Molecular cardiotoxicology modeling

Abstract
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
Description
SEQUENCE LISTING SUBMISSION ON COMPACT DISC

The Sequence Listing submitted concurrently herewith on compact disc under 37 C.F.R. §§1.821(c) and 1.821(e) is herein incorporated by reference in its entirety. Three copies of the Sequence Listing, one on each of three compact discs are provided. Copy 1 and Copy 2 are identical. Copies 1 and 2 are also identical to the CRF. Each electronic copy of the Sequence Listing was created on Jan. 2, 2003 with a file size of 4046 KB. The file names are as follows: Copy 1—g15090us01.txt; Copy 2—g15090us01.txt; and CRF—g15090us01.txt.


BACKGROUND OF THE INVENTION

The need for methods of assessing the toxic impact of a compound, pharmaceutical agent or environmental pollutant on a cell or living organism has led to the development of procedures which utilize living organisms as biological monitors. The simplest and most convenient of these systems utilize unicellular microorganisms such as yeast and bacteria, since they are the most easily maintained and manipulated. In addition, unicellular screening systems often use easily detectable changes in phenotype to monitor the effect of test compounds on the cell. Unicellular organisms, however, are inadequate models for estimating the potential effects of many compounds on complex multicellular animals, in part because they do not have the ability to carry out biotransformations to the extent or at levels found in higher organisms.


The biotransformation of chemical compounds by multicellular organisms is a significant factor in determining the overall toxicity of agents to which they are exposed. Accordingly, multicellular screening systems may be preferred or required to detect the toxic effects of compounds. The use of multicellular organisms as toxicology screening tools has been significantly hampered, however, by the lack of convenient screening mechanisms or endpoints, such as those available in yeast or bacterial systems. In addition, previous attempts to produce toxicology prediction systems have failed to provide the necessary modeling data and statistical information to accurately predict toxic responses (e.g., WO 00/12760, WO 00/47761, WO 00/63435, WO 01/32928, and WO 01/38579).


SUMMARY OF THE INVENTION

The present invention is based, in part, on the elucidation of the global changes in gene expression in tissues or cells exposed to known toxins, in particular cardiotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure.


In various aspects, the invention includes methods of predicting at least one toxic effect of a compound, predicting the progression of a toxic effect of a compound, and predicting the cardiotoxicity of a compound. The invention also includes methods of identifying agents that modulate the onset or progression of a toxic response. Also provided are methods of predicting the cellular pathways that a compound modulates in a cell. The invention also includes methods of identifying agents that modulate protein activities.


In a further aspect, the invention includes probes comprising sequences that specifically hybridize to genes in Tables 1-5LL. Also included are solid supports comprising at least two of the previously mentioned probes. The invention also includes a computer system that has a database containing information identifying the expression level in a tissue or cell sample exposed to a cardiotoxin of a set of genes comprising at least two genes in Tables 1-5LL.


The invention further provides a core set of genes in Tables 5A-5LL from which probes can be made and attached to solid supports. These core genes serve as a preferred set of markers of cardiotoxicity and can be used with the methods of the invention to predict or monitor a toxic effect of a compound or to modulate the onset or progression of a toxic response.


DETAILED DESCRIPTION

Many biological functions are accomplished by altering the expression of various genes through transcriptional (e.g. through control of initiation, provision of RNA precursors, RNA processing, etc.) and/or translational control. For example, fundamental biological processes such as cell cycle, cell differentiation and cell death are often characterized by the variations in the expression levels of groups of genes.


Changes in gene expression are also associated with the effects of various chemicals, drugs, toxins, pharmaceutical agents and pollutants on an organism or cell(s). For example, the lack of sufficient expression of functional tumor suppressor genes and/or the over-expression of oncogene/protooncogenes after exposure to an agent could lead to tumorgenesis or hyperplastic growth of cells (Marshall (1991), Cell 64: 313-326; Weinberg (1991), Science 254: 1138-1146). Thus, changes in the expression levels of particular genes (e.g. oncogenes or tumor suppressors) may serve as signposts for the presence and progression of toxicity or other cellular responses to exposure to a particular compound.


Monitoring changes in gene expression may also provide certain advantages during drug screening and development. Often drugs are screened for the ability to interact with a major target without regard to other effects the drugs have on cells. These cellular effects may cause toxicity in the whole animal, which prevents the development and clinical use of the potential drug.


The present inventors have examined tissue from animals exposed to known cardiotoxins which induce detrimental heart effects, to identify global changes in gene expression and individual changes in gene expression induced by these compounds. These global changes in gene expression, which can be detected by the production of expression profiles (an expression level of one or more genes), provide useful toxicity markers that can be used to monitor toxicity and/or toxicity progression by a test compound. Some of these markers may also be used to monitor or detect various disease or physiological states, disease progression, drug efficacy and drug metabolism.


Identification of Toxicity Markers


To evaluate and identify gene expression changes that are predictive of toxicity, studies using selected compounds with well characterized toxicity have been conducted by the present inventors to catalogue altered gene expression during exposure in vivo. In the present study, cyclophosphamide, ifosfamide, minoxidil, hydralazine, BI-QT, clenbuterol, isoproterenol, norepinephrine, epinephrine, adriamycin, amphotericin B, epirubicin, phenylpropanolamine, and rosiglitazone were selected as known cardiotoxins. Cisplatin, PAN, dopamine, acyclovir, carboplatin, etoposide, temozolomide, and vancomycin were selected as negative controls.


Cyclophosphamide, an alkylating agent, is highly toxic to dividing cells and is commonly used in chemotherapy to treat non-Hodgkin's lymphomas, Burkitt's lymphoma and carcinomas of the lung, breast, and ovary (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., p.1234, 1237-1239, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). Additionally, cyclophosphamide is used as an immunosuppressive agent in bone marrow transplantation and following organ transplantation. Though cyclophosphamide is therapeutically useful, it is also associated with cardiotoxicity, nephrotoxicity, and hemorrhagic cystitis. Once in the liver, cyclophosphamide is hydroxylated by the cytochrome P450 mixed function oxidase system. The active metabolites, phosphoramide mustard and acrolein, cross-link DNA and cause growth arrest and cell death. Acrolein has been shown to decrease cellular glutathione levels (Dorr and Lagel (1994), Chem Biol Interact 93: 117-128).


The cardiotoxic effects of cyclophosphamide have been partially elucidated. One study analyzed plasma levels in 19 women with metastatic breast carcinoma who had been treated with cyclophosphamide, thiotepa, and carboplatin (Ayash et al. (1992), J Clin Oncol 10: 995-1000). Of the 19 women in the study, six developed moderate congestive heart failure. In another case study, a 10-year old boy, who had been treated with high-dose cyclophosphamide, developed cardiac arrhythmias and intractable hypotension (Tsai et al. (1990), Am J Pediatr Hematol Oncol 12: 472-476). The boy died 23 days after the transplantation.


Another clinical study examined the relationship between the amount of cyclophosphamide administered and the development of cardiotoxicity (Goldberg et al. (1986), Blood 68: 1114-1118). When the cyclophosphamide dosage was ≦1.55 g/m2/d, only 1 out of 32 patients had symptoms consistent with cyclophosphamide cardiotoxicity. Yet when the dosage was greater than 1.55 g/m2/d, 13 out of 52 patients were symptomatic. Six of the high-dose patients died of congestive heart failure.


In a related study, Braverman et al. compared the effects of once daily low-dose administration of cyclophosphamide (87+/−11 mg/kg) and twice-daily high-dose treatment (174+/−34 mg/kg) on bone marrow transplantation patients (Braverman et al. (1991), J Clin Oncol 9: 1215-1223). Within a week, the high-dose patients had an increase in left ventricular mass index. Out of five patients who developed clinical cardiotoxicity, four were in the high-dose group.


Ifosfamide, an oxazaphosphorine, is an analog of cyclophosphamide. Whereas cyclophosphamide has two chloroethyl groups on the exocyclic nitrogen, ifosfamide contains one chloroethyl group on the ring nitrogen and the other on the exocyclic nitrogen. Ifosfamide is a nitrogen mustard and alkylating agent, commonly used in chemotherapy to treat testicular, cervical, and lung cancer, as well as sarcomas and lymphomas. Like cyclophosphamide, it is activated in the liver by hydroxylation, but it reacts more slowly and produces more dechlorinated metabolites and chloroacetaldehyde. Comparatively higher doses of ifosfamide are required to match the efficacy of cyclophosphamide.


Alkylating agents can cross-link DNA, resulting in growth arrest and cell death. Despite its therapeutic value, ifosfamide is associated with nephrotoxicity (affecting the proximal and distal renal tubules), urotoxicity, venooclusive disease, myelosuppression, pulmonary fibrosis and central neurotoxicity (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., p.1234-1240, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). Ifosfamide can also cause acute severe heart failure and malignant ventricular arrhythmia, which may be reversible. Death from cardiogenic shock has also been reported (Cecil Textbook of Medicine 20th ed., Bennett et al. eds., p. 331, W. B. Saunders Co., Philadelphia, 1996).


Studies of patients with advanced or resistant lymphomas or carcinomas showed that high-dose ifosfamide treatment produced various symptoms of cardiac disease, including dyspnea, tachycardia, decreased left ventricular contractility and malignant ventricular arrhythmia (Quezado et al. (1993), Ann Intern Med 118: 31-36; Wilson et al. (1992), J Clin Oncol 19: 1712-1722). Other patient studies have noted that ifosfamide-induced cardiac toxicity may be asymptomatic, although it can be detected by electrocardiogram and should be monitored (Pai et al.(2000), Drug Saf 22: 263-302).


Minoxidil is an antihypertensive medicinal agent used in the treatment of high blood pressure. It works by relaxing blood vessels so that blood may pass through them more easily, thereby lowering blood pressure. By applying minoxidil to the scalp, it has recently been shown to be effective at combating hair loss by stimulating hair growth. Once minoxidil is metabolized by hepatic sulfotransferase, it is converted to the active molecule minoxidil N—O sulfate (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., pp. 796-797, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). The active minoxidil sulfate stimulates the ATP-modulated potassium channel consequently causing hyperpolarization and relaxation of smooth muscle. Early studies on minoxidil demonstrated that following a single dose of the drug, patients suffering from left ventricular failure exhibited a slightly increased heart rate, a fall in the mean arterial pressure, a fall in the systemic vascular resistance, and a slight increase in cardiac index (Franciosa and Cohn (1981) Circulation 63: 652-657).


Some common side effects associated with minoxidil treatment are an increase in hair growth, weight gain, and a fast or irregular heartbeat. More serious side effects are numbness of the hands, feet, or face, chest pain, shortness of breath, and swelling of the feet or lower legs. Because of the risks of fluid retention and reflex cardiovascular effects, minoxidil is often given concomitantly with a diuretic and a sympatholytic drug.


While minoxidil is effective at lowering blood pressure, it does not lead to a regression of cardiac hypertrophy. To the contrary, minoxidil has been shown to cause cardiac enlargement when administered to normotensive animals (Moravec et al. (1994) J Pharmacol Exp Ther 269: 290-296). Moravec et al. examined normotensive rats that had developed myocardial hypertrophy following treatment with minoxidil. The authors found that minoxidil treatment led to enlargement of the left ventricle, right ventricle, and interventricular septum.


Another rat study investigated the age- and dose-dependency of minoxidil-induced cardiotoxicity (Herman et al. (1996) Toxicology 110: 71-83). Rats ranging in age from 3 months to 2 years were given varying amounts of minoxidil over the period of two days. The investigators observed interstitial hemorrhages at all dose levels, however the hemorrhages were more frequent and severe in the older animals. The 2 year old rats had vascular lesions composed of arteriolar damage and calcification.


Hydralazine, an antihypertensive drug, causes relaxation of arteriolar smooth muscle. Such vasodilation is linked to vigorous stimulation of the sympathetic nervous system, which in turn leads to increased heart rate and contractility, increased plasma renin activity, and fluid retention (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., p. 794, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). The increased renin activity leads to an increase in angiotensin II, which in turn causes stimulation of aldosterone and sodium reabsorption.


Hydralazine is used for the treatment of high blood pressure (hypertension) and for the treatment of pregnant women suffering from high blood pressure (pre-eclampsia or eclampsia). Some common side effects associated with hydralazine use are diarrhea, rapid heartbeat, headache, decreased appetite, and nausea. Hydralazine is often used concomitantly with drugs that inhibit sympathetic activity to combat the mild pulmonary hypertension that can be associated with hydralazine usage.


In one hydralazine study, rats were given one of five cardiotoxic compounds (isoproterenol, hydralazine, caffeine, cyclophosphamide, or adriamycin) by intravenous injection (Kemi et al. (1996), J Vet Med Sci 58: 699-702). At one hour and four hours post-dose, early focal myocardial lesions were observed histopathologically. Lesions were observed in the rats treated with hydralazine four hours post-dose. The lesions were found in the inner one third of the left ventricular walls including the papillary muscles.


Another study compared the effects of isoproterenol, hydralazine and minoxidil on young and mature rats (Hanton et al. (1991), Res Commun Chem Pathol Pharmacol 71: 231-234). Myocardial necrosis was observed in both age groups, but it was more severe in the mature rats. Hypotension and reflex tachycardia were also seen in the hydralazine-treated rats.


BI-QT has been shown to induce QC prolongation in dogs and liver alterations in rats. Over a four week period, dogs treated with BI-QT exhibited sedation, decreased body weight, increased liver weight, and slightly increased levels of AST, ALP, and BUN. After three months of treatment, the dogs exhibited signs of cardiovascular effects.


Clenbuterol, a β2 adrenergic agonist, can be used therapeutically as a bronchial dilator for asthmatics. It also has powerful muscle anabolic and lipolytic effects. It has been banned in the United States but continues to be used illegally by athletes to increase muscle growth. In a number of studies, rats treated with clenbuterol developed hypertrophy of the heart and latissimus dorsi muscle (Doheny et al. (1998), Amino Acids 15: 13-25; Murphy et al. (1999), Proc Soc Exp Biol Med 221: 184-187; Petrou et al. (1995), Circulation 92:11483-11489).


In one study, mares treated with therapeutic levels of clenbuterol were compared to mares that were exercised and mares in a control group (Sleeper et al. (2002), Med Sci Sports Exerc 34: 643-650). The clenbuterol-treated mares demonstrated significantly higher left ventricular internal dimension and interventricular septal wall thickness at end diastole. In addition, the clenbuterol-treated mares had significantly increased aortic root dimensions, which could lead to an increased chance of aortic rupture.


In another study, investigators reported a case of acute clenbuterol toxicity in a human (Hoffman et al. (2001), J Toxicol 39: 339-344). A 28-year old woman had ingested a small quantity of clenbuterol, and the patient developed sustained sinus tachycardia, hypokalemia, hypophosphatemia, and hypomagnesemia.


Catecholamines are neurotransmitters that are synthesized in the adrenal medulla and in the sympathetic nervous system. Epinephrine, norepinephrine, and isoproterenol are members of the catecholamine sympathomimetic amine family (Casarett & Doull's Toxicology, The Basic Science of Poisons 6th ed., p. 618-619, C. D. Klaassen, Ed., McGraw Hill, New York, 2001). They are chemically similar by having an aromatic portion (catechol) to which is attached an amine, or nitrogen-containing group.


Isoproterenol, an antiarrhythmic agent, is used therapeutically as a bronchodilator for the treatment of asthma, chronic bronchitis, emphysema, and other lung diseases. Some side effects of usage are myocardial ischemia, arrhythmias, angina, hypertension, and tachycardia. As a β receptor agonist, isoproterenol exerts direct positive inotropic and chronotropic effects. Peripheral vascular resistance is decreased along with the pulse pressure and mean arterial pressure. However, the heart rate increases due to the decrease in the mean arterial pressure.


Norepinephrine, an α and β receptor agonist, is also known as noradrenaline. It is involved in behaviors such as attention and general arousal, stress, and mood states. By acting on β-1 receptors, it causes increased peripheral vascular resistance, pulse pressure and mean arterial pressure. Reflex bradycardia occurs due to the increase in mean arterial pressure. Some contraindications associated with norepinephrine usage are myocardial ischemia, premature ventricular contractions (PVCs), and ventricular tachycardia.


Epinephrine, a potent α and β adrenergic agonist, is used for treating bronchoconstriction and hypotension resulting from anaphylaxis as well as all forms of cardiac arrest. Injection of epinephrine leads to an increase in systolic pressure, ventricular contractility, and heart rate. Some side effects associated with epinephrine usage are cardiac arrhythmias, particularly PVCs, ventricular tachycardia, renal vascular ischemia, increased myocardial oxygen requirements, and hypokalemia.


Anthracyclines are antineoplastic agents used commonly for the treatment of breast cancer, leukemias, and a variety of other solid tumors. However, the usefulness of the drugs are limited due dose-dependent cardiomyopathy and ECG changes (Casarett & Doull's Toxicology, The Basic Science of Poisons 6th ed., p. 619, C. D. Klaassen, Ed., McGraw Hill, New York, 2001).


Adriamycin (doxorubicin) is a cytotoxic anthracycline antiobiotic that inhibits the action of topoisomerase II. It has a wide spectrum of antitumor activity, however dose-related cardiotoxicity is a major side effect. The toxic effects are most likely due to the generation of free radicals (DeAtley et al. (1999), Toxicology 134: 51-62). In one study, rats were given a dose of either adriamycin alone or a dose of adriamycin following a dose of captopril (al-Shabanah et al. (1998), Biochem Mol Biol Int 45: 419-427). Those rats that were only given adriamycin developed myocardial toxicity after 24 hours manifested biochemically by an elevation of serum enzymes such as aspartate transaminase, lactate dehydrogenase, and creatine phosphokinase. The rats that were pre-treated with captopril exhibited a significant reduction in serum enzyme levels as well as restoration of white blood cell counts.


Epirubicin is a semisynthetic derivative of daunorubicin, an anthracycline, approved for the treatment of breast cancer (Casarett & Doull's Toxicology The Basic Science of Poisons 6th ed., p. 619, C. D. Klaassen, Ed., McGraw Hill, New York, 2001). Yet, it, too, may induce cardiotoxicity. In one observational study, 120 patients with advanced breast cancer were followed before, during, and after treatment with epirubicin (Jensen et al. (2002), Ann Oncol 13: 699-709). Approximately 59% of the patients experienced a 25% relative reduction in left ventricular ejection fraction three years after epirubicin treatment, and of these patients 20% had deteriorated into having congestive heart failure.


Amphotericin B is a polyene, antifungal antibiotic used to treat fungal infections. Its clinical utility is limited by its nephrotoxicity and cardiotoxicity. Amphotericin B may depress myocardial contractility by blocking activation of slow calcium channels and inhibiting the influx of sodium ions (Casarett & Doull's Toxicology The Basic Science of Poisons 6th ed., p. 621, C. D. Klaassen, Ed., McGraw Hill, New York, 2001). It has been shown to increase the permeability of the sarcolemmal membrane, and patients given amphotericin B have developed ventricular tachycardia and cardiac arrest. This drug has been shown to induce cardiac arrest in rats as well. In the current study, amphotericin B led to an increase in serum Troponin T levels and some early signs of cardiomyopathy within 24 hours of one intravenous bolus injection.


Phenylpropanolamine was used in over-the-counter decongestants until recently, but was withdrawn when its association with cardiac deaths became known. It is both a beta-1 and alpha adrenergic receptor agonist and has been shown to induce cardiotoxicity in rats. In one rat study, phenylpropanolamine was shown to cause myocardial contractile depression without altering global coronary artery blood flow (Zaloga et al. (2000), Crit Care Med 28: 3679-3683).


In another study, rats were given single intraperitoneal doses of 1, 2, 4, 8, 16, or 32 mg/kg of phenylpropanolamine (Pentel et al. (1987), Fundam Appl Toxicol 9: 167-172). The animals exhibited dose-dependent increased blood pressure and, following termination, myocardial necrosis.


Rosiglitazone (Avandia) is a thiazolidinedione medication used to treat Type 2 diabetes. It reduces plasma glucose levels and glucose production and increases glucose clearance (Wagstaff and Goa (2002), Drugs 62: 1805-1837). Some side effects associated with rosiglitazone treatment are fluid retention, congestive heart failure, and liver disease. In patients who have heart failure or use insulin, there is a potential for mild-to-moderate peripheral edema with rosiglitazone treatment. It has been shown that patients that do not have heart failure or use insulin can also develop moderate-to-severe edema while using rosiglitazone (Niemeyer and Janney (2002), Pharmacotherapy 22: 924-929).


Toxicity Prediction and Modeling


The genes and gene expression information, gene expression profiles, as well as the portfolios and subsets of the genes provided in Tables 1-5LL, such as the core toxicity markers in Tables 5A-5LL, may be used to predict at least one toxic effect, including the cardiotoxicity of a test or unknown compound. As used herein, at least one toxic effect includes, but is not limited to, a detrimental change in the physiological status of a cell or organism. The response may be, but is not required to be, associated with a particular pathology, such as tissue necrosis, myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, and cardiogenic shock. Accordingly, the toxic effect includes effects at the molecular and cellular level. Cardiotoxicity is an effect as used herein and includes but is not limited to the pathologies of tissue necrosis, myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, and cardiogenic shock. As used herein, a gene expression profile comprises any representation, quantitative or not, of the expression of at least one mRNA species in a cell sample or population and includes profiles made by various methods such as differential display, PCR, hybridization analysis, etc.


In general, assays to predict the toxicity or cardiotoxicity of a test agent (or compound or multi-component composition) comprise the steps of exposing a cell population to the test compound, assaying or measuring the level of relative or absolute gene expression of one or more of the genes in Tables 1-5LL and comparing the identified expression level(s) to the expression levels disclosed in the Tables and database(s) disclosed herein. Assays may include the measurement of the expression levels of about 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 50, 75, 100 or more genes from Tables 1-5LL to create multi-gene expression profiles.


In the methods of the invention, the gene expression level for a gene or genes induced by the test agent, compound or compositions may be comparable to the levels found in the Tables or databases disclosed herein if the expression level varies within a factor of about 2, about 1.5 or about 1.0 fold. In some cases, the expression levels are comparable if the agent induces a change in the expression of a gene in the same direction (e.g., up or down) as a reference toxin.


The cell population that is exposed to the test agent, compound or composition may be exposed in vitro or in vivo. For instance, cultured or freshly isolated heart cells, in particular rat heart cells, may be exposed to the agent under standard laboratory and cell culture conditions. In another assay format, in vivo exposure may be accomplished by administration of the agent to a living animal, for instance a laboratory rat.


Procedures for designing and conducting toxicity tests in in vitro and in vivo systems are well known, and are described in many texts on the subject, such as Loomis et al., Loomis's Essentials of Toxicology 4th Ed., Academic Press, New York, 1996; Echobichon, The Basics of Toxicity Testing, CRC Press, Boca Raton, 1992; Frazier, editor, In Vitro Toxicity Testing, Marcel Dekker, New York, 1992; and the like.


In in vitro toxicity testing, two groups of test organisms are usually employed: one group serves as a control and the other group receives the test compound in a single dose (for acute toxicity tests) or a regimen of doses (for prolonged or chronic toxicity tests). Because, in some cases, the extraction of tissue as called for in the methods of the invention requires sacrificing the test animal, both the control group and the group receiving compound must be large enough to permit removal of animals for sampling tissues, if it is desired to observe the dynamics of gene expression through the duration of an experiment.


In setting up a toxicity study, extensive guidance is provided in the literature for selecting the appropriate test organism for the compound being tested, route of administration, dose ranges, and the like. Water or physiological saline (0.9% NaCl in water) is the solute of choice for the test compound since these solvents permit administration by a variety of routes. When this is not possible because of solubility limitations, vegetable oils such as corn oil or organic solvents such as propylene glycol may be used.


Regardless of the route of administration, the volume required to administer a given dose is limited by the size of the animal that is used. It is desirable to keep the volume of each dose uniform within and between groups of animals. When rats or mice are used, the volume administered by the oral route generally should not exceed about 0.005 ml per gram of animal. Even when aqueous or physiological saline solutions are used for parenteral injection, the volumes that are tolerated are limited, although such solutions are ordinarily thought of as being innocuous. The intravenous LD50 of distilled water in the mouse is approximately 0.044 ml per gram and that of isotonic saline is 0.068 ml per gram of mouse. In some instances, the route of administration to the test animal should be the same as, or as similar as possible to, the route of administration of the compound to man for therapeutic purposes.


When a compound is to be administered by inhalation, special techniques for generating test atmospheres are necessary. The methods usually involve aerosolization or nebulization of fluids containing the compound. If the agent to be tested is a fluid that has an appreciable vapor pressure, it may be administered by passing air through the solution under controlled temperature conditions. Under these conditions, dose is estimated from the volume of air inhaled per unit time, the temperature of the solution, and the vapor pressure of the agent involved. Gases are metered from reservoirs. When particles of a solution are to be administered, unless the particle size is less than about 2 μm the particles will not reach the terminal alveolar sacs in the lungs. A variety of apparatuses and chambers are available to perform studies for detecting effects of irritant or other toxic endpoints when they are administered by inhalation. The preferred method of administering an agent to animals is via the oral route, either by intubation or by incorporating the agent in the feed.


When the agent is exposed to cells in vitro or in cell culture, the cell population to be exposed to the agent may be divided into two or more subpopulations, for instance, by dividing the population into two or more identical aliquots. In some preferred embodiments of the methods of the invention, the cells to be exposed to the agent are derived from heart tissue. For instance, cultured or freshly isolated rat heart cells may be used.


The methods of the invention may be used generally to predict at least one toxic response, and, as described in the Examples, may be used to predict the likelihood that a compound or test agent will induce various specific heart pathologies, such as tissue necrosis, myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, cardiogenic shock, or other pathologies associated with at least one of the toxins herein described. The methods of the invention may also be used to determine the similarity of a toxic response to one or more individual compounds. In addition, the methods of the invention may be used to predict or elucidate the potential cellular pathways influenced, induced or modulated by the compound or test agent due to the similarity of the expression profile compared to the profile induced by a known toxin (see Tables 5-5LL).


Diagnostic Uses for the Toxicity Markers


As described above, the genes and gene expression information or portfolios of the genes with their expression information as provided in Tables 1-5LL may be used as diagnostic markers for the prediction or identification of the physiological state of a tissue or cell sample that has been exposed to a compound or to identify or predict the toxic effects of a compound or agent. For instance, a tissue sample such as a sample of peripheral blood cells or some other easily obtainable tissue sample may be assayed by any of the methods described above, and the expression levels from a gene or genes from Tables 5-5LL may be compared to the expression levels found in tissues or cells exposed to the toxins described herein. These methods may result in the diagnosis of a physiological state in the cell, may be used to diagnose toxin exposure or may be used to identify the potential toxicity of a compound, for instance a new or unknown compound or agent that the subject has been exposed to. The comparison of expression data, as well as available sequence or other information may be done by researcher or diagnostician or may be done with the aid of a computer and databases as described below.


In another format, the levels of a gene(s) of Tables 5-5LL, its encoded protein(s), or any metabolite produced by the encoded protein may be monitored or detected in a sample, such as a bodily tissue or fluid sample to identify or diagnose a physiological state of an organism. Such samples may include any tissue or fluid sample, including urine, blood and easily obtainable cells such as peripheral lymphocytes.


Use of the Markers for Monitoring Toxicity Progression


As described above, the genes and gene expression information provided in Tables 5-5LL may also be used as markers for the monitoring of toxicity progression, such as that found after initial exposure to a drug, drug candidate, toxin, pollutant, etc. For instance, a tissue or cell sample may be assayed by any of the methods described above, and the expression levels from a gene or genes from Tables 5-5LL may be compared to the expression levels found in tissue or cells exposed to the cardiotoxins described herein. The comparison of the expression data, as well as available sequence or other information may be done by a researcher or diagnostician or may be done with the aid of a computer and databases.


Use of the Toxicity Markers for Drug Screening


According to the present invention, the genes identified in Tables 1-5LL may be used as markers or drug targets to evaluate the effects of a candidate drug, chemical compound or other agent on a cell or tissue sample. The genes may also be used as drug targets to screen for agents that modulate their expression and/or activity. In various formats, a candidate drug or agent can be screened for the ability to stimulate the transcription or expression of a given marker or markers or to down-regulate or counteract the transcription or expression of a marker or markers. According to the present invention, one can also compare the specificity of a drug's effects by looking at the number of markers which the drug induces and comparing them. More specific drugs will have less transcriptional targets. Similar sets of markers identified for two drugs may indicate a similarity of effects.


Assays to monitor the expression of a marker or markers as defined in Tables 1-5LL may utilize any available means of monitoring for changes in the expression level of the nucleic acids of the invention. As used herein, an agent is said to modulate the expression of a nucleic acid of the invention if it is capable of up- or down-regulating expression of the nucleic acid in a cell.


In one assay format, gene chips containing probes to one, two or more genes from Tables 1-5LL may be used to directly monitor or detect changes in gene expression in the treated or exposed cell. Cell lines, tissues or other samples are first exposed to a test agent and in some instances, a known toxin, and the detected expression levels of one or more, or preferably 2 or more of the genes of Tables 1-5LL are compared to the expression levels of those same genes exposed to a known toxin alone. Compounds that modulate the expression patterns of the known toxin(s) would be expected to modulate potential toxic physiological effects in vivo. The genes in Tables 1-5LL are particularly appropriate markers in these assays as they are differentially expressed in cells upon exposure to a known cardiotoxin. Tables 1 and 2 disclose those genes that are differentially expressed upon exposure to the named toxins and their corresponding GenBank Accession numbers. Table 3 discloses the human homologues and the corresponding GenBank Accession numbers of the differentially expressed genes of Tables 1 and 2.


In another format, cell lines that contain reporter gene fusions between the open reading frame and/or the transcriptional regulatory regions of a gene in Tables 1-5LL and any assayable fusion partner may be prepared. Numerous assayable fusion partners are known and readily available including the firefly luciferase gene and the gene encoding chloramphenicol acetyltransferase (Alam et al. (1990), Anal Biochem 188: 245-254). Cell lines containing the reporter gene fusions are then exposed to the agent to be tested under appropriate conditions and time. Differential expression of the reporter gene between samples exposed to the agent and control samples identifies agents which modulate the expression of the nucleic acid.


Additional assay formats may be used to monitor the ability of the agent to modulate the expression of a gene identified in Tables 5-5LL. For instance, as described above, mRNA expression may be monitored directly by hybridization of probes to the nucleic acids of the invention. Cell lines are exposed to the agent to be tested under appropriate conditions and time, and total RNA or mRNA is isolated by standard procedures such those disclosed in Sambrook et al. (Molecular Cloning: A Laboratory Manual. 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989).


In another assay format, cells or cell lines are first identified which express the gene products of the invention physiologically. Cells and/or cell lines so identified would be expected to comprise the necessary cellular machinery such that the fidelity of modulation of the transcriptional apparatus is maintained with regard to exogenous contact of agent with appropriate surface transduction mechanisms and/or the cytosolic cascades. Further, such cells or cell lines may be transduced or transfected with an expression vehicle (e.g., a plasmid or viral vector) construct comprising an operable non-translated 5′-promoter containing end of the structural gene encoding the gene products of Tables 1-5LL fused to one or more antigenic fragments or other detectable markers, which are peculiar to the instant gene products, wherein said fragments are under the transcriptional control of said promoter and are expressed as polypeptides whose molecular weight can be distinguished from the naturally occurring polypeptides or may further comprise an immunologically distinct or other detectable tag. Such a process is well known in the art (see Sambrook et al., supra).


Cells or cell lines transduced or transfected as outlined above are then contacted with agents under appropriate conditions; for example, the agent comprises a pharmaceutically acceptable excipient and is contacted with cells comprised in an aqueous physiological buffer such as phosphate buffered saline (PBS) at physiological pH, Eagles balanced salt solution (BSS) at physiological pH, PBS or BSS comprising serum or conditioned media comprising PBS or BSS and/or serum incubated at 37° C. Said conditions may be modulated as deemed necessary by one of skill in the art. Subsequent to contacting the cells with the agent, said cells are disrupted and the polypeptides of the lysate are fractionated such that a polypeptide fraction is pooled and contacted with an antibody to be further processed by immunological assay (e.g., ELISA, immunoprecipitation or Western blot). The pool of proteins isolated from the “agent-contacted” sample is then compared with the control samples (no exposure and exposure to a known toxin) where only the excipient is contacted with the cells and an increase or decrease in the immunologically generated signal from the “agent-contacted” sample compared to the control is used to distinguish the effectiveness and/or toxic effects of the agent.


Use of Toxicity Markers to Identify Agents that Modulate Protein Activity or Levels


Another embodiment of the present invention provides methods for identifying agents that modulate at least one activity of a protein(s) encoded by the genes in Tables 1-5LL. Such methods or assays may utilize any means of monitoring or detecting the desired activity.


In one format, the relative amounts of a protein (Tables 1-5LL) between a cell population that has been exposed to the agent to be tested compared to an unexposed control cell population and a cell population exposed to a known toxin may be assayed. In this format, probes such as specific antibodies are used to monitor the differential expression of the protein in the different cell populations. Cell lines or populations are exposed to the agent to be tested under appropriate conditions and time. Cellular lysates may be prepared from the exposed cell line or population and a control, unexposed cell line or population. The cellular lysates are then analyzed with the probe, such as a specific antibody.


Agents that are assayed in the above methods can be randomly selected or rationally selected or designed. As used herein, an agent is said to be randomly selected when the agent is chosen randomly without considering the specific sequences involved in the association of a protein of the invention alone or with its associated substrates, binding partners, etc. An example of randomly selected agents is the use a chemical library or a peptide combinatorial library, or a growth broth of an organism.


As used herein, an agent is said to be rationally selected or designed when the agent is chosen on a nonrandom basis which takes into account the sequence of the target site and/or its conformation in connection with the agent's action. Agents can be rationally selected or rationally designed by utilizing the peptide sequences that make up these sites. For example, a rationally selected peptide agent can be a peptide whose amino acid sequence is identical to or a derivative of any functional consensus site.


The agents of the present invention can be, as examples, peptides, small molecules, vitamin derivatives, as well as carbohydrates. Dominant negative proteins, DNAs encoding these proteins, antibodies to these proteins, peptide fragments of these proteins or mimics of these proteins may be introduced into cells to affect function. “Mimic” as used herein refers to the modification of a region or several regions of a peptide molecule to provide a structure chemically different from the parent peptide but topographically and functionally similar to the parent peptide (see G. A. Grant in: Molecular Biology and Biotechnology, Meyers, ed., pp. 659-664, VCH Publishers, New York, 1995). A skilled artisan can readily recognize that there is no limit as to the structural nature of the agents of the present invention.


Nucleic Acid Assay Formats


As previously discussed, the genes identified as being differentially expressed upon exposure to a known cardiotoxin (Tables 1-5LL) may be used in a variety of nucleic acid detection assays to detect or quantify the expression level of a gene or multiple genes in a given sample. The genes described in Tables 1-5LL may also be used in combination with one or more additional genes whose differential expression is associate with toxicity in a cell or tissue. In preferred embodiments, the genes in Tables 5-5LL may be combined with one or more of the genes described in prior and related application No. 60/303,819 filed on Jul. 10, 2001; No. 60/305,623 filed on Jul. 17, 2001; No. 60/369,351 filed on Apr. 3, 2002; and No. 60/377,611 filed on May 6, 2002; Ser. Nos. 09/917,800; 10/060,087; 10/152,319; 10/191,803, and 10/______, entitled “Molecular Nephrotoxicology Modeling” (Attorney Docket No. 044921-5089-01-US) filed on Nov. 22, 2002, all of which are incorporated by reference.


Any assay format to detect gene expression may be used. For example, traditional Northern blotting, dot or slot blot, nuclease protection, primer directed amplification, RT-PCR, semi- or quantitative PCR, branched-chain DNA and differential display methods may be used for detecting gene expression levels. Those methods are useful for some embodiments of the invention. In cases where smaller numbers of genes are detected, amplification based assays may be most efficient. Methods and assays of the invention, however, may be most efficiently designed with hybridization-based methods for detecting the expression of a large number of genes.


Any hybridization assay format may be used, including solution-based and solid support-based assay formats. Solid supports containing oligonucleotide probes for differentially expressed genes of the invention can be filters, polyvinyl chloride dishes, particles, beads, microparticles or silicon or glass based chips, etc. Such chips, wafers and hybridization methods are widely available, for example, those disclosed by Beattie (WO 95/11755).


Any solid surface to which oligonucleotides can be bound, either directly or indirectly, either covalently or non-covalently, can be used. A preferred solid support is a high density array or DNA chip. These contain a particular oligonucleotide probe in a predetermined location on the array. Each predetermined location may contain more than one molecule of the probe, but each molecule within the predetermined location has an identical sequence. Such predetermined locations are termed features. There may be, for example, from 2, 10, 100, 1000 to 10,000, 100,000, 400,000 or 1,000,000 or more of such features on a single solid support. The solid support, or the area within which the probes are attached may be on the order of about a square centimeter. Probes corresponding to the genes of Tables 5-5LL or from the related applications described above may be attached to single or multiple solid support structures, e.g., the probes may be attached to a single chip or to multiple chips to comprise a chip set.


Oligonucleotide probe arrays for expression monitoring can be made and used according to any techniques known in the art (see for example, Lockhart et al. (1996), Nat Biotechnol 14: 1675-1680; McGall et al. (1996), Proc Nat Acad Sci USA 93: 13555-13460). Such probe arrays may contain at least two or more oligonucleotides that are complementary to or hybridize to two or more of the genes described in Tables 5-5LL. For instance, such arrays may contain oligonucleotides that are complementary to or hybridize to at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 50, 70, 100 or more of the genes described herein. Preferred arrays contain all or nearly all of the genes listed in Tables 1-5LL, or individually, the gene sets of Tables 5-5LL. In a preferred embodiment, arrays are constructed that contain oligonucleotides to detect all or nearly all of the genes in any one of or all of Tables 1-5LL on a single solid support substrate, such as a chip.


The sequences of the expression marker genes of Tables 1-5LL are in the public databases. Table 1 provides the GenBank Accession Number for each of the sequences (see www.nebi.nlm.nih.gov/) as well as a corresponding SEQ ID NO. in the sequence listing filed with this application. Table 3 provides the LocusLink and Unigene names and descriptions for the human homologues of the genes described in Tables 1 and 2. The sequences of the genes in GenBank and/or RefSeq are expressly herein incorporated by reference in their entirety as of the filing date of this application, as are related sequences, for instance, sequences from the same gene of different lengths, variant sequences, polymorphic sequences, genomic sequences of the genes and related sequences from different species, including the human counterparts, where appropriate (see Table 3). These sequences may be used in the methods of the invention or may be used to produce the probes and arrays of the invention. In some embodiments, the genes in Tables 1-5LL that correspond to the genes or fragments previously associated with a toxic response may be excluded from the Tables.


As described above, in addition to the sequences of the GenBank Accession Numbers disclosed in the Tables 1-5LL, sequences such as naturally occurring variants or polymorphic sequences may be used in the methods and compositions of the invention. For instance, expression levels of various allelic or homologous forms of a gene disclosed in Tables 1-5LL may be assayed. Any and all nucleotide variations that do not significantly alter the functional activity of a gene listed in the Tables 1-5LL, including all naturally occurring allelic variants of the genes herein disclosed, may be used in the methods and to make the compositions (e.g., arrays) of the invention.


Probes based on the sequences of the genes described above may be prepared by any commonly available method. Oligonucleotide probes for screening or assaying a tissue or cell sample are preferably of sufficient length to specifically hybridize only to appropriate, complementary genes or transcripts. Typically the oligonucleotide probes will be at least about 10, 12, 14, 16, 18, 20 or 25 nucleotides in length. In some cases, longer probes of at least 30, 40, or 50 nucleotides will be desirable.


As used herein, oligonucleotide sequences that are complementary to one or more of the genes described in Tables 1-5LL refer to oligonucleotides that are capable of hybridizing under stringent conditions to at least part of the nucleotide sequences of said genes, their encoded RNA or mRNA, or amplified versions of the RNA such as cRNA. Such hybridizable oligonucleotides will typically exhibit at least about 75% sequence identity at the nucleotide level to said genes, preferably about 80% or 85% sequence identity or more preferably about 90% or 95% or more sequence identity to said genes.


“Bind(s) substantially” refers to complementary hybridization between a probe nucleic acid and a target nucleic acid and embraces minor mismatches that can be accommodated by reducing the stringency of the hybridization media to achieve the desired detection of the target polynucleotide sequence.


The terms “background” or “background signal intensity” refer to hybridization signals resulting from non-specific binding, or other interactions, between the labeled target nucleic acids and components of the oligonucleotide array (e.g., the oligonucleotide probes, control probes, the array substrate, etc.). Background signals may also be produced by intrinsic fluorescence of the array components themselves. A single background signal can be calculated for the entire array, or a different background signal may be calculated for each target nucleic acid. In a preferred embodiment, background is calculated as the average hybridization signal intensity for the lowest 5% to 10% of the probes in the array, or, where a different background signal is calculated for each target gene, for the lowest 5% to 10% of the probes for each gene. Of course, one of skill in the art will appreciate that where the probes to a particular gene hybridize well and thus appear to be specifically binding to a target sequence, they should not be used in a background signal calculation. Alternatively, background may be calculated as the average hybridization signal intensity produced by hybridization to probes that are not complementary to any sequence found in the sample (e.g. probes directed to nucleic acids of the opposite sense or to genes not found in the sample such as bacterial genes where the sample is mammalian nucleic acids). Background can also be calculated as the average signal intensity produced by regions of the array that lack any probes at all.


The phrase “hybridizing specifically to” or “specifically hybridizes” refers to the binding, duplexing, or hybridizing of a molecule substantially to or only to a particular nucleotide sequence or sequences under stringent conditions when that sequence is present in a complex mixture (e.g., total cellular) DNA or RNA.


Assays and methods of the invention may utilize available formats to simultaneously screen at least about 100, preferably about 1000, more preferably about 10,000 and most preferably about 100,000 or 1,000,000 or more different nucleic acid hybridizations.


As used herein a “probe” is defined as a nucleic acid, capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (i.e., A, G, U, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in probes may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. Thus, probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages.


The term “perfect match probe” refers to a probe that has a sequence that is perfectly complementary to a particular target sequence. The test probe is typically perfectly complementary to a portion (subsequence) of the target sequence. The perfect match (PM) probe can be a “test probe”, a “normalization control” probe, an expression level control probe and the like. A perfect match control or perfect match probe is, however, distinguished from a “mismatch control” or “mismatch probe.”


The terms “mismatch control” or “mismatch probe” refer to a probe whose sequence is deliberately selected not to be perfectly complementary to a particular target sequence. For each mismatch (MM) control in a high-density array there typically exists a corresponding perfect match (PM) probe that is perfectly complementary to the same particular target sequence. The mismatch may comprise one or more bases.


While the mismatch(es) may be located anywhere in the mismatch probe, terminal mismatches are less desirable as a terminal mismatch is less likely to prevent hybridization of the target sequence. In a particularly preferred embodiment, the mismatch is located at or near the center of the probe such that the mismatch is most likely to destabilize the duplex with the target sequence under the test hybridization conditions.


The term “stringent conditions” refers to conditions under which a probe will hybridize to its target subsequence, but with only insubstantial hybridization to other sequences or to other sequences such that the difference may be identified. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. Generally, stringent conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH.


Typically, stringent conditions will be those in which the salt concentration is at least about 0.01 to 1.0 M Na+ ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.


The “percentage of sequence identity” or “sequence identity” is determined by comparing two optimally aligned sequences or subsequences over a comparison window or span, wherein the portion of the polynucleotide sequence in the comparison window may optionally comprise additions or deletions (i.e., gaps) as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical submit (e.g. nucleic acid base or amino acid residue) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison and multiplying the result by 100 to yield the percentage of sequence identity. Percentage sequence identity when calculated using the programs GAP or BESTFIT (see below) is calculated using default gap weights.


Probe Design


One of skill in the art will appreciate that an enormous number of array designs are suitable for the practice of this invention. The high density array will typically include a number of test probes that specifically hybridize to the sequences of interest. Probes may be produced from any region of the genes identified in the Tables and the attached representative sequence listing. In instances where the gene reference in the Tables is an EST, probes may be designed from that sequence or from other regions of the corresponding full-length transcript that may be available in any of the sequence databases, such as those herein described. See WO 99/32660 for methods of producing probes for a given gene or genes. In addition, any available software may be used to produce specific probe sequences, including, for instance, software available from Molecular Biology Insights, Olympus Optical Co. and Biosoft International. In a preferred embodiment, the array will also include one or more control probes.


High density array chips of the invention include “test probes.” Test probes may be oligonucleotides that range from about 5 to about 500, or about 7 to about 50 nucleotides, more preferably from about 10 to about 40 nucleotides and most preferably from about 15 to about 35 nucleotides in length. In other particularly preferred embodiments, the probes are 20 or 25 nucleotides in length. In another preferred embodiment, test probes are double or single strand DNA sequences such as cDNA fragments. DNA sequences are isolated or cloned from natural sources or amplified from natural sources using native nucleic acid as templates. These probes have sequences complementary to particular subsequences of the genes whose expression they are designed to detect. Thus, the test probes are capable of specifically hybridizing to the target nucleic acid they are to detect.


In addition to test probes that bind the target nucleic acid(s) of interest, the high density array can contain a number of control probes. The control probes may fall into three categories referred to herein as 1) normalization controls; 2) expression level controls; and 3) mismatch controls.


Normalization controls are oligonucleotide or other nucleic acid probes that are complementary to labeled reference oligonucleotides or other nucleic acid sequences that are added to the nucleic acid sample to be screened. The signals obtained from the normalization controls after hybridization provide a control for variations in hybridization conditions, label intensity, “reading” efficiency and other factors that may cause the signal of a perfect hybridization to vary between arrays. In a preferred embodiment, signals (e.g., fluorescence intensity) read from all other probes in the array are divided by the signal (e.g., fluorescence intensity) from the control probes thereby normalizing the measurements.


Virtually any probe may serve as a normalization control. However, it is recognized that hybridization efficiency varies with base composition and probe length. Preferred normalization probes are selected to reflect the average length of the other probes present in the array, however, they can be selected to cover a range of lengths. The normalization control(s) can also be selected to reflect the (average) base composition of the other probes in the array, however in a preferred embodiment, only one or a few probes are used and they are selected such that they hybridize well (i.e., no secondary structure) and do not match any target-specific probes.


Expression level controls are probes that hybridize specifically with constitutively expressed genes in the biological sample. Virtually any constitutively expressed gene provides a suitable target for expression level controls. Typically expression level control probes have sequences complementary to subsequences of constitutively expressed “housekeeping genes” including, but not limited to the actin gene, the transferrin receptor gene, the GAPDH gene, and the like.


Mismatch controls may also be provided for the probes to the target genes, for expression level controls or for normalization controls. Mismatch controls are oligonucleotide probes or other nucleic acid probes identical to their corresponding test or control probes except for the presence of one or more mismatched bases. A mismatched base is a base selected so that it is not complementary to the corresponding base in the target sequence to which the probe would otherwise specifically hybridize. One or more mismatches are selected such that under appropriate hybridization conditions (e.g., stringent conditions) the test or control probe would be expected to hybridize with its target sequence, but the mismatch probe would not hybridize (or would hybridize to a significantly lesser extent). Preferred mismatch probes contain a central mismatch. Thus, for example, where a probe is a 20 mer, a corresponding mismatch probe will have the identical sequence except for a single base mismatch (e.g., substituting a G, a C or a T for an A) at any of positions 6 through 14 (the central mismatch).


Mismatch probes thus provide a control for non-specific binding or cross hybridization to a nucleic acid in the sample other than the target to which the probe is directed. For example, if the target is present the perfect match probes should be consistently brighter than the mismatch probes. In addition, if all central mismatches are present, the mismatch probes can be used to detect a mutation, for instance, a mutation of a gene in the accompanying Tables 1-5LL. The difference in intensity between the perfect match and the mismatch probe provides a good measure of the concentration of the hybridized material.


Nucleic Acid Samples


Cell or tissue samples may be exposed to the test agent in vitro or in vivo. When cultured cells or tissues are used, appropriate mammalian cell extracts, such as liver cell extracts, may also be added with the test agent to evaluate agents that may require biotransformation to exhibit toxicity.


The genes which are assayed according to the present invention are typically in the form of mRNA or reverse transcribed mRNA. The genes may or may not be cloned. The genes may or may not be amplified and cRNA produced. The cloning and/or amplification do not appear to bias the representation of genes within a population. In some assays, it may be preferable, however, to use polyA+ RNA as a source, as it can be used with less processing steps.


As is apparent to one of ordinary skill in the art, nucleic acid samples used in the methods and assays of the invention may be prepared by any available method or process. Methods of isolating total mRNA are well known to those of skill in the art. For example, methods of isolation and purification of nucleic acids are described in detail in Chapter 3 of Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 24, Hybridization With Nucleic Acid Probes: Theory and Nucleic Acid Probes, P. Tijssen, Ed., Elsevier Press, New York, 1993. Such samples include RNA samples, but also include cDNA synthesized from a mRNA sample isolated from a cell or tissue of interest. Such samples also include DNA amplified from the cDNA, and RNA transcribed from the amplified DNA (cRNA). One of skill in the art would appreciate that it is desirable to inhibit or destroy RNase present in homogenates before homogenates are used.


Biological samples may be of any biological tissue or fluid or cells from any organism as well as cells raised in vitro, such as cell lines and tissue culture cells. Frequently the sample will be a tissue or cell sample that has been exposed to a compound, agent, drug, pharmaceutical composition, potential environmental pollutant or other composition. In some formats, the sample will be a “clinical sample” which is a sample derived from a patient. Typical clinical samples include, but are not limited to, sputum, blood, blood-cells (e.g., white cells), tissue or fine needle biopsy samples, urine, peritoneal fluid, and pleural fluid, or cells therefrom. Biological samples may also include sections of tissues, such as frozen sections or formalin fixed sections taken for histological purposes.


Forming High Density Arrays


Methods of forming high density arrays of oligonucleotides with a minimal number of synthetic steps are known. The oligonucleotide analogue array can be synthesized on a single or on multiple solid substrates by a variety of methods, including, but not limited to, light-directed chemical coupling, and mechanically directed coupling (see Pirrung, U.S. Pat. No. 5,143,854).


In brief, the light-directed combinatorial synthesis of oligonucleotide arrays on a glass surface proceeds using automated phosphoramidite chemistry and chip masking techniques. In one specific implementation, a glass surface is derivatized with a silane reagent containing a functional group, e.g., a hydroxyl or amine group blocked by a photolabile protecting group. Photolysis through a photolithographic mask is used selectively to expose functional groups which are then ready to react with incoming 5′ photoprotected nucleoside phosphoramidites. The phosphoramidites react only with those sites which are illuminated (and thus exposed by removal of the photolabile blocking group). Thus, the phosphoramidites only add to those areas selectively exposed from the preceding step. These steps are repeated until the desired array of sequences have been synthesized on the solid surface. Combinatorial synthesis of different oligonucleotide analogues at different locations on the array is determined by the pattern of illumination during synthesis and the order of addition of coupling reagents.


In addition to the foregoing, additional methods which can be used to generate an array of oligonucleotides on a single substrate are described in PCT Publication Nos. WO 93/09668 and WO 01/23614. High density nucleic acid arrays can also be fabricated by depositing pre-made or natural nucleic acids in predetermined positions. Synthesized or natural nucleic acids are deposited on specific locations of a substrate by light directed targeting and oligonucleotide directed targeting. Another embodiment uses a dispenser that moves from region to region to deposit nucleic acids in specific spots.


Hybridization


Nucleic acid hybridization simply involves contacting a probe and target nucleic acid under conditions where the probe and its complementary target can form stable hybrid duplexes through complementary base pairing. See WO 99/32660. The nucleic acids that do not form hybrid duplexes are then washed away leaving the hybridized nucleic acids to be detected, typically through detection of an attached detectable label. It is generally recognized that nucleic acids are denatured by increasing the temperature or decreasing the salt concentration of the buffer containing the nucleic acids. Under low stringency conditions (e.g., low temperature and/or high salt) hybrid duplexes (e.g., DNA:DNA, RNA:RNA, or RNA:DNA) will form even where the annealed sequences are not perfectly complementary. Thus, specificity of hybridization is reduced at lower stringency. Conversely, at higher stringency (e.g., higher temperature or lower salt) successful hybridization tolerates fewer mismatches. One of skill in the art will appreciate that hybridization conditions may be selected to provide any degree of stringency.


In a preferred embodiment, hybridization is performed at low stringency, in this case in 6×SSPET at 37° C. (0.005% Triton X-100), to ensure hybridization and then subsequent washes are performed at higher stringency (e.g., 1×SSPET at 37° C.) to eliminate mismatched hybrid duplexes. Successive washes may be performed at increasingly higher stringency (e.g., down to as low as 0.25×SSPET at 37° C. to 50° C.) until a desired level of hybridization specificity is obtained. Stringency can also be increased by addition of agents such as formamide. Hybridization specificity may be evaluated by comparison of hybridization to the test probes with hybridization to the various controls that can be present (e.g., expression level control, normalization control, mismatch controls, etc.).


In general, there is a tradeoff between hybridization specificity (stringency) and signal intensity. Thus, in a preferred embodiment, the wash is performed at the highest stringency that produces consistent results and that provides a signal intensity greater than approximately 10% of the background intensity. Thus, in a preferred embodiment, the hybridized array may be washed at successively higher stringency solutions and read between each wash. Analysis of the data sets thus produced will reveal a wash stringency above which the hybridization pattern is not appreciably altered and which provides adequate signal for the particular oligonucleotide probes of interest.


Signal Detection


The hybridized nucleic acids are typically detected by detecting one or more labels attached to the sample nucleic acids. The labels may be incorporated by any of a number of means well known to those of skill in the art. See WO 99/32660.


Databases


The present invention includes relational databases containing sequence information, for instance, for the genes of Tables 1-5LL, as well as gene expression information from tissue or cells exposed to various standard toxins, such as those herein described (see Tables 5-5LL). Databases may also contain information associated with a given sequence or tissue sample such as descriptive information about the gene associated with the sequence information (see Tables 1 and 2), or descriptive information concerning the clinical status of the tissue sample, or the animal from which the sample was derived. The database may be designed to include different parts, for instance a sequence database and a gene expression database. Methods for the configuration and construction of such databases and computer-readable media to which such databases are saved are widely available, for instance, see U.S. Pat. No. 5,953,727, which is herein incorporated by reference in its entirety.


The databases of the invention may be linked to an outside or external database such as GenBank (www.ncbi.nlm.nih.gov/entrez.index.html); KEGG (www.genome.ad.jp/kegg); SPAD (www.grt.kyushu-u.ac.jp/spad/index.html); HUGO (www.gene.ucl.ac.uk/hugo); Swiss-Prot (www.expasy.ch.sprot); Prosite (www.expasy.ch/tools/scnpsit1.html); OMIM (www.ncbi.nlm.nih.gov/omim); and GDB (www.gdb.org). In a preferred embodiment, as described in Tables 1-3, the external database is GenBank and the associated databases maintained by the National Center for Biotechnology Information (NCBI) (www.nebi.nlm.nih.gov).


Any appropriate computer platform, user interface, etc. may be used to perform the necessary comparisons between sequence information, gene expression information and any other information in the database or information provided as an input. For example, a large number of computer workstations are available from a variety of manufacturers, such has those available from Silicon Graphics. Client/server environments, database servers and networks are also widely available and appropriate platforms for the databases of the invention.


The databases of the invention may be used to produce, among other things, electronic Northerns that allow the user to determine the cell type or tissue in which a given gene is expressed and to allow determination of the abundance or expression level of a given gene in a particular tissue or cell.


The databases of the invention may also be used to present information identifying the expression level in a tissue or cell of a set of genes comprising one or more of the genes in Tables 5-5LL, comprising the step of comparing the expression level of at least one gene in Tables 5-5LL in a cell or tissue exposed to a test agent to the level of expression of the gene in the database. Such methods may be used to predict the toxic potential of a given compound by comparing the level of expression of a gene or genes in Tables 5-5LL from a tissue or cell sample exposed to the test agent to the expression levels found in a control tissue or cell samples exposed to a standard toxin or cardiotoxin such as those herein described. Such methods may also be used in the drug or agent screening assays as described herein.


Kits


The invention further includes kits combining, in different combinations, high-density oligonucleotide arrays, reagents for use with the arrays, protein reagents encoded by the genes of the Tables, signal detection and array-processing instruments, gene expression databases and analysis and database management software described above. The kits may be used, for example, to predict or model the toxic response of a test compound, to monitor the progression of heart disease states, to identify genes that show promise as new drug targets and to screen known and newly designed drugs as discussed above.


The databases packaged with the kits are a compilation of expression patterns from human or laboratory animal genes and gene fragments (corresponding to the genes of Tables 1-5LL). In particular, the database software and packaged information that may contain the databases saved to a computer-readable medium include the expression results of Tables 1-5LL that can be used to predict toxicity of a test agent by comparing the expression levels of the genes of Tables 1-5LL induced by the test agent to the expression levels presented in Tables 5-5LL. In another format, database and software information may be provided in a remote electronic format, such as a website, the address of which may be packaged in the kit.


Databases and software designed for use with microarrays is discussed in PCT/US99/20449, filed Sep. 8, 1999, Genomic Knowledge Discovery, PCT/IB00/00863, filed Jun. 28, 2000, Biological Data Processing, and in Balaban et al., U.S. Pat. No. 6,229,911, a computer-implemented method for managing information, stored as indexed tables, collected from small or large numbers of microarrays, and U.S. Pat. No. 6,185,561, a computer-based method with data mining capability for collecting gene expression level data, adding additional attributes and reformatting the data to produce answers to various queries. Chee et al., U.S. Pat. No. 5,974,164, disclose a software-based method for identifying mutations in a nucleic acid sequence based on differences in probe fluorescence intensities between wild type and mutant sequences that hybridize to reference sequences.


The kits may be used in the pharmaceutical industry, where the need for early drug testing is strong due to the high costs associated with drug development, but where bioinformatics, in particular gene expression informatics, is still lacking. These kits will reduce the costs, time and risks associated with traditional new drug screening using cell cultures and laboratory animals. The results of large-scale drug screening of pre-grouped patient populations, pharmacogenomics testing, can also be applied to select drugs with greater efficacy and fewer side-effects. The kits may also be used by smaller biotechnology companies and research institutes who do not have the facilities for performing such large-scale testing themselves.


Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the compounds of the present invention and practice the claimed methods. The following working examples therefore, specifically point out the preferred embodiments of the present invention, and are not to be construed as limiting in any way the remainder of the disclosure.







EXAMPLES
Example 1
Identification of Toxicity Markers

The cardiotoxins adriamycin, amphotericin B, epirubicin, phenylpropanolamine, and rosiglitazone were administered to male Sprague-Dawley rats at various timepoints using administration diluents, protocols, and dosing regimes as indicated in Table 6. The cardiotoxins cyclophosphamide, ifosfamide, minoxidil, hydralazine, BI-QT, clenbuterol, isoproterenol, norepinephrine, and epinephrine and control compositions were administered to male Sprague-Dawley rats at various timepoints using administration diluents, protocols and dosing regimes as previously described in the art and previously described in the priority applications discussed above. The low and high dose level for each compound are provided in the chart below.

Heart ToxinLow Dose (mg/kg)High Dose mg/kgCyclophosphamide20200Ifosfamide5100Minaxidil12 mg/L120 mg/LHydralazine2.525BI-QT1050Clenbuteral0.44Isopraterenal0.050.5Norepinephrine0.050.5Epinephrine0.11Adriamycin1.312.8Amphatericin B0.252.5Epirubicin1.212Phenylpropanolamine6.464Rosiglitazone18180


After administration, the dosed animals were observed and tissues were collected as described below:

OBSERVATION OF ANIMALS1. Clinical Observations-Twice daily: mortality and moribunditycheck. Cage Side Observations - skin andfur, eyes and mucous membrane, respiratorysystem, circulatory system, autonomic andcentral nervous system, somatomotor pattern,and behavior pattern.Potential signs of toxicity, including tremors,convulsions, salivation, diarrhea, lethargy,coma or other atypical behavior orappearance, were recorded as they occurredand included a time of onset, degree, andduration.2. Physical Examinations-Prior to randomization, prior to initialtreatment, and prior to sacrifice.3. Body Weights-Prior to randomization, prior to initialtreatment, and prior to sacrifice.















CLINICAL PATHOLOGY
















1. Frequency
Prior to necropsy.


2. Number of animals
All surviving animals.


3. Bleeding Procedure
Blood was obtained by puncture of the orbital



sinus while under 70% CO2/30% O2



anesthesia.


4. Collection of
Approximately 0.5 mL of blood was


Blood Samples
collected into EDTA tubes for evaluation of



hematology parameters. Approximately 1



mL of blood was collected into serum



separator tubes for clinical chemistry



analysis. Approximately 200 uL of plasma



was obtained and frozen at ˜−80° C. for test



compound/metabolite estimation. An



additional ˜2 mL of blood was collected into



a 15 mL conical polypropylene vial to which



˜3 mL of Trizol was immediately added.



The contents were immediately mixed with a



vortex and by repeated inversion. The tubes



were frozen in liquid nitrogen and stored at



˜−80° C.










Termination Procedures


Terminal Sacrifice


At the sampling times indicated in Tables 5A-5LL and Table 6 for each cardiotoxin, and as previously described in the related applications mentioned above, rats were weighed, physically examined, sacrificed by decapitation, and exsanguinated. The animals were necropsied within approximately five minutes of sacrifice. Separate sterile, disposable instruments were used for each animal, with the exception of bone cutters, which were used to open the skull cap. The bone cutters were dipped in disinfectant solution between animals.


Necropsies were conducted on each animal following procedures approved by board-certified pathologists.


Animals not surviving until terminal sacrifice were discarded without necropsy (following euthanasia by carbon dioxide asphyxiation, if moribund). The approximate time of death for moribund or found dead animals was recorded.


Postmortem Procedures


Fresh and sterile disposable instruments were used to collect tissues. Gloves were worn at all times when handling tissues or vials. All tissues were collected and frozen within approximately 5 minutes of the animal's death. The liver sections and kidneys were frozen within approximately 3-5 minutes of the animal's death. The time of euthanasia, an interim time point at freezing of liver sections and kidneys, and time at completion of necropsy were recorded. Tissues were stored at approximately −80° C. or preserved in 10% neutral buffered formalin.


Tissue Collection and Processing


Liver

    • 1. Right medial lobe—snap frozen in liquid nitrogen and stored at ˜−80° C.
    • 2. Left medial lobe—Preserved in 10% neutral-buffered formalin (NIBF) and evaluated for gross and microscopic pathology.
    • 3. Left lateral lobe—snap frozen in liquid nitrogen and stored at ˜−80° C.


Heart

    • A sagittal cross-section containing portions of the two atria and of the two ventricles was preserved in 10% NBF. The remaining heart was frozen in liquid nitrogen and stored at ˜−80° C.


Kidneys (Both)

    • 1. Left—Hemi-dissected; half was preserved in 10% NBF and the remaining half was frozen in liquid nitrogen and stored at ˜−80° C.
    • 2. Right—Hemi-dissected; half was preserved in 10% NBF and the remaining half was frozen in liquid nitrogen and stored at ˜−80° C.


Testes (Both)

    • A sagittal cross-section of each testis was preserved in 10% NBF. The remaining testes were frozen together in liquid nitrogen and stored at ˜−80° C.


Brain (Whole)

    • A cross-section of the cerebral hemispheres and of the diencephalon was preserved in 10% NBF, and the rest of the brain was frozen in liquid nitrogen and stored at ˜−80° C.


Microarray sample preparation was conducted with minor modifications, following the protocols set forth in the Affymetrix GeneChip Expression Analysis Manual. Frozen tissue was ground to a powder using a Spex Certiprep 6800 Freezer Mill. Total RNA was extracted with Trizol (GibcoBRL) utilizing the manufacturer's protocol. The total RNA yield for each sample was 200-500 μg per 300 mg tissue weight. mRNA was isolated using the Oligotex mRNA Midi kit (Qiagen) followed by ethanol precipitation. Double stranded cDNA was generated from mRNA using the SuperScript Choice system (GibcoBRL). First strand cDNA synthesis was primed with a T7-(dT24) oligonucleotide. The cDNA was phenol-chloroform extracted and ethanol precipitated to a final concentration of 1 μg/ml. From 2 fig of cDNA, cRNA was synthesized using Ambion's T7 MegaScript in vitro Transcription Kit.


To biotin label the cRNA, nucleotides Bio-11-CTP and Bio-16-UTP (Enzo Diagnostics) were added to the reaction. Following a 37° C. incubation for six hours, impurities were removed from the labeled cRNA following the RNeasy Mini kit protocol (Qiagen). cRNA was fragmented (fragmentation buffer consisting of 200 mM Tris-acetate, pH 8.1, 500 mM KOAc, 150 mM MgOAc) for thirty-five minutes at 94° C. Following the Affymetrix protocol, 55 μg of fragmented cRNA was hybridized on the Affymetrix rat array set for twenty-four hours at 60 rpm in a 45° C. hybridization oven. The chips were washed and stained with Streptavidin Phycoerythrin (SAPE) (Molecular Probes) in Affymetrix fluidics stations. To amplify staining, SAPE solution was added twice with an anti-streptavidin biotinylated antibody (Vector Laboratories) staining step in between. Hybridization to the probe arrays was detected by fluorometric scanning (Hewlett Packard Gene Array Scanner). Data was analyzed using Affymetrix GeneChip® version 2.0 and Expression Data Mining (EDMT) software (version 1.0), Gene Logic's GeneExpress® 2000 software and S-Plus™ software.


Tables 1 and 2 disclose those genes that are differentially expressed upon exposure to the named toxins and their corresponding GenBank Accession and Sequence Identification numbers, the identities of the metabolic pathways in which the genes function, the gene names if known, and the unigene cluster titles. The human homologues of the rat genes in Tables 1 and 2 are indicated in Table 3. The model codes in Tables 1-3 represent the various toxicity or heart pathology states that differential expression of each gene is able to identify, as well as the individual toxin or toxin type associated with differential expression of each gene. The model codes are defined in Table 4. The GLGC ID is the internal Gene Logic identification number.


Tables 5A-5LL disclose a core set of genes, along with the summary statistics for each of the comparisons performed as indicated in these tables, i.e., expression levels of a particular gene in toxicity group samples compared to non-toxicity group samples in response to exposure to a particular toxin, or as measured in a particular disease state. Each of these tables contains a set of predictive genes and creates a model for predicting the cardiotoxicity of an unknown, i.e., untested compound. Each gene is identified by its Gene Logic identification number and can be cross-referenced to a gene name and representative sequence identification number in Tables 1 and 2 or in one or more related applications, as mentioned on page 1.


For each comparison of gene expression levels between samples in the toxicity group (samples affected by exposure to a specific toxin) and samples in the non-toxicity group (samples not affected by exposure to that same specific toxin), the tox mean (for toxicity group samples) is the mean signal intensity, as normalized for the various chip parameters that are being assayed. The non-tox mean represents the mean signal intensity, as normalized for the various chip parameters that are being assayed, in samples from animals other than those treated with the high dose of the specific toxin. These animals were treated with a low dose of the specific toxin, or with vehicle alone, or with a different toxin. Samples in the toxicity groups were obtained from animals sacrificed at the timepoint(s) indicated in the Table 5-5LL headings, while samples in the non-toxicity groups were obtained from animals sacrificed at all time points in the experiments. For individual genes, an increase in the tox mean compared to the non-tox mean indicates up-regulation upon exposure to a toxin. Conversely, a decrease in the tox mean compared to the non-tox mean indicates down-regulation.


The mean values are derived from Average Difference (AveDiff) values for a particular gene, averaged across the corresponding samples. Each individual Average Difference value is calculated by integrating the intensity information from multiple probe pairs that are tiled for a particular fragment. The normalization multiplies each expression intensity for a given experiment (chip) by a global scaling factor. The intent of this normalization is to make comparisons of individual genes between chips possible. The scaling factor is calculated as follows:


1. From all the unnormalized expression values in the experiment, delete the largest 2% and smallest 2% of the values. That is, if the experiment yields 10,000 expression values, order the values and delete the smallest 200 and largest 200.


2. Compute the trimmed mean, which is equal to the mean of the remaining values.


3. Compute the scale factor SF=100/(trimmed mean)


Values greater than 2.0* SD noise are assumed to come from expressors. For these values, the standard deviation SD log (signal) of the logarithms is calculated. The logarithms are then multiplied by a scale factor proportional to 1/SD log (signal) and exponentiated. The resulting values are then multiplied by another scale factor, chosen so there will be no discontinuity in the normalized values from unscaled values on either side of 2.0* SD noise. Some AveDiff values may be negative due to the general noise involved in nucleic acid hybridization experiments. Although many conclusions can be made corresponding to a negative value on the GeneChip platform, it is difficult to assess the meaning behind the negative value for individual fragments. Our observations show that, although negative values are observed at times within the predictive gene set, these values reflect a real biological phenomenon that is highly reproducible across all the samples from which the measurement was taken. For this reason, those genes that exhibit a negative value are included in the predictive set. It should be noted that other platforms of gene expression measurement may be able to resolve the negative numbers for the corresponding genes. The predictive ability of each of those genes should extend across platforms, however. Each mean value is accompanied by the standard deviation for the mean. The linear discriminant analysis score (discriminant score, or LDA), as disclosed in the tables, measures the ability of each gene to predict whether or not a sample is toxic. The discriminant score is calculated by the following steps:


Calculation of a Discriminant Score


Let Xi represent the AveDiff values for a given gene across the non-tox samples, i=1 . . . n.


Let Yi represent the AveDiff values for a given gene across the tox samples, i=1 . . . t.


The calculations proceed as follows:


1. Calculate mean and standard deviation for Xi's and Yi's, and denote these by mX, mY, sX, sY.


2. For all Xi's and Yi's, evaluate the function f(z)=((1/sY)*exp(−0.5*((z−mY)/sY)2))/(((1/sY)*exp(−0.5*((z−mY)/sY)2))+((1/sX)*exp(−0.5*((z−mX)/sX)2))).


3. The number of correct predictions, say P, is then the number of Yi's such that f(Yi)>0.5 plus the number of Xi's such that f(Xi)<0.5.


4. The discriminant score is then P/(n+t).


Linear discriminant analysis uses both the individual measurements of each gene and the calculated measurements of all combinations of genes to classify samples. For each gene a weight is derived from the mean and standard deviation of the toxic and nontox groups. Every gene is multiplied by a weight and the sum of these values results in a collective discriminate score. This discriminant score is then compared against collective centroids of the tox and nontox groups. These centroids are the average of all tox and nontox samples respectively. Therefore, each gene contributes to the overall prediction. This contribution is dependent on weights that are large positive or negative numbers if the relative distances between the tox and nontox samples for that gene are large and small numbers if the relative distances are small. The discriminant score for each unknown sample and centroid values can be used to calculate a probability between zero and one as to the group in which the unknown sample belongs.


Example 2
General Toxicity Modeling

Samples were selected for grouping into tox-responding and non-tox-responding groups by examining each study individually with Principal Components Analysis (PCA) to determine which treatments had an observable response. Only groups where confidence of their tox-responding and non-tox-responding status was established were included in building a general tox model (Tables 5A-5LL).


Linear discriminant models were generated to describe toxic and non-toxic samples. The top discriminant genes and/or EST's were used to determine toxicity by calculating each gene's contribution with homo and heteroscedastic treatment of variance and inclusion or exclusion of mutual information between genes. Prediction of samples within the database exceeded 80% true positives with a false positive rate of less than 5%. It was determined that combinations of genes and/or EST's generally provided a better predictive ability than individual genes and that the more genes and/or EST used the better predictive ability. Although the preferred embodiment includes fifty or more genes, many pairings or greater combinations of genes and/or EST can work better than individual genes. All combinations of two or more genes from the selected list (Tables 5A-5LL) could be used to predict toxicity. These combinations could be selected by pairing in an agglomerate, divisive, or random approach. Further, as yet undetermined genes and/or EST's could be combined with individual or combination of genes and/or EST's described here to increase predictive ability. However, the genes and/or EST's described here would contribute most of the predictive ability of any such undetermined combinations.


Other variations on the above method can provide adequate predictive ability. These include selective inclusion of components via agglomerate, divisive, or random approaches or extraction of loading and combining them in agglomerate, divisive, or random approaches. Also the use of composite variables in logistic regression to determine classification of samples can also be accomplished with linear discriminate analysis, neural or Bayesian networks, or other forms of regression and classification based on categorical or continual dependent and independent variables.


Example 3
Modeling with Core Gene Set

As described in Examples 1 and 2, above, the data collected from microarray hybridization experiments were analyzed by LDA and by PCA. The genes in Tables 5G, 5I, 5K, 5M, 5O, 5Q, 5T, 5V, 5X, 5Y, 5Z, 5BB, 5DD, 5FF, and 5KK constitute a core set of markers for predicting the cardiotoxicity of a compound. Each gene fragment in Tables 1-5LL is assigned an LDA score, and those gene fragments in the core set are those with the highest LDA scores. The gene fragments in Tables 5A-5LL were determined to give greater than 80% true positive results and less than 5% false positive results. Gene expression profiles prepared from expression data for these genes, in the presence and absence of toxin treatment, can be used a controls in assays of compounds whose toxic properties have not been examined. Comparison of data from test compound-exposed and test compound-unexposed animals with the data in Tables 5A-5LL, or with data from the core gene set controls, allows the prediction of toxic effects—or no toxic effects—upon exposure to the test compound. Thus, with a smaller gene set than in Table 1 and as described in Example 1, the core gene set can be used to examine the biological effects of a compound whose toxic properties following exposure are not known and to predict the toxicity in liver tissue of this compound.


Example 4
Modeling Methods

The above modeling methods provide broad approaches of combining the expression of genes to predict sample toxicity. One could also provide no weight in a simple voting method or determine weights in a supervised or unsupervised method using agglomerate, divisive, or random approaches. All or selected combinations of genes may be combined in ordered, agglomerate, or divisive, supervised or unsupervised clustering algorithms with unknown samples for classification. Any form of correlation matrix may also be used to classify unknown samples. The spread of the group distribution and discriminate score alone provide enough information to enable a skilled person to generate all of the above types of models with accuracy that can exceed discriminate ability of individual genes. Some examples of methods that could be used individually or in combination after transformation of data types include but are not limited to: Discriminant Analysis, Multiple Discriminant Analysis, logistic regression, multiple regression analysis, linear regression analysis, conjoint analysis, canonical correlation, hierarchical cluster analysis, k-means cluster analysis, self-organizing maps, multidimensional scaling, structural equation modeling, support vector machine determined boundaries, factor analysis, neural networks, bayesian classifications, and resampling methods.


Example 5
Individual Compound Markers

Samples were grouped into individual pathology classes based on known toxicological responses and observed clinical chemical and pathology measurements or into early and late phases of observable toxicity within a compound (Tables 1-5LL). The top 10, 25, 50, 100 genes based on individual discriminate scores were used in a model to ensure that combination of genes provided a better prediction than individual genes. As described above, all combinations of two or more genes from this list could potentially provide better prediction than individual genes when selected in any order or by ordered, agglomerate, divisive, or random approaches. In addition, combining these genes with other genes could provide better predictive ability, but most of this predictive ability would come from the genes listed herein.


Samples may be considered toxic if they score positive in any individual compound represented here or in any modeling method mentioned under general toxicology models based on combination of individual time and dose grouping of individual toxic compounds obtainable from the data. Most logical groupings with one or more genes and one or more sample dose and time points should produce better predictions of general toxicity or similarity to known toxicant than individual genes.


Although the present invention has been described in detail with reference to examples above, it is understood that various modifications can be made without departing from the spirit of the invention. Accordingly, the invention is limited only by the following claims. All cited patents, patent applications and publications referred to in this application are herein incorporated by reference in their entirety.

LENGTHY TABLE REFERENCED HEREUS20070082332A1-20070412-T00001Please refer to the end of the specification for access instructions.
LENGTHY TABLE REFERENCED HEREUS20070082332A1-20070412-T00002Please refer to the end of the specification for access instructions.
TABLE 3Attorney Ref. No. 44921-5090-01-USDocument No. 1918048.1GenBankSEQGLGCAccessionModelHuman Homologous KnownHuman Homologous SequenceIDIDNo.CodeGene NameCluster Title248615408NM_057197f, g, l, m2,4-dienoyl CoA reductase 1,2,4-dienoyl CoA reductase 1,mitochondrialmitochondrial248615409NM_057197f, g2,4-dienoyl CoA reductase 1,2,4-dienoyl CoA reductase 1,mitochondrialmitochondrial198720600NM_017268ii3-hydroxy-3-methylglutaryl-3-hydroxy-3-methylglutaryl-Coenzyme ACoenzyme A synthase 1, 3-synthase 1 (soluble), 3-hydroxy-3-hydroxy-3-methylglutaryl-methylglutaryl-Coenzyme A synthase 2,Coenzyme A synthase 1pre B-cell leukemia transcription factor 1(soluble)198720601NM_017268r3-hydroxy-3-methylglutaryl-3-hydroxy-3-methylglutaryl-Coenzyme ACoenzyme A synthase 1, 3-synthase 1 (soluble), 3-hydroxy-3-hydroxy-3-methylglutaryl-methylglutaryl-Coenzyme A synthase 2,Coenzyme A synthase 1pre B-cell leukemia transcription factor 1(soluble)26917742AA866302c4-hydroxyphenylpyruvate4-hydroxyphenylpyruvate dioxygenase, 4dioxygenase, 4-hydroxyphenylpyruvic acid dioxygenasehydroxyphenylpyruvic aciddioxygenase175320313NM_012585b, u, v5-hydroxytryptamine5-hydroxytryptamine (serotonin) receptor(serotonin) receptor 1A1A1878786NM_013148n, o5-hydroxytryptamine(serotonin) receptor 5A2189767NM_024365b, c5-hydroxytryptamine5-hydroxytryptamine (serotonin) receptor 6(serotonin) receptor 619711527NM_017220ee, ff6-pyruvoyl-tetrahydropterin6-pyruvoyl-tetrahydropterin synthase, 6-synthase, 6-pyruvoyltetrahydropterin synthase,pyruvoyltetrahydropterinESTs, Weakly similar to JC1405 6-synthasepyruvoyltetrahydropterin synthase[H. sapiens], ESTs, Weakly similar toPTPS RAT 6-PYRUVOYLTETRAHYDROBIOPTERIN SYNTHASEPRECURSOR [R. norvegicus]172721882M83740l, m6-pyruvoyl-tetrahydropterinsynthase/dimerizationcofactor of hepatocytenuclear factor 1 alpha (TCF1)269319694Z48444cc, dda disintegrin andESTs, Moderately similar to PC4265metalloprotease domain 10, adisintegrin and metalloproteinase 10disintegrin and[H. sapiens], Homo sapiens cDNAmetalloproteinase domain 10FLJ13398 fis, clone PLACE1001377,highly similar to Homo sapiens ADAM10(ADAM10) mRNA, RIKEN cDNA1700031C13 gene, a disintegrin andmetalloprotease domain 10, a disintegrinand metalloproteinase domain 10219622626NM_024400kka disintegrin-like andESTs, Highly similar to ATS8_MOUSEmetalloprotease (reprolysinADAM-TS 8 PRECURSOR (Atype) with thrombospondinDISINTEGRIN ANDtype 1 motif, 1METALLOPROTEINASE WITHTHROMBOSPONDIN MOTIFS 8)(ADAMTS-8) (ADAM-TS8) (METH-2)[M. musculus], ESTs, Weakly similar toATS1_MOUSE ADAM-TS 1PRECURSOR (A DISINTEGRIN ANDMETALLOPROTEINASE WITHTHROMBOSPONDIN MOTIFS 1)(ADAMTS-1) (ADAM-TS1) [M. musculus],ESTs, Weakly similar to T47158hypothetical protein DKFZp762C1110.1[H. sapiens], Mus musculus, Similar to adisintegrin and metalloproteinase withthrombospondin motifs 1 (ADAMTS-1),clone IMAGE: 3491991, mRNA, partialcds, Mus musculus, Similar to adisintegrin-like and metalloprotease(reprolysin type) with thrombospondintype 1 motif, 4, clone MGC: 38401IMAGE: 5345809, mRNA, complete cds,a disintegrin-like and metalloprotease(reprolysin type) with thrombospondintype 1 motif, 1, a disintegrin-like andmetalloprotease (reprolysin type) withthrombospondin type 1 motif, 8247519658NM_057103ggA kinase (PRKA) anchorA kinase (PRKA) anchor protein (gravin)protein (gravin) 1212, ESTs, Highly similar to gravin[H. sapiens]26302153U75404u, vA kinase (PRKA) anchorA kinase (PRKA) anchor protein (gravin)protein (gravin) 1212, ESTs, Highly similar to gravin[H. sapiens]193018956NM_017075aaacetyl-Coenzyme AHomo sapiens, Similar to acetyl-acetyltransferase 1, acetyl-Coenzyme A acetyltransferase 1Coenzyme A(acetoacetyl Coenzyme A thiolase),acetyltransferase 1clone MGC: 13582 IMAGE: 4278329,(acetoacetyl Coenzyme AmRNA, complete cds, Mus musculus,thiolase)Similar to Acetyl-Co A acetyltransferase1, mitochondrial, clone MGC: 39067IMAGE: 5365469, mRNA, complete cds,acetyl-Coenzyme A acetyltransferase 1(acetoacetyl Coenzyme A thiolase),acetyl-Coenzyme A acyltransferase(peroxisomal 3-oxoacyl-Coenzyme Athiolase)193018957NM_017075r, s, t, llacetyl-Coenzyme AHomo sapiens, Similar to acetyl-acetyltransferase 1, acetyl-Coenzyme A acetyltransferase 1Coenzyme A(acetoacetyl Coenzyme A thiolase),acetyltransferase 1clone MGC: 13582 IMAGE: 4278329,(acetoacetyl Coenzyme AmRNA, complete cds, Mus musculus,thiolase)Similar to Acetyl-Co A acetyltransferase1, mitochondrial, clone MGC: 39067IMAGE: 5365469, mRNA, complete cds,acetyl-Coenzyme A acetyltransferase 1(acetoacetyl Coenzyme A thiolase),acetyl-Coenzyme A acyltransferase(peroxisomal 3-oxoacyl-Coenzyme Athiolase)173223698NM_012489lacetyl-Coenzyme AMus musculus, Similar to Acetyl-Co Aacyltransferase (peroxisomalacetyltransferase 1, mitochondrial, clone3-oxoacyl-Coenzyme AMGC: 39067 IMAGE: 5365469, mRNA,thiolase), acetyl-Coenzyme Acomplete cds, acetyl-Coenzyme Aacyltransferase 1acyltransferase (peroxisomal 3-oxoacyl-(peroxisomal 3-oxoacyl-Coenzyme A thiolase), acetyl-CoenzymeCoenzyme A thiolase)A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)203718569NM_019212f, w, x,actin, alpha 1, skeletalBRG1/brm-associated factor 53A, Rathhmusclemessenger RNA for alpha-actin, actin,alpha 1, skeletal muscle, actin-like 6,expressed sequence AA95994327516001AA866452bb, cc,actin, alpha, cardiac, actin,ESTs, Weakly similar to ACTA_HUMANddalpha, cardiac muscleActin, aortic smooth muscle (Alpha-actin2) [R. norvegicus], Homo sapiens, cloneMGC: 33407 IMAGE: 4824606, mRNA,complete cds, actin, alpha 2, smoothmuscle, aorta, smooth muscle alpha-actin221221166NM_031005a, n, oactinin, alpha 1ESTs, Weakly similar to alpha actinin 4[Mus musculus] [M. musculus], RIKENcDNA 3110023F10 gene, actinin alpha2, actinin alpha 3, actinin, alpha 1,actinin, alpha 2, actinin, alpha 3, alphaactinin 423075358NM_031675ractinin, alpha 4, alpha actinin 4ESTs, Weakly similar to alpha actinin 4[Mus musculus] [M. musculus], RIKENcDNA 3110023F10 gene, actinin, alpha4, alpha actinin 4182124431NM_012912a, p, q, y,activating transcription factor 3ESTs, Weakly similar to A39382 liverz, ee, ffregeneration factor LRF1 - rat[R. norvegicus], ESTs, Weakly similar toA54025 transcription factor ATF3[H. sapiens], activating transcriptionfactor3186420242NM_013084ggacyl-Coenzyme Aacyl-Coenzyme A dehydrogenase,dehydrogenase,short/branched chainshort/branched chain90317957AI028975s, tadaptor protein complex Ap-adaptor protein complex AP-1, beta 11, beta 1 subunit, adaptor-subunit, adaptor-related protein complexrelated protein complex 1,1, beta 1 subunitbeta 1 subunit199017959NM_017277s, tadaptor protein complex AP-adaptor protein complex AP-1, beta 11, beta 1 subunit, adaptor-subunit, adaptor-related protein complexrelated protein complex 1,1, beta 1 subunitbeta 1 subunit249517958NM_080583ggadaptor-related proteinadaptor protein complex AP-1, beta 1complex 2, beta 1 subunitsubunit, adaptor-related protein complex2, beta 1 subunit249517960NM_080583radaptor-related proteinadaptor protein complex AP-1, beta 1complex 2, beta 1 subunitsubunit, adaptor-related protein complex2, beta 1 subunit23661596NM_053294radenosine A2a receptoradenosine A2a receptor, adenosine A3receptor181616708NM_012895u, vadenosine kinaseadenosine kinase, expressed sequenceAI98781420538200NM_019285lladenylate cyclase 4ESTs, Moderately similar to A41542adenylate cyclase (EC 4.6.1.1) IV - rat[R. norvegicus], adenylate cyclase 2(brain), adenylate cyclase 4252124775NM_133511cadenylate cyclase activatingESTs, Weakly similar to PACR MOUSEpolypeptide 1 (pituitary)PITUITARY ADENYLATE CYCLASEreceptor type I, adenylateACTIVATING POLYPEPTIDE TYPE Icyclase activating polypeptideRECEPTOR PRECURSOR1 receptor 1[M. musculus], adenylate cyclaseactivating polypeptide 1 (pituitary)receptor type I, adenylate cyclaseactivating polypeptide 1 receptor 1190517972NM_016989l, madenylate cyclase activatingadenylate cyclase activating polypeptidepolypeptide 1, adenylate1, adenylate cyclase activatingcyclase activating polypeptidepolypeptide 1 (pituitary)1 (pituitary)257713712NM_144744iiadipose most abundant geneESTs, Highly similar to 1917150Atranscript 1collagen: SUBUNIT = alpha1:ISOTYPE = VIII [Rattus norvegicus] [R. norvegicus],ESTs, Moderately similar to CA18MOUSE COLLAGEN ALPHA 1(VIII)CHAIN PRECURSOR [M. musculus],ESTs, Weakly similar to ACR3 MOUSE30 KD ADIPOCYTE COMPLEMENT-RELATED PROTEIN PRECURSOR[M. musculus], Mus musculus, Similar toDKFZP586B0621 protein, cloneMGC: 38635 IMAGE: 5355789, mRNA,complete cds, RIKEN cDNA5530401N20 gene, adipose mostabundant gene transcript 1, collagen,type VIII, alpha 1, procollagen, type VIII,alpha 117283762M86341s, tADP-ribosylarginineADP-ribosylarginine hydrolase, ESTs,hydrolaseWeakly similar to ADP-RIBOSYLARGININE HYDROLASE[M. musculus]203224019NM_019186j, kADP-ribosylation factor-like 4,ADP-ribosylation factor 4-like, ADP-ADP-ribosylation-like 4ribosylation factor-like 7, ADP-ribosylation-like 4, ESTs, Weakly similarto ADP-ribosylation-like 4 [Musmusculus] [M. musculus], Mus musculus,Similar to ADP-ribosylation-like 4, cloneMGC: 5774 IMAGE: 3599701, mRNA,complete cds, RIKEN cDNA1110036H21 gene, epithelial protein lostin neoplasm beta7353505AA998430w, xadrenergic receptor kinase,ESTs, Weakly similar to GRK6 MOUSEbeta 1, adrenergic, beta,G PROTEIN-COUPLED RECEPTORreceptor kinase 1KINASE GRK6 [M. musculus], G protein-coupled receptor kinase 6, adrenergicreceptor kinase, beta 1, adrenergic,beta, receptor kinase 1190664NM_016991jj, kkadrenergic receptor, alpha 1b,adrenergic, alpha-1B-,receptor1778322NM_012715d, ggadrenomedullinadrenomedullin172510743M64780r, jj, kkagrinESTs, Weakly similar to A38096perlecan precursor [H. sapiens], ESTs,Weakly similar to AGRT agrin - rat[R. norvegicus], ESTs, Weakly similar toBASEMENT MEMBRANE-SPECIFICHEPARAN SULFATE PROTEOGLYCANCORE PROTEIN PRECURSOR[M. musculus], ESTs, Weakly similar toPGBM_HUMAN BASEMENTMEMBRANE-SPECIFIC HEPARANSULFATE PROTEOGLYCAN COREPROTEIN PRECURSOR [H. sapiens],Mus musculus, clone IMAGE: 3494258,mRNA, partial cds, heparan sulfateproteoglycan 2 (perlecan), perlecan(heparan sulfate proteoglycan 2), serineprotease inhibitor, Kazal type, 5,sialoadhesin, transmembrane proteinwith EGF-like and two follistatin-likedomains 1172510744M64780fagrinESTs, Weakly similar to A38096perlecan precursor [H. sapiens], ESTs,Weakly similar to AGRT agrin - rat[R. norvegicus], ESTs, Weakly similar toBASEMENT MEMBRANE-SPECIFICHEPARAN SULFATE PROTEOGLYCANCORE PROTEIN PRECURSOR[M. musculus], ESTs, Weakly similar toPGBM_HUMAN BASEMENTMEMBRANE-SPECIFIC HEPARANSULFATE PROTEOGLYCAN COREPROTEIN PRECURSOR [H. sapiens],Mus musculus, clone IMAGE: 3494258,mRNA, partial cds, heparan sulfateproteoglycan 2 (perlecan), perlecan(heparan sulfate proteoglycan 2), serineprotease inhibitor, Kazal type, 5,sialoadhesin, transmembrane proteinwith EGF-like and two follistatin-likedomains 1208223424NM_021680j, kalanyl-tRNA synthetasealanyl-tRNA synthetase211820915NM_022407kkaldehyde dehydrogenase 1Mus musculus, Similar to aldehydefamily, member A1, aldehydedehydrogenase 8 family, member A1,dehydrogenase family 1,clone IMAGE: 4234742, mRNA, partialsubfamily A1cds, aldehyde dehydrogenase 1 family,member A1, aldehyde dehydrogenasefamily 1, subfamily A1235312299NM_032416caldehyde dehydrogenase 2ESTs, Moderately similar to DHAM_RATfamily (mitochondrial),ALDEHYDE DEHYDROGENASE,aldehyde dehydrogenase 2,MITOCHONDRIAL PRECURSOR (ALDHmitochondrialCLASS 2) (ALDH1) (ALDH-E2)[R. norvegicus], RIKEN cDNA2410004H02 gene, aldehydedehydrogenase 1 family, member B1,aldehyde dehydrogenase 2 family(mitochondrial), aldehydedehydrogenase 2, mitochondrial11911901AA801058daldehyde dehydrogenase 9Mus musculus, Similar to aldehydefamily, member A1, aldehydedehydrogenase 4 family, member A1,dehydrogenase 9, subfamilyclone IMAGE: 5102023, mRNA, partialA1cds, RIKEN cDNA 1110038l05 gene,aldehyde dehydrogenase 4 family,member A1, aldehyde dehydrogenase 9family, member A1, aldehydedehydrogenase 9, subfamily A1173315511NM_012498iialdo-keto reductase family 1,EST, Weakly similar to A39763 aldehydemember B1 (aldosereductase [H. sapiens], ESTs, Moderatelyreductase), aldo-ketosimilar to ALDR_RAT Aldose reductasereductase family 1, member(AR) (Aldehyde reductase)B3 (aldose reductase)[R. norvegicus], ESTs, Weakly similar toALDR_RAT Aldose reductase (AR)(Aldehyde reductase) [R. norvegicus],Rattus norvegicus mRNA for aldosereductase-like protein, aldo-ketoreductase family 1, member B1 (aldosereductase), aldo-keto reductase family 1,member B3 (aldose reductase)180215032NM_012816j, k, jj, kkalpha-methylacyl-CoAalpha-methylacyl-CoA racemase, cDNAracemasesequence AF397014, chromosome 7open reading frame 1020392079NM_019220camino-terminal enhancer ofamino-terminal enhancer of splitsplit266325711X60468s, tamyloid beta (A4) precursorMus musculus, Similar to amyloid betaprotein-binding, family B,(A4) precursor protein-binding, family B,member 1, amyloid beta (A4)member 3, clone MGC: 38710precursor protein-bindingIMAGE: 5357681, mRNA, complete cds,family B, member 1 (Fe65)amyloid beta (A4) precursor protein-binding, family B, member 1, amyloidbeta (A4) precursor protein-binding,family B, member 1 (Fe65), amyloid beta(A4) precursor protein-binding, family B,member 21745225NM_012544aa, bbangiotensin I convertingESTs, Highly similar to A31759 peptidyl-enzyme (peptidyl-dipeptidasedipeptidase A [H. sapiens], RIKEN cDNAA) 1, angiotensin converting2010305L05 gene, angiotensin Ienzymeconverting enzyme (peptidyl-dipeptidaseA) 1, angiotensin converting enzyme18187196NM_012904a, llannexin A1annexin A1136615315AI177911h, lannexin A2annexin A2, annexin A92073574NM_019905a, h, l, z,annexin A2, hydroxyacidEST, Moderately similar to 0806162Caa, kk, lloxidase (glycolate oxidase) 3,protein COI [M. musculus], EST,hydroxyacid oxidase 3Moderately similar to 810024C(medium-chain)cytochrome oxidase I [H. sapiens], EST,Weakly similar to 08061620C protein COI[M. musculus], ESTs, Highly similar tohydroxyacid oxidase 3 (medium-chain)[Rattus norvegicus] [R. norvegicus],ESTs, Moderately similar to 0806162Cprotein COI [M. musculus], ESTs,Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], ESTs,Weakly similar to 0806162C protein COI[M. musculus], annexin A2, annexin A9,hydroxyacid oxidase (glycolate oxidase)3, hydroxyacid oxidase 1, liver15598440AI235611bnaaexin A4ESTs, Moderately similar to ANX4MOUSE ANNEXIN IV [M. musculus],ESTs, Weakly similar to ZAP 36/annexinIV [Rattus norvegicus] [R. norvegicus],Mus musculus, Similar to annexin A8,clone MGC: 13875 IMAGE: 4013266,mRNA, complete cds, annexin A13,annexin A4, annexin A82181561NM_024156jj, kkannexin A6annexin A62181562NM_024156rannexin A6annexin A6239819252NM_053576aanti-oxidant protein 2 (non-ESTs, Moderately similar to AOP2selenium glutathioneMOUSE ANTIOXIDANT PROTEIN 2peroxidase, acidic calcium-[M. musculus], ESTs, Moderately similarindependent phospholipaseto AOP2_HUMAN ANTIOXIDANTA2), peroxiredoxin 5PROTEIN 2 [H. sapiens], anti-oxidantprotein 2 (non-selenium glutathioneperoxidase, acidic calcium-independentphospholipase A2), peroxiredoxin 518191834NM_012905daortic preferentiallyaortic preferentially expressed gene 1,expressed gene 1, nuclearnuclear protein, marker for differentiatedprotein, marker foraortic smooth muscle and down-differentiated aortic smoothregulated with vascular injurymuscle and down-regulatedwith vascular injury217720801NM_024148d, s, tAPEX nucleaseAPEX nuclease (multifunctional DNA(multifunctional DNA repairrepair enzyme), Mus musculus ape2enzyme),mRNA for AP endonuclease 2, completeapurinic/apyrimidiniccds, apurinic/apyrimidinic endonucleaseendonuclease255216400NM_138828cc, ddapolipoprotein Eapolipoprotein E17935758NM_012778p, q, s, taquaporin 1, aquaporin 1aquaporin 1, aquaporin 1 (channel-(channel-forming integralforming integral protein, 28 kD)protein, 28 kD)1794104NM_012779iiaquaporin 5aquaporin 5, aquaporin 619867593NM_017260w, xarachidonate 5-lipoxygenasearachidonate 5-lipoxygenase activatingactivating protein,protein, arachidonate 5-lipoxygenase-arachidonate 5-lipoxygenase-activating proteinactivating protein19867594NM_017260w, x, iiarachidonate 5-lipoxygenasearachidonate 5-lipoxygenase activatingactivating protein,protein, arachidonate 5-lipoxygenase-arachidonate 5-lipoxygenase-activating proteinactivating protein190724868NM_016992n, oarginine vasopressin, argininearginine vasopressin, argininevasopressin (neurophysin ll,vasopressin (neurophysin ll, antidiureticantidiuretic hormone,hormone, diabetes insipidus,diabetes insipidus,neurohypophyseal)neurohypophyseal)190724869NM_016992n, oarginine vasopressin, argininearginine vasopressin, argininevasopressin (neurophysin ll,vasopressin (neurophysin ll, antidiureticantidiuretic hormone,hormone, diabetes insipidus,diabetes insipidus,neurohypophyseal)neurohypophyseal)146423013AI230743hhARP3 actin-related protein 3ARP3 actin-related protein 3 homologhomolog (yeast), actin-related(yeast), EST, Weakly similar toprotein 3 homolog (yeast)ARP3_HUMAN ACTIN-LIKE PROTEIN 3[H. sapiens], EST, Weakly similar toATRT actin, skeletal muscle - rat[R. norvegicus], ESTs, Moderately similarto ARP3_HUMAN ACTIN-LIKEPROTEIN 3 [H. sapiens], ESTs, Weaklysimilar to ATHU actin alpha 1, skeletalmuscle [H. sapiens], Homo sapienscDNA FLJ14201 fis, cloneNT2RP3002955, actin-related protein 3-beta, hypothetical protein FLJ12785,mitochondrial ribosomal protein L47200016844NM_017311n, oATP synthase, H+ATP synthase, H+ transporting,transporting, mitochondrial F0mitochondrial F0 complex, subunit ccomplex, subunit c (subunit(subunit 9), isoform 1, ESTs, Highly9), isoform 1similar to AT91_HUMAN ATPSYNTHASE LIPID-BINDING PROTEINP1 PRECURSOR [H. sapiens], Homosapiens cDNA: FLJ23586 fis, cloneLNG14376256617203NM_139099g, hhATP synthase, H+ATP synthase, H+ transporting,transporting, mitochondrial F1mitochondrial F1 complex, epsiloncomplex, epsilon subunitsubunit, RIKEN cDNA 2410043G19gene, expressed sequence AV000645256617204NM_139099gATP synthase, H+ATP synthase, H+ transporting,transporting, mitochondrial F1mitochondrial F1 complex, epsiloncomplex, epsilon subunitsubunit, RIKEN cDNA 2410043G19gene, expressed sequence AV000645199412347NM_017290llATPase, Ca++ transporting,cardiac muscle, slow twitch 2199412349NM_017290aaATPase, Ca++ transporting,cardiac muscle, slow twitch 2173117991M96626cc, dd,ATPase, Ca++ transporting,ATPase, Ca++ transporting, plasmaggplasma membrane 3membrane 2, ATPase, Class V, type10C, ATPase, class V, type 10A, ESTs,Highly similar to A34308 Ca2+-transporting ATPase [R. norvegicus],ESTs, Weakly similar to 149143 gastricH(+)-K(+)-ATPase alpha subunit - mouse[M. musculus], RIKEN cDNA 1110019l14gene, RIKEN cDNA 2810442122 gene182224783NM_012914kkATPase, Ca++ transporting,ATPase, Ca++ transporting, ubiquitousubiquitous1734583NM_012505h, lATPase, Na+/K+ transporting,ATPase, Na+/K+ transporting, alpha 2alpha 2 (+) polypeptide,(+) polypeptide, ATPase, Na+/K+ATPase, Na+/K+ transporting,transporting, alpha 2 polypeptide,alpha 2 polypeptideATPase, Na+/K+ transporting, alpha 4polypeptide, ESTs, Highly similar toA1A4_HUMAN Sodium/potassium-transporting ATPase alpha-4 chain(Sodium pump 4) (Na+/K+ ATPase 4)[H. sapiens], expressed sequenceAW06065417265733M81855dATP-binding cassette, sub-ATP-binding cassette, sub-family Bfamily B (MDR/TAP), member(MDR/TAP), member 1, ATP-binding1, ATP-binding cassette, sub-cassette, sub-family B (MDR/TAP),family B (MDR/TAP), membermember 1A, ATP-binding cassette, sub-1Bfamily B (MDR/TAP), member 1B, EST,Highly similar to MDR3 MOUSEMULTIDRUG RESISTANCE PROTEIN 3[M. musculus], EST, Weakly similar toMULTIDRUG RESISTANCE PROTEIN 3[M. musculus], ESTs, Weakly similar toMDR1 MOUSE MULTIDRUGRESISTANCE PROTEIN 1[M. musculus], Mus musculus, cloneIMAGE: 3588242, mRNA, partial cds26561037X57523dATP-binding cassette, sub-ATP-binding cassette, sub-family Bfamily B (MDR/TAP), member(MDR/TAP), member 2, ESTs, Highly2, transporter 1, ATP-bindingsimilar to S13426 multidrug resistancecassette, sub-family Bprotein homolog - rat [R. norvegicus],(MDR/TAP)transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)1853733NM_013040j, kATP-binding cassette, sub-ATP-binding cassette, sub-family Cfamily C (CFTR/MRP),(CFTR/MRP), member 9, ESTs, Weaklymember 9similar to T42751 sulfonylurea receptor 2- rat [R. norvegicus], Homo sapienscDNA FLJ31957 fis, cloneNT2RP7007381, highly similar toSulfonylurea receptor 2A, Mus musculusadult male pituitary gland cDNA, RIKENfull-length enriched library,clone: 5330439B14: ATP-bindingcassette, sub-family C (CFTR/MRP),member 9, full insert sequence7283511AA998152ee, ffBAI1-associated protein 2,BAI1-associated protein 2, ESTs,brain-specific angiogenesisWeakly similar to brain-specificinhibitor 1-associated protein 2angiogenesis inhibitor 1-associatedprotein 2 [Mus musculus] [M. musculus],Mus musculus, Similar to KIAA0429gene product, clone IMAGE: 2811240,mRNA, partial cds, RIKEN cDNA1300006M19 gene, brain-specificangiogenesis inhibitor 1-associatedprotein 2, hypothetical protein FLJ22582,insulin receptor tyrosine kinase substrate23701063NM_053328ebasic helix-loop-helix domainbasic helix-loop-helix domain containing,containing, class B, 2, basicclass B, 2, basic helix-loop-helix domainhelix-loop-helix domaincontaining, class B, 3, basic helix-loop-containing, class B2helix domain containing, class B2, basichelix-loop-helix domain containing, classB325141061NM_133303p, q, hhbasic helix-loop-helix domainbasic helix-loop-helix domain containing,containing, class B, 3, basicclass B, 2, basic helix-loop-helix domainhelix-loop-helix domaincontaining, class B2, basic helix-loop-containing, class B3helix domain containing, class B3198419NM_017258p, qB-cell translocation gene 1,B-cell translocation gene 1, anti-anti-proliferativeproliferative, Homo sapiens cDNAFLJ30547 fis, clone BRAWH2001439,transducer of ERBB2, 1, transducer ofERBB2, 2, transducer of ErbB-2.1198515300NM_017259p, q, kkB-cell translocation gene 2,B-cell translocation gene 2, anti-anti-proliferative, BTG family,proliferative, B-cell translocation gene 4,member 2BTG family, member 2, ESTs, Highlysimilar to BTG2_HUMAN BTG2PROTEIN PRECURSOR [H. sapiens]198515301NM_017259j, k, p, q,B-cell translocation gene 2,B-cell translocation gene 2, anti-y, z, gganti-proliferative, BTG family,proliferative, B-cell translocation gene 4,member 2BTG family, member 2, ESTs, Highlysimilar to BTG2_HUMAN BTG2PROTEIN PRECURSOR [H. sapiens]198515299NM_017259y, zB-cell translocation gene 2,B-cell translocation gene 2, anti-anti-proliferative, BTG family,proliferative, B-cell translocation gene 4,member 2BTG family, member 2, ESTs, Highlysimilar to BTG2_HUMAN BTG2PROTEIN PRECURSOR [H. sapiens]1924910NM_017059dBCL2-associated X protein,Bcl2-associated X protein1924911NM_017059dBCL2-associated X protein,Bcl2-associated X protein1924912NM_017059d, l, mBCL2-associated X protein,Bcl2-associated X protein191317815NM_017015w, xbeta-glucuronidase,ESTs, Highly similar to A26581 beta-glucuronidase, betaglucuronidase [H. sapiens], SMA3, beta-glucuronidase structural, glucuronidase,beta2512262AA859757hhcollagen, type V, alpha 1,EST, Weakly similar to CGHU1Vprocollagen, type V, alpha 1collagen alpha 1(V) chain precursor[H. sapiens], Homo sapiens cDNAFLJ30442 fis, clone BRACE2009212,Homo sapiens proline-rich acidic proteinmRNA, complete cds, Mus musculus,clone IMAGE: 3490511, mRNA, partialcds, collagen, type V, alpha 1, collagen,type XI, alpha 1, endoplasmic reticulumchaperone SIL1, homolog of yeast,hypothetical protein MGC2705,procollagen, type V, alpha 1,procollagen, type V, alpha 3,procollagen, type XI, alpha 1254425237NM_134452rcollagen, type V, alpha 1,EST, Weakly similar to CGHU1Vprocollagen, type V, alpha 1collagen alpha 1(V) chain precursor[H. sapiens], Homo sapiens cDNAFLJ30442 fis, clone BRACE2009212,Homo sapiens proline-rich acidic proteinmRNA, complete cds, Mus musculus,clone IMAGE: 3490511, mRNA, partialcds, collagen, type V, alpha 1, collagen,type XI, alpha 1, endoplasmic reticulumchaperone SIL1, homolog of yeast,hypothetical protein MGC2705,procollagen, type V, alpha 1,procollagen, type V, alpha 3,procollagen, type XI, alpha 1139915438AI179399e, gcollagen, type V, alpha 2,EST, Weakly similar to CGHU2Vprocollagen, type V, alpha 2collagen alpha 2(V) chain precursor[H. sapiens], EST, Weakly similar toI49607 procollagen type V alpha 2 -mouse [M. musculus], ESTs, Weaklysimilar to I49607 procollagen type Valpha 2 - mouse [M. musculus], ESTs,Weakly similar to S41067 collagen alpha1(III) chain - rat [R. norvegicus], Musmusculus, Similar to putative proteinphosphatase 1 nuclear targeting subunit,clone IMAGE: 3157989, mRNA, partialcds, RIKEN cDNA 2810002D19 gene,collagen, type V, alpha 2, procollagen,type III, alpha 1, procollagen, type V,alpha 2205021443NM_019262kk, IIcomplement component 1, qsubcomponent, betapolypeptide205021444NM_019262jj, kkcomplement component 1, qsubcomponent, betapolypeptide23041727NM_031642jj, kkcore promoter elementDNA segment, Chr 12, ERATO Doi 427,binding proteinexpressed, EST, Moderately similar tocore promoter element binding protein[Rattus norvegicus] [R. norvegicus],ESTs, Weakly similar to core promoterelement binding protein [Rattusnorvegicus] [R. norvegicus], Kruppel-likefactor 7 (ubiquitous), core promoterelement binding protein204015347NM_019222IIcoronin, actin binding proteinESTs, Moderately similar to CO1B_RAT1B, coronin, actin-bindingCoronin 1B (Coronin 2) [R. norvegicus],protein, 1Bcoronin 6, coronin, actin binding protein1B, coronin, actin binding protein 1C,coronin, actin binding protein, 1C,hypothetical protein DKFZp762I16617394467NM_012529f, gcreatine kinase, brain17394468NM_012529gcreatine kinase, brain174220357NM_012534cc, ddcrystallin, alpha Acrystallin, alpha A, expressed sequenceAI323437182913723NM_012935aa, bbcrystallin, alpha BESTs, Moderately similar to T46637transcription factor 1, neural - rat[R. norvegicus], ESTs, Weakly similar toA35804 nucleolin [H. sapiens], ESTs,Weakly similar to alpha-crystallin chain B[M. musculus], Homo sapiens mRNA;cDNA DKFZp434E0922 (from cloneDKFZp434E0922), Mus musculus 10, 11days embryo whole body cDNA, RIKENfull-length enriched library,clone: 2810003I18: myelin transcriptionfactor 1-like, full insert sequence,crystallin, alpha B, myelin transcriptionfactor 1-like, nucleolin1830487NM_012937ncrystallin, beta B2EST, Highly similar to CRB2_MOUSEBETA CRYSTALLIN B2 (BP)[R. norvegicus], EST, Weakly similar to AChain A, The N-Terminal Domain OfBeta-B2-Crystallin Resembles ThePutative Ancestral Homodimer[M. musculus], Homo sapiens, cloneIMAGE: 3542716, mRNA, partial cds,crystallin, beta B223128844NM_031690bcrystallin, beta B3absent in melanoma 1, absent inmelanoma 1-like, crystallin, beta B3203518572NM_019201n, oC-terminal binding protein 1C-terminal binding protein 1, Homosapiens mRNA; cDNA DKFZp434B0914(from clone DKFZp434B0914); partialcds203518573NM_019201f, gC-terminal binding protein 1C-terminal binding protein 1, Homosapiens mRNA; cDNA DKFZp434B0914(from clone DKFZp434B0914); partialcds165725041D14014fcyclin D1, cyclin D1 (PRAD1:EST, Moderately similar to JC2342 cyclinparathyroid adenomatosis 1)D1 - rat [R. norvegicus], cyclin D1, cyclinD1 (PRAD1: parathyroid adenomatosis1)267724232X75207aa, bbcyclin D1, cyclin D1 (PRAD1:EST, Moderately similar to JC2342 cyclinparathyroid adenomatosis 1)D1 - rat [R. norvegicus], cyclin D1, cyclinD1 (PRAD1: parathyroid adenomatosis1)182520757NM_012923cc, ddcyclin G, cyclin G1ESTs, Weakly similar to CGG1_RATCyclin G1 (Cyclin G) [R. norvegicus],cyclin G, cyclin G2, cyclin I146814430AI230798rcyclin-dependent kinasecyclin-dependent kinase inhibitor 3inhibitor 3 (CDK2-associated(CDK2-associated dual specificitydual specificity phosphatase)phosphatase)18042853NM_012838n, ocystatin B, cystatin B (stefincystatin B, cystatin B (stefin B)B)148224327AI231292ggcystatin C, cystatin CESTs, Moderately similar to CYTC(amyloid angiopathy andMOUSE CYSTATIN C PRECURSORcerebral hemorrhage)[M. musculus], ESTs, Weakly similar toCYTC MOUSE CYSTATIN CPRECURSOR [M. musculus], RIKENcDNA 1110017E11 gene, RIKEN cDNA9230101F08 gene, cystatin C, cystatin C(amyloid angiopathy and cerebralhemorrhage), cystatin D, cystatin S,cystatin SA, cystatin SN24831892NM_057144a, o, x,cysteine and glycine-richRIKEN cDNA 1200007O21 gene,ee, ff, kkprotein 3 (cardiac LIMcysteine and glycine-rich protein 3protein), cysteine-rich protein 3(cardiac LIM protein), cysteine-richprotein 3196814694NM_017202aacytochrome c oxidase subunitEST, Weakly similar to COX4_HUMANIV isoform 1, cytochrome cCYTOCHROME C OXIDASEoxidase, subunit IVaPOLYPEPTIDE IV PRECURSO[H. sapiens], ESTs, Moderately similar toCOX4_HUMAN CYTOCHROME COXIDASE POLYPEPTIDE IVPRECURSO [H. sapiens], cytochrome coxidase subunit IV isoform 1,cytochrome c oxidase, subunit IVa238321866NM_053472u, vcytochrome c oxidase subunitcytochrome c oxidase subunit IV isoformIV isoform 2, cytochrome c2, cytochrome c oxidase, subunit IVboxidase, subunit IVb113823574AI104520hhcytochrome c oxidase subunitVla polypeptide 1,cytochrome c oxidase,subunit VI a, polypeptide 1174320704NM_012541aa, bbcytochrome P450, 1a2,cytochrome P450, 1a2, aromaticaromatic compound inducible,compound inducible, cytochrome P450,cytochrome P450, subfamily Isubfamily I (aromatic compound-(aromatic compound-inducible), polypeptide 2inducible), polypeptide 21831190NM_012940j, kcytochrome P450, 1b1,cytochrome P450, 1b1,benz[a]anthracene inducible,benz[a]anthracene inducible,cytochrome P450, subfamily Icytochrome P450, subfamily I (dioxin-(dioxin-inducible), polypeptideinducible), polypeptide 1 (glaucoma 3,1 (glaucoma 3, primaryprimary infantile)infantile)22814010NM_031543u, vcytochrome P450, 2e1,ethanol inducible, cytochromeP450, subfamily IIE (ethanol-inducible)22814011NM_031543vcytochrome P450, 2e1,ethanol inducible, cytochromeP450, subfamily IIE (ethanol-inducible)183220928NM_012941l, mcytochrome P450, 51,cytochrome P450, 51, cytochrome P450,cytochrome P450, 5151 (lanosterol 14-alpha-demethylase)(lanosterol 14-alpha-demethylase)170820714M14972s, tcytochrome P450, subfamilyEST, Moderately similar to I65981 fattyIV B, polypeptide 1,acid omega-hydroxylase [H. sapiens],cytochrome P450, subfamilyMus musculus, Similar to cytochromeIVB, polypeptide 1P450, 4a10, clone MGC: 18880IMAGE: 4237837, mRNA, complete cds,Mus musculus, Similar to cytochromeP450, 4a10, clone MGC: 25972IMAGE: 4240359, mRNA, complete cds,RIKEN cDNA A230105L22 gene,cytochrome P450, 4a10, cytochromeP450, subfamily IVA, polypeptide 11,expressed sequence AI314743190920921NM_016999s, tcytochrome P450, subfamilyEST, Moderately similar to I65981 fattyIV B, polypeptide 1,acid omega-hydroxylase [H. sapiens],cytochrome P450, subfamilyMus musculus, Similar to cytochromeIVB, polypeptide 1P450, 4a10, clone MGC: 18880IMAGE: 4237837, mRNA, complete cds,Mus musculus, Similar to cytochromeP450, 4a10, clone MGC: 25972IMAGE: 4240359, mRNA, complete cds,RIKEN cDNA A230105L22 gene,cytochrome P450, 4a10, cytochromeP450, subfamily IVA, polypeptide 11,expressed sequence AI31474317441762NM_012543fD site albumin promoterD site albumin promoter binding protein,binding protein, D site ofD site of albumin promoter (albumin D-albumin promoter (albumin D-box) binding protein, RIKEN cDNAbox) binding protein2310028D20 gene17441763NM_012543hhD site albumin promoterD site albumin promoter binding protein,binding protein, D site ofD site of albumin promoter (albumin D-albumin promoter (albumin D-box) binding protein, RIKEN cDNAbox) binding protein2310028D20 gene217417226NM_024131b, c, u, vD-dopachrome tautomeraseD-dopachrome tautomerase, EST,Moderately similar to DOPD_HUMAN D-DOPACHROME TAUTOMERASE[H. sapiens]217417227NM_024131cD-dopachrome tautomeraseD-dopachrome tautomerase, EST,Moderately similar to DOPD_HUMAN D-DOPACHROME TAUTOMERASE[H. sapiens]269118352Z12298aa, bbdecorinRIKEN cDNA 5530600M07 gene,decorin, expressed sequence C85409,extracellular matrix protein 2, femaleorgan and adipocyte specific22601638NM_031143d, e, ii,diacylglycerol kinase zeta,EST, Weakly similar to diacylglycerolkkdiacylglycerol kinase, zetakinase zeta [Rattus norvegicus](104 kD)[R. norvegicus], ESTs, Highly similar toKDGA MOUSE DIACYLGLYCEROLKINASE, ALPHA [M. musculus], ESTs,Weakly similar to diacylglycerol kinase[Rattus norvegicus] [R. norvegicus],ESTs, Weakly similar to KDGA MOUSEDIACYLGLYCEROL KINASE, ALPHA[M. musculus], diacylglycerol kinase,alpha (80 kDa), diacylglycerol kinase,gamma 3, diacylglycerol kinase, iota,diacylglycerol kinase, zeta (104 kD)119424AA850922h, ldimethylarginineESTs, Highly similar to DDH1_HUMANdimethylaminohydrolase 1NG, NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1[H. sapiens], ESTs, Weakly similar todimethylargininedimethylaminohydrolase 1; NG, NGdimethylargininedimethylaminohydrolase [Rattusnorvegicus] [R. norvegicus],dimethylargininedimethylaminohydrolase 1,dimethylargininedimethylaminohydrolase 2319421AA945152bbdimethylarginineESTs, Highly similar to DDH1_HUMANdimethylaminohydrolase 1NG, NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1[H. sapiens], ESTs, Weakly similar todimethylargininedimethylaminohydrolase 1; NG, NGdimethylargininedimethylaminohydrolase [Rattusnorvegicus] [R. norvegicus],dimethylargininedimethylaminohydrolase 1,dimethylargininedimethylaminohydrolase 2210419423NM_022297u, vdimethylarginineESTs, Highly similar to DDH1_HUMANdimethylaminohydrolase 1NG, NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1[H. sapiens], ESTs, Weakly similar todimethylargininedimethylaminohydrolase 1; NG, NGdimethylargininedimethylaminohydrolase [Rattusnorvegicus] [R. norvegicus],dimethylargininedimethylaminohydrolase 1,dimethylargininedimethylaminohydrolase 27747785AI008758jj, kkdipeptidylpeptidase 4,ESTs, Weakly similar to DPP4 MOUSEdipeptidylpeptidase IV (CD26,DIPEPTIDYL PEPTIDASE IVadenosine deaminase[M. musculus], ESTs, Weakly similar tocomplexing protein 2)DPP4_RAT Dipeptidyl peptidase IV(DPP IV) (GP110 glycoprotein) (Bilecanaliculus domain-specific membraneglycoprotein) [R. norvegicus],dipeptidylpeptidase 4,dipeptidylpeptidase 8, fibroblastactivation protein, fibroblast activationprotein, alpha1536054AA818658p, q, ee,diphtheria toxin receptordiphtheria toxin receptor (heparin-ff(heparin-binding epidermalbinding epidermal growth factor-likegrowth factor-like growthgrowth factor), heparin binding epidermalfactor), heparin bindinggrowth factor-like growth factorepidermal growth factor-likegrowth factor1833223NM_012945a, p, q,diphtheria toxin receptordiphtheria toxin receptor (heparin-ee, ff(heparin-binding epidermalbinding epidermal growth factor-likegrowth factor-like growthgrowth factor), heparin binding epidermalfactor), heparin bindinggrowth factor-like growth factorepidermal growth factor-likegrowth factor17961952NM_012788ggdiscs, large (Drosophila)Mus musculus mRNA for mDLG6B,homolog 1, discs, largecomplete cds, discs, large (Drosophila)homolog 1 (Drosophila)homolog 1, discs, large (Drosophila)homolog 5, discs, large homolog 1(Drosophila), discs, large homolog 5(Drosophila), guanylate kinase 1195124106NM_017141s, t, bbDNA polymerase beta,Mus musculus, Similar to DNApolymerase (DNA directed),polymerase beta, clone MGC: 6386betaIMAGE: 3581916, mRNA, complete cds,polymerase (DNA directed), beta195124107NM_017141llDNA polymerase beta,Mus musculus, Similar to DNApolymerase (DNA directed),polymerase beta, clone MGC: 6386betaIMAGE: 3581916, mRNA, complete cds,polymerase (DNA directed), beta165218686D00729g, hhdodecenoyl-Coenzyme Adodecenoyl-Coenzyme A deltadelta isomerase (3,2 trans-isomerase (3,2 trans-enoyl-Coenyme Aenoyl-Coenyme Aisomerase), dodecenoyl-Coenzyme Aisomerase), dodecenoyl-delta isomerase (3,2 trans-enoyl-Coenzyme A delta isomeraseCoenzyme A isomerase)(3,2 trans-enoyl-Coenzyme Aisomerase)199918687NM_017306hhdodecenoyl-Coenzyme Adodecenoyl-Coenzyme A deltadelta isomerasUGATINGENZYME E2-17 KD[M. musculus], RIKEN cDNA2610301N02 gene, cell division cycle 34,expressed sequence AI327276, ubiquitin-conjugating enzyme E2B, RAD6homology (S. cerevisiae), ubiquitin-conjugating enzyme E2C170213682L38482ecell division cycle 34ESTs, Highly similar to A41222 ubiquitin-protein ligase [H. sapiens], ESTs, Weaklysimilar to UBC2_HUMAN UBIQUITIN-CONJUGATING ENZYME E2-17 KD[M. musculus], RIKEN cDNA2610301N02 gene, cell division cycle 34,expressed sequence AI327276, ubiquitin-conjugating enzyme E2B, RAD6homology (S. cerevisiae), ubiquitin-conjugating enzyme E2C142322845AI227887e, aa, bbcell division cycle 42 (GTPRIKEN cDNA 4930544G11 gene, RIKENbinding protein, 25 kD), cellcDNA 5830400A04 gene, cell divisiondivision cycle 42 homolog (S.cycle 42 (GTP binding protein, 25 kD),cerevisiae)plysia ras-related homolog A2, rashomolog 9 (RhoC), ras homolog A2, rashomolog gene family, member C174116520NM_012532cceruloplasmin, ceruloplasminDNA segment, Chr 3, ERATO Doi 555,(ferroxidase)expressed, EST, Highly similar toFA8_HUMAN COAGULATION FACTORVIII PRECURSOR [H. sapiens], ESTs,Weakly similar to CERU MOUSECERULOPLASMIN PRECURSOR[M. musculus], ESTs, Weakly similar toCERU_RAT CERULOPLASMINPRECURSOR (FERROXIDASE)[R. norvegicus], ESTs, Weakly similar toKUHU ferroxidase [H. sapiens],ceruloplasmin, ceruloplasmin(ferroxidase), coagulation factor VIII,procoagulant component (hemophilia A)232119048NM_031719jj, kkchloride channel, nucleotide-chloride channel, nucleotide-sensitive,sensitive, 1A1A23291182NM_031790b, l, mcitron, citron (rho-interacting,EST, Highly similar to CTRO_HUMANserine/threonine kinase 21)CITRON PROTEIN [H. sapiens], ESTs,Highly similar to CTRO_HUMANCITRON PROTEIN [H. sapiens],KIAA0451 gene product, Nef-associatedfactor 1, citron, citron (rho-interacting,serine/threonine kinase 21)234417075NM_031974ggclathrin, light polypeptideH. sapiens clathrin light chain a gene,(Lca)clathrin, light polypeptide (Lca), clathrin,light polypeptide (Lcb), expressedsequence AV02655621613627AA851493aa, bbclaudin 7ESTs, Weakly similar to CLD7_RATCLAUDIN-7 [R. norvegicus], Musmusculus claudin 19 mRNA, completecds, claudin 10, claudin 15, claudin 7195215364NM_017147iicofilin 1 (non-muscle), cofilincofilin 1 (non-muscle), cofilin 1, non-1, non-musclemuscle, cofilin 2 (muscle), cofilin 2,muscle, expressed sequence AW987265195215365NM_017147aa, bb, llcofilin 1 (non-muscle), cofilincofilin 1 (non-muscle), cofilin 1, non-1, non-musclemuscle, cofilin 2 (muscle), cofilin 2,muscle, expressed sequence AW987265165916610D28557c, f, u, vcold shock domain protein AMus musculus 10 days embryo wholebody cDNA, RIKEN full-length enrichedlibrary, clone: 2610205I19: Y box protein1, full insert sequence, Mus musculus Y-box binding protein (oxyR) mRNA, partialcds, cold shock domain protein A148515572AI231472f, gcollagen, type I, alpha 1,EST, Weakly similar to CA11_HUMANprocollagen, type I, alpha 1COLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], EST, Weaklysimilar to PROCOLLAGEN ALPHA 1(I)CHAIN PRECURSOR [M. musculus],ESTs, Weakly similar to CA11_HUMANCOLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], ESTs,Weakly similar to PROCOLLAGENALPHA 1(I) CHAIN PRECURSOR[M. musculus], F-box only protein 29,Mus musculus, Similar to RIKEN cDNA1700051I12 gene, clone MGC: 28741IMAGE: 4481590, mRNA, complete cds,collagen, type IV, alpha 3 (Goodpastureantigen), expressed sequenceAW742721, procollagen, type I, alpha 1,procollagen, type IV, alpha 1,procollagen, type IV, alpha 4,procollagen, type IV, alpha 5,procollagen, type VI, alpha 1, putativeemu1171315571M27207gcollagen, type I, alpha 1,EST, Weakly similar to CA11_HUMANprocollagen, type I, alpha 1COLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], EST, Weaklysimilar to PROCOLLAGEN ALPHA 1(I)CHAIN PRECURSOR [M. musculus],ESTs, Weakly similar to CA11_HUMANCOLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], ESTs,Weakly similar to PROCOLLAGENALPHA 1(I) CHAIN PRECURSOR[M. musculus], F-box only protein 29,Mus musculus, Similar to RIKEN cDNA1700051I12 gene, clone MGC: 28741IMAGE: 4481590, mRNA, complete cds,collagen, type IV, alpha 3 (Goodpastureantigen), expressed sequenceAW742721, procollagen, type I, alpha 1,procollagen, type IV, alpha 1,procollagen, type IV, alpha 4,procollagen, type IV, alpha 5,procollagen, type VI, alpha 1, putativeemu1269615569Z78279c, g, bbcollagen, type I, alpha 1,EST, Weakly similar to CA11_HUMANprocollagen, type I, alpha 1COLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], EST, Weaklysimilar to PROCOLLAGEN ALPHA 1(I)CHAIN PRECURSOR [M. musculus],ESTs, Weakly similar to CA11_HUMANCOLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], ESTs,Weakly similar to PROCOLLAGENALPHA 1(I) CHAIN PRECURSOR[M. musculus], F-box only protein 29,Mus musculus, Similar to RIKEN cDNA1700051I12 gene, clone MGC: 28741IMAGE: 4481590, mRNA, complete cds,collagen, type IV, alpha 3 (Goodpastureantigen), expressed sequenceAW742721, procollagen, type I, alpha 1,procollagen, type IV, alpha 1,procollagen, type IV, alpha 4,procollagen, type IV, alpha 5,procollagen, type VI, alpha 1, putativeemu1269615570Z78279c, f, g, j, kcollagen, type I, alpha 1,EST, Weakly similar to CA11_HUMANprocollagen, type I, alpha 1COLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], EST, Weaklysimilar to PROCOLLAGEN ALPHA 1(I)CHAIN PRECURSOR [M. musculus],ESTs, Weakly similar to CA11_HUMANCOLLAGEN ALPHA 1(I) CHAINPRECURSOR [H. sapiens], ESTs,Weakly similar to PROCOLLAGENALPHA 1(I) CHAIN PRECURSOR[M. musculus], F-box only protein 29,Mus musculus, Similar to RIKEN cDNA1700051I12 gene, clone MGC: 28741IMAGE: 4481590, mRNA, complete cds,collagen, type IV, alpha 3 (Goodpastureantigen), expressed sequenceAW742721, procollagen, type I, alpha 1,procollagen, type IV, alpha 1,procollagen, type IV, alpha 4,procollagen, type IV, alpha 5,procollagen, type VI, alpha 1, putativeemu126153AA875531g, j, kcollagen, type I, alpha 2,EST, Moderately similar to 0806162Bprocollagen, type I, alpha 2cytochrome b [M. musculus], EST,Moderately similar to 810024Bcytochrome b [H. sapiens], EST, Weaklysimilar to 0806162B cytochrome b[M. musculus], EST, Weakly similar to0812187A cytochrome b [Rattusnorvegicus] [R. norvegicus], EST, Weaklysimilar to 810024M URF 6 [H. sapiens], F-box only protein 29, Mus musculus,clone IMAGE: 5323568, mRNA, partialcds, collagen, type VI, alpha 3,procollagen, type I, alpha 2, prostatetumor over expressed gene 1,retinoblastoma binding protein 12336158AA859284f, gcollagen, type I, alpha 2,F-box only protein 29, Mus musculus,procollagen, type I, alpha 2clone IMAGE: 5323568, mRNA, partialcds, collagen, type VI, alpha 3,procollagen, type I, alpha 2, prostatetumor over expressed gene 1,retinoblastoma binding protein 123766154NM_053356f, gcollagen, type I, alpha 2,F-box only protein 29, Mus musculus,procollagen, type I, alpha 2clone IMAGE: 5323568, mRNA, partialcds, collagen, type VI, alpha 3,procollagen, type I, alpha 2, prostatetumor over expressed gene 1,retinoblastoma binding protein 123766155NM_053356gcollagen, type I, alpha 2,F-box only protein 29, Mus musculus,procollagen, type I, alpha 2clone IMAGE: 5323568, mRNA, partialcds, collagen, type VI, alpha 3,procollagen, type I, alpha 2, prostatetumor over expressed gene 1,retinoblastoma binding protein 123766156NM_053356gcollagen, type I, alpha 2,F-box only protein 29, Mus musculus,procollagen, type I, alpha 2clone IMAGE: 5323568, mRNA, partialcds, collagen, type VI, alpha 3,procollagen, type I, alpha 2, prostatetumor over expressed gene 1,retinoblastoma binding protein 123766157NM_053356f, gcollagen, type I, alpha 2,F-box only protein 29, Mus musculus,procollagen, type I, alpha 2clone IMAGE: 5323568, mRNA, partialcds, collagen, type VI, alpha 3,procollagen, type I, alpha 2, prostatetumor over expressed gene 1,retinoblastoma binding protein 1171116427M21354f, gcollagen, type III, alpha 1EST, Highly similar to CA13_HUMAN(Ehlers-Danlos syndromeCOLLAGEN ALPHA 1(III) CHAINtype IV, autosomal dominant),PRECURSOR [H. sapiens], EST,procollagen, type III, alpha 1Moderately similar to CA13_HUMANCOLLAGEN ALPHA 1(III) CHAINPRECURSOR [H. sapiens], EST, Weaklysimilar to CA13 MOUSE COLLAGENALPHA 1(III) CHAIN PRECURSOR[M. musculus], EST, Weakly similar toCA13_HUMAN COLLAGEN ALPHA 1(III)CHAIN PRECURSOR [H. sapiens],ESTs, Weakly similar to CA13 MOUSECOLLAGEN ALPHA 1(III) CHAINPRECURSOR [M. musculus], ESTs,Weakly similar to S41067 collagen alpha1(III) chain - rat [R. norvegicus], Musmusculus, Similar to putative proteinphosphatase 1 nuclear targeting subunit,clone IMAGE: 3157989, mRNA, partialcds, RIKEN cDNA 2010011D20 gene,cleavage and polyadenylation specificfactor 6, 68 kD subunit, collagen type V,alpha 2, collagen, type III, alpha 1(Ehlers-Danlos syndrome type IV,autosomal dominant), procollagen, typeIII, alpha 1267416426X70369c, g, bbcollagen, type III, alpha 1EST, Highly similar to CA13_HUMAN(Ehlers-Danlos syndromeCOLLAGEN ALPHA 1(III) CHAINtype IV, autosomal dominant),PRECURSOR [H. sapiens], EST,procollagen, type III, alpha 1Moderately similar to CA13_HUMANCOLLAGEN ALPHA 1(III) CHAINPRECURSOR [H. sapiens], EST, Weaklysimilar to CA13 MOUSE COLLAGENALPHA 1(III) CHAIN PRECURSOR[M. musculus], EST, Weakly similar toCA13_HUMAN COLLAGEN ALPHA 1(III)CHAIN PRECURSOR [H. sapiens],ESTs, Weakly similar to CA13 MOUSECOLLAGEN ALPHA 1(III) CHAINPRECURSOR [M. musculus], ESTs,Weakly similar to S41067 collagen alpha1(III) chain - rat [R. norvegicus], Musmusculus, Similar to putative proteinphosphatase 1 nuclear targeting subunit,clone IMAGE: 3157989, mRNA, partialcds, RIKEN cDNA 2010011D20 gene,cleavage and polyadenylation specificfactor 6, 68 kD subunit, collagen type V,alpha 2, collagen, type III, alpha 1(Ehlers-Danlos syndrome type IV,autosomal dominant), procollagen, typeIII, alpha 12512262AA859757hhcollagen, type V, alpha 1,EST, Weakly similar to CGHU1Vprocollagen, type V, alpha 1collagen alpha 1(V) chain precursor[H. sapiens], Homo sapiens cDNAFLJ30442 fis, clone BRACE2009212,Homo sapiens proline-rich acidic proteinmRNA, complete cds, Mus musculus,clone IMAGE: 3490511, mRNA, partialcds, collagen, type V, alpha 1, collagen,type XI, alpha 1, endoplasmic reticulumchaperone SIL1, homolog of yeast,hypothetical protein MGC2705,procollagen, type V, alpha 1,procollagen, type V, alpha 3,procollagen, type XI, alpha 1254425237NM_134452rcollagen, type V, alpha 1,EST, Weakly similar to CGHU1Vprocollagen, type V, alpha 1collagen alpha 1(V) chain precursor[H. sapiens], Homo sapiens cDNAFLJ30442 fis, clone BRACE2009212,Homo sapiens proline-rich acidic proteinmRNA, complete cds, Mus musculus,clone IMAGE: 3490511, mRNA, partialcds, collagen, type V, alpha 1, collagen,type XI, alpha 1, endoplasmic reticulumchaperone SIL1, homolog of yeast,hypothetical protein MGC2705,procollagen, type V, alpha 1,procollagen, type V, alpha 3,procollagen, type XI, alpha 1139915438AI179399e, gcollagen, type V, alpha 2,EST, Weakly similar to CGHU2Vprocollagen, type V, alpha 2collagen alpha 2(V) chain precursor[H. sapiens], EST, Weakly similar toI49607 procollagen type V alpha 2 -mouse [M. musculus], ESTs, Weaklysimilar to I49607 procollagen type Valpha 2 - mouse [M. musculus], ESTs,Weakly similar to S41067 collagen alpha1(III) chain - rat [R. norvegicus], Musmusculus, Similar to putative proteinphosphatase 1 nuclear targeting subunit,clone IMAGE: 3157989, mRNA, partialcds, RIKEN cDNA 2810002D19 gene,collagen, type V, alpha 2, procollagen,type III, alpha 1, procollagen, type V,alpha 2205021443NM_019262kk, IIcomplement component 1, qsubcomponent, betapolypeptide205021444NM_019262jj, kkcomplement component 1, qsubcomponent, betapolypeptide23041727NM_031642jj, kkcore promoter elementDNA segment, Chr 12, ERATO Doi 427,binding proteinexpressed, EST, Moderately similar tocore promoter element binding protein[Rattus norvegicus] [R. norvegicus],ESTs, Weakly similar to core promoterelement binding protein [Rattusnorvegicus] [R. norvegicus], Kruppel-likefactor 7 (ubiquitous), core promoterelement binding protein204015347NM_019222IIcoronin, actin binding proteinESTs, Moderately similar to CO1B_RAT1B, coronin, actin-bindingCoronin 1B (Coronin 2) [R. norvegicus],protein, 1Bcoronin 6, coronin, actin binding protein1B, coronin, actin binding protein 1C,coronin, actin binding protein, 1C,hypothetical protein DKFZp762I16617394467NM_012529f, gcreatine kinase, brain17394468NM_012529gcreatine kinase, brain174220357NM_012534cc, ddcrystallin, alpha Acrystallin, alpha A, expressed sequenceAI323437182913723NM_012935aa, bbcrystallin, alpha BESTs, Moderately similar to T46637transcription factor 1, neural - rat[R. norvegicus], ESTs, Weakly similar toA35804 nucleolin [H. sapiens], ESTs,Weakly similar to alpha-crystallin chain B[M. musculus], Homo sapiens mRNA;cDNA DKFZp434E0922 (from cloneDKFZp434E0922), Mus musculus 10, 11days embryo whole body cDNA, RIKENfull-length enriched library,clone: 2810003I18: myelin transcriptionfactor 1-like, full insert sequence,crystallin, alpha B, myelin transcriptionfactor 1-like, nucleolin1830487NM_012937ncrystallin, beta B2EST, Highly similar to CRB2_MOUSEBETA CRYSTALLIN B2 (BP)[R. norvegicus], EST, Weakly similar to AChain A, The N-Terminal Domain OfBeta-B2-Crystallin Resembles ThePutative Ancestral Homodimer[M. musculus], Homo sapiens, cloneIMAGE: 3542716, mRNA, partial cds,crystallin, beta B223128844NM_031690bcrystallin, beta B3absent in melanoma 1, absent inmelanoma 1-like, crystallin, beta B3203518572NM_019201n, oC-terminal binding protein 1C-terminal binding protein 1, Homosapiens mRNA; cDNA DKFZp434B0914(from clone DKFZp434B0914); partialcds203518573NM_019201f, gC-terminal binding protein 1C-terminal binding protein 1, Homosapiens mRNA; cDNA DKFZp434B0914(from clone DKFZp434B0914); partialcds165725041D14014fcyclin D1, cyclin D1 (PRAD1:EST, Moderately similar to JC2342 cyclinparathyroid adenomatosis 1)D1 - rat [R. norvegicus], cyclin D1, cyclinD1 (PRAD1: parathyroid adenomatosis1)267724232X75207aa, bbcyclin D1, cyclin D1 (PRAD1:EST, Moderately similar to JC2342 cyclinparathyroid adenomatosis 1)D1 - rat [R. norvegicus], cyclin D1, cyclinD1 (PRAD1: parathyroid adenomatosis1)182520757NM_012923cc, ddcyclin G, cyclin G1ESTs, Weakly similar to CGG1_RATCyclin G1 (Cyclin G) [R. norvegicus],cyclin G, cyclin G2, cyclin I146814430AI230798rcyclin-dependent kinasecyclin-dependent kinase inhibitor 3inhibitor 3 (CDK2-associated(CDK2-associated dual specificitydual specificity phosphatase)phosphatase)18042853NM_012838n, ocystatin B, cystatin B (stefincystatin B, cystatin B (stefin B)B)148224327AI231292ggcystatin C, cystatin CESTs, Moderately similar to CYTC(amyloid angiopathy andMOUSE CYSTATIN C PRECURSORcerebral hemorrhage)[M. musculus], ESTs, Weakly similar toCYTC MOUSE CYSTATIN CPRECURSOR [M. musculus], RIKENcDNA 1110017E11 gene, RIKEN cDNA9230101F08 gene, cystatin C, cystatin C(amyloid angiopathy and cerebralhemorrhage), cystatin D, cystatin S,cystatin SA, cystatin SN24831892NM_057144a, o, x,cysteine and glycine-richRIKEN cDNA 1200007O21 gene,ee, ff, kkprotein 3 (cardiac LIMcysteine and glycine-rich protein 3protein), cysteine-rich protein 3(cardiac LIM protein), cysteine-richprotein 3196814694NM_017202aacytochrome c oxidase subunitEST, Weakly similar to COX4_HUMANIV isoform 1, cytochrome cCYTOCHROME C OXIDASEoxidase, subunit IVaPOLYPEPTIDE IV PRECURSO[H. sapiens], ESTs, Moderately similar toCOX4_HUMAN CYTOCHROME COXIDASE POLYPEPTIDE IVPRECURSO [H. sapiens], cytochrome coxidase subunit IV isoform 1,cytochrome c oxidase, subunit IVa238321866NM_053472u, vcytochrome c oxidase subunitcytochrome c oxidase subunit IV isoformIV isoform 2, cytochrome c2, cytochrome c oxidase, subunit IVboxidase, subunit IVb113823574AI104520hhcytochrome c oxidase subunitVla polypeptide 1,cytochrome c oxidase,subunit VI a, polypeptide 1174320704NM_012541aa, bbcytochrome P450, 1a2,cytochrome P450, 1a2, aromaticaromatic compound inducible,compound inducible, cytochrome P450,cytochrome P450, subfamily Isubfamily I (aromatic compound-(aromatic compound-inducible), polypeptide 2inducible), polypeptide 21831190NM_012940j, kcytochrome P450, 1b1,cytochrome P450, 1b1,benz[a]anthracene inducible,benz[a]anthracene inducible,cytochrome P450, subfamily Icytochrome P450, subfamily I (dioxin-(dioxin-inducible), polypeptideinducible), polypeptide 1 (glaucoma 3,1 (glaucoma 3, primaryprimary infantile)infantile)22814010NM_031543u, vcytochrome P450, 2e1,ethanol inducible, cytochromeP450, subfamily IIE (ethanol-inducible)22814011NM_031543vcytochrome P450, 2e1,ethanol inducible, cytochromeP450, subfamily IIE (ethanol-inducible)183220928NM_012941l, mcytochrome P450, 51,cytochrome P450, 51, cytochrome P450,cytochrome P450, 5151 (lanosterol 14-alpha-demethylase)(lanosterol 14-alpha-demethylase)170820714M14972s, tcytochrome P450, subfamilyEST, Moderately similar to I65981 fattyIV B, polypeptide 1,acid omega-hydroxylase [H. sapiens],cytochrome P450, subfamilyMus musculus, Similar to cytochromeIVB, polypeptide 1P450, 4a10, clone MGC: 18880IMAGE: 4237837, mRNA, complete cds,Mus musculus, Similar to cytochromeP450, 4a10, clone MGC: 25972IMAGE: 4240359, mRNA, complete cds,RIKEN cDNA A230105L22 gene,cytochrome P450, 4a10, cytochromeP450, subfamily IVA, polypeptide 11,expressed sequence AI314743190920921NM_016999s, tcytochrome P450, subfamilyEST, Moderately similar to I65981 fattyIV B, polypeptide 1,acid omega-hydroxylase [H. sapiens],cytochrome P450, subfamilyMus musculus, Similar to cytochromeIVB, polypeptide 1P450, 4a10, clone MGC: 18880IMAGE: 4237837, mRNA, complete cds,Mus musculus, Similar to cytochromeP450, 4a10, clone MGC: 25972IMAGE: 4240359, mRNA, complete cds,RIKEN cDNA A230105L22 gene,cytochrome P450, 4a10, cytochromeP450, subfamily IVA, polypeptide 11,expressed sequence AI31474317441762NM_012543fD site albumin promoterD site albumin promoter binding protein,binding protein, D site ofD site of albumin promoter (albumin D-albumin promoter (albumin D-box) binding protein, RIKEN cDNAbox) binding protein2310028D20 gene17441763NM_012543hhD site albumin promoterD site albumin promoter binding protein,binding protein, D site ofD site of albumin promoter (albumin D-albumin promoter (albumin D-box) binding protein, RIKEN cDNAbox) binding protein2310028D20 gene217417226NM_024131b, c, u, vD-dopachrome tautomeraseD-dopachrome tautomerase, EST,Moderately similar to DOPD_HUMAN D-DOPACHROME TAUTOMERASE[H. sapiens]217417227NM_024131cD-dopachrome tautomeraseD-dopachrome tautomerase, EST,Moderately similar to DOPD_HUMAN D-DOPACHROME TAUTOMERASE[H. sapiens]269118352Z12298aa, bbdecorinRIKEN cDNA 5530600M07 gene,decorin, expressed sequence C85409,extracellular matrix protein 2, femaleorgan and adipocyte specific22601638NM_031143d, e, ii,diacylglycerol kinase zeta,EST, Weakly similar to diacylglycerolkkdiacylglycerol kinase, zetakinase zeta [Rattus norvegicus](104 kD)[R. norvegicus], ESTs, Highly similar toKDGA MOUSE DIACYLGLYCEROLKINASE, ALPHA [M. musculus], ESTs,Weakly similar to diacylglycerol kinase[Rattus norvegicus] [R. norvegicus],ESTs, Weakly similar to KDGA MOUSEDIACYLGLYCEROL KINASE, ALPHA[M. musculus], diacylglycerol kinase,alpha (80 kDa), diacylglycerol kinase,gamma 3, diacylglycerol kinase, iota,diacylglycerol kinase, zeta (104 kD)119424AA850922h, ldimethylarginineESTs, Highly similar to DDH1_HUMANdimethylaminohydrolase 1NG, NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1[H. sapiens], ESTs, Weakly similar todimethylargininedimethylaminohydrolase 1; NG, NGdimethylargininedimethylaminohydrolase [Rattusnorvegicus] [R. norvegicus],dimethylargininedimethylaminohydrolase 1,dimethylargininedimethylaminohydrolase 2319421AA945152bbdimethylarginineESTs, Highly similar to DDH1_HUMANdimethylaminohydrolase 1NG, NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1[H. sapiens], ESTs, Weakly similar todimethylargininedimethylaminohydrolase 1; NG, NGdimethylargininedimethylaminohydrolase [Rattusnorvegicus] [R. norvegicus],dimethylargininedimethylaminohydrolase 1,dimethylargininedimethylaminohydrolase 2210419423NM_022297u, vdimethylarginineESTs, Highly similar to DDH1_HUMANdimethylaminohydrolase 1NG, NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1[H. sapiens], ESTs, Weakly similar todimethylargininedimethylaminohydrolase 1; NG, NGdimethylargininedimethylaminohydrolase [Rattusnorvegicus] [R. norvegicus],dimethylargininedimethylaminohydrolase 1,dimethylargininedimethylaminohydrolase 27747785AI008758jj, kkdipeptidylpeptidase 4,ESTs, Weakly similar to DPP4 MOUSEdipeptidylpeptidase IV (CD26,DIPEPTIDYL PEPTIDASE IVadenosine deaminase[M. musculus], ESTs, Weakly similar tocomplexing protein 2)DPP4_RAT Dipeptidyl peptidase IV(DPP IV) (GP110 glycoprotein) (Bilecanaliculus domain-specific membraneglycoprotein) [R. norvegicus],dipeptidylpeptidase 4,dipeptidylpeptidase 8, fibroblastactivation protein, fibroblast activationprotein, alpha1536054AA818658p, q, ee,diphtheria toxin receptordiphtheria toxin receptor (heparin-ff(heparin-binding epidermalbinding epidermal growth factor-likegrowth factor-like growthgrowth factor), heparin binding epidermalfactor), heparin bindinggrowth factor-like growth factorepidermal growth factor-likegrowth factor1833223NM_012945a, p, q,diphtheria toxin receptordiphtheria toxin receptor (heparin-ee, ff(heparin-binding epidermalbinding epidermal growth factor-likegrowth factor-like growthgrowth factor), heparin binding epidermalfactor), heparin bindinggrowth factor-like growth factorepidermal growth factor-likegrowth factor17961952NM_012788ggdiscs, large (Drosophila)Mus musculus mRNA for mDLG6B,homolog 1, discs, largecomplete cds, discs, large (Drosophila)homolog 1 (Drosophila)homolog 1, discs, large (Drosophila)homolog 5, discs, large homolog 1(Drosophila), discs, large homolog 5(Drosophila), guanylate kinase 1195124106NM_017141s, t, bbDNA polymerase beta,Mus musculus, Similar to DNApolymerase (DNA directed),polymerase beta, clone MGC: 6386betaIMAGE: 3581916, mRNA, complete cds,polymerase (DNA directed), beta195124107NM_017141llDNA polymerase beta,Mus musculus, Similar to DNApolymerase (DNA directed),polymerase beta, clone MGC: 6386betaIMAGE: 3581916, mRNA, complete cds,polymerase (DNA directed), beta165218686D00729g, hhdodecenoyl-Coenzyme Adodecenoyl-Coenzyme A deltadelta isomerase (3,2 trans-isomerase (3,2 trans-enoyl-Coenyme Aenoyl-Coenyme Aisomerase), dodecenoyl-Coenzyme Aisomerase), dodecenoyl-delta isomerase (3,2 trans-enoyl-Coenzyme A delta isomeraseCoenzyme A isomerase)(3,2 trans-enoyl-Coenzyme Aisomerase)199918687NM_017306hhdodecenoyl-Coenzyme Adodecenoyl-Coenzyme A deltadelta isomerase (3,2 trans-isomerase (3,2 trans-enoyl-Coenyme Aenoyl-Coenyme Aisomerase), dodecenoyl-Coenzyme Aisomerase), dodecenoyl-delta isomerase (3,2 trans-enoyl-Coenzyme A delta isomeraseCoenzyme A isomerase)(3,2 trans-enoyl-Coenzyme Aisomerase)1950492NM_017140l, m, n,dopamine receptor 3,dopamine receptor 3, dopamine receptoraadopamine receptor D3D322181719NM_031024jj, kkdrebrin 1drebrin 1242715996NM_053769cc, dddual specificity phosphataseMus musculus, clone MGC: 117031, protein tyrosineIMAGE: 3964527, mRNA, complete cds,phosphatase, non-receptorRIKEN cDNA 2310076D10 gene, RIKENtype 16cDNA 4930527G07 gene, dualspecificity phosphatase 1, expressedsequence BB104621, protein tyrosinephosphatase, non-receptor type 16179724113NM_012791edual-specificity tyrosine-(Y)-ESTs, Moderately similar to DYRA_RATphosphorylation regulatedDual-specificity tyrosine-phosphorylationkinase 1A, dual-specificityregulated kinase 1A (Protein kinasetyrosine-(Y)-phosphorylationminibrain homolog) (MNBH) (RP86)regulated kinase 1a(Dual specificity YAK1-related kinase)[R. norvegicus], ESTs, Weakly similar toDYRK MOUSE DUAL-SPECIFICITYTYROSINE-(Y)-PHOSPHORYLATIONREGULATED KINASE [M. musculus],Mus musculus, clone MGC: 6699IMAGE: 3584001, mRNA, complete cds,dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A,dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a179718135NM_012791e, gg, lldual-specificity tyrosine-(Y)-ESTs, Moderately similar to DYRA_RATphosphorylation regulatedDual-specificity tyrosine-phosphorylationkinase 1A, dual-specificityregulated kinase 1A (Protein kinasetyrosine-(Y)-phosphorylationminibrain homolog) (MNBH) (RP86)regulated kinase 1a(Dual specificity YAK1-related kinase)[R. norvegicus], ESTs, Weakly similar toDYRK MOUSE DUAL-SPECIFICITYTYROSINE-(Y)-PHOSPHORYLATIONREGULATED KINASE [M. musculus],Mus musculus, clone MGC: 6699IMAGE: 3584001, mRNA, complete cds,dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A,dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a24151118NM_053655udynamin 1-likeESTs, Moderately similar to dynamin 2[Mus musculus] [M. musculus], Musmusculus, Similar to KIAA0820 protein,clone MGC: 37713 IMAGE: 5066120,mRNA, complete cds, Mus musculus,Similar to dynamin 1-like, cloneMGC: 41233 IMAGE: 1395338, mRNA,complete cds, dynamin 1-like, dynamin 218951693NM_013199ggdynamin 2ESTs, Highly similar to A53165 dynaminII isoform aa - rat [R. norvegicus], ESTs,Moderately similar to dynamin 2 [Musmusculus] [M. musculus], Mus musculus,Similar to KIAA0820 protein, cloneMGC: 37713 IMAGE: 5066120, mRNA,complete cds, Mus musculus,, Similar todynamin 1-like, clone MGC: 41233IMAGE: 1395338, mRNA, complete cds,RIKEN cDNA 1200011N24 gene,dynamin 21775425NM_012698hhdystrophin (musculardystrobrevin alpha, dystrobrevin, beta,dystrophy, Duchenne andutrophinBecker types), dystrophin,muscular dystrophy174623868NM_012551a, h, l, p,early growth response 1early growth response 1, expressedq, y, z,sequence AI835008ee, ff174623869NM_012551a, h, l, p,early growth response 1early growth response 1, expressedq, y, zsequence AI835008174623871NM_012551p, q, y, z,early growth response 1early growth response 1, expressediisequence AI835008174623872NM_012551p, q, y, zearly growth response 1early growth response 1, expressedsequence AI835008202016227NM_019137l, mearly growth response 4RIKEN cDNA 4930563M09 gene, earlygrowth response 4145023042AI230130s, t, iiectonucleoside triphosphateESTs, Weakly similar to CD39 MOUSEdiphosphohydrolase 2VASCULAR ATP-DIPHOSPHOHYDROLASE[M. musculus], RIKEN cDNA2010320H07 gene, ecto-apyrase,ectonucleoside triphosphatediphosphohydrolase 1, ectonucleosidetriphosphate diphosphohydrolase 3,lysosomal apyrase-like 124769528NM_057104rectonucleotideectonucleotidepyrophosphatase/phosphodiepyrophosphatase/phosphodiesterase 2,sterase 2, ectonucleotideectonucleotidepyrophosphatase/phosphodiepyrophosphatase/phosphodiesterase 2sterase 2 (autotaxin)(autotaxin)20671323NM_019371c, aa, bb,EGL nine homolog 3 (C.EGL nine homolog 3 (C. elegans), ESTs,iielegans), egl nine homolog 3Moderately similar to A53770 growth(C. elegans)factor-responsive protein, vascularsmooth muscle - rat [R. norvegicus],ESTs, Weakly similar to A53770 growthfactor-responsive protein, vascularsmooth muscle - rat [R. norvegicus], Musmusculus, Similar to EGL nine homolog3 (C. elegans), clone MGC: 36685IMAGE: 5371854, mRNA, complete cds,egl nine homolog 1 (C. elegans), eglnine homolog 3 (C. elegans)20671324NM_019371f, g, aa,EGL nine homolog 3 (C.EGL nine homolog 3 (C. elegans), ESTs,bb, kkelegans), egl nine homolog 3Moderately similar to A53770 growth(C. elegans)factor-responsive protein, vascularsmooth muscle - rat [R. norvegicus],ESTs, Weakly similar to A53770 growthfactor-responsive protein, vascularsmooth muscle - rat [R. norvegicus], Musmusculus, Similar to EGL nine homolog3 (C. elegans), clone MGC: 36685IMAGE: 5371854, mRNA, complete cds,egl nine homolog 1 (C. elegans), eglnine homolog 3 (C. elegans)214320925NM_022594g, hhenoyl Coenzyme A hydrataseEST, Moderately similar to Peroxisomal1, peroxisomal, enoylenoyl hydratase-like protein; enoylcoenzyme A hydratase 1,hydratase-like protein, peroxisomalperoxisomal[Rattus norvegicus] [R. norvegicus], enoylCoenzyme A hydratase 1, peroxisomal,enoyl coenzyme A hydratase 1,peroxisomal26442464X13411u, vEph receptor B2, EphB2EST, Highly similar to putative protein-tyrosine kinase [Homo sapiens][H. sapiens], Eph receptor B1, Ephreceptor B2, Eph receptor B3, EphB1,expressed sequence AW456895,expressed sequence AW4882551805338NM_012843repithelial membrane protein 1epithelial membrane protein 1180617541NM_012844c, depoxide hydrolase 1,epoxide hydrolase 1, microsomal,microsomal, epoxideepoxide hydrolase 1, microsomalhydrolase 1, microsomal(xenobiotic)(xenobiotic)236224420NM_033539jj, kk, lleukaryotic translationEST, Weakly similar to S21055elongation factor 1 alpha 2translation elongation factor eEF-1 alphachain - rat [R. norvegicus], ESTs, Highlysimilar to EFHU1 translation elongationfactor eEF-1 alpha-1 chain [H. sapiens],ESTs, Weakly similar to S21055translation elongation factor eEF-1 alphachain - rat [R. norvegicus], G1 to S phasetransition 1, G1 to phase transition 1, G1to phase transition 2, eukaryotictranslation elongation factor 1 alpha 1198017561NM_017245l, meukaryotic translationESTs, Highly similar to EF2_RATelongation factor 2Elongation factor 2 (EF-2)[R. norvegicus], ESTs, Weakly similar toEF2_MOUSE Elongation factor 2 (EF-2)[M. musculus], ESTs, Weakly similar toEF2_RAT Elongation factor 2 (EF-2)[R. norvegicus], G elongation factor, Musmusculus, Similar to elongation factorG2, clone MGC: 28160 IMAGE: 3984129,mRNA, complete cds, U5 small nuclearribonucleoprotein 116 kDa, U5 snRNP-specific protein, 116 kD, eukaryotictranslation elongation factor 2,expressed sequence AI451340198017563NM_017245h, leukaryotic translationESTs, Highly similar to EF2_RATelongation factor 2Elongation factor 2 (EF-2)[R. norvegicus], ESTs, Weakly similar toEF2_MOUSE Elongation factor 2 (EF-2)[M. musculus], ESTs, Weakly similar toEF2_RAT Elongation factor 2 (EF-2)[R. norvegicus], G elongation factor, Musmusculus, Similar to elongation factorG2, clone MGC: 28160 IMAGE: 3984129,mRNA, complete cds, U5 small nuclearribonucleoprotein 116 kDa, U5 snRNP-specific protein, 116 kD, eukaryotictranslation elongation factor 2,expressed sequence AI451340120623152AI169170reukaryotic translationESTs, Weakly similar to EUKARYOTICinitiation factor 4A, isoform 2INITIATION FACTOR 4A-II[M. musculus], eukaryotic translationinitiation factor 4A, isoform 2207518713NM_020075p, q, s, teukaryotic translationDNA segment, Chr 1, ERATO Doi 692,initiation factor 5expressed, ESTs, Highly similar toEUKARYOTIC TRANSLATIONINITIATION FACTOR 5 [R. norvegicus],KIAA1856 protein, eukaryotic translationinitiation factor 5207518715NM_020075ee, ffeukaryotic translationDNA segment, Chr 1, ERATO Doi 692,initiation factor 5expressed, ESTs, Highly similar toEUKARYOTIC TRANSLATIONINITIATION FACTOR 5 [R. norvegicus],KIAA1856 protein, eukaryotic translationinitiation factor 5218416476NM_024162aafatty acid binding protein 3,EST, Moderately similar to FABHmuscle and heart, fatty acidMOUSE FATTY ACID-BINDINGbinding protein 3, muscle andPROTEIN, HEART [M. musculus], fattyheart (mammary-derivedacid binding protein 3, muscle and heart,growth inhibitor)fatty acid binding protein 3, muscle andheart (mammary-derived growthinhibitor)43120985AA893242IIfatty acid Coenzyme A ligase,ESTs, Weakly similar to fatty acidlong chain 2, fatty-acid-Coenzyme A ligase, long chain 2; acetyl-Coenzyme A ligase, long-Coenzyme A synthetase; acetate-CoAchain 2ligase; acetyl-Coenzyme A synthetase 1(ADP forming); acetyl-CoA synthetase[Mus musculus] [M. musculus], Musmusculus, Similar to fatty-acid-Coenzyme A ligase, long-chain 6, cloneMGC: 28744 IMAGE: 4481949, mRNA,complete cds, Mus musculus, Similar tohypothetical protein FLJ20920, cloneMGC: 25878 IMAGE: 4210220, mRNA,complete cds, fatty acid Coenzyme Aligase, long chain 2, fatty acid CoenzymeA ligase, long chain 5, fatty-acid-Coenzyme A ligase, long-chain 1,gonadotropin-regulated long chain acyl-CoA synthetase, lipidosis-related proteinlipidosin43120986AA893242IIfatty acid Coenzyme A ligase,ESTs, Weakly similar to fatty acidlong chain 2, fatty-acid-Coenzyme A ligase, long chain 2; acetyl-Coenzyme A ligase, long-Coenzyme A synthetase; acetate-CoAchain 2ligase; acetyl-Coenzyme A synthetase 1(ADP forming); acetyl-CoA synthetase[Mus musculus] [M. musculus], Musmusculus, Similar to fatty-acid-Coenzyme A ligase, long-chain 6, cloneMGC: 28744 IMAGE: 4481949, mRNA,complete cds, Mus musculus, Similar tohypothetical protein FLJ20920, cloneMGC: 25878 IMAGE: 4210220, mRNA,complete cds, fatty acid Coenzyme Aligase, long chain 2, fatty acid CoenzymeA ligase, long chain 5, fatty-acid-Coenzyme A ligase, long-chain 1,gonadotropin-regulated long chain acyl-CoA synthetase, lipidosis-related proteinlipidosin97220983AI044900a, h, l,fatty acid Coenzyme A ligase,ESTs, Weakly similar to fatty acidee, ff, kklong chain 2, fatty-acid-Coenzyme A ligase, long chain 2; acetyl-Coenzyme A ligase, long-Coenzyme A synthetase; acetate-CoAchain 2ligase; acetyl-Coenzyme A synthetase 1(ADP forming); acetyl-CoA synthetase[Mus musculus] [M. musculus], Musmusculus, Similar to fatty-acid-Coenzyme A ligase, long-chain 6, cloneMGC: 28744 IMAGE: 4481949, mRNA,complete cds, Mus musculus, Similar tohypothetical protein FLJ20920, cloneMGC: 25878 IMAGE: 4210220, mRNA,complete cds, fatty acid Coenzyme Aligase, long chain 2, fatty acid CoenzymeA ligase, long chain 5, fatty-acid-Coenzyme A ligase, long-chain 1,gonadotropin-regulated long chain acyl-CoA synthetase, lipidosis-related proteinlipidosin166820984D90109IIfatty acid Coenzyme A ligase,ESTs, Weakly similar to fatty acidlong chain 2, fatty-acid-Coenzyme A ligase, long chain 2; acetyl-Coenzyme A ligase, long-Coenzyme A synthetase; acetate-CoAchain 2ligase; acetyl-Coenzyme A synthetase 1(ADP forming); acetyl-CoA synthetase[Mus musculus] [M. musculus], Musmusculus, Similar to fatty-acid-Coenzyme A ligase, long-chain 6, cloneMGC: 28744 IMAGE: 4481949, mRNA,complete cds, Mus musculus, Similar tohypothetical protein FLJ20920, cloneMGC: 25878 IMAGE: 4210220, mRNA,complete cds, fatty acid Coenzyme Aligase, long chain 2, fatty acid CoenzymeA ligase, long chain 5, fatty-acid-Coenzyme A ligase, long-chain 1,gonadotropin-regulated long chain acyl-CoA synthetase, lipidosis-related proteinlipidosin241013005NM_053623j, k, y, zfatty acid-Coenzyme A ligase,long chain 4, fatty-acid-Coenzyme A ligase, long-chain 4131910182AI176185p, q, ggFBJ osteosarcoma oncogene,FBJ murine osteosarcoma viralv-fos FBJ murineoncogene homolog B, FBJosteosarcoma viral oncogeneosteosarcoma oncogene, FBJhomologosteosarcoma oncogene B, v-fos FBJmurine osteosarcoma viral oncogenehomolog264110181X06769p, qFBJ osteosarcoma oncogene,FBJ murine osteosarcoma viralv-fos FBJ murineoncogene homolog B, FBJosteosarcoma viral oncogeneosteosarcoma oncogene, FBJhomologosteosarcoma oncogene B, v-fos FBJmurine osteosarcoma viral oncogenehomolog244020868NM_053843kkFc fragment of IgG, lowaffinity IIIa, receptor for(CD16), Fc receptor, IgG, lowaffinity III244020869NM_053843w, x, kkFc fragment of IgG, lowaffinity IIIa, receptor for(CD16), Fc receptor, IgG, lowaffinity III235912364NM_033351e, y, z,Fc fragment of IgG, receptor,Fc fragment of IgG, receptor, transporter,ee, fftransporter, alpha, Fcalpha, Fc receptor, IgG, alpha chainreceptor, IgG, alpha chaintransportertransporter235912365NM_033351eFc fragment of IgG, receptor,Fc fragment of IgG, receptor, transporter,transporter, alpha, Fcalpha, Fc receptor, IgG, alpha chainreceptor, IgG, alpha chaintransportertransporter194421662NM_017126a, ee, ffferredoxin 1ferredoxin 1, similar to RIKEN cDNAB230118G17 gene194421663NM_017126a, h, i, p,ferredoxin 1ferredoxin 1, similar to RIKEN cDNAq, y, z,B230118G17 geneee, ff21198211NM_022500jj, kkferritin light chain 1, ferritin,ESTs, Moderately similar to ferritin lightlight polypeptidechain 1 [Rattus norvegicus][R. norvegicus], ESTs, Moderately similarto FRL2 MOUSE FERRITIN LIGHTCHAIN 2 [M. musculus], RIKEN cDNA4933416E14 gene, ferritin light chain 1,ferritin light chain 2, ferritin, lightpolypeptide21198212NM_022500h, l, kk, llferritin light chain 1, ferritin,ESTs, Moderately similar to ferritin lightlight polypeptidechain 1 [Rattus norvegicus][R. norvegicus], ESTs, Moderately similarto FRL2 MOUSE FERRITIN LIGHTCHAIN 2 [M. musculus], RIKEN cDNA4933416E14 gene, ferritin light chain 1,ferritin light chain 2, ferritin, lightpolypeptide26008210S61960jj, kkferritin light chain 1, ferritin,ESTs, Moderately similar to ferritin lightlight polypeptidechain 1 [Rattus norvegicus][R. norvegicus], ESTs, Moderately similarto FRL2 MOUSE FERRITIN LIGHTCHAIN 2 [M. musculus], RIKEN cDNA4933416E14 gene, ferritin light chain 1,ferritin light chain 2, ferritin, lightpolypeptide17476477NM_012559zfibrinogen, gammapolypeptide17476478NM_012559y, zfibrinogen, gammapolypeptide209120177NM_021867d, jj, kkfibroblast growth factor 16fibroblast growth factor 16172913489M91599cc, ddfibroblast growth factorreceptor 420225618NM_019143s, tfibronectin 1EST, Highly similar to FIBRONECTINPRECURSOR [R. norvegicus], ESTs,Weakly similar to PROTEIN-TYROSINEPHOSPHATASE ETA PRECURSOR[M. musculus], fibronectin 120225622NM_019143n, ofibronectin 1EST, Highly similar to FIBRONECTINPRECURSOR [R. norvegicus], ESTs,Weakly similar to PROTEIN-TYROSINEPHOSPHATASE ETA PRECURSOR[M. musculus], fibronectin 120256451NM_019153f, gfibulin 513186782AI176170eFK506 binding protein 1AFK506 binding protein 10 (65 kDa),(12 kD), FK506 binding proteinFK506 binding protein 1A (12 kD), FK5061a (12 kDa)binding protein 1a (12 kDa), FK506binding protein 5, FK506 binding protein7 (23 kDa), FK506 binding protein8 (38 kDa)215524346NM_022701ggflotillin 1flotillin 1169625359L13202n, oforkhead box D3230918403NM_031677d, jj, kkfour and a half LIM domains 2EST, Weakly similar to four and a halfLIM domains 2 [Rattus norvegicus][R. norvegicus], activator of CREM intestis, four and a half LIM domains 2,four and a half LIM domains 3, vascularRab-GAP/TBC-containing24111228NM_053625j, kG elongation factor,mitochondrial elongationfactor G235823715NM_033237j, k, y, z,galaninjj, kk2496506NM_080586iigamma-aminobutyric acidgamma-aminobutyric acid (GABA) A(GABA) A receptor, gamma 1,receptor, gamma 2, gamma-gamma-aminobutyric acidaminobutyric acid (GABA-A) receptor,(GABA-A) receptor, subunitsubunit gamma 1gamma 11749482NM_012567s, tgap junction membranegap junction membrane channel proteinchannel protein alpha 1, gapalpha 1, gap junction protein, alpha 1,junction protein, alpha 1,43 kD (connexin 43)43 kD (connexin 43)20511143NM_019280w, xgap junction membranegap junction membrane channel proteinchannel protein alpha 5, gapalpha 5, gap junction protein, alpha 5,junction protein, alpha 5,40 kD (connexin 40)40 kD (connexin 40)203123481NM_019185aa, bbGATA binding protein 6GATA binding protein 5, GATA bindingprotein 619341383NM_017088llGDP dissociation inhibitor 1,GDP dissociation inhibitor 1, guanosineguanosine diphosphatediphosphate (GDP) dissociation inhibitor 2(GDP) dissociation inhibitor 1237418949NM_053345iigeneral transcription factor IIgeneral transcription factor II A, 2 (12 kDA, 2 (12 kD subunit), generalsubunit), general transcription factor IIA,transcription factor IIA, 22 (12 kD subunit)(12 kD subunit)1748619NM_012565l, m, n, oglucokinase, glucokinase(hexokinase 4, maturity onsetdiabetes of the young 2)22935496NM_031589a, ee, ffglucose-6-phosphatase,Mus musculus, Similar to solute carriertransport (glucose-6-family 37 (glycerol-3-phosphatephosphate) protein 1, glucose-transporter), member 1, clone6-phosphatase, transportMGC: 28167 IMAGE: 3985469, mRNA,protein 1complete cds, glucose-6-phosphatase,transport (glucose-6-phosphate) protein1, glucose-6-phosphatase, transportprotein 1, solute carrier family 37(glycerol-3-phosphate transporter),member 122935497NM_031589iiglucose-6-phosphatase,Mus musculus, Similar to solute carriertransport (glucose-6-family 37 (glycerol-3-phosphatephosphate) protein 1, glucose-transporter), member 1, clone6-phosphatase, transportMGC: 28167 IMAGE: 3985469, mRNA,protein 1complete cds, glucose-6-phosphatase,transport (glucose-6-phosphate) protein1, glucose-6-phosphatase, transportprotein 1, solute carrier family 37(glycerol-3-phosphate transporter),member 1259715693S56679aa, bbglutamate receptor,glutamate receptor, ionotropic, AMPA 1,ionotropic, AMPA 1,glutamate receptor, ionotropic, AMPA1glutamate receptor,(alpha 1)ionotropic, AMPA1 (alpha 1)191124676NM_017010aa, bbglutamate receptor,ionotropic, N-methyl D-aspartate 1, glutamatereceptor, ionotropic, NMDA1(zeta 1)192911152NM_017073c, s, t, kkglutamate-ammonia ligase(glutamine synthase),glutamine synthetase192911153NM_017073y, kkglutamate-ammonia ligase(glutamine synthase),glutamine synthetase199814004NM_017305aa, bbglutamate-cysteine ligase,glutamate-cysteine ligase , modifiermodifier subunit, glutamate-subunit, glutamate-cysteine ligase,cysteine ligase, modifiermodifier subunitsubunit5445206AA925755llglutaminaseESTs, Highly similar to GLSK RATGLUTAMINASE, KIDNEY ISOFORMPRECURSOR [R. norvegicus], ESTs,Moderately similar to GLSK_HUMANGLUTAMINASE, KIDNEY ISOFORM,MITOCHONDRIAL PRECURSOR (GLS)(L-GLUTAMINE AMIDOHYDROLASE)(K-GLUTAMINASE) [H. sapiens], Homosapiens glutaminase isoform Mprecursor, mRNA, complete cds,expressed sequence AI314027,glutaminase115023596AI105435bbglutaryl-Coenzyme Aexpressed sequence AI266902,dehydrogenaseexpressed sequence D17825, glutaryl-Coenzyme A dehydrogenase22021852NM_030826aa, ggglutathione peroxidase 1ESTs, Weakly similar to GSHC_RATGlutathione peroxidase (GSHPX-1)(Cellular glutathione peroxidase)[R. norvegicus], glutathione peroxidase 1,glutathione peroxidase 2, glutathioneperoxidase 2 (gastrointestinal)195817686NM_017165hhglutathione peroxidase 4,ESTs, Weakly similar to GSHH_RATglutathione peroxidase 4Phospholipid hydroperoxide glutathione(phospholipidperoxidase, mitochondrial precursorhydroperoxidase)(PHGPx) (GPX-4) [R. norvegicus], RIKENcDNA 2310016C16 gene, RIKEN cDNA3110050F08 gene, glutathioneperoxidase 4, glutathione peroxidase 4(phospholipid hydroperoxidase)191221013NM_017014bglutathione S-transferase M2(muscle), glutathione S-transferase, mu 21799961NM_012796gglutathione S-transferaseglutathione S-transferase theta 2,theta 2, glutathione S-glutathione S-transferase, theta 2transferase, theta 219108417NM_017008aaglyceraldehyde-3-phosphateESTs, Moderately similar to G3PdehydrogenaseMOUSE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE[M. musculus], Mus musculus 12 daysembryo head cDNA, RIKEN full-lengthenriched library,clone: 3000002C10: glyceraldehyde-3-phosphate dehydrogenase, full insertsequence, RIKEN cDNA 4930448K20gene, glyceraldehyde-3-phosphatedehydrogenase178425650NM_012736dglycerol phosphateMus musculus 10 days embryo wholedehydrogenase 1,body cDNA, RIKEN full-length enrichedmitochondrial, glycerol-3-library, clone: 2610001M21: glycerolphosphate dehydrogenase 2phosphate dehydrogenase 1,(mitochondrial)mitochondrial, full insert sequence,glycerol phosphate dehydrogenase 1,mitochondrial, glycerol-3-phosphatedehydrogenase 2 (mitochondrial)251319456NM_133298h, l, w, xglycoprotein (transmembrane)glycoprotein (transmembrane) nmbnmb25134048NM_133298h, l, n, o,glycoprotein (transmembrane)glycoprotein (transmembrane) nmbw, xnmb25134049NM_133298c, h, l, n,glycoprotein (transmembrane)glycoprotein (transmembrane) nmbo, w, xnmb14316756AA818089llglycyl-tRNA synthetaseglycyl-tRNA synthetase220321746NM_030828cglypican 1glypican 1201915975NM_019132iiGNAS (guanine nucleotideESTs, Moderately similar to S34421binding protein, alphaGTP-binding regulatory protein Gs alphastimulating) complex locus,chain [H. sapiens], GNAS (guanineGNAS complex locusnucleotide binding protein, alphastimulating) complex locus, GNAScomplex locus, RIKEN cDNA5530400H20 gene, Sang, XLas protein1221152X14848bbgolgi SNAP receptor complexHomo sapiens, Similar to golgi SNAPmember 1receptor complex member 1, cloneMGC: 13657 IMAGE: 4250494, mRNA,complete cds, golgi SNAP receptorcomplex member 1194120745NM_017113f, ggranulingranulin194120746NM_017113j, cc, dd,granulingranulingg2173352NM_024127p, qgrowth arrest and DNA-growth arrest and DNA-damage-damage-inducible 45 alpha,inducible 45 alpha, growth arrest andgrowth arrest and DNA-DNA-damage-inducible 45 beta, growthdamage-inducible, alphaarrest and DNA-damage-inducible, alpha2173353NM_024127q, ee, ff,growth arrest and DNA-growth arrest and DNA-damage-ggdamage-inducible 45 alpha,inducible 45 alpha, growth arrest andgrowth arrest and DNA-DNA-damage-inducible 45 beta, growthdamage-inducible, alphaarrest and DNA-damage-inducible, alpha2173354NM_024127p, q, ee,growth arrest and DNA-growth arrest and DNA-damage-ffdamage-inducible 45 alpha,inducible 45 alpha, growth arrest andgrowth arrest and DNA-DNA-damage-inducible 45 beta, growthdamage-inducible, alphaarrest and DNA-damage-inducible, alpha102617506AI070068p, qgrowth arrest and DNA-growth arrest and DNA-damage-damage-inducible, betainducible 45 beta, growth arrest andDNA-damage-inducible, alpha, growtharrest and DNA-damage-inducible, beta247325290NM_057100d, u, vgrowth arrest specific 6,ESTs, Highly similar to growth arrestgrowth arrest-specific 6specific 6 [Rattus norvegicus][R. norvegicus], growth arrest specific 6,growth arrest-specific 6230115767NM_031623aa, bb, jj,growth factor receptor boundamyloid beta (A4) precursor protein-kk, llprotein 14, growth factorbinding, family B, member 1 interactingreceptor-bound protein 14protein, growth factor receptor boundprotein 10, growth factor receptor boundprotein 14, growth factor receptor-boundprotein 10, growth factor receptor-boundprotein 1419021396NM_013222dgrowth factor, augmenter ofgrowth factor, augmenter of liverliver regeneration (ERV1regeneration (ERV1 homolog, S.homolog, S. cerevisiae),cerevisiae), growth factor, erv1 (S.growth factor, erv1 (S.cerevisiae)-like (augmenter of livercerevisiae)-like (augmenter ofregeneration)liver regeneration)81517524AI010568jj, kkgrowth hormone receptorgrowth hormone receptor193610886NM_017094iigrowth hormone receptorgrowth hormone receptor193610887NM_017094jj, kkgrowth hormone receptorgrowth hormone receptor193610888NM_017094e, r, hhgrowth hormone receptorgrowth hormone receptor2290942NM_031577ugrowth hormone releasinghormone18071249NM_012850u, vgrowth hormone releasinggrowth hormone releasing hormonehormone receptorreceptor2199862NM_024487hhGrpE-like 1, mitochondrial,GrpE-like proteincochaperone218715349NM_024356a, y, zGTP cyclohydrolase 1, GTPGTP cyclohydrolase 1, GTPcyclohydrolase 1 (dopa-cyclohydrolase 1 (dopa-responsiveresponsive dystonia)dystonia)218715353NM_024356j, k, y, z,GTP cyclohydrolase 1, GTPGTP cyclohydrolase 1, GTPiicyclohydrolase 1 (dopa-cyclohydrolase 1 (dopa-responsiveresponsive dystonia)dystonia)129619118AI175281hhguanidinoacetate N-expressed sequence AA571402,methyltransferase,guanidinoacetate N-methyltransferase,guanidinoacetate,guanidinoacetate methyltransferasemethyltransferase179816947NM_012793b, u, v, jj,guanidinoacetate N-expressed sequence AA571402,kkmethyltransferase,guanidinoacetate N-methyltransferase,guanidinoacetateguanidinoacetate methyltransferasemethyltransferase2220690NM_031034w, xguanine nucleotide bindingESTs, Moderately similar to guanineprotein (G protein) alpha 12,nucleotide binding protein (G protein)guanine nucleotide bindingalpha 12 [Rattus norvegicus]protein, alpha 12[R. norvegicus], guanine nucleotidebinding protein (G protein), alpha 13,guanine nucleotide binding protein,alpha 12, guanine nucleotide bindingprotein, alpha 13187019949NM_013106l, mguanine nucleotide bindingguanine nucleotide binding protein (Gprotein (G protein), alphaprotein), alpha inhibiting activityinhibiting activity polypeptidepolypeptide 3, guanine nucleotide3, guanine nucleotide bindingbinding protein, alpha inhibiting 3protein, alpha inhibiting 31392143AA817892rguanine nucleotide bindingESTs, Weakly similar to C Chain C, Apaf-protein (G protein), beta1 Card In Complex With Prodomain Ofpolypeptide 2, guanineProcaspase-9 {SUB 1-95 [H. sapiens],nucleotide binding protein,Homo sapiens mRNA expressed only inbeta 2placental villi, clone SMAP5, PWP2periodic tryptophan protein homolog(yeast), Rattus norvegicus guaninenucleotide binding protein beta 4 subunitmRNA, partial cds, guanine nucleotidebinding protein (G protein), betapolypeptide 2, guanine nucleotidebinding protein, beta 2250614959NM_130734w, xguanine nucleotide bindingEST, Weakly similar to B33928 GTP-protein (G protein), betabinding protein beta chain homologpolypeptide 2-like 1, guanine[H. sapiens], EST, Weakly similar tonucleotide binding protein,GBLP_HUMAN GUANINEbeta 2, related sequence 1NUCLEOTIDE-BINDING PROTEINBETA SUBUNIT-LIKE PROTEIN 12.3[H. sapiens], Homo sapiens cDNA:FLJ21913 fis, clone HEP03888, Musmusculus, Similar to hypothetical proteinFLJ10385, clone MGC: 28622IMAGE: 4220923, mRNA, complete cds,expressed sequence AL033335, guaninenucleotide binding protein (G protein),beta polypeptide 1-like, guaninenucleotide binding protein (G protein),beta polypeptide 2-like 1, guaninenucleotide binding protein, beta 2,125014960AI171319w, xguanine nucleotide bindingEST, Weakly similar to B33928 GTP-protein (G protein), betabinding protein beta chain homologpolypeptide 2-like 1, guanine[H. sapiens], EST, Weakly similar tonucleotide binding protein,GBLP_HUMAN GUANINEbeta 2, related sequence 1NUCLEOTIDE-BINDING PROTEINBETA SUBUNIT-LIKE PROTEIN 12.3[H. sapiens], Homo sapiens cDNA:FLJ21913 fis, clone HEP03888, Musmusculus, Similar to hypothetical proteinFLJ10385, clone MGC: 28622IMAGE: 4220923, mRNA, complete cds,SWI/SNF related, matrix associated,actin dependent regulator of chromatin,subfamily b, member 1, expressedsequence AL033335, guanine nucleotidebinding protein (G protein), betapolypeptide 1-like, guanine nucleotidebinding protein (G protein), betapolypeptide 2-like 1, guanine nucleotidebinding protein, beta 2, related sequence21751879NM_024138l, mguanine nucleotide bindingguanine nucleotide binding protein (Gprotein (G protein), gamma 7,protein), gamma 12, guanine nucleotideguanine nucleotide bindingbinding protein (G protein), gamma 7protein (G protein), gamma 7subunit175016025NM_012578p, qH1 histone family, member 0H1 histone family, member 0, H1 histonefamily, member O (oocyte-specific)175016026NM_012578p, q, s, t,H1 histone family, member 0H1 histone family, member 0, H1 histoneee, fffamily, member O (oocyte-specific)19641488NM_017182hH2A histone family, member YH2A histone family, member Y, RIKENcDNA 4933432H23 gene214717661NM_022674d, ggH2A histone family, member ZEST, Weakly similar to histone H2A.F/Zvariant [Homo sapiens] [H. sapiens],ESTs, Highly similar to S03644 histoneH2A.Z - rat [R. norvegicus], ESTs,Weakly similar to H2AZ_HUMANHISTONE H2A [H. sapiens], H2A histonefamily, member Z, Homo sapiens cDNAFLJ32241 fis, clone PLACE6005231,RIKEN cDNA C530002L11 gene, histoneH2A.F/Z variant18345033NM_012966s, theat shock 10 kDa protein 1ESTs, Weakly similar to S47532(chaperonin 10), heat shockchaperonin groES [H. sapiens],10 kD protein 1 (chaperoninexpressed sequence AW108200, heat10)shock 10 kDa protein 1 (chaperonin 10),heat shock 10 kD protein 1 (chaperonin10)18345034NM_012966ee, ffheat shock 10 kDa protein 1ESTs, Weakly similar to S47532(chaperonin 10), heat shockchaperonin groES [H. sapiens],10 kD protein 1 (chaperoninexpressed sequence AW108200, heat10)shock 10 kDa protein 1 (chaperonin 10),heat shock 10 kD protein 1 (chaperonin10)250511709NM_130431sheat shock 27 kD protein 2EST, Moderately similar to heat shock27 kD protein 2 [Rattus norvegicus][R. norvegicus], heat shock 27 kD protein 217071466M14050eheat shock 70 kD protein 5EST, Weakly similar to GR78_RAT 78 KD(glucose-regulated protein,GLUCOSE-REGULATED PROTEIN78 kD)PRECURSOR (GRP 78)(IMMUNOGLOBULIN HEAVY CHAINBINDING PROTEIN) (BIP)(STEROIDOGENESIS-ACTIVATORPOLYPEPTIDE) [R. norvegicus],expressed sequence AL022860, heatshock 70 kD protein 5 (glucose-regulatedprotein, 78 kD)218517764NM_024351e, p, r,heat shock 70 kD protein 8EST, Moderately similar toee, ffHS7C_HUMAN HEAT SHOCKCOGNATE 71 KDA PROTEI [H. sapiens],EST, Weakly similar to A27077 dnaK-type molecular chaperone [H. sapiens],EST, Weakly similar to A45935 dnaK-type molecular chaperone hsc70 -mouse [M. musculus], ESTs, Moderatelysimilar to HS7C MOUSE HEAT SHOCKCOGNATE 71 KDA PROTEIN[M. musculus], ESTs, Weakly similar toHS7C MOUSE HEAT SHOCKCOGNATE 71 KDA PROTEIN[M. musculus], heat shock 70 kD protein 8218517765NM_024351e, p, q, r,heat shock 70 kD protein 8EST, Moderately similar toee, ffHS7C_HUMAN HEAT SHOCKCOGNATE 71 KDA PROTEI [H. sapiens],EST, Weakly similar to A27077 dnaK-type molecular chaperone [H. sapiens],EST, Weakly similar to A45935 dnaK-type molecular chaperone hsc70 -mouse [M. musculus], ESTs, Moderatelysimilar to HS7C MOUSE HEAT SHOCKCOGNATE 71 KDA PROTEIN[M. musculus], ESTs, Weakly similar toHS7C MOUSE HEAT SHOCKCOGNATE 71 KDA PROTEIN[M. musculus], heat shock 70 kD protein 8140216081AI179610a, p, q, r,heme oxygenase (decycling) 1heme oxygenase (decycling) 1y, z, gg,kk175116080NM_012580p, q, y, z,heme oxygenase (decycling) 1heme oxygenase (decycling) 1kk138918907AI178971c, vhemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 114061686AI179971chemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 114061687AI179971b, c, vhemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 118691684NM_013096b, c, vhemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 118691685NM_013096b, c, vhemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 118691688NM_013096chemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 118691689NM_013096b, c, vhemoglobin alpha, adult chainEST, Moderately similar to HBA_RAT2, hemoglobin, alpha 1HEMOGLOBIN ALPHA-1 AND ALPHA-2CHAINS [R. norvegicus], EST, Weaklysimilar to HBA_RAT HEMOGLOBINALPHA-1 AND ALPHA-2 CHAINS[R. norvegicus], ESTs, Moderately similarto HBA_RAT HEMOGLOBIN ALPHA-1AND ALPHA-2 CHAINS [R. norvegicus],RIKEN cDNA 2510042H12 gene,hemoglobin alpha chain complex,hemoglobin alpha, adult chain 1,hemoglobin, alpha 1, hemoglobin, alpha2, hemoglobin, theta 130518897AA875207themoglobin beta chainEST, Moderately similar to HBB1_RATcomplex, hemoglobin, betaHemoglobin beta chain, major-form[R. norvegicus], expressed sequenceAI036344, hemoglobin, beta,hemoglobin, beta adult major chain,hemoglobin, beta adult minor chain,hemoglobin, delta83917830AI011943chemoglobin beta chainEST, Moderately similar to HBB1_RATcomplex, hemoglobin, betaHemoglobin beta chain, major-form[R. norvegicus], expressed sequenceAI036344, hemoglobin, beta,hemoglobin, beta adult major chain,hemoglobin, beta adult minor chain,hemoglobin, delta235625468NM_033234b, c, vhemoglobin beta chainEST, Moderately similar to HBB1_RATcomplex, hemoglobin, betaHemoglobin beta chain, major-form[R. norvegicus], expressed sequenceAI036344, hemoglobin, beta,hemoglobin, beta adult major chain,hemoglobin, beta adult minor chain,hemoglobin, delta235617829NM_033234chemoglobin beta chainEST, Moderately similar to HBB1_RATcomplex, hemoglobin, betaHemoglobin beta chain, major-form[R. norvegicus], expressed sequenceAI036344, hemoglobin, beta,hemoglobin, beta adult major chain,hemoglobin, beta adult minor chain,hemoglobin, delta235617832NM_033234b, c, vhemoglobin beta chainEST, Moderately similar to HBB1_RATcomplex, hemoglobin, betaHemoglobin beta chain, major-form[R. norvegicus], expressed sequenceAI036344, hemoglobin, beta,hemoglobin, beta adult major chain,hemoglobin, beta adult minor chain,hemoglobin, delta8756758AI013394d, jj, kkheparan sulfateEST, Highly similar to HSS2 MOUSE(glucosamine) 3-O-HEPARIN SULFATE N-sulfotransferase 1DEACETYLASE/N-SULFOTRANSFERASE [M. musculus],ESTs, Weakly similar to HSS2 MOUSEHEPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE [M. musculus],ESTs, Weakly similar to HSS2_HUMANHEPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE [H. sapiens], N-deacetylase/N-sulfotransferase (heparanglucosaminyl) 2, N-deacetylase/N-sulfotransferase (heparan glucosaminyl)3, N-deacetylase/N-sulfotransferase(heparin glucosaminyl) 4,N-deacetylase/N-sulfotransferase 4, RIKENcDNA 4930439H17 gene, heparansulfate (glucosamine) 3-O-sulfotransferase 3A, heparan sulfate(glucosamine) 3-O-sulfotransferase 4158718151AI237212f, g, hhhepatitis B virus x interactinghepatitis B virus x interacting proteinprotein22694235NM_031330b, d, f, g,heterogeneous nuclearDAZ associated protein 1, Musashil, mribonucleoprotein A/Bhomolog 1 (Drosophila), Musashihomolog 2 (Drosophila), RIKEN cDNA4933434H11 gene, expressed sequenceAA959857, heterogeneous nuclearribonucleoprotein A/B, musashi homolog1 (Drosophila)198117501NM_017248l, mheterogeneous nuclearESTs, Highly similar to I52962 FBRNPribonucleoprotein A1[H. sapiens], ESTs, Highly similar toheterogeneous ribonuclear particleprotein A1 [H. sapiens], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], ESTs, Weakly similar toROA1_RAT Heterogeneous nuclearribonucleoprotein A1 (Helix-destabilizingprotein) (Single-strand binding protein)(hnRNP core protein A1) (HDP)[R. norvegicus], Homo sapiens cDNA:FLJ22720 fis, clone HSI14320, Musmusculus, Similar to TAR DNA bindingprotein, clone MGC: 19284IMAGE: 4016437, mRNA, complete cds,RIKEN cDNA 4930547K05 gene,heterogeneous nuclear ribonucleoproteinA1198117502NM_017248l, mheterogeneous nuclearESTs, Highly similar to I52962 FBRNPribonucleoprotein A1[H. sapiens], ESTs, Highly similar toheterogeneous ribonuclear particleprotein A1 [H. sapiens], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], ESTs, Weakly similar toROA1_RAT Heterogeneous nuclearribonucleoprotein A1 (Helix-destabilizingprotein) (Single-strand binding protein)(hnRNP core protein A1) (HDP)[R. norvegicus], Homo sapiens cDNA:FLJ22720 fis, clone HSI14320, Musmusculus, Similar to TAR DNA bindingprotein, clone MGC: 19284IMAGE: 4016437, mRNA, complete cds,RIKEN cDNA 4930547K05 gene,heterogeneous nuclear ribonucleoproteinA124822413NM_057141b, g, n,heterogeneous nuclearESTs, Highly similar to heterogeneouso, u, vribonucleoprotein Knuclear ribonucleoprotein K, isoform b;dC-stretch binding protein;transformation upregulated nuclearprotein [Homo sapiens] [H. sapiens],ESTs, Weakly similar to heterogeneousnuclear ribonucleoprotein K [Rattusnorvegicus] [R. norvegicus],heterogeneous nuclear ribonucleoproteinK, poly(rC) binding protein 3, poly(rC)binding protein 424822416NM_057141theterogeneous nuclearESTs, Highly similar to heterogeneousribonucleoprotein Knuclear ribonucleoprotein K, isoform b;dC-stretch binding protein;transformation upregulated nuclearprotein [Homo sapiens] [H. sapiens],ESTs, Weakly similar to heterogeneousnuclear ribonucleoprotein K [Rattusnorvegicus] [R. norvegicus],heterogeneous nuclear ribonucleoproteinK, poly(rC) binding protein 3, poly(rC)binding protein 476110108AI007857u, vHGF-regulated tyrosineESTs, Weakly similar to HGF-regulatedkinase substrate, hepatocytetyrosine kinase substrate [Musgrowth factor-regulatedmusculus] [M. musculus], HGF-regulatedtyrosine kinase substratetyrosine kinase substrate, RIKEN cDNA1700013B03 gene, WD40- and FYVE-domain containing protein 2, hepatocytegrowth factor-regulated tyrosine kinasesubstrate, myotubularin related protein 3,phosphoinositide-binding protein SR1,target of myb1 homolog (chicken), zincfinger protein, subfamily 2A (FYVEdomain containing), 119421375NM_017122n, ohippocalcinESTs, Highly similar to HIPP_HUMANNeuron specific calcium-binding proteinhippocalcin (P23K) (Calcium-bindingprotein BDR-2) [R. norvegicus], ESTs,Weakly similar to HIPP RAT NEURONSPECIFIC CALCIUM-BINDINGPROTEIN HIPPOCALCIN [M. musculus],hippocalcin36917345AA892014hhHLA-B associated transcriptESTs, Highly similar to S336811, HLA-B-associatedtranslation initiation factor elF-4A.Itranscript 1A[H. sapiens], ESTs, Weakly similar toA42811 nuclear RNA helicase (DEADfamily) homolog - rat [R. norvegicus],RIKEN cDNA 2610307C23 gene,hypothetical protein MGC66641839571NM_012982cc, ddhomeo box, msh-like 2, mshhomeo box, msh-like 2, msh homeo boxhomeo box homolog 2homolog 2 (Drosophila)(Drosophila)236815748NM_053309iiHomer, neuronal immediateHomer, neuronal immediate early gene,early gene, 2, homer,2, homer, neuronal immediate earlyneuronal immediate earlygene, 1gene, 2188822306NM_013179aa, bbhypocretin, hypocretinhypocretin, hypocretin (orexin)(orexin) neuropeptideneuropeptide precursorprecursor21881146NM_024359y, zhypoxia inducible factor 1,Mus musculus inhibitory PAS domainalpha subunit, hypoxia-protein (Ipas) mRNA, complete cds,inducible factor 1, alphahypoxia inducible factor 1, alpha subunit,subunit (basic helix-loop-helixhypoxia-inducible factor 1, alpha subunittranscription factor)(basic helix-loop-helix transcriptionfactor), neuronal PAS domain protein 1,single-minded 1, single-minded 2, single-minded homolog 1 (Drosophila)230221772NM_031624y, zimmunoglobulin (CD79A)expressed sequence C81413,binding protein 1immunoglobulin (CD79A) binding protein1, immunoglobulin (CD79A) bindingprotein 1b19271427NM_017063hhimportin beta, karyopherinimportin beta, karyopherin (importin)(importin) beta 1beta 1, karyopherin (importin) beta 3180010248NM_012797b, j, k, s,inhibitor of DNA binding 1,t, u, jj, kkinhibitor of DNA binding 1,dominant negative helix-loop-helix protein185715253NM_013058n, o, s, tinhibitor of DNA binding 3,inhibitor of DNA binding 3,dominant negative helix-loop-helix protein222318188NM_031046gginositol 1,4,5-triphosphateESTs, Highly similar to IP3R MOUSEreceptor 2, inositol 1,4,5-INOSITOL 1,4,5-TRISPHOSPHATE-triphosphate receptor, type 2BINDING PROTEIN TYPE 1RECEPTOR [M. musculus], ESTs,Moderately similar to IP3R MOUSEINOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1RECEPTOR [M. musculus], ESTs,Weakly similar to IP3R MOUSEINOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1RECEPTOR [M. musculus], inositol 1,4,5-triphosphate receptor 1, inositol 1,4,5-triphosphate receptor 2, inositol 1,4,5-triphosphate receptor 5, inositol 1,4,5-triphosphate receptor, type 2, ryanodinereceptor 2 (cardiac), ryanodine receptor2, cardiac, ryanodine receptor 326023336AA859981ee, ff, jj,inositol(myo)-1 (or 4)-ESTs, Moderately similar to A Chain A,kkmonophosphatase 2Inositol Monophosphatase [H. sapiens],RIKEN cDNA 2900059K10 gene,inositol(myo)-1 (or 4)-monophosphatase1, inositol(myo)-1 (or 4)-monophosphatase 2236325072NM_052807j, kinsulin-like growth factor 1EST, Highly similar to IG1R_MOUSEreceptor, insulin-like growthINSULIN-LIKE GROWTH FACTOR Ifactor I receptorRECEPTOR PRECURSOR[M. musculus], EST, Moderately similar toIG1R_MOUSE INSULIN-LIKE GROWTHFACTOR I RECEPTOR PRECURSOR[M. musculus], ESTs, Highly similar toIG1R_MOUSE INSULIN-LIKE GROWTHFACTOR I RECEPTOR PRECURSOR[M. musculus], insulin receptor-relatedreceptor, insulin-like growth factor 1receptor, insulin-like growth factor Ireceptor175415098NM_012588bbinsulin-like growth factorinsulin-like growth factor binding protein 3binding protein 3135614989AI177366f, g, l, m,integrin beta 1 (fibronectinintegrin beta 1 (fibronectin receptorkkreceptor beta), integrin, betabeta), integrin beta 2, integrin beta 7,1 (fibronectin receptor, betaintegrin, beta 1 (fibronectin receptor,polypeptide, antigen CD29beta polypeptide, antigen CD29 includesincludes MDF2, MSK12)MDF2, MSK12), integrin, beta 2 (antigenCD18 (p95), lymphocyte function-associated antigen 1; macrophageantigen 1 (mac-1) beta subunit), integrin,beta 718352555NM_012967a, y, z,intercellular adhesionESTs, Weakly similar to ICA1_HUMANkkmolecule, intercellularINTERCELLULAR ADHESIONadhesion molecule 1 (CD54),MOLECULE-1 PRECURSORhuman rhinovirus receptor[H. sapiens], intercellular adhesionmolecule, intercellular adhesionmolecule 1 (CD54), human rhinovirusreceptor, intercellular adhesion molecule3, intercellular adhesion molecule 5,telencephalin201720318NM_019127n, ointerferon beta, fibroblast,interferon beta, fibroblast, interferon,interferon, beta 1, fibroblastbeta 1, fibroblast204417908NM_019242a, p, q, y,interferon-relatedESTs, Weakly similar to IFR1_RATz, bb, ee,developmental regulator 1INTERFERON-RELATEDffDEVELOPMENTAL REGULATOR 1(NERVE GROWTH FACTOR-INDUCIBLE PROTEIN PC4) (IRPR)[R. norvegicus], interferon-relateddevelopmental regulator 1, interferon-related developmental regulator 22516657NM_133380j, k, y, zinterleukin 4 receptor,colony stimulating factor 2 receptor, betainterleukin 4 receptor, alpha1, low-affinity (granulocyte-macrophage),interleukin 4 receptor, interleukin 4receptor, alpha19146598NM_017020j, kinterleukin 6 receptor,interleukin 6 receptorinterleukin 6 receptor, alpha175524716NM_012589j, k, p, qinterleukin 6, interleukin 6(interferon, beta 2)2158202NM_022863h, liron responsive elementbinding protein 2, iron-responsive element bindingprotein 2227517427NM_031510b, u, visocitrate dehydrogenase 1ESTs, Highly similar to IDHC_RAT(NADP+), solubleISOCITRATE DEHYDROGENASE[NADP] CYTOPLASMIC(OXALOSUCCINATEDECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [R. norvegicus],expressed sequence AI788952,isocitrate dehydrogenase 1 (NADP+),soluble, isocitrate dehydrogenase 2(NADP+), mitochondrial17564450NM_012592cisovaleryl Coenzyme AESTs, Moderately similar todehydrogenase, isovalerylIVD_HUMAN ISOVALERYL-COAcoenzyme A dehydrogenaseDEHYDROGENASE, MITOCHONDRIALPRECURSOR [H. sapiens], isovalerylCoenzyme A dehydrogenase, isovalerylcoenzyme A dehydrogenase227612580NM_031514a, h, l, j,Janus kinase 2, Janus kinaseESTs, Weakly similar to JC4127 protein-k, y, z2 (a protein tyrosine kinase)tyrosine kinase (EC 2.7.1.112) - rat[R. norvegicus], Janus kinase 1, Januskinase 1 (a protein tyrosine kinase),Janus kinase 2, Janus kinase 2 (aprotein tyrosine kinase), expressedsequence AI504024, expressedsequence C81284, tyrosine kinase 2227612581NM_031514y, z, hhJanus kinase 2, Janus kinaseESTs, Weakly similar to JC4127 protein-2 (a protein tyrosine kinasetyrosine kinase (EC 2.7.1.112) - rat[R. norvegicus], Janus kinase 1, Januskinase 1 (a protein tyrosine kinase),Janus kinase 2, Janus kinase 2 (aprotein tyrosine kinase), expressedsequence AI504024, expressedsequence C81284, tyrosine kinase 220382632NM_019213cc, ddjumping translocationESTs, Highly similar to jumpingbreakpointtranslocation breakpoint [Rattusnorvegicus] [R. norvegicus], ESTs,Moderately similar to jumpingtranslocation breakpoint [Rattusnorvegicus] [R. norvegicus], jumpingtranslocation breakpoint208922351NM_021835ee, ffJun oncogene, v-jun sarcomaJun oncogene, v-jun sarcoma virus 17virus 17 oncogene homologoncogene homolog (avian)(avian)233015864NM_031797rkangai 1 (suppression ofkangai 1 (suppression of tumorigenicitytumorigenicity 6, prostate),6, prostate), kangai 1 (suppression ofkangai 1 (suppression oftumorigenicity 6, prostate; CD82 antigentumorigenicity 6, prostate;(R2 leukocyte antigen, antigen detectedCD82 antigen (R2 leukocyteby monoclonal and antibody IA4)),antigen, antigen detected bytetraspan 1monoclonal and antibodyIA4))239014380NM_053536e, y, zKruppel-like factor 1524898641NM_057211bbKruppel-like factor 9, basicESTs, Moderately similar to Kruppel-liketranscription element bindingfactor 9 [Rattus norvegicus]protein 1[R. norvegicus], Kruppel-like factor 9,basic transcription element bindingprotein 1, expressed sequenceAL022736191517807NM_017025h, llactate dehydrogenase 1, Alactate dehydrogenase 1, A chain,chain, lactate dehydrogenase Alactate dehydrogenase A, lactatedehydrogenase A-like, lactatedehydrogenase C17577125NM_012595aa, bblactate dehydrogenase 2, Blactate dehydrogenase 2, B chain,chain, lactate dehydrogenase Blactate dehydrogenase B87320086AI013260zlamin A, lamin A/C194924885NM_017138h, l, w, xlaminin receptor 1 (67 kD,EST, Weakly similar to 1405340A proteinribosomal protein SA)40 kD [M. musculus], EST, Weakly similarto RSP4 MOUSE 40S RIBOSOMALPROTEIN SA [M. musculus], ESTs,Highly similar to A31233 ribosomalprotein RS.40K, cytosolic [H. sapiens],ESTs, Moderately similar to laminin-binding protein [H. sapiens], expressedsequence AL022858, laminin receptor 1(67 kD, ribosomal protein SA)194924886NM_017138h, l, w, xlaminin receptor 1 (67 kD,EST, Weakly similar to 1405340A proteinribosomal protein SA)40 kD [M. musculus], EST, Weakly similarto RSP4 MOUSE 40S RIBOSOMALPROTEIN SA [M. musculus], ESTs,Highly similar to A31233 ribosomalprotein RS.40K, cytosolic [H. sapiens],ESTs, Moderately similar to laminin-binding protein [H. sapiens], expressedsequence AL022858, laminin receptor 1(67 kD, ribosomal protein SA)183622434NM_012974l, mlaminin, beta 2, laminin, betaESTs, Weakly similar to LMB2_HUMAN2 (laminin S)LAMININ BETA-2 CHAIN PRECURSOR[H. sapiens], Rattus norvegicus laminin-5alpha 3 chain mRNA, complete cds,expressed sequence AW211941,expressed sequence C80098,hypothetical protein BC018697, lamininB1 subunit 1, laminin, beta 1, laminin,beta 2, laminin, beta 2 (laminin S),laminin, beta 4183622435NM_012974claminin, beta 2, laminin, betaESTs, Weakly similar to LMB2_HUMAN2 (laminin S)LAMININ BETA-2 CHAIN PRECURSOR[H. sapiens], Rattus norvegicus laminin-5alpha 3 chain mRNA, complete cds,expressed sequence AW211941,expressed sequence C80098,hypothetical protein BC018697, lamininB1 subunit 1, laminin, beta 1, laminin,beta 2, laminin, beta 2 (laminin S),laminin, beta 4233522321NM_031832a, h, l, n,lectin, galactose binding,EST, Weakly similar to A35820 galectino, x, kksoluble 3, lectin, galactoside-3 [H. sapiens], galectin-related inter-fiberbinding, soluble, 3 (galectin 3)protein, lectin, galactoside-binding,soluble, 3 (galectin 3)60222283AA945172eleucine aminopeptidase 3aminopeptidase-like 1, leucineaminopeptidase 323697207NM_053326hhLIM protein (similar to ratLIM and senescent cell antigen-likeprotein kinase C-bindingdomains 1, LIM and senescent cellenigma), enigma homolog (R.antigen-like domains 1-like, LIM proteinnorvegicus)(similar to rat protein kinase C-bindingenigma), RIKEN cDNA 1110003B01gene, enigma (LIM domain protein),enigma homolog (R. norvegicus),leupaxin178125563NM_012732f, glipase A, lysosomal acid,ESTs, Weakly similar to cholesterolcholesterol esterase (Wolmanesterase (pancreatic), see D3Wox12,disease), lysosomal acidD3Wox13, D3Wox26 and D3Mgh25lipase 1[Rattus norvegicus] [R. norvegicus],lipase A, lysosomal acid, cholesterolesterase (Wolman disease), lysosomalacid lipase 1178116613NM_012732glipase A, lysosomal acid,ESTs, Weakly similar to cholesterolcholesterol esterase (Wolmanesterase (pancreatic), see D3Wox12,disease), lysosomal acidD3Wox13, D3Wox26 and D3Mgh25lipase 1[Rattus norvegicus] [R. norvegicus],lipase A, lysosomal acid, cholesterolesterase (Wolman disease), lysosomalacid lipase 1175818387NM_012598w, xlipoprotein lipaseESTs, Highly similar to JH0790lipoprotein lipase (EC 3.1.1.34)precursor - rat [R. norvegicus], lipase,endothelial, lipoprotein lipase175818386NM_012598w, xlipoprotein lipaseESTs, Highly similar to JH0790lipoprotein lipase (EC 3.1.1.34)precursor - rat [R. norvegicus],Lipoprotein lipase, lipase, endothelial,lipoprotein lipase23759352NM_053347u, vLIS1-interacting proteinNUDE1, rat homolog, nucleardistribution gene E homolog(Aspergillus)21721713AA851637e, rLutheran blood groupLutheran blood group (Auberger b(Auberger b antigen included)antigen included)180818770NM_012857hhlysosomal membraneCD68 antigen, ESTs, Weakly similar toglycoprotein 1, lysosomal-LMP1_RAT LYSOSOME-ASSOCIATEDassociated membrane protein 1MEMBRANE GLYCOPROTEIN 1PRECURSOR (LAMP-1) (120 KDLYSOSOMAL MEMBRANEGLYCOPROTEIN) (LGP-120) (CD107A)[R. norvegicus], chromosome 20 openreading frame 103, lysosomal membraneglycoprotein 1, lysosomal-associatedmembrane protein 1, lysosomal-associated membrane protein 319286653NM_017068dlysosomal membraneCD68 antigen, ESTs, Weakly similar toglycoprotein 2, lysosomal-JC4317 lysosome-associated membraneassociated membrane protein 2protein 2 precursor, splice form B[H. sapiens], lysosomal membraneglycoprotein 2, lysosomal-associatedmembrane protein 219286654NM_017068b, vlysosomal membraneCD68 antigen, ESTs, Weakly similar toglycoprotein 2, lysosomal-JC4317 lysosome-associated membraneassociated membrane protein 2protein 2 precursor, splice form B[H. sapiens], lysosomal membraneglycoprotein 2, lysosomal-associatedmembrane protein 241012118AA892775a, n, xlysozyme, lysozyme (renalEST, Weakly similar to LYC1_RATamyloidosis)Lysozyme C, type 1 precursor (1,4-beta-N-acetylmuramidase C) [R. norvegicus],RIKEN cDNA 9530003J23 gene,lysozyme, lysozyme (renal amyloidosis),similar to lysozyme C-1 (1,4-beta-N-acylmuramidase C, EC 3.2.1.17)19261942NM_017061f, lllysyl oxidaseESTs, Moderately similar toLYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE PRECURSOR [H. sapiens],ESTs, Moderately similar to LYOX_RATProtein-lysine 6-oxidase precursor (Lysyloxidase) [R. norvegicus], ESTs, Weaklysimilar to LYOX_RAT Protein-lysine 6-oxidase precursor (Lysyl oxidase)[R. norvegicus], lysyl oxidase, lysyloxidase-like, lysyl oxidase-like 1, lysyloxidase-like 219261943NM_017061s, tlysyl oxidaseESTs, Moderately similar toLYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE PRECURSOR [H. sapiens],ESTs, Moderately similar to LYOX_RATProtein-lysine 6-oxidase precursor (Lysyloxidase) [R. norvegicus], ESTs, Weaklysimilar to LYOX_RAT Protein-lysine 6-oxidase precursor (Lysyl oxidase)[R. norvegicus], lysyl oxidase, lysyloxidase-like, lysyl oxidase-like 1, lysyloxidase-like 2203315244NM_019191llMAD homolog 2 (Drosophila),MAD homolog 2 (Drosophila), MAD,MAD, mothers againstmothers against decapentaplegicdecapentaplegic homolog 2homolog 2 (Drosophila)(Drosophila)180913151NM_012862n, o, llmatrix Gla protein, matrixEST, Weakly similar to MGP_HUMANgamma-carboxyglutamateMATRIX GLA-PROTEIN PRECURSOR(gla) protein[H. sapiens], ESTs, Highly similar toMGP_HUMAN MATRIX GLA-PROTEINPRECURSOR [H. sapiens], matrix Glaprotein, matrix gamma-carboxyglutamate(gla) protein261516675U17565r, iiMCM6 minichromosomeEST, Weakly similar to MCM5_HUMANmaintenance deficient 6DNA REPLICATION LICENSING(MIS5 homolog, S. pombe)FACTOR MCM5 [H. sapiens], ESTs,(S. cerevisiae), miniWeakly similar to MCM6_HUMAN DNAchromosome maintenanceREPLICATION LICENSING FACTORdeficient 6 (S. cerevisiae)MCM6 [H. sapiens], MCM2minichromosome maintenance deficient2, mitotin (S. cerevisiae), MCM6minichromosome maintenance deficient6 (MIS5 homolog, S. pombe) (S.cerevisiae), mini chromosomemaintenance deficient 2 (S. cerevisiae),mini chromosome maintenance deficient5 (S. cerevisiae), mini chromosomemaintenance deficient 6 (S. cerevisiae),mini chromosome maintenance deficient7 (S. cerevisiae)267525737X70667l, mmelanocortin 3 receptor34419321AA891666cc, ddmelanoma antigen, family D, 1RIKEN cDNA 1700056A17 gene, RIKENcDNA 1700080O16 gene, RIKEN cDNA2410003J06 gene, RIKEN cDNA3830417A13 gene, melanoma antigen,family D, 1, melanoma antigen, family L, 224942541NM_080479aa, bbmelanoma antigen, family D, 2RIKEN cDNA 2010107K23 gene, RIKENcDNA 5730494G16 gene, generaltranscription factor ll H, polypeptide 1(62 kD subunit), melanoma antigen,family B, 3, melanoma antigen, family D,2, melanoma antigen, family E, 118775837NM_013143cc, ddmeprin 1 alpha, meprin A,expressed sequence AI098089, meprinalpha (PABA peptide1 alpha, meprin A, alpha (PABA peptidehydrolase)hydrolase)195417287NM_017149iimesenchyme homeo box 2homeo box A11, mesenchyme homeo(growth arrest-specific homeobox 1, mesenchyme homeo box 2box), mesenchyme(growth arrest-specific homeo box),homeobox 2mesenchyme homeobox 1, mesenchymehomeobox 2255015189NM_138826j, k, y, z,metallothionein 1,EST, Moderately similar to Cd-7ee, ff, kkmetallothionein 1AMetallothionein-2 [H. sapiens], EST,(functional)Moderately similar to SMHU1Emetallothionein 1E [H. sapiens], ESTs,Moderately similar to MT1_RATMETALLOTHIONEIN-I (MT-I)[R. norvegicus], metallothionein 1,metallothionein 4, metallothionein IV255015190NM_138826j, k, y, z,metallothionein 1,EST, Moderately similar to Cd-7iimetallothionein 1AMetallothionein-2 [H. sapiens], EST,(functional)Moderately similar to SMHU1Emetallothionein 1E [H. sapiens], ESTs,Moderately similar to MT1_RATMETALLOTHIONEIN-I (MT-I)[R. norvegicus], metallothionein 1,metallothionein 4, metallothionein IV214220762NM_022588r, s, tmetastasis associated 1ESTs, Highly similar to metastasisassociated 1 [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar tometastasis associated 1 [Rattusnorvegicus] [R. norvegicus], KIAA1266protein, KIAA1610 protein, metastasisassociated 1, metastasis associated 1-like 1, metastasis associated 3,metastasis-associated 1-like 1197013938NM_017212jj, kkmicrotubule-associatedprotein tau197013940NM_017212amicrotubule-associatedprotein tau251017564NM_133283hhmitogen activated proteinkinase kinase 2, mitogen-activated protein kinasekinase 2230014957NM_031622fmitogen-activated proteinESTs, Weakly similar to B40033 proteinkinase 6kinase (EC 2.7.1.37) ERK3 - rat[R. norvegicus], mitogen-activated proteinkinase 4, mitogen-activated proteinkinase 653616499AA925300p, ee, ff,mitogen-activated proteinESTs, Highly similar to M3K3 MOUSEggkinase kinase kinase 3MITOGEN-ACTIVATED PROTEINKINASE KINASE KINASE 3[M. musculus], ESTs, Moderately similarto S12207 hypothetical protein[M. musculus], ESTs, Weakly similar toM3K3_HUMAN MITOGEN-ACTIVATEDPROTEIN KINASE KINASE KINASE 3[H. sapiens], hypothetical proteinFLJ23074, mitogen activated proteinkinase kinase kinase 1, mitogenactivated protein kinase kinase kinase 2,mitogen activated protein kinase kinasekinase 3, mitogen-activated proteinkinase kinase kinase 2, mitogen-activated protein kinase kinase kinase 3215658NM_022715u, vMitral valve prolapse, familial,major vault protein203621508NM_019208iimultiple endocrine neoplasiamultiple endocrine neoplasia 1, multiple1, multiple endocrineendocrine neoplasia Ineoplasia I115215291AI111401hhmultiple inositolpolyphosphate histidinephosphatase 1, multipleinositol polyphosphatehistidine phosphatase, 1203421421NM_019196llmultiple PDZ domain proteinESTs, Highly similar to multiple PDZdomain protein [Mus musculus][M. musculus], ESTs, Weakly similar toT30259 multiple PDZ domain protein -mouse [M. musculus], ESTs, Weaklysimilar to T46612 multi PDZ domainprotein 1 - rat [R. norvegicus], Homosapiens cDNA FLJ25282 fis, cloneSTM06685, highly similar to Rattusnorvegicus mRNA for multi PDZ domainprotein, RIKEN cDNA 2810455B10gene, channel-interacting PDZ domainprotein, multiple PDZ domain protein230617448NM_031668h, lMYB binding protein (P160)1a17592628NM_012603a, p, q, y, zmyelocytomatosis oncogene,myelocytomatosis oncogene, v-mycv-myc myelocytomatosis viralmyelocytomatosis viral oncogeneoncogene homolog (avian)homolog (avian)17592629NM_012603a, j, k, p,myelocytomatosis oncogene,myelocytomatosis oncogene, v-mycq, y, z,v-myc myelocytomatosis viralmyelocytomatosis viral oncogeneee, ff, kkoncogene homolog (avian)homolog (avian)19781498NM_017239dmyosin heavy chain, cardiacEST, Weakly similar to MYH6_RATmuscle, adult, myosin, heavyMyosin heavy chain, cardiac musclepolypeptide 6, cardiacalpha isoform (MyHC-alpha)muscle, alpha[R. norvegicus], ESTs, Moderately similar(cardiomyopathy,to MYOSIN HEAVY CHAIN, CARDIAChypertrophic 1)MUSCLE ALPHA ISOFORM[M. musculus], ESTs, Weakly similar toMYSA_HUMAN MYOSIN HEAVYCHAIN, CARDIAC MUSCLE ALPHAISOFORM [H. sapiens], KIAA1000protein, myosin heavy chain, cardiacmuscle, adult, myosin, heavypolypeptide 2, skeletal muscle, adult,myosin, heavy polypeptide 4, skeletalmuscle, myosin, heavy polypeptide 7,cardiac muscle, beta197920482NM_017240c, gmyosin heavy chain, cardiacEST, Highly similar to MYH7_RATmuscle, adult, myosin, heavyMyosin heavy chain, cardiac musclepolypeptide 6, cardiacbeta isoform (MyHC-beta)muscle, alpha[R. norvegicus], ESTs, Moderately similar(cardiomyopathy,to MYOSIN HEAVY CHAIN, CARDIAChypertrophic 1), myosin,MUSCLE ALPHA ISOFORMheavy polypeptide 7, cardiac[M. musculus], ESTs, Weakly similar tomuscle, betaMYHB_MOUSE MYOSIN HEAVYCHAIN, SMOOTH MUSCLE ISOFORM(SMMHC) [M. musculus], ESTs, Weaklysimilar to PCNT MOUSE PERICENTRIN[M. musculus], RIKEN cDNA 4932408L24gene, myosin heavy chain, cardiacmuscle, adult, myosin heavy chain-like,myosin, heavy polypeptide 2, skeletalmuscle, adult, myosin, heavypolypeptide 4, skeletal muscle, myosin,heavy polypeptide 7, cardiac muscle,beta197920483NM_017240dmyosin heavy chain, cardiacEST, Highly similar to MYH7_RATmuscle, adult, myosin, heavyMyosin heavy chain, cardiac musclepolypeptide 6, cardiacbeta isoform (MyHC-beta)muscle, alpha[R. norvegicus], ESTs, Moderately similar(cardiomyopathy,to MYOSIN HEAVY CHAIN, CARDIAChypertrophic 1), myosin,MUSCLE ALPHA ISOFORMheavy polypeptide 7, cardiac[M. musculus], ESTs, Weakly similar tomuscle, betaMYHB_MOUSE MYOSIN HEAVYCHAIN, SMOOTH MUSCLE ISOFORM(SMMHC) [M. musculus], ESTs, Weaklysimilar to PCNT MOUSE PERICENTRIN[M. musculus], RIKEN cDNA 4932408L24gene, myosin heavy chain, cardiacmuscle, adult, myosin heavy chain-like,myosin, heavy polypeptide 2, skeletalmuscle, adult, myosin, heavypolypeptide 4, skeletal muscle, myosin,heavy polypeptide 7, cardiac muscle,beta197920484NM_017240emyosin heavy chain, cardiacEST, Highly similar to MYH7_RATmuscle, adult, myosin, heavyMyosin heavy chain, cardiac musclepolypeptide 6, cardiacbeta isoform (MyHC-beta)muscle, alpha[R. norvegicus], ESTs, Moderately similar(cardiomyopathy,to MYOSIN HEAVY CHAIN, CARDIAChypertrophic 1), myosin,MUSCLE ALPHA ISOFORMheavy polypeptide 7, cardiac[M. musculus], ESTs, Weakly similar tomuscle, betaMYHB_MOUSE MYOSIN HEAVYCHAIN, SMOOTH MUSCLE ISOFORM(SMMHC) [M. musculus], ESTs, Weaklysimilar to PCNT MOUSE PERICENTRIN[M. musculus], RIKEN cDNA 4932408L24gene, myosin heavy chain, cardiacmuscle, adult, myosin heavy chain-like,myosin, heavy polypeptide 2, skeletalmuscle, adult, myosin, heavypolypeptide 4, skeletal muscle, myosin,heavy polypeptide 7, cardiac muscle,beta19781497NM_017239dmyosin heavy chain, cardiacEST, Weakly similar to MYH6_RATmuscle, adult, myosin, heavyMyosin heavy chain, cardiac musclepolypeptide 6, cardiacalpha isoform (MyHC-alpha)muscle, alpha[R. norvegicus], ESTs, Moderately similar(cardiomyopathy,to MYOSIN HEAVY CHAIN, CARDIAChypertrophic 1), myosin,MUSCLE ALPHA ISOFORMheavy polypeptide 7, cardiac[M. musculus], ESTs, Weakly similar tomuscle, betaMYSA_HUMAN MYOSIN HEAVYCHAIN, CARDIAC MUSCLE ALPHAISOFORM [H. sapiens], KIAA1000protein, myosin heavy chain, cardiacmuscle, adult, myosin, heavypolypeptide 2, skeletal muscle, adult,myosin, heavy polypeptide 4, skeletalmuscle, myosin, heavy polypeptide 7,cardiac muscle, beta246317653NM_053986cc, ddmyosin IBEST, Highly similar to MY1A_RATMyosin IA (Myosin I alpha) (MMI-alpha)(MMIa) (Myosin heavy chain myr 1)[R. norvegicus], EST, Weakly similar toMYOSIN I ALPHA [M. musculus], Musmusculus adult male small intestinecDNA, RIKEN full-length enriched library,clone:2010010B23:myosin, heavypolypeptide-like (110 kD), full insertsequence, myosin IB47024329AA899253aa, bbmyristoylated alanine richMus musculus 8 days embryo wholeprotein kinase C substrate,body cDNA, RIKEN full-length enrichedmyristoylated alanine-richlibrary, clone:5730519L10:myristoylatedprotein kinase C substratealanine rich protein kinase C substrate,full insert sequence, myristoylatedalanine rich protein kinase C substrate,myristoylated alanine-rich protein kinaseC substrate204120938NM_019223hhNADH dehydrogenaseESTs, Highly similar to NUMM MOUSE(ubiquinone) Fe-S protein 6NADH-UBIQUINONE(13 kD) (NADH-coenzyme QOXIDOREDUCTASE 13 KD-A SUBUNITreductase), NADH[M. musculus], NADH dehydrogenasedehydrogenase Fe-S protein 6(ubiquinone) Fe-S protein 6 (13 kD)(NADH-coenzyme Q reductase)228218389NM_031545a, d, y,natriuretic peptide precursorEST, Moderately similar to ANFBee, ffB, natriuretic peptideMOUSE BRAIN NATRIURETICprecursor type BPEPTIDE PRECURSOR [M. musculus],natriuretic peptide precursor B,natriuretic peptide precursor type B1762638NM_012613aa, bbnatriuretic peptide receptor 1,ESTs, Weakly similar to ATRIALnatriuretic peptide receptorNATRIURETIC PEPTIDE RECEPTOR AA/guanylate cyclase APRECURSOR [M. musculus], Mus(atrionatriuretic peptidemusculus, Similar to natriuretic peptidereceptor A)receptor 2, clone IMAGE: 5052434,mRNA, partial cds, natriuretic peptidereceptor 1, natriuretic peptide receptorA/guanylate cyclase A (atrionatriureticpeptide receptor A)17611298NM_012610dnerve growth factor receptor,Mus musculus, clone IMAGE: 5097359,nerve growth factor receptormRNA, partial cds, nerve growth factor(TNFR superfamily, memberreceptor, nerve growth factor receptor16)(TNFR superfamily, member 16), p75-like apoptosis-inducing death domainprotein PLAIDD17611299NM_012610cc, ddnerve growth factor receptor,Mus musculus, clone IMAGE: 5097359,nerve growth factor receptormRNA, partial cds, nerve growth factor(TNFR superfamily, memberreceptor, nerve growth factor receptor16)(TNFR superfamily, member 16), p75-like apoptosis-inducing death domainprotein PLAIDD194524522NM_017130u, vneuraminidase 2, sialidase 2neuraminidase 2, sialidase 2 (cytosolic(cytosolic sialidase)sialidase)24411780NM_053846u, vneurexin 2, neurexin IIESTs, Highly similar to C40228 neurexinII-alpha precursor - rat [R. norvegicus],ESTs, Moderately similar toNX1A_MOUSE_2 [Segment 2 of 2]Neurexin 1-alpha (Neurexin I-alpha)(Fragments) [M. musculus], ESTs,Weakly similar to NX1A_MOUSE_1[Segment 1 of 2] Neurexin 1-alpha(Neurexin I-alpha) (Fragments)[M. musculus], RIKEN cDNA4933401A11 gene, chondroitin sulfateproteoglycan 4229819022NM_031609s, t, jj, kkneuroblastoma, suppressiondante, neuroblastoma, suppression ofof tumorigenicity 1tumorigenicity 1209820450NM_022239b, l, m, u, vneuromedin, neuromedin Uneuromedin, neuromedin U176324506NM_012614cneuropeptide YRIKEN cDNA 0710005A05 gene,neuropeptide Y204724849NM_019248aa, bbneurotrophic tyrosine kinase,neurotrophic tyrosine kinase, receptor,receptor, type 3type 326291715U72660a, jj, kkninjurin 1ninjurin 1, ninjurin 2164920127AJ011116j, k, n, onitric oxide synthase 3ESTs, Moderately similar to A Chain A,(endothelial cell), nitric oxideHuman Endothelial Nitric Oxidesynthase 3, endothelial cellSynthase With Arginine Substrate {SUB66-492 [H. sapiens], Homo sapiens cDNAFLJ14885 fis, clone PLACE1003711,nitric oxide synthase 3 (endothelial cell),nitric oxide synthase 3, endothelial cell1840764NM_012988ee, ffnuclear factor I/Anuclear factor I/A, nuclear factor I/B,nuclear factor I/C, nuclear factor I/X,nuclear factor I/X (CCAAT-bindingtranscription factor)74317963AB012231jj, kknuclear factor I/BNuclear Factor IA, nuclear factor I/A,nuclear factor I/B, nuclear factor I/C,nuclear factor I/X, nuclear factor I/X(CCAAT-binding transcription factor)133124763AI176488jj, kknuclear factor I/BNuclear Factor IA, nuclear factor I/A,nuclear factor I/B, nuclear factor I/C,nuclear factor I/X, nuclear factor I/X(CCAAT-binding transcription factor)267025090X63594j, knuclear factor of kappa lightchain gene enhancer in B-cells inhibitor, alpha, nuclearfactor of kappa lightpolypeptide gene enhancer inB-cells inhibitor, alpha205824674NM_019328j, knuclear receptor subfamily 4,nuclear receptor subfamily 4, group A,group A, member 2member 22303567NM_031628p, qnuclear receptor subfamily 4,nuclear receptor subfamily 4, group A,group A, member 3member 375518731AF093139dnuclear RNA export factor 1,nuclear RNA export factor 1homolog (S. cerevisiae)2994339AA875121jj, kknuclear transcription factor Y,gamma, nuclear transcriptionfactor-Y gamma18104338NM_012866u, vnuclear transcription factor Y,gamma, nuclear transcriptionfactor-Y gamma184117394NM_012992hh, kknucleophosmin (nucleolarESTs, Highly similar to A32915phosphoprotein B23,nucleophosmin [H. sapiens],numatrin), nucleophosmin 1nucleophosmin 175216006AF062594ggnucleosome assembly proteinESTs, Highly similar to 2008109A set1-like 1gene [Rattus norvegicus] [R. norvegicus],ESTs, Highly similar to SET_HUMANSET PROTEIN [H. sapiens], SETtranslocation, SET translocation (myeloidleukemia-associated), nucleosomeassembly protein 1-like 175216007AF062594hhnucleosome assembly proteinESTs, Highly similar to 2008109A set1-like 1gene [Rattus norvegicus] [R. norvegicus],ESTs, Highly similar to SET_HUMANSET PROTEIN [H. sapiens], SETtranslocation, SET translocation (myeloidleukemia-associated), nucleosomeassembly protein 1-like 19267665AI030668anucleosome assembly proteinESTs, Highly similar to 2008109A set1-like 1gene [Rattus norvegicus] [R. norvegicus],ESTs, Highly similar to SET_HUMANSET PROTEIN [H. sapiens], SETtranslocation, SET translocation (myeloidleukemia-associated), nucleosomeassembly protein 1-like 1186213283NM_013078bornithineornithine carbamoyltransferase, ornithinecarbamoyltransferase,transcarbamylaseornithine transcarbamylase214121062NM_022585ggornithine decarboxylaseESTs, Weakly similar to ODCI_MOUSEantizyme inhibitorOrnithine decarboxylase antizymeinhibitor [M. musculus], ornithinedecarboxylase antizyme inhibitor214121063NM_022585f, y, zornithine decarboxylaseESTs, Weakly similar to ODCI_MOUSEantizyme inhibitorOrnithine decarboxylase antizymeinhibitor [M. musculus], ornithinedecarboxylase antizyme inhibitor233315840NM_031817h, losteomodulinosteoglycin, osteomodulin25154318NM_133306p, qoxidised low densityESTs, Weakly similar to JE0111 lectin-lipoprotein (lectin-like)like oxidized LDL receptor - mousereceptor 1, oxidized low[M. musculus], Mus musculus NKRP1Fdensity lipoprotein (lectin-like)mRNA, complete cds, killer cell lectin-receptor 1like receptor subfamily B member 1A,killer cell lectin-like receptor subfamily Bmember 1B, killer cell lectin-like receptorsubfamily B member 1C, killer cell lectin-like receptor subfamily B member 1D,oxidised low density lipoprotein (lectin-like) receptor 1, oxidized low densitylipoprotein (lectin-like) receptor 1169020549K01701boxytocin, oxytocin, prepro-ESTs, Moderately similar to NEU1(neurophysin I)MOUSE OXYTOCIN-NEUROPHYSIN 1PRECURSOR [M. musculus], oxytocin,oxytocin, prepro-(neurophysin I)22891918NM_031576ggP450 (cytochrome)oxidoreductase22891920NM_031576sP450 (cytochrome)oxidoreductase22891921NM_031576j, k, s, tP450 (cytochrome)oxidoreductase184324263NM_012999fpaired basic amino acidEST, Highly similar to I53282 genecleaving system 4, proproteinPACE4 protein - rat [R. norvegicus],convertase subtilisin/kexinRIKEN cDNA A930029K19 gene, pairedtype 6basic amino acid cleaving system 4,proprotein convertase subtilisin/kexintype 6184324264NM_012999gpaired basic amino acidEST, Highly similar to I53282 genecleaving system 4, proproteinPACE4 protein - rat [R. norvegicus],convertase subtilisin/kexinRIKEN cDNA A930029K19 gene, pairedtype 6basic amino acid cleaving system 4,proprotein convertase subtilisin/kexintype 6204611218NM_019247b, u, vpaired-like homeodomainESTs, Weakly similar to PIX3_RATtranscription factor 3Pituitary homeobox 3 (Homeobox proteinPTX3) [R. norvegicus], RIKEN cDNA1600026O01 gene,diencephalon/mesencephalon-expressed brain homeobox 1, newbornovary homeobox gene, paired-likehomeodomain transcription factor 3206618819NM_019367l, mpalmitoyl-protein thioesterase 2palmitoyl-protein thioesterase 2206618820NM_019367s, tpalmitoyl-protein thioesterase 2palmitoyl-protein thioesterase 220141581NM_017365l, p, q, s, tPDZ and LIM domain 1 (elfin)EST, Moderately similar toCL36_HUMAN LIM DOMAIN PROTEINCLP-36 [H. sapiens], ESTs, Weaklysimilar to PDL1_RAT PDZ and LIMdomain protein 1 (LIM domain proteinCLP-36) (C-terminal LIM domain protein1) (Elfin) [R. norvegicus], Mus musculus,clone MGC: 37634 IMAGE: 4990983,mRNA, complete cds, PDZ and LIMdomain 1 (elfin), PDZ and LIM domain 3,Rattus norvegicus LIM-domain proteinLMP-1 mRNA, complete cds, actininalpha 2 associated LIM protein197418148NM_017226n, opeptidyl arginine deiminase,ESTs, Highly similar to PROTEIN-type IIARGININE DEIMINASE [M. musculus],peptidyl arginine deiminase, type II197415108NM_017226u, vpeptidyl arginine deiminase,ESTs, Highly similar to PROTEIN-type IIARGININE DEIMINASE [M. musculus],peptidyl arginine deiminase, type II,ribosomal protein S1819394391NM_017101s, tpeptidylprolyl isomerase A,EST, Moderately similar to A Chain A,peptidylprolyl isomerase ACyclophilin A [H. sapiens], ESTs, Highly(cyclophilin A)similar to CYPH MOUSE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A[M. musculus], ESTs, Moderately similarto A Chain A, Human Cyclophilin AComplexed With 2-Thr Cyclosporin[H. sapiens], ESTs, Weakly similar to AChain A, Cyclophilin A [H. sapiens],ESTs, Weakly similar to A Chain A,Human Cyclophilin A Complexed With 2-Thr Cyclosporin [H. sapiens], ESTs,Weakly similar to CYPH_RAT Peptidyl-prolyl cis-trans isomerase A (PPlase)(Rotamase) (Cyclophilin A) (CyclosporinA-binding protein) (P31) [R. norvegicus],RIKEN cDNA 2510026K04 gene,expressed sequence AI256741,expressed sequence AW457192,peptidylprolyl isomerase A231015041NM_031678jj, kkperiod homolog 2EST, Weakly similar to period homolog(Drosophila)2 (Drosophila) [Rattus norvegicus][R. norvegicus], ESTs, Highly similar toperiod homolog 2 (Drosophila) [Rattusnorvegicus] [R. norvegicus], periodhomolog 1 (Drosophila), period homolog2 (Drosophila)19174500NM_017037iiperipheral myelin protein 22,peripheral myelin protein 22, peripheralperipheral myelin protein,myelin protein, 22 kDa22 kDa74522567AB017544aaperoxisomal biogenesis factorperoxisomal biogenesis factor 1414184820178NM_013014w, xpersephinEST, Weakly similar to persephin[Rattus norvegicus] [R. norvegicus],artemin, persephin229711296NM_031606fphosphatase and tensinESTs, Weakly similar to PTEN MOUSEhomolog, phosphatase andPROTEIN-TYROSINE PHOSPHATASEtensin homolog (mutated inPTEN [M. musculus], Mus musculus multiple advanced cancers 1)mRNA for tyrosine phosphatase (Tptegene), isoform A, splice variant A,phosphatase and tensin homolog,phosphatase and tensin homolog(mutated in multiple advanced cancers1), phosphatase and tensin homolog(mutated in multiple advanced cancers1), pseudogene 1197715598NM_017236iiphosphatidylethanolamineHomo sapiens, clone MGC: 22776binding protein, prostaticIMAGE: 4700840, mRNA, complete cds,binding proteinRIKEN cDNA 1700023A18 gene, RIKENcDNA 1700081D17 gene,phosphatidylethanolamine bindingprotein, prostatic binding protein197524598NM_017231hhphosphatidylinositol transferEST, Weakly similar to PPI1_RATprotein, phosphotidylinositolPHOSPHATIDYLINOSITOL TRANSFERtransfer proteinPROTEIN ALPHA ISOFORM (PTDINSTRANSFER PROTEIN ALPHA)(PTDINSTP) (PI-TP-ALPHA)[R. norvegicus], phosphatidylinositoltransfer protein, phosphotidylinositoltransfer protein, retinal degeneration B2homolog (Drosophila)2558945NM_138882j, k, s, tphosphatidylserine-specificESTs, Weakly similar to A34671phospholipase A1,triacylglycerol lipase [M. musculus],phosphatidylserine-specificESTs, Weakly similar to S15893phospholipase A1alphatriacylglycerol lipase [M. musculus],Homo sapiens membrane-boundphosphatidic acid-selectivephospholipase A1 mRNA, complete cds,expressed sequence AA986889, lipase,endothelial, pancreatic lipase-relatedprotein 26314250AA799729j, kphosphodiesterase 4B, cAMPphosphodiesterase 4B, cAMP specific,specific, phosphodiesterasephosphodiesterase 4B, cAMP-specific4B, cAMP-specific(phosphodiesterase E4 dunce homolog,(phosphodiesterase E4 dunceDrosophila), phosphodiesterase 9Ahomolog, Drosophila)191614247NM_017031h, lphosphodiesterase 4B, cAMPphosphodiesterase 4B, cAMP specific,specific, phosphodiesterasephosphodiesterase 4B, cAMP-specific4B, cAMP-specific(phosphodiesterase E4 dunce homolog,(phosphodiesterase E4 dunceDrosophila), phosphodiesterase 9Ahomolog, Drosophila)23201340NM_031715jj, kkphosphofructokinase, muscleESTs, Highly similar tophosphofructokinase, muscle;phosphofructokinase-1 A isozyme [Musmusculus] [M. musculus], expressedsequence AI131669,phosphofructokinase, muscle170112058L25387wphosphofructokinase, plateletESTs, Highly similar to K6PP_MOUSE 6-PHOSPHOFRUCTOKINASE, TYPE C(PHOSPHOFRUCTOKINASE 1)(PHOSPHOHEXOKINASE)(PHOSPHOFRUCTO-1-KINASEISOZYME C) (PFK-C) [M. musculus],ESTs, Moderately similar to A53047 6-phosphofructokinase [R. norvegicus],ESTs, Weakly similar to JC2055 6-phosphofructokinase [H. sapiens], ESTs,Weakly similar to K6PL MOUSE 6-PHOSPHOFRUCTOKINASE, LIVERTYPE [M. musculus],phosphofructokinase, platelet170125377L25387hhphosphofructokinase, platelet23651311NM_053291ephosphoglycerate kinase 1ESTs, Highly similar to A33792phosphoglycerate kinase (EC 2.7.2.3) -rat [R. norvegicus], phosphoglyceratekinase 1, phosphoglycerate kinase 2200324533NM_017328n, ophosphoglycerate mutase 2,EST, Weakly similar to PMGM MOUSEphosphoglycerate mutase 2PHOSPHOGLYCERATE MUTASE,(muscle)MUSCLE FORM [M. musculus], EST,Weakly similar to PMHUYMphosphoglycerate mutase [H. sapiens],phosphoglycerate mutase 2,phosphoglycerate mutase 2 (muscle)244611405NM_053866fphospholipase A2, activatingphospholipase A2, activating protein,protein, phospholipase A2-phospholipase A2-activating proteinactivating protein2528244NM_133551a, j, k, y,phospholipase A2, group IVAESTs, Highly similar to FGD1_HUMANz, ee, ff,(cytosolic, calcium-PUTATIVE RHO/RAC GUANINEkkdependent)NUCLEOTIDE EXCHANGE FACTOR[H. sapiens], ESTs, Weakly similar toB39898 phospholipase A2 [M. musculus],ESTs, Weakly similar to FGD1 MOUSEPUTATIVE RHO/RAC GUANINENUCLEOTIDE EXCHANGE FACTOR[M. musculus], ESTs, Weakly similar toFGD1_HUMAN PUTATIVE RHO/RACGUANINE NUCLEOTIDE EXCHANGEFACTOR [H. sapiens], FGD1 family,member 3, Homo sapiens cDNAFLJ32732 fis, clone TESTI2001141,highly similar to Rattus norvegicus actin-filament binding protein Frabin mRNA,Mus musculus actin-binding proteinfrabin-alpha mRNA, complete cds,RIKEN cDNA 2310026J01 gene, RIKENcDNA 2610311B01 gene, RIKEN cDNA5830461L01 gene, faciogenital dysplasiahomolog, hypothetical protein FLJ11183,phospholipase A2, group IVA (cytosolic,calcium-dependent), phospholipase A2,group IVB (cytosolic)19629378NM_017174jj, kkphospholipase A2, group Vphospholipase A2, group V218620933NM_024353h, lphospholipase C, beta 4Homo sapiens mRNA; cDNADKFZp434E235 (from cloneDKFZp434E235), phospholipase C, beta 12288546NM_031573h, iiphosphorylase kinaseESTs, Moderately similar togamma, phosphorylaseKPBG_HUMAN PHOSPHORYLASE Bkinase, gamma 1 (muscle)KINASE GAMMA CATALYTIC CHAIN,SKELETAL MUSCLE ISOFORM[H. sapiens], endoplasmic reticulum (ER)to nucleus signalling 2, phosphorylasekinase gamma, phosphorylase kinase,gamma 1 (muscle)924832AA800190a, e, ii,phosphorylase, glycogen;liver glycogen phosphorylase, musclekkbrainglycogen phosphorylase, phosphorylase,glycogen; brain25954834NM_153821h, lphosphorylase, glycogen;liver glycogen phosphorylase, musclebrainglycogen phosphorylase, phosphorylase,glycogen; brain242313369NM_053742n, ophosphotidylinositol transferESTs, Highly similar to PPI2_HUMANprotein, betaPHOSPHATIDYLINOSITOL TRANSFERPROTEIN BETA ISOFORM [H. sapiens],phosphotidylinositol transfer protein,beta8721332AI013222eplatelet derived growth factor,platelet derived growth factor, alpha,alpha, platelet-derived growthplatelet-derived growth factor alphafactor alpha polypeptidepolypeptide207415911NM_019907cc, ddpostsynaptic protein CRIPT,postsynaptic protein Cript199582NM_017297iipotassium inwardly-rectifyingpotassium inwardly-rectifying channel,channel, subfamily J, member 5subfamily J, member 5193815517NM_017099cpotassium inwardly-rectifyingpotassium inwardly-rectifying channel,channel, subfamily J, member 8subfamily J, member 819971028NM_017304iipotassium voltage-gatedpotassium voltage-gated channel,channel, shaker-relatedshaker-related subfamily, beta member 2subfamily, beta member 2109113267AI101847h, lpotassium voltage-gatedpotassium voltage-gated channel,channel, shaker-relatedshaker-related subfamily, member 5subfamily, member 5194015776NM_017108u, vpotassium voltage-gatedRIKEN cDNA C030044P22 gene,channel, subfamily H (eag-expressed sequence AU019351,related), member 3potassium voltage-gated channel,subfamily H (eag-related), member 3198216601NM_017252s, tPOU domain, class 3,POU domain, class 3, transcription factor 4transcription factor 425242788NM_133528s, tpreimplantation protein 3preimplantation protein 3236123895NM_033485aaPRKC, apoptosis, WT1,ESTs, Weakly similar to Ser/Arg-relatedregulatornuclear matrix protein; plenty-of-prolines-101; serine/arginine repetitive matrixprotein 1 [Mus musculus] [M. musculus],Mus musculus, Similar to hypotheticalprotein MGC13125, clone MGC: 38070IMAGE: 5252666, mRNA, complete cds,PRKC, apoptosis, WT1, regulator,expressed sequence AI480556,glucocorticoid-induced gene 1,serine/arginine repetitive matrix 1204315503NM_019237n, oprocollagen C-endopeptidaseEST, Weakly similar to PCO1_HUMANenhancer, procollagen C-PROCOLLAGEN C-PROTEINASEproteinase enhancer proteinENHANCER PROTEIN PRECURSOR[H. sapiens], ESTs, Weakly similar toPCO1_RAT Procollagen C-proteinaseenhancer protein precursor (PCPE)(Type I procollagen COOH-terminalproteinase enhancer) (Type 1procollagen C-proteinase enhancerprotein) [R. norvegicus], expressedsequence AI043106, membrane frizzled-related protein, procollagen C-endopeptidase enhancer, procollagen C-endopeptidase enhancer 2, procollagenC-proteinase enhancer protein184219393NM_012998h, lprocollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), betapolypeptide (protein disulfideisomerase; thyroid hormonebinding protein p55), prolyl 4-hydroxylase, beta polypeptide206820298NM_019374l, mprodynorphin208817936NM_021766d, r, ggprogesterone receptorHomo sapiens, clone MGC: 32124membrane component 1IMAGE: 4877960, mRNA, complete cds,RIKEN cDNA 4631434O19 gene,progesterone receptor membranecomponent 1210711454NM_022381d, l, m, n,proliferating cell nuclearproliferating cell nuclear antigeno, s, tantigen210711455NM_022381sproliferating cell nuclearproliferating cell nuclear antigenantigen184723545NM_013013l, mprosaposin, prosaposin(variant Gaucher disease andvariant metachromaticleukodystrophy)1776501NM_012704iiprostaglandin E receptor 3(subtype EP3)1776503NM_012704n, oprostaglandin E receptor 3(subtype EP3)204521108NM_019243fprostaglandin F2 receptorRIKEN cDNA 4833439O17 gene,negative regulatorimmunoglobulin superfamily, member 2,immunoglobulin superfamily, member 3,immunoglobulin superfamily, member 8,prostaglandin F2 receptor negativeregulator2285692NM_031557s, t, llprostaglandin I2EST, Highly similar to PTGI_RAT(prostacyclin) synthaseProstacyclin synthase (Prostaglandin I2synthase) [R. norvegicus], cytochromeP450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1,prostaglandin I2 (prostacyclin) synthase197620193NM_017232p, qprostaglandin-endoperoxideprostaglandin-endoperoxide synthase 2,synthase 2, prostaglandin-prostaglandin-endoperoxide synthase 2endoperoxide synthase 2(prostaglandin G/H synthase and(prostaglandin G/H synthasecyclooxygenase)and cyclooxygenase)199115142NM_017278l, mproteasome (prosome,proteasome (prosome, macropain)macropain) subunit, alphasubunit, alpha type 1, proteasometype 1, proteasome (prosome,(prosome, macropain) subunit, alphamacropain) subunit, alphatype, 1type, 119018673AA849028tproteasome (prosome,EST, Weakly similar to SNHUC8macropain) subunit, alphamulticatalytic endopeptidase complextype 3, proteasome (prosome,[H. sapiens], ESTs, Highly similar tomacropain) subunit, alphaPRC8 MOUSE PROTEASOMEtype, 3COMPONENT C8 [M. musculus], ESTs,Weakly similar to PRC8 MOUSEPROTEASOME COMPONENT C8[M. musculus], proteasome (prosome,macropain) subunit, alpha type 3,proteasome (prosome, macropain)subunit, alpha type, 3199215538NM_017283rproteasome (prosome,ESTs, Highly similar to S30274macropain) subunit, alphamulticatalytic endopeptidase complextype 6, proteasome (prosome,[H. sapiens], ESTs, Weakly similar tomacropain) subunit, alphaJX0230 multicatalytic endopeptidasetype, 6complex (EC 3.4.99.46) iota chain - rat[R. norvegicus], proteasome (prosome,macropain) subunit, alpha type 616629029D30804hhproteasome (prosome,EST, Highly similar to PSA7_HUMANmacropain) subunit, alphaPROTEASOME SUBUNIT ALPHA TYPEtype 7, proteasome (prosome,7 (PROTEASOME SUBUNIT RC6-1)macropain) subunit, alpha(PROTEASOME SUBUNIT XAPC7)type, 7[H. sapiens], EST, Highly similar toS60038 multicatalytic endopeptidasecomplex (EC 3.4.99.46) alpha chain RC6I - rat [R. norvegicus], Homo sapiens,similar to Proteasome subunit alpha type7 (Proteasome subunit RC6-1), cloneMGC: 26605 IMAGE: 4829939, mRNA,complete cds, RIKEN cDNA2410072D24 gene, proteasome(prosome, macropain) subunit, alphatype 7, proteasome (prosome,macropain) subunit, alpha type, 717774003NM_012708eproteasome (prosome,proteasome (prosome, macropain)macropain) subunit, betasubunit, beta type, 9 (largetype, 9 (large multifunctionalmultifunctional protease 2), proteosomeprotease 2), proteosome(prosome, macropain) subunit, beta type(prosome, macropain)9 (large multifunctional protease 2)subunit, beta type 9 (largemultifunctional protease 2)234617601NM_031976a, jj, kkprotein kinase, AMP-expressed sequence AW049591, proteinactivated, beta 1 non-catalytickinase, AMP-activated, beta 1 non-subunitcatalytic subunit185921287NM_013065l, mprotein phosphatase 1,protein phosphatase 1, catalytic subunit,catalytic subunit, beta isoformbeta isoform25039633NM_130403jj, kkprotein phosphatase 1,RIKEN cDNA 2010107K19 gene, RIKENregulatory (inhibitor) subunitcDNA 4933415F23 gene, protein14Aphosphatase 1, regulatory (inhibitor)subunit 14A, protein phosphatase 1,regulatory (inhibitor) subunit 14B, proteinphosphatase 1, regulatory (inhibitor)subunit 14C, protein phosphatase 1,regulatory (inhibitor) subunit 14c214824564NM_022676fprotein phosphatase 1,EST, Weakly similar to IPP1_HUMANregulatory (inhibitor) subunitPROTEIN PHOSPHATASE INHIBITOR1A1 [H. sapiens], ESTs, Moderately similarto PROTEIN PHOSPHATASEINHIBITOR 1 [R. norvegicus], Musmusculus, clone MGC: 18770IMAGE: 4164563, mRNA, complete cds,RIKEN cDNA 4930565M23 gene, proteinphosphatase 1 regulatory subunit 1A,protein phosphatase 1, regulatory(inhibitor) subunit 1A19183203NM_017039cprotein phosphatase 2protein phosphatase 2 (formerly 2A),(formerly 2A), catalyticcatalytic subunit, alpha isoform, proteinsubunit, alpha isoform,phosphatase 2a, catalytic subunit, alphaprotein phosphatase 2a,isoformcatalytic subunit, alphaisoform191924597NM_017040b, l, m, u, vprotein phosphatase 2Mus musculus adult female placenta(formerly 2A), catalyticcDNA, RIKEN full-length enriched library,subunit, beta isoform, proteinclone: 1600017J22: protein phosphatasephosphatase 2a, catalytic2a, catalytic subunit, beta isoform, fullsubunit, beta isoforminsert sequence, protein phosphatase 2(formerly 2A), catalytic subunit, betaisoform, protein phosphatase 2a,catalytic subunit, beta isoform229224219NM_031579d, p, q, y,protein tyrosine phosphataseprotein tyrosine phosphatase 4a1,z, kk4a1, protein tyrosineprotein tyrosine phosphatase 4a3,phosphatase type IVA,protein tyrosine phosphatase type IVA,member 1member 1, protein tyrosine phosphatasetype IVA, member 317671841NM_012637d, jj, kkprotein tyrosine phosphatase,EST, Moderately similar to A34845non-receptor type 1protein-tyrosine-phosphatase (EC3.1.3.48), nonreceptor type 1B - rat[R. norvegicus], ESTs, Moderately similarto PTN1_HUMAN PROTEIN-TYROSINEPHOSPHATASE, NON-RECEPTORTYPE 1 [H. sapiens], protein tyrosinephosphatase, non-receptor type 117671844NM_012637p, q, y, zprotein tyrosine phosphatase,EST, Moderately similar to A34845non-receptor type 1protein-tyrosine-phosphatase (EC3.1.3.48), nonreceptor type 1B - rat[R. norvegicus], ESTs, Moderately similarto PTN1_HUMAN PROTEIN-TYROSINEPHOSPHATASE, NON-RECEPTORTYPE 1 [H. sapiens], protein tyrosinephosphatase, non-receptor type 1202114973NM_019140aaprotein tyrosine phosphatase,ESTs, Weakly similar to 2103274Areceptor type, Dreceptor type protein Tyr phosphatase[M. musculus], RIKEN cDNA1600019O04 gene, expressed sequenceAU040377, protein tyrosinephosphatase, receptor type, S208522916NM_021740iiprothymosin alpha,ESTs, Highly similar to THYA_HUMANprothymosin, alpha (genePROTHYMOSIN ALPHA [H. sapiens],sequence 28)RIKEN cDNA 2610009E16 gene,prothymosin alpha, prothymosin, alpha(gene sequence 28)15104716AI232313c, rpurinergic receptor P2X,purinergic receptor P2X, ligand-gated ionligand-gated ion channel 4,channel 4, purinergic receptor P2X,purinergic receptor P2X,ligand-gated ion channel, 4ligand-gated ion channel, 42499363NM_080780d, e, p,purinergic receptor P2X,purinergic receptor P2X, ligand-gated ionq, ee, ffligand-gated ion channel, 5channel, 519831496NM_017255aa, bbpurinergic receptor P2Y, G-G protein-coupled receptor 31, G protein-protein coupled 2, purinergiccoupled receptor 35, Mus musculus,receptor P2Y, G-proteinclone MGC: 28142 IMAGE: 3982042,coupled, 2mRNA, complete cds, RIKEN cDNA2610302I02 gene, RIKEN cDNA5830408N17 gene, expressed sequenceAI662791, purinergic receptor P2Y, G-protein coupled 2, purinergic receptorP2Y, G-protein coupled, 222081928NM_030872s, tpyruvate dehydrogenase 2,Mus musculus, Similar to pyruvatepyruvate dehydrogenasedehydrogenase kinase, isoenzyme 1,kinase, isoenzyme 2clone MGC: 28719 IMAGE: 4458562,mRNA, complete cds, Mus musculus,Similar to pyruvate dehydrogenasekinase, isoenzyme 3, clone MGC: 6383IMAGE: 3500763, mRNA, complete cds,pyruvate dehydrogenase 2, pyruvatedehydrogenase kinase, isoenzyme 222081929NM_030872hhpyruvate dehydrogenase 2,Mus musculus, Similar to pyruvatepyruvate dehydrogenasedehydrogenase kinase, isoenzyme 1,kinase, isoenzyme 2clone MGC: 28719 IMAGE: 4458562,mRNA, complete cds, Mus musculus,Similar to pyruvate dehydrogenasekinase, isoenzyme 3, clone MGC: 6383IMAGE: 3500763, mRNA, complete cds,pyruvate dehydrogenase 2, pyruvatedehydrogenase kinase, isoenzyme 2201220417NM_017359h, l, hhRAB10, member RASESTs, Weakly similar to RAB8_HUMANoncogene familyRAS-RELATED PROTEIN RAB-8[H. sapiens], RAB10, member RASoncogene family, RAB12, member RASoncogene family, RAB38, member RASoncogene family, expressed sequenceAA536966, expressed sequenceAW107754184920229NM_013018kkRAB3A, member RASESTs, Weakly similar to C34323 GTP-oncogene familybinding protein Rab3A [H. sapiens],RAB3A, member RAS oncogene family223118307NM_031091w, xRAB3B, member RASRAB3B, member RAS oncogene familyoncogene family223118308NM_031091w, xRAB3B, member RASRAB3B, member RAS oncogene familyoncogene family21336577NM_022532u, vraf-related oncogene, v-rafMus musculus adult male lung cDNA,murine sarcoma 3611 viralRIKEN full-length enriched library,oncogene homolog 1clone: 1200013E08: raf-related oncogene,full insert sequence, expressedsequence AW495444, raf-relatedoncogene, v-raf murine sarcoma 3611viral oncogene homolog 1235121807NM_032067ggRal-interacting protein 1, ralARal-interacting protein 1, ralA bindingbinding protein 1protein 1235121809NM_032067llRal-interacting protein 1, ralARal-interacting protein 1, ralA bindingbinding protein 1protein 1166125278D30734ggRAS p21 protein activator 2154722152AI234822j, kRAS, dexamethasone-Mus musculus small GTP-binding tumorinduced 1suppressor 1 (Gbts1) mRNA, completecds, Mus musculus, Similar to RAP1A,member of RAS oncogene family, cloneMGC: 18653 IMAGE: 3600519, mRNA,complete cds, RAP2B, member of RASoncogene family, RAS, dexamethasone-induced 1, RIKEN cDNA 1110065D03gene, RIKEN cDNA 2010200P20 gene,RIKEN cDNA 5830461H18 gene, rap2A-like protein, ras homolog gene family,member I189823362NM_013216eRAS-homolog enriched inESTs, Weakly similar to RALA MOUSEbrain, Ras homolog enrichedRAS-RELATED PROTEIN RAL-Ain brain 2[M. musculus], RAS-homolog enriched inbrain, RIKEN cDNA 1810036J22 gene,Ras homolog enriched in brain 2, ras-likeprotein VTS5863523731609NM_053338j, p, q, y, zRas-related associated withESTs, Weakly similar to Ras-relateddiabetesassociated with diabetes [Rattusnorvegicus] [R. norvegicus], GTP bindingprotein (gene overexpressed in skeletalmuscle), GTP binding proteinoverexpressed in skeletal muscle, Ras-related associated with diabetes, rad andgem related GTP binding protein230516062NM_031646n, oreceptor (calcitonin) activityreceptor (calcitonin) activity modifyingmodifying protein 2protein 220622088NM_019341aa, bbregulator of G-proteinregulator of G-protein signaling 5,signaling 5, regulator of G-regulator of G-protein signalling 5protein signalling 5194720916NM_017132dreticulocalbin 2, reticulocalbinESTs, Weakly similar to I56519 taipoxin-2, EF-hand calcium bindingassociated calcium binding protein-49domainprecursor - rat [R. norvegicus],calumenin, reticulocalbin, reticulocalbin2, reticulocalbin 2, EF-hand calciumbinding domain165817264D25233dretinoblastoma 1, EST, Moderately similar toretinoblastoma 1 (includingRETINOBLASTOMA-ASSOCIATEDosteosarcoma)PROTEIN [M. musculus], ESTs, Highlysimilar to RB MOUSERETINOBLASTOMA-ASSOCIATEDPROTEIN [M. musculus], retinoblastoma1, retinoblastoma 1 (includingosteosarcoma)14191377AI227715a, ee, ffretinoblastoma-like 2, Mus musculus 11 days embryo wholeretinoblastoma-like 2 (p130)body cDNA, RIKEN full-length enrichedlibrary, clone: 2700054A06: retinoblastoma-like 1(p107), full insert sequence, retinoblastoma-like 1 (p107), retinoblastoma-like 2, retinoblastoma-like2 (p130)22331376NM_031094iiretinoblastoma-like 2, Mus musculus 11 days embryo wholeretinoblastoma-like 2 (p130)body cDNA, RIKEN full-length enrichedlibrary, clone: 2700054A06: retinoblastoma-like 1(p107), full insert sequence, retinoblastoma-like 1 (p107), retinoblastoma-like 2, retinoblastoma-like2 (p130)178223806NM_012733j, kretinol binding protein 1, ESTs, Weakly similar to RET1_RATcellularRetinol-binding protein I, cellular(Cellular retinol-binding protein) (CRBP)[R. norvegicus], retinoid binding protein 7, retinol binding protein 1, cellular, retinolbinding protein 5, cellular, retinol bindingprotein 7, cellular18501338NM_013022rRho-associated coiled-coilRho-associated coiled-coil formingforming kinase 2, Rho-kinase 2, Rho-associated, coiled-coilassociated, coiled-coilcontaining protein kinase 2, expressedcontaining protein kinase 2sequence AU014939231421575NM_031698w, xribophorin IIEST, Moderately similar toRIB2_HUMAN DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE -PROTEIN GLYCOSYLTRANSFERASE63 KDA SUBUNIT PRECURSOR[H. sapiens], ESTs, Moderately similar toRIB2_HUMAN DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE -PROTEIN GLYCOSYLTRANSFERASE63 KDA SUBUNIT PRECURSOR[H. sapiens], ribophorin 2, relatedsequence 1, ribophorin II222711849NM_031065h, l, n, oribosomal protein L10A, EST, Moderately similar to R10Aribosomal protein L10aMOUSE 60S RIBOSOMAL PROTEINL10A [M. musculus], ribosomal proteinL10A, ribosomal protein L10a223723854NM_031101f, w, x, llribosomal protein L13EST, Moderately similar to JC2368ribosomal protein L13, cytosolic[validated] - rat [R. norvegicus], EST, Weakly similar to JC2368 ribosomalprotein L13, cytosolic [validated] - rat[R. norvegicus], ESTs, Highly similar toribosomal protein L13; 60S ribosomalprotein L13; breast basic conservedprotein 1 [Homo sapiens] [H. sapiens], ESTs, Moderately similar to RL13MOUSE 60S RIBOSOMAL PROTEINL13 [M. musculus], Homo sapiens cDNAFLJ30941 fis, clone FEBRA2007458, Human RPL13-2 pseudogene mRNA, complete cds, ribosomal protein L13223820462NM_031102h, lribosomal protein L18ESTs, Weakly similar to 60SRIBOSOMAL PROTEIN L18[M. musculus], ribosomal protein L18223916938NM_031103gribosomal protein L19EST, Weakly similar to RL19 MOUSE60S RIBOSOMAL PROTEIN L19[M. musculus], ESTs, Weakly similar toRL19_HUMAN 60S RIBOSOMALPROTEIN L1 [M. musculus], ESTs, Weakly similar to RL19_HUMAN 60Sribosomal protein L19 [R. norvegicus], ribosomal protein L19237114927NM_053330eribosomal protein L21EST, Moderately similar to 2113200Bribosomal protein L21 [H. sapiens], EST, Moderately similar to RL21_RAT 60SRIBOSOMAL PROTEIN L21[R. norvegicus], EST, Weakly similar to2113200B ribosomal protein L21[H. sapiens], EST, Weakly similar toRL21 MOUSE 60S RIBOSOMALPROTEIN L21 [M. musculus], EST, Weakly similar to RL21_HUMAN 60SRIBOSOMAL PROTEIN L21 [H. sapiens], ESTs, Highly similar to 2113200Bribosomal protein L21 [H. sapiens], ESTs, Highly similar to RL21 MOUSE 60SRIBOSOMAL PROTEIN L21[M. musculus], ESTs, Moderately similarto RL21 MOUSE 60S RIBOSOMALPROTEIN L21 [M. musculus], ribosomalprotein L21237114929NM_053330h, lribosomal protein L21EST, Moderately similar to 2113200Bribosomal protein L21 [H. sapiens], EST, Moderately similar to RL21_RAT 60SRIBOSOMAL PROTEIN L21[R. norvegicus], EST, Weakly similar to2113200B ribosomal protein L21[H. sapiens], EST, Weakly similar toRL21 MOUSE 60S RIBOSOMALPROTEIN L21 [M. musculus], EST, Weakly similar to RL21_HUMAN 60SRIBOSOMAL PROTEIN L21 [H. sapiens], ESTs, Highly similar to 2113200Bribosomal protein L21 [H. sapiens], ESTs, Highly similar to RL21 MOUSE 60SRIBOSOMAL PROTEIN L21[M. musculus], ESTs, Moderately similarto RL21 MOUSE 60S RIBOSOMALPROTEIN L21 [M. musculus], ribosomalprotein L2126585667X58200h, l, w, xribosomal protein L2321252696NM_022515cc, ddribosomal protein L24Homo sapiens, clone MGC: 27044IMAGE: 4793412, mRNA, complete cds, Mus musculus, Similar to 60S ribosomalprotein L30 isolog, clone MGC: 6735IMAGE: 3590401, mRNA, complete cds, ribosomal protein L2421252697NM_022515f, g, ggribosomal protein L24Homo sapiens, clone MGC: 27044IMAGE: 4793412, mRNA, complete cds, Mus musculus, Similar to 60S ribosomalprotein L30 isolog, clone MGC: 6735IMAGE: 3590401, mRNA, complete cds, ribosomal protein L2421243027NM_022514w, xribosomal protein L27ribosomal protein L27215217729NM_022697f, g, w, x, ribosomal protein L28ribosomal protein L28cc, dd265818611X58200gribosomal protein L29EST, Moderately similar toRL29_HUMAN 60S RIBOSOMALPROTEIN L29 [H. sapiens], EST, Moderately similar to RL29_RAT 60SRIBOSOMAL PROTEIN L29 (P23)[R. norvegicus], ESTs, Highly similar toS65784 ribosomal protein L29, cytosolic[H. sapiens], ribosomal protein L29207815335NM_021264wribosomal protein L35a21204259NM_022504f, gribosomal protein L36EST, Moderately similar to ribosomalprotein L36 [Rattus norvegicus][R. norvegicus], RIKEN cDNA1110038G14 gene, ribosomal proteinL36256415380NM_139083u, v, cc, ribosomal protein L41ESTs, Highly similar to YZA1_HUMANddHYPOTHETICAL PROTEIN [H. sapiens], ribosomal protein L41266615875X62145h, rribosomal protein L8EST, Highly similar to RL8_HUMAN 60Sribosomal protein L8 [R. norvegicus], EST, Weakly similar to JN0923ribosomal protein L8, cytosolic[H. sapiens], ESTs, Highly similar toR5RTL8 ribosomal protein L8, cytosolic[validated] - rat [R. norvegicus], ESTs, Highly similar to RL8_HUMAN 60SRIBOSOMAL PROTEIN L [M. musculus], ESTs, Moderately similar toRL8_HUMAN 60S RIBOSOMALPROTEIN L [M. musculus], expressedsequence AL024098, ribosomal proteinL8265018250X51706w, xribosomal protein L9EST, Moderately similar to S65792ribosomal protein L9, cytosolic[H. sapiens], EST, Weakly similar toRL9_RAT 60S RIBOSOMAL PROTEINL9 [R. norvegicus], ESTs, Weakly similarto 60S RIBOSOMAL PROTEIN L9[M. musculus], RIKEN cDNA4930401B11 gene, ribosomal protein L9265320427X53378hribosomal protein S13ESTs, Moderately similar toRS13_HUMAN 40S RIBOSOMALPROTEIN S13 [H. sapiens], ribosomalprotein S13195516953NM_017151gribosomal protein S15EST, Moderately similar to R3HU15ribosomal protein S15, cytosolic[H. sapiens], ESTs, Highly similar toRS15_HUMAN 40S RIBOSOMALPROTEIN S15 [M. musculus], ribosomalprotein S15195516954NM_017151ggribosomal protein S15EST, Moderately similar to R3HU15ribosomal protein S15, cytosolic[H. sapiens], ESTs, Highly similar toRS15_HUMAN 40S RIBOSOMALPROTEIN S15 [M. musculus], ribosomalprotein S15195516955NM_017151l, m, s, tribosomal protein S15EST, Moderately similar to R3HU15ribosomal protein S15, cytosolic[H. sapiens], ESTs, Highly similar toRS15_HUMAN 40S RIBOSOMALPROTEIN S15 [M. musculus], ribosomalprotein S15264815626X17665w, xribosomal protein S16EST AI317031, EST, Weakly similar toR3HU16 ribosomal protein S16, cytosolic[H. sapiens], expressed sequenceAA420385, ribosomal protein S16265120872X51707l, w, xribosomal protein S19EST, Moderately similar to R3RT19ribosomal protein S19, cytosolic[validated] - rat [R. norvegicus], EST, Weakly similar to RS19_HUMAN 40SRIBOSOMAL PROTEIN S19 [H. sapiens]249210498NM_078617c, g, w, xribosomal protein S23ESTs, Highly similar to 40SRIBOSOMAL PROTEIN S23 [H. sapiens], ESTs, Weakly similar to ribosomalprotein S23 [Rattus norvegicus][R. norvegicus], Mus musculus, Similar tomitochondrial ribosomal protein S12, clone MGC: 13892 IMAGE: 4209358, mRNA, complete cds, mitochondrialribosomal protein S12, ribosomal proteinS23224620839NM_031113w, xribosomal protein S27aESTs, Highly similar to ribosomalprotein S27a [Mus musculus][M. musculus], ESTs, Highly similar toubiquitin/ribosomal protein S27a[H. sapiens], ESTs, Weakly similar toribosomal protein S27a [Rattusnorvegicus] [R. norvegicus], Musmusculus, Similar to ubiquitin-like 4, clone MGC: 19132 IMAGE: 4215699, mRNA, complete cds, neural precursorcell expressed, developmentally down-regulated 8, ribosomal protein S27a181317305NM_012876g, hhribosomal protein S29EST, Moderately similar toRS29_HUMAN 40S RIBOSOMALPROTEIN S29 [M. musculus], ESTs, Weakly similar to RS29_HUMAN 40SRIBOSOMAL PROTEIN S29 [H. sapiens], ribosomal protein S29181317306NM_012876fribosomal protein S29EST, Moderately similar toRS29_HUMAN 40S RIBOSOMALPROTEIN S29 [M. musculus], ESTs, Weakly similar to RS29_HUMAN 40SRIBOSOMAL PROTEIN S29 [H. sapiens], ribosomal protein S29264910819X51536ggribosomal protein S3EST, Moderately similar to RS3_MOUSE40S ribosomal protein S3 [R. norvegicus], EST, Weakly similar to RS3_MOUSE40S ribosomal protein S3 [R. norvegicus], ESTs, Highly similar to RS3_MOUSE40S ribosomal protein S3 [R. norvegicus], ESTs, Moderately similar toRS3_HUMAN 40S RIBOSOMALPROTEIN S [H. sapiens], ESTs, Weaklysimilar to RS3 MOUSE 40SRIBOSOMAL PROTEIN S3[M. musculus], hypothetical proteinFLJ11252, hypothetical proteinFLJ23059, myo-inositol 1-phosphatesynthase A1, ribosomal protein S3264925686X51536w, x, hhribosomal protein S3265925702X58465g, w, xribosomal protein S5EST, Moderately similar to 2113200Eribosomal protein S5 [H. sapiens], EST, Weakly similar to 2113200E ribosomalprotein S5 [H. sapiens], ribosomal proteinS5265910109X58465g, w, xribosomal protein S5EST, Moderately similar to 2113200Eribosomal protein S5 [H. sapiens], EST,Weakly similar to 2113200E ribosomalprotein S5 [H. sapiens], ribosomal proteinS5195717104NM_017160h, lribosomal protein S6EST, Moderately similar to R3HU6ribosomal protein S6, cytosolic[H. sapiens], EST, Moderately similar toRS6_HUMAN 40S RIBOSOMALPROTEIN S6 [H. sapiens], EST, Weaklysimilar to R3HU6 ribosomal protein S6,cytosolic [H. sapiens], ESTs, Highlysimilar to RS6_HUMAN 40SRIBOSOMAL PROTEIN S6 [H. sapiens],ESTs, Weakly similar to RS6_HUMAN40S RIBOSOMAL PROTEIN S6[H. sapiens], ribosomal protein S6195717105NM_017160h, lribosomal protein S6EST, Moderately similar to R3HU6ribosomal protein S6, cytosolic[H. sapiens], EST, Moderately similar toRS6_HUMAN 40S RIBOSOMALPROTEIN S6 [H. sapiens], EST, Weaklysimilar to R3HU6 ribosomal protein S6,cytosolic [H. sapiens], ESTs, Highlysimilar to RS6_HUMAN 40SRIBOSOMAL PROTEIN S6 [H. sapiens],ESTs, Weakly similar to RS6_HUMAN40S RIBOSOMAL PROTEIN S6[H. sapiens], ribosomal protein S6195717106NM_017160n, oribosomal protein S6EST, Moderately similar to R3HU6ribosomal protein S6, cytosolic[H. sapiens], EST, Moderately similar toRS6_HUMAN 40S RIBOSOMALPROTEIN S6 [H. sapiens], EST, Weaklysimilar to R3HU6 ribosomal protein S6,cytosolic [H. sapiens], ESTs, Highlysimilar to RS6_HUMAN 40SRIBOSOMAL PROTEIN S6 [H. sapiens],ESTs, Weakly similar to RS6_HUMAN40S RIBOSOMAL PROTEIN S6[H. sapiens], ribosomal protein S622879620NM_031570w, x, cc,ribosomal protein S7EST, Moderately similar to JC4388ddribosomal protein S7, cytosolic[H. sapiens], EST, Weakly similar toRS7_HUMAN 40S RIBOSOMALPROTEIN S7 [M. musculus], EST,Weakly similar to RS7_HUMAN 40Sribosomal protein S7 (S8)[R. norvegicus], ESTs, Highly similar toJC4388 ribosomal protein S7, cytosolic[H. sapiens], ESTs, Highly similar toRS7_HUMAN 40S RIBOSOMALPROTEIN S7 [H. sapiens], ESTs,Moderately similar to RS7_HUMAN 40SRIBOSOMAL PROTEIN S7 [H. sapiens],ribosomal protein S7231516204NM_031706f, g, jj, kkribosomal protein S8EST, Weakly similar to 40SRIBOSOMAL PROTEIN S8[M. musculus], ESTs, Highly similar toS25022 ribosomal protein S8, cytosolic[H. sapiens], ESTs, Moderately similar toRS8_HUMAN 40S RIBOSOMALPROTEIN S [H. sapiens], RIKEN cDNA1110008P08 gene, ribosomal protein S8231516205NM_031706jj, kkribosomal protein S8EST, Weakly similar to 40SRIBOSOMAL PROTEIN S8[M. musculus], ESTs, Highly similar toS25022 ribosomal protein S8, cytosolic[H. sapiens], ESTs, Moderately similar toRS8_HUMAN 40S RIBOSOMALPROTEIN S [H. sapiens], RIKEN cDNA1110008P08 gene, ribosomal protein S86418061AA799735rRuvB-like 1 (E. coli), RuvB-Homer, neuronal immediate early gene,like protein 11B, homer, neuronal immediate earlygene, 1231618054NM_031707f, g, n, oRuvB-like 1 (E. coli), RuvB-Homer, neuronal immediate early gene,like protein 11B, homer, neuronal immediate earlygene, 1231618057NM_031707rRuvB-like 1 (E. coli), RuvB-Homer, neuronal immediate early gene,like protein 11B, homer, neuronal immediate earlygene, 1231618059NM_031707p, q, ee,RuvB-like 1 (E. coli), RuvB-Homer, neuronal immediate early gene,fflike protein 11B, homer, neuronal immediate earlygene, 1224719040NM_031114a, c, h, l, S100 calcium binding proteinEST, Moderately similar to S110_RATy, ee, ffA10 (annexin II ligand,Calpactin I light chain (P10 protein)calpactin I, light polypeptide(P11) (Cellular ligand of annexin II)(p11)), S100 calcium binding(Nerve growth factor induced proteinprotein A10 (calpactin)42C) [R. norvegicus], S100 calciumbinding protein A10 (annexin II ligand,calpactin I, light polypeptide (p11)), S100calcium binding protein A10 (calpactin)176420589NM_012618h, l, n, o,S100 calcium binding proteinS100 calcium binding protein A2, S100w, xA4, S100 calcium bindingcalcium binding protein A4 (calciumprotein A4 (calcium protein,protein, calvasculin, metastasin, murinecalvasculin, metastasin,placental homolog)murine placental homolog)238616394NM_053485h, l, w, xS100 calcium binding proteinA6 (calcyclin)196720779NM_017201b, l, mS-adenosylhomocysteineMus musculus, S-adenosylhomocysteinehydrolasehydrolase-like 1, clone MGC: 18748IMAGE: 4007102, mRNA, complete cds,S-adenosylhomocysteine hydrolase, S-adenosylhomocysteine hydrolase,related sequence 3, expressedsequence AL024110221415682NM_031011n, oS-adenosylmethionineS-adenosylmethionine decarboxylase 1,decarboxylase 1S-adenosylmethionine decarboxylase 2221415683NM_031011cc, dd,S-adenosylmethionineS-adenosylmethionine decarboxylase 1,ggdecarboxylase 1S-adenosylmethionine decarboxylase 2177016217NM_012656c, aa, bbsecreted acidic cysteine richsecreted acidic cysteine richglycoprotein, secretedglycoprotein, secreted protein, acidic,protein, acidic, cysteine-richcysteine-rich (osteonectin)(osteonectin)177016218NM_012656n, osecreted acidic cysteine richsecreted acidic cysteine richglycoprotein, secretedglycoprotein, secreted protein, acidic,protein, acidic, cysteine-richcysteine-rich (osteonectin)(osteonectin)177016219NM_012656r, ggsecreted acidic cysteine richsecreted acidic cysteine richglycoprotein, secretedglycoprotein, secreted protein, acidic,protein, acidic, cysteine-richcysteine-rich (osteonectin)(osteonectin)177016220NM_012656h, l, aa,secreted acidic cysteine richsecreted acidic cysteine richbbglycoprotein, secretedglycoprotein, secreted protein, acidic,protein, acidic, cysteine-richcysteine-rich (osteonectin)(osteonectin)177016221NM_012656dsecreted acidic cysteine richsecreted acidic cysteine richglycoprotein, secretedglycoprotein, secreted protein, acidic,protein, acidic, cysteine-richcysteine-rich (osteonectin)(osteonectin)181423651NM_012881h, l, n, o,secreted phosphoprotein 1,w, xsecreted phosphoprotein 1(osteopontin, bonesialoprotein I, early T-lymphocyte activation 1)185117894NM_013027ggselenoprotein W, 1,ESTs, Weakly similar to SELW MOUSEselenoprotein W, muscle 1SELENOPROTEIN W [M. musculus],selenoprotein W, 1, selenoprotein W,muscle 1171821400M36410ee, ff, ggsepiapterin reductase,ESTs, Highly similar to A36024sepiapterin reductase (7,8-sepiapterin reductase (EC 1.1.1.153)-dihydrobiopterin: NADP+rat [R. norvegicus], sepiapterinoxidoreductase)reductase, sepiapterin reductase (7,8-dihydrobiopterin: NADP+ oxidoreductase)176515540NM_012620a, kkserine (or cysteine)proteinase inhibitor, clade E(nexin, plasminogen activatorinhibitor type 1), member 1196117301NM_017173c, f, g, j,serine (or cysteine)serine (or cysteine) proteinase inhibitor,k, y, zproteinase inhibitor, clade Hclade H (heat shock protein 47), member(heat shock protein 47),1, serine (or cysteine) proteinasemember 1, serine (orinhibitor, clade H (heat shock proteincysteine) proteinase inhibitor,47), member 1, (collagen binding proteinclade H (heat shock protein1), serine (or cysteine) proteinase47), member 1, (collageninhibitor, clade H (heat shock proteinbinding protein 1)47), member 2232215507NM_031735userine/threonine kinase 3serine/threonine kinase 24 (STE20(STE20 homolog, yeast),homolog, yeast), serine/threonine kinaseserine/threonine kinase 325 (STE20 homolog, yeast),(Ste20, yeast homolog)serine/threonine kinase 25 (yeast),serine/threonine kinase 3 (STE20homolog, yeast), serine/threonine kinase3 (Ste20, yeast homolog),serine/threonine kinase 4204220433NM_019232p, q, kkserum/glucocorticoidEST, Weakly similar to SGK_RATregulated kinaseSerine/threonine-protein kinase Sgk(Serum/glucocorticoid-regulated kinase)[R. norvegicus], Mus musculus,hypothetical protein MGC11287 similarto ribosomal protein S6 kinase,, cloneMGC: 38756 IMAGE: 5358742, mRNA,complete cds, RIKEN cDNA1190006F07 gene, serine/threonineprotein kinase CISK,serum/glucocorticoid regulated kinase,serum/glucocorticoid regulated kinase 2,serum/glucocorticoid regulated kinase-like23342655NM_031821dserum-inducible kinaseESTs, Highly similar to SNK_RATSerine/threonine-protein kinase SNK(Serum inducible kinase) [R. norvegicus],ESTs, Weakly similar to SNK MOUSESERINE/THREONINE-PROTEINKINASE SNK [M. musculus], ESTs,Weakly similar to SNK_RATSerine/threonine-protein kinase SNK(Serum inducible kinase) [R. norvegicus],Homo sapiens cDNA FLJ30246 fis, cloneBRACE2002202, weakly similar toSERINE/THREONINE-PROTEINKINASE SNK (EC 2.7.1.—), NIMA (neverin mitosis gene a)-related expressedkinase 1, NIMA (never in mitosis gene a)-related kinase 4, serum-inducible kinase19669124NM_017199h, l, hhsignal sequence receptor,EST, Moderately similar to SSRD_RATdelta, signal sequenceTRANSLOCON-ASSOCIATEDreceptor, delta (translocon-PROTEIN, DELTA SUBUNITassociated protein delta)PRECURSOR (TRAP-DELTA) (SIGNALSEQUENCE RECEPTOR DELTASUBUNIT) (SSR-DELTA) [R. norvegicus],EST, Weakly similar to SSRD_HUMANTRANSLOCON-ASSOCIATEDPROTEIN, DELTA SUBUNITPRECURSOR [H. sapiens], Musmusculus, clone IMAGE: 4038523,mRNA, partial cds, signal sequencereceptor, delta, signal sequencereceptor, delta (translocon-associatedprotein delta)216715727NM_022953u, vslit homolog 1 (Drosophila)EST, Highly similar to T42626 secretedleucine-rich repeat-containing proteinSLIT2—mouse (fragment) [M. musculus],ESTs, Weakly similar to hypotheticalprotein MGC7599; clone MGC: 7599[Mus musculus] [M. musculus], ESTs,Weakly similar to integral membraneglycoprotein [Mus musculus][M. musculus], ESTs, Weakly similar toALS MOUSE INSULIN-LIKE GROWTHFACTOR BINDING PROTEINCOMPLEX ACID LABILE CHAINPRECURSOR [M. musculus], ESTs,Weakly similar to JG0193 G protein-coupled receptor FEX - mouse[M. musculus], ESTs, Weakly similar toSlit-1 protein [H. sapiens], Mus musculus,Similar to leucine-rich repeat-containing3, clone MGC: 30505 IMAGE: 4481142,mRNA, complete cds, RIKEN cDNA9530074E10 gene, slit homolog 1(Drosophila), slit homolog 2 (Drosophila),slit homolog 3 (Drosophila)227720448NM_031530a, d, z,small inducible cytokine A2,EST, Weakly similar to S07723ee, ff, jj,small inducible cytokine A2immediate-early serum-responsivekk(monocyte chemotacticprotein JE precursor - rat [R. norvegicus],protein 1)expressed sequence AI323594, smallinducible cytokine A2, small induciblecytokine A24, small inducible cytokinesubfamily A (Cys-Cys), member 24227720449NM_031530a, z, ee, small inducible cytokine A2,EST, Weakly similar to S07723ff, kksmall inducible cytokine A2immediate-early serum-responsive(monocyte chemotacticprotein JE precursor - rat [R. norvegicus],protein 1)expressed sequence AI323594, smallinducible cytokine A2, small induciblecytokine A24, small inducible cytokinesubfamily A (Cys-Cys), member 24254519077NM_134455aa, bbsmall inducible cytokinesmall inducible cytokine subfamily Dsubfamily D (Cys-X3-Cys),(Cys-X3-Cys), member 1 (fractalkine,member 1 (fractalkine,neurotactin), small inducible cytokineneurotactin), small induciblesubfamily D, 1cytokine subfamily D, 1180120246NM_012807l, m, ssmoothened homologEST, Moderately similar to(Drosophila)SMO_HUMAN SMOOTHENEDHOMOLOG PRECURSOR [H. sapiens],smoothened homolog (Drosophila)199320579NM_017288aa, bbsodium channel, voltage-Mus musculus brain and heart sodiumgated, type I, betachannel beta 3 subunit mRNA, completepolypeptidecds, sodium channel beta 3 subunit,sodium channel, voltage-gated, type I,beta polypeptide166421147D63772j, k, psolute carrier family 1ESTs, Weakly similar to EAA3_RAT(neuronal/epithelial highExcitatory amino acid transporter 3affinity glutamate transporter,(Sodium-dependent glutamate/aspartatesystem Xag), member 1,transporter 3) (Excitatory amino-acidsolute carrier family 1,carrier 1) [R. norvegicus], Mus musculusmember 1adult male testis cDNA, RIKEN full-length enriched library,clone: 4931413K05: solute carrier family1, member 1, full insert sequence, Rattusnorvegicus mRNA for sodium-dependentneutral amino acid transporter, ASCT2,solute carrier family 1(neuronal/epithelial high affinityglutamate transporter, system Xag),member 1, solute carrier family 1,member 1, solute carrier family 1,member 722791005NM_031537l, msolute carrier family 11(proton-coupled divalentmetal ion transporters),member 123312114NM_031798aa, bbsolute carrier family 12Mus musculus strain ILS K-Cl(sodium/potassium/chloridecotransporter (Slc12a5) mRNA,transporters), member 2,complete cds, cation-chloridesolute carrier family 12,cotransporter 6, cation-chloridemember 2cotransporter 9, cation-chloridecotransporter-interacting protein 1,solute carrier family 12(sodium/potassium/chloridetransporters), member 2, solute carrierfamily 12, member 2177920888NM_012716c, esolute carrier family 16RIKEN cDNA 1110004H10 gene, RIKEN(monocarboxylic acidcDNA 1200003C15 gene, solute carriertransporters), member 1family 16 (monocarboxylic acidtransporters), member 1177920889NM_012716e, aa, bbsolute carrier family 16RIKEN cDNA 1110004H10 gene, RIKEN(monocarboxylic acidcDNA 1200003C15 gene, solute carriertransporters), member 1family 16 (monocarboxylic acidtransporters), member 1199623825NM_017299cc, ddsolute carrier family 19 (folatesolute carrier family 19 (folatetransporter), member 1,transporter), member 1, solute carriersolute carrier family 19family 19 (sodium/hydrogen exchanger),(sodium/hydrogenmember 1, solute carrier family 19exchanger), member 1(sodium/hydrogen exchanger), member3, solute carrier family 19 (thiaminetransporter), member 2, solute carrierfamily 19 (thiamine transproter), member2, solute carrier family 19, member 3255116248NM_138827y, zsolute carrier family 2Mus musculus, clone MGC: 8298(facilitated glucoseIMAGE: 3593581, mRNA, complete cds,transporter), member 1solute carrier family 2 (facilitated glucosetransporter), member 1255116249NM_138827j, ksolute carrier family 2Mus musculus, clone MGC: 8298(facilitated glucoseIMAGE: 3593581, mRNA, complete cds,transporter), member 1solute carrier family 2 (facilitated glucosetransporter), member 119731510NM_017224llsolute carrier family 22Homo sapiens, Similar to ust3, clone(organic anion transporter),MGC: 23972 IMAGE: 4714598, mRNA,member 6complete cds, Mus musculus, Similar tosolute carrier family 22 (organic aniontransporter), member 7, cloneMGC: 18877 IMAGE: 4236556, mRNA,complete cds, Rattus norvegicus mRNAfor organic anion transporter 5, completecds, expressed sequence AI648912,putative integral membrane transportUST1r, solute carrier family 22 (organicanion transporter), member 6, solutecarrier family 22 (organic cationtransporter)-like 2, ust3165518018D12771f, gsolute carrier family 25EST, Moderately similar to S03894(mitochondrial carrier;ADP, ATP carrier protein T3 [H. sapiens],adenine nucleotideEST, Weakly similar to A29132translocator), member 5ADP, ATP carrier protein T2 [H. sapiens],Homo sapiens, clone IMAGE: 5215220,mRNA, Mus musculus, Similar toCG4995 gene product, clone MGC: 7958IMAGE: 3584570, mRNA, complete cds,RIKEN cDNA 4933440H19 gene, folatetransporter/carrier, solute carrier family25 (mitochondrial carrier; adeninenucleotide translocator), member 5,solute carrier family 25 (mitochondrialcarrier; adenine nucleotide translocator),member 6231120743NM_031684a, x, z,solute carrier family 29ESTs, Weakly similar to solute carrierkk(nucleoside transporters),family 29 (nucleoside transporters),member 1member 1 [Rattus norvegicus][R. norvegicus], RIKEN cDNA4933435C21 gene, solute carrier family29 (nucleoside transporters), member 1205220734NM_019283j, k, t, u,solute carrier family 3solute carrier family 3 (activators ofv, jj, kk(activators of dibasic anddibasic and neutral amino acidneutral amino acid transport),transport), member 2member 2205220735NM_019283j, k, t, y,solute carrier family 3solute carrier family 3 (activators ofz, kk(activators of dibasic anddibasic and neutral amino acidneutral amino acid transport),transport), member 2member 2185218076NM_013030cc, ddsolute carrier family 34Rattus norvegicus mRNA for Na+/Pi-(sodium phosphate), member 1cotransporter type IIc, complete cds,Rattus norvegicus mRNA for NaPi-2alpha, complete cds, expressedsequence AI649385, solute carrier family34 (sodium phosphate), member 198516335AI045744b, u, vsolute carrier family 4 (anionESTs, Moderately similar to B3ATexchanger), member 1, soluteMOUSE BAND 3 ANION EXCHANGEcarrier family 4, anionPROTEIN [M. musculus], expressedexchanger, member 1sequence AI503023, solute carrier family(erythrocyte membrane4 (anion exchanger), member 1, soluteprotein band 3, Diego bloodcarrier family 4, anion exchanger,group)member 1 (erythrocyte membraneprotein band 3, Diego blood group)192024697NM_017048u, v, iisolute carrier family 4 (anionsolute carrier family 4 (anion exchanger),exchanger), member 2, solutemember 2, solute carrier family 4, anioncarrier family 4, anionexchanger, member 2 (erythrocyteexchanger, member 2membrane protein band 3-like 1)(erythrocyte membraneprotein band 3-like 1)196924859NM_017206h, lsolute carrier family 6solute carrier family 6 (neurotransmitter(neurotransmitter transporter,transporter, taurine), member 6taurine), member 619231876NM_017052w, xsorbitol dehydrogenase,ESTs, Highly similar to A54674 L-iditol 2-sorbitol dehydrogenase 1dehydrogenase [H. sapiens], sorbitoldehydrogenase, sorbitol dehydrogenase 1204923419NM_019257tsplicing factor, arginine/serine-ESTs, Weakly similar to SFR5 MOUSErich 5, splicing factor,SPLICING FACTOR,arginine/serine-rich 5 (SRp40,ARGININE/SERINE-RICH 5HRS)[M. musculus], Mus musculus, cloneMGC: 36924 IMAGE: 4945988, mRNA,complete cds, RIKEN cDNA1210001E11 gene, RIKEN cDNA6330415C05 gene, splicing factor,arginine/serine-rich 1 (splicing factor 2,alternate splicing factor), splicing factor,arginine/serine-rich 4, splicing factor,arginine/serine-rich 5, splicing factor,arginine/serine-rich 5 (SRp40, HRS)194816681NM_017136iisqualene epoxidaseHomo sapiens cDNA FLJ30795 fis, cloneFEBRA2001124, squalene epoxidase229414542NM_031596rsquamous cell carcinomaantigen recognised by T cells,squamous cell carcinomaantigen recognized by T-cells 1229414543NM_031596b, u, vsquamous cell carcinomaantigen recognised by T cells,squamous cell carcinomaantigen recognized by T-cells 186520924AI012832ii, llstanninRIKEN cDNA 2810407J07 gene, stannin249115707NM_058208dSTAT induced STAT inhibitor-ESTs, Weakly similar to cytokine2, cytokine inducible SH2-inducible SH2-containing protein CIS4containing protein 2[Mus musculus] [M. musculus], JAKbinding protein, RIKEN cDNA5830401B18 gene, STAT induced STATinhibitor-4, Socs-5, cytokine inducibleSH2-containing protein 2177121087NM_012661cc, ddsteroid sulfatase, steroidESTs, Highly similar to I37186sulfatase (microsomal),arylsulfatase D [H. sapiens], ESTs,arylsulfatase C, isozyme SWeakly similar to STS MOUSE STERYL-SULFATASE PRECURSOR[M. musculus], ESTs, Weakly similar toSTS_RAT STERYL-SULFATASEPRECURSOR (STEROID SULFATASE)(STERYL-SULFATESULFOHYDROLASE)(ARYLSULFATASE C) (ASC)[R. norvegicus], arylsulfatase E(chondrodysplasia punctata 1),arylsulfatase F, steroid sulfatase, steroidsulfatase (microsomal), arylsulfatase C,isozyme S123615393AI170663cc, ddsterol regulatory elementsterol regulatory element binding factorbinding transcription factor 21, sterol regulatory element bindingfactor 2, sterol regulatory elementbinding transcription factor 2169417508L08814iistructure specific recognitionESTs, Weakly similar to S35637 highprotein 1mobility group 1 protein homolog - rat(fragment) [R. norvegicus], Musmusculus, clone IMAGE: 4948318,mRNA, partial cds, Mus musculus, cloneIMAGE: 5355658, mRNA, structurespecific recognition protein 1242518175NM_053752aa, bbsuccinate-CoA ligase, GDP-forming, alpha subunit23364748NM_31834s, t, aa,sulfotransferase family 1A,Aryl sulfotransferase cytosolic, 1A,bbphenol-preferring, member 1,phenol-preferring, member 3, RIKENsulfotransferase family,cDNA 1110030E23 gene,cytosolic, 1A, phenol-sulfotransferase family 1A, phenol-preferring, member 1preferring, member 1, sulfotransferasefamily, cytosolic, 1A, phenol-preferring,member 1, sulfotransferase family,cytosolic, 1A, phenol-preferring, member 223364749NM_031834t, bbsulfotransferase family 1A,Aryl sulfotransferase cytosolic, 1A,phenol-preferring, member 1,phenol-preferring, member 3, RIKENsulfotransferase family,cDNA 1110030E23 gene,cytosolic, 1A, phenol-sulfotransferase family 1 A, phenol-preferring, member 1preferring, member 1, sulfotransferasefamily, cytosolic, 1A, phenol-preferring,member 1, sulfotransferase family,cytosolic, 1A, phenol-preferring, member 2192220875NM_017050hhsuperoxide dismutase 1,EST, Weakly similar to SODC MOUSEsoluble, superoxideSUPEROXIDE DISMUTASEdismutase 1, soluble[M. musculus], superoxide dismutase 1,(amyotrophic lateral sclerosissoluble (amyotrophic lateral sclerosis 11 (adult))(adult))192220876NM_017050rsuperoxide dismutase 1,EST, Weakly similar to SODC MOUSEsoluble, superoxideSUPEROXIDE DISMUTASEdismutase 1, soluble[M. musculus], superoxide dismutase 1,(amyotrophic lateral sclerosissoluble (amyotrophic lateral sclerosis 11 (adult))(adult))216418098NM_022947lsuppressor of K+ transportdefect 3, suppressor ofpotassium transport defect 321304601NM_022524l, msushi-repeat-containingESTs, Weakly similar to down-regulatedprotein, sushi-repeat-by v-src gene [Rattus norvegicus]containing protein, X[R. norvegicus], Homo sapiens mRNA;chromosomecDNA DKFZp586N2022 (from cloneDKFZp586N2022), RIKEN cDNA1110039C07 gene, RIKEN cDNA2610001E17 gene, sushi-repeat protein,sushi-repeat-containing protein, sushi-repeat-containing protein, Xchromosome83315917AI011498bSWI/SNF related, matrixSWI/SNF related, matrix associated,associated, actin dependentactin dependent regulator of chromatin,regulator of chromatin,subfamily d, member 2, SWI/SNFsubfamily d, member 2related, matrix associated, actindependent regulator of chromatin,subfamily d, member 3202720440NM_019166b, l, msynaptogyrin 1ESTs, Moderately similar to SNG1_RATSYNAPTOGYRIN 1 (P29)[R. norvegicus], synaptogyrin 1,synaptogyrin 3, synaptogyrin 423521171NM_032071y, zsynaptojanin 2EST, Weakly similar to JW0105synaptojanin 2 alpha protein - mouse[M. musculus], ESTs, Moderately similarto PW0049 synaptojanin 2 zeta protein -mouse (fragment) [M. musculus], ESTs,Weakly similar to JW0105 synaptojanin2 alpha protein - mouse [M. musculus],ESTs, Weakly similar to T42384 inositol-1,4,5-trisphosphate 5-phosphatase[M. musculus], Homo sapiens cDNA:FLJ23105 fis, clone LNG07677, inositolpolyphosphate 5-phosphatase,oculocerebrorenal syndrome of Lowe,phosphatidylinositol (4,5) bisphosphate 5phosphatase homolog;phosphatidylinositol polyphosphate 5-phosphatase type IV,phosphatidylinositol (4, 5) bisphosphate 5phosphatase, A, synaptojanin 2201520536NM_019122b, l, m, u, vsynaptotagmin 3,synaptotagmin III17699423NM_012649j, k, y, zsyndecan 4, syndecan 4syndecan 4, syndecan 4 (amphiglycan,(amphiglycan, ryudocan)ryudocan)22501265NM_031124u, vsyntaxin 3, syntaxin 3Asyntaxin 3, syntaxin 3A20287486NM_019169n, osynuclein, alpha, synuclein,synuclein, alpha, synuclein, alpha (nonalpha (non A4 component ofA4 component of amyloid precursor)amyloid precursor)196319031NM_017180p, qT-cell death associated gene,ESTs, Weakly similar to S58222 PQ-richpleckstrin homology-likeprotein [H. sapiens], T-cell deathdomain, family A, member 1associated gene, pleckstrin homology-like domain, family A, member 1,pleckstrin homology-like domain, familyA, member 3, tumor suppressingsubtransferable candidate 3, tumor-suppressing subchromosomaltransferable fragment 3262025593U26310ggtensin229121715NM_031578aatestis specific protein kinaseRIKEN cDNA 4833428C18 gene, RIKEN1, testis-specific kinase 1cDNA 4930584N22 gene, hypotheticalprotein BC007901, testis specific proteinkinase 1, testis-specific kinase 1, testis-specific kinase 2229924234NM_031614r, y, z, jj,thioredoxin reductase 1thioredoxin reductase 1, thioredoxinkkreductase 2229924235NM_031614y, z, kkthioredoxin reductase 1thioredoxin reductase 1, thioredoxinreductase 2214021076NM_022584e, w, xthioredoxin reductase 2thioredoxin reductase 245012031AA893860y, zthreonyl-tRNA synthetasethreonyl-tRNA synthetase181516871NM_012887y, llthymopoietinESTs, Highly similar to THPA_HUMANTHYMOPOIETIN ALPHA [H. sapiens],RIKEN cDNA 5630400D24 gene,thymopoietin207720816NM_021261cthymosin, beta 10185511113NM_013046l, k, p, q,thyrotropin releasingthyrotropin releasing hormone,u, v, gghormone, thyrotropin-thyrotropin-releasing hormonereleasing hormone185511114NM_013046k, n, o, y,thyrotropin releasingthyrotropin releasing hormone,z, kkhormone, thyrotropin-thyrotropin-releasing hormonereleasing hormone2092243NM_021989h, l, n, o,tissue inhibitor ofHomo sapiens mRNA; cDNAllmetalloproteinase 2DKFZp761A0617 (from cloneDKFZp761A0617), tissue inhibitor ofmetalloproteinase 222917236AA858903s, t, ggtissue inhibitor oftissue inhibitor of metalloproteinase 3,metalloproteinase 3, tissuetissue inhibitor of metalloproteinase 3inhibitor of metalloproteinase(Sorsby fundus dystrophy,3 (Sorsby fundus dystrophy,pseudoinflammatory)pseudoinflammatory)51217231AA924107iitissue inhibitor oftissue inhibitor of metalloproteinase 3,metalloproteinase 3, tissuetissue inhibitor of metalloproteinase 3inhibitor of metalloproteinase(Sorsby fundus dystrophy,3 (Sorsby fundus dystrophy,pseudoinflammatory)pseudoinflammatory)69717232AA965161lltissue inhibitor oftissue inhibitor of metalloproteinase 3,metalloproteinase 3, tissuetissue inhibitor of metalloproteinase 3inhibitor of metalloproteinase(Sorsby fundus dystrophy,3 (Sorsby fundus dystrophy,pseudoinflammatory)pseudoinflammatory)47623778AA899854ctopoisomerase (DNA) IIESTs, Moderately similar to A40493alpha, topoisomerase (DNA)DNA topoisomerase [H. sapiens], ESTs,II alpha (170 kD)Weakly similar to topoisomerase (DNA)II alpha [Rattus norvegicus][R. norvegicus], topoisomerase (DNA) IIalpha, topoisomerase (DNA) II beta209423780NM_022183jj, kktopoisomerase (DNA) IIESTs, Moderately similar to A40493alpha, topoisomerase (DNA)DNA topoisomerase [H. sapiens], ESTs,II alpha (170 kD)Weakly similar to topoisomerase (DNA)II alpha [Rattus norvegicus][R. norvegicus], topoisomerase (DNA) IIalpha, topoisomerase (DNA) II beta2378622NM_053369a, j, ktranscription factor 4EST, Highly similar to TRANSCRIPTIONFACTOR 4 [M. musculus], transcriptionfactor 42378623NM_053369r, hhtranscription factor 4EST, Highly similar to TRANSCRIPTIONFACTOR 4 [M. musculus], transcriptionfactor 4207918729NM_021578rtransforming growth factor,beta 1, transforming growthfactor, beta 1 (Camurati-Engelmann disease)1723457M60666aatropomyosin 1 (alpha),Homo sapiens cDNA FLJ30635 fis, clonetropomyosin 1, alphaCTONG2002520, expressed sequenceAI854628, expressed sequence C76867,tropomyosin 4, tuftelin 12018455NM_019131b, u, vtropomyosin 1 (alpha),Homo sapiens cDNA FLJ30635 fis, clonetropomyosin 1, alphaCTONG2002520, expressed sequenceAI854628, expressed sequence C76867,tropomyosin 4, tuftelin 12018461NM_019131b, l, mtropomyosin 1 (alpha),Homo sapiens cDNA FLJ30635 fis, clonetropomyosin 1, alphaCTONG2002520, expressed sequenceAI854628, expressed sequence C76867,tropomyosin 4, tuftelin 1177324854NM_012676aa, bbtroponin T2, cardiacEST, Weakly similar to TRT2 MOUSETROPONIN T, CARDIAC MUSCLEISOFORMS [M. musculus], hypotheticalprotein FLJ10498181124617NM_012870iitumor necrosis factor receptortumor necrosis factor receptorsuperfamily, member 11bsuperfamily, member 11a, tumor(osteoprotegerin)necrosis factor receptor superfamily,member 11a, activator of NFKB, tumornecrosis factor receptor superfamily,member 11b (osteoprotegerin), tumornecrosis factor receptor superfamily,member 21, tumor necrosis factorreceptor superfamily, member 5, tumornecrosis factor receptor superfamily,member 6b, decoy193523665NM_017092u, vTYRO3 protein tyrosineAXL receptor tyrosine kinase, TYRO3kinase, TYRO3 proteinprotein tyrosine kinase, TYRO3 proteintyrosine kinase 3tyrosine kinase 3229519341NM_031603h, ltyrosine 3-ESTs, Highly similar to I38947 14-3-3monooxygenase/tryptophan 5-protein epsilon isoform [H. sapiens],monooxygenase activationtyrosine 3-monooxygenase/tryptophan 5-protein, epsilon polypeptidemonooxygenase activation protein,epsilon polypeptide5543817AA926328p, qtyrosine 3-ESTs, Highly similar to A Chain A, 14-3-monooxygenase/tryptophan 5-3 ZetaPHOSPHOPEPTIDE COMPLEXmonooxygenase activation[H. sapiens], tyrosine 3-protein, zeta polypeptidemonooxygenase/tryptophan 5-monooxygenase activation protein, zetapolypeptide184625279NM_013011p, qtyrosine 3-ESTs, Highly similar to A Chain A, 14-3-monooxygenase/tryptophan 5-3 ZetaPHOSPHOPEPTIDE COMPLEXmonooxygenase activation[H. sapiens], tyrosine 3-protein, zeta polypeptidemonooxygenase/tryptophan 5-monooxygenase activation protein, zetapolypeptide18463404NM_013011p, qtyrosine 3-ESTs, Highly similar to A Chain A, 14-3-monooxygenase/tryptophan 5-3 ZetaPHOSPHOPEPTIDE COMPLEXmonooxygenase activation[H. sapiens], tyrosine 3-protein, zeta polypeptidemonooxygenase/tryptophan 5-monooxygenase activation protein, zetapolypeptide171215049M24542aa, bbubiquinol-cytochrome cEST, Weakly similar to UCRI_HUMANreductase, Rieske iron-sulfurUBIQUINOL-CYTOCHROME Cpolypeptide 1REDUCTASE IRON-SULFUR SUBUNIT,MITOCHONDRIAL PRECURSOR[H. sapiens], ESTs, Moderately similar toUCRI_HUMAN UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT, MITOCHONDRIALPRECURSOR [H. sapiens], RIKEN cDNA4430402G14 gene, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1247715125NM_057105jj, kk, llUDP glycosyltransferase 1UDP glycosyltransferase 1 family,family, polypeptide A6polypeptide A6, UDP glycosyltransferase1 family, polypeptide A813323828AA817823iiUDP-Gal: betaGlcNAc betaMus musculus, Similar to xylosylprotein1,4-galactosyltransferase,beta1, 4-galactosyltransferase,polypeptide 2polypeptide 7 (galactosyltransferase I),clone MGC: 28643 IMAGE: 4224150,mRNA, complete cds, UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1,UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 224267927NM_053765dUDP-N-acetylglucosamine-2-UDP-N-acetylglucosamine-2-epimerase/N-epimerase/N-acetylmannosamine kinaseacetylmannosamine kinase2023278NM_019150aa, bburocortinurocortin268819279Y00350a, aa,uroporphyrinogenbb, jj, kkdecarboxylase12156888AI169615s, tVAMP (vesicle-associatedVAMP (vesicle-associated membranemembrane protein)-protein)-associated protein A (33 kD),associated protein A (33 kD),vesicle-associated membrane protein,vesicle-associated membraneassociated protein A (33 kDa)protein, associated protein A(33 kDa)143916203AI229196w, x, cc,vesicle-associated membranevesicle-associated membrane protein 1,ddprotein 1, vesicle-associatedvesicle-associated membrane protein 2,membrane protein 1vesicle-associated membrane protein 4(synaptobrevin 1), vesicle-associated membrane protein2, vesicle-associatedmembrane protein 2(synaptobrevin 2)177216197NM_012663j, kvesicle-associated membraneprotein 2, vesicle-associatedmembrane protein 2(synaptobrevin 2)247223250NM_057097f, gvesicle-associated membraneESTs, Weakly similar to vesicle-protein 3, vesicle-associatedassociated membrane protein 3 [Rattusmembrane protein 3norvegicus] [R. norvegicus], vesicle-(cellubrevin)associated membrane protein 3, vesicle-associated membrane protein 3(cellubrevin), vesicle-associatedmembrane protein 4202624362NM_019156jj, kkvitronectin, vitronectin (serumspreading factor,somatomedin B, complementS-protein)195621975NM_017154d, e, j, k,xanthene dehydrogenase,n, o, y, z,xanthine dehydrogenasekk196020919NM_017172azinc finger protein 36, C3HESTs, Weakly similar to S10471 cMG1type-like 1protein - rat [R. norvegicus], zinc fingerprotein 36, C3H type-like 1, zinc fingerprotein 36, C3H type-like 2251125730NM_133290j, k, p, qzinc finger protein 36, zinczinc finger protein 36, zinc finger proteinfinger protein 36, C3H type,36, C3H type, homolog (mouse)homolog (mouse)25418692NM_134387hh2,4-dienoyl CoA reductase 1,mitochondrial, 2,4-dienoyl CoAreductase 2, peroxisomal, 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal,RIKEN cDNA 1810027P18 gene,putative peroxisomal 2,4-dienoyl-CoAreductase17719451AA819788c28 kD interferon responsive protein,RIKEN cDNA 5830458K16 gene164623219AJ000347n, o3′(2′), 5′-bisphosphate nucleotidase 1,ESTs, Moderately similar to INPPMOUSE INOSITOL POLYPHOSPHATE1-PHOSPHATASE [M. musculus],bisphosphate 3′-nucleotidase 1,hypothetical protein FLJ20421, inositolpolyphosphate-1-phosphatase171515580M33648y, z3-hydroxy-3-methylglutaryl-Coenzyme Asynthase 2,3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)246517739NM_053995g3-hydroxybutyrate dehydrogenase(heart, mitochondrial), ESTs, Weaklysimilar to BDH_RAT D-beta-hydroxybutyrate dehydrogenase,mitochondrial precursor (BDH) (3-hydroxybutyrate dehydrogenase)[R. norvegicus], RIKEN cDNA0610039E24 gene, RIKEN cDNA2310032J20 gene, retinoldehydrogenase 7, retinol dehydrogenasetype 588921950AI013861a, h, l3-hydroxyisobutyrate dehydrogenase,ESTs, Highly similar to D3HI_HUMAN 3-HYDROXYISOBUTYRATEDEHYDROGENASE, MITOCHONDRIALPRECURSOR (HIBADH) [H. sapiens],RIKEN cDNA 3930401K13 gene20601238NM_019333gg6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4,ESTs, Moderately similar to F26LMOUSE 6PF-2-K/FRU-2,6-P2ASELIVER ISOZYME [M. musculus]207613486NM_020306aa, bba disintegrin and metalloproteinasedomain 17, a disintegrin andmetalloproteinase domain 17 (tumornecrosis factor, alpha, convertingenzyme)232320724NM_031753dactivated leucocyte cell adhesionmolecule, activated leukocyte celladhesion molecule2198938NM_024486u, vactivin A receptor, type 1, activin Areceptor, type I208319661NM_021686nactivin receptor interacting protein 1,connector enhancer of KSR2, expressedsequence AA407180, phosphoinositide-binding protein PIP3-E4724636AA899491eadaptor-related protein complex 1, mu 1subunit25321271NM_133593a, ee, ff,adaptor-related protein complex 3, mu 1jj, kksubunit, adaptor-related protein complexAP-3, mu 1 subunit231724081NM_031708eadhesion regulating molecule 1144515212AI229753p, q, t, y,ADP-ribosylation factor 1, ADP-z, ee, ffribosylation factor 2, ARF protein21781742NM_024150p, q, y,ADP-ribosylation factor 1, ADP-ee, ffribosylation factor 2, ARF protein21274145NM_022518jj, kkADP-ribosylation factor 1, ADP-ribosylation-like 6, ESTs, Weakly similarto ADP-RIBOSYLATION FACTOR 1[M. musculus], expressed sequenceT2553421274151NM_022518b, l, mADP-ribosylation factor 1, ADP-ribosylation-like 6, ESTs, Weakly similarto ADP-RIBOSYLATION FACTOR 1[M. musculus], expressed sequenceT25534217917517NM_024151fADP-ribosylation factor 4218021696NM_024152y, zADP-ribosylation factor 6, ESTs, Weaklysimilar to ARF6_HUMAN ADP-RIBOSYLATION FACTOR 6[M. musculus], ESTs, Weakly similar toARF6_HUMAN ADP-ribosylation factor 6[R. norvegicus], RIKEN cDNA1110033P22 gene, RIKEN cDNA2310075M17 gene, RIKEN cDNA9130014L17 gene, SAR1 protein,SAR1a gene homolog (S. cerevisiae),hypothetical protein FLJ2259555220327AA926265cc, ddADP-ribosylation factor-like 5, ADP-ribosylation-like 6, expressed sequenceT25534, hypothetical proteinDKFZp434L1123 similar to mouse Arl62480727NM_057123s, tAFG3 ATPase family gene 3-like 1(yeast), BCS1-like (yeast), EST, Weaklysimilar to PRS4_HUMAN 26S proteaseregulatory subunit 4 (P26S4)[M. musculus], ESTs, Highly similar toPRS4_HUMAN 26S protease regulatorysubunit 4 (P26S4) [H. sapiens], Homosapiens cDNA FLJ31926 fis, cloneNT2RP7005502, moderately similar toHomo sapiens mRNA for paraplegin-likeprotein, protease (prosome, macropain)26S subunit, ATPase 1, proteasome(prosome, macropain) 26S subunit,ATPase, 124182063NM_053682eAFG3 ATPase family gene 3-like 2(yeast), AFG3 (ATPase family gene 3)-like 1 (yeast), Mus musculus, cloneIMAGE: 5040761, mRNA, partial cds,YME1-like 1 (S. cerevisiae), spasticparaplegia 7, paraplegin (pure andcomplicated autosomal recessive)14033094AI79700b, l, mAgrin, ESTs, Weakly similar to A38096perlecan precursor [H. sapiens], ESTs,Weakly similar to BASEMENTMEMBRANE-SPECIFIC HEPARANSULFATE PROTEOGLYCAN COREPROTEIN PRECURSOR [M. musculus],ESTs, Weakly similar to PGBM_HUMANBASEMENT MEMBRANE-SPECIFICHEPARAN SULFATE PROTEOGLYCANCORE PROTEIN PRECURSOR[H. sapiens], Mus musculus, cloneIMAGE: 3494258, mRNA, partial cds,heparan sulfate proteoglycan 2(perlecan), perlecan (heparan sulfateproteoglycan 2), serine proteaseinhibitor, Kazal type, 5, sialoadhesin,transmembrane protein with EGF-likeand two follistatin-like domains 128016074AA874874p, qalcohol dehydrogenase 5, alcoholdehydrogenase 5 (class III), chipolypeptide234324644NM_031972cc, ddaldehyde dehydrogenase 3 family,member B1, aldehyde dehydrogenase 3family, member B2, aldehydedehydrogenase 3 family, memberA1,aldehyde dehydrogenase family 3,subfamily A14854725AA900290t, y, z,Alpha-2-macroglobulin, CCR4 carbonee, ffcatabolite repression 4-like (S.cerevisiae), ESTs, Weakly similar toA2MG MOUSE ALPHA-2-MACROGLOBULIN PRECURSOR[M. musculus], Homo sapiens, cloneMGC: 1119 IMAGE: 2959975, mRNA,complete cds, Mus musculus, cloneMGC: 29037 IMAGE: 3598248, mRNA,complete cds, Mus musculus, cloneMGC: 29167 IMAGE: 5052974, mRNA,complete cds, alpha-2-macroglobulin,carbon catabolite repression 4 homolog(S. cerevisiae), pregnancy-zone protein21718269NM_023103b, l, malpha-2-macroglobulin, murinoglobulin 1,murinoglobulin 2, murinoglobulin,pseudogene 1187616649NM_013132c, ggannexin A522215260AA858518f, gAPC11 anaphase promoting complexsubunit 11 homolog (yeast), ESTs,Highly similar to T51146 ring-box protein1 [H. sapiens], ESTs, Weakly similar toT51146 ring-box protein 1 [H. sapiens],ring finger protein 7, ring-box 168718830AA964496a, zARP2 actin-related protein 2 homolog(yeast), ARP3 actin-related protein 3homolog (yeast), EST, Weakly similar toACTB_HUMAN Actin, cytoplasmic 1(Beta-actin) [R. norvegicus], ESTs, Highlysimilar to ACTB_HUMAN ACTIN,CYTOPLASMIC 1 [M. musculus], ESTs,Weakly similar to A29861 actin gamma[H. sapiens], ESTs, Weakly similar toACTB_HUMAN ACTIN, CYTOPLASMIC1 [M. musculus], Homo sapiens cDNAFLJ31247 fis, clone KIDNE2005296,weakly similar to ACTIN,CYTOPLASMIC 1, Homo sapiens cDNAFLJ32120 fis, clone PEBLM1000068,highly similar to ACTIN, CYTOPLASMICTYPE 5, Homo sapiens mRNA; cDNADKFZp434B2115 (from cloneDKFZp434B2115), RIKEN cDNA1700052K15 gene, actin, beta, actin,beta, cytoplasmic, calcitonin gene-related peptide-receptor componentprotein, expressed sequence AV259599113718831AI104357bbARP2 actin-related protein 2 homolog(yeast), ARP3 actin-related protein 3homolog (yeast), EST, Weakly similar toACTB_HUMAN Actin, cytoplasmic 1(Beta-actin) [R. norvegicus], ESTs, Highlysimilar to ACTB_HUMAN ACTIN,CYTOPLASMIC 1 [M. musculus], ESTs,Weakly similar to A29861 actin gamma[H. sapiens], ESTs, Weakly similar toACTB_HUMAN ACTIN, CYTOPLASMIC1 [M. musculus], Homo sapiens cDNAFLJ31247 fis, clone KIDNE2005296,weakly similar to ACTIN,CYTOPLASMIC 1, Homo sapiens cDNAFLJ32120 fis, clone PEBLM1000068,highly similar to ACTIN, CYTOPLASMICTYPE 5, Homo sapiens mRNA; cDNADKFZp434B2115 (from cloneDKFZp434B2115), RIKEN cDNA1700052K15 gene, actin, beta, actin,beta, cytoplasmic, calcitonin gene-related peptide-receptor componentprotein, expressed sequence AV2595992305867AA858953kkasparaginyl-tRNA synthetase,hypothetical protein FLJ23441138315091AI178740cc, ddAT2 receptor-interacting protein 1, Homosapiens cDNA FLJ32157 fis, clonePLACE6000205, moderately similar toTRANSCRIPTIONAL REPRESSORPROTEIN YY1, YY1 transcription factor25597395NM_138883rATP synthase, H+ transporting,mitochondrial F1 complex, O subunit,ATP synthase, H+ transporting,mitochondrial F1 complex, O subunit(oligomycin sensitivity conferringprotein), EST, Weakly similar toATPO_HUMAN ATP SYNTHASEOLIGOMYCIN SENSITIVITYCONFERRAL PROTEIN PRECURSOR,MITOCHONDRIAL [H. sapiens], ESTs,Highly similar to ATPO_HUMAN ATPSYNTHASE OLIGOMYCINSENSITIVITY CONFERRAL PROTEINPRECURSOR, MITOCHONDRIAL[H. sapiens], ESTs, Moderately similar toATPO_HUMAN ATP SYNTHASEOLIGOMYCIN SENSITIVITYCONFERRAL PROTEIN PRECURSOR,MITOCHONDRIAL [H. sapiens]250920738NM_131907cATPase, Ca++ transporting, type 2C,member 1, ATPase, Ca++ transporting,ubiquitous, Homo sapiens cDNA:FLJ21771 fis, clone COLF7779, Homosapiens mRNA; cDNA DKFZp434L231(from clone DKFZp434L231), KIAA0703gene product, putative secretorypathway Ca-ATPase SPCA2244820939NM_053884ggATPase, H+ transporting, lysosomal14 kD, V1 subunit F120922661AI169265ggATPase, H+ transporting, lysosomalinteracting protein 1, EST, Weaklysimilar to I54197 hypothetical protein[H. sapiens], ESTs, Weakly similar toVAS1_RAT Vacuolar ATP synthasesubunit S1 precursor (V-ATPase S1subunit) (V-ATPase S1 accessoryprotein) (V-ATPase Ac45 subunit) (C7-1protein) [R. norvegicus], Homo sapienscDNA FLJ12563 fis, cloneNT2RM4000820, weakly similar toVACUOLAR ATP SYNTHASE SUBUNITAC45 PRECURSOR (EC 3.6.1.34),expressed sequence AW108110232716178NM_031785fATPase, H+ transporting, lysosomalinteracting protein 1, EST, Weaklysimilar to I54197 hypothetical protein[H. sapiens], ESTs, Weakly similar toVAS1_RAT Vacuolar ATP synthasesubunit S1 precursor (V-ATPase S1subunit) (V-ATPase S1 accessoryprotein) (V-ATPase Ac45 subunit) (C7-1protein) [R. norvegicus], Homo sapienscDNA FLJ12563 fis, cloneNT2RM4000820, weakly similar toVACUOLAR ATP SYNTHASE SUBUNITAC45 PRECURSOR (EC 3.6.1.34),expressed sequence AW108110229620840NM_031604cc, ddATPase, H+ transporting, lysosomal V0subunit A isoform 4, ATPase, H+transporting, lysosomal V0 subunit aisoform 1, ATPase, H+ transporting,lysosomal V0 subunit a isoform 2,ATPase, H+ transporting, lysosomal V0subunit a isoform 4, EST, Weakly similarto B38656 vacuolar proton pump 116 Kchain - rat [R. norvegicus], ESTs,Moderately similar to B38656 vacuolarproton pump 116 K chain - rat[R. norvegicus]187123709NM_013113f, gATPase, Na+/K+ transporting, beta 1polypeptide187123710NM_013113hhATPase, Na+/K+ transporting, beta 1polypeptide15603650AI235738rATP-binding cassette, sub-family C(CFTR/MRP), member 4, ATP-bindingcassette, sub-family C (CFTR/MRP),member 9, ESTs, Weakly similar to ATP-binding cassette, sub-family C, member9, isoform c; sulfonylurea-binding protein2; sulfonylurea receptor 2 [Musmusculus] [M. musculus], Homo sapienscDNA FLJ31957 fis, cloneNT2RP7007381, highly similar toSulfonylurea receptor 2A, Mus musculusadult male pituitary gland cDNA, RIKENfull-length enriched library,clone: 5330439B14: ATP-bindingcassette, sub-family C (CFTR/MRP),member 9, full insert sequence121724146AI169668iiATP-binding cassette, sub-family F(GCN20), member 224820582AA859688w, hhAU RNA binding protein/enoyl-Coenzyme A hydratase, AU RNA bindingprotein/enoyl-coenzyme A hydratase,ESTs, Weakly similar to I37195 AU-specific RNA-binding protein/enoyl-CoAhydratase homolog [H. sapiens], Musmusculus, Similar to 3-hydroxyisobutyryl-Coenzyme A hydrolase, cloneMGC: 31364 IMAGE: 4238681, mRNA,complete cds, RIKEN cDNA1300017C12 gene, uncharacterizedhypothalamus protein HCDASE79822545AI009747aB-cell translocation gene 1, anti-proliferative, ESTs, Highly similar toTOB1_HUMAN TOB1 PROTEIN[H. sapiens], transducer of ERBB2, 1,transducer of ERBB2, 2, transducer ofErbB-2.1205523679NM_019290p, qB-cell translocation gene 3, BTG family,member 3250023033NM_080888rBCL2/adenovirus E1B 19 kDa-interactingprotein 3-like, BCL2/adenovirus E1B19 kD interacting protein 3-like215317757NM_022698cc, ddBCL2-antagonist of cell death, Bcl-associated death promoter78121632AI009167a, y, z,BCL2-associated athanogene 2ee, ff149315171AI231792ee, ffBCL2-associated athanogene 3, BCL2-associated athanogene 5, Bcl2-associated athanogene 3, RIKEN cDNA1700081D05 gene55822677AA942718s, t, kkBCL2-related ovarian killer, Bcl2-like66023957AA957123cbrain expressed, X-linked 1, hypotheticalprotein FLJ10097146622387AI230753f, gbrain protein I341211997AA892828f, h, lbranched chain ketoacid dehydrogenaseE1, beta polypeptide, pyruvatedehydrogenase (lipoamide) beta13135876AI176117hhbranched chain ketoacid dehydrogenaseE1, beta polypeptide, pyruvatedehydrogenase (lipoamide) beta220921801NM_030987cc, dd, iiBUB3 budding uninhibited bybenzimidazoles 3 homolog (yeast),ESTs, Weakly similar to guaninenucleotide-binding protein, beta-1#subunit [Rattus norvegicus][R. norvegicus], Mus musculus, cloneMGC: 7934 IMAGE: 3583848, mRNA,complete cds, budding uninhibited bybenzimidazoles 3 homolog (S.cerevisiae), guanine nucleotide bindingprotein, beta 1, neural precursor cellexpressed, developmentally down-regulated gene 1220921805NM_030987cc, ddBUB3 budding uninhibited bybenzimidazoles 3 homolog (yeast),ESTs, Weakly similar to guaninenucleotide-binding protein, beta-1#subunit [Rattus norvegicus][R. norvegicus], Mus musculus, cloneMGC: 7934 IMAGE: 3583848, mRNA,complete cds, budding uninhibited bybenzimidazoles 3 homolog (S.cerevisiae), guanine nucleotide bindingprotein, beta 1, neural precursor cellexpressed, developmentally down-regulated gene 16982582AA965164ggCAC-1, RIKEN cDNA 1810017F10 gene,RIKEN cDNA 2010001C09 gene259415711NM_153629pcalcium binding protein, 140 kDa, heatshock 70 kDa protein 4, heat shock70 kD protein 4, heat shock protein(hsp110 family), osmotic stress protein94 kDa, oxygen regulated protein(150 kD)43511935AA893328ggcalmegin, calnexin6717875AA799755cc, ddCarboxypeptidase E, ESTs, Weaklysimilar to carboxypeptidase E [Rattusnorvegicus] [R. norvegicus],carboxypeptidase E, carboxypeptidase X1 (M14 family), expressed sequenceAA589379, expressed sequenceAA986902179118066NM_012762aa, bbCARD only protein, ESTs, Moderatelysimilar to A57511 interleukin-1 betaconverting enzyme [H. sapiens], ESTs,Weakly similar to A56084 interleukin-1beta converting enzyme beta isozyme[H. sapiens], Homo sapiens mRNA;cDNA DKFZp586A181 (from cloneDKFZp586A181); partial cds, ICEBERGcaspase-1 inhibitor, caspase 1, caspase1, apoptosis-related cysteine protease(interleukin 1, beta, convertase)179118068NM_012762eCARD only protein, ESTs, Moderatelysimilar to A57511 interleukin-1 betaconverting enzyme [H. sapiens], ESTs,Weakly similar to A56084 interleukin-1beta converting enzyme beta isozyme[H. sapiens], Homo sapiens mRNA;cDNA DKFZp586A181 (from cloneDKFZp586A181); partial cds, ICEBERGcaspase-1 inhibitor, caspase 1, caspase1, apoptosis-related cysteine protease(interleukin 1, beta, convertase)146724270AI230758n, ocargo selection protein (mannose 6phosphate receptor binding protein)20021894NM_017320b, l, m,cathepsin Skk134316124AI176963p, q, r,Cbp/p300-interacting transactivator withbb, ee,Glu/Asp-rich carboxy-terminal domain 1,ff, jj, kkCbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 1,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 2,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 4241916122NM_053698p, q, ee,Cbp/p300-interacting transactivator withffGlu/Asp-rich carboxy-terminal domain 1,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 1,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 2,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 4241916123NM_053698d, p, q, jj,Cbp/p300-interacting transactivator withkkGlu/Asp-rich carboxy-terminal domain 1,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 1,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 2,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 44944790AA900875ee, ffCbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 1,Cbp/p300-interacting transactivator, withGlu/Asp-rich carboxy-terminal domain, 418678899NM_013087d, fCD 81 antigen, CD81 antigen (target ofantiproliferative antibody 1), ESTs,Weakly similar to CD81 ANTIGEN[M. musculus], ESTs, Weakly similar toCD81_RAT CD81 antigen (26 kDa cellsurface protein TAPA-1) (Target of theantiproliferative antibody 1)[R. norvegicus]208619710NM_021744a, j, k, q,CD14 antigenhh, kk21294412NM_022523l, mCD151 antigen, EST AI426782, ESTs,Moderately similar to C151 MOUSEPLATELET-ENDOTHELIALTETRASPAN ANTIGEN 3 [M. musculus],RIKEN cDNA 1110014F12 gene, RIKENcDNA 2210021G21 gene, RIKEN cDNA2610042G18 gene, RIKEN cDNA2700063A19 gene, transmembrane 4superfamily member 619321523NM_017079h, l, n, o,CD1B antigen, b polypeptide, CD1Dw, xantigen, d polypeptide, CD1E antigen, epolypeptide, CD1d1 antigen, CD1d2antigen, expressed sequence AI747460256717854NM_139103iiCD2 antigen family, member 10, CD48antigen, CD48 antigen (B-cell membraneprotein), CD84 antigen, ESTs, Weaklysimilar to CD48_RAT MRC OX-45surface antigen precursor (BCM1surface antigen) (BLAST-1) (CD48)[R. norvegicus], RIKEN cDNA5830408F06 gene, expressed sequenceAI44923466624040AA957422n, o, w, xCD3 antigen, zeta polypeptide, CD3Zantigen, zeta polypeptide (TiT3complex), Fc fragment of IgE, highaffinity I, receptor for; gammapolypeptide, Fc receptor, IgE, highaffinity I, gamma polypeptide, Homosapiens Similar to Fc fragment of IgE,high affinity I, receptor for; gammapolypeptide, clone MGC: 22620IMAGE: 4704425, mRNA, complete cds,T-cell receptor CD3, subunit zeta39324873AA892498jj, kkCD63 antigen (melanoma 1 antigen),Cd63 antigen, EST, Weakly similar toCD63 MOUSE CD63 ANTIGEN[M. musculus], expressed sequenceC75951, tetraspan 3, transmembrane 4superfamily member 8211122499NM_022393a, p, q,CD72 antigen, Mus musculus straincc, dd,BALB/c dectin-2 gamma isoform mRNA,ee, ff, jj,complete cds, alternatively spliced, NKkkreceptor Ly-49Q, asialoglycoproteinreceptor 1, macrophage galactose N-acetyl-galactosamine specific lectin252320890NM_133526iiCD9 antigen, CD9 antigen (p24), ESTs,Highly similar to 2103288A CD9 protein[Rattus norvegicus] [R. norvegicus], Musmusculus, clone MGC: 38363IMAGE: 5344986, mRNA, complete cds,RIKEN cDNA 6330415F13 gene,transmembrane 4 superfamily member3, uroplakin 1A30415372AA875205y, zCDA02 protein, ESTs, Weakly similar toIF39_HUMAN EUKARYOTICTRANSLATION INITIATION FACTOR 3SUBUNIT 9 [H. sapiens]168515374H34186j, kCDA02 protein, ESTs, Weakly similar toIF39_HUMAN EUKARYOTICTRANSLATION INITIATION FACTOR 3SUBUNIT 9 [H. sapiens]238714904NM_053492s, tCDw92 antigen, ESTs, Weakly similar toCTL2 gene [Homo sapiens] [H. sapiens],ESTs, Weakly similar to transporter-likeprotein [Rattus norvegicus][R. norvegicus], Homo sapiens, cloneMGC: 34032 IMAGE: 4828797, mRNA,complete cds, Mus musculus, Similar totransporter-like protein, clone MGC: 7894IMAGE: 3582543, mRNA, complete cds,RIKEN cDNA 1110028E10 gene, RIKENcDNA 2210409B01 gene, chromosome 6open reading frame 29, expressedsequence AW54736525301827NM_133572r, u, vcell division cycle 25 homolog B (S.cerevisiae), cell division cycle 25homolog C (S. cerevisiae), cell divisioncycle 25B, cell division cycle 25C25301830NM_133572vcell division cycle 25 homolog B (S.cerevisiae), cell division cycle 25homolog C (S. cerevisiae), cell divisioncycle 25B, cell division cycle 25C25301831NM_133572vcell division cycle 25 homolog B (S.cerevisiae), cell division cycle 25homolog C (S. cerevisiae), cell divisioncycle 25B, cell division cycle 25C41622871AA892859ggcerebral cell adhesion molecule3323294AA799472bCGI-116 protein44319505AA893634r, iiCGI-120 protein, COPZ2 for nonclathrincoat protein zeta-COP, coatomer proteincomplex, subunit zeta 115883368AI237331cCGI-143 protein102918AI070195w, xCGI-20 protein15203100AI232741hhCGI-51 protein, EST, Weakly similar toCG51_HUMAN PROTEIN CGI-51[H. sapiens]64714327AA956111h, lCGI-69 protein, EST, Moderately similarto T43493 hypothetical proteinDKFZp434C119.1 [H. sapiens],mitochondrial carrier family protein2565734NM_139094ggCGI-74-like SR-rich, DNA segment, Chr17, human D6S45, EST, Weakly similarto SRA4_HUMAN CTD-BINDING SR-LIKE PROTEIN RA4 [H. sapiens], ESTs,Highly similar to T31420 C-terminaldomain-binding protein rA8 - rat[R. norvegicus], ESTs, Moderately similarto RD PROTEIN [M. musculus], ESTs,Weakly similar to RD PROTEIN[M. musculus], ESTs, Weakly similar toT31420 C-terminal domain-bindingprotein rA8 - rat [R. norvegicus],KIAA1116 protein, expressed sequenceAI447644, expressed sequenceAI448652, hypothetical proteinFLJ10290, pre-mRNA splicing SRprotein rA4162917215AI639268h, l, n, o,CGI-86 protein, DKFZP566O084 protein,jj, kkESTs, Weakly similar to T17307hypothetical protein DKFZp566O084.1[H. sapiens], hypothetical proteinMGC4172, retinal short chaindehydrogenase reductase29416319AA875047echaperonin containing TCP1, subunit 6A(zeta 1), chaperonin subunit 6a (zeta)60722615AA945643kkchitinase 3-like 1, chitinase 3-like 1(cartilage glycoprotein-39)22161024NM_031016s, u, vcholinergic receptor, muscarinic 222161025NM_031016u, vcholinergic receptor, muscarinic 28418881AA799992c, h, l, n,chromosome 11 open reading frame 17,o, w, xpredicted gene ICRFP703B1614Q5.68418883AA799992c, n, o,chromosome 11 open reading frame 17,kkpredicted gene ICRFP703B1614Q5.687823444AI013448dchromosome 20 open reading frame 30186117181NM_013073ggchromosome 20 open reading frame 36,protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase 1186121830NM_013073aa, bbchromosome 20 open reading frame 36,protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase 17721000AA799816h, lchromosome 7 open reading frame 2,lipocalin-interacting membrane receptor2602951S69206iichymase 1, mast cell, mast cell protease 1243817154NM_053835b, ggclathrin, light polypeptide (Lca), clathrin,light polypeptide (Lcb), expressedsequence AV026556243817155NM_053835gclathrin, light polypeptide (Lca), clathrin,light polypeptide (Lcb), expressedsequence AV026556243818065NM_053835cclathrin, light polypeptide (Lca), clathrin,light polypeptide (Lcb), expressedsequence AV026556160417108AI639017IICLLL8 protein, EST, Highly similar toS30385 G9a protein [H. sapiens], ESTs,Weakly similar to T17453 ERG-associated protein ESET - mouse[M. musculus], SET domain, bifurcated 1,euchromatic histone methyltransferase1, suppressor of variegation 3-9(Drosophila) homolog 2; hypotheticalprotein FLJ2341425019952NM_080902cc, ddCLST 11240 protein, DKFZP564K247protein, ESTs, Highly similar to T14766hypothetical protein DKFZp564K247.1[H. sapiens], ESTs, Weakly similar tohypoxia induced gene 1 [Rattusnorvegicus] [R. norvegicus], Homosapiens mRNA; cDNA DKFZp434A1627(from clone DKFZp434A1627), RIKENcDNA 2010110M21 gene, RIKEN cDNA2310056K19 gene, hypothetical proteinMGC2198, hypoxia induced gene 1185624874NM_013057rcoagulation factor III, coagulation factorIII (thromboplastin, tissue factor)254619894NM_138518t, IICocoacrisp, EST, Highly similar toepididymal glycoprotein [Rattusnorvegicus] [R. norvegicus], acidicepididymal glycoprotein 1, acidicepididymal glycoprotein 2, epididymalglycoprotein, glioma pathogenesis-related protein9918012AI058330ee, ff, kkComplement component 4 bindingprotein, alpha, Mus musculus decayaccelerating factorglycosylphoshatidylinositol-anchoredform (DAF) mRNA, partial cds,complement component 4 bindingprotein, complement component 4binding protein, alpha, decayaccelerating factor 1, expressedsequence AI195242, expressedsequence AI323748, zona pellucida 3receptor19624128AA849766bbcomponent of oligomeric golgi complex 4135824129AI177590bcomponent of oligomeric golgi complex 421016585NM_022266q, kkconnective tissue growth factor142822915AI228299bbcraniofacial development protein 12009468NM_017348w, xCreatine transporter [human,brainstem/spinal cord, mRNA, 2283 nt],ESTs, Highly similar to G02277 creatinetransporter [H. sapiens], Mus musculus,Similar to solute carrier family 6(neurotransmitter transporter, GABA),member 13, clone MGC: 28956IMAGE: 4240641, mRNA, complete cds,X transporter protein 3, expressedsequence AA589632, solute carrierfamily 6 (neurotransmitter transporter,creatine), member 8125422958AI171374p, q, tCTAGE-1 protein, ESTs, Moderatelysimilar to MEA6_HUMAN MENINGIOMA-EXPRESSED ANTIGEN 6/11 (MEA6)(MEA11) [H. sapiens], ESTs, Weaklysimilar to MEA6_HUMAN MENINGIOMA-EXPRESSED ANTIGEN 6/11 (MEA6)(MEA11) [H. sapiens], KIAA0268 protein,meningioma expressed antigen 6 (coiled-coil proline-rich)14517650AI230142w, xC-type (calcium dependent,carbohydrate recognition domain) lectin,superfamily member 13, ESTs, Weaklysimilar to KUCR_RAT Kupffer cellreceptor [R. norvegicus], Kupffer cellreceptor, Langerhans cell specific c-typelectin179217257NM_012766e, aa,cyclin D3bb, ee, ff179217261NM_012766l, mcyclin D37362782AA998565c, l, mcyclin-dependent kinase inhibitor 1C(P57), cyclin-dependent kinase inhibitor1C (p57, Kip2)226811258NM_031327y, z, ee,cysteine rich protein 61, cysteine-rich,ff, ggangiogenic inducer, 61218320770NM_024160n, ocytochrome b-245, alpha polypeptide1795449NM_012786hhcytochrome c oxidase, subunit VIIIb,heme-regulated initiation factor 2-alphakinase1795450NM_012786f, hhcytochrome c oxidase, subunit VIIIb,heme-regulated initiation factor 2-alphakinase5475227AA925924l, o, kkcytokine receptor-like factor 115285228AI233311h, l, n, ocytokine receptor-like factor 123954327NM_053563a, n, o, y,DEAD/H (Asp-Glu-Ala-Asp/His) boxz, jj, kkpolypeptide 20, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103 kD,DEAD/H (Asp-Glu-Ala-Asp/His) boxpolypeptide 39, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNAhelicase, 54 kD), DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 7 (RNAhelicase, 52 kD), EST, Moderately similarto HLA-B-associated transcript 1A; DNAsegment, Chr 17, human D6S81E 1;nuclear RNA helicase Bat1 [Musmusculus] [M. musculus], HLA-B-associated transcript 1A213912422NM_022546n, odeath-associated kinase 3, death-associated protein kinase 1, death-associated protein kinase 3, expressedsequence AI120141, serine/threoninekinase 17a (apoptosis-inducing),serine/threonine kinase 17b (apoptosis-inducing)233216155NM_031810iidefensin beta 1, defensin beta 2,defensin, beta 1; expressed sequenceAW26022121326100NM_022531n, odesmin25024739NM_130400aa, bbdihydrofolate reductase21824504NM_024159ddisabled homolog 1 (Drosophila),disabled homolog 2 (Drosophila),disabled homolog 2, mitogen-responsivephosphoprotein (Drosophila)9397880AI043714iiDKFZP434B0335 protein2453531NM_053951ggDKFZP434I216 protein, ESTs, Highlysimilar to DBS MOUSE GUANINENUCLEOTIDE EXCHANGE FACTORDBS [M. musculus], ESTs, Weakly similarto DBS MOUSE GUANINENUCLEOTIDE EXCHANGE FACTORDBS [M. musculus], ESTs, Weakly similarto TIAM MOUSE T-LYMPHOMAINVASION AND METASTASISINDUCING PROTEIN 1 [M. musculus],Homo sapiens cDNA: FLJ21933 fis,clone HEP04337, KIAA0861 protein,KIAA1209 protein, MCF.2 cell linederived transforming sequence, MCF.2cell line derived transforming sequence-like, RIKEN cDNA 2410008H17 gene, T-cell lymphoma invasion and metastasis2, expressed sequence AA408740,hypothetical protein MGC2780, likelyortholog of mouse common-sitelymphoma/leukemia GEE, mcf.2transforming sequence240124875NM_053583ii, jj, kkDKFZP564D0764 protein, ESTs, Weaklysimilar to zinc finger protein 319 [Musmusculus] [M. musculus], KIAA1805protein, Mus musculus, cloneMGC: 29358 IMAGE: 5038671, mRNA,complete cds, OLF-1/EBF associatedzinc finger gene, RIKEN cDNA4931408L03 gene, early B-cell factorassociated zinc finger protein116610780AI136555cDKFZP564O0823 protein, ESTs, Weaklysimilar to S59856 collagen alpha 1(III)chain precursor - mouse [M. musculus],hypothetical protein DKFZp547D065,hypothetical protein FLJ13725, mucinand cadherin-like, splicing factor 3a,subunit 2, 66 kD48211268AA899969l, mDKFZP566C0424 protein10158347AI059519n, oDKFZP566D213 protein, EST,Moderately similar to EPIDERMALGROWTH FACTOR PRECURSOR[M. musculus], Homo sapiens mRNA;cDNA DKFZp434O0213 (from cloneDKFZp434O0213); partial cds,hypothetical protein MGC11256, nidogen 225801948NM_145092b, l, mDKFZP586G011 protein, ESTs, Weaklysimilar to T08767 probable lamina-associated protein DKFZp586G011.1[H. sapiens], Mus musculus, cloneMGC: 6357 IMAGE: 3493883, mRNA,complete cds74221666AB012214n, oDNA (cytosine-5-)-methyltransferase 1,DNA methyltransferase (cytosine-5) 1,EST, Weakly similar to JE0378 DNA(cytosine-5-)-methyltransferase (EC2.1.1.37) - rat [R. norvegicus], F-box andleucine-rich repeat protein 11, Musmusculus DNA cytosinemethyltransferase mRNA, methyl-CpGbinding domain protein 1, proteincontaining CXXC domain 222831822NM_031553iiDNA polymerase epsilon, subunit 3,ESTs, Moderately similar to CCAAT-BINDING TRANSCRIPTION FACTORSUBUNIT A [M. musculus], ESTs,Weakly similar to A23692 transcriptionfactor, CCAAT-binding, chain A1 - rat[R. norvegicus], RIKEN cDNA1810034K18 gene, down-regulator oftranscription 1, down-regulator oftranscription 1, TBP-binding (negativecofactor 2), nuclear transcription factorY, beta, nuclear transcription factor-Ybeta, polymerase (DNA directed),epsilon 3 (p17 subunit)16502401AJ011607uDNA primase, p58 subunit, primase,polypeptide 2A (58 kD)224823568NM_031122eDNA segment, Chr 1, Brigham &Women's Genetics 0212 expressed,EST, Weakly similar to suppression oftumorigenicity 13 (colon carcinoma)Hsp70-interacting protein [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to suppression oftumorigenicity 13 (colon carcinoma)Hsp70-interacting protein [Rattusnorvegicus] [R. norvegicus], RIKENcDNA 1700010I24 gene, RIKEN cDNA2310040B03 gene, expressed sequenceAW538196, sperm associated antigen 1,suppression of tumorigenicity 13 (coloncarcinoma) (Hsp70 interacting protein)224823569NM_031122rDNA segment, Chr 1, Brigham &Women's Genetics 0212 expressed,EST, Weakly similar to suppression oftumorigenicity 13 (colon carcinoma)Hsp70-interacting protein [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to suppression oftumorigenicity 13 (colon carcinoma)Hsp70-interacting protein [Rattusnorvegicus] [R. norvegicus], RIKENcDNA 1700010I24 gene, RIKEN cDNA2310040B03 gene, expressed sequenceAW538196, sperm associated antigen 1,suppression of tumorigenicity 13 (coloncarcinoma) (Hsp70 interacting protein)25261824NM_133545j, k, rDNA segment, Chr 10, ERATO Doi 398,expressed, EST, Weakly similar to2102279A protein Tyr phosphatase[Rattus norvegicus] [R. norvegicus],ESTs, Weakly similar to 41 MOUSEPROTEIN 4.1 [M. musculus], proteintyrosine phosphatase, non-receptor type14, protein tyrosine phosphatase, non-receptor type 21225513358NM_031135dDNA segment, Chr 12, ERATO Doi 427,expressed, RIKEN cDNA 7420700M05gene, TGFB inducible early growthresponse, TGFB inducible early growthresponse 2225513359NM_031135s, tDNA segment, Chr 12, ERATO Doi 427,expressed, RIKEN cDNA 7420700M05gene, TGFB inducible early growthresponse, TGFB inducible early growthresponse 2257014463NM_139110iiDNA segment, Chr 17, ERATO Doi 479,expressed, EGF-like module containing,mucin-like, hormone receptor-likesequence 1, EST, Highly similar toT08685 hypothetical proteinDKFZp564O1923.1 [H. sapiens], EST,Weakly similar to EMR1 MOUSE CELLSURFACE GLYCOPROTEIN EMR1PRECURSOR [M. musculus], ESTs,Weakly similar to EMR1 MOUSE CELLSURFACE GLYCOPROTEIN EMR1PRECURSOR [M. musculus], KIAA0758protein, cadherin EGF LAG seven-pas G-type receptor 2, hypothetical proteinFLJ22684, latrophilin210323511NM_022294n, oDNA segment, Chr 17, ERATO Doi 479,expressed, EGF-like module containing,mucin-like, hormone receptor-likesequence 1, EST, Weakly similar toEMR1 MOUSE CELL SURFACEGLYCOPROTEIN EMR1 PRECURSOR[M. musculus], ESTs, Weakly similar toEMR1 MOUSE CELL SURFACEGLYCOPROTEIN EMR1 PRECURSOR[M. musculus], egf-like modulecontaining, mucin-like, hormone receptor-like sequence 1223620812NM_031100g, h, lDNA segment, Chr 3, University ofCalifornia at Los Angeles 2, EST,Weakly similar to RL10 MOUSE 60SRIBOSOMAL PROTEIN L10[M. musculus], EST, Weakly similar toRL10_MOUSE 60S ribosomal proteinL10 (QM protein homolog)[R. norvegicus], ribosomal protein 10,ribosomal protein L10, ribosomal proteinL10-like26251283U61729cc, dd, llDNA segment, Chr 4, Brigham &Women's Genetics 0593 expressed,ESTs, Moderately similar to JC4899proline rich protein - rat [R. norvegicus],RIKEN cDNA 0610011E17 gene,hypothetical protein FLJ20312, prolinerich 2224216847NM_031109h, l, xDNA segment, Chr 4, ERATO Doi 429,expressed, EST, Weakly similar to2113200G ribosomal protein S10[H. sapiens], EST, Weakly similar toribosomal protein S10 [H. sapiens],ESTs, Highly similar to 2113200Gribosomal protein S10 [H. sapiens],ESTs, Highly similar to RS10 RAT 40SRIBOSOMAL PROTEIN S10[R. norvegicus], ESTs, Moderately similarto RIKEN cDNA 2210402A09 [Musmusculus] [M. musculus], RIKEN cDNA2210402A09 gene, ribosomal proteinS1046116434AA894174h, lDNA segment, Chr 9, ERATO Doi 394,expressed, Mus musculus, Similar toelectron-transfer-flavoprotein, alphapolypeptide (glutaric aciduria II), cloneMGC: 6481 IMAGE: 2646522, mRNA,complete cds, electron-transfer-flavoprotein, alpha polypeptide (glutaricaciduria II)214521115NM_022602j, kDNA segment, Chr X, CelltechChiroscience 3, Mus musculus, serinethreonine kinase pim3, cloneMGC: 27707 IMAGE: 4924687, mRNA,complete cds, pim-1 oncogene, pim-2oncogene, proviral integration site 12917137AA799438ee, ff, jj,DNA segment, EST 1068184, ESTs,kkHighly similar to S68418 proteinphosphatase 1M chain M110 isoform -rat [R. norvegicus], ESTs, Weakly similarto S68418 protein phosphatase 1Mchain M110 isoform - rat (fragment)[R. norvegicus], ESTs, Weakly similar toT42713 ankyrin 3, splice form 1 - mouse[M. musculus], RIKEN cDNA1810037O03 gene, ankyrin repeat andSOCS box-containing 1, ankyrin repeatand SOCS box-containing 2, ankyrinrepeat and SOCS box-containing 3,leukocyte receptor cluster (LRC)member 3, protein phosphatase 1,regulatory (inhibitor) subunit 12A22071048NM_030863s, t, hhDNA segment, KIST 6, ESTs,Moderately similar to T47177hypothetical protein DKFZp762H157.1[H. sapiens], ESTs, Weakly similar toMOES MOUSE MOESIN [M. musculus],RIKEN cDNA 4933415I03 gene,expressed sequence AA408511,moesin, radixin, villin 2 (ezrin)226223097NM_031145n, o, cc,DNA-dependent protein kinase catalyticddsubunit-interacting protein 3, EST,Moderately similar to A Chain A,Homology-Based Model Of Apo Cib[H. sapiens], ESTs, Weakly similar toCIB_HUMAN SNK INTERACTINGPROTEIN 2-28 [H. sapiens], ESTs,Weakly similar to KIP1_RAT DNA-PKcsinteracting protein (Kinase interactingprotein) (KIP) (Calcium and integrin-binding protein) (CIB) [R. norvegicus],Mus musculus ,Similar to protein kinase,DNA activated, catalytic polypeptideinteracting protein, clone MGC: 7098IMAGE: 3157513, mRNA, complete cds,RIKEN cDNA 1700041E20 gene,calcium and integrin binding 1 (calmyrin)24616318AA859648p, qDnaJ (Hsp40) homolog, subfamily A,member 1, DnaJ (Hsp40) homolog,subfamily A, member 4, DnaJ (Hsp40)homolog, subfamily B, member 1, DnaJ(Hsp40) homolog, subfamily B, member12, ESTs, Weakly similar toDJA1_MOUSE DnaJ homolog subfamilyA member 1 (Heat shock 40 kDa protein4) (DnaJ protein homolog 2) (HSJ-2)[R. norvegicus], ESTs, Weakly similar toHSJ2_HUMAN DNAJ PROTEINHOMOLOG 2 [H. sapiens], Homo sapienscDNA FLJ13992 fis, cloneY79AA1002139, weakly similar to DNAJPROTEIN HOMOLOG 1, RIKEN cDNA1700014P03 gene, RIKEN cDNA2010306G19 gene, RIKEN cDNA5730551F12 gene, similar to MRJ genefor a member of the DNAJ protein family(H. sapiens) 1036892AA800551e, ee, ff,DnaJ (Hsp40) homolog, subfamily A,iimember 1, DnaJ (Hsp40) homolog,subfamily A, member 4, ESTs, Highlysimilar to HS44 MOUSE HEAT SHOCK40 KDA PROTEIN 4 [M. musculus],ESTs, Moderately similar toDJA1_MOUSE DnaJ homolog subfamilyA member 1 (Heat shock 40 kDa protein4) (DnaJ protein homolog 2) (HSJ-2)[R. norvegicus], ESTs, Weakly similar toDnaJ-like protein [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar toHS44 MOUSE HEAT SHOCK 40 KDAPROTEIN 4 [M. musculus], Homosapiens mRNA full length insert cDNAclone EUROIMAGE 730912, Musmusculus SEC63 (Sec63) mRNA,complete cds, similar to DNAJ21616891NM_022934ee, ffDnaJ (Hsp40) homolog, subfamily A,member 1, DnaJ (Hsp40) homolog,subfamily A, member 4, ESTs, Highlysimilar to HS44 MOUSE HEAT SHOCK40 KDA PROTEIN 4 [M. musculus],ESTs, Moderately similar toDJA1_MOUSE DnaJ homolog subfamilyA member 1 (Heat shock 40 kDa protein4) (DnaJ protein homolog 2) (HSJ-2)[R. norvegicus], ESTs, Weakly similar toDnaJ-like protein [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar toHS44 MOUSE HEAT SHOCK 40 KDAPROTEIN 4 [M. musculus], Homosapiens mRNA full length insert cDNAclone EUROIMAGE 730912, Musmusculus SEC63 (Sec63) mRNA,complete cds, similar to DNAJ125218047AI171359bbDnaJ (Hsp40) homolog, subfamily A,member 1, DnaJ (Hsp40) homolog,subfamily B, member 6, DnaJ-likeprotein, ESTs, Highly similar to HS44MOUSE HEAT SHOCK 40 KDAPROTEIN 4 [M. musculus], Homosapiens mRNA full length insert cDNAclone EUROIMAGE 730912, RIKENCDNA 4930483N21 gene7693808AI008643p, q, ee,DnaJ (Hsp40) homolog, subfamily B,ffmember 1, DnaJ (Hsp40) homolog,subfamily B, member 5, Homo sapienscDNA FLJ25366 fis, clone TST01784,RIKEN cDNA 1700014P03 gene, RIKENcDNA 2010306G19 gene, RIKEN cDNA5730551F12 gene, hypothetical proteinFLJ142816575990AA956907u, vDnaJ (Hsp40) homolog, subfamily C,member 8, Homo sapiens cDNAFLJ13613 fis, clone PLACE1010856,Homo sapiens mRNA; cDNADKFZp434C2016 (from cloneDKFZp434C2016), hypothetical proteinDKFZp434B227208018946NM_021584s, tdoublecortex; lissencephaly, X-linked(doublecortin), doublecortin2621399U31668p, qE2F transcription factor 4, p107/p130-binding, E2F transcription factor 5, E2Ftranscription factor 5, p130-binding,ESTs, Moderately similar to E2F5MOUSE TRANSCRIPTION FACTORE2F5 [M. musculus], ESTs, Moderatelysimilar to E2F5_RAT TRANSCRIPTIONFACTOR E2F5 (E2F-5) [R. norvegicus],Mus musculus ,Similar to E2Ftranscription factor 4, p107/p130-binding,clone MGC: 37558 IMAGE: 4987691,mRNA, complete cds114624375AI104979j, kEBNA1 binding protein 2, ESTs,Moderately similar to EBNA1 bindingprotein 2; nucleolar protein p40; homologof yeast EBNA1-binding protein; nuclearFGF3 binding protein; EBNA1-bindingprotein 2 [Homo sapiens] [H. sapiens]215117586NM_022694w, xEBNA-2 co-activator (100 kD), ESTs,Moderately similar to I38968 100 kDacoactivator [H. sapiens], staphylococcalnuclease domain containing 1166722762D89730bbEGF-containing fibulin-like extracellularmatrix protein 1, ESTs, Weakly similar toJC5621 epidermal growth factor-likeprotein, T16 precursor - rat[R. norvegicus], Mus musculus ,Similar toEGF-containing fibulin-like extracellularmatrix protein 1, clone IMAGE: 5357328,mRNA, partial cds, epidermal growthfactor-containing fibulin-like extracellularmatrix protein 1, epidermal growth factor-containing fibulin-like extracellular matrixprotein 2256817868NM_139104r, s, tEGF-like-domain, multiple 6, ESTs,Moderately similar to T17324hypothetical protein DKFZp564P2063.1[H. sapiens], ESTs, Weakly similar toMEGF6 [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar tofibulin 5 [Mus musculus] [M. musculus],ESTs, Weakly similar to T09065hypothetical protein - mouse[M. musculus], ESTs, Weakly similar toT17324 hypothetical proteinDKFZp564P2063.1 [H. sapiens], ESTs,Weakly similar to TIE1 MOUSETYROSINE-PROTEIN KINASERECEPTOR TIE-1 PRECURSOR[M. musculus], MEGF6, NEU1 protein,RIKEN cDNA 6130401L20 gene,expressed sequence AW047140155013293AI235032hhELAV (embryonic lethal, abnormalvision, Drosophila)-like 2 (Hu antigen B),ELAV (embryonic lethal, abnormalvision, Drosophila)-like 4 (Hu antigen D),ESTs, Highly similar to ELV4_RAT ELAV-like protein 4 (Paraneoplasticencephalomyelitis antigen HuD) (Hu-antigen D) [R. norvegicus], ESTs,Moderately similar to ELV4_RAT ELAV-like protein 4 (Paraneoplasticencephalomyelitis antigen HuD) (Hu-antigen D) [R. norvegicus], ESTs, Weaklysimilar to HUD_HUMANPARANEOPLASTICENCEPHALOMYELITIS ANTIGEN HUD[H. sapiens]139017358AI179147gelectron-transfer-flavoprotein, betapolypeptide132817920AI176422llelectron-transferring-flavoproteindehydrogenase9437913AI043849ee, ffELL-related RNA polymerase II,elongation factor, ESTs, Weakly similarto ELL MOUSE RNA POLYMERASE IIELONGATION FACTOR ELL[M. musculus], Mus musculus ,cloneIMAGE: 3583970, mRNA, partial cds,RIKEN cDNA 9430098E02 gene, eleven-nineteen lysine-rich leukemia gene,hypothetical protein FLJ2263766923732AA957653ee, ffEna-vasodilator stimulatedphosphoprotein, RNB6, enabledhomolog (Drosophila), expressedsequence AI528774, likely ortholog ofmouse NPC derived proline rich protein1, vasodilator-stimulated phosphoprotein3526535AA891746l, mendothelial differentiation-related factor1, expressed sequence AA409425182818694NM_012931j, k, ggenhancer of filamentation 1 (cas-likedocking; Crk-associated substraterelated), expressed sequence AI385681,neural precursor cell expressed,developmentally down-regulated gene 9,signal transduction protein (SH3containing), v-crk-associated tyrosinekinase substrate182818695NM_012931j, k, y, zenhancer of filamentation 1 (cas-likedocking; Crk-associated substraterelated), expressed sequence AI385681,neural precursor cell expressed,developmentally down-regulated gene 9,signal transduction protein (SH3containing), v-crk-associated tyrosinekinase substrate38923194AA892417ggephrin A1, ephrin-A1220521509NM_030847h, l, n, oepithelial membrane protein 3173725365NM_012519u, v, llER to nucleus signalling 1, ESTs,Weakly similar to A34366Ca2+/calmodulin-dependent proteinkinase (EC 2.7.1.123) II delta chain - rat[R. norvegicus], Mus musculus ,cloneMGC: 18731 IMAGE: 3980838, mRNA,complete cds, calcium/calmodulin-dependent protein kinase (CaM kinase)II alpha, calcium/calmodulin-dependentprotein kinase (CaM kinase) II delta,calcium/calmodulin-dependent proteinkinase II, delta17372735NM_012519rER to nucleus signalling 1, ESTs,Weakly similar to A34366Ca2+/calmodulin-dependent proteinkinase (EC 2.7.1.123) II delta chain - rat[R. norvegicus], Mus musculus ,cloneMGC: 18731 IMAGE: 3980838, mRNA,complete cds, calcium/calmodulin-dependent protein kinase (CaM kinase)II alpha, calcium/calmodulin-dependentprotein kinase (CaM kinase) II delta,calcium/calmodulin-dependent proteinkinase II, delta17372736NM_012519j, kER to nucleus signalling 1, ESTs,Weakly similar to A34366Ca2+/calmodulin-dependent proteinkinase (EC 2.7.1.123) II delta chain - rat[R. norvegicus], Mus musculus ,cloneMGC: 18731 IMAGE: 3980838, mRNA,complete cds, calcium/calmodulin-dependent protein kinase (CaM kinase)II alpha, calcium/calmodulin-dependentprotein kinase (CaM kinase) II delta,calcium/calmodulin-dependent proteinkinase II, delta21368596NM_022538llER transmembrane protein Dri 42,RIKEN cDNA 1810019D05 gene,phosphatidic acid phosphatase 2a,phosphatidic acid phosphatase type 2A,phosphatidic acid phosphatase type 2B,phosphatidic acid phosphatase type 2C,phosphatidic acid phosphatase type 2c21368597NM_022538aa, bb,ER transmembrane protein Dri 42,kk, llRIKEN cDNA 1810019D05 gene,phosphatidic acid phosphatase 2a,phosphatidic acid phosphatase type 2A,phosphatidic acid phosphatase type 2B,phosphatidic acid phosphatase type 2C,phosphatidic acid phosphatase type 2c207116NM_019386cc, dd,erythrocyte membrane protein band 4.2,kktransglutaminase 2 (C polypeptide,protein-glutamine-gamma-glutamyltransferase), transglutaminase2, C polypeptide, transglutaminase 3 (Epolypeptide, protein-glutamine-gamma-glutamyltransferase), transglutaminase3, E polypeptide, transglutaminase 5,transglutaminase Z22304684NM_031083b, l, mEST AA437822, Homo sapiens, Similarto phosphatidylinositol 4-kinase,catalytic, alpha polypeptide, cloneMGC: 31920 IMAGE: 4565073, mRNA,complete cds, phosphatidylinositol 4-kinase, catalytic, alpha polypeptide,phosphatidylinositol 4-kinase, catalytic,beta polypeptide, phosphoinositide-3-kinase, catalytic, gamma polypeptide84721796AI012221a, n, o, x,EST X83352, ESTs, Weakly similar toz, kkintracellular chloride ion channel proteinp64H1 [Rattus norvegicus][R. norvegicus], RIKEN cDNA5730531E12 gene, chloride intracellularchannel 1, chloride intracellular channel3, chloride intracellular channel 4(mitochondrial), intracellular chloride ionchannel protein p64H1111911721AI103391ee, ffEST, Highly similar tophosphatidylinositol 3-kinase, regulatorysubunit, polypeptide [Rattus norvegicus][R. norvegicus], ESTs, Moderately similarto P55G_MOUSEPHOSPHATIDYLINOSITOL 3-KINASEREGULATORY GAMMA SUBUNIT (PI3-KINASE P85-GAMMA SUBUNIT)(PTDINS-3-KINASE P85-GAMMA)(P55PIK) [M. musculus],phosphatidylinositol 3-kinase, regulatorysubunit, polypeptide 2 (p85 beta),phosphoinositide-3-kinase, regulatorysubunit, polypeptide 2 (p85 beta)205410015NM_019289n, o, jj,EST, Highly similar to AR41_HUMANkk, llARP2/3 COMPLEX 41 KDA SUBUNIT[H. sapiens], actin related protein 2/3complex, subunit 1B (41 kD), actinrelated protein 2/3 complex, subunit 1B(41 kDa)205410016NM_019289a, o, jj,EST, Highly similar to AR41_HUMANkk, llARP2/3 COMPLEX 41 KDA SUBUNIT[H. sapiens], actin related protein 2/3complex, subunit 1B (41 kD), actinrelated protein 2/3 complex, subunit 1B(41 kDa)172224662M59786l, m, jj,EST, Highly similar to CCAC_RATkkVoltage-dependent L-type calciumchannel alpha-1C subunit (Calciumchannel, L type, alpha-1 polypeptide,isoform 1, cardiac muscle) (RAT brainclass C) (RBC) [R. norvegicus], ESTs,Highly similar to CCAC_HUMANVOLTAGE-DEPENDENT L-TYPECALCIUM CHANNEL ALPHA-1CSUBUNIT [H. sapiens], ESTs, Highlysimilar to CCAD_HUMAN VOLTAGE-DEPENDENT L-TYPE CALCIUMCHANNEL ALPHA-1D SUBUNIT[H. sapiens], Mus musculus putative ionchannel protein CATSPER2 mRNA,complete cds, calcium channel, voltage-dependent, L type, alpha 1C subunit158322939AI236669y, z, jj, kkEST, Highly similar to DPOZ_HUMANDNA POLYMERASE ZETA CATALYTICSUBUNIT [H. sapiens], ESTs, Highlysimilar to DPOZ_HUMAN DNAPOLYMERASE ZETA CATALYTICSUBUNIT [H. sapiens], ESTs, Weaklysimilar to DPOZ_HUMAN DNAPOLYMERASE ZETA CATALYTICSUBUNIT [H. sapiens], REV3-like,catalytic subunit of DNA polymerasezeta (yeast), REV3-like, catalytic subunitof DNA polymerase zeta RAD54 like (S.cerevisiae), expressed sequenceC77370, expressed sequence C77386189416448NM_013197b, c, vEST, Highly similar to HEM0_RAT 5-AMINOLEVULINIC ACID SYNTHASE,ERYTHROID-SPECIFIC,MITOCHONDRIAL PRECURSOR(DELTA-AMINOLEVULINATESYNTHASE) (DELTA-ALASYNTHETASE) (ALAS-E)[R. norvegicus], ESTs, Highly similar toSYHUAE 5-aminolevulinate synthase[H. sapiens], aminolevulinate, delta-,synthase 2 (sideroblastic/hypochromicanemia), aminolevulinic acid synthase 1,aminolevulinic acid synthase 2,erythroid, glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme Aligase), glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme Aligase)76415849AI008074r, llEST, Highly similar to HS9B MOUSEHEAT SHOCK PROTEIN HSP 90-BETA[M. musculus], EST, Weakly similar toHHMS84 heat shock protein 84 - mouse[M. musculus], ESTs, Highly similar toHS9A_HUMAN HEAT SHOCK PROTEINHSP 90-ALPHA [H. sapiens], ESTs,Highly similar to T46243 hypotheticalprotein DKFZp761K0511.1 [H. sapiens],expressed sequence C81438, heatshock 90 kD protein 1, beta, heat shockprotein, 84 kDa 1, heat shock protein, 86kDa 1631643AA946439dEST, Highly similar to HSRT4 histone H4 -rat [R. norvegicus], EST, Moderatelysimilar to HSHU4 histone H4[H. sapiens], H4 histone family, memberE, Mus musculus 10 day old malepancreas cDNA, RIKEN full-lengthenriched library,clone: 1810029H14: histone 4 protein, fullinsert sequence, Mus musculus adultmale tongue cDNA, RIKEN full-lengthenriched library,clone: 2310067E17: histone 4 protein, fullinsert sequence246115468NM_053982j, w, x, jj,EST, Highly similar to JC2234 ribosomalkkprotein S15a, cytosolic [validated] - rat[R. norvegicus], ESTs, Highly similar toRS1A_HUMAN 40S RIBOSOMALPROTEIN S15A [H. sapiens], ribosomalprotein S15a268618031X94551f, rEST, Highly similar to MYHA_RATMyosin heavy chain, nonmuscle type B(Cellular myosin heavy chain, type B)(Nonmuscle myosin heavy chain-B)(NMMHC-B) [R. norvegicus], ESTs,Highly similar to MYHA_MOUSE Myosinheavy chain, nonmuscle type B (Cellularmyosin heavy chain, type B) (Nonmusclemyosin heavy chain-B) (NMMHC-B)[M. musculus], Homo sapiens cDNA:FLJ23324 fis, clone HEP12482, highlysimilar to HUMMYOHCB Humannonmuscle myosin heavy chain-B(MYH10) mRNA, Myosin heavy chain 11,RIKEN cDNA 5730504C04 gene,laminin, gamma 1148020845AI231140w, xEST, Highly similar to R3RT3Aribosomal protein L23a, cytosolic[validated] - rat [R. norvegicus], EST,Weakly similar to E54024 protein kinase[H. sapiens], ESTs, Highly similar to 60SRIBOSOMAL PROTEIN L23A[R. norvegicus], ESTs, Highly similar toRL2B_HUMAN 60S RIBOSOMALPROTEIN L23A [H. sapiens], Musmusculus, ribosomal protein L23a, cloneIMAGE: 4988735, mRNA, partial cds,ribosomal protein L23a267120844X65228f, g, cc,EST, Highly similar to R3RT3Addribosomal protein L23a, cytosolic[validated] - rat [R. norvegicus], EST,Weakly similar to E54024 protein kinase[H. sapiens], ESTs, Highly similar to 60SRIBOSOMAL PROTEIN L23A[R. norvegicus], ESTs, Highly similar toRL2B_HUMAN 60S RIBOSOMALPROTEIN L23A [H. sapiens], Musmusculus, ribosomal protein L23a, cloneIMAGE: 4988735, mRNA, partial cds,ribosomal protein L23a40415876AA892582g, w, xEST, Highly similar to RL8_HUMAN 60Sribosomal protein L8 [R. norvegicus],EST, Weakly similar to JN0923ribosomal protein L8, cytosolic[H. sapiens], ESTs, Highly similar toR5RTL8 ribosomal protein L8, cytosolic[validated] - rat [R. norvegicus], ESTs,Highly similar to RL8_HUMAN 60SRIBOSOMAL PROTEIN L [M. musculus],ESTs, Moderately similar toRL8_HUMAN 60S RIBOSOMALPROTEIN L [M. musculus], expressedsequence AL024098, ribosomal proteinL8148121816AI231217llEST, Highly similar to S611_HUMANProtein transport protein Sec61 alphasubunit isoform 1 (Sec61 alpha-1)[R. norvegicus], ESTs, Highly similar toS611_HUMAN Protein transport proteinSec61 alpha subunit isoform 1 (Sec61alpha-1) [R. norvegicus], SEC61, alphasubunit (S. cerevisiae), SEC61, alphasubunit 2 (S. cerevisiae), Sec61 alphaform 2, protein transport protein SEC61alpha subunit isoform 167123644AA957808ggEST, Highly similar to SNX9_HUMANSORTING NEXIN 9 (SH3 AND PXDOMAIN-CONTAINING PROTEIN 1)(SDP1 PROTEIN) [H. sapiens], Homosapiens cDNA FLJ11997 fis, cloneHEMBB1001458, sorting nexin 91786343NM_012747n, oEST, Highly similar to STA3_RAT Signaltransducer and activator of transcription3 [R. norvegicus], signal transducer andactivator of transcription 3, signaltransducer and activator of transcription3 (acute-phase response factor)141614337AI180414b, c, l, mEST, Highly similar to T14106 probableGTPase-activating protein SPA-1 - rat[R. norvegicus], ESTs, Moderately similarto T14106 probable GTPase-activatingprotein SPA-1 - rat [R. norvegicus],KIAA0440 protein, RIKEN cDNA2610511M17 gene, Rap1, GTPase-activating protein 1, SPA-1 like proteinp1294, expressed sequence AW21328769915885AA965207tEST, Highly similar to T14795hypothetical protein DKFZp434E171.1[H. sapiens]4933822AA900863kkEST, Moderately similar to HLA-B-associated transcript 1A; DNA segment,Chr 17, human D6S81E 1; nuclear RNAhelicase Bat1 [Mus musculus][M. musculus], EST, Weakly similar toHE47_RAT Probable ATP-dependentRNA helicase p47 [R. norvegicus], ESTs,Moderately similar to IF41_HUMANEUKARYOTIC INITIATION FACTOR 4A-I [M. musculus], ESTs, Weakly similar toHE47 RAT PROBABLE ATP-DEPENDENT RNA HELICASE P47[R. norvegicus], HLA-B-associatedtranscript 1A, RIKEN cDNA 2410004K13gene, RIKEN cDNA 2600001H07 gene,RIKEN cDNA 2610307C23 gene,eukaryotic translation initiation factor 4A,isoform 1, eukaryotic translation initiationfactor 4A115243823AI233147y, zEST, Moderately similar to HLA-B-associated transcript 1A; DNA segment,Chr 17, human D6S81E 1; nuclear RNAhelicase Bat1 [Mus musculus][M. musculus], EST, Weakly similar toHE47_RAT Probable ATP-dependentRNA helicase p47 [R. norvegicus], ESTs,Moderately similar to IF41_HUMANEUKARYOTIC INITIATION FACTOR 4A-I [M. musculus], ESTs, Weakly similar toHE47 RAT PROBABLE ATP-DEPENDENT RNA HELICASE P47[R. norvegicus], HLA-B-associatedtranscript 1A, RIKEN cDNA 2410004K13gene, RIKEN cDNA 2600001H07 gene,RIKEN cDNA 2610307C23 gene,eukaryotic translation initiation factor 4A,isoform 1, eukaryotic translation initiationfactor 4A112223115AA801165cEST, Moderately similar to RIKEN cDNA1700113O17 [Mus musculus][M. musculus], H2A histone family,member L, Homo sapiens, cloneMGC: 21597 IMAGE: 4511035, mRNA,complete cds, Mus musculus ,similar toH2A histone family, member O, cloneMGC: 36202 IMAGE: 5055276, mRNA,complete cds, expressed sequenceR75370225715485NM_031137l, mEST, Moderately similar totripeptidylpeptidase II [Rattusnorvegicus ][R. norvegicus], ESTs, Highlysimilar to TRIPEPTIDYL-PEPTIDASE II[M. musculus], tripeptidyl peptidase II225715486NM_031137w, xEST, Moderately similar totripeptidylpeptidase II [Rattusnorvegicus ][R. norvegicus], ESTs, Highlysimilar to TRIPEPTIDYL-PEPTIDASE II[M. musculus], tripeptidyl peptidase II118614524AI137974dEST, Moderately similar to 0710252Ahistone H3 [H. sapiens], ESTs, Highlysimilar to I57019 H3 histone - rat[R. norvegicus], ESTs, Weakly similar toI57019 H3 histone - rat [R. norvegicus],H3 histone family, member I, Homosapiens, histone gene complex 1, cloneMGC: 9629 IMAGE: 3913365, mRNA,complete cds714980AI103396l, mEST, Moderately similar to 0806162Bcytochrome b [M. musculus], EST,Moderately similar to 810024Bcytochrome b [H. sapiens], EST, Weaklysimilar to 0806162B cytochrome b[M. musculus], EST, Weakly similar to0812187A cytochrome b [Rattusnorvegicus ][R. norvegicus], EST, Weaklysimilar to 810024M URF 6 [H. sapiens]714981AI103396eEST, Moderately similar to 0806162Bcytochrome b [M. musculus], EST,Moderately similar to 810024Bcytochrome b [H. sapiens], EST, Weaklysimilar to 0806162B cytochrome b[M. musculus], EST, Weakly similar to0812187A cytochrome b [Rattusnorvegicus ][R. norvegicus], EST, Weaklysimilar to 810024M URF 6 [H. sapiens]814983AI179150bb, cc,EST, Moderately similar to 0806162Bddcytochrome b [M. musculus], EST,Moderately similar to 810024Bcytochrome b [H. sapiens], EST, Weaklysimilar to 0806162B cytochrome b[M. musculus], EST, Weakly similar to0812187A cytochrome b [Rattusnorvegicus ][R. norvegicus], EST, Weaklysimilar to 810024M URF 6 [H. sapiens]112916136AI103983p, qEST, Moderately similar to 0806162Cprotein COI [M. musculus], EST,Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], EST,Weakly similar to 0806162C protein COI[M. musculus], ESTs, Moderately similarto 0806162C protein COI [M. musculus],ESTs, Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], ESTs,Weakly similar to 0806162C protein COI[M. musculus]916130J01435bbEST, Moderately similar to 0806162Cprotein COI [M. musculus], EST,Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], EST,Weakly similar to 0806162C protein COI[M. musculus], ESTs, Moderately similarto 0806162C protein COI [M. musculus],ESTs, Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], ESTs,Weakly similar to 0806162C protein COI[M. musculus]238816135NM_053516aa, bbEST, Moderately similar to 0806162Cprotein COI [M. musculus], EST,Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], EST,Weakly similar to 0806162C protein COI[M. musculus], ESTs, Moderately similarto 0806162C protein COI [M. musculus],ESTs, Moderately similar to 810024Ccytochrome oxidase I [H. sapiens], ESTs,Weakly similar to 0806162C protein COI[M. musculus]24441570NM_053857s, tEST, Moderately similar to 2021415Ainitiation factor 4E-bindingprotein: ISOTYPE = 1 [H. sapiens], ESTs,Weakly similar to A55258 insulin-stimulated phosphoprotein PHAS-I - rat[R. norvegicus], RIKEN cDNA1110004O12 gene, eukaryotictranslation initiation factor 4E bindingprotein 1, eukaryotic translation initiationfactor 4E binding protein 2, eukaryotictranslation initiation factor 4E bindingprotein 324441571NM_053857e, t, kkEST, Moderately similar to 2021415Ainitiation factor 4E-bindingprotein: ISOTYPE = 1 [H. sapiens], ESTs,Weakly similar to A55258 insulin-stimulated phosphoprotein PHAS-I - rat[R. norvegicus], RIKEN cDNA1110004O12 gene, eukaryotictranslation initiation factor 4E bindingprotein 1, eukaryotic translation initiationfactor 4E binding protein 2, eukaryotictranslation initiation factor 4E bindingprotein 3266815387X62482w, xEST, Moderately similar to 40SRIBOSOMAL PROTEIN S25[R. norvegicus], EST, Moderately similarto R3RT25 ribosomal protein S25,cytosolic [validated] - rat [R. norvegicus],EST, Weakly similar to 40SRIBOSOMAL PROTEIN S25[R. norvegicus], EST, Weakly similar toJQ1347 ribosomal protein S25, cytosolic[H. sapiens], ESTs, Highly similar toJQ1347 ribosomal protein S25, cytosolic[H. sapiens], ribosomal protein S25253414995NM_133624dEST, Moderately similar to A Chain A,Structure Of Human Guanylate BindingProtein-1 In Nucleotide Free Form[H. sapiens], ESTs, Weakly similar toINTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 [M. musculus],Homo sapiens mRNA; cDNADKFZp564C2478 (from cloneDKFZp564C2478); complete cds,guanylate binding protein 1, interferon-inducible, 67 kD, guanylate bindingprotein 2, interferon-inducible, guanylatenucleotide binding protein 1, guanylatenucleotide binding protein 2225915185NM_031140n, bb, llEST, Moderately similar to A25074vimentin [H. sapiens], EST, Weaklysimilar to A25074 vimentin [H. sapiens],ESTs, Weakly similar to A25074vimentin [H. sapiens], Mus musculus,similar to FLJ00074 protein, cloneMGC: 36549 IMAGE: 4952810, mRNA,complete cds, desmuslin, intermediatefilament-like MGC: 2625, vimentin93323950AI031019s, tEST, Moderately similar to A55146guanine nucleotide exchange factor elF-2B delta chain, long form - mouse[M. musculus], ESTs, Moderately similarto E2BA_HUMAN TRANSLATIONINITIATION FACTOR EIF-2B ALPHASUBUNIT [H. sapiens], ESTs, Weaklysimilar to 2112359A initiation factor elF-2B [Rattus norvegicus] [R. norvegicus],Mus musculus ,Similar to eukaryotictranslation initiation factor 2B, subunit 1(alpha, 26 kD), clone MGC: 6458IMAGE: 2615801, mRNA, complete cds,Mus musculus ,Similar to eukaryotictranslation initiation factor 2B, subunit 2(beta, 39 kD), clone MGC: 7057IMAGE: 3156632, mRNA, complete cds,RIKEN CDNA 2410018C20 gene,eukaryotic translation initiation factor 2B,subunit 1 (alpha, 26 kD)113121927AI104117w, xEST, Moderately similar toCL36_HUMAN LIM DOMAIN PROTEINCLP-36 [H. sapiens], ESTs, Weaklysimilar to A55050 enigma [H. sapiens],ESTs, Weakly similar to PDL1_RAT PDZand LIM domain protein 1 (LIM domainprotein CLP-36) (C-terminal LIM domainprotein 1) (Elfin) [R. norvegicus], Homosapiens cDNA: FLJ23564 fis, cloneLNG10773, Homo sapiens, Similar toenigma homolog (R. norvegicus), cloneMGC: 23807 IMAGE: 4271274, mRNA,complete cds, LIM domain binding 3,PDZ and LIM domain 1 (elfin), PDZ andLIM domain 3, RIKEN cDNA2410002J21 gene, expressed sequenceAV278559, expressed sequenceAW123232, paxillin, transforming growthfactor beta 1 induced transcript 17463799AF002281p, u, v,EST, Moderately similar toee, ff, kkCL36_HUMAN LIM DOMAIN PROTEINllCLP-36 [H. sapiens], ESTs, Weaklysimilar to PDL1_RAT PDZ and LIMdomain protein 1 (LIM domain proteinCLP-36) (C-terminal LIM domain protein1) (Elfin) [R. norvegicus], Mus musculus,clone MGC: 37634 IMAGE: 4990983,mRNA, complete cds, PDZ and LIMdomain 1 (elfin), PDZ and LIM domain 3,PDZ-LIM protein mystique, Rattusnorvegicus LIM-domain protein LMP-1mRNA, complete cds, alpha-actinin-2-associated LIM protein12917740AI175011r, hhEST, Moderately similar toCOF1_HUMAN COFILIN, NON-MUSCLE ISOFOR [H. sapiens], EST,Weakly similar to COF1_HUMANCOFILIN, NON-MUSCLE ISOFOR[H. sapiens], ESTs, Highly similar toDEST_HUMAN DESTRIN [H. sapiens],ESTs, Moderately similar toCOF1_HUMAN COFILIN, NON-MUSCLE ISOFOR [H. sapiens], Homosapiens cDNA FLJ30934 fis, cloneFEBRA2007017, moderately similar toHomo sapiens TRAF4-associated factor206523225NM_019360cEST, Moderately similar toCOXI_MOUSE Cytochrome c oxidasepolypeptide VIC-2 [R. norvegicus], ESTs,Moderately similar to COXH_HUMANCYTOCHROME C OXIDASEPOLYPEPTIDE VIC PRECURSOR[H. sapiens], cytochrome c oxidasesubunit VIc, cytochrome c oxidase,subunit VIc181220945NM_012875cc, ddEST, Moderately similar to G02654ribosomal protein L39 [H. sapiens], EST,Moderately similar to RL39_HUMAN 60Sribosomal protein L39 [R. norvegicus],ESTs, Highly similar to G02654ribosomal protein L39 [H. sapiens], ESTs,Moderately similar to G02654 ribosomalprotein L39 [H. sapiens], RIKEN cDNA2810465O16 gene, RIKEN cDNA3930402I10 gene, RIKEN cDNA4930517K11 gene, ribosomal proteinL39, ribosomal protein L39-like53223173AA925057h, l, w, xEST, Moderately similar to G02666cysteine-rich protein 1 [H. sapiens],cysteine rich intestinal protein, cysteine-rich protein 1 (intestinal), expressedsequence AW743261260817626S78556ggEST, Moderately similar toGR75_HUMAN MITOCHONDRIALSTRESS-70 PROTEIN PRECURSOR[H. sapiens], ESTs, Highly similar toI56581 dnaK-type molecular chaperonegrp75 precursor - rat [R. norvegicus],ESTs, Moderately similar toGR75_HUMAN MITOCHONDRIALSTRESS-70 PROTEIN PRECURSOR[H. sapiens], heat shock 70 kD protein 9B(mortalin-2), heat shock protein, 74 kDa, A19011495NM_013221y, z, aa, bbEST, Moderately similar to I58311 HMG-box containing protein 1 - rat[R. norvegicus], ESTs, Highly similar toI58311 HMG-box containing protein 1 -rat [R. norvegicus], ESTs, Moderatelysimilar to 158311 HMG-box containingprotein 1 - rat [R. norvegicus], HMG-boxcontaining protein 1, Mus musculus,Similar to protein kinase, lysine deficient4, clone IMAGE: 4973225, mRNA, partialcds, RIKEN cDNA 1200010B10 gene,RIKEN cDNA 1700058O05 gene211022412NM_022392p, qEST, Moderately similar to ISI1_RATInsulin-induced protein 1 (Insulin-induced growth response protein CL-6)(Immediate-early protein CL-6)[R. norvegicus], RIKEN cDNA2900053I11 gene, insulin induced gene1, insulin induced protein 211274402AI103874rEST, Moderately similar to JQ1522peptidylprolyl isomerase [H. sapiens],ESTs, Moderately similar to 1613455AFK506 binding protein FKBP [H. sapiens],FK506 binding protein 3 (25 kD), FK506binding protein 7, FK506 binding protein9 (63 kD), FK506 binding proteinprecursor, hypothetical protein FLJ2073118891314NM_013181fEST, Moderately similar to KAP0_RATCAMP-DEPENDENT PROTEIN KINASETYPE I-ALPHA REGULATORY CHAIN[R. norvegicus], EST, Weakly similar toKAP1 MOUSE CAMP-DEPENDENTPROTEIN KINASE TYPE I-BETAREGULATORY CHAIN [M. musculus],protein kinase, cAMP dependentregulatory, type I beta, protein kinase,cAMP dependent regulatory, type I,alpha, protein kinase, cAMP-dependent,regulatory, type I, alpha (tissue specificextinguisher 1)256218867NM_138900b, cEST, Moderately similar toMAS2_HUMAN MANNAN-BINDINGLECTIN SERINE PROTEASE 2PRECURSOR [H. sapiens], ESTs,Moderately similar to CRAR_HUMANCOMPLEMENT-ACTIVATINGCOMPONENT OF RA-REACTIVEFACTOR PRECURSOR [H. sapiens],Mus musculus ,Similar to complementcomponent 1, s subcomponent, cloneMGC: 19094 IMAGE: 4196654, mRNA,complete cds, Mus musculus ,Similar tocomplement component 1, ssubcomponent, clone MGC: 28492IMAGE: 4166254, mRNA, complete cds,complement component 1, rsubcomponent, complement component1, s subcomponent, mannan-bindinglectin serine protease 22126162NM_022516e, u, vEST, Moderately similar to MDHM_RATMALATE DEHYDROGENASE,MITOCHONDRIAL PRECURSOR[R. norvegicus], EST, Weakly similar toDEMSMM malate dehydrogenase[M. musculus], malate dehydrogenase 2,NAD (mitochondrial), malatedehydrogenase, mitochondrial198920281NM_017274ggEST, Moderately similar to PLSBMOUSE GLYCEROL-3-PHOSPHATEACYLTRANSFERASE,MITOCHONDRIAL PRECURSOR[M. musculus], EST, Weakly similar toPLSB_RAT GLYCEROL-3-PHOSPHATEACYLTRANSFERASE,MITOCHONDRIAL PRECURSOR(GPAT) [R. norvegicus], ESTs, Weaklysimilar to GLYCEROL-3-PHOSPHATEACYLTRANSFERASE PRECURSOR[M. musculus], ESTs, Weakly similar toPLSB MOUSE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE,MITOCHONDRIAL PRECURSOR[M. musculus], KIAA1560 protein,glycerol-3-phosphate acyltransferase,mitochondrial17851478NM_012744n, oEST, Moderately similar to PYC_RATPyruvate carboxylase, mitochondrialprecursor (Pyruvic carboxylase) (PCB)[R. norvegicus], Mus musculus ,Similar toPropionyl Coenzyme A carboxylase,alpha polypeptide, clone MGC: 11973IMAGE: 3601148, mRNA, complete cds,pyruvate carboxylase, pyruvatedecarboxylase119318206AI145282a, jj, kkEST, Moderately similar toRBM8_HUMAN PUTATIVE RNA-BINDING PROTEIN 8 [H. sapiens], ESTs,Moderately similar to NUCLEOLIN[M. musculus], ESTs, Moderately similarto RBM8_HUMAN PUTATIVE RNA-BINDING PROTEIN 8 [H. sapiens], ESTs,Weakly similar to NUCL_HUMANNUCLEOLIN [H. sapiens], Homo sapiens,clone MGC: 22221 IMAGE: 4687764,mRNA, complete cds, Mus musculus,Similar to fusion, derived from t(12; 16)malignant liposarcoma, cloneMGC: 18917 IMAGE: 3153860, mRNA,complete cds, Nucleolin, RNA bindingmotif protein 8A, TAF15 RNApolymerase II, TATA box binding protein(TBP)-associated factor, 68 kDa,eukaryotic translation initiation factor 3,subunit 4 (delta, 44 kDa), nucleolin,pigpen185217174NM_013030l, mEST, Moderately similar toRL17_HUMAN 60S RIBOSOMALPROTEIN L17 [H. sapiens], EST, Weaklysimilar to RL17 RAT 60S RIBOSOMALPROTEIN L17 [R. norvegicus], EST,Weakly similar to RL17_HUMAN 60SRIBOSOMAL PROTEIN L17 [H. sapiens],ESTs, Highly similar to R5HU22ribosomal protein L17, cytosolic[H. sapiens], ESTs, Highly similar toRL17 RAT 60S RIBOSOMAL PROTEINL17 [R. norvegicus], ESTs, Weaklysimilar to R5HU22 ribosomal proteinL17, cytosolic [H. sapiens], Musmusculus adult female placenta cDNA,RIKEN full-length enriched library,clone: 1600029O15: hexokinase 1, fullinsert sequence, ribosomal protein L17266217176X60212fEST, Moderately similar toRL17_HUMAN 60S RIBOSOMALPROTEIN L17 [H. sapiens], EST, Weaklysimilar to RL17 RAT 60S RIBOSOMALPROTEIN L17 [R. norvegicus], EST,Weakly similar to RL17_HUMAN 60SRIBOSOMAL PROTEIN L17 [H. sapiens],ESTs, Highly similar to R5HU22ribosomal protein L17, cytosolic[H. sapiens], ESTs, Highly similar toRL17 RAT 60S RIBOSOMAL PROTEINL17 [R. norvegicus], ESTs, Weaklysimilar to R5HU22 ribosomal proteinL17, cytosolic [H. sapiens], Musmusculus adult female placenta cDNA,RIKEN full-length enriched library,clone: 1600029O15: hexokinase 1, fullinsert sequence, ribosomal protein L174617212AA799571llEST, Moderately similar toRL35_HUMAN 60S RIBOSOMALPROTEIN L3 [H. sapiens], EST,Moderately similar to RL35_RAT 60SRIBOSOMAL PROTEIN L35[R. norvegicus], Homo sapiens, cloneIMAGE: 4183312, mRNA, partial cds,ribosomal protein L35171617211M34331cc, ddEST, Moderately similar toRL35_HUMAN 60S RIBOSOMALPROTEIN L3 [H. sapiens], EST,Moderately similar to RL35_RAT 60SRIBOSOMAL PROTEIN L35[R. norvegicus], Homo sapiens, cloneIMAGE: 4183312, mRNA, partial cds,ribosomal protein L35171626030M34331gEST, Moderately similar toRL35_HUMAN 60S RIBOSOMALPROTEIN L3 [H. sapiens], EST,Moderately similar to RL35_RAT 60SRIBOSOMAL PROTEIN L35[R. norvegicus], Homo sapiens, cloneIMAGE: 4183312, mRNA, partial cds,ribosomal protein L35231816918NM_031709g, h, l, w, xEST, Moderately similar toRS12_HUMAN 40S RIBOSOMALPROTEIN S1 [H. sapiens], ESTs,Moderately similar to R3HU12 ribosomalprotein S12, cytosolic [H. sapiens], ESTs,Moderately similar to RS12 MOUSE 40SRIBOSOMAL PROTEIN S12[M. musculus], ribosomal protein S12233810269NM_031838h, l, w, xEST, Moderately similar to RS2 MOUSE40S RIBOSOMAL PROTEIN S2[M. musculus], EST, Weakly similar toribosomal protein S2; 40S ribosomalprotein S2 [Homo sapiens] [H. sapiens],EST, Weakly similar to RS2_HUMAN40S RIBOSOMAL PROTEIN S2[H. sapiens], EST, Weakly similar toRS2_RAT 40S RIBOSOMAL PROTEINS2 [R. norvegicus], ESTs, Highly similarto ribosomal protein S2; 40S ribosomalprotein S2 [Homo sapiens] [H. sapiens],ESTs, Highly similar to ribosomalprotein S2; repeat family 3 gene [Musmusculus] [M. musculus], Homo sapiens,clone IMAGE: 4816496, mRNA, partialcds, ribosomal protein S2224419162NM_031111h, lEST, Moderately similar to RS21_RAT40S RIBOSOMAL PROTEIN S21[R. norvegicus], ribosomal protein S2178810820AI009411g, h, lEST, Moderately similar to RS3_MOUSE40S ribosomal protein S3 [R. norvegicus],EST, Weakly similar to RS3_MOUSE40S ribosomal protein S3 [R. norvegicus],ESTs, Highly similar to RS3_MOUSE40S ribosomal protein S3 [R. norvegicus],ESTs, Moderately similar toRS3_HUMAN 40S RIBOSOMALPROTEIN S [H. sapiens], ESTs, Weaklysimilar to RS3 MOUSE 40SRIBOSOMAL PROTEIN S3[M. musculus], hypothetical proteinFLJ11252, hypothetical proteinFLJ23059, myo-inositol 1-phosphatesynthase A1, ribosomal protein S3155511644AI235282n, oEST, Moderately similar to S25111 alpha2-macroglobulin receptor precursor -mouse [M. musculus], ESTs, Highlysimilar to S25111 alpha-2-macroglobulinreceptor precursor - mouse[M. musculus], ESTs, Weakly similar toS25111 alpha-2-macroglobulin receptorprecursor - mouse [M. musculus], lowdensity lipoprotein receptor-relatedprotein 1, low density lipoprotein-relatedprotein 1 (alpha-2-macroglobulinreceptor)38313647AA892367w, x, cc,EST, Moderately similar to S34195ddribosomal protein L3, cytosolic[H. sapiens], EST, Weakly similar toS34195 ribosomal protein L3, cytosolic[H. sapiens], ESTs, Highly similar toS34195 ribosomal protein L3, cytosolic[H. sapiens], ESTs, Moderately similar toRL3_RAT 60S RIBOSOMAL PROTEINL3 (L4) [R. norvegicus], ESTs, Weaklysimilar to RL3 MOUSE 60SRIBOSOMAL PROTEIN L3[M. musculus], RIKEN cDNA1110057H16 gene, ribosomal protein L3,ribosomal protein L3-like266713646X62166n, o, w,EST, Moderately similar to S34195x, kk, llribosomal protein L3, cytosolic[H. sapiens], EST, Weakly similar toS34195 ribosomal protein L3, cytosolic[H. sapiens], ESTs, Highly similar toS34195 ribosomal protein L3, cytosolic[H. sapiens], ESTs, Moderately similar toRL3_RAT 60S RIBOSOMAL PROTEINL3 (L4) [R. norvegicus], ESTs, Weaklysimilar to RL3 MOUSE 60SRIBOSOMAL PROTEIN L3[M. musculus], RIKEN cDNA1110057H16 gene, ribosomal protein L3,ribosomal protein L3-like52018251AA924548jj, kkEST, Moderately similar to S65792ribosomal protein L9, cytosolic[H. sapiens], EST, Weakly similar toRL9_RAT 60S RIBOSOMAL PROTEINL9 [R. norvegicus], ESTs, Weakly similarto 60S RIBOSOMAL PROTEIN L9[M. musculus], RIKEN cDNA4930401B11 gene, ribosomal protein L9108215192AI101099j, kEST, Moderately similar to SMHU1Emetallothionein 1E [H. sapiens], ESTs,Highly similar to SMHU1Bmetallothionein 1B [H. sapiens],H. sapiens mRNA for metallothioneinisoform 1R, Homo sapiensmetallothionein 1H-like protein mRNA,complete cds, Homo sapiens unknownmRNA, Homo sapiens, Similar to RNAhelicase-related protein, cloneMGC: 9246 IMAGE: 3892441, mRNA,complete cds, Mus musculus,metallothionein 2A, clone MGC: 30400IMAGE: 4501155, mRNA, complete cds,metallothionein 1H, metallothionein 1X,metallothionein 2133015191AI176456h, l, j, k,EST, Moderately similar to SMHU1Ey, z, ee,metallothionein 1E [H. sapiens], ESTs,ff, kkHighly similar to SMHU1Bmetallothionein 1B [H. sapiens],H. sapiens mRNA for metallothioneinisoform 1R, Homo sapiensmetallothionein 1H-like protein mRNA,complete cds, Homo sapiens unknownmRNA, Homo sapiens, Similar to RNAhelicase-related protein, cloneMGC: 9246 IMAGE: 3892441, mRNA,complete cds, Mus musculus,metallothionein 2A, clone MGC: 30400IMAGE: 4501155, mRNA, complete cds,metallothionein 1H, metallothionein 1X,metallothionein 2245616546NM_053965hhEST, Weakly similar tocarnitine/acylcarnitine translocase;mitochondrial carnitine-acylcarnitinetranslocase gene [Mus musculus][M. musculus], ESTs, Weakly similar tosolute carrier family 25(carnitine/acylcarnitine translocase),member 20 [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar toMCAT_HUMAN MITOCHONDRIALCARNITINE/ACYLCARNITINECARRIER PROTEIN [H. sapiens], Homosapiens, similar to solute carrier family25 (carnitine/acylcarnitine translocase),member 20, clone MGC: 35539IMAGE: 5200129, mRNA, complete cds,Mus musculus ,Similar to CG4995 geneproduct, clone MGC: 7958IMAGE: 3584570, mRNA, complete cds,expressed sequence AW491445,expressed sequence W51672, ornithinetransporter 2, solute carrier family 25(carnitine/acylcarnitine translocase),member 20, solute carrier family 25(mitochondrial carnitine/acylcarnitinetranslocase), member 20, solute carrierfamily 25 (mitochondrial carrier; adeninenucleotide translocator), member 3,solute carrier family 25 (mitochondrialcarrier; ornithine transporter) member 15245616547NM_053965hhEST, Weakly similar tocarnitine/acylcarnitine translocase;mitochondrial carnitine-acylcarnitinetranslocase gene [Mus musculus][M. musculus], ESTs, Weakly similar tosolute carrier family 25(carnitine/acylcarnitine translocase),member 20 [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar toMCAT_HUMAN MITOCHONDRIALCARNITINE/ACYLCARNITINECARRIER PROTEIN [H. sapiens], Homosapiens, similar to solute carrier family25 (carnitine/acylcarnitine translocase),member 20, clone MGC: 35539IMAGE: 5200129, mRNA, complete cds,Mus musculus ,Similar to CG4995 geneproduct, clone MGC: 7958IMAGE: 3584570, mRNA, complete cds,expressed sequence AW491445,expressed sequence W51672, ornithinetransporter 2, solute carrier family 25(carnitine/acylcarnitine translocase),member 20, solute carrier family 25(mitochondrial carnitine/acylcarnitinetranslocase), member 20, solute carrierfamily 25 (mitochondrial carrier; adeninenucleotide translocator), member 3,solute carrier family 25 (mitochondrialcarrier; ornithine transporter) member 15240520902NM_053593rEST, Weakly similar to cyclin-dependentkinase 4 [Rattus norvegicus][R. norvegicus], ESTs, Moderately similarto cyclin-dependent kinase 4 [Rattusnorvegicus ][R. norvegicus], ESTs,Moderately similar to CDK4 MOUSECELL DIVISION PROTEIN KINASE 4[M. musculus], cyclin-dependent kinase4, cyclin-dependent kinase 63909254AA892470eEST, Weakly similar to histone H2A.F/Zvariant [Homo sapiens] [H. sapiens],ESTs, Weakly similar to H2AZ_HUMANHISTONE H2A [H. sapiens], H2A histonefamily, member Z, Homo sapiens cDNAFLJ32241 fis, clone PLACE6005231,RIKEN cDNA C530002L11 gene, histoneH2A.F/Z variant3916942AA799520eEST, Weakly similar to integralmembrane protein 2B [Homo sapiens][H. sapiens], integral membrane protein2B2072904NM_019620pEST, Weakly similar to Kruppelassociated box (KRAB) zinc finger 1[Rattus norvegicus] [R. norvegicus], EST,Weakly similar to ZINC FINGERPROTEIN 91 [H. sapiens], ESTs,Moderately similar to DNA-bindingprotein; zinc finger protein 253 [Homosapiens] [H. sapiens], ESTs, Moderatelysimilar to ZINC FINGER PROTEIN 91[H. sapiens], Mus musculus ,Similar toRIKEN cDNA 2610036F08 gene, cloneMGC: 28645 IMAGE: 4224834, mRNA,complete cds, expressed sequenceAI790734, expressed sequenceAU021768, zinc finger protein 386(Kruppel-like), zinc finger protein 91(HPF7, HTF10)264520810X14181f, g, w, xEST, Weakly similar to ribosomalprotein L18a; 60S ribosomal proteinL18a [Homo sapiens] [H. sapiens], ESTs,Highly similar to ribosomal protein L18a;60S ribosomal protein L18a [Homosapiens] [H. sapiens]35318269AA891769eEST, Weakly similar to SC65synaptonemal complex protein [Rattusnorvegicus ][R. norvegicus], ESTs,Weakly similar to SC65 synaptonemalcomplex protein [Rattus norvegicus][R. norvegicus], SC65 synaptonemalcomplex protein, cartilage associatedprotein, growth suppressor 1, nucleolarautoantigen (55 kD) similar to ratsynaptonemal complex protein146917AA012709bEST, Weakly similar to splicing factor3b, subunit 1, 155 kDa [Mus musculus][M. musculus], ESTs, Weakly similar toS3B1_HUMAN Splicing factor 3B subunit1 (Spliceosome associated protein 155)(SAP 155) (SF3b155) (Pre-mRNAsplicing factor SF3b 155 kDa subunit)[H. sapiens], splicing factor 3b, subunit 1,155 kDa, splicing factor 3b, subunit 1,155 kD136822691AI77967r, aa, bbEST, Weakly similar to transforminggrowth factor-beta (TGF-beta) maskingprotein large subunit [Rattus norvegicus][R. norvegicus], ESTs, Highly similar toFIBRILLIN 2 PRECURSOR[M. musculus], ESTs, Weakly similar toA57293 latent transforming growth factorbeta-binding protein 3 precursor - mouse[M. musculus], RIKEN cDNA2310046A13 gene, latent transforminggrowth factor beta binding protein 1,transforming growth factor-beta (TGF-beta) masking protein large subunit248718122NM_057208h, lEST, Weakly similar to tropomyosin 3,gamma [Rattus norvegicus][R. norvegicus], ESTs, Highly similar toTPMN_HUMAN TROPOMYOSIN,CYTOSKELETAL TYPE [H. sapiens],ESTs, Moderately similar toTROPOMYOSIN 5, CYTOSKELETALTYPE [M. musculus]245815135NM_053971h, l, n, o,EST, Weakly similar to 60Sw, xRIBOSOMAL PROTEIN L6[M. musculus], ESTs, Weakly similar to60S RIBOSOMAL PROTEIN L6[M. musculus], ribosomal protein L6245815136NM_053971h, l, w, iiEST, Weakly similar to 60SRIBOSOMAL PROTEIN L6[M. musculus], ESTs, Weakly similar to60S RIBOSOMAL PROTEIN L6[M. musculus], ribosomal protein L620022026AA850060n, oEST, Weakly similar to 810024L URF 5[H. sapiens], Homo sapiens cDNAFLJ10784 fis, clone NT2RP4000448,highly similar to Homo sapiens mRNA;cDNA DKFZp566G0746, RIKEN cDNA3830414F09 gene20022028AA850060cc, ddEST, Weakly similar to 810024L URF 5[H. sapiens], Homo sapiens cDNAFLJ10784 fis, clone NT2RP4000448,highly similar to Homo sapiens mRNA;cDNA DKFZp566G0746, RIKEN cDNA3830414F09 gene27816029AA874803j, kEST, Weakly similar to 810024L URF 5[H. sapiens], Homo sapiens cDNAFLJ10784 fis, clone NT2RP4000448,highly similar to Homo sapiens mRNA;cDNA DKFZp566G0746, RIKEN cDNA3830414F09 gene27816030AA874803j, kEST, Weakly similar to 810024L URF 5[H. sapiens], Homo sapiens cDNAFLJ10784 fis, clone NT2RP4000448,highly similar to Homo sapiens mRNA;cDNA DKFZp566G0746, RIKEN cDNA3830414F09 gene522030AI011177h, lEST, Weakly similar to 810024L URF 5[H. sapiens], Homo sapiens cDNAFLJ10784 fis, clone NT2RP4000448,highly similar to Homo sapiens mRNA;cDNA DKFZp566G0746, RIKEN cDNA3830414F09 gene25911760NM_147211d, kkEST, Weakly similar to A22940 keratin,67K type II cytoskeletal [H. sapiens],EST, Weakly similar to FORMIN 4[M. musculus], ESTs, Weakly similar toFMN2_MOUSE Formin 2 [M. musculus],ESTs, Weakly similar to FORMIN 4[M. musculus], ESTs, Weakly similar toLORI MOUSE LORICRIN [M. musculus],RIKEN cDNA A330103N21 gene,expressed sequence AI854843,expressed sequence AW742646, formin2, hypothetical protein BC012775,hypothetical protein FLJ20584, similar toWiskott-Aldrich syndrome proteininteracting protein, uridine-cytidinekinase 122151540NM_031012nEST, Weakly similar to A32852membrane alanyl aminopeptidase (EC3.4.11.2) - rat [R. norvegicus], ESTs,Weakly similar to AMPN MOUSEAMINOPEPTIDASE N [M. musculus],RIKEN cDNA 2010111I01 gene, RIKENcDNA 4833403I15 gene, alanyl(membrane) aminopeptidase, alanyl(membrane) aminopeptidase(aminopeptidase N, aminopeptidase M,microsomal aminopeptidase, CD13,p150)18631529NM_013082hhEST, Weakly similar to A33880syndecan 2 [H. sapiens], Mus musculus,clone IMAGE: 4983756, mRNA, partialcds, syndecan 2, syndecan 2 (heparansulfate proteoglycan 1, cell surface-associated, fibroglycan)64617540AA955914aEST, Weakly similar to A38712 fibrillarin[H. sapiens], EST, Weakly similar toFBRL MOUSE FIBRILLARIN[M. musculus], ESTs, Moderately similarto FIBRILLARIN [M. musculus],expressed sequence AL022665,fibrillarin124822432AI171263a, zEST, Weakly similar to A38712 fibrillarin[H. sapiens], ESTs, Moderately similar toFIBRILLARIN [M. musculus], fibrillarin219713633NM_024403e, p, q, y, zEST, Weakly similar to A45377transcription factor ATF4 [H. sapiens],ESTs, Highly similar to A45377transcription factor ATF4 [H. sapiens],activating transcription factor 4,activating transcription factor 4 (tax-responsive enhancer element B67),activating transcription factor 5219713634NM_024403a, j, k, p,EST, Weakly similar to A45377q, y, ztranscription factor ATF4 [H. sapiens],ESTs, Highly similar to A45377transcription factor ATF4 [H. sapiens],activating transcription factor 4,activating transcription factor 4 (tax-responsive enhancer element B67),activating transcription factor 524072103NM_053597gEST, Weakly similar to A48045ribosomal protein S27, cytosolic[H. sapiens], ESTs, Highly similar toA48045 ribosomal protein S27, cytosolic[H. sapiens], ribosomal protein S27(metallopanstimulin 1), ribosomal proteinS27-like22783292NM_031531a, j, kEST, Weakly similar to AACT_HUMANALPHA-1-ANTICHYMOTRYPSINPRECURSOR [H. sapiens], RIKEN cDNA4833409F13 gene, serine proteaseinhibitor 2-2171917145M38566ggEST, Weakly similar to AACT_HUMANALPHA-1-ANTICHYMOTRYPSINPRECURSOR [H. sapiens], serine (orcysteine) proteinase inhibitor, clade F(alpha-2 antiplasmin, pigment epitheliumderived factor), member 2, serineprotease inhibitor 2-2268917146Y07534aaEST, Weakly similar to AACT_HUMANALPHA-1-ANTICHYMOTRYPSINPRECURSOR [H. sapiens], serine (orcysteine) proteinase inhibitor, clade F(alpha-2 antiplasmin, pigment epitheliumderived factor), member 2, serineprotease inhibitor 2-293222614AI031004tEST, Weakly similar to B36298 proline-rich protein PRB3S [H. sapiens], EST,Weakly similar to CGHU3B collagenalpha 3(IV) chain precursor, long spliceform [H. sapiens], EST, Weakly similar toD40750 proline-rich protein PRB1/2S[H. sapiens], EST, Weakly similar toPIHUB6 salivary proline-rich proteinprecursor PRB1 [H. sapiens], EST,Weakly similar to PRP1_HUMANSALIVARY PROLINE-RICH PROTEINPRECURSOR [H. sapiens], Musmusculus adult male tongue cDNA,RIKEN full-length enriched library,clone: 2310039K21: SRY-box containinggene 7, full insert sequence, SRY (sexdetermining region Y)-box 17, SRY (sexdetermining region Y)-box 18, SRY (sexdetermining region Y)-box 7, SRY-boxcontaining gene 175417380AA799612w, xEST, Weakly similar to B41222 ubiquitin-protein ligase [H. sapiens], ESTs, Highlysimilar to ubiquitin conjugating enzyme[Rattus norvegicus] [R. norvegicus],ESTs, Highly similar to A41222 ubiquitin-protein ligase [H. sapiens], ESTs,Moderately similar to B41222 ubiquitin-protein ligase [H. sapiens], ESTs, Weaklysimilar to UBC2_HUMAN UBIQUITIN-CONJUGATING ENZYME E2-17 KD[M. musculus], RIKEN cDNA2610301N02 gene, expressed sequenceAI327276, ubiquitin-conjugating enzymeE2A (RAD6 homolog), ubiquitin-conjugating enzyme E2A, RAD6homolog (S. cerevisiae), ubiquitin-conjugating enzyme E2B (RAD6homolog), ubiquitin-conjugating enzymeE2B, RAD6 homology (S. cerevisiae),ubiquitin-conjugating enzyme E2C225817379NM_031138r, w, xEST, Weakly similar to B41222 ubiquitin-protein ligase [H. sapiens], ESTs, Highlysimilar to ubiquitin conjugating enzyme[Rattus norvegicus] [R. norvegicus],ESTs, Highly similar to A41222 ubiquitin-protein ligase [H. sapiens], ESTs,Moderately similar to B41222 ubiquitin-protein ligase [H. sapiens], ESTs, Weaklysimilar to UBC2_HUMAN UBIQUITIN-CONJUGATING ENZYME E2-17 KD[M. musculus], RIKEN cDNA2610301N02 gene, expressed sequenceAI327276, ubiquitin-conjugating enzymeE2A (RAD6 homolog), ubiquitin-conjugating enzyme E2A, RAD6homolog (S. cerevisiae), ubiquitin-conjugating enzyme E2B (RAD6homolog), ubiquitin-conjugating enzymeE2B, RAD6 homology (S. cerevisiae),ubiquitin-conjugating enzyme E2C64823357AA956114cc, ddEST, Weakly similar to B41222 ubiquitin-protein ligase [H. sapiens], ESTs, Highlysimilar to A41222 ubiquitin—proteinligase [H. sapiens], ESTs, Weakly similarto UBC2_HUMAN UBIQUITIN-CONJUGATING ENZYME E2-17 KD[M. musculus], RIKEN cDNA2610301N02 gene, expressed sequenceAI327276, ubiquitin conjugating enzyme,ubiquitin-conjugating enzyme E2A(RAD6 homolog), ubiquitin-conjugatingenzyme E2A, RAD6 homolog (S.cerevisiae), ubiquitin-conjugatingenzyme E2B (RAD6 homolog), ubiquitin-conjugating enzyme E2B, RAD6homology (S. cerevisiae), ubiquitin-conjugating enzyme E2C8854253AI013566jj, kkEST, Weakly similar to beta-fibrinogenprecursor [H. sapiens], ESTs, Moderatelysimilar to ANL2_MOUSE Angiopoietin-related protein 2 precursor (Angiopoietin-like 2) [M. musculus], Mus musculus,Similar to angiopoietin-related protein 5,clone MGC: 32467 IMAGE: 5049765,mRNA, complete cds, Mus musculus,Similar to fibrinogen-like 1, cloneMGC: 37822 IMAGE: 5098805, mRNA,complete cds, Rattus norvegicusSprague-Dawley fibrinogen B beta chainmRNA, complete cds, angiopoietin-like2, angiopoietin-related protein 5,expressed sequence AI593246,hypothetical protein FLJ11286146122484AI230591llEST, Weakly similar to CATM_HUMANCATHEPSIN L2 PRECURSOR(CATHEPSIN V) (CATHEPSIN U)[H. sapiens], EST, Weakly similar toTES1_RAT TESTIN 1/2 PRECURSOR(CMB-22/CMB-23) [R. norvegicus],RIKEN cDNA 4930486L24 gene, Rattusnorvegicus testin mRNA, complete cds,cytotoxic T lymphocyte-associatedprotein 2 alpha9832662AI045686eEST, Weakly similar to CBP MOUSECREB-BINDING PROTEIN[M. musculus], ESTs, Highly similar toBRD4_HUMAN BROMODOMAIN-CONTAINING PROTEIN 4 (HUNK1PROTEIN) [H. sapiens], ESTs, Highlysimilar to CBP MOUSE CREB-BINDINGPROTEIN [M. musculus], ESTs,Moderately similar to CBP MOUSECREB-BINDING PROTEIN[M. musculus], ESTs, Weakly similar toCBP MOUSE CREB-BINDING PROTEIN[M. musculus], bromodomain-containing 47919746AI009555rEST, Weakly similar to DYJ2_HUMANDYNEIN LIGHT INTERMEDIATE CHAIN2, CYTOSOLIC [H. sapiens], LIC-2dynein light intermediate chain 53/55,RIKEN cDNA 1110053F02 gene, dyneinlight chain-A, dynein, cytoplasmic, lightintermediate polypeptide 2, expressedsequence AA409702221916210NM_031026l, mEST, Weakly similar to DYJ2_HUMANDYNEIN LIGHT INTERMEDIATE CHAIN2, CYTOSOLIC [H. sapiens], RIKENcDNA 1110053F02 gene, Rattusnorvegicus dynein light intermediatechain 1 mRNA, complete cds, dyneinlight chain-A, dynein, cytoplasmic, lightintermediate polypeptide 2, expressedsequence AA409702234117734NM_031970a, o, q,EST, Weakly similar to HHHU27 heatee, ff, kkshock protein 27 [H. sapiens], ESTs,Highly similar to HHHU27 heat shockprotein 27 [H. sapiens], ESTs, Moderatelysimilar to HHHU27 heat shock protein 27[H. sapiens], heat shock 27 kD protein 1,hypothetical protein MGC10974234117735NM_031970a, z, ee,EST, Weakly similar to HHHU27 heatff, kkshock protein 27 [H. sapiens], ESTs,Highly similar to HHHU27 heat shockprotein 27 [H. sapiens], ESTs, Moderatelysimilar to HHHU27 heat shock protein 27[H. sapiens], heat shock 27 kD protein 1,hypothetical protein MGC10974234117736NM_031970a, l, o, q,EST, Weakly similar to HHHU27 heatee, ff, kkshock protein 27 [H. sapiens], ESTs,Highly similar to HHHU27 heat shockprotein 27 [H. sapiens], ESTs, Moderatelysimilar to HHHU27 heat shock protein 27[H. sapiens], heat shock 27 kD protein 1,hypothetical protein MGC10974243315615NM_053800h, lEST, Weakly similar to HumanThioredoxin [H. sapiens], RIKEN cDNA4930429J24 gene, thioredoxin,thioredoxin 1209317100NM_022179h, l, w, x,EST, Weakly similar to HXK2 MOUSEddHEXOKINASE TYPE II [M. musculus],ESTs, Moderately similar toHXK3_HUMAN HEXOKINASE TYPE III[H. sapiens], ESTs, Weakly similar toHXK2 MOUSE HEXOKINASE TYPE II[M. musculus], hexokinase 2, hexokinase3 (white cell)211423705NM_022396e, j, k, iiEST, Weakly similar to I39159 GTP-binding regulatory protein gamma-11chain [H. sapiens], ESTs, Moderatelysimilar to GBGB_HUMAN Guaninenucleotide-binding proteinG(I)/G(S)/G(O) gamma-11 subunit[R. norvegicus], ESTs, Weakly similar toGBGB_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit [R. norvegicus], RIKEN cDNA0610037B21 gene, guanine nucleotidebinding protein (G protein), gamma 1subunit, guanine nucleotide bindingprotein (G protein), gamma transducingactivity polypeptide 1, guaninenucleotide binding protein (G protein),gamma transducing activity polypeptide2, guanine nucleotide binding protein 11201320232NM_017364u, vEST, Weakly similar to I49636 DNA-binding protein - mouse [M. musculus],ESTs, Highly similar to OZF_HUMANZINC FINGER PROTEIN OZF[H. sapiens], ESTs, Weakly similar toOZF MOUSE ZINC FINGER PROTEINOZF [M. musculus], ESTs, Weakly similarto OZF_HUMAN ZINC FINGERPROTEIN OZF [H. sapiens], Musmusculus, clone MGC: 37070IMAGE: 4951074, mRNA, complete cds,RIKEN cDNA 2810039B14 gene, RIKENcDNA 2810054M15 gene, zinc fingerprotein 146, zinc finger protein 260, zincfinger protein 63157322212AI236294kkEST, Weakly similar to IF6_HUMANEUKARYOTIC TRANSLATIONINITIATION FACTOR 6 [H. sapiens],ESTs, Highly similar to IF6_HUMANEUKARYOTIC TRANSLATIONINITIATION FACTOR 6 [H. sapiens], Musmusculus 10 days neonate cerebellumcDNA, RIKEN full-length enriched library,clone: 6530402L05: integrin beta 4binding protein, full insert sequence,integrin beta 4 binding protein11817414AI137586aEST, Weakly similar to IMB3_HUMANIMPORTIN BETA-3 SUBUNIT[H. sapiens], Homo sapiens cDNAFLJ12978 fis, clone NT2RP2006321,RAN binding protein 6, importin 4159111208AI237586kkEST, Weakly similar to JC1241 beta-interferon-induced protein - rat[R. norvegicus], ESTs, Moderately similarto JC1241 beta-interferon-inducedprotein - rat [R. norvegicus], Musmusculus, clone MGC: 31632IMAGE: 4511454, mRNA, complete cds,RIKEN cDNA 1110036C17 gene,interferon induced transmembraneprotein 2 (1-8D)58819480AA944442r, bbEST, Weakly similar to JC2324 LIMprotein [H. sapiens], ESTs, Weaklysimilar to JG0164 LIM protein, FHL4 -mouse [M. musculus], Homo sapienscDNA FLJ13238 fis, cloneOVARC1000440, Homo sapiens cDNAFLJ31627 fis, clone NT2RI2003338,RIKEN cDNA 2410002J21 gene,activator of cAMP-responsive elementmodulator (CREM) in testis, expressedsequence AI481106, expressedsequence AV278559, expressedsequence AW123232, hypotheticalprotein FLJ10044, paxillin, testis derivedtranscript (3 LIM domains), transforminggrowth factor beta 1 induced transcript 15820092AA799637r, llEST, Weakly similar to JC2324 LIMprotein [H. sapiens], Homo sapiens cDNAFLJ13238 fis, clone OVARC1000440,RIKEN cDNA 2410002J21 gene,expressed sequence AV278559,expressed sequence AW123232,hypothetical protein FLJ10044, paxillin,transforming growth factor beta 1induced transcript 1222825600NM_031077b, l, mEST, Weakly similar to JC5111 cyclin-dependent kinase-related protein 1b - rat[R. norvegicus], EST, Weakly similar toS10889 proline-rich protein [H. sapiens],ESTs, Highly similar to KPT1 MOUSESERINE/THREONINE-PROTEINKINASE PCTAIRE-1 [M. musculus],ESTs, Weakly similar to KPT1 MOUSESERINE/THREONINE-PROTEINKINASE PCTAIRE-1 [M. musculus],PCTAIRE protein kinase 1, PCTAIRE-motif protein kinase 122286349NM_031077ee, ffEST, Weakly similar to JC5111 cyclin-dependent kinase-related protein 1b - rat[R. norvegicus], EST, Weakly similar toS10889 proline-rich protein [H. sapiens],ESTs, Highly similar to KPT1 MOUSESERINE/THREONINE-PROTEINKINASE PCTAIRE-1 [M. musculus],ESTs, Weakly similar to KPT1 MOUSESERINE/THREONINE-PROTEINKINASE PCTAIRE-1 [M. musculus],PCTAIRE protein kinase 1, PCTAIRE-motif protein kinase 1257521818NM_139342bbEST, Weakly similar to JC5399 dualleucine zipper kinase (EC 2.7.—.—) - rat[R. norvegicus], ESTs, Highly similar toA55318 serine/threonine protein kinase[M. musculus], ESTs, Weakly similar toJC5399 dual leucine zipper kinase (EC2.7.—.—) - rat [R. norvegicus], ankyrinrepeat domain 3, expressed sequenceC81508, receptor (TNFRSF)-interactingserine-threonine kinase 1188124867NM_013155kkEST, Weakly similar to LDVR_RAT Verylow-density lipoprotein receptorprecursor (VLDL receptor)[R. norvegicus], ESTs, Weakly similar toLDVR MOUSE VERY LOW-DENSITYLIPOPROTEIN RECEPTORPRECURSOR [M. musculus], ESTs,Weakly similar to LDVR_RAT Very low-density lipoprotein receptor precursor(VLDL receptor) [R. norvegicus], lowdensity lipoprotein receptor-relatedprotein 8, apolipoprotein e receptor, verylow density lipoprotein receptor31624470AA875523aa, bbEST, Weakly similar to MOHU6N myosinalkali light chain 6, nonmuscle form[H. sapiens], myosin light chain, alkali,nonmuscle, myosin, light polypeptide 6,alkali, smooth muscle and non-muscle31624471AA875523iiEST, Weakly similar to MOHU6N myosinalkali light chain 6, nonmuscle form[H. sapiens], myosin light chain, alkali,nonmuscle, myosin, light polypeptide 6,alkali, smooth muscle and non-muscle31624472AA875523iiEST, Weakly similar to MOHU6N myosinalkali light chain 6, nonmuscle form[H. sapiens], myosin light chain, alkali,nonmuscle, myosin, light polypeptide 6,alkali, smooth muscle and non-muscle46424473AA894200bEST, Weakly similar to MOHU6N myosinalkali light chain 6, nonmuscle form[H. sapiens], myosin light chain, alkali,nonmuscle, myosin, light polypeptide 6,alkali, smooth muscle and non-muscle260624469S77858llEST, Weakly similar to MOHU6N myosinalkali light chain 6, nonmuscle form[H. sapiens], myosin light chain, alkali,nonmuscle, myosin, light polypeptide 6,alkali, smooth muscle and non-muscle263317296U76206jj, kkEST, Weakly similar to P2YX_RAT UDP-glucose receptor (G protein-coupledreceptor GPR105) (VTR 15-20)[R. norvegicus], ESTs, Weakly similar toGPRY_MOUSE PROBABLE GPROTEIN-COUPLED RECEPTORGPR34 [M. musculus], ESTs, Weaklysimilar to P2YX_RAT UDP-glucosereceptor (G protein-coupled receptorGPR105) (VTR 15-20) [R. norvegicus], Gprotein-coupled receptor 105, G protein-coupled receptor 34, G protein-coupledreceptor 86, G protein-coupled receptor87, Purinergic receptor P2Y, G protein-coupled, 12, platelet activating receptorhomolog21232109NM_022511n, o, w, xEST, Weakly similar to PRO1 MOUSEPROFILIN I [M. musculus], EST, Weaklysimilar to PRO2_HUMAN PROFILIN II[H. sapiens], ESTs, Weakly similar toPRO2_HUMAN PROFILIN II [H. sapiens],Mk1 protein, profilin 123572577NM_033236rEST, Weakly similar to PRS7 MOUSE26S PROTEASE REGULATORYSUBUNIT 7 [M. musculus], RIKEN cDNA2300001E01 gene, proteasome(prosome, macropain) 26S subunit,ATPase 2, syntaxin 822631291NM_031149c, rEST, Weakly similar to PRS8 MOUSE26S PROTEASE REGULATORYSUBUNIT 8 [M. musculus], Homosapiens mRNA; cDNA DKFZp586I1420(from clone DKFZp586I1420); partialcds, YME1-like 1 (S. cerevisiae),hypothetical protein DKFZp667C165,protease (prosome, macropain) 26Ssubunit, ATPase 5, proteasome(prosome, macropain) 26S subunit,ATPase, 5, proteasome (prosome,macropain) 26S subunit, ATPase, 660624521AA945636g, h, lEST, Weakly similar to R6HUP1 acidicribosomal protein P1, cytosolic[H. sapiens], ESTs, Highly similar toR6HUP1 acidic ribosomal protein P1,cytosolic [H. sapiens], ESTs, Weaklysimilar to RLA1 MOUSE 60S ACIDICRIBOSOMAL PROTEIN P1[M. musculus], expressed sequenceAI255964, ribosomal protein, large, P1223215201NM_031093h, l, wEST, Weakly similar to RALA MOUSERAS-RELATED PROTEIN RAL-A[M. musculus], ESTs, Weakly similar toCrystal Structure Of The Small G ProteinRap2a With Gdp {SUB 1-167[H. sapiens], ESTs, Weakly similar toRALA MOUSE RAS-RELATEDPROTEIN RAL-A [M. musculus], v-ralsimian leukemia viral oncogene homologA (ras related)223215202NM_031093f, w, x,EST, Weakly similar to RALA MOUSEcc, ddRAS-RELATED PROTEIN RAL-A[M. musculus], ESTs, Weakly similar toCrystal Structure Of The Small G ProteinRap2a With Gdp {SUB 1-167[H. sapiens], ESTs, Weakly similar toRALA MOUSE RAS-RELATEDPROTEIN RAL-A [M. musculus], v-ralsimian leukemia viral oncogene homologA (ras related)223215203NM_031093aa, bbEST, Weakly similar to RALA MOUSERAS-RELATED PROTEIN RAL-A[M. musculus], ESTs, Weakly similar toCrystal Structure Of The Small G ProteinRap2a With Gdp {SUB 1-167[H. sapiens], ESTs, Weakly similar toRALA MOUSE RAS-RELATEDPROTEIN RAL-A [M. musculus], v-ralsimian leukemia viral oncogene homologA (ras related)120011337AI145968l, mEST, Weakly similar to RB6K MOUSERABKINESIN-6 [M. musculus], ESTs,Weakly similar to RB6K MOUSERABKINESIN-6 [M. musculus], RAB6interacting, kinesin-like (rabkinesin6),Rab6, kinesin-like265418606X53504g, w, xEST, Weakly similar to RL12_HUMAN60S RIBOSOMAL PROTEIN L12[H. sapiens], ESTs, Weakly similar toRL12_HUMAN 60S RIBOSOMALPROTEIN L12 [H. sapiens], ribosomalprotein L12264719244X15013f, g, w, xEST, Weakly similar to RL7A MOUSE60S RIBOSOMAL PROTEIN L7A[M. musculus], RIKEN cDNA4632404N19 gene, ribosomal proteinL7a224310878NM_031110g, j, kEST, Weakly similar to RS11_HUMAN40S ribosomal protein S11[R. norvegicus], Homo sapiens mRNA;cDNA DKFZp434A0326 (from cloneDKFZp434A0326), RAD21 homolog (S.pombe), ribosomal protein S11236224419NM_033539jj, kkEST, Weakly similar to S21055translation elongation factor eEF-1 alphachain - rat [R. norvegicus], ESTs, Highlysimilar to EFHU1 translation elongationfactor eEF-1 alpha-1 chain [H. sapiens],ESTs, Weakly similar to S21055translation elongation factor eEF-1 alphachain - rat [R. norvegicus], G1 to S phasetransition 1, G1 to phase transition 1, G1to phase transition 2, eukaryotictranslation elongation factor 1 alpha 1142213673AI227763ggEST, Weakly similar to S26650 DNA-binding protein 5 [H. sapiens], ESTs,Weakly similar to S26650 DNA-bindingprotein 5 [H. sapiens], hypotheticalprotein dJ465N24.2.1, protamine 1109916596AI102486ee, ff, kkEST, Weakly similar to S37583 RINGfinger protein rfp - mouse [M. musculus],RIKEN cDNA 1810012B10 gene,expressed sequence AW538890,hypothetical gene MGC1127125316599AI171366ee, ff, jj,EST, Weakly similar to S37583 RINGkkfinger protein rfp - mouse [M. musculus],RIKEN cDNA 1810012B10 gene,expressed sequence AW538890,hypothetical gene MGC112743321652AA893267u, vEST, Weakly similar to S46992 proteinp130 - rat [R. norvegicus], ESTs, Weaklysimilar to A59300 myosin-If - mouse[M. musculus], ESTs, Weakly similar toCASL MOUSE ENHANCER OFFILMENTATION 1 [M. musculus], RIKENcDNA 4631403P03 gene, RIKEN cDNA9130023P14 gene, RIKEN cDNAC330006B10 gene, embryonal Fyn-associated substrate, myosin If,peroxisomal biogenesis factor 13, prolineserine-threonine phosphatase interactingprotein 1121311550AI169591rEST, Weakly similar to S57447 HPBRII-7 protein [H. sapiens], cleavage andpolyadenylation specific factor 6, 68 kDsubunit, hypothetical protein FLJ12529110011953AI102505hhEST, Weakly similar to S71929cytochrome-c oxidase (EC 1.9.3.1) chainVIII precursor, hepatic - mouse[M. musculus], cytochrome c oxidase,subunit VIIIa, heme-regulated initiationfactor 2-alpha kinase110011954AI102505hhEST, Weakly similar to S71929cytochrome-c oxidase (EC 1.9.3.1) chainVIII precursor, hepatic - mouse[M. musculus], cytochrome c oxidase,subunit VIIIa, heme-regulated initiationfactor 2-alpha kinase170311955L48209hhEST, Weakly similar to S71929cytochrome-c oxidase (EC 1.9.3.1) chainVIII precursor, hepatic - mouse[M. musculus], cytochrome C oxidase,subunit VIIIa, heme-regulated initiationfactor 2-alpha kinase21358097NM_022536h, lEST, Weakly similar to secretedcyclophilin-like protein [H. sapiens],ESTs, Weakly similar to cyclophilin B[Rattus norvegicus] [R. norvegicus],RIKEN cDNA 3732410E19 gene,peptidylprolyl isomerase (cyclophilin)-like1, peptidylprolyl isomerase B,peptidylprolyl isomerase B (cyclophilinB), peptidylprolyl isomerase C,peptidylprolyl isomerase C (cyclophilinC)21358098NM_022536iiEST, Weakly similar to secretedcyclophilin-like protein [H. sapiens],ESTs, Weakly similar to cyclophilin B[Rattus norvegicus] [R. norvegicus],RIKEN cDNA 3732410E19 gene,peptidylprolyl isomerase (cyclophilin)-like1, peptidylprolyl isomerase B,peptidylprolyl isomerase B (cyclophilinB), peptidylprolyl isomerase C,peptidylprolyl isomerase C (cyclophilinC)13766502AI178283rEST, Weakly similar to SYFB_MOUSEPHENYLALANYL-TRNA SYNTHETASEBETA CHAIN (PHENYLALANINE - TRNALIGASE BETA CHAIN) (PHERS)[M. musculus], Homo sapiens cDNAFLJ30727 fis, clone FEBRA2000007,highly similar to Homo sapiens putativephenylalanyl-tRNA synthetase beta-subunit mRNA, KIAA1185 protein,RIKEN cDNA 2900010D03 gene,expressed sequence C76708,phenylalanine-tRNA synthetase-like,phenylalanyl-tRNA synthetase beta-subunit7382526AA998979u, vEST, Weakly similar to T00051hypothetical protein KIAA0404[H. sapiens], Homo sapiens, cloneIMAGE: 4657824, mRNA, KIAA0404protein, hypothetical protein FLJ1024286123025AI012621j, kEST, Weakly similar to T00357hypothetical protein KIAA0685[H. sapiens], Homo sapiens mRNA forKIAA1558 protein, partial cds, KIAA0685gene product, KIAA1115 protein,chromosome 11 open reading frame 2383224022AI011474a, ee, ff,EST, Weakly similar to T00637llhypothetical protein H_GS541B18.1[H. sapiens], golgi phosphoprotein 243622355AA893338b, u, vEST, Weakly similar to T12456hypothetical protein DKFZp564M2423.1[H. sapiens], ESTs, Highly similar toT12456 hypothetical proteinDKFZp564M2423.1 [H. sapiens], PAI-1mRNA-binding protein, RIKEN cDNA1200009K13 gene, intracellularhyaluronan-binding protein9687992AI044845cc, dd,EST, Weakly similar to T12482gghypothetical protein DKFZp564P0662.1[H. sapiens], ESTs, Weakly similar toT12482 hypothetical proteinDKFZp564P0662.1 [H. sapiens], Homosapiens cDNA FLJ32000 fis, cloneNT2RP7009370, weakly similar toPUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC 2.7.1.—),echinoderm microtubule associatedprotein like 213736059AI178245cEST, Weakly similar to T13963 forminrelated protein, lymphocyte specific -mouse [M. musculus], ESTs, Highlysimilar to T13963 formin related protein,lymphocyte specific - mouse[M. musculus], ESTs, Moderately similarto T13963 formin related protein,lymphocyte specific - mouse[M. musculus], Homo sapiens mRNA;cDNA DKFZp762B245 (from cloneDKFZp762B245); partial cds, forminhomology 2 domain containing 1, formin-like282882AA799423llEST, Weakly similar to T42637hypothetical protein 162K - mouse[M. musculus], ESTs, Highly similar toMYH9_RAT Myosin heavy chain,nonmuscle type A (Cellular myosinheavy chain, type A) (Nonmuscle myosinheavy chain-A) (NMMHC-A)[R. norvegicus], ESTs, Weakly similar toMYH9_RAT Myosin heavy chain,nonmuscle type A (Cellular myosinheavy chain, type A) (Nonmuscle myosinheavy chain-A) (NMMHC-A)[R. norvegicus], Mus musculus ,cloneMGC: 7530 IMAGE: 3492114, mRNA,complete cds, Myosin, heavypolypeptide 9, non-muscle, RIKEN cDNA3110050K21 gene, eukaryotic translationinitiation factor 3, myosin heavy chain IX,myosin, heavy polypeptide 9, non-muscle, nasopharyngeal epitheliumspecific protein 17512881AF056034b, d, u, vEST, Weakly similar to T42637hypothetical protein 162K - mouse[M. musculus], ESTs, Highly similar toMYH9_RAT Myosin heavy chain,nonmuscle type A (Cellular myosinheavy chain, type A) (Nonmuscle myosinheavy chain-A) (NMMHC-A)[R. norvegicus], ESTs, Weakly similar toMYH9_RAT Myosin heavy chain,nonmuscle type A (Cellular myosinheavy chain, type A) (Nonmuscle myosinheavy chain-A) (NMMHC-A)[R. norvegicus], Mus musculus ,cloneMGC: 7530 IMAGE: 3492114, mRNA,complete cds, Myosin, heavypolypeptide 9, non-muscle, RIKEN cDNA3110050K21 gene, eukaryotic translationinitiation factor 3, myosin heavy chain IX,myosin, heavy polypeptide 9, non-muscle, nasopharyngeal epitheliumspecific protein 1246816566NM_054004hhEST, Weakly similar to T42735 TBP-interacting protein TIP120 - rat[R. norvegicus], Homo sapiens cDNAFLJ14877 fis, clone PLACE1003044,TBP-interacting protein, expressedsequence AI195005168617159J00797w, x, aa,EST, Weakly similar to TBA1 MOUSEbb, hh, llTUBULIN ALPHA-1 CHAIN[M. musculus], tubulin, alpha 1, tubulin,alpha 2, tubulin, alpha 3, tubulin, alpha6, tubulin, alpha 7, tubulin, alpha,ubiquitous210517158NM_022298f, s, tEST, Weakly similar to TBA1 MOUSETUBULIN ALPHA-1 CHAIN[M. musculus], tubulin, alpha 1, tubulin,alpha 2, tubulin, alpha 3, tubulin, alpha6, tubulin, alpha 7, tubulin, alpha,ubiquitous210517160NM_022298b, l, m,EST, Weakly similar to TBA1 MOUSEaaTUBULIN ALPHA-1 CHAIN[M. musculus], tubulin, alpha 1, tubulin,alpha 2, tubulin, alpha 3, tubulin, alpha6, tubulin, alpha 7, tubulin, alpha,ubiquitous210517161NM_022298a, z, kkEST, Weakly similar to TBA1 MOUSETUBULIN ALPHA-1 CHAIN[M. musculus], tubulin, alpha 1, tubulin,alpha 2, tubulin, alpha 3, tubulin, alpha6, tubulin, alpha 7, tubulin, alpha,ubiquitous26513974AA860030n, o, w,EST, Weakly similar to TBB5 MOUSEx, llTUBULIN BETA-5 CHAIN [M. musculus],RIKEN cDNA 2310061K05 gene, RIKENcDNA 2410129E14 gene, RIKEN cDNA4930542G03 gene, tubulin, beta 5,tubulin, beta polypeptide, tubulin, beta,2, tubulin, beta, 5144413977AI229707rEST, Weakly similar to TBB5 MOUSETUBULIN BETA-5 CHAIN [M. musculus],RIKEN cDNA 2310061K05 gene, RIKENcDNA 2410129E14 gene, RIKEN cDNA4930542G03 gene, tubulin, beta 5,tubulin, beta polypeptide, tubulin, beta,2, tubulin, beta, 510469604AI071230ee, ff, ggEST, Weakly similar to TESTIN 2[M. musculus], Homo sapiens cDNAFLJ31627 fis, clone NT2RI2003338,Homo sapiens cDNA FLJ31929 fis, cloneNT2RP7006160226615273NM_031237aa, bbEST, Weakly similar to UB5C_HUMANUbiquitin-conjugating enzyme E2-17 kDa3 (Ubiquitin-protein ligase) (Ubiquitincarrier protein) (E2(17)KB 3)[R. norvegicus], ESTs, Weakly similar toS53358 ubiquitin-conjugating enzymeE2.17 kB - rat [R. norvegicus], Homosapiens EST from clone 37208, fullinsert, RIKEN cDNA 1100001F19 gene,RIKEN cDNA 1600028I17 gene,prefoldin 5, ubiquitin-conjugating enzymeE2D 3 (UBC4/5 homolog, yeast)226615277NM_031237aEST, Weakly similar to UB5C_HUMANUbiquitin-conjugating enzyme E2-17 kDa3 (Ubiquitin-protein ligase) (Ubiquitincarrier protein) (E2(17)KB 3)[R. norvegicus], ESTs, Weakly similar toS53358 ubiquitin-conjugating enzymeE2.17 kB - rat [R. norvegicus], Homosapiens EST from clone 37208, fullinsert, RIKEN cDNA 1100001F19 gene,RIKEN cDNA 1600028I17 gene,prefoldin 5, ubiquitin-conjugating enzymeE2D 3 (UBC4/5 homolog, yeast)129217679AI175025hhEST, Weakly similar to WS3_HUMANWS-3 PROTEIN [H. sapiens], novel RGD-containing protein117415969AI137302cc, ddEST, Weakly similar to ZF37_RAT Zincfinger protein 37 (Zfp-37) [R. norvegicus],ESTs, Weakly similar to ZF29 MOUSEZINC FINGER PROTEIN 29[M. musculus], ESTs, Weakly similar toZF93_MOUSE ZINC FINGER PROTEIN93 (ZFP-93) [M. musculus], expressedsequence AW557864, zinc finger protein29, zinc finger protein 37, zinc fingerprotein 37 homolog (mouse)22341295NM_031097j, k, rESTs, Highly similar to aminopeptidaseB [Rattus norvegicus] [R. norvegicus],Mus musculus, Similar toaminopeptidase B, clone MGC: 29229IMAGE: 5041005, mRNA, complete cds,RIKEN cDNA 2010111I01 gene,expressed sequence AI894167,hypothetical protein FLJ14675,leukotriene A4 hydrolase130218507AI175551h, l, w, x,ESTs, Highly similar to eukaryotickktranslation elongation factor 1 beta 2;eukaryotic translation elongation factor 1beta 1 [Homo sapiens] [H. sapiens],eukaryotic translation elongation factor 1beta 225485283NM_138535ggESTs, Highly similar to Glutamatereceptor interacting protein [Rattusnorvegicus] [R. norvegicus], Glutamatereceptor interacting protein, RIKENcDNA 4931400F03 gene, channel-interacting PDZ domain protein, multiplePDZ domain protein, syntrophin, alpha 1(dystrophin-associated protein A1, 59 kD,acidic component)3815303AA799518w, xESTs, Highly similar to hypotheticalprotein FLJ13725; KIAA1930 protein[Homo sapiens] [H. sapiens]4317599AA799539cESTs, Highly similar to lymphocyteactivation-associated protein [Homosapiens] [H. sapiens], ESTs, Weaklysimilar to KEAP_RAT Kelch-like ECH-associated protein 1 (Cytosolic inhibitorof Nrf2) (INrf2) [R. norvegicus], Kelch-likeECH-associated protein 1, Musmusculus, Similar to KIAA0952 protein,clone MGC: 25591 IMAGE: 4011475,mRNA, complete cds, RIKEN cDNA2700038B03 gene, kelch-like ECH-associated protein 1240221170NM_053585s, tESTs, Highly similar to MAP-kinaseactivating death domain; Rab3GDP/GTP exchange protein [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to MAP-kinase activatingdeath domain; Rab3 GDP/GTPexchange protein [Rattus norvegicus][R. norvegicus], MAP-kinase activatingdeath domain, Mus musculus, Similar toMAP-kinase activating death domain,clone MGC: 7838 IMAGE: 3500720,mRNA, complete cds, RIKEN cDNA2010004M01 gene, suppression oftumorigenicity 5240811794NM_053606iiESTs, Highly similar to Matrixmetalloproteinase 23 [Rattus norvegicus][R. norvegicus], matrix metalloproteinase23, matrix metalloproteinase 23A, matrixmetalloproteinase 23B22111991NM_030995h, lESTs, Highly similar to microtubule-associated protein 1a [Rattusnorvegicus] [R. norvegicus], ESTs,Moderately similar to microtubule-associated protein 1a [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to microtubule-associated protein 1a [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to MAPA_MOUSEMicrotubule-associated protein 1A (MAP1A) [M. musculus], chromatin assemblyfactor 1, subunit A (p150), expressedsequence AI853608, microtubule-associated protein 1A115814434AI112291llESTs, Highly similar to multiple PDZdomain protein [Mus musculus][M. musculus], Homo sapiens cDNAFLJ25282 fis, clone STM06685, highlysimilar to Rattus norvegicus mRNA formulti PDZ domain protein, ligand ofnumb-protein × 1, multiple PDZ domainprotein23281169NM_031789dESTs, Highly similar to NF-E2-relatedfactor 2 [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar toNF-E2-related factor 2 [Rattusnorvegicus] [R. norvegicus], nuclearfactor (erythroid-derived 2)-like 2,nuclear factor, erythroid derived 2, like 3,nuclear, factor, erythroid derived 2, like 223281170NM_031789d, l, m, jj,ESTs, Highly similar to NF-E2-relatedkkfactor 2 [Rattus norvegicus][R. norvegicus], ESTs, Weakly similar toNF-E2-related factor 2 [Rattusnorvegicus] [R. norvegicus], nuclearfactor (erythroid-derived 2)-like 2,nuclear factor, erythroid derived 2, like 3,nuclear, factor, erythroid derived 2, like 229016215AA874999h, l, n, oESTs, Highly similar to proteintranslocation complex beta; proteintransport protein SEC61 beta subunit[Homo sapiens] [H. sapiens], proteintranslocation complex beta11624969AI113008l, k, n, oESTs, Highly similar to proteoglycan 3(megakaryocyte stimulating factor,articular superficial zone protein) [Musmusculus] [M. musculus], proteoglycan 4(megakaryocyte stimulating factor,articular superficial zone protein),proteoglycan 4, (megakaryocytestimulating factor, articular superficialzone protein, camptodactyly,arthropathy, coxa vara, pericarditissyndrome), vitronectin224022205NM_031105bESTs, Highly similar to ribosomalprotein L36a; 60S ribosomal protein L44;L44-like ribosomal protein; ribosomalprotein L44; ribosomal protein L36ahomologue; 60S ribosomal protein L36a[Homo sapiens] [H. sapiens], ESTs,Moderately similar to ribosomal proteinL36a; 60S ribosomal protein L44; L44-like ribosomal protein; ribosomal proteinL44; ribosomal protein L36a homologue;60S ribosomal protein L36a [Homosapiens] [H. sapiens], RIKEN cDNA2410038A03 gene, ribosomal proteinL36a-like, ribosomal protein L44239317298NM_053553cc, ddESTs, Highly similar to synaptogyrin 2[Rattus norvegicus] [R. norvegicus], Musmusculus 18 days embryo whole bodycDNA, RIKEN full-length enriched library,clone: 1110032G03: synaptogyrin 2, fullinsert sequence, synaptogyrin 2247923307NM_057119eESTs, Highly similar to TLS-associatedserine-arginine protein 1, isoform 1; TLS-associated serine-arginine protein 1;TLS-associated protein TASR [Homosapiens] [H. sapiens], ESTs, Weaklysimilar to splicing factor, arginine/serine-rich (transformer 2 Drosophila homolog)10 [Rattus norvegicus] [R. norvegicus],Mus musculus hexaribonucleotidebinding protein 3 (Hrnbp3) mRNA, partialcds, RIKEN cDNA 1500010G04 gene,neural-salient serine/arginine-rich, silica-induced gene 41, splicing factor,arginine/serine-rich 10 (transformer 2homolog, Drosophila)247923310NM_057119e, s, tESTs, Highly similar to TLS-associatedserine-arginine protein 1, isoform 1; TLS-associated serine-arginine protein 1;TLS-associated protein TASR [Homosapiens] [H. sapiens], ESTs, Weaklysimilar to splicing factor, arginine/serine-rich (transformer 2 Drosophila homolog)10 [Rattus norvegicus] [R. norvegicus],Mus musculus hexaribonucleotidebinding protein 3 (Hrnbp3) mRNA, partialcds, RIKEN cDNA 1500010G04 gene,neural-salient serine/arginine-rich, silica-induced gene 41, splicing factor,arginine/serine-rich 10 (transformer 2homolog, Drosophila)164120082AI639488dESTs, Highly similar to 1814460A p53-associated protein [H. sapiens], Mdm2,transformed 3T3 cell double minute 2,p53 binding protein (mouse),transformed mouse 3T3 cell doubleminute 237717350AA892240l, m, iiESTs, Highly similar to 2008109A setgene [Rattus norvegicus] [R. norvegicus],ESTs, Highly similar to SET_HUMANSET PROTEIN [H. sapiens], SETtranslocation, SET translocation (myeloidleukemia-associated)152923296AI233316hhESTs, Highly similar to 40SRIBOSOMAL PROTEIN S23 [H. sapiens],Mus musculus, Similar to mitochondrialribosomal protein S12, cloneMGC: 13892 IMAGE: 4209358, mRNA,complete cds, mitochondrial ribosomalprotein S12, ribosomal protein S23200620848NM_017343bb, hh, jj,ESTs, Highly similar to A37100 myosinkkregulatory light chain A, smooth muscle -rat [R. norvegicus], RIKEN cDNA2900073G15 gene, myosin light chain,phosphorylatable, cardiac ventricles,myosin regulatory light chain, myosin,light polypeptide, regulatory, non-sarcomeric (20 kD)200620849NM_017343ggESTs, Highly similar to A37100 myosinregulatory light chain A, smooth muscle -rat [R. norvegicus], RIKEN cDNA2900073G15 gene, myosin light chain,phosphorylatable, cardiac ventricles,myosin regulatory light chain, myosin,light polypeptide, regulatory, non-sarcomeric (20 kD)17516971AA819691n, oESTs, Highly similar to A38351phosphoprotein phosphatase 2-alpharegulatory chain [H. sapiens], RIKENcDNA 2410004D02 gene, proteinphosphatase 2 (formerly 2A), regulatorysubunit B (PR 52), alpha isoform246616962NM_053999u, vESTs, Highly similar to A38351phosphoprotein phosphatase 2-alpharegulatory chain [H. sapiens], RIKENcDNA 2410004D02 gene, proteinphosphatase 2 (formerly 2A), regulatorysubunit B (PR 52), alpha isoform247417709NM_057101u, vESTs, Highly similar to A45445 janusinprecursor, long form - rat [R. norvegicus],ESTs, Weakly similar to JQ1322tenascin precursor - mouse[M. musculus], Tenascin-R (Restrictin,janusin, J1-160/180), tenascin R(restrictin, janusin), tenascin XB26715884AA866276d, f, g, rESTs, Highly similar to A54602microtubule-associated serine/threonineprotein kinase MAST205 - mouse[M. musculus], ESTs, Moderately similarto A54602 microtubule-associatedserine/threonine protein kinaseMAST205 - mouse [M. musculus], Homosapiens cDNA: FLJ21699 fis, cloneCOL09829, KIAA0303 protein,KIAA0561 protein, KIAA0807 protein,Mus musculus adult male cecum cDNA,RIKEN full-length enriched library,clone: 9130026D18: syntrophinassociated serine/threonine kinase, fullinsert sequence, microtubule associatedtestis specific serine/threonine proteinkinase, syntrophin associatedserine/threonine kinase25251791NM_133541llESTs, Highly similar to A56011transcription factor IIIC alpha chain - rat[R. norvegicus], ESTs, Moderately similarto A56011 transcription factor IIIC alphachain - rat [R. norvegicus], ESTs, Weaklysimilar to A56011 transcription factor IIICalpha chain - rat [R. norvegicus], generaltranscription factor IIIC 1, generaltranscription factor IIIC, polypeptide 1(alpha subunit, 220 kD)25421530NM_134397a, e, jj,ESTs, Highly similar to A59252 myosinkkheavy chain, nonmuscle, form IIB[H. sapiens], ESTs, Weakly similar toneuronal thread protein [Homo sapiens][H. sapiens], ESTs, Weakly similar toLORICRIN [M. musculus], Homo sapiensmRNA; cDNA DKFZp434G227 (fromclone DKFZp434G227), Homo sapiens,clone IMAGE: 4111094, mRNA, partialcds, KIAA0638 protein, Mus musculus,Similar to hypothetical protein MGC2705,clone MGC: 36471 IMAGE: 5359433,mRNA, complete cds, Mus musculus,clone MGC: 32394 IMAGE: 5037534,mRNA, complete cds, expressedsequence AI036317, expressedsequence AV253284, expressedsequence C77080, loricrin243111606NM_053795ggESTs, Highly similar to ANK1 MOUSEANKYRIN 1 [M. musculus], ESTs,Weakly similar to ANK1 MOUSEANKYRIN 1 [M. musculus], GASZ, Gasz,Homo sapiens cDNA FLJ25053 fis, cloneCBL04266, Mus musculus ankyrinrepeat domain-containing SOCS boxprotein Asb-16 mRNA, complete cds,Mus musculus, Similar to hypotheticalprotein DKFZp564O043, cloneMGC: 36949 IMAGE: 4946879, mRNA,complete cds, RIKEN cDNA1110058D09 gene, RIKEN cDNA4933400N19 gene, hypothetical proteinsimilar to ankyrin repeat-containingpriotein AKR1, likely homolog of ratkinase D-interacting substance of 220 kDa,regulatory factor X-associatedankyrin-containing protein205717507NM_019299f, gESTs, Highly similar to B Chain B,Peptide-ln-Groove Interactions LinkTarget Proteins To The B-Propeller OfClathrin [R. norvegicus], RIKEN cDNA1700034F02 gene, clathrin, heavypolypeptide (Hc), clathrin, heavypolypeptide-like 1, expressed sequenceR7473283113787AI011462cc, ddESTs, Highly similar to C259_HUMANPROTEIN C21ORF59 [H. sapiens],chromosome 21 open reading frame 59262720386U68562cc, ddESTs, Highly similar to CH60_HUMAN60 KDA HEAT SHOCK PROTEIN,MITOCHONDRIAL PRECURSOR[H. sapiens], ESTs, Moderately similar toCH60 MOUSE 60 KDA HEAT SHOCKPROTEIN, MITOCHONDRIALPRECURSOR [M. musculus], ESTs,Weakly similar to CH60_HUMAN 60 KDAHEAT SHOCK PROTEIN,MITOCHONDRIAL PRECURSOR[H. sapiens], heat shock 60 kD protein 1(chaperonin), heat shock protein, 60 kDa64412426AA955760u, vESTs, Highly similar to CIA1_HUMANWD40-REPEAT CONTAININGPROTEIN CIAO 1 [H. sapiens], ESTs,Weakly similar to LIS1_MOUSE Platelet-activating factor acetylhydrolase IB alphasubunit (PAF acetylhydrolase 45 kDasubunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)(Lissencephaly-1 protein) (LIS-1)[R. norvegicus], F-box and WD-40domain protein 7 (archipelago homolog,Drosophila), Homo sapiens cDNAFLJ31861 fis, clone NT2RP7001319,Homo sapiens, clone MGC: 4710IMAGE: 3534806, mRNA, complete cds,Mus musculus F-box-WD40 repeatprotein 6 (Fbxw6) mRNA, complete cds,Mus musculus, Similar to RIKEN cDNA1500041N16 gene, clone MGC: 12066IMAGE: 3708188, mRNA, complete cds,nuclear receptor co-repressor/HDAC3complex subunit, platelet-activatingfactor acetylhydrolase beta subunit (PAF-AH beta), platelet-activating factoracetylhydrolase, isoform 1b, beta1subunit, platelet-activating factoracetylhydrolase, isoform lb, alphasubunit (45 kD), transducin (beta)-like 1135917570AI177683n, o, hhESTs, Highly similar to DDRT helix-destabilizing protein - rat [R. norvegicus],ESTs, Highly similar to ROA3_HUMANHETEROGENEOUS NUCLEARRIBONUCLEOPROTEIN A3 [H. sapiens],ESTs, Highly similar to S12520 coreprotein A1 [H. sapiens], ESTs, Highlysimilar to heterogeneous ribonuclearparticle protein A1 [H. sapiens], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], ESTs, Weakly similar toROA2 MOUSE HETEROGENEOUSNUCLEAR RIBONUCLEOPROTEINSA2/B1 [M. musculus], Mus musculus,similar to heterogeneous nuclearribonucleoprotein A3 (H. sapiens), cloneMGC: 37309 IMAGE: 4975085, mRNA,complete cds, RIKEN cDNA2610510D13 gene, RIKEN cDNA3010025E17 gene, heterogeneousnuclear ribonucleoprotein A1,heterogeneous nuclear ribonucleoproteinA2/B1, heterogeneous nuclearribonucleoprotein A3, hypotheticalprotein 238513717612AA799511llESTs, Highly similar to DDRT helix-destabilizing protein - rat [R. norvegicus],ESTs, Highly similar to S12520 coreprotein A1 [H. sapiens], ESTs, Highlysimilar to heterogeneous ribonuclearparticle protein A1 [H. sapiens], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], ESTs, Weakly similar toROA2 MOUSE HETEROGENEOUSNUCLEAR RIBONUCLEOPROTEINSA2/B1 [M. musculus], Mus musculus,similar to heterogeneous nuclearribonucleoprotein A3 (H. sapiens), cloneMGC: 37309 IMAGE: 4975085, mRNA,complete cds, RIKEN cDNA2610510D13 gene, RIKEN cDNA3010025E17 gene, heterogeneousnuclear ribonucleoprotein A1,heterogeneous nuclear ribonucleoproteinA2/B118117614AA848306bESTs, Highly similar to DDRT helix-destabilizing protein - rat [R. norvegicus],ESTs, Highly similar to S12520 coreprotein A1 [H. sapiens], ESTs, Highlysimilar to heterogeneous ribonuclearparticle protein A1 [H. sapiens], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], ESTs, Weakly similar toROA2 MOUSE HETEROGENEOUSNUCLEAR RIBONUCLEOPROTEINSA2/B1 [M. musculus], Mus musculus,similar to heterogeneous nuclearribonucleoprotein A3 (H. sapiens), cloneMGC: 37309 IMAGE: 4975085, mRNA,complete cds, RIKEN cDNA2610510D13 gene, RIKEN cDNA3010025E17 gene, heterogeneousnuclear ribonucleoprotein A1,heterogeneous nuclear ribonucleoproteinA2/B11922075AA849394u, vESTs, Highly similar to DDRT helix-destabilizing protein - rat [R. norvegicus],ESTs, Highly similar to S12520 coreprotein A1 [H. sapiens], ESTs, Highlysimilar to heterogeneous ribonuclearparticle protein A1 [H. sapiens], ESTs,Moderately similar to S38384 SEB4protein - mouse [M. musculus], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], ESTs, Weakly similar toS38384 SEB4 protein - mouse[M. musculus], heterogeneous nuclearribonucleoprotein A1, seb4-like(Xenopus laevis)10625740AI072092l, mESTs, Highly similar to DYNC_HUMANDYNACTIN, 50 KD ISOFORM[H. sapiens], dynactin 2 (p50)42116482AA892940ggESTs, Highly similar to EF2_RATElongation factor 2 (EF-2)[R. norvegicus], ESTs, Weakly similar toEF2_MOUSE Elongation factor 2 (EF-2)[M. musculus], U5 small nuclearribonucleoprotein 116 kDa, eukaryotictranslation elongation factor 2266581AA799412eESTs, Highly similar to ERR3_HUMANESTROGEN-RELATED RECEPTORGAMMA [H. sapiens], estrogen relatedreceptor, alpha, estrogen-relatedreceptor alpha, estrogen-related receptorgamma80915644AI010256kkESTs, Highly similar to H33_HUMANHISTONE H3.3 [H. sapiens], H3 histone,family 3A, H3 histone, family 3B, H3histone, family 3B (H3.3B), RIKEN cDNA1810027O10 gene116724212AI36747cc, ddESTs, Highly similar to H33_HUMANHISTONE H3.3 [H. sapiens], H3 histone,family 3A, H3 histone, family 3B, H3histone, family 3B (H3.3B), RIKEN cDNA1810027O10 gene246215642NM_053985dESTs, Highly similar to H33_HUMANHISTONE H3.3 [H. sapiens], H3 histone,family 3A, H3 histone, family 3B, H3histone, family 3B (H3.3B), RIKEN cDNA1810027O10 gene246215645NM_053985dESTs, Highly similar to H33_HUMANHISTONE H3.3 [H. sapiens], H3 histone,family 3A, H3 histone, family 3B, H3histone, family 3B (H3.3B), RIKEN cDNA1810027O10 gene201024428NM_017356llESTs, Highly similar to HIPP_HUMANNeuron specific calcium-binding proteinhippocalcin (P23K) (Calcium-bindingprotein BDR-2) [R. norvegicus], ESTs,Moderately similar to VIS3 MOUSEVISININ-LIKE PROTEIN 3 [M. musculus],Mus musculus, clone MGC: 21424IMAGE: 4500919, mRNA, complete cds,expressed sequence AI848120,guanylate cyclase activator 1A (retina),guanylate cyclase activator 1B (retina),guanylate cyclase activator 1C,guanylate cyclase activator 1a (retina),hippocalcin-like 1, hypothetical proteinFLJ11767, neurocalcin delta58420795AA944397e, eeESTs, Highly similar to HS9B_RAT Heatshock protein HSP 90-beta (HSP 84)[R. norvegicus], ESTs, Highly similar toT46243 hypothetical proteinDKFZp761K0511.1 [H. sapiens], Musmusculus, clone IMAGE: 3584589,mRNA, partial cds, expressed sequenceC81438, heat shock 90 kD protein 1,beta, heat shock protein, 84 kDa 1, heatshock protein, 86 kDa 1133516518AI176546d, ee, ff,ESTs, Highly similar to HS9B_RAT Heatjj, kkshock protein HSP 90-beta (HSP 84)[R. norvegicus], ESTs, Highly similar toT46243 hypothetical proteinDKFZp761K0511.1 [H. sapiens], Musmusculus, clone IMAGE: 3584589,mRNA, partial cds, expressed sequenceC81438, heat shock 90 kD protein 1,beta, heat shock protein, 84 kDa 1, heatshock protein, 86 kDa 11725104AA685903d, e, rESTs, Highly similar to HS9B_RAT Heatshock protein HSP 90-beta (HSP 84)[R. norvegicus], ESTs, Highly similar toT46243 hypothetical proteinDKFZp761K0511.1 [H. sapiens], RIKENcDNA 1810014B01 gene, expressedsequence C81438, heat shock 90 kDprotein 1, beta, heat shock protein, 84 kDa1, tumor rejection antigen (gp96) 1,tumor rejection antigen gp96260318647S69316d, eESTs, Highly similar to HS9B_RAT Heatshock protein HSP 90-beta (HSP 84)[R. norvegicus], ESTs, Highly similar toT46243 hypothetical proteinDKFZp761K0511.1 [H. sapiens], RIKENcDNA 1810014B01 gene, expressedsequence C81438, heat shock 90 kDprotein 1, beta, heat shock protein, 84 kDa1, tumor rejection antigen (gp96) 1,tumor rejection antigen gp96100319093AI058869l, mESTs, Highly similar to HumanTranslation Initiation Factor Eif1, Nmr, 29Structures [H. sapiens], putativetranslation initiation factor, suppressor ofinitiator codon mutations, relatedsequence 1 (S. cerevisiae)150419094AI232021gESTs, Highly similar to HumanTranslation Initiation Factor Eif1, Nmr, 29Structures [H. sapiens], putativetranslation initiation factor, suppressor ofinitiator codon mutations, relatedsequence 1 (S. cerevisiae)38722868AA892391ee, ffESTs, Highly similar to I48722 zincfinger protein - mouse [M. musculus],ESTs, Moderately similar to S47073finger protein HZF2, Krueppel-related[H. sapiens], Homo sapiens cDNAFLJ31843 fis, clone NT2RP7000271,moderately similar to Mus musculus zincfinger protein 276 C2H2 type (Zfp276)mRNA, Homo sapiens cDNA: FLJ22829fis, clone KAIA4075, highly similar toHSCH16FAA Homo sapiens mRNA forFAA protein, ciliary neurotropic factor,hypothetical protein BC016816,hypothetical protein FLJ20531, zincfinger protein 354A, zinc finger protein354B110522487AI102578eESTs, Highly similar to I49523 Mouseprimary response gene B94 mRNA,3′end - mouse [M. musculus], RIKENcDNA 1600013K19 gene, hypotheticalprotein MGC16332, tumor necrosisfactor, alpha-induced protein 2141019828AI180087dESTs, Highly similar to I49636 DNA-binding protein - mouse [M. musculus],ESTs, Highly similar to OZF_HUMANZINC FINGER PROTEIN OZF[H. sapiens], ESTs, Moderately similar toI49636 DNA-binding protein - mouse[M. musculus], ESTs, Weakly similar toOZF_HUMAN ZINC FINGER PROTEINOZF [H. sapiens], ESTs, Weakly similarto Z177_HUMAN ZINC FINGERPROTEIN 177 [H. sapiens], Homosapiens mRNA; cDNA DKFZp547C146(from clone DKFZp547C146), Musmusculus, Similar to zinc finger protein97, clone MGC: 6111 IMAGE: 3494875,mRNA, complete cds, Pancreas zincfinger protein, see also D1Bda10\2, zincfinger protein 177, zinc finger protein260, zinc finger protein 63, zinc fingerprotein 977078786AA996993dESTs, Highly similar to I58408 IK factor[H. sapiens], IK cytokine87016686AI013160u, vESTs, Highly similar to I63168 geneUbe1x protein - rat (fragment)[R. norvegicus], ubiquitin-activatingenzyme E1 (A1S9T and BN75temperature sensitivity complementing),ubiquitin-activating enzyme E1, Chr X,ubiquitin-activating enzyme E1, Chr Y 1,ubiquitin-activating enzyme E1-like74819649AF016387jj, kkESTs, Highly similar to I67428 retinoicacid receptor homolog - rat (fragment)[R. norvegicus], retinoid X receptorgamma, retinoid X receptor, gamma74819650AF016387jj, kkESTs, Highly similar to I67428 retinoicacid receptor homolog - rat (fragment)[R. norvegicus], retinoid X receptorgamma, retinoid X receptor, gamma256311840NM_138911eESTs, Highly similar to lEFS_HUMANTRANSFORMATION-SENSITIVEPROTEIN IEF SSP 3521 [H. sapiens],ESTs, Weakly similar to small glutamine-rich tetratricopeptide repeat (TPR)containing protein (SGT) [Rattusnorvegicus] [R. norvegicus], Musmusculus, clone MGC: 27660IMAGE: 4527683, mRNA, complete cds,RIKEN cDNA 5330427H01 gene,hypothetical protein FLJ12788, smallglutamine-rich tetratricopeptide repeat(TPR) containing protein (SGT), smallglutamine-rich tetratricopeptide repeat(TPR)-containing, stress-inducedphosphoprotein 1, stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)138618848AI178816n, oESTs, Highly similar to IF4E_HUMANEUKARYOTIC TRANSLATIONINITIATION FACTOR 4E [H. sapiens],RIKEN cDNA 1300018P11 gene, RIKENcDNA 2700069E09 gene, eukaryotictranslation initiation factor 4E, eukaryotictranslation initiation factor 4E-like 3121821660AI169751a, kkESTs, Highly similar to IFM3_HUMANINTERFERON-INDUCEDTRANSMEMBRANE PROTEIN 3[H. sapiens], ESTs, Highly similar toS17182 interferon-induced protein 1-8U[H. sapiens], RIKEN cDNA 1110004C05gene, interferon induced transmembraneprotein 1 (9-27), interferon inducedtransmembrane protein 3 (1-8U)266521657X61381d, j, k, m,ESTs, Highly similar to IFM3_HUMANy, z, kkINTERFERON-INDUCEDTRANSMEMBRANE PROTEIN 3[H. sapiens], ESTs, Highly similar toS17182 interferon-induced protein 1-8U[H. sapiens], RIKEN cDNA 1110004C05gene, interferon induced transmembraneprotein 1 (9-27), interferon inducedtransmembrane protein 3 (1-8U)12762140AI172272hhESTs, Highly similar to JC4577transcription elongation factor T1[H. sapiens], ESTs, Highly similar toTranscriptional Elongation Factor Sii[H. sapiens], ESTs, Weakly similar toJC5430 transcription elongation factor S-II-T1, testis-specific - mouse[M. musculus], Homo sapiens cDNA:FLJ23371 fis, clone HEP16068, highlysimilar to HSTFIISH Homo sapiensmRNA for transcription elongation factorTFIIS, PHD finger protein 3, transcriptionelongation factor A (SII), 325603015NM_138895aa, bbESTs, Highly similar to JE0190polyubiquitin unit [H. sapiens], ESTs,Highly similar to UQHUC polyubiquitin 9[H. sapiens], Homo sapiens, Similar toorosomucoid 1, clone MGC: 24263IMAGE: 3934516, mRNA, complete cds,expressed sequence AL033289,ubiquitin B, ubiquitin C3222846AA875639aESTs, Highly similar to LB4D_HUMANNADP-DEPENDENT LEUKOTRIENE B412-HYDROXYDEHYDROGENASE[H. sapiens], ESTs, Weakly similar toLB4D_HUMAN NADP-DEPENDENTLEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE[H. sapiens], Homo sapiens, cloneIMAGE: 4793702, mRNA, Mus musculus,clone MGC: 32469 IMAGE: 5050433,mRNA, complete cds, crystallin, zeta,fatty acid synthase, quinoneoxidoreductase homolog18901258NM_013185hhESTs, Highly similar to LCK MOUSEPROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK [M. musculus],RIKEN cDNA 8430404F20 gene,hemopoietic cell kinase, lymphocyteprotein tyrosine kinase, lymphocyte-specific protein tyrosine kinase, src-related kinase lacking C-terminalregulatory tyrosine and N-terminalmyristylation sites10148729AI059485w, xESTs, Highly similar to MEM2 RATMEMBRANE-ASSOCIATED PROTEINHEM-2 [R. norvegicus], ESTs, Highlysimilar to NCP1_RAT Nck-associatedprotein 1 (NAP 1) (p125Nap1)(Membrane-associated protein HEM-2)[R. norvegicus], NCK-associated protein 12583305NM_145773u, vESTs, Highly similar to MXI1_RAT MAXinteracting protein 1 (MXI1 protein)[R. norvegicus], ESTs, Moderately similarto MXI1_RAT MAX interacting protein 1(MXI1 protein) [R. norvegicus], Homosapiens cDNA FLJ32472 fis, cloneSKNMC2000356, highly similar to Musmusculus Max-interacting transcriptionalrepressor (Mad3) mRNA, MAXinteracting protein 1, Max interactingprotein 1, likely ortholog of mouse Maxdimerization protein 318843465NM_013160h, IESTs, Highly similar to MXI1_RAT MAXinteracting protein 1 (MXI1 protein)[R. norvegicus], ESTs, Weakly similar toMXI1_RAT MAX interacting protein 1(MXI1 protein) [R. norvegicus], MAXdimerization protein, MAX interactingprotein 1, Max interacting protein 118921970NM_013194ggESTs, Highly similar to MYH9_RATMyosin heavy chain, nonmuscle type A(Cellular myosin heavy chain, type A)(Nonmuscle myosin heavy chain-A)(NMMHC-A) [R. norvegicus], ESTs,Highly similar to MYHA_MOUSE Myosinheavy chain, nonmuscle type B (Cellularmyosin heavy chain, type B) (Nonmusclemyosin heavy chain-B) (NMMHC-B)[M. musculus], ESTs, Weakly similar toMYH9_RAT Myosin heavy chain,nonmuscle type A (Cellular myosinheavy chain, type A) (Nonmuscle myosinheavy chain-A) (NMMHC-A)[R. norvegicus], ESTs, Weakly similar toMYHA_MOUSE Myosin heavy chain,nonmuscle type B (Cellular myosinheavy chain, type B) (Nonmuscle myosinheavy chain-B) (NMMHC-B)[M. musculus], RIKEN cDNA2400004E04 gene, RIKEN cDNA5730504C04 gene, TGFB1-induced anti-apoptotic factor 1, myosin heavy chainIX, myosin, heavy polypeptide 9, non-muscle, protein tyrosine phosphatase,receptor-type, F interacting protein,binding protein 222813802AA858853b, l, mESTs, Highly similar to NTC1_RATNeurogenic locus notch homolog protein1 precursor (Notch 1) [R. norvegicus],Homo sapiens cDNA FLJ25053 fis, cloneCBL04266, Notch gene homolog 1,(Drosophila), Notch homolog 1,translocation-associated (Drosophila),hypothetical protein similar to ankyrinrepeat-containing priotein AKR1, likelyhomolog of rat kinase D-interactingsubstance of 220 kDa235525529NM_033096n, oESTs, Highly similar to P2CB_HUMANPROTEIN PHOSPHATASE 2C BETAISOFORM [H. sapiens], ESTs, Weaklysimilar to P2CB_HUMAN PROTEINPHOSPHATASE 2C BETA ISOFORM[H. sapiens], Homo sapiens cDNAFLJ30553 fis, clone BRAWH2003689,highly similar to Mus musculus clonemouse1-9 putative protein phosphatasetype 2C mRNA, protein phosphatase 1B(formerly 2C), magnesium-dependent,beta isoform, protein phosphatase 1B,magnesium dependent, beta isoform235525569NM_033096rESTs, Highly similar to P2CB_HUMANPROTEIN PHOSPHATASE 2C BETAISOFORM [H. sapiens], ESTs, Weaklysimilar to P2CB_HUMAN PROTEINPHOSPHATASE 2C BETA ISOFORM[H. sapiens], Homo sapiens cDNAFLJ30553 fis, clone BRAWH2003689,highly similar to Mus musculus clonemouse1-9 putative protein phosphatasetype 2C mRNA, protein phosphatase 1B(formerly 2C), magnesium-dependent,beta isoform, protein phosphatase 1B,magnesium dependent, beta isoform235519148NM_033096h, lESTs, Highly similar to P2CB_HUMANPROTEIN PHOSPHATASE 2C BETAISOFORM [H. sapiens], ESTs, Weaklysimilar to P2CB_HUMAN PROTEINPHOSPHATASE 2C BETA ISOFORM[H. sapiens], Homo sapiens cDNAFLJ30553 fis, clone BRAWH2003689,highly similar to Mus musculus clonemouse1-9 putative protein phosphatasetype 2C mRNA, protein phosphatase 1B(formerly 2C), magnesium-dependent,beta isoform, protein phosphatase 1B,magnesium dependent, beta isoform254019840NM_134353llESTs, Highly similar to PAB1_HUMANPOLYADENYLATE-BINDING PROTEIN1 [H. sapiens], ESTs, Moderately similarto NUCLEOLIN [M. musculus], ESTs,Moderately similar to PAB1 MOUSEPOLYADENYLATE-BINDING PROTEIN1 [M. musculus], ESTs, Weakly similar toNUCL_HUMAN NUCLEOLIN[H. sapiens], ESTs, Weakly similar toPAB1 MOUSE POLYADENYLATE-BINDING PROTEIN 1 [M. musculus],Nucleolin, RIKEN cDNA 4932702K14gene, nucleolin, pigpen, poly A bindingprotein, cytoplasmic 1, poly(A) bindingprotein, cytoplasmic 3, poly(A) bindingprotein, cytoplasmic, pseudogene 2246418025NM_053989w, xESTs, Highly similar to PAB1_HUMANPOLYADENYLATE-BINDING PROTEIN1 [H. sapiens], RIKEN cDNA2810411E22 gene, RIKEN cDNA4432411E13 gene, RIKEN cDNA4930431E10 gene223512638NM_031099eESTs, Highly similar to PC4210ribosomal protein L5 [H. sapiens],ribosomal protein L5223512639NM_031099gESTs, Highly similar to PC4210ribosomal protein L5 [H. sapiens]ribosomal protein L58967212AI014065ggESTs, Highly similar to PMX1_MOUSEPaired mesoderm homeobox protein 1(PRX-1) (Paired related homeoboxprotein 1) (Homeobox protein MhoX)(Homeobox protein K-2) (Rhox)[R. norvegicus], ESTs, Weakly similar toPMX1_MOUSE Paired mesodermhomeobox protein 1 (PRX-1) (Pairedrelated homeobox protein 1) (Homeoboxprotein MhoX) (Homeobox protein K-2)(Rhox) [R. norvegicus], paired mesodermhomeo box 1, paired related homeobox1, paired related homeobox protein13004445AI175466rESTs, Highly similar to RASH_RATTRANSFORMING PROTEIN P21/H-RAS1 (C-H-RAS) [R. norvegicus], Harvey ratsarcoma oncogene, subgroup R, Harveyrat sarcoma virus oncogene, Musmusculus, Similar to v-Ha-ras Harvey ratsarcoma viral oncogene homolog, cloneMGC: 19390 IMAGE: 3152667, mRNA,complete cds, related RAS viral (r-ras)oncogene homolog, v-Ha-ras Harvey ratsarcoma viral oncogene homolog43818542AA893493gESTs, Highly similar to RL26_HUMAN60S RIBOSOMAL PROTEIN L26[H. sapiens], ESTs, Highly similar toS33713 ribosomal protein L26, cytosolic[H. sapiens], ESTs, Moderately similar toRL26_HUMAN 60S RIBOSOMALPROTEIN L26 [H. sapiens], ribosomalprotein L26, ribosomal protein L26-like 1264618541X14671gESTs, Highly similar to RL26_HUMAN60S RIBOSOMAL PROTEIN L26[H. sapiens], ESTs, Highly similar toS33713 ribosomal protein L26, cytosolic[H. sapiens], ESTs, Moderately similar toRL26_HUMAN 60S RIBOSOMALPROTEIN L26 [H. sapiens], ribosomalprotein L26, ribosomal protein L26-like 11903815NM_013224g, h, l, w, xESTs, Highly similar to RS26_HUMAN40S RIBOSOMAL PROTEIN S26[H. sapiens], Homo sapiens, cloneIMAGE: 4100953, mRNA, polymerase(RNA) II (DNA directed) polypeptide D,ribosomal protein S268115011AA799893hhESTs, Highly similar to S12520 coreprotein A1 [H. sapiens], ESTs, Highlysimilar to heterogeneous ribonuclearparticle protein A1 [H. sapiens], ESTs,Moderately similar to heterogeneousribonuclear particle protein A1[H. sapiens], Mus musculus, Similar toTAR DNA binding protein, cloneMGC: 19284 IMAGE: 4016437, mRNA,complete cds, RIKEN cDNA2610510D13 gene, RIKEN cDNA4930547K05 gene, heterogeneousnuclear ribonucleoprotein A1,heterogeneous nuclear ribonucleoproteinA324576357NM_053969dESTs, Highly similar to S57449 fuscaprotein homolog - rat [R. norvegicus],ESTs, Weakly similar to S57449 fuscaprotein homolog - rat [R. norvegicus], Gprotein pathway suppressor 1, Musmusculus, Similar to G protein pathwaysuppressor 1, clone MGC: 7191IMAGE: 3481979, mRNA, complete cds,RIKEN cDNA 2400006A19 gene81718691AI010605bESTs, Highly similar to S63665 titinprotein [H. sapiens], ESTs, Weaklysimilar to S63665 titin protein[H. sapiens], Homo sapiens cDNAFLJ31994 fis, clone NT2RP7009215,Homo sapiens, Similar to RIKEN cDNA1810054O13 gene, cloneIMAGE: 3845933, mRNA, partial cds259210544NM_152935s, t, u, vESTs, Highly similar to S68215 Mas 20protein [H. sapiens], Homo sapiens cDNAFLJ30361 fis, clone BRACE2007764,RIKEN cDNA 1810060K07 gene, RIKENcDNA 4930553D19 gene, translocase ofouter mitochondrial membrane 20(yeast) homolog6020982AA799657d, e, iiESTs, Highly similar to S68418 proteinphosphatase 1M chain M110 isoform -rat [R. norvegicus], ESTs, Weakly similarto S68418 protein phosphatase 1Mchain M110 isoform - rat (fragment)[R. norvegicus], expressed sequenceAI449786, expressed sequenceAI746547, leukocyte receptor cluster(LRC) member 3, myosin phosphatase,target subunit 1, protein phosphatase 1,regulatory (inhibitor) subunit 12A138823043AI178968bESTs, Highly similar to S70642 ubiquitinligase Nedd4 - rat (fragment)[R. norvegicus], ESTs, Moderately similarto S70642 ubiquitin ligase Nedd4 - rat(fragment) [R. norvegicus], Musmusculus, clone MGC: 12070IMAGE: 3708271, mRNA, complete cds,RIKEN cDNA 1700056O17 gene, RIKENcDNA 5830462N02 gene, expressedsequence AW212605, neural precursorcell expressed, developmentally down-regulated 4, neural precursor cellexpressed, developmentally down-regulated gene 4a, thyroid hormonereceptor interactor 12, ubiquitin proteinligase E3A25081502NM_130746aaESTs, Highly similar to SL56_RATSODIUM-DEPENDENT MULTIVITAMINTRANSPORTER (NA(+)-DEPENDENTMULTIVITAMIN TRANSPORTER)[R. norvegicus], ESTs, Highly similar toSL56_RAT Sodium-dependentmultivitamin transporter (Na(+)-dependent multivitamin transporter)[R. norvegicus], Homo sapiens cDNAFLJ14949 fis, clone PLACE2000341,highly similar to Homo sapiens sodium-dependent multivitamin transporter(SMVT) mRNA, Homo sapiens mRNA; cDNA DKFZp434F152 (from cloneDKFZp434F152), solute carrier family 5(sodium iodide symporter), member 5,solute carrier family 5 (sodium-dependent vitamin transporter), member 625081503NM_130746dESTs, Highly similar to SL56_RATSODIUM-DEPENDENT MULTIVITAMINTRANSPORTER (NA(+)-DEPENDENTMULTIVITAMIN TRANSPORTER)[R. norvegicus], ESTs, Highly similar toSL56_RAT Sodium-dependentmultivitamin transporter (Na(+)-dependent multivitamin transporter)[R. norvegicus], Homo sapiens cDNAFLJ14949 fis, clone PLACE2000341,highly similar to Homo sapiens sodium-dependent multivitamin transporter(SMVT) mRNA, Homo sapiens mRNA;cDNA DKFZp434F152 (from cloneDKFZp434F152), solute carrier family 5(sodium iodide symporter), member 5,solute carrier family 5 (sodium-dependent vitamin transporter), member 6258522972NM_145778eESTs, Highly similar to T08726 tubulinbeta chain [H. sapiens], ESTs, Highlysimilar to TBB1_RAT TUBULIN BETACHAIN (T BETA-15) [R. norvegicus],RIKEN cDNA 2410129E14 gene, RIKENcDNA 4930447K03 gene, RIKEN cDNA4930542G03 gene, Rat mRNA for beta-tubulin T beta15, expressed sequenceAI451582, expressed sequence C79445,tubulin, beta 3, tubulin, gamma 12449385NM_053885b, o, u, v,ESTs, Highly similar to T42731 atrophin-ee, ff, kk1 related protein - rat [R. norvegicus],ESTs, Weakly similar to dentatorubralpallidoluysian atrophy [M. musculus],arginine-glutamic acid dipeptide (RE)repeats, dentatorubral pallidoluysianatrophy, expressed sequenceAW556404, expressed sequenceAW742570120111346AI145991jj, kkESTs, Highly similar to T46266hypothetical protein DKFZp761A179.1[H. sapiens], KIAA1246 protein,KIAA1580 protein, hypothetical proteinFLJ1459444619411AA893667cc, ddESTs, Highly similar to T46904hypothetical protein DKFZp761D081.1[H. sapiens], Homo sapiens cDNA: FLJ21587 fis, clone COL06946, likelyortholog of mouse Arkadia48916753AA900474w, xESTs, Highly similar to T50619hypothetical protein DKFZp762M136.1[H. sapiens], hypothetical proteinDKFZp762M136219211628NM_024383bESTs, Highly similar toTRANSCRIPTION FACTOR HES-5[M. musculus], hairy and enhancer of split(Drosophila) homolog 2, hairy andenhancer of split 5, (Drosophila)253616456NM_134346iiESTs, Highly similar to TVHUR1transforming protein rap1b [H. sapiens],ESTs, Weakly similar to GTP-bindingprotein ROC2 [M. musculus], Musmusculus, Similar to RAS-like, estrogen-regulated, growth-inhibitor, cloneMGC: 31467 IMAGE: 4483442, mRNA,complete cds, RAP1B, member of RASoncogene family, RAP2B, member ofRAS oncogene family, RAS-like,estrogen-regulated, growth-inhibitor225615052NM_031136c, w, x,ESTs, Highly similar to TYB4 MOUSEaa, bbTHYMOSIN BETA-4 [M. musculus],ESTs, Moderately similar to PC4259ferritin associated protein [H. sapiens],Homo sapiens cDNA FLJ31414 fis, cloneNT2NE2000260, weakly similar toTHYMOSIN BETA-4, thymosin, beta 4, Xchromosome120211363AI145997hhESTs, Highly similar to UV EXCISIONREPAIR PROTEIN PROTEIN RAD23HOMOLOG B [M. musculus], RAD23homolog B (S. cerevisiae), RAD23bhomolog (S. cerevisiae)242814015NM_053770hhESTs, Moderately similar to Arg/Abl-interacting protein ArgBP2 [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to Arg/Abl-interactingprotein ArgBP2 [Rattus norvegicus][R. norvegicus], RIKEN cDNA2010203O03 gene, SH3-domain protein5 (ponsin), sorbin and SH3 domaincontaining 1242814017NM_053770hhESTs, Moderately similar to Arg/Abl-interacting protein ArgBP2 [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to Arg/Abl-interactingprotein ArgBP2 [Rattus norvegicus][R. norvegicus], RIKEN cDNA2010203O03 gene, SH3-domain protein5 (ponsin), sorbin and SH3 domaincontaining 11693381L00124b, l, mESTs, Moderately similar to elastase3B, pancreatic [Mus musculus][M. musculus], ESTs, Weakly similar toEL2 MOUSE ELASTASE 2PRECURSOR [M. musculus], ESTs,Weakly similar to EL2_RAT Elastase 2precursor [R. norvegicus], elastase 2,elastase 2A, elastase 3A, pancreatic(protease E), elastase 3B, pancreatic222217727NM_031043cESTs, Moderately similar to glycogenin2 [Homo sapiens] [H. sapiens],glycogenin, glycogenin 1, glycogenin 221389541NM_022542e, rESTs, Moderately similar to rhoB gene[Rattus norvegicus] [R. norvegicus],ESTs, Weakly similar to rhoB gene[Rattus norvegicus] [R. norvegicus], Musmusculus, clone MGC: 29297IMAGE: 5003249, mRNA, complete cds,RIKEN cDNA 5830400A04 gene, rashomolog B (RhoB), ras homolog genefamily, member B78221596AI009168j, kESTs, Moderately similar to rhoB gene[Rattus norvegicus] [R. norvegicus], Musmusculus, clone MGC: 29297IMAGE: 5003249, mRNA, complete cds,RIKEN cDNA 5830400A04 gene, celldivision cycle 42 homolog (S.cerevisiae), ras homolog B (RhoB), rashomolog gene family, member B, rashomolog gene family, member U, rhoBgene234818898NM_031985iiESTs, Moderately similar to ribosomalprotein S6 kinase, 70 kD, polypeptide 2;S6 kinase 2 [Mus musculus][M. musculus], RIKEN cDNA 2610318I15gene, ribosomal protein S6 kinase,70 kD, polypeptide 1, ribosomal proteinS6 kinase, 70 kD, polypeptide 2234818899NM_031985ggESTs, Moderately similar to ribosomalprotein S6 kinase, 70 kD, polypeptide 2;S6 kinase 2 [Mus musculus][M. musculus], RIKEN cDNA 2610318I15gene, ribosomal protein S6 kinase,70 kD, polypeptide 1, ribosomal proteinS6 kinase, 70 kD, polypeptide 221516934AA851403bESTs, Moderately similar to RIKENcDNA 2900010I05 [Mus musculus][M. musculus], NADH dehydrogenase(ubiquinone) 1 beta subcomplex, 8(19 kD, ASHI), RIKEN cDNA 2900010I05gene2157194NM_022861cc, ddESTs, Moderately similar to UNC-13homolog (C. elegans) 1 [Mus musculus][M. musculus], unc-13-like (C. elegans),unc13 homolog (C. elegans) 1124517783AI171206ee, ffESTs, Moderately similar to 2118320Aneurodegeneration-associated protein 1[Rattus norvegicus] [R. norvegicus],KIAA0438 gene product, Mus musculus,clone IMAGE: 3499845, mRNA, partialcds, hypothetical protein FLJ20552,hypothetical protein LOC51255, praja 1,praja1, RING-H2 motif containing, roteincarrying the RING-H2 sequence motif,similar to RIKEN cDNA 1300002C13,zinc finger protein 364195920702NM_017166j, k, y, zESTs, Moderately similar to A40936stathmin [H. sapiens], expressedsequence AI131641, leukemia-associated gene, stathmin 1/oncoprotein1818451467NM_013010iiESTs, Moderately similar to AAKG_RAT5′-AMP-activated protein kinase, gamma-1 subunit (AMPK gamma-1 chain)(AMPKg) [R. norvegicus], Mus musculus,clone MGC: 18882 IMAGE: 4238045,mRNA, complete cds, RIKEN cDNA2410051C13 gene, expressed sequenceAI854673, expressed sequenceBB036179, protein kinase, AMP-activated, gamma 1 non-catalytic subunit4137148AA892842f, gESTs, Moderately similar toCAZ3_MOUSE F-ACTIN CAPPINGPROTEIN ALPHA-3 SUBUNIT (CAPZALPHA-3) (GERM CELL-SPECIFICPROTEIN 3) [M. musculus], cappingprotein (actin filament) muscle Z-line,alpha 2, capping protein alpha 2,capping protein alpha 311034102AI102524ggESTs, Moderately similar toCBX4_HUMAN CHROMOBOXPROTEIN HOMOLOG 4 (POLYCOMB 2HOMOLOG) (PC2) (HPC2) [H. sapiens],chromobox homolog 4 (Pc classhomolog, Drosophila), hypotheticalprotein MGC10561222979NM_031079y, z, ee,ESTs, Moderately similar to CGMP-ffDEPENDENT 3′, 5′-CYCLICPHOSPHODIESTERASE [R. norvegicus],Mus musculus, Similar to cyclic GMPstimulated phosphodiesterase, cloneIMAGE: 3598413, mRNA, partial cds,phosphodiesterase 10A,phosphodiesterase 2A, cGMP-stimulated159318854AI237636f, g, l, mESTs, Moderately similar toCNE6_MOUSE COPINE VI(NEURONAL-COPINE) (N-COPINE)[M. musculus], ESTs, Weakly similar toCNE3_HUMAN COPINE III [H. sapiens],RIKEN cDNA 3632411M23 gene, copine6, copine II, copine III, expressedsequence AU067659, expressedsequence AW047065132313339AI176308s, tESTs, Moderately similar to CO1B_RATCoronin 1B (Coronin 2) [R. norvegicus],Mus musculus, Similar to coronin, actinbinding protein, 2A, cloneIMAGE: 4984475, mRNA, partial cds,coronin, actin binding protein 1B,coronin, actin binding protein 1C,hypothetical protein DKFZp762I166117917402AI137553ee, ffESTs, Moderately similar toDIP_HUMAN DIP PROTEIN [H. sapiens],KIAA0669 gene product, RIKEN cDNA0610009M14 gene, RIKEN cDNA1810043J12 gene, TSC-22-like,transforming growth factor beta 1induced transcript 4, transforming growthfactor beta-stimulated protein TSC-22185417401NM_013043a, p, q, z,ESTs, Moderately similar toee, ff, kkDIP_HUMAN DIP PROTEIN [H. sapiens],KIAA0669 gene product, RIKEN cDNA0610009M14 gene, RIKEN cDNA1810043J12 gene, TSC-22-like,transforming growth factor beta 1induced transcript 4, transforming growthfactor beta-stimulated protein TSC-22265216715X53054cc, dd, iiESTs, Moderately similar to HB2D_RATRT1 CLASS II HISTOCOMPATIBILITYANTIGEN, D-1 BETA CHAINPRECURSOR [R. norvegicus], ESTs,Weakly similar to HB2D_RAT RT1CLASS II HISTOCOMPATIBILITYANTIGEN, D-1 BETA CHAINPRECURSOR [R. norvegicus], Rattusnorvegicus Class II MHC RT1.D(a) betachain precursor (RT1.D(a)) mRNA,complete cds, Rattus norvegicus Class IIMHC RT1.D(n) beta chain precursor(RT1.D(n)) mRNA, complete cds, majorhistocompatibility complex, class II, DRbeta 5265216716X53054cESTs, Moderately similar to HB2D_RATRT1 CLASS II HISTOCOMPATIBILITYANTIGEN, D-1 BETA CHAINPRECURSOR [R. norvegicus], ESTs,Weakly similar to HB2D_RAT RT1CLASS II HISTOCOMPATIBILITYANTIGEN, D-1 BETA CHAINPRECURSOR [R. norvegicus], Rattusnorvegicus Class II MHC RT1.D(a) betachain precursor (RT1.D(a)) mRNA,complete cds, Rattus norvegicus Class IIMHC RT1.D(n) beta chain precursor(RT1.D(n)) mRNA, complete cds, majorhistocompatibility complex, class II, DRbeta 538218209AA892318s, tESTs, Moderately similar to JC7220nuclear protein SR-25 [H. sapiens], HSVIbinding protein, SRp25 nuclear protein,expressed sequence AA408210,expressed sequence AA4083658547120AI012393vESTs, Moderately similar to JE0343 terfprotein - rat [R. norvegicus], ESTs,Weakly similar to BUTY MOUSEBUTYROPHILIN PRECURSOR[M. musculus], ESTs, Weakly similar toJE0343 terf protein - rat [R. norvegicus],butyrophilin, subfamily 1, member A1,expressed sequence AA414909,expressed sequence AW538890, retfinger protein, tripartite motif protein 17,tripartite motif-containing 17248515460NM_057191d, ee, ffESTs, Moderately similar toKHL1_MOUSE Kelch-like protein 1[M. musculus], ESTs, Weakly similar toENC1_MOUSE ECTODERM-NEURALCORTEX-1 PROTEIN (ENC-1)[M. musculus], ESTs, Weakly similar toKRP1_RAT Kelch-related protein 1 (Kel-like protein 23) (Sarcosin)[R. norvegicus], KIAA1842 protein, Musmusculus, clone MGC: 28950IMAGE: 4235202, mRNA, complete cds,RIKEN cDNA 1300013C10 gene,expressed sequence AL022703, kelch-like 1 (Drosophila), sarcomeric muscleprotein, speckle-type POZ protein248515461NM_057191ee, ffESTs, Moderately similar toKHL1_MOUSE Kelch-like protein 1[M. musculus], ESTs, Weakly similar toENC1_MOUSE ECTODERM-NEURALCORTEX-1 PROTEIN (ENC-1)[M. musculus], ESTs, Weakly similar toKRP1_RAT Kelch-related protein 1 (Kel-like protein 23) (Sarcosin)[R. norvegicus], KIAA1842 protein, Musmusculus, clone MGC: 28950IMAGE: 4235202, mRNA, complete cds,RIKEN cDNA 1300013C10 gene,expressed sequence AL022703, kelch-like 1 (Drosophila), sarcomeric muscleprotein, speckle-type POZ protein14158180AI180353hhESTs, Moderately similar toLYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE PRECURSOR [H. sapiens],ESTs, Moderately similar to LYOX_RATProtein-lysine 6-oxidase precursor (Lysyloxidase) [R. norvegicus], Lysyl oxidase,lysyl oxidase, lysyl oxidase-like 2, lysyloxidase-like 411422386AA800844gESTs, Moderately similar toLYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE PRECURSOR [H. sapiens],ESTs, Weakly similar to LYOX_RATProtein-lysine 6-oxidase precursor (Lysyloxidase) [R. norvegicus], Lysyl oxidase,lysyl oxidase, lysyl oxidase-like, lysyloxidase-like 1, lysyl oxidase-like 225222385AA859805g, s, tESTs, Moderately similar toLYOX_HUMAN PROTEIN-LYSINE 6-OXIDASE PRECURSOR [H. sapiens],ESTs, Weakly similar to LYOX_RATProtein-lysine 6-oxidase precursor (Lysyloxidase) [R. norvegicus], Lysyl oxidase,lysyl oxidase, lysyl oxidase-like, lysyloxidase-like 1, lysyl oxidase-like 217878829NM_012749j, k, hh,ESTs, Moderately similar to NUCLEOLINkk[M. musculus], ESTs, Weakly similar toA35804 nucleolin [H. sapiens], ESTs,Weakly similar to NUCL_HUMANNUCLEOLIN [H. sapiens], ESTs, Weaklysimilar to NUCL_RAT Nucleolin (ProteinC23) [R. norvegicus], RIKEN cDNA1200009A02 gene, eukaryotic translationinitiation factor 3, subunit 4 (delta, 44 kDa),nucleolin, pigpen148323304AI231310ee, ffESTs, Moderately similar to P4H1_RATProlyl 4-hydroxylase alpha-1 subunitprecursor (4-PH alpha-1) (Procollagen-proline, 2-oxoglutarate-4-dioxygenasealpha-1 subunit) [R. norvegicus], Homosapiens, clone IMAGE: 3162218, mRNA,partial cds, RIKEN cDNA 4933406E20gene, procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide,procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase),alpha II polypeptide, procollagen-proline,2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I,procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase),alpha polypeptide II153615685AI233870hhESTs, Moderately similar to PAB1MOUSE POLYADENYLATE-BINDINGPROTEIN 1 [M. musculus], ESTs,Weakly similar to PAB1 MOUSEPOLYADENYLATE-BINDING PROTEIN1 [M. musculus], RIKEN cDNA4932702K14 gene, poly A bindingprotein, cytoplasmic 1, poly(A) bindingprotein, cytoplasmic 4 (inducible form)16631884D50695s, tESTs, Moderately similar toPRS6_HUMAN 26S PROTEASEREGULATORY SUBUNIT 6B[H. sapiens], proteasome (prosome,macropain) 26S subunit, ATPase, 48626489AI012636llESTs, Moderately similar to RBMA_RATRNA-BINDING PROTEIN 10 (RNABINDING MOTIF PROTEIN 10) (S1-1PROTEIN) [R. norvegicus], Homosapiens cDNA FLJ10100 fis, cloneHEMBA1002469, moderately similar toDXS8237E PROTEIN, Mus musculus,Similar to RNA binding motif protein 10,clone MGC: 7826 IMAGE: 3500403,mRNA, complete cds, RNA binding motifprotein 10, S1-1 protein from liver169114968K02815cESTs, Moderately similar to S04363class II histocompatibility antigen RT1-Balpha chain precursor - rat[R. norvegicus], histocompatibility 2, Oregion alpha locus, majorhistocompatibility complex, class II, DOalpha4833903AA899986w, xESTs, Moderately similar to S15552polypyrimidine tract-binding protein 1 -rat [R. norvegicus], ESTs, Weakly similarto S15552 polypyrimidine tract-bindingprotein 1 - rat [R. norvegicus], Musmusculus, Similar to regulator ofdifferentiation (in S. pombe) 1, cloneMGC: 11742 IMAGE: 3969488, mRNA,complete cds, RIKEN cDNA 2810036L13gene, heterogeneous nuclearribonucleoprotein L, polypyrimidine tractbinding protein 1, polypyrimidine tractbinding protein 211203905AI103403aESTs, Moderately similar to S15552polypyrimidine tract-binding protein 1 -rat [R. norvegicus], ESTs, Weakly similarto S15552 polypyrimidine tract-bindingprotein 1 - rat [R. norvegicus], Musmusculus, Similar to regulator ofdifferentiation (in S. pombe) 1, cloneMGC: 11742 IMAGE: 3969488, mRNA,complete cds, RIKEN cDNA 2810036L13gene, heterogeneous nuclearribonucleoprotein L, polypyrimidine tractbinding protein 1, polypyrimidine tractbinding protein 221263900NM_022516s, tESTs, Moderately similar to S15552polypyrimidine tract-binding protein 1 -rat [R. norvegicus], ESTs, Weakly similarto S15552 polypyrimidine tract-bindingprotein 1 - rat [R. norvegicus], Musmusculus, Similar to regulator ofdifferentiation (in S. pombe) 1, cloneMGC: 11742 IMAGE: 3969488, mRNA,complete cds, RIKEN cDNA 2810036L13gene, heterogeneous nuclearribonucleoprotein L, polypyrimidine tractbinding protein 1, polypyrimidine tractbinding protein 221263904NM_022516aa, bb, llESTs, Moderately similar to S15552polypyrimidine tract-binding protein 1 -rat [R. norvegicus], ESTs, Weakly similarto S15552 polypyrimidine tract-bindingprotein 1 - rat [R. norvegicus], Musmusculus, Similar to regulator ofdifferentiation (in S. pombe) 1, cloneMGC: 11742 IMAGE: 3969488, mRNA,complete cds, RIKEN cDNA 2810036L13gene, heterogeneous nuclearribonucleoprotein L, polypyrimidine tractbinding protein 1, polypyrimidine tractbinding protein 29467961AI044042l, mESTs, Moderately similar to S47073finger protein HZF2, Krueppel-related[H. sapiens], zinc finger protein 191, zincfinger protein 354A, zinc finger protein354B63822596AA955298y, zESTs, Moderately similar to T46637transcription factor 1, neural - rat[R. norvegicus], ESTs, Weakly similar toA35804 nucleolin [H. sapiens], Homosapiens mRNA; cDNA DKFZp434E0922(from clone DKFZp434E0922), Musmusculus 10, 11 days embryo wholebody cDNA, RIKEN full-length enrichedlibrary, clone: 2810003I18: myelintranscription factor 1-like, full insertsequence, myelin transcription factor 1-like, nucleolin252010660NM_133423e, cc, ddESTs, Moderately similar to T46637transcription factor 1, neural - rat[R. norvegicus], Homo sapiens mRNA;cDNA DKFZp434E0922 (from cloneDKFZp434E0922), Mus musculus 10, 11days embryo whole body cDNA, RIKENfull-length enriched library,clone: 2810003I18: myelin transcriptionfactor 1-like, full insert sequence, myelintranscription factor 1-like102010277AI059925u, vESTs, Moderately similar to T47137hypothetical protein DKFZp761K2213.1[H. sapiens], myeloid/lymphoid or mixedlineage-leukemia translocation to 4homolog (Drosophila), myeloid/lymphoidor mixed-lineage leukemia (trithoraxhomolog, Drosophila); translocated to, 48347060AI011547bESTs, Moderately similar to T47183hypothetical protein DKFZp434K1822.1[H. sapiens], ubiquitin specific protease22254925479NM_138549jj, kkESTs, Moderately similar to T50638synaptic glycoprotein SC2 [H. sapiens],ESTs, Weakly similar to T50638 synapticglycoprotein SC2 [H. sapiens], expressedsequence AI173355, glycoprotein,synaptic 2, steroid 5 alpha-reductase 2,steroid 5 alpha-reductase 2-like, steroid5-alpha-reductase 2, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5alpha-steroid delta 4-dehydrogenasealpha 2)11821416AA800962hhESTs, Moderately similar to TALIN[M. musculus], Mus musculus, Similar tohypothetical protein MGC11134, cloneMGC: 41710 IMAGE: 1364225, mRNA,complete cds, talin, talin 217741514NM_012678bbESTs, Moderately similar toTROPOMYOSIN 5, CYTOSKELETALTYPE [M. musculus], tropomyosin 45024858AA901238w, xESTs, Moderately similar toUBC6_HUMAN UBIQUITIN-CONJUGATING ENZYME E2-21 KDUBCH6 [H. sapiens], ESTs, Weaklysimilar to S53358 ubiquitin-conjugatingenzyme E2.17 kB - rat [R. norvegicus],Homo sapiens cDNA FLJ25157 fis, cloneCBR08008, highly similar to UBIQUITIN-CONJUGATING ENZYME E2-23 KDA(EC 6.3.2.19), Mus musculus, Similar toubiquitin-conjugating enzyme E2E 3(homologous to yeast UBC4/5), cloneMGC: 28917 IMAGE: 4923869, mRNA,complete cds, RIKEN cDNA1100001F19 gene, RIKEN cDNA1600028I17 gene, RIKEN cDNA6130401J04 gene, hypothetical proteinFLJ11011, ubiquitin-conjugating enzymeE2D 3 (UBC4/5 homolog, yeast),ubiquitin-conjugating enzyme E2D 3(homologous to yeast UBC4/5), ubiquitin-conjugating enzyme E2E 1 (UBC4/5homolog, yeast), ubiquitin-conjugatingenzyme E2E 2 (UBC4/5 homolog, yeast)211523300NM_022398jj, kkESTs, Weakly similar to 2-oxoglutaratecarrier [Rattus norvegicus][R. norvegicus], solute carrier family 25(mitochondrial carrier; adeninenucleotide translocator), member 10,solute carrier family 25 (mitochondrialcarrier; oxoglutarate carrier), member 11221325517NM_031010c, vESTs, Weakly similar to arachidonate12-lipoxygenase [Rattus norvegicus][R. norvegicus], arachidonate 12-lipoxygenase, arachidonate 12-lipoxygenase, pseudogene 2,arachidonate 15-lipoxygenase22131845NM_031010c, vESTs, Weakly similar to arachidonate12-lipoxygenase [Rattus norvegicus][R. norvegicus], arachidonate 12-lipoxygenase, arachidonate 12-lipoxygenase, pseudogene 2,arachidonate 15-lipoxygenase25474422NM_138531ggESTs, Weakly similar to associatedmolecule with the SH3 domain of STAM[Homo sapiens] [H. sapiens], RIKENcDNA 1700095N21 gene, associatedmolecule with the SH3 domain of STAM208419667NM_021690iiESTs, Weakly similar to Cgef2-pending;cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII[Mus musculus] [M. musculus], Musmusculus, Similar to cAMP-regulatedguanine nucleotide exchange factor I(cAMP-GEFI), clone MGC: 19192IMAGE: 4236136, mRNA, complete cds,RIKEN cDNA 4921517L17 gene, Rap1guanine-nucleotide-exchange factordirectly activated by cAMP, cAMP-regulated guanine nucleotide exchangefactor II, chromosome 20 open readingframe 152, expressed sequence C8612061120619AA945737d, r, aa,ESTs, Weakly similar to CXCbbchemokine receptor [Rattus norvegicus][R. norvegicus], G protein-coupledreceptor, chemokine (C-X-C motif),receptor 4 (fusin), chemokine (C-X-C)receptor 4209720249NM_022205IIESTs, Weakly similar to CXCchemokine receptor [Rattus norvegicus][R. norvegicus], G protein-coupledreceptor, chemokine (C-X-C motif),receptor 4 (fusin), chemokine (C-X-C)receptor 412236969AI170244hhESTs, Weakly similar to g1-related zincfinger protein [Mus musculus][M. musculus], Homo sapiens, cloneIMAGE: 3956746, mRNA, partial cds, g1-related zinc finger protein, similar toRIKEN cDNA 1300002C1311025969AI102520b, l, m,ESTs, Weakly similar to GABA(A)bb, kkreceptor-associated protein like 2;ganglioside expression factor 2 [Rattusnorvegicus] [R. norvegicus], GABA(A)receptor-associated protein, GABA(A)receptor-associated protein like 1,GABA(A) receptor-associated proteinlike 2, GABA(A) receptor-associatedprotein-like 2, GABA(A) receptorsassociated protein like 3, gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1, gamma-aminobutyric acid receptor associatedprotein89515904AI013971l, mESTs, Weakly similar to L1 celladhesion molecule [Mus musculus][M. musculus], ESTs, Weakly similar toA41060 neural cell adhesion moleculeL1 precursor [H. sapiens], ESTs, Weaklysimilar to S36126 neural cell adhesionmolecule L1 - rat [R. norvegicus], L1 celladhesion molecule, L1 cell adhesionmolecule (hydrocephalus, stenosis ofaqueduct of Sylvius 1, MASA (mentalretardation, aphasia, shuffling gait andadducted thumbs) syndrome, spasticparaplegia 1), close homolog of L1,neuronal cell adhesion molecule211318221NM_022395cc, ddESTs, Weakly similar to mitochondrialprocessing peptidase beta [Rattusnorvegicus] [R. norvegicus], RIKENcDNA 3110004O18 gene, mitochondrialprocessing peptidase beta, peptidase(mitochondrial processing) beta,ubiquinol-cytochrome c reductase coreprotein 1, ubiquinol-cytochrome creductase core protein I240321445NM_053587a, e, y, z,ESTs, Weakly similar to S100 calcium-ee, ffbinding protein A9 (calgranulin B);intracellular calcium-binding protein(MRP14) [Rattus norvegicus][R. norvegicus], S100 calcium bindingprotein A13, S100 calcium bindingprotein A7 (psoriasin 1), S100 calciumbinding protein A9 (calgranulin B)210618246NM_022300hhESTs, Weakly similar to Ser/Arg-relatednuclear matrix protein; plenty-of-prolines-101; serine/arginine repetitive matrixprotein 1 [Mus musculus] [M. musculus],Mus musculus, Similar to hypotheticalprotein MGC13125, clone MGC: 38070IMAGE: 5252666, mRNA, complete cds,brain abundant, membrane attachedsignal protein 1, expressed sequenceAI480556, glucocorticoid-induced gene1, serine/arginine repetitive matrix 1234919768NM_031986f, g, cc,ESTs, Weakly similar to syntenindd[Rattus norvegicus] [R. norvegicus],syndecan binding protein, syndecanbinding protein (syntenin), syndecanbinding protein (syntenin) 2243620421NM_053821f, iiESTs, Weakly similar to v-ral simianleukemia viral oncogene homolog B (rasrelated) [Rattus norvegicus][R. norvegicus], v-ral simian leukemiaviral oncogene homolog B (ras related),v-ral simian leukemia viral oncogenehomolog B (ras related; GTP bindingprotein)1877749AA848804kkESTs, Weakly similar to 1607338Atranscription factor BTF3a [H. sapiens],Mus musculus, basic transcription factor3, clone MGC: 6799 IMAGE: 2648048,mRNA, complete cds, RIKEN cDNA1700054E11 gene, RIKEN cDNA5730434I03 gene, basic transcriptionfactor 315622687AI235877s, tESTs, Weakly similar to 2019405Aupstream regulator element-bindingprotein [Rattus norvegicus][R. norvegicus], Mus musculus, cloneMGC: 12070 IMAGE: 3708271, mRNA,complete cds, RIKEN cDNA1110018G07 gene, RIKEN cDNA2810411E22 gene, RIKEN cDNA4432411E13 gene, RIKEN cDNA4930431E10 gene, expressed sequenceAW212605, upstream regulatory elementbinding protein 122108815NM_030991aa, bbESTs, Weakly similar to 2122252A Lasp-1 protein [H. sapiens], LIM and SH3protein 1, RIKEN cDNA 1200007O21gene2481919NM_057125l, mESTs, Weakly similar to 2204387Aperoxisome assembly factor 2 [Rattusnorvegicus] [R. norvegicus], ESTs,Weakly similar to TRANSITIONALENDOPLASMIC RETICULUM ATPASE[M. musculus], RIKEN cDNA4833413G10 gene, expressed sequenceAI195026, peroxisomal biogenesis factor6, peroxisome biogenesis factor 1,valosin containing protein154918444AI234915iiESTs, Weakly similar to A26882 pIL2hypothetical protein - rat [R. norvegicus],ESTs, Weakly similar to AF191020 1E2IG5 [H. sapiens], RIKEN cDNA2310056P07 gene, RIKEN cDNA9430073N08 gene, hypothetical protein,estradiol-induced243916099NM_053837f, r, cc,ESTs, Weakly similar to A2M1_HUMANddClathrin coat assembly protein AP50(Clathrin coat associated protein AP50)(Plasma membrane adaptor AP-2 50 kDaprotein) (HA2 50 kDa subunit)(Clathrin assembly protein complex 2medium chain) (AP-2 mu 2 chain)[R. norvegicus], adaptor protein complexAP-1, mu 2 subunit, adaptor proteincomplex AP-2, mu1, adaptor-relatedprotein complex 1, mu 2 subunit, adaptor-related protein complex 2, mu 1 subunit,adaptor-related protein complex AP-1,mu subunit 1, adaptor-related proteincomplex AP-4, mu 1, stonin 210617997AA800671uESTs, Weakly similar to A54854 RasGTPase activating protein-relatedprotein [H. sapiens]244518357NM_053864n, oESTs, Weakly similar to A55190transitional endoplasmic reticulumATPase (EC 3.6.1.—) [validated] - rat[R. norvegicus], ESTs, Weakly similar toTRANSITIONAL ENDOPLASMICRETICULUM ATPASE [M. musculus],Homo sapiens spermatogenesisassociated factor (SPAF) mRNA,complete cds, RIKEN cDNA4833413G10 gene, RIKEN cDNA4933439B08 gene, expressed sequenceAI195026, katanin p60 (ATPase-containing) subunit A1, nuclear VCP-like,peroxisome biogenesis factor 1,spermatogenesis associated factor,valosin containing protein, valosin-containing protein2108695NM_022388u, vESTs, Weakly similar to A55571 chlorideconductance inducer Mat-8 [H. sapiens],FXYD domain-containing ion transportregulator 3, FXYD domain-containing iontransport regulator 4211223061NM_022394s, tESTs, Weakly similar to A55817 cyclin-dependent kinase p130-PITSLRE -mouse [M. musculus], RIKEN cDNA2600011L02 gene, RIKEN cDNAA930036K24 gene, aldehydedehydrogenase family 5, subfamily A1,cell division cycle 2 homolog (S. pombe)-like 2, expressed sequence AI255170,scaffold attachment factor B165419053D12770aa, bbESTs, Weakly similar to ADT1 MOUSEADP, ATP CARRIER PROTEIN,HEART/SKELETAL MUSCLE ISOFORMT1 [M. musculus], Mus musculus, Similarto RIKEN cDNA 1700066C05 gene,clone MGC: 28125 IMAGE: 3980327,mRNA, complete cds, RIKEN cDNA1700034J06 gene, solute carrier family25 (mitochondrial carrier, Aralar),member 12, solute carrier family 25(mitochondrial carrier; adeninenucleotide translocator), member 421006263NM_022251jj, kkESTs, Weakly similar to AMPE MOUSEGLUTAMYL AMINOPEPTIDASE[M. musculus], aminopeptidasepuromycin sensitive, glutamylaminopeptidase, glutamylaminopeptidase (aminopeptidase A),puromycin-sensitive aminopeptidase157515051AI236332j, k, p, q,ESTs, Weakly similar to ATDA_HUMANy, z, ee,DIAMINE ACETYLTRANSFERASEff[H. sapiens], RIKEN cDNA 2610016A03gene, spermidine/spermine N1-acetyltransferase132216438AI176294cc, ddESTs, Weakly similar to B Chain B,Crystal Structure Of The D1d2 Sub-Complex From The Human Snrnp CoreDomain [H. sapiens]251919326NM_133419u, v, jj,ESTs, Weakly similar to B41182kkcollagen alpha 1(II) chain precursor[M. musculus], PUMA/JFY1 protein,RIKEN cDNA 4933407C03 gene, RIKENcDNA 5730512J02 gene, dyskeratosiscongenita 1, dyskerin242215269NM_053739d, f, gESTs, Weakly similar to BCN1_MOUSEBeclin 1 (Coiled-coil myosin-like BCL2-interacting protein) [M. musculus], RIKENcDNA 4921513J16 gene, beclin 1 (coiled-coil, myosin-like BCL2 interactingprotein), beclin 1 (coiled-coil, myosin-likeBCL2-interacting protein)237916017NM_053401o, aaESTs, Weakly similar to C35826hypothetical 13K protein A [H. sapiens], Xlinked protein, brain expressed X-linked2, nerve growth factor receptor(TNFRSF16) associated protein 1,reduced expression 3237916018NM_053401b, cESTs, Weakly similar to C35826hypothetical 13K protein A [H. sapiens], Xlinked protein, brain expressed X-linked2, nerve growth factor receptor(TNFRSF16) associated protein 1,reduced expression 3217023215NM_023102b, l, mESTs, Weakly similar to casein kinase[M. musculus], RIKEN cDNA2610208K14 gene, RIKEN cDNA3300002K07 gene, VRK3 for vacciniarelated kinase 3, casein kinase 1, alpha1, casein kinase 1, delta, casein kinase1, gamma 21584491AA818798w, xESTs, Weakly similar to CATZ_HUMANCathepsin Z precursor (Cathepsin X)(Cathepsin P) [H. sapiens], cathepsin Z,expressed sequence AU0198192104490AA851184n, oESTs, Weakly similar to CATZ_HUMANCathepsin Z precursor (Cathepsin X)(Cathepsin P) [H. sapiens], cathepsin Z,expressed sequence AU01981961920832AA946040hhESTs, Weakly similar to COXG MOUSECYTOCHROME C OXIDASEPOLYPEPTIDE VIB [M. musculus], Homosapiens, hypothetical gene LOC125965,clone MGC: 33640 IMAGE: 4827471,mRNA, complete cds219525070NM_024392r, iiESTs, Weakly similar to DHB4 MOUSEESTRADIOL 17 BETA-DEHYDROGENASE 4 [M. musculus],ESTs, Weakly similar to DHB4_HUMANESTRADIOL 17 BETA-DEHYDROGENASE 4 [H. sapiens],RIKEN cDNA 1110029G07 gene, RIKENcDNA 1700010M22 gene, RIKEN cDNA3110069K09 gene, hydroxysteroid (17-beta) dehydrogenase 42413857NM_053633y, z, ee,ESTs, Weakly similar to EGR2 MOUSEffEARLY GROWTH RESPONSEPROTEIN 2 [M. musculus], MYC-associated zinc finger protein (purine-binding transcription factor), early growthresponse 2, early growth response 2(Krox-20 homolog, Drosophila)168917136J04035f, aa, bbESTs, Weakly similar to ELS MOUSEELASTIN PRECURSOR [M. musculus],RIKEN cDNA 4930554K12 gene, elastin,elastin (supravalvular aortic stenosis,Williams-Beuren syndrome)67024135AA957736n, oESTs, Weakly similar to FIBULIN-1,ISOFORM C PRECURSOR[M. musculus], Homo sapiens cDNAFLJ23816 fis, clone HSI02685, Homosapiens cDNA FLJ32009 fis, cloneNT2RP7009498, weakly similar toFIBULIN-1, ISOFORM A PRECURSOR,Mus musculus mRNA for CRTAC1-Bprotein (CRTAC1 gene), RIKEN cDNA5730592L21 gene, fibulin 5249823551NM_080698iiESTs, Weakly similar to FMOD_HUMANFIBROMODULIN PRECURSOR[H. sapiens], fibromodulin, fibronectinleucine rich transmembrane protein 1,fibronectin leucine rich transmembraneprotein 2, fibronectin leucine richtransmembrane protein 3, hypotheticalprotein FLJ23447219015622NM_024369f, gESTs, Weakly similar to FRP MOUSEFOLLISTATIN-RELATED PROTEINPRECURSOR [M. musculus], follistatin-like, follistatin-like 1219015623NM_024369rESTs, Weakly similar to FRP MOUSEFOLLISTATIN-RELATED PROTEINPRECURSOR [M. musculus], follistatin-like, follistatin-like 111777122AI137468ggESTs, Weakly similar to GPV_RATPlatelet glycoprotein V precursor (GPV)(CD42D) [R. norvegicus], Plateleteglycoprotein 5, RIKEN cDNA1300018K11 gene, RIKEN cDNA2610528G05 gene, RIKEN cDNA5430427N11 gene, carboxypeptidase N,polypeptide 2, 83 kD, glycoprotein 5(platelet), glycoprotein V (platelet),hypothetical protein FLJ12568, leucine-rich alpha-2-glycoprotein263920818X02904iiESTs, Weakly similar to GTP_RATGlutathione S-transferase P (GST 7-7)(Chain 7) (GST class-pi) [R. norvegicus],Mus musculus, clone MGC: 37914IMAGE: 5102505, mRNA, complete cds,glutathione S-transferase pi, glutathioneS-transferase, pi 2204818761NM_019250aaESTs, Weakly similar to GUANINENUCLEOTIDE DISSOCIATIONSTIMULATOR RALGDS FORM A[M. musculus], ESTs, Weakly similar toT12453 hypothetical proteinDKFZp564D2123.1 [H. sapiens], RIKENcDNA 1300003D20 gene, RIKEN cDNA4930573C08 gene, RalGDS-like gene,ral guanine nucleotide dissociationstimulator, ral guanine nucleotidedissociation stimulator,-like 125739775NM_139334cESTs, Weakly similar to guaninenucleotide regulatory protein [H. sapiens],Rho guanine nucleotide exchange factor(GEF) 517521708NM_012581iiESTs, Weakly similar to HOMEOBOXPROTEIN HOX-A2 [M. musculus], evenskipped homeotic gene 2 homolog,expressed sequence AI894218, homeobox A11, homeo box A2, homeo box B217521709NM_012581l, mESTs, Weakly similar to HOMEOBOXPROTEIN HOX-A2 [M. musculus], evenskipped homeotic gene 2 homolog,expressed sequence AI894218, homeobox A11, homeo box A2, homeo box B216487602AJ001929f, aaESTs, Weakly similar to I56519 taipoxin-associated calcium binding protein-49precursor - rat [R. norvegicus], Homosapiens cDNA FLJ14474 fis, cloneMAMMA1001256, calumenin,reticulocalbin 1, EF-hand calciumbinding domain, reticulocalbin 2,reticulocalbin 2, EF-hand calciumbinding domain74111745AB006450hh, jj, kkESTs, Weakly similar to IM7A_RATMitochondrial import inner membranetranslocase subunit TIM17 A[R. norvegicus], translocase of innermitochondrial membrane 17 homolog A(yeast), translocase of innermitochondrial membrane 17 homolog B(yeast), translocator of innermitochondrial membrane 17 kDa, a238515556NM_053483kkESTs, Weakly similar to IMPORTINALPHA-2 SUBUNIT [M. musculus],karyopherin (importin) alpha 2,karyopherin (importin) alpha 3,karyopherin (importin) alpha 4,karyopherin alpha 2 (RAG cohort 1,importin alpha 1), karyopherin alpha 3(importin alpha 4), karyopherin alpha 4(importin alpha 3), karyopherin alpha 5(importin alpha 6)138516668AI178751iiESTs, Weakly similar to JC5251 beta-galactoside alpha-2,3-sialyltransferase[H. sapiens], sialyltransferase,sialyltransferase 4A (beta-galactosidasealpha-2,3-sialytransferase),sialyltransferase 4B (beta-galactosidasealpha-2,3-sialytransferase),sialyltransferase 5, sialyltransferase 7((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosamindealpha-2,6-sialyltransferase) A,sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) B, sialyltransferase 7D((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminidealpha-2,6-sialyltransferase)231316663NM_031695sESTs, Weakly similar to JC5251 beta-galactoside alpha-2,3-sialyltransferase[H. sapiens], sialyltransferase,sialyltransferase 4A (beta-galactosidasealpha-2,3-sialytransferase),sialyltransferase 4B (beta-galactosidasealpha-2,3-sialytransferase),sialyltransferase 5, sialyltransferase 7((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosamindealpha-2,6-sialyltransferase) A,sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) B, sialyltransferase 7D((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminidealpha-2,6-sialyltransferase)1716281AA819517hhESTs, Weakly similar to JC5707 HYA22protein [H. sapiens], hypothetical proteinBC01073612475953AI171231s, tESTs, Weakly similar to JC7328 aminoacid transporter A1 [H. sapiens], Homosapiens clone 24674 mRNA sequence,solute carrier family 38, member 1,solute carrier family 38, member 21817187NM_012903rESTs, Weakly similar to LANP_RATLeucine-rich acidic nuclear protein[R. norvegicus], acidic (leucine-rich)nuclear phosphoprotein 32 family,member A, acidic nuclearphosphoprotein 32, cerebellar ataxia 3,hypothetical gene MGC16309, smallnuclear ribonucleoprotein polypeptide A′232416003NM_031757cESTs, Weakly similar to MM24_MOUSEMATRIX METALLOPROTEINASE-24PRECURSOR (MMP-24) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE5) (MT-MMP 5) (MEMBRANE-TYPE-5MATRIX METALLOPROTEINASE) (MT5-MMP) (MMP-21) [M. musculus], matrixmetalloproteinase 17, matrixmetalloproteinase 19, matrixmetalloproteinase 24, matrixmetalloproteinase 24 (membrane-inserted)7471097AF016296e, j, k,ESTs, Weakly similar to NRP1_HUMANcc, dd,NEUROPILIN-1 PRECURSORkk[H. sapiens], neuropilin, neuropilin 1,platelet derived growth factor C24161316NM_053656s, t, iiESTs, Weakly similar to P2X6 MOUSEP2X PURINOCEPTOR 6 [M. musculus],purinergic receptor P2X, ligand-gated ionchannel, 2, purinergic receptor P2X,ligand-gated ion channel, 52450753NM_053897ee, ff, ggESTs, Weakly similar to PAR3 MOUSEPROTEINASE ACTIVATED RECEPTOR3 PRECURSOR [M. musculus],coagulation factor II (thrombin) receptor-like 1, coagulation factor II (thrombin)receptor-like 2239215829NM_053551e, n, o,ESTs, Weakly similar to PDK4_MOUSEp, q, r,[PYRUVATE DEHYDROGENASEaa, bb[LIPOAMIDE]] KINASE ISOZYME 4,MITOCHONDRIAL PRECURSOR(PYRUVATE DEHYDROGENASEKINASE ISOFORM 4) [M. musculus],pyruvate dehydrogenase kinase 4,pyruvate dehydrogenase kinase,isoenzyme 416651356D83538u, vESTs, Weakly similar to PK3G_RATPhosphatidylinositol 3-kinase C2 domain-containing gamma polypeptide(Phosphoinositide 3-Kinase-C2-gamma)(Ptdlns-3-kinase C2 gamma) (PI3K-C2gamma) [R. norvegicus], Homosapiens cDNA FLJ12591 fis, cloneNT2RM4001313, moderately similar toPHOSPHATIDYLINOSITOL 3-KINASEVPS34-LIKE (EC 2.7.1.137),phosphatidylinositol 3-kinase, C2 domaincontaining, gamma polypeptide,phosphatidylinositol 3-kinase, catalytic,alpha polypeptide, phosphatidylinositol 4-kinase, catalytic, beta polypeptide,phosphoinositide-3-kinase, class 2,gamma polypeptide259312700NM_152936h, lESTs, Weakly similar to PSG1 MOUSEPROSTATIC SECRETORYGLYCOPROTEIN PRECURSOR[M. musculus], RIKEN cDNA2310065D10 gene, serine proteaseinhibitor, Kazal type 1, serine proteaseinhibitor, Kazal type 32264239NM_031152eESTs, Weakly similar to R11A_HUMANRas-related protein Rab-11A (RAB-11)(24 KG) (YL8) [R. norvegicus], RAB11A,member RAS oncogene family, RAB11a,member RAS oncogene family, RAB25,member RAS oncogene family,expressed sequence AW496496224120807NM_031106f, gESTs, Weakly similar to R6RT37ribosomal protein L37, cytosolic[validated] - rat [R. norvegicus], RIKENcDNA 1500002F19 gene, RIKEN cDNA3110005M08 gene, ribosomal proteinL378927299AI013911tESTs, Weakly similar to RBM3 MOUSEPUTATIVE RNA-BINDING PROTEIN 3[M. musculus], Mus musculus adult maletongue cDNA, RIKEN full-lengthenriched library, clone: 2310074E15: RNAbinding motif protein 3, full insertsequence, RNA binding motif protein 3,RNA binding motif protein, Xchromosome, RNA binding motif protein,X chromosome retrogene, cold inducibleRNA binding protein, cold inducible RNA-binding protein14629412AI230691f, gESTs, Weakly similar to RL34_HUMAN60S RIBOSOMAL PROTEIN L34[H. sapiens], ESTs, Weakly similar toRL34_RAT 60S RIBOSOMAL PROTEINL34 [R. norvegicus], RIKEN cDNA1100001I22 gene, ribosomal protein L34128223390AI172328eESTs, Weakly similar to ROD_RATHeterogeneous nuclearribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)[R. norvegicus], Mus musculus , cloneMGC: 36467 IMAGE: 5359082, mRNA,complete cds, RIKEN cDNA4933434H11 gene, heterogeneousnuclear ribonucleoprotein D,heterogeneous nuclear ribonucleoproteinD (AU-rich element RNA binding protein1, 37 kD), heterogeneous nuclearribonucleoprotein D-like, high-glycine/tyrosine protein type I E5,musashi homolog 2 (Drosophila)99610070AI058505u, vESTs, Weakly similar to RRM1_HUMANPUTATIVE RIBOSOMAL RNAMETHYLTRANSFERASE 1 [H. sapiens],FtsJ homolog 2 (E. coli)6812211AA963834l, mESTs, Weakly similar to S105_MOUSES100 calcium-binding protein A5 (S-100D protein) [R. norvegicus], S100calcium binding protein A514331473AI228548aaESTs, Weakly similar to S10A MOUSE S-100 PROTEIN, ALPHA CHAIN[M. musculus], S100 calcium bindingprotein A1, S100 calcium binding proteinA11 (calizzarin), S100 calcium bindingprotein P, S100Z protein, expressedsequence AI26679523421475NM_031971a, p, q,ESTs, Weakly similar to S10A MOUSE S-ee, ff100 PROTEIN, ALPHA CHAIN[M. musculus], S100 calcium bindingprotein A1, S100 calcium binding proteinA11 (calizzarin), S100 calcium bindingprotein P, S100Z protein, expressedsequence AI26679539111992AA892485fESTs, Weakly similar to S21766dihydrolipoamide S-acetyltransferase(EC 2.3.1.12) - rat (fragment)[R. norvegicus], Mus musculus, cloneIMAGE: 3586777, mRNA, partial cds,Pyruvate dehydrogenase complex, lipoyl-containing component X; E3-bindingprotein, RIKEN cDNA 1600017E01gene, RIKEN cDNA 4930529O08 gene,dihydrolipoamide branched chaintransacylase (E2 component ofbranched chain keto aciddehydrogenase complex; maple syrupurine disease), dihydrolipoamidebranched chain transacylase E2,pyruvate dehydrogenase complex,component X16535049D10655g, w, cc,ESTs, Weakly similar to S21766dd, jj, kkdihydrolipoamide S-acetyltransferase(EC 2.3.1.12) - rat (fragment)[R. norvegicus], Mus musculus, cloneIMAGE: 3586777, mRNA, partial cds,Pyruvate dehydrogenase complex, lipoyl-containing component X; E3-bindingprotein, RIKEN cDNA 1600017E01gene, RIKEN cDNA 4930529O08 gene,dihydrolipoamide branched chaintransacylase (E2 component ofbranched chain keto aciddehydrogenase complex; maple syrupurine disease), dihydrolipoamidebranched chain transacylase E2,pyruvate dehydrogenase complex,component X16535050D10655f, g, cc,ESTs, Weakly similar to S21766dddihydrolipoamide S-acetyltransferase(EC 2.3.1.12) - rat (fragment)[R. norvegicus], Mus musculus, cloneIMAGE: 3586777, mRNA, partial cds,Pyruvate dehydrogenase complex, lipoyl-containing component X; E3-bindingprotein, RIKEN cDNA 1600017E01gene, RIKEN cDNA 4930529O08 gene,dihydrolipoamide branched chaintransacylase (E2 component ofbranched chain keto aciddehydrogenase complex; maple syrupurine disease), dihydrolipoamidebranched chain transacylase E2,pyruvate dehydrogenase complex,component X222515957NM_031050c, iiESTs, Weakly similar to S52284lumicon, secretory intersticialproteoglycan precursor - rat[R. norvegicus], dermatan sulfateproteoglycan 3, dermatan sulphateproteoglycan 3, lumican7562947AF099093u, vESTs, Weakly similar to S53358ubiquitin-conjugating enzyme E2.17 kB - rat [R. norvegicus], RIKEN cDNA1100001F19 gene, RIKEN cDNA1600028I17 gene, prefoldin 5, ubiquitin-conjugating enzyme E2D 3 (UBC4/5homolog, yeast), ubiquitin-conjugatingenzyme E2D 3 (homologous to yeastUBC4/5), ubiquitin-conjugating enzymeE2G 1 (UBC7 homolog, C. elegans)195313392NM_017148eESTs, Weakly similar to S53580cysteine-rich protein - rat [R. norvegicus],RIKEN cDNA 0610025L06 gene,cysteine and glycine-rich protein 1,cysteine rich protein5453997AA925771iiESTs, Weakly similar to T12483hypothetical protein DKFZp564B0769.1[H. sapiens], Homo sapiens, cloneMGC: 16721 IMAGE: 4128659, mRNA,complete cds, KIAA1604 protein, SR richprotein5918226AA799641lESTs, Weakly similar to T46332hypothetical protein DKFZp434H0413.1[H. sapiens], Homo sapiens, cloneMGC: 9709 IMAGE: 3850147, mRNA,complete cds, KIAA1253 protein,expressed sequence AW121759,expressed sequence C861237222757AA997851bb, llESTs, Weakly similar to TGR3_HUMANTGF-BETA RECEPTOR TYPE IIIPRECURSOR [H. sapiens], Homosapiens cDNA FLJ33157 fis, cloneUTERU2000393, endoglin9023625AI028954iiESTs, Weakly similar to TIE1 MOUSETYROSINE-PROTEIN KINASERECEPTOR TIE-1 PRECURSOR[M. musculus], Homo sapiens cDNA:FLJ23028 fis, clone LNG01852, highlysimilar to HSU08023 Human cellularproto-oncogene (c-mer) mRNA, RYKreceptor-like tyrosine kinase, c-mer proto-oncogene tyrosine kinase, receptor-liketyrosine kinase, tyrosine kinase receptor1, tyrosine kinase with immunoglobulinand epidermal growth factor homologydomains126211696AI171774jj, kkESTs, Weakly similar to TMOD MOUSETROPOMODULIN [M. musculus],leiomodin 2 (cardiac), tropomodulin14967036AI231801n, o, cc,ESTs, Weakly similar to TRANSITIONALddENDOPLASMIC RETICULUM ATPASE[M. musculus], Homo sapiensspermatogenesis associated factor(SPAF) mRNA, complete cds, RIKENcDNA 4833413G10 gene, RIKEN cDNA4933439B08 gene, expressed sequenceAI195026, katanin p60 (ATPase-containing) subunit A1, nuclear VCP-like,peroxisome biogenesis factor 1,spermatogenesis associated factor,valosin containing protein, valosin-containing protein247017431NM_054006cc, ddESTs, Weakly similar to UNR PROTEIN[R. norvegicus], Mus musculus, cloneMGC: 19174 IMAGE: 4224466, mRNA,complete cds, NRAS-related gene239411843NM_053555n, o, sESTs, Weakly similar to VAM5_HUMANVESICULE-ASSOCIATED MEMBRANEPROTEIN 5 (VAMP-5) (MYOBREVIN)(HSPC191) [H. sapiens], vesicle-associated membrane protein 5, vesicle-associated membrane protein 5(myobrevin)206152NM_019335dESTs, Weakly similar to WEE1 MOUSEWEE1-LIKE PROTEIN KINASE[M. musculus], NIMA (never in mitosisgene a)-related expressed kinase 4,eukaryotic translation initiation factor 2alpha kinase 2, protein kinase, interferon-inducible double stranded RNAdependent184424718NM_013003iiexpressed sequence AI255394,phosphatidylethanolamine N-methyltransferase92819257AI030775mexpressed sequence AI323765,histocompatibility 2, class II antigen Ealpha, major histocompatibility complex,class II, DR alpha170919255M15562cexpressed sequence AI323765,histocompatibility 2, class II antigen Ealpha, major histocompatibility complex,class II, DR alpha170919256M15562cexpressed sequence AI323765,histocompatibility 2, class II antigen Ealpha, major histocompatibility complex,class II, DR alpha10284967AI070179w, xexpressed sequence AI324845, gliamaturation factor, gamma245115706NM_053921llexpressed sequence AI451906,peroxisomal biogenesis factor 1217179223M36151cexpressed sequence AI845868,histocompatibility 2, class II antigen A,beta 1, major histocompatibility complex,class II, DO beta, majorhistocompatibility complex, class II, DQbeta 129816419AA875102dexpressed sequence AL022645,expressed sequence C76690, smallnuclear ribonucleoprotein E, smallnuclear ribonucleoprotein polypeptide E179320AA819905hhexpressed sequence AU022220,stearoyl-CoA desaturase (delta-9-desaturase), stearoyl-Coenzyme Adesaturase 1, stearoyl-coenzyme Adesaturase 312811166AA801346n, oexpressed sequence AU042020, plexinB1, plexin B2, plexin B325071809NM_130741l, kexpressed sequence AW212229,lipocalin 2 (oncogene 24p3)22541816NM_031134l, mexpressed sequence AW259572, thyroidhormone receptor, alpha (erythroblasticleukemia viral (v-erb-a) oncogenehomolog, avian)36016023AA891872w, xexpressed sequence BB168308,nicotinamide nucleotidetranshydrogenase130619004AI175875aa, bbfatty acid binding protein 5 (psoriasis-associated), fatty acid binding protein 5,epidermal130619005AI175875iifatty acid binding protein 5 (psoriasis-associated), fatty acid binding protein 5,epidermal132719006AI176393aa, bb, llfatty acid binding protein 5 (psoriasis-associated), fatty acid binding protein 5,epidermal258720740NM_145878d, j, k, t,fatty acid binding protein 5 (psoriasis-bb, gg,associated), fatty acid binding protein 5,kk, llepidermal200424248NM_017332e, ggfatty acid synthase, hypothetical proteinFLJ20604267616725X73371e, jj, kkFc fragment of IgG, low affinity Ilb,receptor for (CD32), Fc receptor, IgG,low affinity Ilb, Mus musculus FCRLmRNA, complete cds, expressedsequence AI528646, immunoglobulinsuperfamily receptor translocationassociated 27183250AA997765h, l, llfibrillin 1, fibrillin 1 (Marfan syndrome),fibulin 258521998AA944398ggfibulin 27111530AA799773a, o, q, y,filamin A, alpha (actin binding proteinee, ff,280)hh, jj, kk7111531AA799773a, o, q, z,filamin A, alpha (actin binding proteinff, hh, kk280)165120519C06598aa, bbFK506 binding protein 1A (12 kD), FK506binding protein 1a (12 kDa), FK506binding protein 2 (13 kDa), FK506binding protein 2 (13 kD), FK506 bindingprotein 4 (59 kDa), FK506 bindingprotein 5 (51 kDa)84413093AI012177h, lFK506 binding protein 4 (59 kD), RIKENcDNA 4930571K23 gene117013090AI136977cc, ddFK506 binding protein 4 (59 kD), RIKENcDNA 4930571K23 gene148713092AI231547jj, kkFK506 binding protein 4 (59 kD), RIKENcDNA 4930571K23 gene149523165AI231799y, zFriedreich ataxia region gene X123178913731NM_012755rFYN oncogene related to SRC, FGR,YES, Fyn proto-oncogene82913296AI011020llFYVE zinc finger phosphatase, Musmusculus, clone IMAGE: 3668035,mRNA, partial cds, Mus musculus, cloneMGC: 27983 IMAGE: 3596732, mRNA,complete cds, X-linked myotubularmyopathy gene 1, myotubular myopathy 1124112695AI170948qG protein-coupled receptor190018313NM_013220a, kkGA binding protein transcription factor,beta subunit 1 (53 kD), GA bindingprotein transcription factor, beta subunit2 (47 kD), Homo sapiens cDNAFLJ32449 fis, clone SKMUS2001662,moderately similar to Oryctolaguscuniculus CARP mRNA, RIKEN cDNA1700012M14 gene, RIKEN cDNA4933432B13 gene, ankyrin repeatdomain 2 (stretch responsive muscle),ankyrin repeat domain 5, cardiac ankyrinrepeat protein, cardiac responsiveadriamycin protein208125445NM_021654rgap junction membrane channel proteinalpha 4, gap junction protein, alpha 4,37 kD (connexin 37)9127451AI029450y, zglutamyl-prolyl-tRNA synthetase266916780X62660c, f, gglutathione S-transferase A4, glutathioneS-transferase, alpha 4123211585AI170502rGlycogen synthase 2 (liver), Musmusculus, clone MGC: 29379IMAGE: 5051685, mRNA, complete cds,glycogen synthase 1 (muscle), glycogensynthase 1, muscle, glycogen synthase3, brain206322675NM_019358a, n, o,glycoprotein 38, lung type-I cellkkmembrane-associated glycoprotein11612296AI112979w, xGM2 ganglioside activator protein2539606NM_134352a, y, zGPI-anchored metastasis-associatedprotein homolog, plasminogen activator,urokinase receptor, urokinaseplasminogen activator receptor12116852AA801130h, lGRB2-related adaptor protein, GRB2-related adaptor protein 2, SH3 domainprotein 3, Sh3 domain YSC-like 1,growth factor receptor bound protein 2,growth factor receptor-bound protein 2,monocytic adaptor220418023NM_030846bGRB2-related adaptor protein, GRB2-related adaptor protein 2, SH3 domainprotein 3, Sh3 domain YSC-like 1,growth factor receptor bound protein 2,growth factor receptor-bound protein 2,monocytic adaptor232514184NM_031776kkguanine deaminase232514185NM_031776kkguanine deaminase30715887AA875225eguanine nucleotide binding protein (Gprotein), alpha inhibiting activitypolypeptide 2, guanine nucleotidebinding protein, alpha inhibiting 2,guanine nucleotide binding protein,alpha inhibiting 330715888AA875225e, ggguanine nucleotide binding protein (Gprotein), alpha inhibiting activitypolypeptide 2, guanine nucleotidebinding protein, alpha inhibiting 2,guanine nucleotide binding protein,alpha inhibiting 3222115886NM_031035r, bb, llguanine nucleotide binding protein (Gprotein), alpha inhibiting activitypolypeptide 2, guanine nucleotidebinding protein, alpha inhibiting 2,guanine nucleotide binding protein,alpha inhibiting 3117818943AI137495dH2A histone family, member C, H2Ahistone family, member D, H2A histonefamily, member I, H2A histone family,member L, H2A histone family, memberN, H2A histone family, member O, Homosapiens , clone MGC: 21597IMAGE: 4511035, mRNA, complete cds,Mus musculus, similar to H2A histonefamily, member O, clone MGC: 36202IMAGE: 5055276, mRNA, complete cds,expressed sequence R7537040820065AA892647c, d, rH4 histone family, member D, H4 histonefamily, member H, H4 histone family,member I, H4 histone family, member J,H4 histone family, member K, Musmusculus, H4 histone family, member A,clone MGC: 30488 IMAGE: 4205460,mRNA, complete cds, histone 4 protein214920506NM_022686dH4 histone family, member D, H4 histonefamily, member H, H4 histone family,member I, H4 histone family, member J,H4 histone family, member K, Musmusculus, H4 histone family, member A,clone MGC: 30488 IMAGE: 4205460,mRNA, complete cds, histone 4 protein21496121NM_022686d, rH4 histone family, member D, H4 histonefamily, member H, H4 histone family,member I, H4 histone family, member J,H4 histone family, member K, Musmusculus, H4 histone family, member A,clone MGC: 30488 IMAGE: 4205460,mRNA, complete cds, histone 4 protein12852208AI172472cc, ddHCCA2 protein12709538AI172097l, mheat shock factor 1, heat shocktranscription factor 124938820NM_080399j, k, ee,HIF-1 responsive RTP801, Homoff, jj, kksapiens, Similar to RIKEN cDNA1700037B15 gene, clone MGC: 9960IMAGE: 3877854, mRNA, complete cds263723282U90725hhhigh density lipoprotein binding protein(vigilin)23816712NM_053448cc, ddhistone deacetylase 1, histonedeacetylase 2, histone deacetylase 314718036AI230884rHMBA-inducible253124609NM_133585cc, ddHomo sapiens cDNA FLJ12045 fis, cloneHEMBB1001957, RIKEN cDNA1200011N24 gene, optic atrophy 1(autosomal dominant)132112999AI176276h, l, p, q,Homo sapiens cDNA FLJ12570 fis, cloney, z, ggNT2RM40008958353941AI011598t, kkHomo sapiens cDNA FLJ14042 fis, cloneHEMBA1006038, weakly similar toLAMININ ALPHA-5 CHAIN, expressedsequence AA408762, expressedsequence AI853660, laminin, alpha 5255617530NM_138877n, o, iiHomo sapiens cDNA FLJ14413 fis, cloneHEMBA1004670, RIKEN cDNA1500005G05 gene, cytochrome b5reductase 1 (B5R.1), cytochrome b5reductase b5R.2, diaphorase (NADH)(cytochrome b-5 reductase), diaphorase1 (NADH)255617532NM_138877j, kHomo sapiens cDNA FLJ14413 fis, cloneHEMBA1004670, RIKEN cDNA1500005G05 gene, cytochrome b5reductase 1 (B5R.1), cytochrome b5reductase b5R.2, diaphorase (NADH)(cytochrome b-5 reductase), diaphorase1 (NADH)255625039NM_138877ee, ffHomo sapiens cDNA FLJ14413 fis, cloneHEMBA1004670, RIKEN cDNA1500005G05 gene, cytochrome b5reductase 1 (B5R.1), cytochrome b5reductase b5R.2, diaphorase (NADH)(cytochrome b-5 reductase), diaphorase1 (NADH)7273353AA998053iiHomo sapiens cDNA FLJ14455 fis, cloneHEMBB1001908, highly similar toHuman monocytic leukaemia zinc fingerprotein (MOZ) mRNA, zinc finger protein220240420896NM_053592h, lHomo sapiens cDNA FLJ25344 fis, cloneTST01087, RIKEN cDNA 5031412I06gene22119159AA851953u, vHomo sapiens cDNA FLJ30862 fis, cloneFEBRA2003675216315697NM_022939llHomo sapiens cDNA FLJ31164 fis, cloneKIDNE1000104, weakly similar toSYNTAXIN 7, expressed sequenceAU041521, syntaxin 12, syntaxin 16,syntaxin 730915410AA875268jj, kkHomo sapiens cDNA FLJ31499 fis, cloneNT2NE2005441, weakly similar toSPLICEOSOME ASSOCIATEDPROTEIN 4988722592AI013740n, o, w, xHomo sapiens cDNA FLJ31762 fis, cloneNT2RI2007754, weakly similar toINTESTINAL MEMBRANE A4 PROTEIN,hypothetical protein BC010116,hypothetical protein BC0131092673602X68101ee, ffHomo sapiens cDNA FLJ32122 fis, clonePEBLM1000144, moderately similar toTrg, KIAA1058 protein, erythroiddifferentiation regulator, expressedsequence AA959601, expressedsequence R75174257122595NM_139253cc, ddHomo sapiens cDNA FLJ32237 fis, clonePLACE6004966, Human transposon-likeelement mRNA124021284AI170842hhHomo sapiens cDNA FLJ32449 fis, cloneSKMUS2001662, moderately similar toOryctolagus cuniculus CARP mRNA,ankyrin repeat domain 2 (stretchresponsive muscle), ankyrin repeatdomain 5, cardiac ankyrin repeat protein160016340AI638955hhHomo sapiens cDNA FLJ32493 fis, cloneSKNSH2000051, RNA binding motifprotein 9, fox-1 homolog (C. elegans)24123340AA859519d, h, lHomo sapiens cDNA FLJ32971 fis, cloneTESTI2008847167020456H31144j, kHomo sapiens cDNA: FLJ21251 fis,clone COL01259, Homo sapiens, Similarto activated p21cdc42Hs kinase, cloneMGC: 15139 IMAGE: 4302390, mRNA,complete cds89815247AI014169aa, bbHomo sapiens cDNA: FLJ22783 fis,clone KAIA1993, Homo sapiens mRNAfull length insert cDNA cloneEUROIMAGE 703547, Homo sapiensmRNA; cDNA DKFZp434B102 (fromclone DKFZp434B102), KIAA1376protein49214712AA900860ee, ffHomo sapiens mRNA for FLJ00083protein, partial cds, RIKEN cDNA2610312E17 gene, RIKEN cDNA2810047L02 gene, WD repeat domain 5,WD repeat domain 5B, glutamate richWD repeat protein GRWD, hypotheticalprotein FLJ11848, peroxisomebiogenesis factor 7, recombinationprotein REC1415943615AI237645tHomo sapiens mRNA; cDNADKFZp434M2227 (from cloneDKFZp434M2227), Homo sapiensprostate-specific membrane antigenPSM mRNA, exon 6 alternative splicevariant, partial cds, RIKEN cDNA2610028K12 gene, transferrin receptor,transferrin receptor (p90, CD71),transferrin receptor 2172124844M58040u, vHomo sapiens mRNA; cDNADKFZp434M2227 (from cloneDKFZp434M2227), Homo sapiensprostate-specific membrane antigenPSM mRNA, exon 6 alternative splicevariant, partial cds, RIKEN cDNA2610028K12 gene, transferrin receptor,transferrin receptor (p90, CD71),transferrin receptor 25134917AA924140l, mHomo sapiens mRNA; cDNADKFZp566P2324 (from cloneDKFZp566P2324), Homo sapiens, cloneMGC: 21553 IMAGE: 4155396, mRNA, complete cds, KIAA0193 gene product, hypothetical protein BC002980, hypothetical protein FLJ231425434285AA925708r, y, z, jj,Homo sapiens PNAS-29 mRNA, kkcomplete cds, WD repeat domain 1256918108NM_139105a, n, o, llHomo sapiens PP1579 mRNA, completecds, Mus musculus, clone MGC: 6299IMAGE: 2654341, mRNA, complete cds, expressed sequence AW546468, expressed sequence C80305, ribonuclease/angiogenin inhibitor21699286NM_023027l, mHomo sapiens, clone IMAGE: 4096427, mRNA, partial cds, heterogeneousnuclear ribonucleoprotein D-like12396982AI170793kkHomo sapiens, clone IMAGE: 4245141, mRNA, RIKEN cDNA 1110051A18 gene, deleted in colorectal carcinoma, myopalladin, palladin155614722AI235284ggHomo sapiens, clone IMAGE: 5001663,mRNA, partial cds, antigen identified bymonoclonal antibodies 12E7, F21 andO136763953AA963260s, tHomo sapiens, clone MGC: 11072IMAGE: 3688606, mRNA, complete cds, erythrocyte membrane protein band 4.1(elliptocytosis 1, RH-linked), erythrocyteprotein band 4.1-like 226223347AA860015aa, bbHomo sapiens, clone MGC: 12617IMAGE: 2964706, mRNA, complete cds, cyclin M3, cyclin M4148819271AI231566s, tHomo sapiens, clone MGC: 18164IMAGE: 4155088, mRNA, complete cds25721803NM_139256cHomo sapiens, clone MGC: 19524IMAGE: 4329693, mRNA, complete cds, RIKEN cDNA 1110025H24 gene, mannosidase, alpha, class 2C, member 110568665AI071965ee, ffHomo sapiens, clone MGC: 25063IMAGE: 4480702, mRNA, complete cds26958664Z75029y, z, ee,Homo sapiens, clone MGC: 25063ffIMAGE: 4480702, mRNA, complete cds14868004AI231532rHomo sapiens, clone MGC: 26599IMAGE: 4828542, mRNA, complete cds, zinc finger protein 183 (RING finger, C3HC4 type)159211375AI237594u, vHomo sapiens, clone MGC: 8769IMAGE: 3860953, mRNA, complete cds21622006NM_022936aaHomo sapiens, clone MGC: 9645IMAGE: 3922910, mRNA, complete cds,RIKEN cDNA 2310063B19 gene,epoxide hydrolase 2, cytoplasmic,hypothetical protein FLJ11743,hypothetical protein FLJ2240821622008NM_022936w, x, aa,Homo sapiens, clone MGC: 9645bbIMAGE: 3922910, mRNA, complete cds,RIKEN cDNA 2310063B19 gene,epoxide hydrolase 2, cytoplasmic,hypothetical protein FLJ11743,hypothetical protein FLJ22408214420959NM_022598d, rHomo sapiens, Similar to RIKEN cDNA4930513O09 gene, clone MGC: 33185IMAGE: 5269882, mRNA, complete cds,Mus musculus, Similar to hypotheticalprotein DKFZp761J139, cloneMGC: 11924 IMAGE: 3599595, mRNA,complete cds, RIKEN cDNA4930513O09 gene, cellular nucleic acidbinding protein, zinc finger protein 9 (acellular retroviral nucleic acid bindingprotein)214420960NM_022598c, e, rHomo sapiens, Similar to RIKEN cDNA4930513O09 gene, clone MGC: 33185IMAGE: 5269882, mRNA, complete cds,Mus musculus, Similar to hypotheticalprotein DKFZp761J139, cloneMGC: 11924 IMAGE: 3599595, mRNA,complete cds, RIKEN cDNA4930513O09 gene, cellular nucleic acidbinding protein, zinc finger protein 9 (acellular retroviral nucleic acid bindingprotein)35611966AA891800hh, jj, kkhypothetical protein BC008246,inorganic pyrophosphatase,pyrophosphatase (inorganic)35618128AA891800n, ohypothetical protein BC008246,inorganic pyrophosphatase,pyrophosphatase (inorganic)12321427AA801181cc, ddhypothetical protein DKFZp564I0422,hypothetical protein FLJ2315125816731NM_145096hhhypothetical protein DKFZp667O2416,hypothetical protein FLJ20984, leukocytereceptor cluster (LRC) member 4, zincfinger, DHHC domain containing 7, zincfinger, DHHC domain containing 94874732AA900343cc, ddhypothetical protein DKFZp761C169,hypothetical protein SP19237822903AA892250dhypothetical protein FLJ10514117611238AI137410ee, ffhypothetical protein FLJ1288871621119AA997655bhypothetical protein FLJ1456678322801AI009197ehypothetical protein IMAGE34552004303879AA893237ehypothetical protein MBC320542717731AA893194c, fhypothetical protein MGC109745620980AA799633l, mhypothetical protein MGC130165559942AA942697dhypothetical protein MGC313353523452AA925289gghypothetical protein MGC8974220017917NM_024488b, vhypothetical protein, MGC: 8303, likelyortholog of rat CDK5 activator-bindingprotein C5312911995AA801352n, oimmature colon carcinoma transcript 139511994AA892507hhimmature colon carcinoma transcript 117818427AA819891gginositol 1,4,5-triphosphate receptor, type1, ryanodine receptor 1 (skeletal),ryanodine receptor 1, skeletal muscle17201586M57728cinositol polyphosphate-5-phosphatase,72 kDa179015174NM_012756minsulin-like growth factor 2 receptor6962492AA964866u, vinterferon gamma receptor 2, interferongamma receptor 2 (interferon gammatransducer 1)24309059NM_053783j, k, kkinterferon gamma receptor, interferongamma receptor 1189320754NM_013195binterleukin 2 receptor, beta, interleukin 2receptor, beta chain, interleukin 21receptor12794278AI172304einterleukin 2 receptor, gamma (severecombined immunodeficiency), interleukin2 receptor, gamma chain3255384AA891041j, k, p, q,Jun-B oncogene, jun B proto-oncogeney, z, kk209020161NM_021836j, k, p, q, rJun-B oncogene, jun B proto-oncogene22241731NM_031047jj, kkjunction plakoglobin144624117AI229785cc, ddkeratin 19, keratin complex 1, acidic,gene 1953317363AA925150IIKIAA0438 gene product, Mus musculus,clone IMAGE: 3499845, mRNA, partialcds, goliath protein, hypothetical proteinFLJ20552, hypothetical proteinLOC51255, praja 1, praja1, RING-H2motif containing, rotein carrying theRING-H2 sequence motif, similar toRIKEN cDNA 1300002C13, zinc fingerprotein 36425437164NM_134406jj, kkKIAA0602 protein, hypothetical proteinFLJ2074847122490AA899289dKIAA1049 protein87922493AI013466cc, ddKIAA1049 protein8863445AI013724eKIAA1052 protein, hypothetical proteinFLJ13942358289AA799494eKIAA1075 protein, hypothetical proteinFLJ14950, tumor endothelial marker 6257915761NM_145091cc, dd, jj,KIAA1348 protein, protein phosphatasekk1G (formerly 2C), magnesium-dependent, gamma isoform8575595AI012467u, vKIAA1453 protein, Mus musculus,Similar to ubiquitin specific protease 3,clone MGC: 28886 IMAGE: 4911201,mRNA, complete cds, RIKEN cDNA4930511O11 gene, Vhlh-interactingdeubiquitinating enzyme 1, ubiquitinspecific protease 2, ubiquitin specificprotease 20187238NM_013114aa, bbKIAA1894 protein, pregnancy-associatedplasma protein A, selectin P (granulemembrane protein 140 kD, antigenCD62), selectin, platelet242113622NM_053713aa, bb, llKruppel-like factor 1 (erythroid), Kruppel-like factor 2 (lung), Kruppel-like factor 4(gut)242122411NM_053713d, tKruppel-like factor 1 (erythroid), Kruppel-like factor 2 (lung), Kruppel-like factor 4(gut)242125379NM_053713t, llKruppel-like factor 1 (erythroid), Kruppel-like factor 2 (lung), Kruppel-like factor 4(gut)20219071AA850524kLBP protein 32, hypothetical proteinFLJ13782, mammalian grainyhead,upstream binding protein 1209520204NM_022196ee, ff, kkleukemia inhibitory factor, leukemiainhibitory factor (cholinergicdifferentiation factor)1507409AI232268rlow density lipoprotein receptor-relatedprotein associated protein 1, low densitylipoprotein-related protein-associatedprotein 1 (alpha-2-macroglobulinreceptor-associated protein 1)158921653AI237535a, j, k, p,LPS-induced TNF-alpha factorq, y, z262421654U53184a, e, j, k,LPS-induced TNF-alpha factorq, y, z,kk88012233AI013474y, z, ee,lung alpha/beta hydrolase 2ff10228495AI059971a, tlymphotoxin B receptor, lymphotoxinbeta receptor (TNFR superfamily,member 3)220616292NM_030860cc, ddMADS box transcription enhancer factor2, polypeptide A (myocyte enhancerfactor 2A), MADS box transcriptionenhancer factor 2, polypeptide C(myocyte enhancer factor 2C), MADSbox transcription enhancer factor 2,polypeptide D (myocyte enhancer factor2D), myocyte enhancer factor 2A,myocyte enhancer factor 2B, myocyteenhancer factor 2C, myocyte enhancerfactor 2D245516654NM_053963n, omatrix metalloproteinase 12, matrixmetalloproteinase 12 (macrophageelastase), matrix metalloproteinase 26156114642AI235874h, lMicrofibril-associated glycoprotein-2,expressed sequence AI893631,microfibrillar-associated protein 241417923AA892843bmitochondrial ribosomal protein L2422712829AA858695ggmitochondrial ribosomal protein S33163419152AI639387cc, ddmitochondrial ribosomal protein S68516712AA800015eMitogen activated protein kinase 12(Zipper (leucine) protein kinase), integrinlinked kinase, integrin-linked kinase,mitogen activated protein kinase kinasekinase 11, mitogen activated proteinkinase kinase kinase 12, mitogen-activated protein kinase kinase kinase12, mitogen-activated protein kinasekinase kinase 13251816713NM_133409bMitogen activated protein kinase 12(Zipper (leucine) protein kinase), integrinlinked kinase, integrin-linked kinase,mitogen activated protein kinase kinasekinase 11, mitogen activated proteinkinase kinase kinase 12, mitogen-activated protein kinase kinase kinase12, mitogen-activated protein kinasekinase kinase 1324206684NM_053703kkmitogen activated protein kinase kinase6, mitogen activated protein kinasekinase 7, mitogen-activated proteinkinase kinase 3, mitogen-activatedprotein kinase kinase 4, mitogen-activated protein kinase kinase 6,mitogen-activated protein kinase kinase 733221928AA891302b, l, mmitogen-activated protein kinase kinasekinase kinase 2118212654AI137864cc, ddMORF-related gene 15131617223AI176140rMORF-related gene 15, RIKEN cDNA1700060H10 gene, testis expressedgene 18935521672AA891789f, gMORF-related gene X25885095NM_147140u, vMus musculus 0 day neonate headcDNA, RIKEN full-length enriched library,clone: 4833446O15: solute carrier family35 (UDP-galactose transporter), member2, full insert sequence, Mus musculus,Similar to solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GIcNAc)transporter), member 3, cloneMGC: 36317 IMAGE: 5150304, mRNA,complete cds, solute carrier family 35(GMP-sialic acid transporter), member 125351463NM_134334u, v, ggMus musculus 10 day old male pancreascDNA, RIKEN full-length enriched library,clone: 1810054L16: kidney-derivedaspartic protease-like protein, full insertsequence, cathepsin D, cathepsin D(lysosomal aspartyl protease)3597050AA891824n, oMus musculus 13 days embryo headcDNA, RIKEN full-length enriched library,clone: 3110005M20: serine/arginine-richprotein specific kinase 2, full insertsequence, Mus musculus adult malelung cDNA, RIKEN full-length enrichedlibrary, clone: 1200011B22: signalsequence receptor, delta, full insertsequence, serine/threonine kinase 23209620225NM_022198b, l, mMus musculus adult male testis cDNA,RIKEN full-length enriched library,clone: 4930547K11: chloride channel 4-2,full insert sequence, chloride channel 4,chloride channel 4-2106018198AI072063n, oMus musculus adult male testis cDNA,RIKEN full-length enriched library,clone: 4932434L04: adaptor proteincomplex AP-2, alpha 2 subunit, full insertsequence, adaptor protein complex AP-1, gamma 1 subunit, adaptor proteincomplex AP-1, gamma 2 subunit,adaptor protein complex AP-2, alpha 1subunit, adaptor protein complex AP-2,alpha 2 subunit, adaptor-related proteincomplex 1, gamma 1 subunit, adaptor-related protein complex 2, alpha 2subunit, alpha-c large chain of theprotein complex AP-2 associated withclathrin28422781AA874926hhMus musculus dual specificityphosphatase T-DSP10 mRNA, completecds, RIKEN cDNA 5930436K22 gene,protein phosphatase46522783AA894207rMus musculus dual specificityphosphatase T-DSP10 mRNA, completecds, RIKEN cDNA 5930436K22 gene,protein phosphatase109022786AI101659ggMus musculus dual specificityphosphatase T-DSP10 mRNA, completecds, RIKEN cDNA 5930436K22 gene,protein phosphatase236720235NM_053302cc, ddMus musculus dual specificityphosphatase T-DSP10 mRNA, completecds, RIKEN cDNA 5930436K22 gene,protein phosphatase240621709NM_053596j, k, y, llMus musculus endothelin convertingenzyme-2 mRNA, complete cds,endothelin converting enzyme 1,expressed sequence AW322500, meltransforming oncogene-like 1136919184AI178025p, q, kkMus musculus testis expressedhomeobox mRNA, complete cds, RIKENcDNA 5430405H02 gene, RIKEN cDNA5730599O09 gene, TG interacting factor,TGF(beta)-induced transcription factor 2-like, TGFB-induced factor (TALE familyhomeobox), TGFB-induced factor 2(TALE family homeobox)88816584AI013765w, xMus musculus, Arrestin, beta 2, cloneMGC: 6525 IMAGE: 2651372, mRNA,complete cds, RIKEN cDNA 1200006I17gene, arrestin 3, retinal, arrestin, beta 2,expressed sequence AI326910, retinal S-antigen182016581NM_012911ggMus musculus, Arrestin, beta 2, cloneMGC: 6525 IMAGE: 2651372, mRNA,complete cds, RIKEN cDNA 1200006I17gene, arrestin 3, retinal, arrestin, beta 2,expressed sequence AI326910, retinal S-antigen19655676NM_017188ee, ffMus musculus, clone IMAGE: 3588380,mRNA, partial cds, unc-119 homolog (C.elegans), unc119 homolog (C. elegans)219123488NM_024375n, oMus musculus, clone IMAGE: 4224368,mRNA, partial cds, growth differentiationfactor 1065823927AA957007gMus musculus, glutathione S-transferase, mu type 3 (Yb3), cloneMGC: 30483 IMAGE: 4166881, mRNA,complete cds, RIKEN cDNA0610005A07 gene, glutathione S-transferase M2 (muscle), glutathione S-transferase M5, glutathione S-transferase, mu 5, glutathione S-transferase, mu type 3 (Yb3)226520862NM_031154w, xMus musculus, glutathione S-transferase, mu type 3 (Yb3), cloneMGC: 30483 IMAGE: 4166881, mRNA,complete cds, RIKEN cDNA0610005A07 gene, RIKEN cDNA1110004G14 gene, glutathione S-transferase M2 (muscle), glutathione S-transferase M4, glutathione S-transferase M5, glutathione S-transferase, mu 525331728NM_133618w, xMus musculus, Similar to Acetyl-Co Aacetyltransferase 1, mitochondrial, cloneMGC: 39067 IMAGE: 5365469, mRNA,complete cds, Mus musculus, Similar tohydroxyacyl-Coenzyme Adehydrogenase/3-ketoacyl-Coenzyme Athiolase/enoyl-Coenzyme A hydratase(trifunctional protein), beta subunit, cloneMGC: 7126 IMAGE: 3158015, mRNA,complete cds, acetyl-Coenzyme Aacyltransferase (peroxisomal 3-oxoacyl-Coenzyme A thiolase), hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme Ahydratase (trifunctional protein), betasubunit243225594NM_053799jj, kk, llMus musculus, Similar to aspartyl-tRNAsynthetase, clone MGC: 6719IMAGE: 3586278, mRNA, complete cds,asparaginyl-tRNA synthetase, aspartyl-tRNA synthetase, lysyl-tRNA synthetase7420998AA799803b, l, mMus musculus, Similar to complementcomponent 1, s subcomponent, cloneMGC: 19094 IMAGE: 4196654, mRNA,complete cds, Mus musculus, Similar tocomplement component 1, ssubcomponent, clone MGC: 28492IMAGE: 4166254, mRNA, complete cds,complement component 1, ssubcomponent, protein C250421695NM_130411cMus musculus, Similar to coronin, actinbinding protein, 2A, cloneIMAGE: 4984475, mRNA, partial cds,coronin, actin binding protein 1A,coronin, actin binding protein, 1A75019058AF054618ee, ffMus musculus, Similar to cortactinisoform B, clone MGC: 18474IMAGE: 3981559, mRNA, complete cds,cortactin, ems1 sequence (mammarytumor and squamous cell carcinoma-associated (p80/85 src substrate),hematopoietic cell specific Lyn substrate1, hematopoietic cell-specific Lynsubstrate 124173454NM_053662p, qMus musculus, Similar to cyclin K, cloneMGC: 28173 IMAGE: 3986609, mRNA,complete cds, Paneth cell enhancedexpression, RIKEN cDNA 1810009O10gene, cyclin L, cyclin T1, cyclin T224173455NM_053662p, q, ggMus musculus, Similar to cyclin K, cloneMGC: 28173 IMAGE: 3986609, mRNA,complete cds, Paneth cell enhancedexpression, RIKEN cDNA 1810009O10gene, cyclin L, cyclin T1, cyclin T2237719512NM_053365iiMus musculus, Similar to fatty acidbinding protein 4, adipocyte, cloneMGC: 18548 IMAGE: 3670866, mRNA,complete cds, fatty acid binding protein4, adipocyte21314615NM_022525cc, ddMus musculus, Similar to glutathioneperoxidase 3 (plasma), cloneMGC: 19204 IMAGE: 4237630, mRNA,complete cds, glutathione peroxidase 3,glutathione peroxidase 3 (plasma)2122646AA799301dMus musculus, Similar to ligatin, cloneIMAGE: 4982955, mRNA, partial cds,ligatin18831310NM_013159llMus musculus, Similar to N-argininedibasic convertase 1, clone MGC: 25477IMAGE: 4486176, mRNA, complete cds,insulin degrading enzyme, insulin-degrading enzyme18911714NM_013187a, kkMus musculus, Similar to phospholipaseC, gamma 2 (phosphatidylinositol-specific), clone IMAGE: 3983937, mRNA,partial cds, cell differentiation andembryonic development, expressedsequence AI894140, phospholipase C,gamma 1 (formerly subtype 148)11759166AI37406kkMus musculus, Similar to protein Creceptor, endothelial, clone MGC: 41156IMAGE: 1054063, mRNA, complete cds,protein C receptor, endothelial, protein Creceptor, endothelial (EPCR)239131NM_053537bMus musculus, Similar to solute carrierfamily 22 (organic anion transporter),member 7, clone MGC: 18877IMAGE: 4236556, mRNA, complete cds,expressed sequence AI648912, solutecarrier family 22 (organic aniontransporter), member 6, solute carrierfamily 22 (organic anion transporter),member 775320741AF084186s, tMus musculus, similar to src homologythree (SH3) and cysteine rich domain,clone MGC: 38869 IMAGE: 5361431,mRNA, complete cds, RIKEN cDNA2610027H02 gene, RIKEN cDNA2610301F02 gene, alpha-spectrin 1,erythroid, nesprin-1, spectrin, alpha,erythrocytic 1 (elliptocytosis 2), spectrin,alpha, non-erythrocytic 1 (alpha-fodrin),src homology three (SH3) and cysteinerich domain2099762NM_022245h, lMus musculus, Similar to sulfite oxidase,clone MGC: 28458 IMAGE: 4160277,mRNA, complete cds, RIKEN cDNA0610009N12 gene, cytochrome b-5225114970NM_031127a, h, l, n, oMus musculus, Similar to sulfite oxidase,clone MGC: 28458 IMAGE: 4160277,mRNA, complete cds, RIKEN cDNA1810044O22 gene, RIKEN cDNA2810034J18 gene, sulfite oxidase161718482AI639151ggMus musculus, Similar to thyroidhormone receptor-associated protein,150 kDa subunit, clone MGC: 37192IMAGE: 4954840, mRNA, complete cds,pinin, pinin, desmosome associatedprotein67411500AA963171cc, ddMusashi homolog 1(Drosophila),Musashi homolog 2 (Drosophila), RIKENcDNA 4933434H11 gene, expressedsequence AA959857, heterogeneousnuclear ribonucleoprotein A/B,hypothetical protein DC50, musashihomolog 1 (Drosophila)11610320AA800855b, l, mmyeloid leukemia factor 22537517NM_134350smyxovirus (influenza virus) resistance 1,interferon-inducible protein p78 (mouse),myxovirus (influenza virus) resistance 2244316361NM_053853cc, ddN-acetyltransferase 1 (arylamine N-acetyltransferase)113918509AI04528hhNADH dehydrogenase (ubiquinone) 1beta subcomplex, 6 (17 kD, B17)9121065AA800179s, tneighbor of COX4, neighbor of Cox4201117202NM_017357ggNeural visinin-like protein 1, RIKENcDNA 4921521K07 gene, expressedsequence AI846570, hippocalcin like 4,visinin-like 17723931AI008697n, oneuroligin, neuroligin 1, neuroligin 2,neuroligin 3133222716AI76500f, gNidogen (entactin), nidogen (enactin),nidogen 1156422717AI235948gNidogen (entactin), nidogen (enactin),nidogen 18018378AA799888hhnuclear localization signal deleted invelocardiofacial syndrome, nuclearlocalization signal protein absent in velo-cardio-facial patients77916652AI009019bnuclear receptor subfamily 2, group F,member 6219421NM_024388w, xnuclear receptor subfamily 4, group A,member 1219422NM_024388w, xnuclear receptor subfamily 4, group A,member 123824622NM_053463l, mnucleobindin, nucleobindin 1231920210NM_031710u, vodorant receptor S1 gene, olfactoryreceptor 41, olfactory receptor, family 6,subfamily A, member 1252925369NM_133559l, mPaired basic amino acid cleavingenzyme (furin), paired basic amino acidcleaving enzyme (furin, membraneassociated receptor protein), proproteinconvertase subtilisin/kexin type 3,proprotein convertase subtilisin/kexintype 4205916330NM_019331h, l, llpaired basic amino acid cleavingenzyme (furin, membrane associatedreceptor protein), proprotein convertasesubtilisin/kexin type 3, proproteinconvertase subtilisin/kexin type 4236415867NM_053289a, h, l, w, xpancreatitis-associated protein10068539AI059175epericentriolar material 1247815391NM_057114dperoxiredoxin 121379240NM_022540j, k, w, xperoxiredoxin 3187946NM_013151p, qplasminogen activator, tissue186520878NM_013085bplasminogen activator, urokinase1931923NM_017076a, p, q, y,poliovirus receptor, poliovirus receptor-z, ee, ffrelated 1, poliovirus receptor-related 1(herpesvirus entry mediator C; nectin),poliovirus receptor-related 2 (herpesvirusentry mediator B), poliovirus sensitivity,tumor-associated antigen 1227318654NM_031358a, d, r, y,potassium inwardly rectifying channel,z, ee, ff,subfamily J, member 11, potassiumkkinwardly-rectifying channel, subfamily J,member 11227318655NM_031358d, l, m, jj,potassium inwardly rectifying channel,kksubfamily J, member 11, potassiuminwardly-rectifying channel, subfamily J,member 11170025816L23863n, oPOU domain, class 2, transcription factor3, POU transcription factor18737854NM_013115h, lprostaglandin F receptor, prostaglandinF receptor (FP)23264325NM_031784dprotein inhibitor of activated STAT 1,protein inhibitor of activated STAT 3,protein inhibitor of activated STATgamma, protein inhibitor of activatedSTAT324291016NM_053772r, ggprotein kinase (cAMP-dependent,catalytic) inhibitor alpha, protein kinaseinhibitor, alpha208720035NM_021754a, y, zPRP31 pre-mRNA processing factor 31homolog (yeast), RIKEN cDNA1500019O16 gene, nucleolar protein 5,nucleolar protein 5A (56 kD with KKE/Drepeat), nucleolar protein NOP5/NOP58246018798NM_053978h, l, n, oRAB11a, member RAS oncogene family,RAB28, member RAS oncogene family,expressed sequence AW496496201620778NM_019124llrabaptin 5, rabaptin-5249011632NM_057212bRas-induced senescence 1200815037NM_017347e, rRattus norvegicus extracellular signal-regulated kinase 7 mRNA, complete cds,mitogen activated protein kinase 3,mitogen-activated protein kinase 714076455AI179984aa, bbRattus norvegicus kallistatin mRNA,complete cds, serine (or cysteine)proteinase inhibitor, clade F (alpha-2antiplasmin, pigment epithelium derivedfactor), member 1, serine proteaseinhibitor 223615160AA859346u, vribonuclease P (38 kD)215417808NM_022699cc, ddribosomal protein L3021221867NM_022510c, kkribosomal protein L4189720864NM_013215b, l, mRIKEN cDNA 0610025K21 gene, aldo-keto reductase family 7, member A2(aflatoxin aldehyde reductase)22526525NM_031129ggRIKEN cDNA 0610040H15 gene, RIKENcDNA 2210409E12 gene, transcriptionelongation factor B (SIII), polypeptide 2(18 kD, elongin B)59114763AA944481p, qRIKEN cDNA 1110007F23 gene,angiopoietin 2, angiopoietin-like 3,angiopoietin-like 4, ficolin(collagen/fibrinogen domain containinglectin) 2 (hucolin), ficolin(collagen/fibrinogen domain containing)1, ficolin B5104907AA924091rRIKEN cDNA 1110031I02 gene, generich cluster, B gene, hypothetical proteinFLJ22222, leprecan, leprecan 1239721940NM_053568fRIKEN cDNA 1110033E03 gene,phosphate cytidylyltransferase 2,ethanolamine42024279AA892919dRIKEN cDNA 1300003A17 gene, RIKENcDNA 3222402O04 gene, expressedsequence C76800, hypothetical proteinDKFZp761B2423, myeloid/lymphoid ormixed-lineage leukemia, nucleolar andcoiled-body phosphoprotein 1, nucleolarand coiled-body phosphprotein 1216024283NM_022869s, tRIKEN cDNA 1300003A17 gene, RIKENcDNA 3222402O04 gene, expressedsequence C76800, hypothetical proteinDKFZp761B2423, myeloid/lymphoid ormixed-lineage leukemia, nucleolar andcoiled-body phosphoprotein 1, nucleolarand coiled-body phosphprotein 1245915343NM_053973aaRIKEN cDNA 1300010C19 gene, RIKENcDNA 5730543C08 gene, Ras-relatedGTP-binding protein, expressedsequence AI255374, small GTPase,homolog (S. cerevisiae)24511635AA859645j, k, llRIKEN cDNA 1300011D16 gene,attractin, testis intracellular mediatorprotein21284242NM_022521b, l, mRIKEN cDNA 1300019H02 gene, RIKENcDNA 2900006B13 gene, ornithineaminotransferase, ornithineaminotransferase (gyrate atrophy)76311368AI007948l, mRIKEN cDNA 1500006O09 gene,hypothetical protein FLJ23445134210310AI176961n, oRIKEN cDNA 1500031N16 gene,mitochondrial ribosomal protein L1225558468NM_138861bRIKEN cDNA 1600016E11 gene,mitogen regulated protein, proliferin 3,prolactin, prolactin-like protein M,proliferin, proliferin 21341754AA817837kkRIKEN cDNA 1700024D23 gene, RIKENcDNA 4731413G05 gene, potassiumchannel TREK-2, potassium channel,subfamily K, member 2, potassiumchannel, subfamily K, member 2 (TREK-1), potassium channel, subfamily K,member 5, potassium channel, subfamilyK, member 5 (TASK-2)4021120AA799526p, q, ggRIKEN cDNA 1700043E15 gene, smallnuclear ribonucleoprotein D3 polypeptide(18 kD)125517529AI171460h, lRIKEN cDNA 1810026B04 gene,dicarbonyl/L-xylulose reductase,hydroxysteroid (17-beta) dehydrogenase8, hypothetical protein BC014057,hypothetical protein FLJ14431,oxidoreductase UCPA169924520L20869eRIKEN cDNA 2010002L15 gene,pancreatitis-associated protein,regenerating islet-derived 3 gamma628884AA946362iiRIKEN cDNA 2010006G21 gene, RIKENcDNA 2810425K19 gene, sorting nexin 542319124AA893022iiRIKEN cDNA 2310016C16 gene, RIKENcDNA 3110050F08 gene, glutathioneperoxidase 4, glutathione peroxidase 4(phospholipid hydroperoxidase)43416168AA893280a, y, zRIKEN cDNA 2310076L09 gene,adipose differentiation related protein,adipose differentiation-related protein66512529AA957362dRIKEN cDNA 2410002J21 gene,activator of CREM in testis, expressedsequence AV278559, expressedsequence AW123232, four and a halfLIM domains 2, paxillin, transforminggrowth factor beta 1 induced transcript 1,vascular Rab-GAP/TBC-containing57622317AA943766j, kRIKEN cDNA 2410004D18 gene, RIKENcDNA 4930485D02 gene,aspartylglucosaminidase, expressedsequence AW060726210913480NM_022390lRIKEN cDNA 2610008L04 gene, quinoiddihydropteridine reductase234517556NM_031975j, kRIKEN cDNA 2610009E16 gene,parathymosin, prothymosin alpha25177700NM_133386ee, ffRIKEN cDNA 2610037M15 gene,sphingosine kinase 1, sphingosinekinase 241121972AA892791iiRIKEN cDNA 2610103M17 gene,excision repair cross-complementingrodent repair deficiency,complementation group 1, excisionrepair cross-complementing rodentrepair deficiency, complementationgroup 1 (includes overlapping antisensesequence)2634222AA860024h, l, w, xRIKEN cDNA 2610301D06 gene,eukaryotic translation elongation factor 1gamma87116984AI013161aa, bbRIKEN cDNA 2610301D06 gene,eukaryotic translation elongation factor 1gamma200616382NM_017343cc, ddRIKEN cDNA 2900073G15 gene, myosinregulatory light chain260721583S77900bb, kkRIKEN cDNA 2900073G15 gene, RatmRNA for myosin regulatory light chain(RLC), myosin, light polypeptide,regulatory, non-sarcomeric (20 kD)82718438AI010930e, rRIKEN cDNA 3100001N19 gene,ribosomal protein L14115418439AI111877rRIKEN cDNA 3100001N19 gene,ribosomal protein L14216618107NM_022949f, gRIKEN cDNA 3100001N19 gene,ribosomal protein L1424471352NM_053880aaRIKEN cDNA 3200002I06 gene, dynein,cytoplasmic, intermediate chain 2,dynein, cytoplasmic, intermediatepolypeptide 2, hypothetical proteinMGC2048613814101AA817867iiRIKEN cDNA 4930425N13 gene,hexosaminidase A, hexosaminidase A(alpha polypeptide)127216293AI172183cRIKEN cDNA 4930441F12 gene,reticulon 1, reticulon 2, reticulon 2 (Z-band associated protein)13947213AI179356w, xRIKEN cDNA 4930544G11 gene,expressed sequence AI324259, rashomolog 9 (RhoC), ras homolog A2, rashomolog gene family, member C255323166NM_138839y, z, ee,RIKEN cDNA 4930579A11 gene, likelyff, kkortholog of rat vacuole membraneprotein 1238918826NM_053523bbRIKEN cDNA 5031400M07 gene,homocysteine-inducible, endoplasmicreticulum stress-inducible, ubiquitin-likedomain member 1, hypothetical proteinFLJ2231333621951AA891535cc, ddRIKEN cDNA 5730414C17 gene,hippocampus abundant gene transcript1, hypothetical protein DKFZp564L0864similar to HIAT1, hypothetical proteinFLJ147539387867AI043695tRIKEN cDNA 5730454C12 gene,expressed sequence C79945, glutaminefructose-6-phosphate transaminase 1,glutamine fructose-6-phosphatetransaminase 2, glutamine-fructose-6-phosphate transaminase 2,phosphoribosyl pyrophosphateamidotransferase262220224U47014b, u, vRIKEN cDNA 5730592L21 gene,hypothetical protein FLJ14927,proprotein convertase subtilisin/kexintype 5, thrombospondin, thrombospondintype 1 domain28817303AA874990u, v, w, xRIKEN cDNA 6330407G11 gene,hypothetical protein FLJ10342249717662NM_080697cc, ddRIKEN cDNA 6720463E02 gene, dyneinlight chain 228216082AA874887iiRIKEN cDNA C030018L16 gene, SMC(segregation of mitotic chromosomes 1)-like 1 (yeast), SMC (structuralmaintenace of chromosomes 1)-like 2(S. cerevisiae), SMC (structuralmaintenance of chromosomes 1)-like 1(S. cerevisiae), SMC1 structuralmaintenance of chromosomes 1-like 1(yeast), SMC4 structural maintenance ofchromosomes 4-like 1 (yeast)245416552NM_053961h, l, n, oRIKEN cDNA C030022K24 gene,chromosome 12 open reading frame 8,endoplasmic reticulum protein 29245416553NM_053961h, lRIKEN cDNA C030022K24 gene,chromosome 12 open reading frame 8,endoplasmic reticulum protein 29169223486K02816cc, ddRNA polymerase II transcriptionalcoactivator, activated RNA polymerase IItranscription cofactor 4151813645AI232694hhSEC24 related gene family, member C(S. cerevisiae)7849150AI009198h, lserine/threonine kinase receptorassociated protein, unr-interactingprotein50416976AA901341j, ksialyltransferase, sialyltransferase 7((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosamindealpha-2,6-sialyltransferase) B216518104NM_022948hhsideroflexin 1, sideroflexin 2, sideroflexin 358921522AA944449ggsignal recognition particle 68 kD116323428AI113320llsimilar to arginyl-tRNA synthetase17883600NM_012751asolute carrier family 2 (facilitated glucosetransporter), member 417883601NM_012751tsolute carrier family 2 (facilitated glucosetransporter), member 439817468AA892545tsolute carrier family 22 (organic cationtransporter), member 1-like2399653NM_053580aa, bbsolute carrier family 27 (fatty acidtransporter), member 1, solute carrierfamily 27 (fatty acid transporter),member 4192124695NM_017049csolute carrier family 4 (anion exchanger),member 3, solute carrier family 4, anionexchanger, member 328615116AA874928fsorting nexin 4158511404AI237002hhspermidine synthase, spermine synthase2249882NM_031123dstanniocalcin, stanniocalcin 1239615708NM_053565p, q, y, zSTAT induced STAT inhibitor 3, cytokineinducible SH2-containing protein 3143715078AI228830j, kstearoyl-CoA desaturase (delta-9-desaturase), stearoyl-Coenzyme Adesaturase 2233915077NM_031841iistearoyl-CoA desaturase (delta-9-desaturase), stearoyl-Coenzyme Adesaturase 26044207AA945591n, o, w, xstromal cell derived factor 2, stromal cell-derived factor 2-like 1215020509NM_022689b, r, u, vsynaptosomal-associated protein, 23 kD74415772AB015645cc, ddthyrotropin releasing hormone receptor,thyrotropin releasing hormone receptor2, thyrotropin-releasing hormonereceptor155315004AI235224a, l, n, o,tissue inhibitor of metalloproteinase,x, z, kktissue inhibitor of metalloproteinase 1(erythroid potentiating activity,collagenase inhibitor)243515002NM_053819a, l, k, n,tissue inhibitor of metalloproteinase,o, x, z,tissue inhibitor of metalloproteinase 1hh, kk(erythroid potentiating activity,collagenase inhibitor)243515003NM_053819a, l, k, n,tissue inhibitor of metalloproteinase,o, x, z,tissue inhibitor of metalloproteinase 1hh, kk(erythroid potentiating activity,collagenase inhibitor)3218706AA799471dtitin-cap (telethonin)47717243AA899894rTRAM-like protein, translocating chain-associating membrane protein9816808AI045600w, xTRAM-like protein, translocating chain-associating membrane protein21347505NM_022534iitranscobalamin 2, transcobalamin II;macrocytic anemia225313929NM_031131n, o, hhtransforming growth factor, beta 2188721722NM_013174jj, kktransforming growth factor, beta 3188721723NM_013174p, qtransforming growth factor, beta 312612399AA801307gg, lltransforming, acidic coiled-coilcontaining protein 177112398AI008689s, ttransforming, acidic coiled-coilcontaining protein 14392689AA893515lltranslocation protein 169114342AA964595h, l, s, tTreacher Collins Franceschettisyndrome 1, homolog, Treacher Collins-Franceschetti syndrome 1, expressedsequence AA40884718681521NM_013091a, s, t,tumor necrosis factor receptoree, ff, jj,superfamily, member 12, tumor necrosiskkfactor receptor superfamily, member 12(translocating chain-associationmembrane protein), tumor necrosisfactor receptor superfamily, member 1A,tumor necrosis factor receptorsuperfamily, member 1a, tumor necrosisfactor receptor superfamily, member 22,tumor necrosis factor receptorsuperfamily, member 2313373619AI176588j, ktumor protein p53-binding protein11012125AI102519n, o, w, xTYRO protein tyrosine kinase bindingprotein55116468AA926137hhubiquinol-cytochrome c reductase(6.4 kD) subunit62122708AA946063u, vubiquitin-like 3226718596NM_031325u, vUDP-glucose dehydrogenase226718597NM_031325a, j, k, p,UDP-glucose dehydrogenaseq, y, z,ee, ff25574594NM_138881cvipirin, viral hemorrhagic septicemiavirus(VHSV) induced gene 1227018539NM_031353f, gvoltage-dependent anion channel 1227116777NM_031354hhvoltage-dependent anion channel 2









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The patent application contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).





Claims
  • 1. A method of predicting at least one toxic effect of a compound, comprising: (a) preparing a gene expression profile of a tissue or cell sample exposed to the compound; and (b) comparing the gene expression profile to a database comprising at least part of the data or information of Tables 5A-5LL.
  • 2. A method of claim 1, wherein the gene expression profile prepared from the tissue or cell sample comprises the level of expression for at least one gene.
  • 3. A method of claim 2, wherein the level of expression is compared to a Tox Mean and/or NonTox Mean value in Tables 5A-5LL.
  • 4. A method of claim 3, wherein the level of expression is normalized prior to comparison.
  • 5. A method of claim 1, wherein the database comprises substantially all of the data or information in Tables 5A-5LL.
  • 6. A method of claim 1, wherein the tissue or cell sample is a heart tissue or heart cell sample.
  • 7. A method of predicting at least one toxic effect of a compound, comprising: (a) detecting the level of expression in a tissue or cell sample exposed to the compound of two or more genes from Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II; wherein differential expression of the genes in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II is indicative of at least one toxic effect.
  • 8. A method of predicting the progression of a toxic effect of a compound, comprising: (a) detecting the level of expression in a tissue or cell sample exposed to the compound of two or more genes from Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II; wherein differential expression of the genes in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II is indicative of toxicity progression.
  • 9. A method of predicting the cardiotoxicity of a compound, comprising: (a) detecting the level of expression in a tissue or cell sample exposed to the compound of two or more genes from 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II; wherein differential expression of the genes in 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II is indicative of cardiotoxicity.
  • 10. A method of identifying an agent that modulates the onset or progression of a toxic response, comprising: (a) exposing a cell to the agent and a known toxin; and (b) detecting the expression level of two or more genes from Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II; wherein differential expression of the genes in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II is indicative of toxicity.
  • 11. A method of predicting the cellular pathways that a compound modulates in a cell, comprising: (a) detecting the level of expression in a tissue or cell sample exposed to the compound of two or more genes from Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II; wherein differential expression of the genes in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II is associated the modulation of at least one cellular pathway.
  • 12. The method of any one of claims 7-11, wherein the expression levels of at least 3 genes are detected.
  • 13. The method of any one of claims 7-11, wherein the expression levels of at least 4 genes are detected.
  • 14. The method of any one of claims 7-11, wherein the expression levels of at least 5 genes are detected.
  • 15. The method of any one of claims 7-11, wherein the expression levels of at least 6 genes are detected.
  • 16. The method of any one of claims 7-11, wherein the expression levels of at least 7 genes are detected.
  • 17. The method of any one of claims 7-11, wherein the expression levels of at least 8 genes are detected.
  • 18. The method of any one of claims 7-11, wherein the expression levels of at least 9 genes are detected.
  • 19. The method of any one of claims 7-11, wherein the expression levels of at least 10 genes are detected.
  • 20. A method of claim 7 or 8, wherein the effect is selected from the group consisting of myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, and cardiogenic shock.
  • 21. A method of claim 9, wherein the cardiotoxicity is associated with at least one heart disease pathology selected from the group consisting of myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, and cardiogenic shock.
  • 22. A method of claim 11, wherein the cellular pathway is modulated by a toxin selected from the group consisting of cyclophosphamide, ifosfamide, minoxidil, hydralazine, BI-QT, clenbuterol, isoproterenol, norepinephrine, epinephrine, adriamycin, amphotericin B, epirubicin, phenylpropanolamine, and rosiglitazone.
  • 23. A set of at least two probes, wherein each of the probes comprises a sequence that specifically hybridizes to a gene in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II.
  • 24. A set of probes according to claim 23, wherein the set comprises probes that hybridize to at least 3 genes.
  • 25. A set of probes according to claim 23, wherein the set comprises probes that hybridize to at least 5 genes.
  • 26. A set of probes according to claim 23, wherein the set comprises probes that hybridize to at least 7 genes.
  • 27. A set of probes according to claim 23, wherein the set comprises probes that hybridize to at least 10 genes.
  • 28. A set of probes according to any one of claims 23-27, wherein the probes are attached to a solid support.
  • 29. A set of probes according to claim 28, wherein the solid support is selected from the group consisting of a membrane, a glass support and a silicon support.
  • 30. A solid support comprising at least two probes, wherein each of the probes comprises a sequence that specifically hybridizes to a gene in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II.
  • 31. A solid support of claim 30, wherein the solid support is an array comprising at least 10 different oligonucleotides in discrete locations per square centimeter.
  • 32. A solid support of claim 31, wherein the array comprises at least about 100 different oligonucleotides in discrete locations per square centimeter.
  • 33. A solid support of claim 31, wherein the array comprises at least about 1000 different oligonucleotides in discrete locations per square centimeter.
  • 34. A solid support of claim 31, wherein the array comprises at least about 10,000 different oligonucleotides in discrete locations per square centimeter.
  • 35. A computer system comprising: (a) a database containing information identifying the expression level in a tissue or cell sample exposed to a cardiotoxin of a set of genes comprising at least two genes in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II; and (b) a user interface to view the information.
  • 36. A computer system of claim 35, wherein the database further comprises sequence information for the genes.
  • 37. A computer system of claim 35, wherein the database further comprises information identifying the expression level for the set of genes in the tissue or cell sample before exposure to a cardiotoxin.
  • 38. A computer system of claim 35, wherein the database further comprises information identifying the expression level of the set of genes in a tissue or cell sample exposed to at least a second cardiotoxin.
  • 39. A computer system of any of claims 35-38, further comprising records including descriptive information from an external database, which information correlates said genes to records in the external database.
  • 40. A computer system of claim 39, wherein the external database is GenBank.
  • 41. A method of using a computer system of any one of claims 35-38 to present information identifying the expression level in a tissue or cell of at least one gene in Tables 5A-5LL, comprising: comparing the expression level of at least one gene in Tables 5A-5LL in a tissue or cell exposed to a test agent to the level of expression of the gene in the database.
  • 42. A method of claim 41, wherein the expression levels of at least two genes are compared.
  • 43. A method of claim 41, wherein the expression levels of at least five genes are compared.
  • 44. A method of claim 41, wherein the expression levels of at least ten genes are compared.
  • 45. A method of claim 41, further comprising the step of displaying the level of expression of at least one gene in the tissue or cell sample compared to the expression level when exposed to a toxin.
  • 46. A method of claim 10, wherein the known toxin is a cardiotoxin.
  • 47. A method of claim 43, wherein the cardiotoxin is selected from the group consisting of cyclophosphamide, ifosfamide, minoxidil, hydralazine, BI-QT, clenbuterol, isoproterenol, norepinephrine, epinephrine, adriamycin, amphotericin B, epirubicin, phenylpropanolamine, and rosiglitazone.
  • 48. A method of any one of claims 7-11, wherein nearly all of the genes in Tables 5A-5LL are detected.
  • 49. A method of claim 48, wherein all of the genes in at least one of Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II are detected.
  • 50. A kit comprising at least one solid support of any one of claims 30-34 packaged with gene expression information for said genes.
  • 51. A kit of claim 50, wherein the gene expression information comprises gene expression levels in a tissue or cell sample exposed to a cardiotoxin.
  • 52. A kit of claim 51, wherein the gene expression information is in an electronic format.
  • 53. A method of any one of claims 7-11, wherein the compound exposure is in vivo or in vitro.
  • 54. A method of any one of claims 7-11, wherein the level of expression is detected by an amplification or hybridization assay.
  • 55. A method of claim 54, wherein the amplification assay is quantitative or semi-quantitative PCR.
  • 56. A method of claim 54, wherein the hybridization assay is selected from the group consisting of Northern blot, dot or slot blot, nuclease protection and microarray assays.
  • 57. A method of identifying an agent that modulates at least one activity of a protein encoded by a gene in Tables 5C, 5D, 5E, 5F, 5H, 5J, 5L, 5N, 5P, 5R, 5S, 5U, 5W, 5Y, 5AA, 5CC, 5EE, 5GG, 5HH, and 5II comprising: (a) exposing the protein to the agent; and (b) assaying at least one activity of said protein.
  • 58. A method of claim 57, wherein the agent is exposed to a cell expressing the protein.
  • 59. A method of claim 58, wherein the cell is exposed to a known toxin.
  • 60. A method of claim 59 wherein the toxin modulates the expression of the protein.
  • 61. A method of predicting at least one toxic effect of a compound, comprising: (a) preparing a gene expression profile of a tissue or cell sample exposed to the compound; and (b) comparing the gene expression profile to a database comprising at least part of the data or information of Tables 5A, 5B, 5G, 5I, 5K, 5M, 5O, 5Q, 5T, 5V, 5X, 5Z, 5BB, 5DD, 5FF, 5JJ, 5KK, and 5LL.
  • 62. A method of claim 61, wherein the gene expression profile prepared from the tissue or cell sample comprises the level of expression for at least one gene.
  • 63. A method of claim 62, wherein the level of expression is compared to a Tox Mean and/or Non-Tox Mean value in Tables 5A, 5B, 5G, 5I, 5K, 5M, 5O, 5Q, 5T, 5V, 5X, 5Z, 5BB, 5DD, 5FF, 5JJ, 5KK, and 5LL.
  • 64. A method of claim 63, wherein the level of expression is normalized prior to comparison.
  • 65. A method of claim 61, wherein the database comprises substantially all of the data or information in Tables 5A, 5B, 5G, 5I, 5K, 5M, 5O, 5Q, 5T, 5V, 5X, 5Z, 5BB, 5DD, 5FF, 5JJ, 5KK, and 5LL.
  • 66. A method of claim 61, wherein the tissue or cell sample is a heart tissue or heart cell sample.
RELATED APPLICATIONS

This application is a continuation-in-part of U.S. application Ser. No. 10/191,803, filed Jun. 10, 2002, which claims priority to U.S. Provisional Application No. 60/303,819 filed on Jul. 10, 2001; No. 60/305,623 filed on Jul. 17, 2001; No. 60/369,351 filed on Apr. 3, 2002; and No. 60/377,611 filed on May 6, 2002, all of which are herein incorporated by reference in their entirety. This application is also related to U.S. application Ser. Nos. 09/917,800; 10/060,087; 10/152,319; and 10/______, entitled “Molecular Nephrotoxicology Modeling” (Attorney Docket No. 44921-5089-01-US), filed on Nov. 22, 2002, all of which are also herein incorporated by reference in their entirety.

Provisional Applications (4)
Number Date Country
60303819 Jul 2001 US
60305623 Jul 2001 US
60369351 Apr 2002 US
60377611 May 2002 US
Continuation in Parts (1)
Number Date Country
Parent 10191803 Jul 2002 US
Child 10338044 Jan 2003 US