroides cellulosilyticus

701350
700187

NZ_EQ973543.1

Bacteroides cellulosilyticus

698
3

NZ_EQ973643.1

Bacteroides coprophilus

523657
524796

NZ_GG688326.1

Bacteroides finegoldii

160819
161967

NZ_JH370372.1

Alistipes indistinctus

793551
792436

NZ_JH724294.1

Bacteroides xylanisolvens

2266288
2265140

NZ_PUEO01000011.1

Bacteroides thetaiotaomicron

85095
83950

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3708432
3709460

NZ_PUEP01000005.1

Bacteroides ovatus

1142186
1143334

NZ_PUEP01000005.1

Bacteroides ovatus

332061
331033

NZ_PUEQ01000002.1

Bacteroides caccae

334014
332986

NZ_PUEQ01000003.1

Bacteroides caccae

2119148
2118003

NZ_UFTH01000001.1

Bacteroides fragilis

2311470
2310322

BACDOR_03379

1
283

BT_4075

177
231

BT_4096

6
227

COLAER_00815

98
240

CVOZ01000004.1

Bacteroides thetaiotaomicron

1448
2302

CVOZ01000011.1

Bacteroides thetaiotaomicron

76210
77025

JGCP01002268.1

Bacteroides fragilis

1309
668

NC_009614.1

Bacteroides vulgatus

2618474
2619322

NZ_AAVM02000002.1

Bacteroides caccae

22009
21158

NZ_CVOY01000037.1

Bacteroides thetaiotaomicron

89304
90158

NZ_DS264554.1

Bacteroides ovatus

556147
555293

NZ_DS995537.1

Bacteroides dorei

24054
24902

NZ_DS996456.1

Parabacteroides johnsonii

449191
448439

NZ_JH724295.1

Bacteroides xylanisolvens

331849
330995

NZ_JH724300.1

Bacteroides xylanisolvens

14748
13909

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

699564
698710

NZ_PUEP01000005.1

Bacteroides ovatus

5040181
5041035

NZ_PUEQ01000003.1

Bacteroides caccae

3599902
3600753

BT_1192

73
143

CVOZ01000002.1

Bacteroides thetaiotaomicron

8661
7258

JGCP01000335.1

Bacteroides fragilis

8259
9164

JGCP01001024.1

Bacteroides fragilis

1280
3

JGCP01001257.1

Bacteroides fragilis

120
1442

JGCP01002379.1

Bacteroides fragilis

49119
48214

NC_009614.1

Bacteroides vulgatus

2668633
2669520

NC_009615.1

Parabacteroides distasonis

249678
250460

NZ_AAVM02000002.1

Bacteroides caccae

123305
124627

NZ_ABJL02000008.1

Bacteroides intestinalis

1704766
1706073

NZ_ABJL02000008.1

Bacteroides intestinalis

2748789
2747893

NZ_ACCL02000002.1

Marvinbryantia formatexigens

191124
192041

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

85812
84916

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

36384
35062

NZ_DS264579.1

Bacteroides ovatus

280554
281876

NZ_DS362220.1

Bacteroides uniformis

135151
134237

NZ_DS499676.1

Bacteroides stercoris

263901
264647

NZ_DS995508.1

Bacteroides eggerthii

458353
457493

NZ_DS995537.1

Bacteroides dorei

83077
83964

NZ_DS996455.1

Parabacteroides johnsonii

32570
31281

NZ_DS996841.1

Holdemanella biformis

28041
27679

NZ_EQ973491.1

Bacteroides cellulosilyticus

494795
495691

NZ_EQ973651.1

Bacteroides coprophilus

164919
166163

NZ_GG657587.1

Clostridium asparagiforme

221025
221390

NZ_GG692736.1

Roseburia intestinalis

18048
17698

NZ_JGDE01000029.1

Bacteroides fragilis

59138
58233

NZ_JH370371.1

Alistipes indistinctus

1369167
1369943

NZ_JH370371.1

Alistipes indistinctus

1341685
1342116

NZ_JH724295.1

Bacteroides xylanisolvens

574839
576158

NZ_JH724295.1

Bacteroides xylanisolvens

582861
584183

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

928679
930082

NZ_PUEP01000005.1

Bacteroides ovatus

4741344
4740022

NZ_PUEQ01000003.1

Bacteroides caccae

3498606
3497284

NZ_UFTH01000001.1

Bacteroides fragilis

2926029
2925124

BACDOR_03642

180
274

BT_4091

419
654

BT_4091

5
222

CVOZ01000011.1

Bacteroides thetaiotaomicron

74671
76059

CVOZ01000011.1

Bacteroides thetaiotaomicron

33113
34528

CVOZ01000021.1

Bacteroides thetaiotaomicron

107438
108184

CVOZ01000021.1

Bacteroides thetaiotaomicron

106535
107161

CVOZ01000033.1

Bacteroides thetaiotaomicron

69509
68802

CVOZ01000033.1

Bacteroides thetaiotaomicron

70706
70098

CVOZ01000041.1

Bacteroides thetaiotaomicron

304006
305376

CVOZ01000043.1

Bacteroides thetaiotaomicron

114574
116010

CVOZ01000043.1

Bacteroides thetaiotaomicron

64290
65657

CVOZ01000043.1

Bacteroides thetaiotaomicron

101489
102028

CVOZ01000043.1

Bacteroides thetaiotaomicron

102635
103321

CVOZ01000044.1

Bacteroides thetaiotaomicron

30432
31790

CVOZ01000044.1

Bacteroides thetaiotaomicron

11573
12922

CVOZ01000044.1

Bacteroides thetaiotaomicron

54744
56120

CVOZ01000045.1

Bacteroides thetaiotaomicron

113209
114579

JGCP01000263.1

Bacteroides fragilis

828
1

JGCP01000476.1

Bacteroides fragilis

1146
52

JGCP01001016.1

Bacteroides fragilis

5
166

JGCP01001396.1

Bacteroides fragilis

664
2091

JGCP01001637.1

Bacteroides fragilis

489
19

JGCP01001863.1

Bacteroides fragilis

2422
1022

JGCP01002441.1

Bacteroides fragilis

11079
12482

JGCP01002533.1

Bacteroides fragilis

3492
4082

JGCP01002533.1

Bacteroides fragilis

4677
5375

NC_008618.1

Bifidobacterium adolescentis

113104
114804

NC_008618.1

Bifidobacterium adolescentis

1901066
1902565

NC_008618.1

Bifidobacterium adolescentis

539816
540412

NC_008618.1

Bifidobacterium adolescentis

541031
541483

NC_009614.1

Bacteroides vulgatus

3437190
3438560

NC_009614.1

Bacteroides vulgatus

5099014
5097611

NC_009614.1

Bacteroides vulgatus

1019138
1018545

NC_009614.1

Bacteroides vulgatus

1017941
1017240

NC_009614.1

Bacteroides vulgatus

4737637
4738329

NC_009614.1

Bacteroides vulgatus

4736464
4737261

NC_009614.1

Bacteroides vulgatus

34966
34268

NC_009614.1

Bacteroides vulgatus

36130
35552

NC_009615.1

Parabacteroides distasonis

58665
57307

NC_009615.1

Parabacteroides distasonis

3530017
3531420

NC_010655.1

Akkermansia muciniphila

541896
543332

NZ_AAVM02000001.1

Bacteroides caccae

1239561
1238158

NZ_AAVM02000005.1

Bacteroides caccae

56513
57871

NZ_ABJL02000002.1

Bacteroides intestinalis

240119
238749

NZ_ABJL02000006.1

Bacteroides intestinalis

172382
172182

NZ_ABJL02000007.1

Bacteroides intestinalis

719924
721378

NZ_ABJL02000007.1

Bacteroides intestinalis

507938
508528

NZ_ABJL02000007.1

Bacteroides intestinalis

509108
509818

NZ_ABJL02000008.1

Bacteroides intestinalis

3173906
3175297

NZ_ABJL02000008.1

Bacteroides intestinalis

3169283
3167952

NZ_ABJL02000008.1

Bacteroides intestinalis

944085
945464

NZ_ABJL02000008.1

Bacteroides intestinalis

2525240
2524545

NZ_ABJL02000008.1

Bacteroides intestinalis

2526407
2525829

NZ_ABJL02000008.1

Bacteroides intestinalis

2484193
2484876

NZ_ABJL02000008.1

Bacteroides intestinalis

2485399
2485773

NZ_ACCL02000028.1

Marvinbryantia formatexigens

17836
18624

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1754879
1755607

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

716683
715988

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

717868
717170

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

340148
339480

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1753760
1754329

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

341297
340749

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

667727
669118

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

665971
664640

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

634679
636016

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

636101
637438

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

748203
746851

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

344620
343925

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

345787
345209

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

291205
291885

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

292408
292782

NZ_ATFI01000010.1

Bacteroides cellulosilyticus

116498
115128

NZ_ATFI01000013.1

Bacteroides cellulosilyticus

166257
164884

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

2896
3603

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

1699
2307

NZ_CVOY01000015.1

Bacteroides thetaiotaomicron

29835
31205

NZ_CVOY01000028.1

Bacteroides thetaiotaomicron

92641
94011

NZ_CVOY01000029.1

Bacteroides thetaiotaomicron

122519
123865

NZ_CVOY01000041.1

Bacteroides thetaiotaomicron

66500
65124

NZ_CVOY01000043.1

Bacteroides thetaiotaomicron

51552
52919

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

19916
21352

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

6767
7363

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

7970
8656

NZ_CVOY01000089.1

Bacteroides thetaiotaomicron

11279
12025

NZ_CVOY01000089.1

Bacteroides thetaiotaomicron

10376
11002

NZ_CVOY01000094.1

Bacteroides thetaiotaomicron

1
846

NZ_CVOY01000102.1

Bacteroides thetaiotaomicron

4048
2699

NZ_CVOY01000120.1

Bacteroides thetaiotaomicron

2031
2558

NZ_DS264461.1

Parabacteroides merdae

326679
328088

NZ_DS264553.1

Bacteroides ovatus

485184
483814

NZ_DS264563.1

Bacteroides ovatus

240601
239249

NZ_DS264563.1

Bacteroides ovatus

230088
231446

NZ_DS264579.1

Bacteroides ovatus

190274
188934

NZ_DS264579.1

Bacteroides ovatus

345939
344572

NZ_DS264579.1

Bacteroides ovatus

26411
27115

NZ_DS264579.1

Bacteroides ovatus

25214
25867

NZ_DS264581.1

Bacteroides ovatus

193952
193377

NZ_DS264581.1

Bacteroides ovatus

192791
192096

NZ_DS264583.1

Bacteroides ovatus

293997
293422

NZ_DS264583.1

Bacteroides ovatus

292812
292450

NZ_DS264584.1

Bacteroides ovatus

458625
459983

NZ_DS362248.1

Bacteroides uniformis

463612
462248

NZ_DS362248.1

Bacteroides uniformis

44198
45535

NZ_DS499654.1

Erysipelatoclostridium ramosum

458831
460294

NZ_DS499669.1

Bacteroides stercoris

56028
54667

NZ_DS499673.1

Bacteroides stercoris

494276
495676

NZ_DS995509.1

Bacteroides eggerthii

43221
44582

NZ_DS995509.1

Bacteroides eggerthii

775569
776297

NZ_DS995509.1

Bacteroides eggerthii

772156
771578

NZ_DS995509.1

Bacteroides eggerthii

774495
775103

NZ_DS995509.1

Bacteroides eggerthii

770989
770606

NZ_DS995510.1

Bacteroides eggerthii

502400
501018

NZ_DS995510.1

Bacteroides eggerthii

528488
529825

NZ_DS995510.1

Bacteroides eggerthii

204435
205853

NZ_DS995511.1

Bacteroides eggerthii

320527
319190

NZ_DS995511.1

Bacteroides eggerthii

378660
377212

NZ_DS995511.1

Bacteroides eggerthii

445669
444224

NZ_DS995531.1

Bacteroides dorei

371558
372925

NZ_DS995531.1

Bacteroides dorei

449132
450535

NZ_DS995531.1

Bacteroides dorei

312254
312832

NZ_DS995531.1

Bacteroides dorei

313421
314116

NZ_DS995533.1

Bacteroides dorei

1775
1083

NZ_DS995533.1

Bacteroides dorei

2948
2379

NZ_DS995537.1

Bacteroides dorei

920220
921590

NZ_DS995538.1

Bacteroides dorei

45726
45025

NZ_DS995538.1

Bacteroides dorei

46932
46330

NZ_DS996444.1

Parabacteroides johnsonii

535363
536772

NZ_DS996444.1

Parabacteroides johnsonii

269736
269134

NZ_DS996444.1

Parabacteroides johnsonii

268632
268198

NZ_EQ973486.1

Bacteroides cellulosilyticus

124072
122681

NZ_EQ973486.1

Bacteroides cellulosilyticus

126082
127413

NZ_EQ973486.1

Bacteroides cellulosilyticus

157708
156371

NZ_EQ973486.1

Bacteroides cellulosilyticus

156286
154949

NZ_EQ973486.1

Bacteroides cellulosilyticus

42916
44025

NZ_EQ973486.1

Bacteroides cellulosilyticus

43994
44269

NZ_EQ973490.1

Bacteroides cellulosilyticus

50726
49353

NZ_EQ973490.1

Bacteroides cellulosilyticus

1964751
1965479

NZ_EQ973490.1

Bacteroides cellulosilyticus

811729
811031

NZ_EQ973490.1

Bacteroides cellulosilyticus

445831
445163

NZ_EQ973490.1

Bacteroides cellulosilyticus

810544
810017

NZ_EQ973490.1

Bacteroides cellulosilyticus

1963632
1964201

NZ_EQ973490.1

Bacteroides cellulosilyticus

446980
446432

NZ_EQ973491.1

Bacteroides cellulosilyticus

107522
108793

NZ_EQ973491.1

Bacteroides cellulosilyticus

756794
757489

NZ_EQ973491.1

Bacteroides cellulosilyticus

755627
756205

NZ_EQ973491.1

Bacteroides cellulosilyticus

811215
810535

NZ_EQ973491.1

Bacteroides cellulosilyticus

810012
809638

NZ_EQ973495.1

Bacteroides cellulosilyticus

70783
72162

NZ_EQ973645.1

Bacteroides coprophilus

64693
66096

NZ_GG667711.1

Hungatella hathewayi

24610
23903

NZ_GG667711.1

Hungatella hathewayi

25807
25196

NZ_GG688320.1

Bacteroides finegoldii

174406
173048

NZ_GG688323.1

Bacteroides finegoldii

51406
50036

NZ_GG688332.1

Bacteroides finegoldii

82694
82395

NZ_GG703863.1

Prevotella copri

25172
26572

NZ_JGDE01000072.1

Bacteroides fragilis

10558
11961

NZ_JGDE01000126.1

Bacteroides fragilis

27194
27784

NZ_JGDE01000126.1

Bacteroides fragilis

28379
29077

NZ_JH724294.1

Bacteroides xylanisolvens

1911484
1912854

NZ_JH724294.1

Bacteroides xylanisolvens

1590639
1589281

NZ_JH724294.1

Bacteroides xylanisolvens

361730
362440

NZ_JH724294.1

Bacteroides xylanisolvens

360536
361126

NZ_JH724295.1

Bacteroides xylanisolvens

1623208
1624584

NZ_JH724295.1

Bacteroides xylanisolvens

661738
660371

NZ_JH724296.1

Bacteroides xylanisolvens

499153
497783

NZ_JH724296.1

Bacteroides xylanisolvens

239797
241236

NZ_JH724298.1

Bacteroides xylanisolvens

184281
184970

NZ_JH724298.1

Bacteroides xylanisolvens

185469
185849

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

951107
949671

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

1015372
1014005

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

964257
963661

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

963054
962368

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2339682
2341040

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3014588
3013218

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

184534
183164

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2364015
2365391

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

868998
869705

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

4023284
4022538

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

867801
868409

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

4024187
4023561

NZ_PUEP01000005.1

Bacteroides ovatus

4831625
4832965

NZ_PUEP01000005.1

Bacteroides ovatus

1909400
1910752

NZ_PUEP01000005.1

Bacteroides ovatus

1450439
1449069

NZ_PUEP01000005.1

Bacteroides ovatus

1919913
1918555

NZ_PUEP01000005.1

Bacteroides ovatus

4675959
4677326

NZ_PUEP01000005.1

Bacteroides ovatus

2987124
2985766

NZ_PUEP01000005.1

Bacteroides ovatus

4995491
4994787

NZ_PUEP01000005.1

Bacteroides ovatus

4996688
4996035

NZ_PUEP01000005.1

Bacteroides ovatus

210770
211345

NZ_PUEP01000005.1

Bacteroides ovatus

3955317
3955892

NZ_PUEP01000005.1

Bacteroides ovatus

3956478
3957173

NZ_PUEP01000005.1

Bacteroides ovatus

211955
212317

NZ_PUEQ01000002.1

Bacteroides caccae

423398
424756

NZ_PUEQ01000003.1

Bacteroides caccae

1528370
1526967

NZ_UFTH01000001.1

Bacteroides fragilis

4051853
4053256

NZ_UFTH01000001.1

Bacteroides fragilis

634929
635519

NZ_UFTH01000001.1

Bacteroides fragilis

636114
636812

QEKH01000001.1

Victivallis vadensis

296578
297354

QEKH01000001.1

Victivallis vadensis

259902
259210

QEKH01000001.1

Victivallis vadensis

295345
295962

QEKH01000001.1

Victivallis vadensis

261147
260575

QEKH01000003.1

Victivallis vadensis

120748
122115

QEKH01000011.1

Victivallis vadensis

39979
38537

QEKH01000018.1

Victivallis vadensis

24528
23029

QEKH01000033.1

Victivallis vadensis

47019
45649

QEKH01000042.1

Victivallis vadensis

3416
4150

QEKH01000042.1

Victivallis vadensis

2183
2791

BACDOR_00665

45
104

BACDOR_03379

212
273

BT_0569

40
231

BT_2961

214
271

BT_4096

3
460

CVOZ01000033.1

Bacteroides thetaiotaomicron

99605
98205

CVOZ01000033.1

Bacteroides thetaiotaomicron

61396
60014

NC_009615.1

Parabacteroides distasonis

264706
266067

NC_009615.1

Parabacteroides distasonis

3795050
3796402

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

11010
12392

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

27423
26023

NZ_DS264584.1

Bacteroides ovatus

251782
253182

NZ_DS264584.1

Bacteroides ovatus

279314
280687

NZ_JH724294.1

Bacteroides xylanisolvens

336113
337513

NZ_JH724294.1

Bacteroides xylanisolvens

368251
369624

NZ_JH724294.1

Bacteroides xylanisolvens

357519
358895

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

838901
840301

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

877110
878492

NZ_PUEP01000005.1

Bacteroides ovatus

3193968
3192568

NZ_PUEP01000005.1

Bacteroides ovatus

3166436
3165063

QEKH01000001.1

Victivallis vadensis

132621
131368

QEKH01000002.1

Victivallis vadensis

100395
99751

QEKH01000021.1

Victivallis vadensis

86373
87041

QEKH01000042.1

Victivallis vadensis

14734
15321

BT_3124

241
479

BT_3124

3
228

CVOZ01000011.1

Bacteroides thetaiotaomicron

74620
75276

CVOZ01000011.1

Bacteroides thetaiotaomicron

33827
34531

CVOZ01000011.1

Bacteroides thetaiotaomicron

75238
76062

CVOZ01000011.1

Bacteroides thetaiotaomicron

33134
33793

CVOZ01000021.1

Bacteroides thetaiotaomicron

107432
108184

CVOZ01000021.1

Bacteroides thetaiotaomicron

106475
107299

CVOZ01000033.1

Bacteroides thetaiotaomicron

70763
68778

CVOZ01000041.1

Bacteroides thetaiotaomicron

303958
304608

CVOZ01000041.1

Bacteroides thetaiotaomicron

304672
305376

CVOZ01000043.1

Bacteroides thetaiotaomicron

101498
103327

CVOZ01000043.1

Bacteroides thetaiotaomicron

115294
116010

CVOZ01000043.1

Bacteroides thetaiotaomicron

64239
64898

CVOZ01000043.1

Bacteroides thetaiotaomicron

114580
115257

CVOZ01000043.1

Bacteroides thetaiotaomicron

64962
65666

CVOZ01000044.1

Bacteroides thetaiotaomicron

11540
12187

CVOZ01000044.1

Bacteroides thetaiotaomicron

30408
31103

CVOZ01000044.1

Bacteroides thetaiotaomicron

31080
31790

CVOZ01000044.1

Bacteroides thetaiotaomicron

55437
56120

CVOZ01000044.1

Bacteroides thetaiotaomicron

12212
12922

CVOZ01000044.1

Bacteroides thetaiotaomicron

54720
55550

CVOZ01000045.1

Bacteroides thetaiotaomicron

113179
113826

CVOZ01000045.1

Bacteroides thetaiotaomicron

113845
114579

JGCP01000263.1

Bacteroides fragilis

858
211

JGCP01000263.1

Bacteroides fragilis

171
1

JGCP01000476.1

Bacteroides fragilis

900
43

JGCP01000476.1

Bacteroides fragilis

1149
802

JGCP01001016.1

Bacteroides fragilis

8
328

JGCP01001396.1

Bacteroides fragilis

1381
2091

JGCP01001396.1

Bacteroides fragilis

664
1266

JGCP01001637.1

Bacteroides fragilis

489
7

JGCP01001863.1

Bacteroides fragilis

1705
1019

JGCP01001863.1

Bacteroides fragilis

2422
1820

JGCP01002441.1

Bacteroides fragilis

11796
12482

JGCP01002441.1

Bacteroides fragilis

11079
11681

JGCP01002533.1

Bacteroides fragilis

3435
5387

NC_008618.1

Bifidobacterium adolescentis

539801
541717

NC_008618.1

Bifidobacterium adolescentis

113920
114804

NC_008618.1

Bifidobacterium adolescentis

113092
114030

NC_008618.1

Bifidobacterium adolescentis

393068
393487

NC_008618.1

Bifidobacterium adolescentis

1901057
1901710

NC_009614.1

Bacteroides vulgatus

1019192
1017240

NC_009614.1

Bacteroides vulgatus

4736413
4738329

NC_009614.1

Bacteroides vulgatus

36139
34268

NC_009614.1

Bacteroides vulgatus

3437145
3437807

NC_009614.1

Bacteroides vulgatus

5098297
5097611

NC_009614.1

Bacteroides vulgatus

3437826
3438560

NC_009614.1

Bacteroides vulgatus

5099014
5098412

NC_009615.1

Parabacteroides distasonis

3530692
3531420

NC_009615.1

Parabacteroides distasonis

58080
57307

NC_009615.1

Parabacteroides distasonis

58722
58066

NC_009615.1

Parabacteroides distasonis

3530017
3530631

NC_010655.1

Akkermansia muciniphila

542610
543332

NC_010655.1

Akkermansia muciniphila

541896
542486

NZ_AAVM02000001.1

Bacteroides caccae

1238844
1238158

NZ_AAVM02000001.1

Bacteroides caccae

1239561
1238959

NZ_AAVM02000005.1

Bacteroides caccae

57149
57871

NZ_AAVM02000005.1

Bacteroides caccae

56462
57106

NZ_ABJL02000002.1

Bacteroides intestinalis

239465
238749

NZ_ABJL02000002.1

Bacteroides intestinalis

240158
239496

NZ_ABJL02000006.1

Bacteroides intestinalis

172436
172182

NZ_ABJL02000007.1

Bacteroides intestinalis

507881
509830

NZ_ABJL02000007.1

Bacteroides intestinalis

720668
721381

NZ_ABJL02000007.1

Bacteroides intestinalis

719873
720490

NZ_ABJL02000008.1

Bacteroides intestinalis

2526443
2524545

NZ_ABJL02000008.1

Bacteroides intestinalis

2484163
2485770

NZ_ABJL02000008.1

Bacteroides intestinalis

944772
945464

NZ_ABJL02000008.1

Bacteroides intestinalis

3168665
3167952

NZ_ABJL02000008.1

Bacteroides intestinalis

3174590
3175297

NZ_ABJL02000008.1

Bacteroides intestinalis

3169325
3168690

NZ_ABJL02000008.1

Bacteroides intestinalis

944064
944690

NZ_ABJL02000008.1

Bacteroides intestinalis

3173903
3174544

NZ_ACCL02000028.1

Marvinbryantia formatexigens

16369
18624

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

717919
715976

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1753709
1755610

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

341321
339480

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

176816
176448

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

665353
664640

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

634622
635347

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

666022
665381

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

635333
636016

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

636062
636697

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

747630
746851

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

668414
669118

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

667739
668365

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

748281
747637

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

636749
637447

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

345823
343925

NZ_ATFI01000009.1

Bacteroides cellulosilyticus

291172
292779

NZ_ATFI01000010.1

Bacteroides cellulosilyticus

116525
115881

NZ_ATFI01000010.1

Bacteroides cellulosilyticus

115862
115128

NZ_ATFI01000013.1

Bacteroides cellulosilyticus

165564
164869

NZ_ATFI01000013.1

Bacteroides cellulosilyticus

166287
165634

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

1642
3627

NZ_CVOY01000015.1

Bacteroides thetaiotaomicron

29805
30452

NZ_CVOY01000015.1

Bacteroides thetaiotaomicron

30471
31205

NZ_CVOY01000028.1

Bacteroides thetaiotaomicron

92593
93243

NZ_CVOY01000028.1

Bacteroides thetaiotaomicron

93307
94011

NZ_CVOY01000029.1

Bacteroides thetaiotaomicron

122462
123130

NZ_CVOY01000029.1

Bacteroides thetaiotaomicron

123170
123865

NZ_CVOY01000041.1

Bacteroides thetaiotaomicron

65807
65124

NZ_CVOY01000041.1

Bacteroides thetaiotaomicron

66524
65694

NZ_CVOY01000043.1

Bacteroides thetaiotaomicron

51501
52160

NZ_CVOY01000043.1

Bacteroides thetaiotaomicron

52224
52928

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

6722
8662

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

20636
21352

NZ_CVOY01000050.1

Bacteroides thetaiotaomicron

19922
20599

NZ_CVOY01000089.1

Bacteroides thetaiotaomicron

11273
12025

NZ_CVOY01000089.1

Bacteroides thetaiotaomicron

10316
11140

NZ_CVOY01000094.1

Bacteroides thetaiotaomicron

136
846

NZ_CVOY01000102.1

Bacteroides thetaiotaomicron

4081
3434

NZ_CVOY01000102.1

Bacteroides thetaiotaomicron

3409
2699

NZ_CVOY01000120.1

Bacteroides thetaiotaomicron

2007
2552

NZ_DS264461.1

Parabacteroides merdae

327354
328088

NZ_DS264461.1

Parabacteroides merdae

326694
327290

NZ_DS264553.1

Bacteroides ovatus

485214
484567

NZ_DS264553.1

Bacteroides ovatus

484548
483814

NZ_DS264563.1

Bacteroides ovatus

230064
230708

NZ_DS264563.1

Bacteroides ovatus

240646
239993

NZ_DS264563.1

Bacteroides ovatus

240010
239249

NZ_DS264563.1

Bacteroides ovatus

230733
231446

NZ_DS264579.1

Bacteroides ovatus

25214
27115

NZ_DS264579.1

Bacteroides ovatus

189683
188934

NZ_DS264579.1

Bacteroides ovatus

345420
344563

NZ_DS264579.1

Bacteroides ovatus

190319
189654

NZ_DS264579.1

Bacteroides ovatus

345930
345322

NZ_DS264581.1

Bacteroides ovatus

194006
192096

NZ_DS264583.1

Bacteroides ovatus

294027
292444

NZ_DS264584.1

Bacteroides ovatus

459309
460004

NZ_DS264584.1

Bacteroides ovatus

458592
459305

NZ_DS264584.1

Bacteroides ovatus

273310
273522

NZ_DS362248.1

Bacteroides uniformis

463033
462248

NZ_DS362248.1

Bacteroides uniformis

463663
463004

NZ_DS362248.1

Bacteroides uniformis

44192
44803

NZ_DS362248.1

Bacteroides uniformis

44831
45532

NZ_DS499654.1

Erysipelatoclostridium ramosum

459551
460294

NZ_DS499654.1

Erysipelatoclostridium ramosum

458840
459829

NZ_DS499669.1

Bacteroides stercoris

55347
54652

NZ_DS499669.1

Bacteroides stercoris

56085
55366

NZ_DS499673.1

Bacteroides stercoris

494828
495712

NZ_DS499673.1

Bacteroides stercoris

494264
494887

NZ_DS995509.1

Bacteroides eggerthii

774444
776297

NZ_DS995509.1

Bacteroides eggerthii

772192
770606

NZ_DS995509.1

Bacteroides eggerthii

43167
43862

NZ_DS995509.1

Bacteroides eggerthii

43842
44582

NZ_DS995510.1

Bacteroides eggerthii

529121
529825

NZ_DS995510.1

Bacteroides eggerthii

501722
501018

NZ_DS995510.1

Bacteroides eggerthii

528449
529084

NZ_DS995510.1

Bacteroides eggerthii

502442
501771

NZ_DS995510.1

Bacteroides eggerthii

205068
205853

NZ_DS995510.1

Bacteroides eggerthii

204429
205115

NZ_DS995511.1

Bacteroides eggerthii

377907
377200

NZ_DS995511.1

Bacteroides eggerthii

444934
444194

NZ_DS995511.1

Bacteroides eggerthii

320605
319916

NZ_DS995511.1

Bacteroides eggerthii

319891
319190

NZ_DS995511.1

Bacteroides eggerthii

445651
445079

NZ_DS995511.1

Bacteroides eggerthii

378660
378064

NZ_DS995531.1

Bacteroides dorei

312233
314116

NZ_DS995531.1

Bacteroides dorei

449795
450535

NZ_DS995531.1

Bacteroides dorei

372209
372925

NZ_DS995531.1

Bacteroides dorei

371504
372148

NZ_DS995531.1

Bacteroides dorei

449132
449734

NZ_DS995533.1

Bacteroides dorei

2999
1083

NZ_DS995537.1

Bacteroides dorei

920175
920837

NZ_DS995537.1

Bacteroides dorei

920856
921590

NZ_DS995538.1

Bacteroides dorei

46977
45025

NZ_DS996444.1

Parabacteroides johnsonii

269793
268207

NZ_DS996444.1

Parabacteroides johnsonii

536038
536772

NZ_DS996444.1

Parabacteroides johnsonii

535381
535974

NZ_EQ973486.1

Bacteroides cellulosilyticus

126700
127413

NZ_EQ973486.1

Bacteroides cellulosilyticus

157765
157040

NZ_EQ973486.1

Bacteroides cellulosilyticus

157054
156371

NZ_EQ973486.1

Bacteroides cellulosilyticus

156325
155690

NZ_EQ973486.1

Bacteroides cellulosilyticus

126031
126672

NZ_EQ973486.1

Bacteroides cellulosilyticus

123385
122681

NZ_EQ973486.1

Bacteroides cellulosilyticus

43489
43956

NZ_EQ973486.1

Bacteroides cellulosilyticus

43994
44269

NZ_EQ973486.1

Bacteroides cellulosilyticus

124060
123434

NZ_EQ973486.1

Bacteroides cellulosilyticus

42838
43482

NZ_EQ973486.1

Bacteroides cellulosilyticus

155638
154940

NZ_EQ973490.1

Bacteroides cellulosilyticus

811780
810014

NZ_EQ973490.1

Bacteroides cellulosilyticus

1963581
1965482

NZ_EQ973490.1

Bacteroides cellulosilyticus

447004
445163

NZ_EQ973490.1

Bacteroides cellulosilyticus

50033
49338

NZ_EQ973490.1

Bacteroides cellulosilyticus

50756
50103

NZ_EQ973490.1

Bacteroides cellulosilyticus

791221
791045

NZ_EQ973490.1

Bacteroides cellulosilyticus

276595
276227

NZ_EQ973491.1

Bacteroides cellulosilyticus

755591
757489

NZ_EQ973491.1

Bacteroides cellulosilyticus

811248
809641

NZ_EQ973491.1

Bacteroides cellulosilyticus

107495
108139

NZ_EQ973491.1

Bacteroides cellulosilyticus

108158
108793

NZ_EQ973495.1

Bacteroides cellulosilyticus

71470
72162

NZ_EQ973495.1

Bacteroides cellulosilyticus

70762
71388

NZ_EQ973645.1

Bacteroides coprophilus

65398
66096

NZ_EQ973645.1

Bacteroides coprophilus

64693
65487

NZ_GG667711.1

Hungatella hathewayi

25792
23903

NZ_GG688320.1

Bacteroides finegoldii

173722
173027

NZ_GG688320.1

Bacteroides finegoldii

174439
173726

NZ_GG688323.1

Bacteroides finegoldii

51433
50789

NZ_GG688323.1

Bacteroides finegoldii

50770
50036

NZ_GG703863.1

Prevotella copri

25121
25768

NZ_GG703863.1

Prevotella copri

25823
26572

NZ_JGDE01000072.1

Bacteroides fragilis

11275
11961

NZ_JGDE01000072.1

Bacteroides fragilis

10558
11160

NZ_JGDE01000126.1

Bacteroides fragilis

27137
29089

NZ_JH724294.1

Bacteroides xylanisolvens

360479
362464

NZ_JH724294.1

Bacteroides xylanisolvens

1911454
1912101

NZ_JH724294.1

Bacteroides xylanisolvens

1590663
1590019

NZ_JH724294.1

Bacteroides xylanisolvens

1912120
1912854

NZ_JH724294.1

Bacteroides xylanisolvens

1589994
1589281

NZ_JH724295.1

Bacteroides xylanisolvens

1623178
1623825

NZ_JH724295.1

Bacteroides xylanisolvens

661219
660362

NZ_JH724295.1

Bacteroides xylanisolvens

661729
661121

NZ_JH724295.1

Bacteroides xylanisolvens

1623793
1624593

NZ_JH724296.1

Bacteroides xylanisolvens

240529
241266

NZ_JH724296.1

Bacteroides xylanisolvens

499186
498554

NZ_JH724296.1

Bacteroides xylanisolvens

498484
497780

NZ_JH724296.1

Bacteroides xylanisolvens

239746
240348

NZ_JH724298.1

Bacteroides xylanisolvens

184254
185849

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

964302
962362

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

950387
949671

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

1015423
1014764

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

951101
950424

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

1014700
1013996

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

867744
869729

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

4023290
4022538

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3014618
3013971

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3013952
3013218

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2339658
2340353

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2340330
2341040

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

184582
183932

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2364708
2365391

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

183868
183164

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

4024199
4023423

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2363991
2364821

NZ_PUEP01000005.1

Bacteroides ovatus

4996688
4994787

NZ_PUEP01000005.1

Bacteroides ovatus

3955263
3957173

NZ_PUEP01000005.1

Bacteroides ovatus

210740
212323

NZ_PUEP01000005.1

Bacteroides ovatus

2986440
2985745

NZ_PUEP01000005.1

Bacteroides ovatus

1450469
1449822

NZ_PUEP01000005.1

Bacteroides ovatus

4832216
4832965

NZ_PUEP01000005.1

Bacteroides ovatus

1919937
1919293

NZ_PUEP01000005.1

Bacteroides ovatus

1909355
1910008

NZ_PUEP01000005.1

Bacteroides ovatus

1449803
1449069

NZ_PUEP01000005.1

Bacteroides ovatus

2987157
2986444

NZ_PUEP01000005.1

Bacteroides ovatus

1909991
1910752

NZ_PUEP01000005.1

Bacteroides ovatus

1919268
1918555

NZ_PUEP01000005.1

Bacteroides ovatus

4676478
4677335

NZ_PUEP01000005.1

Bacteroides ovatus

4831580
4832245

NZ_PUEP01000005.1

Bacteroides ovatus

4675968
4676576

NZ_PUEP01000005.1

Bacteroides ovatus

3172440
3172228

NZ_PUEQ01000002.1

Bacteroides caccae

424034
424756

NZ_PUEQ01000002.1

Bacteroides caccae

423347
423991

NZ_PUEQ01000003.1

Bacteroides caccae

1527653
1526967

NZ_PUEQ01000003.1

Bacteroides caccae

1528370
1527768

NZ_UFTH01000001.1

Bacteroides fragilis

634872
636824

NZ_UFTH01000001.1

Bacteroides fragilis

4052570
4053256

NZ_UFTH01000001.1

Bacteroides fragilis

4051853
4052455

QEKH01000001.1

Victivallis vadensis

261147
259213

QEKH01000001.1

Victivallis vadensis

295375
297354

QEKH01000001.1

Victivallis vadensis

174465
174815

QEKH01000003.1

Victivallis vadensis

121426
122112

QEKH01000003.1

Victivallis vadensis

120697
121353

QEKH01000005.1

Victivallis vadensis

102693
102322

QEKH01000011.1

Victivallis vadensis

39211
38537

QEKH01000011.1

Victivallis vadensis

39979
39317

QEKH01000017.1

Victivallis vadensis

5676
5230

QEKH01000018.1

Victivallis vadensis

24540
23800

QEKH01000018.1

Victivallis vadensis

23730
23017

QEKH01000026.1

Victivallis vadensis

59633
60028

QEKH01000033.1

Victivallis vadensis

46335
45649

QEKH01000033.1

Victivallis vadensis

47037
46432

QEKH01000042.1

Victivallis vadensis

2180
4150

BACDOR_00665

24
209

BT_0569

39
231

BT_1192

267
452

BT_2961

11
271

BT_4075

8
466

CVOZ01000033.1

Bacteroides thetaiotaomicron

61393
60014

CVOZ01000033.1

Bacteroides thetaiotaomicron

99584
98208

NC_009615.1

Parabacteroides distasonis

3795026
3796402

NC_009615.1

Parabacteroides distasonis

264697
266070

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

11013
12392

NZ_CVOY01000007.1

Bacteroides thetaiotaomicron

27402
26026

NZ_DS264584.1

Bacteroides ovatus

279308
280687

NZ_DS264584.1

Bacteroides ovatus

251803
253182

NZ_DS362240.1

Bacteroides uniformis

192340
193038

NZ_DS996453.1

Parabacteroides johnsonii

23050
22433

NZ_JH724294.1

Bacteroides xylanisolvens

368245
369624

NZ_JH724294.1

Bacteroides xylanisolvens

357525
358895

NZ_JH724294.1

Bacteroides xylanisolvens

336134
337513

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

877113
878492

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

838922
840298

NZ_PUEP01000005.1

Bacteroides ovatus

3166442
3165063

NZ_PUEP01000005.1

Bacteroides ovatus

3193947
3192568

QEKH01000001.1

Victivallis vadensis

132621
131698

QEKH01000001.1

Victivallis vadensis

111338
110643

QEKH01000042.1

Victivallis vadensis

14734
15336

BT_1192

274
391

NZ_AAVN02000001.1

Collinsella aerofaciens

309869
309213

NZ_ACCL02000001.1

Marvinbryantia formatexigens

196740
197378

NZ_ACEP01000075.1

Eubacterium hallii

1967
2593

NZ_DS480699.1

Clostridium bolteae

56611
57216

NZ_DS544183.1

Anaerotruncus colihominis

164934
165578

NZ_DS990202.1

Ruminococcus lactaris

95396
94794

NZ_DS996840.1

Holdemanella biformis

66548
65937

NZ_GG657592.1

Clostridium asparagiforme

526631
526026

NZ_GG662012.1

Coprococcus comes

180676
180056

NZ_GG667621.1

Hungatella hathewayi

56888
57523

NZ_GG692722.1

Roseburia intestinalis

63578
62997

NZ_PUEM01000006.1

Clostridium bolteae

96643
97248

CVOZ01000005.1

Bacteroides thetaiotaomicron

57756
58391

CVOZ01000006.1

Bacteroides thetaiotaomicron

30425
31405

CVOZ01000006.1

Bacteroides thetaiotaomicron

3549
4445

CVOZ01000032.1

Bacteroides thetaiotaomicron

285470
284589

CVOZ01000033.1

Bacteroides thetaiotaomicron

41117
40113

CVOZ01000045.1

Bacteroides thetaiotaomicron

65855
64761

JGCP01000292.1

Bacteroides fragilis

188
1129

JGCP01000923.1

Bacteroides fragilis

469
2

JGCP01001315.1

Bacteroides fragilis

1656
1096

JGCP01001936.1

Bacteroides fragilis

2158
2640

NC_009614.1

Bacteroides vulgatus

3354933
3356018

NC_009614.1

Bacteroides vulgatus

2447171
2446089

NC_009614.1

Bacteroides vulgatus

2316235
2317242

NC_009614.1

Bacteroides vulgatus

1754976
1755668

NC_009614.1

Bacteroides vulgatus

229513
228737

NZ_AAVM02000003.1

Bacteroides caccae

185072
186076

NZ_AAVN02000002.1

Collinsella aerofaciens

330089
328836

NZ_AAYG02000009.1

Ruminococcus gnavus

76928
78010

NZ_AAYG02000020.1

Ruminococcus gnavus

155246
154575

NZ_ABJL02000006.1

Bacteroides intestinalis

172076
171060

NZ_ABJL02000006.1

Bacteroides intestinalis

163000
161969

NZ_ABJL02000007.1

Bacteroides intestinalis

472617
473339

NZ_ABJL02000007.1

Bacteroides intestinalis

480076
480798

NZ_ABJL02000008.1

Bacteroides intestinalis

2829172
2828048

NZ_ABJL02000008.1

Bacteroides intestinalis

1177965
1176991

NZ_ABJL02000008.1

Bacteroides intestinalis

1188047
1187424

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

967512
968423

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

822055
822963

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

746022
745300

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

196151
195027

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

349394
350368

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

448433
449446

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

339279
339935

NZ_ATFI01000010.1

Bacteroides cellulosilyticus

52643
53737

NZ_ATFI01000013.1

Bacteroides cellulosilyticus

164808
163792

NZ_ATFI01000013.1

Bacteroides cellulosilyticus

152238
151207

NZ_ATFI01000018.1

Bacteroides cellulosilyticus

141668
142606

NZ_ATFI01000018.1

Bacteroides cellulosilyticus

132297
133130

NZ_CVOY01000002.1

Bacteroides thetaiotaomicron

3895
4776

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

31282
32286

NZ_CVOY01000033.1

Bacteroides thetaiotaomicron

54890
55870

NZ_CVOY01000047.1

Bacteroides thetaiotaomicron

51696
52331

NZ_CVOY01000055.1

Bacteroides thetaiotaomicron

60965
59871

NZ_DS264461.1

Parabacteroides merdae

153316
152396

NZ_DS264554.1

Bacteroides ovatus

520925
520290

NZ_DS264582.1

Bacteroides ovatus

485007
483871

NZ_DS264584.1

Bacteroides ovatus

299154
300158

NZ_DS264584.1

Bacteroides ovatus

459996
461081

NZ_DS264584.1

Bacteroides ovatus

422114
422995

NZ_DS480676.1

Clostridium bolteae

33135
34307

NZ_DS480689.1

Clostridium bolteae

189055
188054

NZ_DS480702.1

Clostridium bolteae

114722
114084

NZ_DS499669.1

Bacteroides stercoris

54603
53575

NZ_DS499669.1

Bacteroides stercoris

41098
40067

NZ_DS499676.1

Bacteroides stercoris

563727
562723

NZ_DS995509.1

Bacteroides eggerthii

324943
326016

NZ_DS995509.1

Bacteroides eggerthii

32959
31790

NZ_DS995531.1

Bacteroides dorei

131233
132258

NZ_DS995534.1

Bacteroides dorei

665227
665934

NZ_DS995536.1

Bacteroides dorei

158689
159771

NZ_DS995536.1

Bacteroides dorei

286827
285820

NZ_DS995537.1

Bacteroides dorei

839046
840131

NZ_DS996445.1

Parabacteroides johnsonii

309779
310801

NZ_DS996453.1

Parabacteroides johnsonii

946
44

NZ_DS996453.1

Parabacteroides johnsonii

541071
541673

NZ_DS996921.1

Bacteroides pectinophilus

1792409
1793536

NZ_DS996921.1

Bacteroides pectinophilus

1408311
1409351

NZ_EQ973488.1

Bacteroides cellulosilyticus

305101
305769

NZ_EQ973488.1

Bacteroides cellulosilyticus

318355
318765

NZ_EQ973489.1

Bacteroides cellulosilyticus

401883
400945

NZ_EQ973489.1

Bacteroides cellulosilyticus

411254
410421

NZ_EQ973490.1

Bacteroides cellulosilyticus

49277
48261

NZ_EQ973490.1

Bacteroides cellulosilyticus

1172225
1173136

NZ_EQ973490.1

Bacteroides cellulosilyticus

36535
35504

NZ_EQ973490.1

Bacteroides cellulosilyticus

840046
839324

NZ_EQ973491.1

Bacteroides cellulosilyticus

390345
391469

NZ_EQ973495.1

Bacteroides cellulosilyticus

334170
333598

NZ_EQ973495.1

Bacteroides cellulosilyticus

227993
226980

NZ_EQ973495.1

Bacteroides cellulosilyticus

344769
344113

NZ_GG657591.1

Clostridium asparagiforme

931520
932323

NZ_GG657591.1

Clostridium asparagiforme

935934
936779

NZ_GG657595.1

Clostridium asparagiforme

537115
538233

NZ_GG667607.1

Hungatella hathewayi

113320
112511

NZ_GG667617.1

Hungatella hathewayi

14231
14869

NZ_GG667628.1

Hungatella hathewayi

38593
38027

NZ_GG688320.1

Bacteroides finegoldii

267192
266188

NZ_GG688320.1

Bacteroides finegoldii

173035
171950

NZ_GG688323.1

Bacteroides finegoldii

83014
84108

NZ_GG692716.1

Roseburia intestinalis

72286
72888

NZ_GG692716.1

Roseburia intestinalis

71753
72295

NZ_GG703852.1

Prevotella copri

90990
89896

NZ_GG704863.1

Enterobacter cancerogenus

1562280
1561468

NZ_JH724294.1

Bacteroides xylanisolvens

1862842
1861706

NZ_JH724294.1

Bacteroides xylanisolvens

388065
389069

NZ_JH724295.1

Bacteroides xylanisolvens

302144
301509

NZ_JH724295.1

Bacteroides xylanisolvens

278743
278141

NZ_PUEL01000004.1

Ruminococcus gnavus

2996334
2997416

NZ_PUEL01000004.1

Ruminococcus gnavus

1640981
1640310

NZ_PUEM01000006.1

Clostridium bolteae

1701794
1700622

NZ_PUEM01000006.1

Clostridium bolteae

3657608
3658609

NZ_PUEM01000006.1

Clostridium bolteae

4021074
4021712

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3061847
3062941

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

897383
898387

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

1024402
1025283

NZ_PUEP01000005.1

Bacteroides ovatus

1564102
1565238

NZ_PUEP01000005.1

Bacteroides ovatus

3146595
3145591

NZ_PUEP01000005.1

Bacteroides ovatus

2985753
2984668

NZ_PUEP01000005.1

Bacteroides ovatus

5075403
5076038

NZ_PUEP01000005.1

Bacteroides ovatus

3023635
3022754

NZ_PUEP01000005.1

Bacteroides ovatus

5098803
5099405

NZ_PUEQ01000003.1

Bacteroides caccae

2519904
2518900

BACDOR_03379

104
279

BACDOR_03642

343
492

BT_0445

202
292

BT_2961

108
281

CVOZ01000011.1

Bacteroides thetaiotaomicron

76510
77013

NC_012781.1

Eubacterium rectale

1183363
1183959

NZ_AAVN02000002.1

Collinsella aerofaciens

330907
330182

NZ_DS996456.1

Parabacteroides johnsonii

448969
448454

NZ_DS996921.1

Bacteroides pectinophilus

215363
215845

NZ_JH724300.1

Bacteroides xylanisolvens

14445
13921

NZ_AAVN02000002.1

Collinsella aerofaciens

331231
331860

NZ_DS996921.1

Bacteroides pectinophilus

2180486
2181052

CVOZ01000033.1

Bacteroides thetaiotaomicron

39992
39123

CVOZ01000033.1

Bacteroides thetaiotaomicron

38164
37274

JGCP01001040.1

Bacteroides fragilis

1038
415

JGCP01001049.1

Bacteroides fragilis

113
619

JGCP01001118.1

Bacteroides fragilis

510
25

NC_000913.3

Escherichia coli

806660
806118

NC_009614.1

Bacteroides vulgatus

2317377
2318246

NC_009614.1

Bacteroides vulgatus

2352958
2353836

NZ_AAVM02000003.1

Bacteroides caccae

186200
186913

NZ_AAVM02000003.1

Bacteroides caccae

188146
189024

NZ_AAVN02000002.1

Collinsella aerofaciens

333085
331844

NZ_ABJL02000008.1

Bacteroides intestinalis

2827911
2827084

NZ_ABJL02000008.1

Bacteroides intestinalis

2825593
2824715

NZ_ABJL02000008.1

Bacteroides intestinalis

2763149
2762139

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

194890
194012

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

192550
191672

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

116394
115324

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

32407
33276

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

34236
35126

NZ_DS264581.1

Bacteroides ovatus

361113
361889

NZ_DS264581.1

Bacteroides ovatus

372065
372856

NZ_DS264584.1

Bacteroides ovatus

300282
301151

NZ_DS264584.1

Bacteroides ovatus

302363
303262

NZ_DS264584.1

Bacteroides ovatus

314236
313235

NZ_DS480674.1

Clostridium bolteae

63437
62442

NZ_DS499676.1

Bacteroides stercoris

560446
559568

NZ_DS499676.1

Bacteroides stercoris

562585
561713

NZ_DS499676.1

Bacteroides stercoris

526258
525236

NZ_DS990238.1

Bifidobacterium longum

757614
756904

NZ_DS995509.1

Bacteroides eggerthii

326173
327018

NZ_DS995509.1

Bacteroides eggerthii

328317
329195

NZ_DS995536.1

Bacteroides dorei

285685
284816

NZ_DS995536.1

Bacteroides dorei

241608
240730

NZ_DS996923.1

Bacteroides pectinophilus

73704
72955

NZ_EQ973491.1

Bacteroides cellulosilyticus

391606
392484

NZ_EQ973491.1

Bacteroides cellulosilyticus

393946
394824

NZ_EQ973491.1

Bacteroides cellulosilyticus

464286
465356

NZ_GG688320.1

Bacteroides finegoldii

266145
265276

NZ_GG688320.1

Bacteroides finegoldii

264126
263248

NZ_GG688320.1

Bacteroides finegoldii

254019
255143

NZ_GG688326.1

Bacteroides finegoldii

33875
33099

NZ_GG688326.1

Bacteroides finegoldii

22923
22132

NZ_GG692728.1

Roseburia intestinalis

82828
83886

NZ_GG703853.1

Prevotella copri

101373
100462

NZ_GG704864.1

Enterobacter cancerogenus

507462
506914

NZ_JH724294.1

Bacteroides xylanisolvens

389193
390062

NZ_JH724294.1

Bacteroides xylanisolvens

391274
392140

NZ_JH724295.1

Bacteroides xylanisolvens

1554618
1555394

NZ_JH724295.1

Bacteroides xylanisolvens

1565570
1566361

NZ_PUEM01000006.1

Clostridium bolteae

5178002
5177007

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

898508
899377

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

900337
901227

NZ_PUEP01000005.1

Bacteroides ovatus

3145467
3144598

NZ_PUEP01000005.1

Bacteroides ovatus

3143386
3142487

NZ_PUEP01000005.1

Bacteroides ovatus

3789254
3788478

NZ_PUEP01000005.1

Bacteroides ovatus

3778302
3777511

NZ_PUEP01000005.1

Bacteroides ovatus

3131513
3132514

NZ_PUEQ01000003.1

Bacteroides caccae

2518776
2517907

NZ_PUEQ01000003.1

Bacteroides caccae

2516829
2515951

BACDOR_00571

1
57

BACDOR_03988

41
155

BT_1006

1
62

BT_1148

5
170

CVOZ01000044.1

Bacteroides thetaiotaomicron

270178
270675

CVOZ01000063.1

Bacteroides thetaiotaomicron

213252
213776

JGCP01002451.1

Bacteroides fragilis

27278
27826

JGCP01002532.1

Bacteroides fragilis

1990
1631

NC_009614.1

Bacteroides vulgatus

2553345
2553821

NC_009614.1

Bacteroides vulgatus

1289396
1288902

NC_009614.1

Bacteroides vulgatus

3238578
3238234

NC_009615.1

Parabacteroides distasonis

2044483
2044857

NC_012781.1

Eubacterium rectale

1600354
1600857

NZ_AAVM02000001.1

Bacteroides caccae

1119727
1119179

NZ_AAVN02000007.1

Collinsella aerofaciens

43328
42810

NZ_AAXA02000015.1

Dorea formicigenerans

428152
428658

NZ_AAXA02000015.1

Dorea formicigenerans

812485
812937

NZ_AAYG02000005.1

Ruminococcus gnavus

169559
170014

NZ_ABJL02000007.1

Bacteroides intestinalis

959642
959145

NZ_ABJL02000008.1

Bacteroides intestinalis

574710
574237

NZ_ABXA01000037.1

Anaerococcus hydrogenalis

15300
14881

NZ_ACCL02000007.1

Marvinbryantia formatexigens

30299
30799

NZ_ACEP01000002.1

Eubacterium hallii

34255
34773

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

1579899
1579402

NZ_ATFI01000012.1

Bacteroides cellulosilyticus

48936
48463

NZ_CVOY01000042.1

Bacteroides thetaiotaomicron

62958
62434

NZ_CVOY01000048.1

Bacteroides thetaiotaomicron

31368
31865

NZ_DS264270.1

Eubacterium ventriosum

212238
212747

NZ_DS264542.1

Parabacteroides merdae

249192
248833

NZ_DS264582.1

Bacteroides ovatus

368681
369235

NZ_DS362244.1

Bacteroides uniformis

170469
171023

NZ_DS362248.1

Bacteroides uniformis

308163
308660

NZ_DS480690.1

Clostridium bolteae

244844
244341

NZ_DS480692.1

Clostridium bolteae

142185
141841

NZ_DS499659.1

Erysipelatoclostridium ramosum

548774
548271

NZ_DS499672.1

Bacteroides stercoris

113154
113663

NZ_DS499674.1

Bacteroides stercoris

145536
146033

NZ_DS499701.1

Clostridium scindens

43478
43023

NZ_DS544193.1

Anaerotruncus colihominis

200258
200770

NZ_DS562846.1

Clostridium spiroforme

146418
145852

NZ_DS981517.1

Clostridium sporogenes

2367346
2367882

NZ_DS981518.1

Clostridium sporogenes

524044
524544

NZ_DS990201.1

Ruminococcus lactaris

50105
50611

NZ_DS995510.1

Bacteroides eggerthii

730877
731395

NZ_DS995511.1

Bacteroides eggerthii

244997
245494

NZ_DS995534.1

Bacteroides dorei

71640
71146

NZ_DS995536.1

Bacteroides dorei

38622
38146

NZ_DS995537.1

Bacteroides dorei

674814
674470

NZ_DS996446.1

Parabacteroides johnsonii

59119
59580

NZ_DS996841.1

Holdemanella biformis

240823
240320

NZ_DS996844.1

Holdemanella biformis

9201
9716

NZ_DS996847.1

Holdemanella biformis

35952
36299

NZ_DS996921.1

Bacteroides pectinophilus

1377570
1378040

NZ_EQ973490.1

Bacteroides cellulosilyticus

1771262
1770765

NZ_EQ973492.1

Bacteroides cellulosilyticus

269763
270236

NZ_EQ973631.1

Bacteroides coprophilus

166069
166566

NZ_EQ973635.1

Bacteroides coprophilus

157971
157465

NZ_EQ973650.1

Bacteroides coprophilus

309678
310139

NZ_EQ973651.1

Bacteroides coprophilus

186918
186481

NZ_GG657587.1

Clostridium asparagiforme

626172
625822

NZ_GG657592.1

Clostridium asparagiforme

256639
256139

NZ_GG657592.1

Clostridium asparagiforme

2004022
2003468

NZ_GG662014.1

Coprococcus comes

263241
263747

NZ_GG662014.1

Coprococcus comes

272780
273106

NZ_GG688323.1

Bacteroides finegoldii

185574
185020

NZ_GG688343.1

Bacteroides finegoldii

10025
9510

NZ_GG692710.1

Collinsella intestinalis

212696
213166

NZ_GG692721.1

Roseburia intestinalis

15573
16079

NZ_GG698591.1

Blautia hansenii

291863
291519

NZ_GG703859.1

Prevotella copri

138307
138801

NZ_GG704769.1

Subdoligranulum variabile

1245783
1245277

NZ_GG704774.1

Subdoligranulum variabile

1821
2216

NZ_JGDE01000083.1

Bacteroides fragilis

52785
53333

NZ_JGDE01000126.1

Bacteroides fragilis

19699
19340

NZ_JH370371.1

Alistipes indistinctus

1289779
1289264

NZ_JH724294.1

Bacteroides xylanisolvens

1743283
1743837

NZ_KE993038.1

Clostridium symbiosum

28571
29017

NZ_MTWC01000003.1

Clostridioides difficile

851741
852091

NZ_MTWC01000003.1

Clostridioides difficile

764221
764625

NZ_MTWC01000003.1

Clostridioides difficile

3694907
3694437

NZ_MTWD01000001.1

Clostridioides difficile

951757
952107

NZ_MTWD01000001.1

Clostridioides difficile

864279
864683

NZ_MTWD01000001.1

Clostridioides difficile

3699874
3699404

NZ_MTWE01000004.1

Clostridioides difficile

3086150
3086656

NZ_MTWE01000004.1

Clostridioides difficile

644554
644913

NZ_MTWE01000004.1

Clostridioides difficile

562111
562515

NZ_MTWE01000004.1

Clostridioides difficile

3362803
3362396

NZ_MTWF01000010.1

Clostridioides difficile

538758
539108

NZ_MTWF01000010.1

Clostridioides difficile

451169
451573

NZ_MTWF01000021.1

Clostridioides difficile

734579
734109

NZ_PPUH01000002.1

Eggerthella lenta

235541
236044

NZ_PUEL01000004.1

Ruminococcus gnavus

215261
214806

NZ_PUEM01000006.1

Clostridium bolteae

4914472
4913969

NZ_PUEM01000006.1

Clostridium bolteae

4326890
4327234

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

3235791
3235294

NZ_PUEP01000005.1

Bacteroides ovatus

1680428
1679874

NZ_PUEQ01000003.1

Bacteroides caccae

1408538
1407990

NZ_UFTH01000001.1

Bacteroides fragilis

4377477
4378025

NZ_UFTH01000001.1

Bacteroides fragilis

627443
627084

NZ_UFTH01000002.1

Bacteroides fragilis

31675
32046

JGCP01000859.1

Bacteroides fragilis

247
660

JGCP01002352.1

Bacteroides fragilis

14649
15062

NC_000913.3

Escherichia coli

3231665
3233218

NC_008618.1

Bifidobacterium adolescentis

1689422
1688412

NC_009614.1

Bacteroides vulgatus

1477586
1477173

NC_012781.1

Eubacterium rectale

2728515
2729615

NZ_AAVM02000002.1

Bacteroides caccae

251699
252112

NZ_AAVN02000002.1

Collinsella aerofaciens

326185
324458

NZ_AAVN02000008.1

Collinsella aerofaciens

49145
47112

NZ_AAYG02000005.1

Ruminococcus gnavus

53408
52044

NZ_AAYG02000005.1

Ruminococcus gnavus

53906
53610

NZ_AAYG02000018.1

Ruminococcus gnavus

115281
114544

NZ_AAYG02000018.1

Ruminococcus gnavus

114545
113859

NZ_AAYG02000020.1

Ruminococcus gnavus

33742
31967

NZ_ABXW01000007.1

Providencia alcalifaciens

83384
82374

NZ_ABXW01000014.1

Providencia alcalifaciens

201354
200305

NZ_ABXW01000019.1

Providencia alcalifaciens

39201
39665

NZ_ABXW01000047.1

Providencia alcalifaciens

151003
149450

NZ_ACCL02000002.1

Marvinbryantia formatexigens

238233
239315

NZ_ACEP01000036.1

Eubacterium hallii

20427
18634

NZ_ACEP01000036.1

Eubacterium hallii

6263
6859

NZ_ACEP01000054.1

Eubacterium hallii

38370
37309

NZ_AHVA01000007.1

Salmonella enterica

585091
586644

NZ_DS264365.1

Ruminococcus torques

38444
36861

NZ_DS264366.1

Ruminococcus torques

14189
12285

NZ_DS264366.1

Ruminococcus torques

12251
10338

NZ_DS264374.1

Ruminococcus torques

22043
20577

NZ_DS264376.1

Ruminococcus torques

81045
82469

NZ_DS264579.1

Bacteroides ovatus

391612
392025

NZ_DS480725.1

Clostridium bolteae

73291
75168

NZ_DS499653.1

Erysipelatoclostridium ramosum

163876
161984

NZ_DS499655.1

Erysipelatoclostridium ramosum

92494
94494

NZ_DS499659.1

Erysipelatoclostridium ramosum

820298
822214

NZ_DS499659.1

Erysipelatoclostridium ramosum

187711
189624

NZ_DS499659.1

Erysipelatoclostridium ramosum

830720
828918

NZ_DS499659.1

Erysipelatoclostridium ramosum

818839
819687

NZ_DS499659.1

Erysipelatoclostridium ramosum

811198
809723

NZ_DS499659.1

Erysipelatoclostridium ramosum

818320
818655

NZ_DS499674.1

Bacteroides stercoris

281199
280756

NZ_DS499678.1

Clostridium scindens

34299
33472

NZ_DS499684.1

Clostridium scindens

29932
31860

NZ_DS499697.1

Clostridium scindens

295175
293268

NZ_DS499710.1

Clostridium scindens

88907
87510

NZ_DS499710.1

Clostridium scindens

82861
81515

NZ_DS499710.1

Clostridium scindens

83371
83048

NZ_DS499710.1

Clostridium scindens

89399
89103

NZ_DS607663.1

Providencia stuartii

624169
623150

NZ_DS607678.1

Providencia stuartii

131768
133240

NZ_DS981517.1

Clostridium sporogenes

1504597
1506570

NZ_DS990176.1

Ruminococcus lactaris

30347
30943

NZ_DS990176.1

Ruminococcus lactaris

29846
30169

NZ_DS990190.1

Ruminococcus lactaris

3899
2472

NZ_DS990238.1

Bifidobacterium longum

255030
254731

NZ_DS990238.1

Bifidobacterium longum

255196
255005

NZ_DS995534.1

Bacteroides dorei

335106
334693

NZ_DS996444.1

Parabacteroides johnsonii

867248
867835

NZ_DS996841.1

Holdemanella biformis

213342
211348

NZ_DS996841.1

Holdemanella biformis

215261
213360

NZ_DS996841.1

Holdemanella biformis

167745
166951

NZ_DS996841.1

Holdemanella biformis

168255
167947

NZ_DS996842.1

Holdemanella biformis

294507
293134

NZ_DS996844.1

Holdemanella biformis

11340
9940

NZ_GG657591.1

Clostridium asparagiforme

187173
186097

NZ_GG657592.1

Clostridium asparagiforme

3032918
3034684

NZ_GG657592.1

Clostridium asparagiforme

1876564
1874570

NZ_GG657592.1

Clostridium asparagiforme

3069663
3067939

NZ_GG657592.1

Clostridium asparagiforme

2542323
2540860

NZ_GG661994.1

Proteus penneri

222623
221616

NZ_GG661996.1

Proteus penneri

924601
925488

NZ_GG661996.1

Proteus penneri

924431
924589

NZ_GG661996.1

Proteus penneri

923938
924240

NZ_GG662014.1

Coprococcus comes

645523
644906

NZ_GG662014.1

Coprococcus comes

646024
645701

NZ_GG667620.1

Hungatella hathewayi

7252
6188

NZ_GG667622.1

Hungatella hathewayi

37613
39523

NZ_GG667690.1

Hungatella hathewayi

16181
14763

NZ_GG667690.1

Hungatella hathewayi

14690
13062

NZ_GG667690.1

Hungatella hathewayi

16682
16383

NZ_GG688332.1

Bacteroides finegoldii

98265
98678

NZ_GG692710.1

Collinsella intestinalis

1185313
1183391

NZ_GG692717.1

Roseburia intestinalis

224174
223578

NZ_GG692717.1

Roseburia intestinalis

224675
224352

NZ_GG692736.1

Roseburia intestinalis

17269
15341

NZ_GG704769.1

Subdoligranulum variabile

78938
80308

NZ_GG704769.1

Subdoligranulum variabile

2209221
2208253

NZ_GG704771.1

Subdoligranulum variabile

256941
258851

NZ_GG704865.1

Enterobacter cancerogenus

770824
771876

NZ_GG704865.1

Enterobacter cancerogenus

770338
770634

NZ_GG705262.1

Providencia rettgeri

1574659
1576197

NZ_GG705262.1

Providencia rettgeri

701537
702553

NZ_GG705263.1

Providencia rettgeri

326238
325780

NZ_GG729830.1

Bifidobacterium breve

608625
609662

NZ_GG739633.1

Edwardsiella tarda

1475528
1475019

NZ_JGDE01000165.1

Bacteroides fragilis

75469
75882

NZ_JH724295.1

Bacteroides xylanisolvens

710795
711208

NZ_KE992800.1

Clostridium symbiosum

26653
24728

NZ_KE992800.1

Clostridium symbiosum

28977
30416

NZ_MTWC01000003.1

Clostridioides difficile

3079200
3078121

NZ_MTWC01000003.1

Clostridioides difficile

2889511
2888225

NZ_MTWC01000003.1

Clostridioides difficile

2890009
2889704

NZ_MTWD01000001.1

Clostridioides difficile

3091419
3090340

NZ_MTWD01000001.1

Clostridioides difficile

2930504
2929218

NZ_MTWD01000001.1

Clostridioides difficile

2931002
2930697

NZ_MTWE01000004.1

Clostridioides difficile

3102040
3100103

NZ_MTWE01000004.1

Clostridioides difficile

2802748
2801669

NZ_MTWE01000004.1

Clostridioides difficile

2648868
2647582

NZ_MTWE01000004.1

Clostridioides difficile

2649366
2649061

NZ_MTWF01000021.1

Clostridioides difficile

150497
149418

NZ_PPUH01000004.1

Eggerthella lenta

75047
76951

NZ_PPUH01000004.1

Eggerthella lenta

77693
78493

NZ_PPUH01000004.1

Eggerthella lenta

174728
175240

NZ_PUEL01000004.1

Ruminococcus gnavus

2242708
2240789

NZ_PUEL01000004.1

Ruminococcus gnavus

820113
822041

NZ_PUEL01000004.1

Ruminococcus gnavus

1519478
1517703

NZ_PUEL01000004.1

Ruminococcus gnavus

331413
332777

NZ_PUEL01000004.1

Ruminococcus gnavus

657923
656505

NZ_PUEL01000004.1

Ruminococcus gnavus

2201457
2200561

NZ_PUEL01000004.1

Ruminococcus gnavus

330915
331211

NZ_PUEM01000006.1

Clostridium bolteae

2793257
2795134

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

1043585
1044007

NZ_PUEP01000005.1

Bacteroides ovatus

4630286
4629873

NZ_PUEQ01000003.1

Bacteroides caccae

3370211
3369798

NZ_UFTH01000001.1

Bacteroides fragilis

1975000
1975413

QEKH01000021.1

Victivallis vadensis

49835
50419

BACDOR_03937

52
92

BT_1192

37
160

CVOZ01000002.1

Bacteroides thetaiotaomicron

27472
28101

CVOZ01000011.1

Bacteroides thetaiotaomicron

27140
27421

NC_000913.3

Escherichia coli

499727
499083

NC_012781.1

Eubacterium rectale

2291176
2290535

NZ_AAVN02000008.1

Collinsella aerofaciens

95394
94330

NZ_AAXA02000008.1

Dorea formicigenerans

69701
70546

NZ_AAXA02000008.1

Dorea formicigenerans

71748
72386

NZ_AAXA02000009.1

Dorea formicigenerans

62902
62264

NZ_AAYG02000031.1

Ruminococcus gnavus

40641
39991

NZ_ABXWO1000046.1

Providencia alcalifaciens

144717
144040

NZ_ACCL02000001.1

Marvinbryantia formatexigens

132276
132626

NZ_ATFI01000001.1

Bacteroides cellulosilyticus

965679
965404

NZ_DS264269.1

Eubacterium ventriosum

21943
23007

NZ_DS264517.1

Parabacteroides merdae

22275
22898

NZ_DS480686.1

Clostridium bolteae

99911
99264

NZ_DS499709.1

Clostridium scindens

27922
27179

NZ_DS544180.1

Anaerotruncus colihominis

47523
48269

NZ_DS981517.1

Clostridium sporogenes

1498487
1499116

NZ_DS990176.1

Ruminococcus lactaris

24402
24085

NZ_DS996453.1

Parabacteroides johnsonii

2536
1919

NZ_DS996921.1

Bacteroides pectinophilus

1518411
1519052

NZ_EQ973490.1

Bacteroides cellulosilyticus

1170390
1170115

NZ_GG657590.1

Clostridium asparagiforme

216404
215709

NZ_GG657591.1

Clostridium asparagiforme

525486
524806

NZ_GG657592.1

Clostridium asparagiforme

1824491
1824808

NZ_GG657592.1

Clostridium asparagiforme

958061
957219

NZ_GG657592.1

Clostridium asparagiforme

1368813
1368559

NZ_GG657595.1

Clostridium asparagiforme

413311
412655

NZ_GG661997.1

Proteus penneri

158305
158997

NZ_GG662010.1

Coprococcus comes

133481
132858

NZ_GG667612.1

Hungatella hathewayi

83476
84156

NZ_GG667653.1

Hungatella hathewayi

9768
10541

NZ_GG667663.1

Hungatella hathewayi

28932
29255

NZ_GG688324.1

Bacteroides finegoldii

191844
191179

NZ_GG692718.1

Roseburia intestinalis

13388
12747

NZ_GG692729.1

Roseburia intestinalis

23802
23545

NZ_GG703854.1

Prevotella copri

344197
344454

NZ_GG703864.1

Prevotella copri

76937
77305

NZ_GG704769.1

Subdoligranulum variabile

569661
570269

NZ_GG704770.1

Subdoligranulum variabile

279973
280239

NZ_GG704867.1

Enterobacter cancerogenus

32796
32065

NZ_GG705262.1

Providencia rettgeri

737987
738844

NZ_GG739633.1

Edwardsiella tarda

2215417
2214740

NZ_KE992946.1

Clostridium symbiosum

16142
16942

NZ_PUEL01000004.1

Ruminococcus gnavus

1068338
1067598

NZ_PUEM01000006.1

Clostridium bolteae

3409802
3410449

NZ_PUEO01000004.1

Bacteroides thetaiotaomicron

909868
909239

QEKH01000003.1

Victivallis vadensis

74432
75064

QEKH01000014.1

Victivallis vadensis

38351
38740

QEKH01000019.1

Victivallis vadensis

58559
57939

NC_012781.1

Eubacterium rectale

3213966
3213511

NC_012781.1

Eubacterium rectale

3389503
3389354

NZ_AAVN02000015.1

Collinsella aerofaciens

28383
27748

NZ_DS996455.1

Parabacteroides johnsonii

38505
38065

NZ_DS996923.1

Bacteroides pectinophilus

151384
150950

NZ_GG662014.1

Coprococcus comes

572680
573108

NZ_GG692710.1

Collinsella intestinalis

1019998
1020606

NZ_GG704769.1

Subdoligranulum variabile

1665742
1666170

NZ_MTWE01000004.1

Clostridioides difficile

130482
130892

NZ_DS499679.1

Clostridium scindens

6626
6823

NZ_DS499680.1

Clostridium scindens

39909
40277

NZ_DS499698.1

Clostridium scindens

86368
86784

NZ_GG692724.1

Roseburia intestinalis

114328
114747

NZ_GG692735.1

Roseburia intestinalis

3089
3505

NZ_GG692775.1

Roseburia intestinalis

9058
9255

NZ_GG692775.1

Roseburia intestinalis

9246
9338

NZ_GG692783.1

Roseburia intestinalis

258
347

NZ_DS264270.1

Eubacterium ventriosum

117297
117686

NZ_DS264270.1

Eubacterium ventriosum

117008
117298

NZ_DS499698.1

Clostridium scindens

87519
86782

NZ_DS499700.1

Clostridium scindens

21096
20401

NZ_GG662007.1

Coprococcus comes

543307
543696

NZ_GG662007.1

Coprococcus comes

543102
543311

NZ_GG703852.1

Prevotella copri

145367
145672

NZ_GG703860.1

Prevotella copri

53657
53133

NZ_GG703860.1

Prevotella copri

54778
54395

NC_008618.1

Bifidobacterium adolescentis

964374
964060

NC_012781.1

Eubacterium rectale

992985
993416

NC_012781.1

Eubacterium rectale

1393674
1394102

NZ_AAVN02000001.1

Collinsella aerofaciens

457597
458028

NZ_AAVN02000002.1

Collinsella aerofaciens

91743
90853

NZ_AAXA02000006.1

Dorea formicigenerans

4930
4118

NZ_AAXA02000007.1

Dorea formicigenerans

75838
76302

NZ_AAXA02000012.1

Dorea formicigenerans

143739
143305

NZ_AAXA02000014.1

Dorea formicigenerans

8125
8556

NZ_AAXA02000014.1

Dorea formicigenerans

9822
10076

NZ_AAXA02000015.1

Dorea formicigenerans

114251
113727

NZ_AAXA02000016.1

Dorea formicigenerans

118699
118268

NZ_ABXA01000032.1

Anaerococcus hydrogenalis

34181
34612

NZ_ABXA01000043.1

Anaerococcus hydrogenalis

135344
135775

NZ_ABXW01000049.1

Providencia alcalifaciens

145285
145707

NZ_ACCL02000001.1

Marvinbryantia formatexigens

57072
56389

NZ_ACCL02000014.1

Marvinbryantia formatexigens

117997
118428

NZ_ACCL02000014.1

Marvinbryantia formatexigens

75359
75772

NZ_ACCL02000033.1

Marvinbryantia formatexigens

13896
13381

NZ_ACEP01000042.1

Eubacterium hallii

5704
5186

NZ_ACEP01000171.1

Eubacterium hallii

13836
13606

NZ_AHVA01000007.1

Salmonella enterica

612224
611889

NZ_AHVA01000007.1

Salmonella enterica

380642
380214

NZ_DS264265.1

Eubacterium ventriosum

210966
210535

NZ_DS264270.1

Eubacterium ventriosum

218825
219256

NZ_DS264344.1

Ruminococcus torques

61376
60936

NZ_DS480671.1

Clostridium bolteae

257033
256143

NZ_DS480671.1

Clostridium bolteae

83250
82915

NZ_DS480680.1

Clostridium bolteae

299464
299204

NZ_DS480690.1

Clostridium bolteae

111366
111980

NZ_DS480694.1

Clostridium bolteae

234643
233795

NZ_DS480694.1

Clostridium bolteae

405777
405625

NZ_DS480694.1

Clostridium bolteae

311382
311744

NZ_DS480694.1

Clostridium bolteae

371292
371077

NZ_DS480723.1

Clostridium bolteae

101986
101747

NZ_DS499654.1

Erysipelatoclostridium ramosum

170533
170264

NZ_DS499654.1

Erysipelatoclostridium ramosum

200127
200339

NZ_DS499655.1

Erysipelatoclostridium ramosum

450584
451015

NZ_DS499655.1

Erysipelatoclostridium ramosum

542015
542440

NZ_DS499656.1

Erysipelatoclostridium ramosum

185343
185780

NZ_DS499660.1

Erysipelatoclostridium ramosum

11106
11321

NZ_DS499680.1

Clostridium scindens

6317
6895

NZ_DS499691.1

Clostridium scindens

857
36

NZ_DS499694.1

Clostridium scindens

1192
683

NZ_DS499698.1

Clostridium scindens

88546
87611

NZ_DS499705.1

Clostridium scindens

87758
87324

NZ_DS499710.1

Clostridium scindens

106171
105356

NZ_DS499714.1

Clostridium scindens

7330
7908

NZ_DS499718.1

Clostridium scindens

379001
378474

NZ_DS544185.1

Anaerotruncus colihominis

244252
243629

NZ_DS544185.1

Anaerotruncus colihominis

232765
232478

NZ_DS544188.1

Anaerotruncus colihominis

264851
264282

NZ_DS544193.1

Anaerotruncus colihominis

198228
198013

NZ_DS562853.1

Clostridium spiroforme

198492
198923

NZ_DS562853.1

Clostridium spiroforme

337920
338357

NZ_DS607663.1

Providencia stuartii

885247
885516

NZ_DS607670.1

Providencia stuartii

93145
93360

NZ_DS981517.1

Clostridium sporogenes

2147870
2148421

NZ_DS981518.1

Clostridium sporogenes

505394
504957

NZ_DS981518.1

Clostridium sporogenes

896212
896361

NZ_DS990163.1

Ruminococcus lactaris

69898
69683

NZ_DS990202.1

Ruminococcus lactaris

150898
151329

NZ_DS990239.1

Bifidobacterium longum

417566
416994

NZ_DS996841.1

Holdemanella biformis

302699
303286

NZ_DS996843.1

Holdemanella biformis

156961
157398

NZ_DS996846.1

Holdemanella biformis

91009
90554

NZ_DS996921.1

Bacteroides pectinophilus

1770364
1769933

NZ_GG657587.1

Clostridium asparagiforme

197966
198217

NZ_GG657587.1

Clostridium asparagiforme

484513
484328

NZ_GG657587.1

Clostridium asparagiforme

462837
462550

NZ_GG657587.1

Clostridium asparagiforme

568461
568700

NZ_GG657589.1

Clostridium asparagiforme

86677
87105

NZ_GG657590.1

Clostridium asparagiforme

174026
174313

NZ_GG657590.1

Clostridium asparagiforme

132367
131576

NZ_GG657591.1

Clostridium asparagiforme

926075
926557

NZ_GG657592.1

Clostridium asparagiforme

2125178
2125744

NZ_GG657592.1

Clostridium asparagiforme

2150188
2149304

NZ_GG657592.1

Clostridium asparagiforme

35707
35865

NZ_GG657592.1

Clostridium asparagiforme

54324
54085

NZ_GG657592.1

Clostridium asparagiforme

2149209
2148745

NZ_GG657592.1

Clostridium asparagiforme

1241014
1241166

NZ_GG657592.1

Clostridium asparagiforme

53378
53037

NZ_GG657592.1

Clostridium asparagiforme

2939085
2939318

NZ_GG657592.1

Clostridium asparagiforme

253538
253311

NZ_GG657592.1

Clostridium asparagiforme

1931348
1931782

NZ_GG657592.1

Clostridium asparagiforme

1199059
1198841

NZ_GG657592.1

Clostridium asparagiforme

1304859
1305089

NZ_GG657592.1

Clostridium asparagiforme

2964883
2964650

NZ_GG657592.1

Clostridium asparagiforme

1583120
1583629

NZ_GG657676.1

Clostridium asparagiforme

122
361

NZ_GG662007.1

Coprococcus comes

232709
232482

NZ_GG662010.1

Coprococcus comes

47027
46236

NZ_GG662010.1

Coprococcus comes

147979
147725

NZ_GG662012.1

Coprococcus comes

9623
10057

NZ_GG662014.1

Coprococcus comes

261751
261320

NZ_GG667610.1

Hungatella hathewayi

84423
83608

NZ_GG667612.1

Hungatella hathewayi

35585
35040

NZ_GG667612.1

Hungatella hathewayi

51608
51405

NZ_GG667615.1

Hungatella hathewayi

61630
62061

NZ_GG667627.1

Hungatella hathewayi

29759
30193

NZ_GG667675.1

Hungatella hathewayi

6837
6418

NZ_GG692710.1

Collinsella intestinalis

133099
132209

NZ_GG692719.1

Roseburia intestinalis

139466
139038

NZ_GG692742.1

Roseburia intestinalis

31102
30953

NZ_GG698588.1

Blautia hansenii

886407
886556

NZ_GG704770.1

Subdoligranulum variabile

299826
299407

NZ_GG704865.1

Enterobacter cancerogenus

800444
800235

NZ_GG705267.1

Providencia rettgeri

240910
241179

NZ_GG729830.1

Bifidobacterium breve

1203629
1203057

NZ_GG739633.1

Edwardsiella tarda

295285
296013

NZ_GG739633.1

Edwardsiella tarda

756703
756912

NZ_KB946519.1

Enterococcus faecalis

1294830
1294402

NZ_KE136402.1

Enterococcus faecalis

1806226
1806654

NZ_KE992790.1

Clostridium symbiosum

1050
787

NZ_KE992799.1

Clostridium symbiosum

48485
48258

NZ_KE992855.1

Clostridium symbiosum

65420
64728

NZ_KE993024.1

Clostridium symbiosum

34019
34249

NZ_MTWC01000003.1

Clostridioides difficile

1879743
1879994

NZ_MTWD01000001.1

Clostridioides difficile

1922488
1922739

NZ_MTWE01000004.1

Clostridioides difficile

1625560
1625811

NZ_MTWE01000004.1

Clostridioides difficile

3637126
3636857

NZ_PUEL01000004.1

Ruminococcus gnavus

2325881
2326312

NZ_PUEM01000006.1

Clostridium bolteae

5802124
5802972

NZ_PUEM01000006.1

Clostridium bolteae

2707890
2708324

NZ_PUEM01000006.1

Clostridium bolteae

3193896
3193006

NZ_PUEM01000006.1

Clostridium bolteae

5630991
5631143

NZ_PUEM01000006.1

Clostridium bolteae

199448
199687

NZ_PUEM01000006.1

Clostridium bolteae

5725385
5725023

NZ_PUEM01000006.1

Clostridium bolteae

5665475
5665690

NZ_PUEM01000006.1

Clostridium bolteae

3020114
3019779

NZ_PUEM01000006.1

Clostridium bolteae

627804
627544

NZ_PUEM01000006.1

Clostridium bolteae

4780997
4781611

CVOZ01000058.1

Bacteroides thetaiotaomicron

302431
301628

CVOZ01000085.1

Bacteroides thetaiotaomicron

880
71

JGCP01000704.1

Bacteroides fragilis

2340
1621

JGCP01002431.1

Bacteroides fragilis

3248
2439

NC_000913.3

Escherichia coli

3081620
3080886

NC_000913.3

Escherichia coli

2579708
2580382

NC_008618.1

Bifidobacterium adolescentis

1034957
1035538

NC_009614.1

Bacteroides vulgatus

519272
518451

NC_009614.1

Bacteroides vulgatus

2993131
2992328

NC_009615.1

Parabacteroides distasonis

1971560
1972303

NC_010655.1

Akkermansia muciniphila

622533
623279

NC_012781.1

Eubacterium rectale

2329440
2328679

NC_012781.1

Eubacterium rectale

301575
302372

NZ_AAVM02000004.1

Bacteroides caccae

384982
384179

NZ_AAVN02000005.1

Collinsella aerofaciens

62689
63486

NZ_AAVN02000007.1

Collinsella aerofaciens

30286
31083

NZ_AAXA02000015.1

Dorea formicigenerans

777173
777955

NZ_ABJL02000008.1

Bacteroides intestinalis

710350
709553

NZ_ABJL02000008.1

Bacteroides intestinalis

872763
873572

NZ_ABXA01000019.1

Anaerococcus hydrogenalis

83461
84240

NZ_ABXA01000044.1

Anaerococcus hydrogenalis

26244
26918

NZ_ABXWO1000004.1

Providencia alcalifaciens

192888
193562

NZ_ACCL02000033.1

Marvinbryantia formatexigens

24594
25394

NZ_ACEP01000106.1

Eubacterium hallii

34351
35028

NZ_ACEP01000106.1

Eubacterium hallii

8467
9270

NZ_AHVA01000007.1

Salmonella enterica

437205
436471

NZ_ATFI01000008.1

Bacteroides cellulosilyticus

669051
668242

NZ_CVOY01000079.1

Bacteroides thetaiotaomicron

7940
7137

NZ_DS264265.1

Eubacterium ventriosum

121947
121150

NZ_DS264270.1

Eubacterium ventriosum

131247
130783

NZ_DS264282.1

Eubacterium ventriosum

44941
44159

NZ_DS264382.1

Ruminococcus torques

15883
16695

NZ_DS264541.1

Parabacteroides merdae

51592
50846

NZ_DS264563.1

Bacteroides ovatus

129699
128896

NZ_DS362241.1

Bacteroides uniformis

26081
26899

NZ_DS362248.1

Bacteroides uniformis

10119
9310

NZ_DS480669.1

Clostridium bolteae

172089
171322

NZ_DS480671.1

Clostridium bolteae

270573
271247

NZ_DS480676.1

Clostridium bolteae

208866
208069

NZ_DS480683.1

Clostridium bolteae

59202
58459

NZ_DS480723.1

Clostridium bolteae

62571
63365

NZ_DS499654.1

Erysipelatoclostridium ramosum

493613
494332

NZ_DS499659.1

Erysipelatoclostridium ramosum

506177
505422

NZ_DS499673.1

Bacteroides stercoris

364819
364016

NZ_DS499698.1

Clostridium scindens

88763
89650

NZ_DS499698.1

Clostridium scindens

61808
61131

NZ_DS499703.1

Clostridium scindens

55717
56514

NZ_DS499718.1

Clostridium scindens

274306
273629

NZ_DS544176.1

Anaerotruncus colihominis

236326
237081

NZ_DS544185.1

Anaerotruncus colihominis

120251
119532

NZ_DS544186.1

Anaerotruncus colihominis

57092
56349

NZ_DS544190.1

Anaerotruncus colihominis

45026
45862

NZ_DS544190.1

Anaerotruncus colihominis

194039
194773

NZ_DS562849.1

Clostridium spiroforme

87327
88040

NZ_DS607683.1

Providencia stuartii

286938
287612

NZ_DS981517.1

Clostridium sporogenes

154420
155220

NZ_DS990163.1

Ruminococcus lactaris

134129
134908

NZ_DS990241.1

Bifidobacterium longum

301034
300396

NZ_DS995509.1

Bacteroides eggerthii

1008704
1007901

NZ_DS995528.1

Bacteroides dorei

103973
104794

NZ_DS995535.1

Bacteroides dorei

358028
357237

NZ_DS995537.1

Bacteroides dorei

338316
337513

NZ_DS996445.1

Parabacteroides johnsonii

267454
266708

NZ_DS996843.1

Holdemanella biformis

245401
244601

NZ_DS996843.1

Holdemanella biformis

234112
233342

NZ_DS996850.1

Holdemanella biformis

117033
116224

NZ_DS996923.1

Bacteroides pectinophilus

107404
106727

NZ_EQ973495.1

Bacteroides cellulosilyticus

691462
692142

NZ_EQ973646.1

Bacteroides coprophilus

145177
144512

NZ_GG657587.1

Clostridium asparagiforme

820313
821107

NZ_GG657587.1

Clostridium asparagiforme

605673
604999

NZ_GG657589.1

Clostridium asparagiforme

122006
121344

NZ_GG657592.1

Clostridium asparagiforme

2356902
2356078

NZ_GG657592.1

Clostridium asparagiforme

2681628
2680816

NZ_GG657595.1

Clostridium asparagiforme

403564
402791

NZ_GG657595.1

Clostridium asparagiforme

346373
345594

NZ_GG661996.1

Proteus penneri

638905
638231

NZ_GG662008.1

Coprococcus comes

8233
7436

NZ_GG667643.1

Hungatella hathewayi

42915
43706

NZ_GG667648.1

Hungatella hathewayi

3211
2381

NZ_GG667661.1

Hungatella hathewayi

10879
11589

NZ_GG667677.1

Hungatella hathewayi

17130
17855

NZ_GG667681.1

Hungatella hathewayi

22622
21810

NZ_GG667686.1

Hungatella hathewayi

4731
4012

NZ_GG688324.1

Bacteroides finegoldii

86190
85387

NZ_GG692711.1

Collinsella intestinalis

24582
23785

NZ_GG692731.1

Roseburia intestinalis

6046
5264

NZ_GG692741.1

Roseburia intestinalis

5968
5225

NZ_GG698590.1

Blautia hansenii

337693
338493

NZ_GG703852.1

Prevotella copri

583896
584642

NZ_GG704769.1

Subdoligranulum variabile

60450
61163

NZ_GG704769.1

Subdoligranulum variabile

15116
14370

NZ_GG704770.1

Subdoligranulum variabile

5362
6141

NZ_GG704770.1

Subdoligranulum variabile

214747
215493

NZ_GG704772.1

Subdoligranulum variabile

45873
45049

NZ_GG704863.1

Enterobacter cancerogenus

2013656
2012844

NZ_GG704863.1

Enterobacter cancerogenus

2101556
2102290

NZ_GG704865.1

Enterobacter cancerogenus

539453
538719

NZ_GG705265.1

Providencia rettgeri

100618
99944

NZ_GG705267.1

Providencia rettgeri

66251
65577

NZ_GG729830.1

Bifidobacterium breve

1233732
1233157

NZ_GG739632.1

Edwardsiella tarda

145991
145257

NZ_JGDE01000063.1

Bacteroides fragilis

109546
108737

NZ_JH370371.1

Alistipes indistinctus

595517
596176

NZ_JH724294.1

Bacteroides xylanisolvens

1474036
1473233

NZ_KB946519.1

Enterococcus faecalis

1168242
1168913

NZ_KE136402.1

Enterococcus faecalis

1933289
1932618

NZ_KE992967.1

Clostridium symbiosum

16072
15284

NZ_MTWC01000003.1

Clostridioides difficile

2436150
2435359

NZ_MTWC01000003.1

Clostridioides difficile

3800319
3799558

NZ_MTWD01000001.1

Clostridioides difficile

2478316
2477525

NZ_MTWD01000001.1

Clostridioides difficile

3805291
3804530

NZ_MTWE01000004.1

Clostridioides difficile

2193127
2192336

NZ_MTWE01000004.1

Clostridioides difficile

3465381
3464620

NZ_PUEL01000004.1

Ruminococcus gnavus

2090336
2089539

NZ_PUEL01000004.1

Ruminococcus gnavus

2665987
2666715

NZ_PUEM01000006.1

Clostridium bolteae

2861084
2861881

NZ_PUEM01000006.1

Clostridium bolteae

6480829
6480086

NZ_PUEM01000006.1

Clostridium bolteae

5430429
5429662

NZ_PUEM01000006.1

Clostridium bolteae

238864
238070

NZ_PUEM01000006.1

Clostridium bolteae

3207435
3208109

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

2219764
2218961

NZ_PUEP01000005.1

Bacteroides ovatus

2020302
2021105

NZ_PUEQ01000003.1

Bacteroides caccae

1665493
1666296

NZ_UFTH01000001.1

Bacteroides fragilis

3881025
3880216

QEKH01000003.1

Victivallis vadensis

96465
97208

CVOZ01000033.1

Bacteroides thetaiotaomicron

56026
56922

JGCP01000335.1

Bacteroides fragilis

10772
11557

JGCP01000867.1

Bacteroides fragilis

965
1840

JGCP01001597.1

Bacteroides fragilis

61154
60237

JGCP01002379.1

Bacteroides fragilis

46606
45821

NC_000913.3

Escherichia coli

439100
438342

NC_009614.1

Bacteroides vulgatus

518419
517508

NC_009614.1

Bacteroides vulgatus

2260819
2259929

NC_009615.1

Parabacteroides distasonis

3159114
3158230

NC_010655.1

Akkermansia muciniphila

372524
373408

NC_010655.1

Akkermansia muciniphila

1056059
1055319

NC_012781.1

Eubacterium rectale

302528
303298

NC_012781.1

Eubacterium rectale

2328598
2327729

NC_012781.1

Eubacterium rectale

2064027
2063158

NZ_AAVM02000003.1

Bacteroides caccae

171018
170122

NZ_AAVN02000003.1

Collinsella aerofaciens

103150
102221

NZ_AAVN02000005.1

Collinsella aerofaciens

63590
64447

NZ_AAVN02000007.1

Collinsella aerofaciens

31218
32021

NZ_AAXA02000003.1

Dorea formicigenerans

25120
25917

NZ_AAXA02000014.1

Dorea formicigenerans

48489
49244

NZ_AAXA02000015.1

Dorea formicigenerans

778056
778868

NZ_ABJL02000008.1

Bacteroides intestinalis

709463
708594

NZ_ABJL02000008.1

Bacteroides intestinalis

2841895
2842785

NZ_ABXA01000019.1

Anaerococcus hydrogenalis

84625
85167

NZ_ABXW01000004.1

Providencia alcalifaciens

141254
140499

NZ_ACCL02000030.1

Marvinbryantia formatexigens

4571
5425

NZ_ACCL02000033.1

Marvinbryantia formatexigens

25451
26320

NZ_ACEP01000011.1

Eubacterium hallii

19574
20422

NZ_ACEP01000106.1

Eubacterium hallii

9431
10198

NZ_ACEP01000106.1

Eubacterium hallii

35117
36001

NZ_ATFI01000004.1

Bacteroides cellulosilyticus

209297
210172

NZ_CVOY01000004.1

Bacteroides thetaiotaomicron

16373
15477

NZ_DS264265.1

Eubacterium ventriosum

120994
120227

NZ_DS264270.1

Eubacterium ventriosum

130607
129840

NZ_DS264282.1

Eubacterium ventriosum

44042
43233

NZ_DS264284.1

Eubacterium ventriosum

144020
143178

NZ_DS264344.1

Ruminococcus torques

6063
6932

NZ_DS264382.1

Ruminococcus torques

16851
17627

NZ_DS264543.1

Parabacteroides merdae

27784
28650

NZ_DS264584.1

Bacteroides ovatus

284623
283748

NZ_DS362220.1

Bacteroides uniformis

227049
227918

NZ_DS362248.1

Bacteroides uniformis

9278
8370

NZ_DS480669.1

Clostridium bolteae

171259
170429

NZ_DS480676.1

Clostridium bolteae

208042
207137

NZ_DS480683.1

Clostridium bolteae

58433
57519

NZ_DS480686.1

Clostridium bolteae

79885
79166

NZ_DS480723.1

Clostridium bolteae

63515
64309

NZ_DS480723.1

Clostridium bolteae

15660
16472

NZ_DS499654.1

Erysipelatoclostridium ramosum

494370
495266

NZ_DS499659.1

Erysipelatoclostridium ramosum

270170
269349

NZ_DS499659.1

Erysipelatoclostridium ramosum

466874
467341

NZ_DS499676.1

Bacteroides stercoris

578064
578954

NZ_DS499697.1

Clostridium scindens

60279
61052

NZ_DS499698.1

Clostridium scindens

89655
90635

NZ_DS499698.1

Clostridium scindens

61039
60128

NZ_DS499703.1

Clostridium scindens

56487
57446

NZ_DS544176.1

Anaerotruncus colihominis

237039
237902

NZ_DS544183.1

Anaerotruncus colihominis

240611
240078

NZ_DS544185.1

Anaerotruncus colihominis

119250
118453

NZ_DS544186.1

Anaerotruncus colihominis

56292
55369

NZ_DS544190.1

Anaerotruncus colihominis

45937
46782

NZ_DS544190.1

Anaerotruncus colihominis

195009
195800

NZ_DS562849.1

Clostridium spiroforme

120673
120311

NZ_DS607683.1

Providencia stuartii

189914
189132

NZ_DS981517.1

Clostridium sporogenes

155283
156140

NZ_DS981517.1

Clostridium sporogenes

1854924
1855802

NZ_DS990163.1

Ruminococcus lactaris

134998
135867

NZ_DS990181.1

Ruminococcus lactaris

125472
124558

NZ_DS990181.1

Ruminococcus lactaris

82189
81734

NZ_DS995509.1

Bacteroides eggerthii

308482
307574

NZ_DS995528.1

Bacteroides dorei

104826
105737

NZ_DS995535.1

Bacteroides dorei

357120
356392

NZ_DS995536.1

Bacteroides dorei

378895
379785

NZ_DS996456.1

Parabacteroides johnsonii

290834
289962

NZ_DS996842.1

Holdemanella biformis

160953
161444

NZ_DS996843.1

Holdemanella biformis

233309
232410

NZ_DS996843.1

Holdemanella biformis

244454
243681

NZ_DS996843.1

Holdemanella biformis

154069
154917

NZ_DS996850.1

Holdemanella biformis

116083
115316

NZ_DS996926.1

Bacteroides pectinophilus

25856
26650

NZ_EQ973491.1

Bacteroides cellulosilyticus

377200
376325

NZ_EQ973643.1

Bacteroides coprophilus

652762
653538

NZ_GG657587.1

Clostridium asparagiforme

821211
822050

NZ_GG657589.1

Clostridium asparagiforme

120718
120140

NZ_GG657591.1

Clostridium asparagiforme

587188
587907

NZ_GG657592.1

Clostridium asparagiforme

2680669
2679878

NZ_GG657592.1

Clostridium asparagiforme

2356058
2355147

NZ_GG657595.1

Clostridium asparagiforme

345552
344704

NZ_GG657595.1

Clostridium asparagiforme

402646
401852

NZ_GG661996.1

Proteus penneri

791418
792179

NZ_GG662007.1

Coprococcus comes

99625
98906

NZ_GG662008.1

Coprococcus comes

7280
6615

NZ_GG667622.1

Hungatella hathewayi

66639
67460

NZ_GG667643.1

Hungatella hathewayi

43732
44676

NZ_GG667648.1

Hungatella hathewayi

2203
1409

NZ_GG667661.1

Hungatella hathewayi

11831
12583

NZ_GG667677.1

Hungatella hathewayi

17929
18831

NZ_GG667681.1

Hungatella hathewayi

21744
21016

NZ_GG667686.1

Hungatella hathewayi

3887
2979

NZ_GG688317.1

Bacteroides finegoldii

362276
363025

NZ_GG688320.1

Bacteroides finegoldii

281488
282357

NZ_GG692711.1

Collinsella intestinalis

23654
22830

NZ_GG692711.1

Collinsella intestinalis

69274
68498

NZ_GG692726.1

Roseburia intestinalis

50658
51503

NZ_GG692731.1

Roseburia intestinalis

5084
4749

NZ_GG692731.1

Roseburia intestinalis

4582
4208

NZ_GG692741.1

Roseburia intestinalis

5015
4245

NZ_GG693674.1

Lactobacillus reuteri

15204
14458

NZ_GG698589.1

Blautia hansenii

218497
219342

NZ_GG698590.1

Blautia hansenii

338622
339425

NZ_GG703865.1

Prevotella copri

41671
42546

NZ_GG704769.1

Subdoligranulum variabile

14262
13399

NZ_GG704769.1

Subdoligranulum variabile

61204
62076

NZ_GG704769.1

Subdoligranulum variabile

963668
963213

NZ_GG704770.1

Subdoligranulum variabile

6326
7123

NZ_GG704770.1

Subdoligranulum variabile

215601
216464

NZ_GG704772.1

Subdoligranulum variabile

44998
44135

NZ_GG704863.1

Enterobacter cancerogenus

2012671
2011880

NZ_GG704864.1

Enterobacter cancerogenus

137859
137101

NZ_GG705265.1

Providencia rettgeri

155499
156254

NZ_GG705267.1

Providencia rettgeri

65114
64578

NZ_GG729830.1

Bifidobacterium breve

720986
720603

NZ_GG739633.1

Edwardsiella tarda

373885
373130

NZ_JDUD01000004.1

Bifidobacterium breve

259935
260318

NZ_JGDE01000029.1

Bacteroides fragilis

56625
55840

NZ_JGDE01000151.1

Bacteroides fragilis

69580
68663

NZ_JH370371.1

Alistipes indistinctus

1294336
1295106

NZ_JH724294.1

Bacteroides xylanisolvens

373560
372685

NZ_KB946519.1

Enterococcus faecalis

955995
956768

NZ_KE136402.1

Enterococcus faecalis

2137928
2137155

NZ_KE992967.1

Clostridium symbiosum

15212
14295

NZ_MTWC01000003.1

Clostridioides difficile

2435248
2434466

NZ_MTWC01000003.1

Clostridioides difficile

3799403
3798573

NZ_MTWC01000003.1

Clostridioides difficile

1160536
1161309

NZ_MTWD01000001.1

Clostridioides difficile

2477414
2476632

NZ_MTWD01000001.1

Clostridioides difficile

3804375
3803584

NZ_MTWD01000001.1

Clostridioides difficile

1257043
1257816

NZ_MTWD01000001.1

Clostridioides difficile

73882
74589

NZ_MTWE01000004.1

Clostridioides difficile

2192225
2191443

NZ_MTWE01000004.1

Clostridioides difficile

3464465
3463635

NZ_MTWE01000004.1

Clostridioides difficile

960760
961533

NZ_PUEL01000004.1

Ruminococcus gnavus

2089383
2088613

NZ_PUEL01000004.1

Ruminococcus gnavus

2666757
2667680

NZ_PUEL01000004.1

Ruminococcus gnavus

794583
793762

NZ_PUEM01000006.1

Clostridium bolteae

5429599
5428769

NZ_PUEM01000006.1

Clostridium bolteae

2861908
2862813

NZ_PUEM01000006.1

Clostridium bolteae

237920
237126

NZ_PUEM01000006.1

Clostridium bolteae

6480060
6479146

NZ_PUEM01000006.1

Clostridium bolteae

3429828
3430547

NZ_PUEM01000006.1

Clostridium bolteae

285775
284963

NZ_PUEO01000014.1

Bacteroides thetaiotaomicron

882473
881577

NZ_PUEP01000005.1

Bacteroides ovatus

3161127
3162002

NZ_PUEQ01000003.1

Bacteroides caccae

2533958
2534854

NZ_UFTH01000001.1

Bacteroides fragilis

2923509
2922724

NZ_UFTH01000001.1

Bacteroides fragilis

1585432
1584515

QEKH01000019.1

Victivallis vadensis

59802
59029

CVOZ01000028.1

Bacteroides thetaiotaomicron

11708
11028

CVOZ01000041.1

Bacteroides thetaiotaomicron

276698
276060

JGCP01000929.1

Bacteroides fragilis

984
1961

JGCP01001512.1

Bacteroides fragilis

86
724

JGCP01002412.1

Bacteroides fragilis

4520
5224

NC_000913.3

Escherichia coli

1858800
1858150

NC_000913.3

Escherichia coli

1653876
1653256

NC_000913.3

Escherichia coli

3791303
3790323

NC_000913.3

Escherichia coli

2172858
2172232

NC_000913.3

Escherichia coli

1861305
1860268

NC_000913.3

Escherichia coli

4494313
4493675

NC_000913.3

Escherichia coli

2675722
2674703

NC_000913.3

Escherichia coli

4596053
4596487

NC_000913.3

Escherichia coli

4496182
4495505

NC_000913.3

Escherichia coli

379529
378861

NC_008618.1

Bifidobacterium adolescentis

412571
413026

NC_008618.1

Bifidobacterium adolescentis

417228
418223

NC_009614.1

Bacteroides vulgatus

341339
342010

NC_009614.1

Bacteroides vulgatus

4657957
4657250

NC_009615.1

Parabacteroides distasonis

1570183
1569347

NC_009615.1

Parabacteroides distasonis

2557870
2557166

NC_010655.1

Akkermansia muciniphila

292548
291571

NC_010655.1

Akkermansia muciniphila

2578712
2579362

NC_012781.1

Eubacterium rectale

1291708
1292388

NZ_AAVM02000004.1

Bacteroides caccae

12927
13637

NZ_AAYG02000009.1

Ruminococcus gnavus

126809
127438

NZ_AAYG02000009.1

Ruminococcus gnavus

97702
98343

NZ_ABJL02000008.1

Bacteroides intestinalis

1955633
1955031

NZ_ABJL02000008.1

Bacteroides intestinalis

2224108
2223404

NZ_ABXW01000004.1

Providencia alcalifaciens

273231
272242

NZ_ABXW01000070.1

Providencia alcalifaciens

85714
84734

NZ_ACCL02000009.1

Marvinbryantia formatexigens

148973
147954

NZ_ACCL02000012.1

Marvinbryantia formatexigens

119480
120445

NZ_ACCL02000023.1

Marvinbryantia formatexigens

25242
24913

NZ_ACCL02000041.1

Marvinbryantia formatexigens

6824
5856

NZ_AHVA01000007.1

Salmonella enterica

629177
629791

NZ_AHVA01000007.1

Salmonella enterica

443202
442726

NZ_ATFI01000005.1

Bacteroides cellulosilyticus

148491
147889

NZ_ATFI01000005.1

Bacteroides cellulosilyticus

281258
280554

NZ_CVOY01000006.1

Bacteroides thetaiotaomicron

74981
74301

NZ_CVOY01000028.1

Bacteroides thetaiotaomicron

60888
60250

NZ_DS264270.1

Eubacterium ventriosum

132077
133096

NZ_DS264356.1

Ruminococcus torques

135544
134918

NZ_DS264356.1

Ruminococcus torques

138887
137853

NZ_DS264581.1

Bacteroides ovatus

127382
127984

NZ_DS264584.1

Bacteroides ovatus

820339
821043

NZ_DS362249.1

Bacteroides uniformis

410760
410056

NZ_DS480663.1

Clostridium bolteae

23590
22595

NZ_DS480674.1

Clostridium bolteae

133468
132818

NZ_DS480677.1

Clostridium bolteae

49418
50098

NZ_DS480679.1

Clostridium bolteae

3487
2807

NZ_DS480681.1

Clostridium bolteae

101114
100101

NZ_DS480681.1

Clostridium bolteae

102205
101171

NZ_DS480683.1

Clostridium bolteae

55885
54905

NZ_DS480685.1

Clostridium bolteae

12651
11935

NZ_DS499659.1

Erysipelatoclostridium ramosum

699981
700592

NZ_DS499667.1

Bacteroides stercoris

9893
10597

NZ_DS499698.1

Clostridium scindens

90702
91751

NZ_DS499700.1

Clostridium scindens

26495
25524

NZ_DS499701.1

Clostridium scindens

129720
128749

NZ_DS499706.1

Clostridium scindens

53386
54207

NZ_DS499706.1

Clostridium scindens

60521
61132

NZ_DS499706.1

Clostridium scindens

79791
80414

NZ_DS499706.1

Clostridium scindens

26668
27222

NZ_DS499706.1

Clostridium scindens

49864
50862

NZ_DS499718.1

Clostridium scindens

277445
276753

NZ_DS544175.1

Anaerotruncus colihominis

165749
166231

NZ_DS544175.1

Anaerotruncus colihominis

34216
34839

NZ_DS544185.1

Anaerotruncus colihominis

127019
126309

NZ_DS544190.1

Anaerotruncus colihominis

38245
39264

NZ_DS607671.1

Providencia stuartii

138632
139612

NZ_DS981517.1

Clostridium sporogenes

1442433
1443440

NZ_DS981517.1

Clostridium sporogenes

128139
128786

NZ_DS981517.1

Clostridium sporogenes

1549649
1550068

NZ_DS990194.1

Ruminococcus lactaris

63868
63188

NZ_DS995508.1

Bacteroides eggerthii

161989
161351

NZ_DS995531.1

Bacteroides dorei

1763
1143

NZ_DS995533.1

Bacteroides dorei

81701
82408

NZ_DS995533.1

Bacteroides dorei

169186
169599

NZ_DS996842.1

Holdemanella biformis

209702
208998

NZ_EQ973491.1

Bacteroides cellulosilyticus

1310769
1311371

NZ_EQ973491.1

Bacteroides cellulosilyticus

1172397
1173101

NZ_EQ973637.1

Bacteroides coprophilus

197189
197566

NZ_GG657587.1

Clostridium asparagiforme

63925
64557

NZ_GG657587.1

Clostridium asparagiforme

528913
529482

NZ_GG657591.1

Clostridium asparagiforme

956107
956775

NZ_GG657591.1

Clostridium asparagiforme

483157
483576

NZ_GG657591.1

Clostridium asparagiforme

577856
578869

NZ_GG657591.1

Clostridium asparagiforme

710248
710910

NZ_GG657592.1

Clostridium asparagiforme

1127425
1126616

NZ_GG657592.1

Clostridium asparagiforme

1430381
1431352

NZ_GG657592.1

Clostridium asparagiforme

2752837
2753874

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Number	Name	Date	Kind
5863560	Osborne	Jan 1999	A
7482115	Scott et al.	Jan 2009	B2
20110218216	Vivek et al.	Sep 2011	A1
20150064138	Lu et al.	Mar 2015	A1

Number	Date	Country
63007191	Apr 2020	US
63132190	Dec 2020	US
63137998	Jan 2021	US
63137989	Jan 2021	US

Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders

Information

Patent Number

Date Filed

Date Issued

Inventors

Original Assignees

Examiners

Agents

CPC

Field of Search

CPC

International Classifications

Abstract

Description

Claims

US Referenced Citations (4)

Foreign Referenced Citations (7)

Non-Patent Literature Citations (60)

Related Publications (1)

Provisional Applications (4)

Number	Date	Country
WO2014124226	Aug 2014	WO
WO2017009399	Jan 2019	WO
WO2020181178	Sep 2020	WO
WO2020181180	Sep 2020	WO
WO2020181193	Sep 2020	WO
WO2020181195	Sep 2020	WO
WO2020181202	Sep 2020	WO

Entry
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Sheth et al. 2017; Manipulating bacterial communities by in situ microbiome engineering. Tends Genet. 32(4): 189-200.
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Gil-Cruz et al. 2019; Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science. 366:881-886 plus Supplemental Materials pp. 1-34.
Abudayyeh ey al., RNA targeting with CRISPR-Cas13a, Nature. Oct. 12, 2017; 550(7675): 280-284.
Anne et al., Protein Secretion in Gram-Positive Bacteria: From Multiple Pathways to Biotechnology, Springer International Publishing Switzerland 2016, Current Topics in Microbiology and Immunology, 1-42.
Anzalone et al., Search-and-replace genome editing without double-strand breaks or donor DNA, Nature. Dec. 2019; 576(7785): 149-157.
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Gaudelli et al., Programmable base editing of A⋅T to G⋅C in genomic DNA without DNA cleavage, Nature. Nov. 23, 2017; 551(7681): 464-471.
Gil-Cruz et al., Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy, Science 366, 881-886 (2019).
Greiling et al., Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus, Sci Transl Med. Mar. 28, 2018; 10(434), 1-33.
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