Claims
- 1. A compound of formula (I) which is ##STR3## wherein X is N;
- Y is CH;
- R.sup.1 is H, F, Cl, Br, C.sub.1 -C.sub.4 alkyl, phenyl, benzyl or OR.sup.2 where R.sup.2 is C.sub.1 -C.sub.4 alkyl, provided that when R.sup.1 is other than H, R.sup.1 is other than at the 7-position.
- 2. A compound of claim 1 having the formula: ##STR4## wherein X is N;
- Y is CH;
- R.sup.1 is H, F, Cl, Br, C.sub.1 -C.sub.4 alkyl; phenyl benzyl, or OR.sup.2 where R.sup.2 is C.sub.1 -C.sub.4 alkyl; provided that when R.sup.1 is other than H, R.sup.1 is other than at the 7-position.
- 3. A compound of claim 2 which is 4-indazol-1'-ylmethyl)phenylacetaldehyde.
- 4. A topical pharmaceutical composition consisting essentially of a carrier suitable for topical formulation and an efficacious amount of a compound having the formula: ##STR5## wherein X is N;
- Y is CH;
- R.sup.1 is H, F, Cl, Br, C.sub.1 -C.sub.4 alkyl, phenyl, provided that when R.sup.1 is other than H, R.sup.1 is other than at the 7-position.
- 5. The topical composition of claim 4 wherein the compound has the formula: ##STR6## wherein X is N
- Y is CH;
- R.sup.1 is H, F, Cl, Br, C.sub.1 -C.sub.4 alkyl, phenyl, benzyl or OR.sup.2 where R.sup.2 is C.sub.1 -C.sub.4 alkyl; provided that when R.sup.1 is other than H, R.sup.1 is other than at the 7-position.
- 6. The topical composition of claim 5 wherein the compound is 4-(indazol-1'-ymethyl) phenylacetaldehyde.
- 7. A method of treating a skin or mucoepithelial disease in a mammal comprising topically administering to the site of the disease on said mammal an efficaceous amount of a compound of the formula: ##STR7## wherein: X is N;
- Y is CH;
- R.sup.1 is H, H, F, Cl, Br, C1-C4 alkyl, phenyl, benzyl or OR.sup.2 where R.sup.2 is C.sub.1 -C.sub.4 alkyl; provided that when R.sup.1 is other than H, R.sup.1 is other than at the 7-position.
- 8. A method of treating a skin or mucoepithelial disease in a mammal comprising topically administering to the site of the disease on said mammal an efficaceous amount of a compound of the formula: ##STR8## wherein: X is CH;
- Y is N;
- R.sup.1 is H, F, Cl, Br, C.sub.1 -C.sub.4 alkyl, phenyl, benzyl or OR.sup.2 where R.sup.2 is C.sub.1 -C.sub.4 alkyl; provided that when R.sup.1 is other than H, R.sup.1 is other than at the 7-position.
- 9. The method of claim 8 wherein the compound is 4-(indazol-1'-ymethyl)phenylacetaldehyde.
RELATED APPLICATION
This application is a division of U.S. application Ser. No. 07/860,775, filed Mar. 27, 1992, now U.S. Pat. No. 5,217,983.
US Referenced Citations (5)
Foreign Referenced Citations (6)
Number |
Date |
Country |
178178A |
Apr 1986 |
EPX |
179619 |
Apr 1986 |
EPX |
199543 |
Oct 1986 |
EPX |
284686A |
Oct 1988 |
EPX |
48-44253 |
Feb 1973 |
JPX |
2081708 |
Feb 1982 |
GBX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
860775 |
Mar 1992 |
|