Bachrach, A., et al., “Attachment of Drugs to Polydimethylsiloxanes.” Eur. Polym. J. 20(5):493-500 (1984). |
Barlow, R.B., et al. “A further search for selective antagonists at M2-muscarinic receptors.” Br. J. Pharmac. 89: 837-843 (1986). |
Bonner, T.I., et al. “Identification of a Family of Muscarinic Acetylcholine Receptor Genes.” Science. 237: 527-532 (1987). |
Carrithers, M., et al. “Synthesis and characterization of bivalent peptide ligands targeted to G-protein coupled receptors.” Chem and Biol. 3(7):537-542 (1996). |
Cheronis, J.C., et al. “A new class of bradykinin antagonists: synthesis and in vitro activity of bisuccinmioalkane peptide dimers.” J. Med. Chem. 35: 1563-1572 (1992). |
Eglen, R.M., et al. “Muscarinic Receptor Subtypes: Pharmacology and Therapeutic Potential.” DN&P. 10(8): 462-469 (1997). |
Fisher, A. “Muscarinic agonists for the treatment of Alzheimer's disease: progress and perspectives.” Exp. Opin. Invest. Drugs. 6(10): 1395-1411 (1997). |
Goyal, Raj K. “Muscarinic Receptor Subtypes.” The New England Journal of Medicine. 1022-1029 (1989). |
Graul, et al. “Darifenacin.” Drugs of the Future. 21(11): 1108-1108 (1996). |
Hulme, E.C., et al. “Muscarinic Receptor Subtypes.” Annu. Rev. Pharmacol. Toxicol. 30: 633-673 (1990). |
Ishihara, Y., et al. “Central Cholinergic Agents. III. Synthesis of 2-alkoxy-2,8-diazaspiro[4.5]decane-1,3-diones as Muscarinic Agents.” Chem. Pharm. Bull. 40(5):1177-1185 (1995). |
Jakubik, J., et al., “Positive Cooperativity of Acetylcholine and Other Agonists with Allosteric Ligands on Muscarinic Acetylcholine Receptors”, Mol. Pharm., 52:172-179 (1997). |
Kahne, D. “Combinatorial Approaches to Carbohydrates.” Curr. Opin. Chem. Biol. 1(1): 130-135 (1997). |
Kostenis, E., et al. “Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors.” Eur. J. of Pharmacol. 314: 385-392 (1996). |
Kostenis, E., et al. “Side Chain Variations in Bispyridium-type Allosteric Modulators of M2-Cholinoceptors.” Abstracts. 56(11/12): 1009 (1995). |
Lazareno, S. et al., “Subtype-Selective Positive Cooperative Interactions between Brucine Analogues and Acetylcholine at Muscarinic Receptors: Radioligand Binding Studies”, Mol. Pharm., 53:573-589 (1998). |
LeBoulluec, K.L., et al. “Bivalent indoles exhibiting serotonergic binding affinity.” Bioorg. and Med. Chem. Lett. 5(2): 123-126 (1995). |
Lee, et al. “Alanine Scanning Mutagenesis of Conserved Arginine/Lysine-Argenine/Lysine-X-X-Arginine/Lysine G Protein-Activating Motifs on m1 Muscarinic Acetylcholine Receptors.” Mol. Pharmacology. 50: 140-148 (1996). |
Liang, R., et al. “Parallel Synthesis and Screening of a solid Phase Carbohydrate Library.” Science. 274: 1520-1522 (1996). |
Maggio, R., et al., “Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular “cross-talk” between G-protein-linked receptors”, Proc. Natl. Acad. Sci., USA, 90:3103-3107 (1993). |
Martel, et al. “Revatropate.” Drugs of the Future. 22(2): 135-137 (1997). |
Melchiorre, C., et al. “Antimuscarinic Action of Methoctramine, a New Cardioselective M-2 Muscarinic Receptor Antagonist, Alone and in Combination with Atropine and Gallamine,” Eur. J. Pharmac. 144: 117-124 (1987). |
Mechiorre, C., et al. “The Design of Novel Methoctramine-Related Tetraamines as Muscarinic Receptor Subtype Selective Antagonists.” Life Sci. 56(11/12): 837-844 (1989). |
Melchiorre, C., et al. “Polymethylene tetramines as muscarinic receptor probes.” TIPS. 55-59 (1989). |
Moser, U., et al., “Aliphatic and Heterocyclic Analogues of Arecaidine Propargyl Ester.” Arzneim-Forsch/Drug Res. 45(1): 449-455 (1995). |
Piergentili, A., et al. “Synthesis and Muscarinic Receptors Affinity of a Series of Antagonist Bivalent Ligands.” Il Farmaco 49:2 (1994) 83-87. |
Portoghese, P.S. “The Role of Concepts in Structure-Activity Relationship Studies of Opiod Ligands.” J. Med. Chem. 35(11): 1927-1937 (1992. |
Shuker, S.B., et al. “Discovering High-Affinity Ligands for Proteins: SAR by NMR.” Science. 274: 1531-1534 (1996). |
Sowell, J. W, et al. “Synthesis and Cholinergic Properties of Bis[[(dimethylamino)methyl]furanyl] Analogues of Rantidine.” Am. Chem. Soc.. 35: 1102-1108 (1992). |
Tolterodine. Drugs of the Future. 22(7): 733-737 (1997). |
Watson, N., et al., “Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro”, Br. J. Pharm., 105:107-112 (1992). |
Weiner, B., et al., “Atropine attached to polyethylene Glycols.” Eur. J. Med. Chem. 11(6):525-526 (1976). |
Braude, M.B., et al. “Chemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil.” Chemical Abstracts No. 43492, 84(7) (1976). |
Kostenis, E., et al. “Allosteric effect on muscarinic M2-receptors of derivatives of the alkane-bis-ammonium compound W84. Comparison with bispyridinium-type allosteric modulators.” Eur. J. Med. Chem. 29(12): 947-953 (1994). |
Tomioka, T., “Synthesis of hypotensive ethoxycarbonyloxy benzoates” Database Chemabs Online! Chemical Abstracts Service, Columbus, Ohio. Retrieved from STN Database accession no. 73:120260. |