Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

Information

  • Research Project
  • 10290033
  • ApplicationId
    10290033
  • Core Project Number
    R01DK130049
  • Full Project Number
    1R01DK130049-01
  • Serial Number
    130049
  • FOA Number
    PA-18-330
  • Sub Project Id
  • Project Start Date
    9/12/2021 - 3 years ago
  • Project End Date
    7/31/2023 - a year ago
  • Program Officer Name
    ARREAZA-RUBIN, GUILLERMO
  • Budget Start Date
    9/12/2021 - 3 years ago
  • Budget End Date
    7/31/2022 - 2 years ago
  • Fiscal Year
    2021
  • Support Year
    01
  • Suffix
  • Award Notice Date
    9/12/2021 - 3 years ago

Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

IIT Project Summary/Abstract The objective of this proposal is to demonstrate a viable, functionally integrated multivariable artificial pancreas that will mitigate meal, physical activity and acute psychological stress challenges without any manual inputs to better regulate glucose levels of people with diabetes. The first generation of artificial pancreas (AP) systems, the hybrid closed-loop AP, collects data from continuous glucose monitoring devices and relies on manual user inputs for mitigating the effects of meals and physical activities. Acute psychological stress and many other physical activities besides planned exercise can affect blood glucose levels and cause challenges to maintaining euglycemia for people with type 1 diabetes. Various physical activities and acute psychological stress events affect the metabolism and sensitivity to insulin in different ways. Hence, their types, intensities and durations, and their individual and concurrent presence must be detected in order to determine the optimal insulin administration. The multivariable artificial pancreas approach provides a well-integrated and user-friendly technology with minimal burden on the user and mitigates the effects of unexpected physical activities and acute psychological stress inducements. Additionally, this technology would be safer by reducing the number and duration of hypoglycemic and hyperglycemic events, compared to APs based exclusively on continuous glucose monitoring device data. Such multivariable AP systems can only be developed by using a sophisticated multivariable approach that uses real-time information from continuous glucose monitoring devices and physiological variables obtained from wearable devices worn in free-living daily life.

IC Name
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • Activity
    R01
  • Administering IC
    DK
  • Application Type
    1
  • Direct Cost Amount
    417780
  • Indirect Cost Amount
    97765
  • Total Cost
    515545
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    847
  • Ed Inst. Type
    BIOMED ENGR/COL ENGR/ENGR STA
  • Funding ICs
    NIDDK:515545\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    HSDO
  • Study Section Name
    Human Studies of Diabetes and Obesity Study Section
  • Organization Name
    ILLINOIS INSTITUTE OF TECHNOLOGY
  • Organization Department
    ENGINEERING (ALL TYPES)
  • Organization DUNS
    042084434
  • Organization City
    CHICAGO
  • Organization State
    IL
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    606163717
  • Organization District
    UNITED STATES