Claims
- 1. A chemical intermediate of the formula: ##STR123## an N-oxide form, a salt, or a stereochemically isomeric form thereof, wherein:
- A represents a group of the formula:
- --CH.sub.2 --CH.sub.2 -- (a-1),
- --CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-2), or
- --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -- (a-3),
- wherein one or two hydrogen atoms in said groups (a-1) to (a-3) may be replaced by a C.sub.1-6 alkyl group;
- R.sup.1 represents hydrogen, halo, C.sub.1-6 alkylsulfonyl, or aminosulfonyl;
- R.sup.2 represents hydrogen, amino, mono- or di(C.sub.1-6 alkyl)amino, arylC.sub.1-6 alkylamino, or C.sub.1-6 alkylcarbonylamino; and
- R.sup.3 and R.sup.4 each independently represent hydrogen or C.sub.1-6 alkyl.
- 2. The chemical intermediate of claim 1 wherein said chemical intermediate is selected from the group consisting of:
- cis-4-amino-5-chloro-2,3-dihydro-N-(3-methoxy-4-piperidinyl)-7-benzofurancarboxamide;
- cis-4-amino-5-chloro-2,3-dihydro-N-(3-hydroxy-4-piperidinyl)-7-benzofurancarboxamide;
- cis-4-amino-5-chloro-2,3-dihydro-N-(3-methoxy-4-piperidinyl)-2,2-dimethyl-7-benzofurancarboxamide;
- cis-4-amino-5-chloro-2,3-dihydro-N-(3-methoxy-4-piperidinyl)-2-methyl-7-benzofurancarboxamide;
- cis-5-amino-6-chloro-3,4-dihydro-N-(3-methoxy-4-piperidinyl)-2H-1-benzopyran-8-carboxamide;
- salts thereof, and stereoisomers thereof.
CROSS-REFERENCE TO RELATED APPLICATION
This is a division of application Ser. No. 08/301,825, filed Sep. 7, 1994, which was a division of application Ser. No. 07/489,419, filed Mar. 6, 1990, now U.S. Pat. No. 5,374,637, which was a continuation-in-part of application Ser. No. 07/326,941, filed Mar. 22, 1989, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
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9412494 |
Jun 1994 |
WOX |
Divisions (2)
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301825 |
Sep 1994 |
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489419 |
Mar 1990 |
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Continuation in Parts (1)
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326941 |
Mar 1989 |
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