Claims
- 1. A method for the treatment of cardiac arrhythmias comprising administering to a patient in need thereof, by an enteral or a parenteral route of administration, an antiarrhythmic amount of a compound of the formula: ##STR3## the optical isomers thereof, and the pharamaceutically acceptable salts thereof, wherein n is 2, 3, or 4, each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and amino.
- 2. The method of claim 1 wherein said compound is alpha-phenyl-1-(2-phenyl)-4-piperidine methanol.
- 3. The method of claim 1 wherein said compound is alpha-phenyl-1-(3-phenpropyl)-4-piperidine methanol.
- 4. The method of claim 1 wherein said compound is alpha-(4-methylphenyl)-1-(2-phenethyl)-4-piperidine methanol.
- 5. The method of claim 1 wherein said compound is alpha-(4-methoxyphenyl)-1-(2-phenethyl)-4-piperidine methanol.
- 6. The method of claim 1 wherein said compound is alpha-(3,5-dimethylphenyl)-1-(2-phenethyl)-4-piperidine methanol.
- 7. The method of claim 1, wherein said compound is alpha-(3-(tifluoromethyl)phenyl-1-(2-phenethyl)-4-piperidine methanol.
- 8. The method of claim 1, wherein said compound is alpha-(2,3-dimethoxy)-1-(2-phenethyl)-4-piperidine methanol.
- 9. The method of claim 1, wherein said compound is alpha-(3,4-dichlorophenyl)-1-(2-phenylethyl)-4-piperidine methanol.
Parent Case Info
This is a continuation of application Ser. No. 867,122, filed May 30, 1986 which is now abandoned, which is a continuation-in-part of application Ser. No. 751,419 filed July 2, 1985 which is now abandoned.
US Referenced Citations (10)
Foreign Referenced Citations (3)
Number |
Date |
Country |
840704 |
Jul 1960 |
GBX |
1314955 |
Apr 1973 |
GBX |
1469664 |
Jun 1977 |
GBX |
Non-Patent Literature Citations (4)
Entry |
Derwent Abstract 78-14451A (Abstract of French Pat. No. 2,350,341). |
Derwent Abstract 66-00470F (Abstract of British Pat. No. 843,070). |
R. E. Lyle, H. S. Troscianiec and G. H. Warner, J. Org. Chem. 24, 338-42 (1959). |
A. E. Petrarca, U Org Chem. 24, 1171-72 (1959). |
Continuations (1)
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Number |
Date |
Country |
Parent |
867122 |
May 1986 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
751419 |
Jul 1985 |
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