Claims
- 1. A compound of the formula ##STR51## or a pharmaceutically acceptable salt thereof, wherein X is N or ##STR52## where R.sup.4 is H, halo or C.sub.1 -C.sub.4 alkyl;
- R.sup.1 is H or C.sub.1 -C.sub.4 alkyl;
- R.sup.2 is H or C.sub.1 -C.sub.4 alkyl;
- Y is a direct link, 0 or S;
- m is an integer of from 1 to 4;
- n is 2 or 3; and R.sup.3 is 1- or 2-naphthyl or a group of the formula: ##STR53## where R.sup.5 and R.sup.6 are each independently H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --(CH.sub.2).sub.q OH, halo, trifluoromethyl, cyano, --(CH.sub.2).sub.q NR.sup.7 R.sup.8, --OCO(C.sub.1 -C.sub.4 alkyl), --SO.sub.2 NH.sub.2, --CONR.sup.9 R.sup.10 ;
- where either R.sup.7 and R.sup.8 are each independently H or C.sub.1 -C.sub.4 alkyl, or
- R.sup.7 is H and R.sup.8 is --SO.sub.2 (C.sub.1 -C.sub.4 alkyl), --CONR.sup.9 R.sup.10, --CO(C.sub.1 -C.sub.4 alkyl) or --SO.sub.2 NH.sub.2 ;
- R.sup.9 and R.sup.10 are each independently H or C.sub.1 -C.sub.4 alkyl;
- q is 0, 1 or 2;
- Z and Z.sup.1 are each independently CH.sub.2 or oxygen;
- p is 1, 2 or 3;
- with the proviso that when X is nitrogen, then YR.sub.3 cannot be unsubstituted phenyl.
- 2. A compound as claimed in claim 1 wherein R.sup.1 is H, X is N or CH, m is 1, 2 or 3, n is 2, R.sup.2 is methyl and Y is a direct link or 0.
- 3. A compound as claimed in claim 2 wherein R.sup.3 is 2-naphthyl, or a group of the formula: ##STR54## where R.sup.5 and R.sup.6 are each independently H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, trifluoromethyl, cyano or C.sub.1 -C.sub.4 alkanesulphonamido, and Z.sup.1 is 0 or CH.sub.2.
- 4. A pharmaceutical composition comprising a compound of the formula (I) as claimed in claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.
- 5. A method of treating irritable bowel syndrome in a patient in need of such treatment, characterised by administering to said patient an effective amount of a compound of the formula (I) or pharmaceutically acceptable salt thereof as claimed in claim.
- 6. A method of treating or preventing diseases associated with altered motility and/or tone of smooth muscle comprising administering to a patient a muscarinic receptor antagonist effective amount of a compound according to claim
Priority Claims (1)
Number |
Date |
Country |
Kind |
9000302 |
Jan 1990 |
GBX |
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Parent Case Info
This is a continuation of application Ser. No. 07/877,166, filed as PCT/EP90/02044, Nov. 28, 1990, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4210648 |
Schmidt et al. |
Jul 1980 |
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5002943 |
Mihm et al. |
Mar 1991 |
|
5026699 |
Mihm et al. |
Jun 1991 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
877166 |
Jun 1992 |
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