The present invention relates generally to automated laboratory systems for performing scientific processes such as assays and, more particularly, to grippers for lab automation robots of such automated laboratory systems.
Conventional automated laboratory systems include a lab automation robot and a variety of instruments positioned therearound. The lab automation robot may be, for example, a selective compliance articulated robot arm (SCARA) type, and the instruments may include, for example, a liquid handler, an incubator, a reagent dispenser, a sealer, a microplate spectrophotometer, a thermocycler, a thermocycler controller, or any other suitable instrument for performing a desired scientific process such as an assay. In order to perform an assay, a gripper provided at an end effector of the robot may grip a microtiter plate containing samples and transfer the samples between the various instruments. More particularly, the gripper may selectively retrieve a particular microtiter plate from a surface or “nest” associated with one instrument and deposit the microtiter plate on a nest associated with a different instrument, as desired.
Many SCARA type robotic devices, such as that sold by Thermo Fisher Scientific, Inc. under the trademark Spinnaker XT, are configured to position the end effector, and thus the gripper, with four degrees of freedom, consisting of three in translation and one in orientation. For example, such robotic devices may include a stationary base, a swiveling tower rotatably mounted to the stationary base about a first vertical axis, an elevator and accompanying arm vertically translatably mounted to the tower, an articulating forearm pivotably coupled to the arm about a second vertical axis, and a swiveling gripper rotatably mounted to the forearm about a third vertical axis.
Thus, the robotic device may have an aggregate positioning capability of four degrees of freedom, with the position and orientation of the gripper in three-dimensional space being adjustable in all three components of translation and in one component of rotation. More particularly, the gripper may define a Cartesian coordinate system where Z is the normal or yaw axis, X is the longitudinal or roll axis, and Y is the transverse or pitch axis, with translation of the gripper in the Z direction (e.g., moving up and down) achieved by vertical translation of the elevator along the tower, translation of the gripper in the X direction (e.g., moving forward and backward) achieved primarily by articulation of the forearm relative to the arm about the second vertical axis, translation of the gripper in the Y direction (e.g., moving left and right) achieved primarily by articulation of the forearm relative to the arm about the second vertical axis, and rotation of the gripper relative to the Z direction (e.g., yawing) achieved primarily by swiveling the gripper relative to the forearm about the third vertical axis.
However, such robotic devices do not provide rotation of the gripper relative to the X direction (e.g., rolling) or rotation of the gripper relative to the Y direction (e.g., pitching), since the nests from/on which the microtiter plates are to be retrieved/deposited are typically presumed to be horizontally level relative to the gripper and, more particularly, relative to the fingers of the gripper, such that adjustability of the gripper in these two rotatable components is not typically considered desirable or necessary. Despite this presumption, such nests are often at least slightly unlevel relative to the gripper. For example, a nest may be horizontally tilted or pivoted relative to the gripper by as much as 3°. As a result, the gripper may be unable to reliably retrieve a microtiter plate from the relatively unlevel nest or deposit a microtiter plate on the relatively unlevel nest. In some cases, the entire robotic device must be replaced with an entirely different robotic device having an aggregate positioning capability of six degrees of freedom, for example, in order to perform continued operations using the relatively unlevel nest(s).
Thus, it would be desirable to provide an improved gripper for lab automation robots to compensate for nests that are not level relative to the gripper so that the gripper may reliably retrieve/deposit a microtiter plate from/on such nests.
Various additional features and advantages of the invention will become more apparent to those of ordinary skill in the art upon review of the following detailed description of one or more illustrative embodiments taken in conjunction with the accompanying drawings. The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate one or more embodiments of the invention and, together with the general description given above and the detailed description given below, serve to explain the one or more embodiments of the invention.
With reference to
Referring now to
Referring now primarily to
In the embodiment shown, the end effector 36 is operatively coupled to the forearm 20 and rotatable relative thereto about the yaw axis Z via a rotatable hub 70 of the wrist assembly 30. As best shown in
As best shown in
Referring now primarily to
Thus, the gripper body 44 may be rotatable about the yaw axis Z together with the yoke 90, the end effector 36, and the hub 70 relative to the forearm 20, and may also be rotatable about the roll axis Y together with the yoke 90 relative to the end effector 36, the hub 70, and the forearm 20, and may further be rotatable about the pitch axis X relative to the yoke 90, the end effector 36, the hub 70, and the forearm 20. In the embodiment shown, the yaw, roll, and pitch axes Z, Y, X intersect at a center C of the wrist joint 34 located between the end effector 36 and the gripper body 44 and, more particularly, within the square-shaped aperture 94 of the yoke 90. As shown, the pitch axis X is perpendicular to the longitudinal centerline of the gripper body 44 and the roll axis Y is parallel to or coaxial with the longitudinal centerline of the gripper body 44, such that the roll axis Y may be fixedly perpendicular to the pitch axis X irrespective of the orientation of the gripper body 44 about any of the axes Z, Y, X. The illustrated roll axis Y may also be fixedly perpendicular to the yaw axis Z irrespective of the orientation of the gripper body 44 about any of the axes Z, Y, X, while the pitch axis X may only be perpendicular to the yaw axis Z when the gripper body 44 is oriented horizontally about the roll axis Y since rotation of the gripper body 44 about the roll axis Y may change the orientation of the pitch axis X relative to the yaw axis Z.
With continuing reference to
In this regard, each of the illustrated linear actuators 140 of the wrist assembly 30 is electro-mechanical, and includes a sleeve 142 and a shaft 144 selectively extendable from and retractable into the sleeve 142 along a translation axis T of the actuator 140. Each shaft 144 includes a plurality of radially-extending detents 146 for mechanically engaging corresponding indents (not shown) provided in the respective sleeve 142 to inhibit rotation of the shaft 144 about the respective translation axis T relative to the respective sleeve 142. As shown, each of the linear actuators 140 further includes a motor 150 configured to effect linear movement of the shaft 144 relative to the sleeve 142 along the respective translation axis T. In one embodiment, a controller (not shown) may be in operative communication with each of the motors 150 for sending signals thereto instructing the motor 150 to activate or deactivate the respective actuator 140, such as to extend or retract the respective shaft 144 by a desired distance.
In any event, at least a portion of each illustrated sleeve 142 is received by the through-bore 132 of the respective eyelet 130 of the gripper body 44, and at least a portion of each illustrated shaft 144 is received by the through-bore 60 of the respective prong portion 54 of the end effector 36, such that the translation axes T are equally spaced apart from the pitch axis X on a same side thereof and are further equally spaced apart from the roll axis Y on opposite sides thereof. In the embodiment shown, each of the sleeves 142 is fixed against movement relative to the gripper body 44 along the respective translation axis T, and each of the shafts 144 is fixed against movement relative to the end effector 36 along the respective translation axis T. Alternatively, one or both of the actuators 140 may be inverted, with at least a portion of the sleeve 142 received by the through-bore 60 of the respective prong portion 54 of the end effector 36, and at least a portion of the shaft 144 received by the through-bore 132 of the respective eyelet 130 of the gripper body 44. In this manner, linear movement of each shaft 144 relative to the corresponding sleeve 142 along the respective translation axis T may cause movement of the respective eyelet 130 of the gripper body 44 relative to the end effector 36 along the respective translation axis T to thereby cause a corresponding rotation of the gripper body 44 about the pitch axis X and/or roll axis Y.
To that end, each of the illustrated sleeves 142 is angularly rotatably supported within the respective through-bore 132 of the gripper body 44 via respective lower spherical bearing assemblies 160, each including an inner race 162 and an outer race 164 having complementary toroidal outer and inner surfaces, respectively, configured to glide against each other. Each inner race 162 is fixedly coupled to the sleeve 142, and each outer race 164 is fixedly coupled to the gripper body 44. In this regard, each outer race 164 is received within the counterbore 134 of the respective eyelet 130 and captured thereagainst by a respective lower collar 170. As shown, each lower collar 170 includes a respective central through-bore 172 and accompanying counterbore 174 (
Likewise, each of the illustrated shafts 144 is angularly rotatably supported within the respective through-bore 60 of the end effector 36 via respective upper spherical bearing assemblies 180, each including an inner race 182 and an outer race 184 having complementary toroidal outer and inner surfaces, respectively, configured to glide against each other. Each inner race 182 is fixedly coupled to the shaft 144, and each outer race 184 is fixedly coupled to the end effector 36. In this regard, and with reference again to
Thus, the spherical bearing assemblies 160, 180 may cooperate with the respective actuators 140 to permit changes in angular alignment of the translation axes T of the actuators 140 (e.g., relative to the yaw axis Z), such as in response to extension or retraction of at least one of the shafts 144 relative to the respective sleeve(s) 142, in order to accommodate various corresponding movements of the gripper body 44 relative to the end effector 36.
As described above, the actuators 140 arranged within the through-bores 60, 132 are equally spaced apart from the pitch axis X on a same side thereof, and are also equally spaced apart from the roll axis Y on opposite sides thereof. As a result, various operations of one or both of the actuators 140 may be capable of adjusting the orientation(s) of the gripper body 44 (and thus the gripper 32) relative to the pitch and/or roll axes X, Y. More particularly, extension or retraction of at least one of the shafts 144 relative to the respective sleeve(s) 142 may apply a moment of force to the gripper body 44 at the eyelets 130 relative to the pitch and/or rolls axes X, Y for effecting rotation of the gripper body 44 together with the yoke 90 relative to the end effector 36, the hub 70, and the forearm 20 about the roll axis Y, and/or for effecting rotation of the gripper body 44 relative to the yoke 90, the end effector 36, the hub 70, and the forearm 20 about the pitch axis X, for example.
In this regard, and referring now primarily to
Likewise, and referring now primarily to
Thus, the actuators 140 may provide automated adjustment of the gripper 32 about the pitch and roll axes X, Y. As shown in
While not shown, the gripper 32 may include one or more sensors configured to detect a horizontal orientation of a nest and/or of a microtiter plate held thereby relative to the gripper 32, and may be in operative communication with the controller of the actuators 140 for sending signals thereto indicative of the detected relative horizontal orientation. The controller may be configured to determine a desired orientation of the gripper 32 about the pitch and/or roll axes X, Y based on the detected relative horizontal orientation and instruct the motors 150 accordingly so that the gripper 32 and, more particularly, the fingers 46 may be oriented to be horizontally level relative to the nest and/or microtiter plate.
Thus, the robotic device 10 may have an aggregate positioning capability of six degrees of freedom, with the position and orientation of the gripper 32 in three-dimensional space being adjustable in all three components of translation and in all three components of rotation. In one embodiment, the robotic device 10 may initially be equipped with a default “fixed” gripper, such that the robotic device 10 may initially have an aggregate positioning capability of only four degrees of freedom, and may subsequently be readily and easily retrofitted with the wrist assembly 30 including at least the multi-axis gripper 32 to provide the robotic device 10 with the additional two degrees of freedom, without requiring a complete overhaul or replacement of the robotic device 10.
While not shown, the gripper 32 may further include various other components for effecting lateral movement of the fingers 46 toward and away from each other for selectively gripping and releasing a microtiter plate positioned therebetween, such as one or more racks, pinions, and associated actuators, as is known.
While the present invention has been illustrated by the description of various embodiments thereof, and while the embodiments have been described in considerable detail, it is not intended to restrict or in any way limit the scope of the appended claims to such detail. Thus, the various features discussed herein may be used alone or in any combination. Additional advantages and modifications will readily appear to those skilled in the art. The present invention in its broader aspects is therefore not limited to the specific details and illustrative examples shown and described. Accordingly, departures may be made from such details without departing from the scope of the general inventive concept.
The present application claims the filing benefit of U.S. Provisional Application Ser. No. 62/904,732, filed on Sep. 24, 2019, the disclosure of which is incorporated herein by reference in its entirety.
Number | Name | Date | Kind |
---|---|---|---|
4062455 | Flatau | Dec 1977 | A |
4068156 | Johnson et al. | Jan 1978 | A |
4529237 | Gupta | Jul 1985 | A |
4661039 | Brenholt | Apr 1987 | A |
4676541 | Lord | Jun 1987 | A |
4693663 | Brenholt et al. | Sep 1987 | A |
4784422 | Jones et al. | Nov 1988 | A |
4806066 | Rhodes et al. | Feb 1989 | A |
4828453 | Martin et al. | May 1989 | A |
5256128 | Neumann | Oct 1993 | A |
5511147 | Abdel-Malek | Apr 1996 | A |
D496478 | Wu | Sep 2004 | S |
8141924 | Albin | Mar 2012 | B2 |
8176808 | Fisk et al. | May 2012 | B2 |
8206144 | Ng | Jun 2012 | B2 |
8242730 | Nichols et al. | Aug 2012 | B2 |
8322249 | Seavey et al. | Dec 2012 | B2 |
8414043 | Albin et al. | Apr 2013 | B2 |
8442686 | Saito et al. | May 2013 | B2 |
8614559 | Kassow et al. | Dec 2013 | B2 |
9026250 | Summer et al. | May 2015 | B2 |
9149927 | Sturm | Oct 2015 | B2 |
9409292 | Smith et al. | Aug 2016 | B2 |
9555545 | Linnell et al. | Jan 2017 | B2 |
9701018 | Linnell et al. | Jul 2017 | B2 |
9746447 | Fetzer et al. | Aug 2017 | B2 |
9827677 | Gilbertson et al. | Nov 2017 | B1 |
9827678 | Gilbertson et al. | Nov 2017 | B1 |
10112303 | Vakanski et al. | Oct 2018 | B2 |
10272573 | Tan et al. | Apr 2019 | B2 |
20050016313 | Robertson et al. | Jan 2005 | A1 |
20090173177 | Sugawara et al. | Jul 2009 | A1 |
20100101356 | Albin | Apr 2010 | A1 |
20120061155 | Berger et al. | Mar 2012 | A1 |
20120065779 | Yamaguchi | Mar 2012 | A1 |
20130076055 | Hino | Mar 2013 | A1 |
20130341946 | Yamanaka | Dec 2013 | A1 |
20140007731 | Hosek et al. | Jan 2014 | A1 |
20150035303 | Klang | Feb 2015 | A1 |
20150336699 | Fahldieck | Nov 2015 | A1 |
20160252894 | Kram et al. | Sep 2016 | A1 |
20170326737 | Martin et al. | Nov 2017 | A1 |
20180009111 | Ho et al. | Jan 2018 | A1 |
Number | Date | Country |
---|---|---|
2016123083 | Aug 2016 | WO |
Entry |
---|
European Patent Office, Extended European Search Report, Application No. 20197647.9, dated Feb. 23, 2021 (10 pages). |
Number | Date | Country | |
---|---|---|---|
20210086373 A1 | Mar 2021 | US |
Number | Date | Country | |
---|---|---|---|
62904732 | Sep 2019 | US |