GenBank Database Accession No. AL008967, Mycobacterium tuberculosis sequence v002, Nov. 18, 1997. |
Czaplinski, K-H. et al., “New benzylpyrimidines: Inhibition of DHFR from various species. QSAR, CoMFA and PC analysis”, Eur.J.Med.Chem. 1995, vol. 30, pp. 779-787. |
Kansy, M. et al., “Synthesis of new 2,4-diamino-5-benzylpyrimidines active against various bacterial species”, Eur.J.Med.Chem. 1992, vol. 27, pp. 237-244. |
Philipp, W.J., “An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobactrium leprae”, Proc. Nat'l. Acad. Sci., Apr. 1996, vol. 93, No. 7, pp. 3132-3137. |
Scuderi, J.D., “Molecular genetic and biochemical analysis of thymidylate synthase and dihydrofolate reductase from mycobacteria,” Dissertation Abstracts International, 1996, vol. 57, No. 8B, pp. 4874B-4875B. |
International Search Report for International Application No. PCT/US97/23557 dated Jun. 15, 1998. |
W. Sirawaraporn et al., “Purification and Characterization of Dihydrofolate Reductase from Wild-Type and Trimethoprim-Resistant Mycobacterium smegmatis”, Experimental Parasitology 72:184-190 (1991). |
GenBank Database Accession No. X59271, “Mycobacterium tuberculosis folA gene (putative) for dihydrofolate reductase”, Jun. 9, 1991. |
Scuderi, Joseph D., Dissertation entitled “Molecular Genetic and Biochemical Analysis of Thymidylate Synthase and Dihydrofolate Reductase from Mycobacteria”, 1996. |
Zywno-van Ginkel et al, “Identification and cloning of the Mycobacterium avium folA gene, required for dihydrofolate reductase activity”, FEMS Microbiology Letters, vol. 156, pp. 69-78, Sep. 1, 1997. |