Claims
- 1. A compound having the formula (I)
- 2. A compound according to claim 1 wherein
R1 is substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclo; R2 is H, ethyl, propyl, isopropyl, or 2-butyl; and R3 and R4 are OH, with the proviso that when R1 is ethyl, then R2 is not H or methyl.
- 3. A compound according to claim 1 wherein:
R1 is substituted or unsubstituted C1-C5 alkyl; R2 is H, substituted or unsubstituted C1-C5 alkyl, substituted or unsubstituted C2-C5 alkenyl, or substituted or unsubstituted C2-C5 alkynyl; and R3 and R4 are OH, with the proviso that when R1 is ethyl, then R2 is not H or methyl.
- 4. A compound according to claim 1 wherein:
R1 is ethyl; R2 is ethyl, propyl, isopropyl, or 2-butyl; and R3 and R4 are OH.
- 5. A compound according to claim 1 wherein:
R1 is substituted ethyl; R2 is H, substituted or unsubstituted C1-C5 alkyl, substituted or unsubstituted C2-C5 alkenyl, or substituted or unsubstituted C2-C5 alkynyl; and R3 and R4 are OH.
- 6. A compound according to claim 1 wherein:
R1 is substituted ethyl; R2 is H, ethyl, propyl, isopropyl, or 2-butyl; and R3 and R4 are OH.
- 7. A compound according to claim 1 wherein:
R1 is propyl; R2 is H, substituted or unsubstituted C1-C5 alkyl, substituted or unsubstituted C2-C5 alkenyl, or substituted or unsubstituted C2-C5 alkynyl; and R3 and R4 are OH.
- 8. A compound according to claim 1, wherein
R3 and R4 are independently H or OH; R1 is selected from the group consisting of ethyl, 2-fluoroethyl, and 1-propyl; and R2 is selected from the group consisting of methyl, ethyl, isopropyl, and 2-butyl; with the proviso that when R1 is ethyl and R3 is OH, then R2 is not methyl.
- 9. A compound according to claim 1, wherein R1, R2, R3 and R4 are according to the combinations set forth in the table below:
- 10. A compound according to claim 1 selected from the group consisting of:
- 11. A compound according to claim 1, having a structure of the formula:
- 12. A compound according to claim 1, having a structure of the formula:
- 13. A pharmaceutical composition comprising a compound according to claim 1 together with a pharmaceutically acceptable carrier.
- 14. A method for the treatment of a disorder of gastric motility in a patient suffering therefrom, comprising administering to the patient a therapeutically effective dose of a composition of claim 1.
- 15. The use of a compound according to claim 1 for the preparation of a medicament for treating a disorder of gastric disorder in a patient.
- 16. A recombinant host cell engineered to produce 11-deoxyerythromycins, which host cell is capable of expressing a modified version of the DEBS suite of genes (eryAI, eryAII, and eryAII) in which the eryAI gene has been engineered by replacement of the ketoreductase domain in module 2 thereof with a cassette containing a dehydratase domain, an enoylreductase domain, and a ketoreductase domain.
- 17. A recombinant host cell according to claim 16, derived from Saccharopolyspora erythraea K24-1/159-44.
- 18. A method of producing 11-deoxyerythromycins, comprising culturing a recombinant host cell that is capable of expressing a modified version of the DEBS suite of genes (eryAI, eryAII, and eryAII) in which the eryAI gene has been engineered by replacement of the ketoreductase domain in module 2 thereof with a cassette containing a dehydratase domain, an enoylreductase domain, and a ketoreductase domain and optionally recovering the 11-deoxyerythromycins produced.
- 19. A method of claim 18, wherein the host cell is derived from Saccharopolyspora erythraea K24-1/159-44.
- 20. A method according to claim 18, wherein the 11-deoxyerythromycin is 11-deoxyerythromycin B.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. Provisional Application No. 60/407,345, filed Aug. 29, 2002; the disclosure of which is incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60407345 |
Aug 2002 |
US |