Patent Application
20160239635
Various embodiments of the present invention generally relate to medication management. More specifically, some embodiments of the present invention relate to systems and methods for monitoring adherence to a medication regimen using a sensor.
Approximately thirty percent of medication prescriptions are never filled. In addition, approximately fifty percent of medications for chronic disease are not taken as prescribed. This lack of adherence has dramatic effects on health. Non-adherence has been estimated to cost the U.S. health care system $200 billion annually. As one example, in ophthalmology, compliance to the medication plan, also referred to as the medication regimen, is vital for preventing visual loss and blindness that may result from chronic conditions such as glaucoma. Almost seventy-five percent of patients admit to some form of noncompliant behavior, over thirty percent do not fill their prescriptions, and nearly fifty percent discontinue their prescriptions within six months.
While forgetfulness is one barrier to medication adherence, it is not the only barrier. In addition, taking the medication at the wrong time, stopping too early, or taking the wrong dose also represent other serious barriers. Unfortunately, there are no effective systems for managing adherence to a medication regimen which can be vital for maintaining or improving health.
Embodiments of the disclosed technology will be described and explained through the use of the accompanying drawings in which:
The drawings have not necessarily been drawn to scale. For example, the dimensions of some of the elements in the figures, such as the elements of the medication device embodiments of
Various embodiments of the disclosed technology generally relate to medication management. More specifically, some embodiments of the present invention relate to systems and methods for monitoring and/or managing adherence to and/or compliance with a medication regimen via use of a sensor, such as a motion sensor of a mobile device. A medication regimen is a plan about medicine to make a person become or stay healthy. A medication regimen, for example: can identify one or more medications that the person is to take or have administered; can identify the frequency and/or time that a dose or doses of a medication are to be taken or administered; can identify the amount or quantity of a dose of the medication to be taken or administered; and/or can identify the duration of time, such as the length of time or the start and end times, that a medication is to be taken or administered.
There are many reasons why a person may not adhere to and/or comply with a medication regimen: forgetting to take the medication; misunderstanding the regimen; making an error about the amount or quantity of a dose of the medicine or the time at which to take the dose; forgetting to refill a prescription; being unable to afford the medication; etc. This lack of adherence may result in a severe impact to the person's health. Further, there may be a number of people who have a vested interest in whether a person is adhering to a medication regimen, such as the person him or herself, a relative of the person, the person's doctor or other medical staff, etc. For example, a child of an elderly parent may want to know when his parent is not adhering to a medication regimen, so that he can take actions to identify the reason(s) for the non-adherence and take action to address those reasons.
The disclosed technology enables a person's adherence and/or compliance to a medication regimen to be monitored and/or managed. Dispensing medicine from a container commonly involves motion of the container, which can be a distinctive motion. For example, when dispensing pills from a bottle, a user may lift the bottle and tilt and shake it so that one or more pills fall through a hole at one end of the bottle. Motion sensor data is data generated by a motion sensor. Motion sensor data generated by a motion sensor that moves in unison with a container can indicate the tilting and shaking that occurs as medicine is being dispensed. The motion sensor data can further indicate vibrations, such as from the medicine shifting in the container while being dispensed. In another example, a user tilts and positions an eye dropper above an eye, and squeezes the eye dropper to dispense a liquid eye medicine into the eye. In yet another example, a user shakes a pressurized inhaler to mix the medicine, positions the inhaler at his mouth, and triggers a mechanism that causes the medicine to be ejected from the inhaler via a release of the pressurized gas. Each of these examples of medicine being dispensed from a container can involve a distinct motion of the container.
Motion sensor data can be analyzed to determine the physical movement or motion of the motion sensor that generates the motion sensor data. For example, a motion sensor can generate data representing an acceleration vector for the motion sensor, which can indicate an acceleration of the motion sensor along that vector. In some embodiments, a motion sensor can move in unison with the container. An analysis of the motion sensor data to determine the associated motion sensor motion can, correspondingly, also determine the associated container motion. The motion can be analyzed to determine if it matches a distinctive motion of a medication being dispensed, and, accordingly, to determine whether the medication was dispensed.
In some embodiments, the motion sensor data and/or the associated indicated motion can be further analyzed to determine the amount or quantity of the medication in the dose of the medicine. For example, an inhaler can exhibit a distinctive motion when a dose of medicine is ejected from the inhaler via a release of pressurized gas. If a user releases multiple doses of medicine from the inhaler, both the inhaler and the motion sensor with which it moves in unison can exhibit the distinctive motion each time one of the doses is released.
In some embodiments, the motion sensor moves in unison with the container by being physically coupled with the container. In one example, the container, which contains medicine, is inserted in and held by a medication device. The medication device is also connected to a mobile device, such as a smart phone. The container, the medication device, and the smart phone are all physically coupled, which causes all three objects to move in unison. The smart phone includes a motion sensor which generates motion sensor data that indicates the motion of the motion sensor. Because the motion sensor is moving in unison with all of the container, the medication device, and the mobile device, the motion sensor data also indicates the motion of these three objects.
In some embodiments, an application running on the smart phone can analyze the motion sensor data to determine the physical movement or motion of a container to which the smart phone is physically coupled. If the motion matches a distinctive motion of a dose of a medication being dispensed, the application can determine that a dose of the medication was dispensed. The application can further analyze the motion sensor data to determine the amount or quantity of the medication that was dispensed in the dose.
In some embodiments, the medication device contains a sensor to sense the medication being dispensed, and the medication device can communicate with the smart phone, such as via Bluetooth or a direct connection using a connector such as Lightning or microUSB. In one example, as the motion sensor moves, it generates motion sensor data that the application analyzes. When the application determines that the motion indicates that a medication may be about to be dispensed, the application sends a signal to the medication device to activate the sensor of the medication device.
The sensor is, in this example, an optical sensor that is used in combination with a laser to determine when medicine is dispensed as indicated by the laser beam fluctuating and/or being interrupted. The laser and the associated sensor are positioned such that any medication leaving the container disrupts the laser beam. As the medication is dispensed, the application detects breaks or other disruptions of the laser beam based on the sensor data. The application further determines, based on the fluctuations in the sensor data, dose information, such as how many pills were dispensed in the current dose.
The current dose can be one of a number of doses of a medication regimen. In some embodiments, the smart phone determines the time and/or date that the dose was dispensed. The smart phone sends the dose information of the current dose, which can include the time/date that the dose was dispensed and/or administered, to a computer system. The smart phone can send the dose information to the computer system, for example, via a wireless network. The computer system can have access to a database that contains the medication regimen for the user. The computer system can compare the dose information to expected dose information as indicated by the medication regimen and determine whether the user is adhering to the medication regimen.
When the computer system determines that the user is not adhering to the medication regimen, the computer system can take an action based on this determination. For example, the computer system can send a message to any or all of a set of people who are listed in the database, such as the user, the user's relative, the doctor or other medical staff, etc. The message can notify the recipients of the non-compliance, and/or can send other compliance-related information.
In the following description, for the purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of embodiments of the present invention. It will be apparent, however, to one skilled in the art that embodiments of the present invention may be practiced without some of these specific details. While, for convenience, embodiments of the present invention are described with reference to monitoring the dispensing of medicine, embodiments of the present invention are equally applicable to monitoring the dispensing of various other types of material or liquid outside of the medical industry.
Further, physical coupling is not limited to the description of the above example. Two objects can be physically coupled in any of a variety of ways. For example, a first object can be physically coupled with a second object by being integrated with or connected to the second object, by being integrated with or connected to a third object that is connected to the second object, etc. When a first object is integrated with or connected to a second object, both objects resultantly move in unison.
Additionally, the motion sensor is not limited to being physically coupled to the container per the above example. In various embodiments, the motion sensor is physically coupled with the container: by being integrated with or connected to the container; by being integrated with or connected to a medication device that is connected to or holding the container; by being integrated with or connected to a mobile device that is connected to the container; by being integrated with or connected to a mobile device that is connected to a medication device that is connected to or holding the container; etc. As these examples illustrate, the motion sensor can be integrated with or connected to the container, the medication device, or the mobile device, as well as other objects, when moving in unison with the container.
Moreover, the techniques introduced here can be embodied as special-purpose hardware (e.g., circuitry), as programmable circuitry appropriately programmed with software and/or firmware, or as a combination of special-purpose and programmable circuitry. For example, in some embodiments, the medication device discussed above includes special purpose hardware for processing and analyzing the sensor data that is discussed above. Hence, embodiments may include a machine-readable medium having stored thereon instructions that may be used to program a computer (or other electronic devices) to perform a process. The machine-readable medium may include, but is not limited to, floppy diskettes, optical disks, compact disc read-only memories (CO-ROMs), magneto-optical disks, ROMs, random access memories (RAMs), erasable programmable read-only memories (EPROMs), electrically erasable programmable read-only memories (EEPROMs), magnetic or optical cards, flash memory, or other types of machine-readable mediums suitable for storing electronic instructions. Additional variations on the above examples will be discussed below.
Brief definitions of terms, abbreviations, and phrases used throughout this application are given below.
The phrases “in some embodiments,” “according to some embodiments,” “in the embodiments shown,” “in other embodiments,” and the like generally mean the particular feature, structure, or characteristic following the phrase is included in at least one implementation of the present invention, and may be included in more than one implementation. In addition, such phrases do not necessarily refer to the same embodiments or different embodiments.
If the specification states a component or feature “may”, “can”, “could”, or “might” be included or have a characteristic, that particular component or feature is not required to be included or have the characteristic.
The term “module” refers broadly to a software, hardware, or firmware (or any combination thereof) component. Modules are typically functional components that can generate useful data or other output using specified input(s). A module may or may not be self-contained. An application program (also called an “application”) may include one or more modules, or a module can include one or more application programs.
The term “cause” and variations thereof refer to either direct causation or indirect causation. For example, a computer system can “cause” an action by sending a message to a second computer system that commands, requests, or prompts the second computer system to perform the action. Any number of intermediary devices may examine and/or relay the message during this process. In this regard, a device can “cause” an action even though it may not be known to the device whether the action will ultimately be executed.
Tactile sensor 130 can be used to provide a touch input interface (e.g., to detect the finger of a user). The user's touch can then activate/deactivate (i.e., turn on-off) the device. In some embodiments, tactile sensor 130 can also detect and record other types of data such as pulse and heart rate. Material/drop detector sensor 140 can detect when matter, such as a pill or a drop of liquid, leaves a container. Material/drop sensor 140 could be an optical (e.g., light emitting diode (LED)/phototransistor) sensor capable of detecting if some matter has been released from the container. In these cases, when the matter is released from the bottle, the drop will block or refract a beam and cause the output of the optical sensor to fluctuate. Material/drop sensor 140 can be placed at the top of the expansion pack and could be activated only when the container is in a specific position, as detected by a motion detector, to conserve power. While a specific jacket configuration and sensor type are discussed here, it is understood that a wide variety of jacket configurations and sensor types can be used to hold various types of containers, and to detect when matter is dispensed or released from the container.
In some embodiments, electronic module compartment 150 houses motion sensor 160, and can house additional modules and/or components (e.g., processors, communication devices, integrated electronics, memory storage devices, batteries, sensors, etc.) of the medication device. For example, in some embodiments, electronic module compartment 150 can include a gesture recognition module. The gesture recognition module can be used for detecting and providing the hand and bottle motion and position. In order to avoid false and unwanted motion measurement, in some embodiments, the gesture recognition module may be activated only when the tactile sensors detect a touch by a user's finger.
In some embodiments, motion sensor 160 generates signals that indicate the physical movement or motion of the motion sensor. Because motion sensor 160 is attached to or embedded in medication device 100 and, resultantly, moves in unison with medication device 100, the generated signals also indicate the motion of medication device 100, and of any container that is held by or otherwise physically connected to medication device 100. In some embodiments, the motion of medication device 100 can be indicated by a motion sensor of a mobile device to which medication device 100 is physically connected, as will be discussed in more detail below. Motion sensor 160, or a motion sensor of a mobile device to which medication device 100 is physically connected, can be used to indicate the position and motion of a container that is physically connected to medication device 100.
As another example, a wireless communication module can be used to send and receive data to and from a computer and portable communication devices. An embedded controller module can include signal preprocessing electronics. Still yet, the module may include Bluetooth, cellular including 3G or 4G, Bluetooth Low Energy (BLE), near field communication (NFC), a wireless local area network (WLAN) transmitter (e.g., a WiFi/IEEE 802.11 compliant transmitter), or other wireless technology to send and load data to a mobile device or computer. Examples of mobile devices include smart phones, tablets, portable media devices, wearable devices, laptops, and other portable computers.
In some embodiments, jacket 105 may have integrated electronics and components embedded throughout. As illustrated in
In the embodiment of
When medicine dispensing system 600 begins to move, such as when a user grabs the container to dispense the medicine, motion sensor 660 can send a signal that causes the electronics of medicine dispensing system 600 to wake up and become active. LED 610 turns on and begins emitting light, which is detected by optical sensor 620. When container 630 is tilted such that a pill is dispensed from the container, as is illustrated in
For example, the optical sensor data can pass through wires 640 and PCB 650 to a processor mounted on the PCB where the processor analyzes the optical sensor data. In another example, the optical sensor data can pass through wires 640 and PCB 650 to a communication device mounted on the PCB, which sends the data wirelessly to a mobile device, where the processor of the mobile device analyzes the optical sensor data. In yet another example, the optical sensor data can pass through wires 640 and PCB 650 to a communication device mounted on the PCB, which sends the data wirelessly to a mobile device, which sends the data via a network to a computer system, where the processor of the computer system can analyze the optical sensor data. In one more example, the optical sensor data can pass through wires 640 and PCB 650 to a communication device mounted on the PCB, which sends the data wirelessly to a Wi-Fi router, which sends the data via a network to a computer system, where the processor of the computer system analyzes the optical sensor data.
A processor that analyzes the optical sensor data can determine, based on the analysis, whether any matter was released from the container, such as a pill. Further, the processor can analyze the data to determine how many pills were released from the container, and can accordingly determine the amount or quantity of the dose of the medicine that was dispensed.
In various embodiments, data from any of a variety of types of sensors can be used by the processor to determine whether any medicine was released from the container, and to determine the amount or quantity of the dose of the medicine that was released. The types of sensors can include a pressure sensor, an optical sensor, a sound sensor, an electrical current sensor, a fluid sensor, a fluid velocity sensor, a force sensor, a chemical sensor, a magnetic field sensor, an electrical field sensor, a drop sensor, a heat sensor, a tactile sensor, etc.
For example, data from a pressure sensor or a sound sensor can be used by a processor to determine whether the medicine of an inhaler was released, and how much medicine was released. The determination can be made based on the detected pressure of the gas inside the inhaler, or the detected sound of pressurized gas being released from the inhaler. As another example, data from a pressure sensor that is located on the bottom of the container, and that receives pressure in proportion to the weight of the container when the container is placed on a surface, can be used by a processor to determine the weight of the medicine that was dispensed from the container. As yet another example, data from a sound sensor can be used by a processor to determine whether a pill was released from a bottle based on the sounds a pill makes when released from a bottle.
In some embodiments, the processor can determine if any matter was released from the container based on data from motion sensor 660. When a user dispenses medication from a container, the container may exhibit a distinctive motion. For example, if the motion of container 630 being moved from one location to another is compared to the motion of container 630 being tilted and shaken to cause a pill to be released from the container, those motions are quite different. The motion of the container being tilted and shaken can be quite distinctive and different from other types of motions. As container 630 is being tilted and shaken to dispense a pill, motion sensor data from motion sensor 660 can be sent to one of the previously discussed processors. The processor can analyze the motion sensor data to determine if it matches a distinctive motion of a medication being dispensed, and, accordingly, to determine whether the medication was dispensed.
In some embodiments, the processor can further analyze the motion sensor data to determine the amount or quantity of the dose of the medicine that was dispensed. For example, when container 630 is a container designed to release a single pill each time the container is tilted and shaken, the processor can analyze the motion sensor data to determine how many times container 630 was tilted and shaken to release a pill. As another example, when container 630 is a container containing eye drops, and one drop is released each time the container is compressed, the processor can analyze the motion sensor data to determine how many times the container was compressed. The technique disclosed in this specification can be applied to a wide variety of distinctive motions associated with dispensing a variety of types of medications, both to determine whether the medication was dispensed and the amount or quantity of the dose of the medication that was dispensed.
In some embodiments, medicine dispensing system 600 is able to send a message that identifies the medicine being dispensed. For example, PCB 650 can include a storage device, such as a read only memory (ROM) or flash memory, that stores an identity of the medication. A communication device or module of medicine dispensing system 600 can send the identity of the medication to another device or module.
While two specific configurations of an attachment component have been described, it is understood that the disclosed technology can be applied to a wide variety of attachment components. As those of ordinary skill will understand, a suitable attachment component can take any of various forms. In some embodiments, the attachment component is a connector. The connector can be, for example, an Apple Lightning connector, an Apple 30-pin connector, an Apple Thunderbolt connector, as a full size USB connector, a standard USB connector, a standard A-type USB connector, a B-type USB connector, a mini USB connector, a mini USB A-type connector, a mini USB B-type connector, a micro-USB connector, a micro-USB A-type connector, a micro-USB B-type connector, a UC-E6 connector, etc. Further, the attachment component can be any physical component that can attach a medication device to a mobile device. In various embodiments, an attachment component can clamp on to smart phone 810, can adhere to smart phone 810, such as utilizing Velcro™ or an adhesive, can attach to smart phone 810, such as with the use of a fastener, etc.
In the embodiments of
A user can attach medication device 820 or 825 to smart phone 810 in preparation for dispensing medicine, such as pill 840, from container 830. In the embodiments of
For example, medication device 820 or 825 can include a tactile sensor that the user triggers when he touches the device in preparation to dispense medicine. Medication device 820 or 825, based on data from the tactile sensor that indicates that the user touched the device, can send a signal to smart phone 810. The medication monitoring application, based on the signal, can begin to analyze motion sensor data from a motion sensor of smart phone 810. Based on motion sensor data that indicates a distinctive motion of medicine being dispensed from a container, smart phone 810 can determine that medication was dispensed from container 830. In some embodiments, data from a sensor of medication device 820 or 825 is analyzed by a processor to determine that medication was dispensed from container 830.
In embodiments where a medication device, such as medication device 820, does not include any electronics, a medication monitoring application can continuously analyze motion sensor data of the motion sensor of smart phone 810 to determine when medicine is dispensed. Using techniques similar to those discussed above, the medication monitoring application can analyze the motion sensor data to determine if it matches a distinctive motion of a medication being dispensed, and, accordingly, to determine whether the medication was dispensed. In some embodiments, using techniques similar to those discussed above, the medication monitoring application can further analyze the motion sensor data to determine the amount or quantity of the dose of the medicine that is dispensed.
However, continuously monitoring sensor data may consume more power than is desirable, or than is needed. To reduce power, the sensor data can be analyzed when data is received that indicates that medicine is about to be dispensed. The medication monitoring application can detect that medicine is about to be dispensed in several ways. For example, the user can use the user interface of smart phone 810 to launch the medication monitoring application, indicating that medicine is about the be dispensed, or to otherwise signal to the medication monitoring application that the medicine is about to be dispensed. Based on being launched or otherwise notified, the medication monitoring application can begin to analyze motion sensor data from the motion sensor of smart phone 810 to determine if medication is being dispensed.
In some embodiments, using techniques similar to those discussed above, the medication monitoring application analyzes data from other sensors of medication device 820 or 825, such as an optical sensor or a pressure sensor, to determine if any medicine was dispensed, and/or the amount or quantity of the dose of the medicine that was dispensed.
Sensor data analysis module 915 monitors motion sensor data from motion sensing module 905. Motion sensing module 905 is a module that includes a motion sensor that can move in unison with a medicine container. For example, medication device 410 of
In some embodiments, sensor data analysis module 915 also monitors sensor data from a second sensor (step 934). As discussed above in the description of
Second sensor module 910 is a module that includes the second sensor. In some embodiments, the motion sensor of motion sensing module 905 can be used to detect if medicine has been released from the container and/or to determine the amount or quantity of the dose of medicine released. The second sensor and second sensor module 910 may be omitted from these embodiments, as the second sensor is not needed to detect if medicine has been released from the container and/or to determine the amount or quantity of the dose of medicine released. In some embodiments, second sensor module 910 sends data from the second sensor to sensor data analysis module 915 (step 928).
After receiving the sensor data of step 934, sensor data analysis module 915 can determine whether to send a wake up signal (step 936). In various embodiments, the wake up signal can be sent to any of motion sensing module 905, second sensor module 910, sensor data analysis module 915, or compliance analysis module 920, any or all of which can be in a low power state. Sensor data analysis module 915 can analyze the motion sensor data to determine if the data indicates that medicine may be about to be dispensed and to determine whether to send a wake up signal (step 936). When sensor data analysis module 915 determines that medicine may be about to be dispensed, the module can send a wake up signal. When sensor data analysis module 915 determines that medicine is not about to be dispensed, the module can continue monitoring sensor data (step 934).
For example, motion sensor data received from motion sensing module 905 can indicate that the motion sensor, and/or a medicine container to which the motion sensor is physically coupled, moved farther than a pre-determined amount, such as three inches. Based on the motion sensor data and/or the associated indication of movement, sensor data analysis module 915 can determine that medicine may be about to be dispensed, and can determine to send a wake up signal. As another example, the second sensor can be a tactile sensor and tactile sensor data received from second sensor module 910 by sensor data analysis module 915 can indicate that a person touched the tactile sensor and/or touched a container that can be used to dispense medicine. Based on the second sensor data, sensor data analysis module 915 can determine that medicine may be about to be dispensed, and can determine to send a wake up signal. As yet another example, motion sensor data received from motion sensing module 905 can indicate that the bottle moved less than a pre-determined amount, such as three inches. Based on the motion sensor data and/or the associated indication of movement, sensor data analysis module 915 can determine that medicine is not about to be dispensed, and can continue monitoring sensor data (step 934).
Steps 924, 930, 937, and 951 are steps that can occur in embodiments where, respectively, motion sending module 905, second sensor module 910, sensor data analysis module 915, and compliance analysis module 920 enter a low power state. At steps 924, 930, 937, and 951, motion sending module 905, second sensor module 910, sensor data analysis module 915, and compliance analysis module 920, respectively, wake up. When a module “wakes up,” the module awakens from a low power reduced functionality/activity state and enters a normal state where the module can perform normal functions/activities. For example, after waking up at steps 924, 930, 937, and 951, motion sending module 905, second sensor module 910, sensor data analysis module 915, and compliance analysis module 920 can, respectively, send motion sensor data (step 926), send second sensor data (step 932), receive reference motion data (step 938) and/or analyze sensor data (step 940), and/or access a database to obtain reference motion data (step 950) and/or to obtain medication regimen data (step 952).
In the example process of
Sensor data analysis module 915 analyzes any of the motion sensor data and/or the second sensor data (step 940) to determine whether medication was dispensed (step 942). In some embodiments, sensor data analysis module 915 analyzes the second sensor data (step 940) to determine whether medication was dispensed (step 942), and/or to determine characteristics of the medication that was dispensed (step 944), such as the amount or quantity of the dispensed dose, the date/time that the dose was dispensed, etc. For example, medicine dispensing system 600 of
In some embodiments, sensor data analysis module 915 analyzes the motion sensor data (step 940) to determine whether medication was dispensed (step 942), and/or to determine the characteristics of the medicine that was dispensed (step 944). For example, medicine dispensing system 600 includes motion sensor 660, and, in some embodiments, the motion sensor data is analyzed to determine whether medicine was dispensed, and/or the amount or quantity of the dose of medicine that was dispensed.
Sensor data analysis module 915 can analyze the motion sensor data in any of various ways, including those discussed above. For example, in some embodiments, sensor data analysis module 915 receives reference motion data from compliance analysis module 920 (step 938), which compliance analysis module 920 can have obtained from a database (step 950). The reference motion data can include data indicating motions characteristic of users who are about to dispense or are dispensing a medication. Sensor data analysis module 915 can compare the reference motion data to the sensor data from motion sensing module 905, and, based on the comparison, can determine whether medication was dispensed (step 942), and/or the amount or quantity of the dose of medication dispensed (step 944).
Pharmaceutical companies run drug studies as part of drug development programs. One of the issues that pharmaceutical companies experience during drug studies is non-adherence of the study participants to the medication regimen of the drug study. To increase the accuracy of the results from these drug studies, many pharmaceutical companies want to increase the accuracy of monitoring study participant adherence to the medication regiment. To further this goal, some pharmaceutical companies would like to obtain evidence above and beyond the sensor data to be able to more accurately verify that a drug study participant adhered to the medication regimen.
In some embodiments, sensor data analysis module 915 sends a message to cause additional evidence that the medication was dispensed to be obtained (step 948). For example, sensor data analysis module 915 can send a message to a medication monitoring application running on a mobile device. The medication monitoring application, based on the message, can: prompt the user to identify the medication; cause the mobile device to, or prompt the user to, take a photo, record a video, or activate an audio recorder; etc. This photo/video/audio data can be manually analyzed by pharmaceutical company employee, or can be automatically analyzed by a computer system, to further validate compliance to the medication regimen.
For example, when a video shows the user applying the medicine, such as when the medicine is an eye drop and the medication device of the embodiment of
As yet another example, when the photo or video shows a medicine label of the medicine container or the medicine itself, the photo/video can be analyzed to determine the identity of the medication being dispensed. As another example, the user can be prompted by the medication monitoring application to speak the name of the medication, and the audio recording can be analyzed to determine the identity of the medication being dispensed. As one more example, the medication monitoring application can display a graphical representation of the medicine(s) that the user is taking to prompt the user to touch the appropriate graphical representation to identify the medication being dispensed.
Sensor data analysis module 915 sends medication data to compliance analysis module 920 (step 946). The medication data can include the determination of whether the medication was dispensed, the date and/or time that the medication was dispensed, the amount or quantity of the medication that was dispensed, evidence that the medication was dispensed, etc. Compliance analysis module 920 is a module that analyzes the medication data to determine a state of compliance of a user to a medication regimen. Compliance analysis module 920 can access a database or other storage medium, such as a file, spreadsheet, etc., to obtain medication regimen data (step 952), which is data regarding a medication regimen.
Compliance analysis module 920 can compare the medication regimen data to the medication data (step 954) to determine a state of compliance to the medication regimen (step 956). In some embodiments, the medication regimen data includes times and dates that doses of a medication are to be taken and the associated amount or quantity of the medication. When compliance analysis module 920 receives medication data for a dose of medicine, it can compare the medication data to the medication regimen data to determine if the dose was taken at the right time, if the correct amount or quantity of medicine was taken, etc. The medication data can include the time and/or date that a medication was dispensed, and the amount or quantity of the dose of the medication. In some embodiments, the medication regimen data and the medication data both include an identity of the medication. Compliance analysis module 920 can compare these two medication identities to determine whether the user is adhering to or complying with the medication regimen.
When compliance analysis module 920 compares the medication regimen data to the medication date, the comparison can include tolerance margins. For example, a dose of a medication can comply with a medication regimen if the time that the medication was dispensed/administered is within a predetermined tolerance margin of the time indicated by the medication regimen for the dose. As another example, a dose of medication can comply if the amount or quantity of the medication dispensed/administered is within a predetermined tolerance margin of the dose as indicated by the medication regimen.
The tolerance margin can further be based on a function that takes into account medication data of other doses. In some embodiments, the tolerance margin for a particular dose of medicine is based on previous doses of the medicine. For example, where previous doses were administered very close to the regimen time, the function may allow the tolerance margin the for the current dose to increase as compared to the tolerance margin for an earlier dose.
Based on the determined state of compliance, the medication data, and/or the medication regimen data, compliance analysis module 920 can take an action (step 958). The action taken can be any of various actions, such as sending a message that indicates the state of compliance, sending a message to cause the user to be notified to take, not take, delay taking, etc., a medication, sending a message to cause a prescription to be renewed and/or refilled, etc. A message that indicates the state of compliance can be sent to any of various parties, such as to the user (via a device such as a mobile device or computer system), to a medical professional associated with the user, to a relative of the user, to a pharmacy, to an insurance company, to a member of a drug study of which the user is a participant, etc.
In some embodiments, the message can notify the various parties that the user is not adhering to the medication regimen, and can provide details as to the type of issue. For example, the message can notify the various parties that the user missed one dose of the medication, or has missed all doses for the past week. As another example, the message can notify the various parties that the user, while taking all the doses, is not taking the doses close enough to the time indicated by the medication regimen.
In the illustrated embodiment, the processing system 1100 includes one or more processors 1110, memory 1111, a communication device 1112, and one or more input/output (I/O) devices 1113, all coupled to each other through an interconnect 1114. The interconnect 1114 may be or include one or more conductive traces, buses, point-to-point connections, controllers, adapters and/or other conventional connection devices. The processor(s) 1110 may be or include, for example, one or more general-purpose programmable microprocessors, microcontrollers, application specific integrated circuits (ASICs), programmable gate arrays, or the like, or any combination of such devices. The processor(s) 1110 control the overall operation of the processing device 1100. Memory 1111 may be or include one or more physical storage devices, which may be in the form of random access memory (RAM), read-only memory (ROM) (which may be erasable and programmable), flash memory, miniature hard disk drive, or other suitable type of storage device, or any combination of such devices. Memory 1111 may store data and instructions that configure the processor(s) 1110 to execute operations in accordance with the techniques described above. The communication device 1112 may be or include, for example, an Ethernet adapter, cable modem, Wi-Fi adapter, cellular transceiver, Bluetooth transceiver, or the like, or any combination thereof. Depending on the specific nature and purpose of the processing device 1100, the I/O devices 1113 can include various devices, e.g., a display (which may be a touch screen display), audio speaker, keyboard, mouse or other pointing device, microphone, camera, sensor, etc.
The disclosed technology can be utilized in various embodiments. For example, in some embodiments, a medication device comprises: a jacket configured to hold a container of medicine; and an attachment component configured to enable the medication device to be physically connected to a mobile device, wherein, when the container is being held by the jacket and the medication device is physically connected to the mobile device, the medicine container, the medication device, and the mobile device move substantially in unison, and wherein, when moved in said unison, the medication device causes a computer system to analyze sensor data obtained by the mobile device to determine that medication was dispensed from the container, the sensor data being data from a sensor.
In some embodiments, the sensor is a motion sensor of the mobile device, and the sensor data is indicative of motion of the medication device when moved in said unison. In some embodiments, the medication device further comprises: a medication detection sensor, wherein the sensor and the medication detection sensor are a same sensor, and the sensor data indicates that the medication was dispensed from the container. In some embodiments, the medication detection sensor is configured to be activated by the mobile device based on motion sensor data that is indicative of motion of the medication device when moved in said unison, the motion sensor data being data from a motion sensor of the mobile device.
In some embodiments, the medication detection sensor is any of a pressure sensor, an optical sensor, a sound sensor, an electrical current sensor, a fluid sensor, a fluid velocity sensor, a force sensor, a chemical sensor, a magnetic field sensor, an electrical field sensor, a drop sensor, a heat sensor, or a tactile sensor. In some embodiments, when moved in said unison, the medication device causes the mobile device to take a photo. In some embodiments, the determination that the medication was dispensed from the container is based on the photo.
In some embodiments, the container is a pill bottle and the medication is a pill, or the container is an eye drop bottle and the medication is an eye drop, or the container is an ointment tube and the medication is an ointment, or the container is a bottle and the medication is a liquid, or the container is a pressurized container and the medication is a gas, liquid, or powder expelled from the container by pressurized gas. In some embodiments, the medication device causes the computer system to determine a state of compliance to a medication regimen based on the determination that the medication was dispensed from the container.
In some embodiments, the medication device causes the computer system to determine the state of compliance based on medication regimen data that is accessed from a storage device and that includes any of time information indicative of a planned time to dispense the medication, or dose information that indicates a quantity of the medication that is associated with a planned dose of the medication. In some embodiments, the sensor indicates a quantity of the medication that was dispensed from the container. In some embodiments, the sensor is a motion sensor of the mobile device. In some embodiments, the mobile device and the computer system are a same device.
In some embodiments, a method for monitoring adherence to a medication regimen using a motion sensor of a mobile device comprises: receiving, by a computer system and from the mobile device, motion sensor data generated by the motion sensor of the mobile device, the motion sensor data being indicative of motion associated with the mobile device when used in conjunction with a medication management device that is physically connected to the mobile device, the mobile device including a medication monitoring application that caused the motion sensor data to be sent to the computer system for analysis; analyzing, by the computer system, the motion sensor data to determine that medication was dispensed and a time that the medication was dispensed, wherein the medication was dispensed from the medication management device or a container held by the medication management device; accessing, by the computer system, a database to obtain medication regimen data associated with the medication regimen that includes time information indicative of a planned time to dispense the medication; determining, by the computer system, a state of compliance to the medication regimen based on a relationship between the time that the medication was dispensed and the planned time; and sending, by the computer system, a compliance message indicative of the state of compliance.
In some embodiments, the medication regimen data includes dose information that indicates a quantity of the medication associated with a planned dose of the medication, and the method further comprises: analyzing, by the computer system, sensor data to determine a quantity of the medication that was dispensed from the container or the medication management device; and comparing the quantity of the medication that was dispensed to the quantity of the medication associated with the planned dose of the medication regimen, wherein the determination of the state of compliance is further based on the comparison of the quantity of the medication that was dispensed to the quantity of the medication associated with the planned dose of the medication regimen.
In some embodiments, the sensor is one of the motion sensor or a medication detection sensor of the medication management device. In some embodiments, the medication regimen data includes dose information that indicates a quantity of the medication that is associated with a planned dose of the medication, and the method further comprises: receiving, from the mobile device, sensor data generated by a medication detection sensor of the medication management device, the sensor data indicating a quantity of the medication that was dispensed from the medication management device or the container; and comparing the quantity of the medication that was dispensed to the quantity of the medication that is associated with the planned dose of the medication regimen, wherein the determination of the state of compliance is further based on the comparison of the quantity of the medication that was dispensed to the quantity of the medication that is associated with the planned dose of the medication regimen.
In some embodiments, the medication regimen data includes dose information indicative of a quantity of the medication associated with a planned dose of the medication, and the method further comprises: receiving, from the mobile device, an indication of a quantity of the medication that was dispensed from the medication management device or the container, the indication of the quantity of the medication that was dispensed being based on data generated by a medication detection sensor of the medication management device; and comparing the quantity of the medication that was dispensed to the quantity of the medication associated with the planned dose of the medication regimen, wherein the determination of the state of compliance is further based on the comparison of the quantity of the medication that was dispensed to the quantity of the medication associated with the planned dose of the medication regimen. In some embodiments, the indication of the quantity of the medication that was dispensed was generated by the medication monitoring application based on the data generated by the medication detection sensor.
In some embodiments, a method comprises: receiving, by a computer system and from a medication management device, motion sensor data generated by a motion sensor of the medication management device, the motion sensor data being indicative of motion of the medication management device; and determining, by the computer system, a state of compliance to a medication regimen based on the motion sensor data. In some embodiments, the motion sensor data was generated when the medication management device was being moved in conjunction with medication indicated by the medication regimen being dispensed.
In some embodiments, the method further comprised: analyzing the motion sensor data to determine that medication was dispensed from the medication management device or a container physically coupled with the medication management device, wherein the container and the medication management device move substantially in unison when physically coupled; and determining a time that the medication was dispensed, wherein the determination of the state of compliance is further based on the determination that the medication was dispensed, and the determination of the time that the medication was dispensed.
In some embodiments, the medication management device is a medicine dispensing system that includes the container, or is a medication device that is configured to move in unison with the container when the container is physically coupled with the medication management device, or is a mobile device. In some embodiments, the method further comprises: accessing a storage device to obtain medication regimen data that includes any of time information indicative of a planned time to dispense the medication, or dose information indicative of a quantity of the medication associated with a planned dose of the medication; and determining any of a time that the medication was dispensed or a quantity of the medication that was dispensed, wherein the determination of the state of compliance to the medication regimen is based on any of a relationship between the time that the medication was dispensed and the planned time, or a relationship between the quantity of the medication that was dispensed and the quantity of the medication associated with the planned dose of the medication regimen.
In some embodiments, the medication management device is a mobile device, and the method further comprises: sending a message to the mobile device to cause the mobile device to prompt a user to take a photo in association with the medication being dispensed. In some embodiments, the medication management device is a mobile device, and the method further comprises: determining that the motion sensor data indicates that medication is being dispensed, and based on the indication that the medication is being dispensed, causing the mobile device to make an audio recording during a time when the motion sensor data indicates that the medication is being dispensed. In some embodiments, the determination of the state of compliance to the medication regimen is based on the audio recording.
In some embodiments, a computer system comprises: a processor; a communication interface coupled to the processor through which to communicate over a network with remote devices; and a storage device coupled to the processor, the storage device storing instructions which when executed by the processor cause the computer system to perform operations including: receiving, via the communication interface and from a medication management device, motion sensor data generated by a motion sensor associated with the medication management device, the motion sensor data being indicative of motion of the medication management device, the motion of the medication management device being in association with medication being dispensed, the medication being associated with a medication regimen; and determining a state of compliance to the medication regimen based on the motion sensor data.
In some embodiments, the operations further include: analyzing the motion sensor data to determine that the medication was dispensed; and determining a time that the medication was dispensed, wherein the determination of the state of compliance is further based on the determination that the medication was dispensed, and the determination of the time that the medication was dispensed.
In some embodiments, the operations further include: accessing the storage device to obtain medication regimen data that includes any of time information indicative of a planned time to dispense the medication, or dose information indicative of a quantity of the medication associated with a planned dose of the medication; and determining any of a time that the medication was dispensed or a quantity of the medication that was dispensed, wherein the determination of the state of compliance to the medication regimen is further based on any of a relationship between the time that the medication was dispensed and the planned time, or a relationship between the quantity of the medication that was dispensed and the quantity of the medication associated with the planned dose of the medication regimen.
In some embodiments. the medication management device is a mobile device, and the operations further include: determining that the motion sensor data indicates that the medication is being dispensed; and based on the indication that the medication is being dispensed, causing the mobile device to, during a time when the motion sensor data indicates that the medication is being dispensed, take a photo, record audio, or record video.
Unless contrary to physical possibility, it is envisioned that (i) the methods/steps described above may be performed in any sequence and/or in any combination, and that (ii) the components of respective embodiments may be combined in any manner.
The techniques introduced above can be implemented by programmable circuitry programmed/configured by software and/or firmware, or entirely by special-purpose circuitry, or by any combination of such forms. Such special-purpose circuitry (if any) can be in the form of, for example, one or more application-specific integrated circuits (ASICs), programmable logic devices (PLDs), field-programmable gate arrays (FPGAs), etc.
Software or firmware to implement the techniques introduced here may be stored on a machine-readable storage medium and may be executed by one or more general-purpose or special-purpose programmable microprocessors. A “machine-readable medium”, as the term is used herein, includes any mechanism that can store information in a form accessible by a machine (a machine may be, for example, a computer, network device, cellular phone, personal digital assistant (PDA), manufacturing tool, any device with one or more processors, etc.). For example, a machine-accessible medium includes recordable/non-recordable media (e.g., read-only memory (ROM); random access memory (RAM); magnetic disk storage media; optical storage media; flash memory devices; etc.), etc.
Note that any and all of the embodiments described above can be combined with each other, except to the extent that it may be stated otherwise above or to the extent that any such embodiments might be mutually exclusive in function and/or structure.
Although the present invention has been described with reference to specific exemplary embodiments, it will be recognized that the invention is not limited to the embodiments described, but can be practiced with modification and alteration within the spirit and scope of the appended claims. Accordingly, the specification and drawings are to be regarded in an illustrative sense rather than a restrictive sense.
