Claims
- 1. A compound of the formula ##STR12## wherein m is 0 or an integer of 1 to 5;
- q is 2 or 3;
- R is hydrogen or lower alkyl of 1 to 6 carbon atoms in the chain;
- R.sub.1 is lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 1 to 6 carbon atoms, lower cycloalkyl of 3 to 7 ring carbon atoms or phenyl lower alkyl of 1 to 6 carbon atoms in the side chain;
- R.sub.2 is cyano, trifluoromethyl or lower alkanoyl of 1 to 6 carbon atoms;
- Y is lower alkyl of 1-6 carbon atoms.
- 2. A compound of claim 1 wherein q is 3.
- 3. A compound selected from a member having the formula ##STR13## wherein: m is 0 or an integer of 1 to 5,
- R is hydrogen or lower alkyl of 1 to 6 carbon atoms in the chain;
- R.sub.1 is lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 1 to 6 carbon atoms, lower cycloalkyl of 3 to 7 ring carbon atoms or phenyl lower alkyl of 1 to 6 carbon atoms in the side chain;
- R.sub.2 is cyano, trifluoromethyl or lower alkanoyl of 1 to 6 carbon atoms;
- Y is lower alkyl of 1-6 carbon atoms, when present and the acid addition addition salts thereof with organic or mineral acids.
- 4. A compound according to claim 3 selected from the group consisting of 1-(N-methyl-piperid-2-yl)-acetylamino-2-methoxy-5-trifluoromethyl-benzene and its hydrochloric acid addition salt.
- 5. A compound according to claim 3 which is 1-(N-ethyl-piperid-3-yl-carboxamido)-2-methoxy-5-trifluoromethyl-benzene.
- 6. A compound according to claim 3 which is 1-(.beta.-piperidino propionylamino) 2-methoxy 5-cyano benzene.
- 7. A composition active in inhibiting both gastric secretion and delay in gastric evacuation containing as the active ingredient an inhibitorily effective amount of at least one compound as claimed in claim 3 in association with a pharmaceutical carrier or diluent.
- 8. A composition as claimed in claim 7 in any of the forms suitable for oral, parenteral, rectal, perlingual or percutaneous administration.
- 9. A composition as claimed in claim 7 containing from 10 to 200 mg of active ingredient per dosage unit.
- 10. A method of inhibiting gastric hypersecretion and delay in gastric evacuation which comprises administering to warm-blooded animals suffering or disposed to suffer from said ailment an inhibitorily effective amount of a compound of claim 3.
- 11. The method of claim 10 wherein the amount ranges from 0.3 to 6 mg/kg body weight per day.
Priority Claims (1)
Number |
Date |
Country |
Kind |
6294/75 |
Feb 1975 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 656,553, filed Feb. 9, 1976 now U.S. Pat. No. 4,080,452.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
2912460 |
Ehrhart et al. |
Nov 1959 |
|
3989834 |
Maven et al. |
Nov 1976 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
656553 |
Feb 1976 |
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