Claims
- 1. The process for preparing a compound having the formula: ##STR3## where R.sub.1 is hydrogen or lower-alkyl; and R.sub.2 is hydrogen, lower-alkyl, lower-alkenyl, lower-alkynyl, phenyl-lower-alkyl or cycloalkyl-lower-alkyl which comprises the steps of heating at a temperature in the range from 125.degree. to 140.degree. C. a compound having the formula: ##STR4## where R.sub.1 and R.sub.2 have the meanings given above with anhydrous orthophosphoric acid under a partial vacuum and hydrolyzing the resulting phosphate esters in an aqueous medium.
- 2. The process according to claim 1 for preparing a compound having the formula: ##STR5## where R.sub.1 is hydrogen or lower-alkyl; and R.sub.2 is lower-alkyl or phenyl-lower-alkyl which comprises the steps of heating a compound having the formula: ##STR6## where R.sub.1 and R.sub.2 have the meanings given above with anhydrous orthophosphoric acid under a partial vacuum and hydrolyzing the resulting phosphate esters in an aqueous medium.
- 3. The process according to claim 2 where the reaction is carried out at a pressure of 9 to 20 mm.
- 4. The process according to claim 2 for preparing N-propylnorapomorphine from N-propylnormorphine.
- 5. The process according to claim 2 for preparing apocodeine from codeine.
- 6. The process according to claim 2 for preparing apomorphine from morphine.
- 7. The process according to claim 2 for preparing N-phenethylnorapomorphine from N-phenethylnormorphine.
RELATED APPLICATIONS
This is a continuation-in-part of our prior, copending application Ser. No. 757,888 filed Jan. 10, 1977, now abandoned.
Non-Patent Literature Citations (1)
Entry |
small et al., J. Org. Chem., 5, pp. 334-349, 1940. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
757888 |
Jan 1977 |
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