The invention relates to a magnetic resonance (MR) method for forming an image of an object from a plurality of signals sampled in a restricted homogeneity region of a main magnet field of the magnetic resonance imaging apparatus, whereas a patient disposed on a table is moved continuously through the bore of the main magnet, such that an image is formed over a region exceeding largely the restricted region of a main magnet field of the magnetic resonance imaging apparatus.
The invention also relates to an MR apparatus and a computer program product for carrying out such a method.
Since it is quite uncomfortable for a patient being disposed in a large bore of the main superconductive magnet of an MR imaging apparatus, there is a trend to use shorter magnets while moving the patient table or couch through the bore of the magnet. Such an apparatus is described e. g. in U.S. Pat. No. 6,385,478. In an MR imaging apparatus excitation pulses are applied to a restricted region of the magnet bore, in which the field is uniform. The data samples collected are Fourier transformed to form a volumetric image of the restricted region. A motor continuously moves a patient couch so that a region of interest passes through the region of good field. The collected data samples are corrected to compensate for the motion so that a volumetric image is formed of greater length than that of the restricted region.
The MR imaging as mentioned above takes quite a long time since it is performed with conventional imaging sequences and even an overlap between successively imaged volumes is preferred in order to discard artefacts produced by errors in the central region. Obviously, the r.f. transmit coil and the r.f. receive coil are disposed in the reference frame of the main magnet, i.e. in its direct vicinity. However, imaging by body coils disposed on different places of a patient was not an issue in this reference. Anyway, it is known that using body coils may cause additional artefacts which cannot be suppressed in an easy manner.
Therefore, it is an object of the present invention to improve the MR imaging method with a relative short main magnet and a moving bed in such a manner, that imaging will be performed in a much shorter time period. Another object of the present invention is to provide an MR apparatus and a computer program product for carrying out the method.
The invention has the main advantage, that shorter main magnets with a restricted homogeneity region can be used whereas data can be sampled in a much shorter time due to undersampling and therefore the scan time is largely reduced in relation to conventional MR imaging with a moving table or bed. Another advantage of the present invention is that the direction of the field-of-view can be oriented in any direction, which means that e.g. flow artefacts can be oriented in an appropriate manner or to orient single slices to some preferred orientation with respect to the tissue structure of the patient.
These and other advantages of the invention are disclosed in the dependent claims and in the following description in which an exemplified embodiment of the invention is described with respect to the accompanying drawings.
The invention may take form in various components and arrangements of components, and in various steps and arrangements of steps. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention.
In
Now the expression “receive situation” is introduced, which means a block of measurements contiguous in time, during which the table 2 has travelled a relatively small distance (e.g. one half or one third or something in between) of the “homogeneity size” of the main magnet 4. During a single receive situation all magnetisation preparations (like presaturation slabs, volume selections etc.) “travel” in principle with the patient 1. Also during a single receive situation, all of the interesting k-space is covered, except for any (potentially significant) undersampling. The full scan over k-space covers K receive situations. In principle, the MR acquisition sequence is identical over all receive situations, except that the “magnetisation preparations” may change place and that there may be some offset in the acquired k-space grid. This is however a refinement of the concept.
During any receive situation, every coil LC1 to LC5 receives information from the patient 1. And so (I+J) sets of information are delivered, where I is the number of local receive coils and J is the number of global receive coils. Some of these sets may be practically zero, e.g. if a receive coil LC1 to LC5 is completely outside the homogeneity volume of main magnet 4. There are K receive situations. Thus, in total, information has been gathered in K*(I+J) “receive instances”.
The clinical doctor wants information from a relatively large volume of interest of the patient 1. Data is acquired while the table or bed 2 is moving relative to the main magnet 4. The displacement Δ thereof relative to the magnet 4 is known at any time. The whole of the MR acquisition is split up in a number of receive situations. During each situation, the excitation and presaturation profiles “travel” with the patient 1. The acquired data are phase-corrected for the offset of table 2 at which they are acquired. During a receive situation, information from the patient 1 is acquired using any MR imaging sequence of any orientation. In practice it may be useful either to orient artefacts (e. g. flow artefacts) in an appropriate direction, or to orient single slices to some preferred orientation M with respect to a specific tissue structure of the patient. However, the information may be seriously undersampled. An example of this method is sketched in
Now, every receive situation has the same subsampling pattern. The only difference between different receive situations is the weighing with respect to the properties of following selected factors:
Concerning items 2 and 3 it is remarked that in theory, with a moving table 2, these patterns varies also within a situation—but if the motion per situation is not exceedingly large, this may be neglected.
In addition, every receive coil (whether local or global) has its own sensitivity pattern. So every receive instance, which is the combination of a receive coil and a receive situation, “sees” a different “overall pattern”, which is a product of the coil-sensitivity pattern and the combined pattern (excitation, saturation, transmit and frequency-response) of the receive situation.
The multitude of folding points 12 is unfolded using all the “overall patterns” of every receive instance. This is done in a manner as in the SENSE method (see e.g. K. Pruessmann et. al. in Proc. ISMRM, 1998, abstracts pp. 579, 799, 803 and 2087)—although, formally, the unfolding matrix may be larger. Nevertheless, the system of equations may be reasonably stable: e.g. for each situation, many folding points 12 may practically “see” a zero pattern, because they fall outside the excitation slab. It is further to be noted that the table motion is flexible: it may be linear, non-linear and even non-monotonic or two-dimensional. The restriction is that it must not travel excessively during one receive situation, e.g. no more as half the homogeneity volume.
In SENSE, a map of coil sensitivity profiles must be available. Such a map can be provided in a reference or coarse calibration measurement with a well-defined phantom. Another possibility is using a low-resolution map of the ratio of signals from an array coil element and from a reference coil of the patient on the table. In the present invention a similar reference measurement is provided. Although data can generally be acquired at any table-motion pattern, including two-dimensional table motion, here a linear one-dimensional movement will be used for data acquisition.
For a better understanding of the involved principles, first a review:
For a given measurement type, the transverse magnetisation is a non-linear effect depending on both the transmit pattern—i.e. on the position in the magnet coordinate system 9, if a global coil is used—and the tissue property—i.e. on the position in the patient coordinate system 3. Since this is very difficult to handle, an approximation is necessary, which can be achieved by using an FFE measurement with very small tip angles (about 5 degrees or less). In that case, the transverse magnetisation can be approximated as f({right arrow over (x)})·α({right arrow over (x)}+{right arrow over (Δ)}), where f({right arrow over (x)}) is the “spin density” function, which is a tissue property for a given measurement (in the proposed case, it mainly depends on proton density). α is the tip angle, which is approximated as being proportional to D({right arrow over (x)})·gtransmit·({right arrow over (x)}+{right arrow over (Δ)}).
For the reconstruction of the proposed method as described in more detail below, ideally one would like to know all information of Si({right arrow over (x)}), gj({right arrow over (x)}+{right arrow over (Δ)}) and D({right arrow over (x)}) (but the last one is not crucial). The value of F({right arrow over (x)}+{right arrow over (Δ)}) is assumed to be known beforehand, and the value of f({right arrow over (x)}) is (at least in principle) not an interesting result of the calibration measurement.
The problem is that not all these parameters are measured. For a given table position {right arrow over (Δ)}, the following is measured:
The patterns of the global coils are assumed to be known (i.e. at least one of them). In practice, that function may be load-dependent, but this can be overcome by the fact that there is a calibrated load-dependency of the sensitivity function, and the load can be easily measured.
A number of discrete reference-scan segments are acquired. During such a segment, the table stands still. Each segment results in a full “image”. The table is then stepped over a number of segments, so for a number of different values of {right arrow over (Δ)}. The knowledge of gj({right arrow over (x)}+{right arrow over (Δ)}) allows calculating the matrix Sl({right arrow over (x)}). Mathematically, each segment would give the result over the full extent of {right arrow over (x)}, but in practice, each segment will provide accurate results only over a sub-range of all {right arrow over (x)}. These partially overlapping ranges can be combined using least-squares fits, resulting in the full map of Si({right arrow over (x)}).
The three-dimensional measurement is oriented in such a way that the frequency-encoding is parallel to the table motion direction—the z-direction. The sampling bandwidth is very high in that direction. The other two directions are phase-encodings, one of which is “fast” compared to table motion. The “slow” phase-encoding direction is called ky. In the patient coordinate system 9 the main magnet 4 is slowly moving with respect to the patient. During the motion of the magnet, profiles are acquired with linearly increasing ky. In
L is the distance that the main magnet 4 covers for a full set of phase-encoding profiles. The table speed is arranged in such a way that L is maximally half of the homogeneity volume—but less (e.g., ¼) is preferable. In
However, this can also be done for any value of {right arrow over (Δ)}ref. That principle allows acquiring:
The receiving and reconstruction of data has been explained above to a great extent. The data is acquired using relatively large steps between profiles, resulting in a (nominally) small “folding volume”, i.e., into lots of folding. For non-cartesian sequences this means that data is sampled relatively sparse. The full extent of k-space is acquired during one scan situation, and the displacement during one scan situation is a fraction (e. g. ⅓) of the homogeneity volume. Every incoming sample is acquired at a very specific value of Δsample. This is taken into account by multiplying every sample of the incoming data with exp (−ikTΔsample). Here, T is the coordination transformation from patient coordinates to scan coordinates, which is relevant for oblique scanning. That operation “displaces” the acquired data to the centre of the patient, even if that is way out of the homogeneity volume. Obviously, one can simplify things by correcting with a fixed Δprofile per profile.
The scan situation has been acquired at an average offset {right arrow over (Δ)}ave. This is relevant to estimate:
The excitation profiles and presaturation profiles are fixed to the patient coordinate system, i.e. travelling with the table 2 as seen from the main magnet 4. So these are known in {right arrow over (x)}. Also the local coil profiles are known in {right arrow over (x)} (see calibration section). All these coil profiles can be multiplied into an overall receive pattern for each coil. In total, if there are K receive situations, then information has been gathered in K∘(I+J) receive instances. Each instance has a different overall receive pattern. This allows for a SENSE-like reconstruction, if there are less than K∘(I+J) folded points over the entire patient 1. In principle, the acquisition stays the same over all receive situations. As a refinement, the phase encoding may be offset by a small amount. This will give some extra phase-encoding, on top of all other mentioned encodings, which will improve the stability of the SENSE-reconstruction.
Geometric Correction
All of above reasoning assumes a perfectly linear gradient system. It assumes that a table-displacement of {right arrow over (Δ)} will cause (a) some different weighting, which has been extensively treated above, and (b) a phase modification of exp(ik.T{right arrow over (Δ)}sample) to a sample. Unfortunately, geometric distortion is another significant complicating factor. An image acquired at offset {right arrow over (Δ)}1 is geometrically distorted when compared to an image acquired at offset {right arrow over (Δ)}2, even if all weightings and the displacement ({right arrow over (Δ)}2−{right arrow over (Δ)}1) have been accounted for.
This problem can be solved since the distortions tend to be small where the excitation and transmit profiles tend to be large. This can be accomplished (a) by making sequences in such a way that there is not too much excitation in geometrically inhomogeneous areas, and (b) by designing the system with low transmit-sensitivity in these areas. The solution is an iterative reconstruction, the explanation thereof is given visually in
In
The invention has been described with reference to the preferred embodiments. Modifications and alterations may occur to others upon reading and understanding the preceding detailed description. It is intended that the invention be constructed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
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03100506 | Feb 2003 | EP | regional |
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PCT/IB2004/050131 | 2/18/2004 | WO | 00 | 8/26/2005 |
Publishing Document | Publishing Date | Country | Kind |
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WO2004/077086 | 9/10/2004 | WO | A |
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