Claims
- 1. A method of protecting a cancer patient being treated for antitumor purposes with a therapeutically acceptable and effective amount of a cardio-toxic anthracycline drug against usually-ensuing cardiac damage without affecting tumor response or delivery of the drug to cardiac tissue sites, comprising orally administering a range of from 750 mg to 2 grams per kg of N-acetyl-cysteine to a patient undergoing therapy with a cardio-toxic anthracycline drug.
- 2. The method of claim 1 wherein the anthracycline drug is adriamycin.
- 3. The method of claim 1 wherein the anthracycline drug is daunomycin.
- 4. The method of claim 1 wherein the dosage of N-acetyl-cysteine administered is 2 grams of N-acetyl-cysteine per kilogram of body weight.
- 5. The method of claim 1 wherein the dosage of N-acetyl-cysteine administered is 5 grams of N-acetyl-cysteine per square meter of the surface area of the human body.
- 6. The method of claim 1 wherein the N-acetyl-cysteine is administered about 1 hour prior to the administration of the anthracycline.
- 7. The method of claim 1 wherein the anthracycline is adriamycin, the dosage of N-acetyl-cysteine administered is 5 grams of N-acetyl-cysteine per square meter of the surface area of the human body, and the N-acetyl-cysteine is administered about 1 hour prior to the administration of the adriamycin.
- 8. The method of claim 1 wherein the anthracycline drug is rubidazone.
- 9. The method of claim 1 wherein the anthracycline drug is carminomycin.
- 10. The method of claim 1 wherein the anthracycline drug is 7-con-O-methylnogarol.
Parent Case Info
This is a continuation-in-part of application Ser. No. 100,496 filed Dec. 5, 1979, now abandoned, which is a continuation of application Ser. No. 24,246 filed Mar. 27, 1979, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4267163 |
DeFelice |
May 1981 |
|
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, 79: 142981a, (1973). |
Chemical Abstracts, 92: 52213r, (1980). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
24246 |
Mar 1979 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
100496 |
Dec 1979 |
|