Claims
- 1. A gas permeable membrane for effecting extrapulmonary blood gas exchange, the membrane comprising a gas permeable substrate which is coated with a polyfunctional thrombo-resistant composition comprising a siloxane surface which is permeable to a gas onto which a plurality of at least two different bioactive molecules are covalently bonded, the at least two different bioactive molecules being covalently bonded to the siloxane surface and away from the siloxane surface through a plurality of poly(ethylene oxide) chains without precluding the gas permeability of the substrate, said bioactive molecules being capable of counteracting specific blood-material incompatibility reactions.
- 2. A gas permeable membrane for effecting extrapulmonary blood gas exchange as defined in claim 1, wherein the poly(ethylene oxide) chains comprises poly(ethylene oxide) bis (glycidyl ether).
- 3. A gas permeable membrane for effecting extrapulmonary blood gas exchange as defined in claim 1, wherein the poly(ethylene oxide) chains comprises poly(ethylene oxide) bis(isocyanate).
- 4. A gas permeable membrane for effecting extrapulmonary blood gas exchange as defined in claim 1, wherein the plurality of at least two different bioactive molecules is selected from the group consisting of heparin, urokinase, plasmin, and ticiopidine.
- 5. A gas permeable membrane for effecting extrapulmonary blood gas exchange as defined in claim 1, wherein the plurality of at least two different bioactive molecules is selected from the group consisting of heparin, urokinase, TPA, and prostaglandin E.sub.l.
- 6. A gas permeable membrane for effecting extrapulmonary blood gas exchange as defined in claim 1, wherein the plurality of at least two different bioactive molecules is selected form the group consisting of heparin, urokinase, TPA, plasmin, prostaglandin E.sub.1, and ticiopidine.
THE RELATED APPLICATIONS
This application is a file wrapper continuation of U.S. application Ser. No. 07/823,271, filed Jan. 21, 1992, for MULTIFUNCTIONAL THROMBO-RESISTANT COATINGS AND METHODS OF MANUFACTURE which is now abandoned which is a divisional of application Ser. No. 07/215,014, filed Jul. 5, 1988, now U.S. Pat. No. 5,262,451, which is a continuation-in-part of copending application Ser. No. 07/204,115, filed Jun. 8, 1988, now U.S. Pat. No. 4,850,958, in the name of Gaylord Berry, J. D. Mortensen, and Larry D. Rigby and entitled "Apparatus and Method for In Vivo Extrapulmonary Blood Gas Exchange."
US Referenced Citations (61)
Foreign Referenced Citations (1)
Number |
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0054919 |
Dec 1980 |
EPX |
Divisions (1)
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215014 |
Jul 1988 |
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Continuations (1)
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823271 |
Jan 1992 |
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Continuation in Parts (1)
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204115 |
Jun 1988 |
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