Claims
- 1. A compound of the formula ##STR3## the optical isomers thereof and the pharmaceutically acceptable salts thereof wherein n is 2, 3 or 4, each of R.sup.1,R.sup.2,R.sup.3,R.sup.4 independently is hydrogen, halogen, trifluormethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or amino.
- 2. A compound of claim 1 wherein n is 2.
- 3. A compound of claim 1 wherein n is 3.
- 4. A compound of claim 1 wherein R.sup.3 and R.sup.4 are hydrogen.
- 5. A compound of claim 4 wherein R.sup.1 and R.sup.2 are hydrogen.
- 6. A compound of claim 1 wherein R.sup.1 and R.sup.2 are methoxy and R.sup.3 and R.sup.4 are hydrogen.
- 7. A compound of claim 1 wherein R.sup.1 is methoxy and each of R.sup.2, R.sup.3 and R.sup.4 is hydrogen.
- 8. A compound of claim 1 wherein R.sup.1 and R.sup.2 are halogen and R.sup.3 and R.sup.4 is hydrogen.
- 9. A compound of claim 1 wherein R is methyl and R.sup.2, R.sup.3, R.sup.4 are hydrogen.
- 10. A compound according to claim 2 in which in R.sub.1 and R.sub.2 are methoxy, R.sub.3 is hydrogen and R.sub.4 is halogen.
- 11. An optical isomer of a compound according to claim 10.
- 12. A compound according to claim 1 in which said compound is alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol.
- 13. A compound according to claim 1 in which said compound is alpha-phenyl-1-(3-phenylpropyl)-4-piperidinemethanol.
- 14. A compound according to claim 1 in which said compound is alpha-(4-methylphenyl-1-(2-phenylethyl)-4-piperidinemethanol.
- 15. A compound according to claim 1 in which said compound is alpha-(4-methoxyphenyl)-1-(2-phenylethyl)-4-piperdinemethanol.
- 16. A compound according to claim 1 in which said compound is alpha-[4-(1-methylethyl)phenyl]-1-(2-phenylethyl)piperidinyl]-methanol.
- 17. A compound according to claim 1 in which said compound is alpha-(3,5-dimethylphenyl)-1-(2-phenylethyl)alpha-4-pieridinemethanol.
- 18. A compound according to claim 1 in which said compound is 1-(2-phenylethyl)-alpha-[3-trifluoromethyl)phenyl]-4-piperidinemethanol.
- 19. A compound according to claim 1 in which said compound is alpha-(2,3-dimethoxyphenyl)-1-(2-phenylethyl)-4-piperidinemethanol.
- 20. A compound according to claim 1 in which said compound is alpha-3,4-dichlorophenyl)-1-(2-phenylethyl)-4-piperidinemethanol.
CROSS REFERENCE TO RELATED APPLICATIONS
This is a divisional of application Ser. No. 428,256, filed Nov. 17, 1989, now U.S. Pat. No. 5,021,428, which is a divisional of Ser. No. 219,415, filed Jul. 15, 1988, now U.S. Pat. No. 4,912,117, issued Mar. 27, 1990, which is a divisional of Ser. No. 071,524, filed Jul. 7, 1987, now U.S. Pat. No. 4,783,471, issued Nov. 8, 1988, which is a continuation of Ser. No. 867,122, filed May 30, 1986, now abandoned, which was a continuation-in-part of Ser. No. 751,419, filed Jul. 2, 1985, now abandoned.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
750590 |
Nov 1970 |
BEX |
Divisions (3)
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Number |
Date |
Country |
Parent |
428256 |
Nov 1989 |
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Parent |
219415 |
Jul 1988 |
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Parent |
71524 |
Jul 1987 |
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Continuations (1)
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Number |
Date |
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Parent |
867122 |
May 1986 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
751419 |
Jul 1985 |
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